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Dissertations / Theses on the topic 'Umbilical Cord Blood Banking'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Paiva, Eny Dórea. "Experiência de enfermeiras que atuam na coleta de células-tronco de sangue de cordão umbilical." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/7/7132/tde-23012008-123846/.

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A coleta de sangue de cordão umbilical e placentário (SCUP) é uma atividade delegada ao enfermeiro, abrindo um novo campo de atuação para esse profissional que se configura em um novo processo de trabalho e na inserção de mais um procedimento no contexto da assistência obstétrica. O objetivo deste estudo foi compreender a vivência de enfermeiras no exercício da atividade de coleta de amostras de SCUP para armazenamento de células progenitoras hematopoiéticas. Trata-se de um estudo descritivo com abordagem metodológica qualitativa. Os referenciais teórico e metodológico adotados neste estudo fo

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2

Williams, Rosalind. "Blood in the archive : rethinking the public umbilical cord blood bank." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/12189/.

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The collection of umbilical cord blood (UCB), a source of clinically-useful stem cells, has become a highly strategised process known as ‘banking’, with 160 banks globally. State-funded public banks rely on unremunerated donations of UCB from women. STS scholarship has explored the broader ethical and economic tensions of such banks and the private enterprises offering banking for a family’s exclusive future use of their own donated tissue. Less focus has been given to public banks’ institutional practices and strategic concerns. I address this gap by adopting an archival lens popularised by J

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3

Majury, Anna L. "A study of natural killer cells in human umbilical cord blood." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22481.pdf.

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4

Ali, Hamad. "Neuronal potential of umbilical cord blood non-hematopoietic multipotent stem cells." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1277.

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The human central nervous system, one of the most complex organ systems anatomically and physiologically in the human body, is the body control center which manages and coordinates functions of all different organ systems. The lack of effective treatments and therapeutic intervention make injuries and disorders associated with the central nervous system one of the most dangerous and fatal health conditions worldwide. The adult nervous system has a limited capability of self-repair and regeneration following either a neurological disorder or injury. Despite being limited and ineffective in init

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5

Hirani, S. "The characterisation of human umbilical cord blood regulatory T cell subsets." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344048/.

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Umbilical cord blood (CB) is recognised to be a valuable alternative to bone marrow (BM) as a source of hematopoietic stem cells (HSC). The occurrence of Graft vs. Host Disease (GvHD) after CB transplantation has been reported to be less severe in comparison to BM transplants. In addition to the naive state of immune cells, the action of immuno-suppressive cells such as regulatory T cells (Treg) may contribute to the positive aspects observed in CB transplants. This study investigated the phenotypic and functional characteristics of CB Treg and their potential for expansion in culture. In addi

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6

Reed, Sarah Ann. "Isolation and characterization of equine umbilical cord blood derived stem cells." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0024724.

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7

Devine, Karen. "Unravelling the (DIS)CORD : Examining the social, legal and ethical implications of umbilical cord blood collection." Thesis, University of Kent, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508568.

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8

Basford, Christina Louise. "Production of stem cell populations from umbilical cord blood for regenerative medicine." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519640.

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9

Poniatowski, Adam F. "Effects of simulated microgravity on human umbilical cord blood hematopoietic stem cells." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0008840.

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10

Chalmers, Isobel Margaret Hood. "Cellular and cytokine profile of cord and adult blood mononuclear cells." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324413.

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Umbilical cord blood (CB) has been used as a source of haemopoietic stem cells in both related and unrelated bone marrow transplantation and in both settings there appears to be a reduced incidence of graft-versus-host disease (GVHD) when compared to bone marrow transplantation. The aim of this study was to perform a phenotypic and cellular analysis of both cord and adult mononuclear cells <I>in vitro</I> in order to identify any immunological characteristic that could account for the apparent reduced incidence of GVHD observed, <I>in vivo</I>. For this, the cell surface phenotype, allogeneic

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11

Andreasen, Debra S. "Stem Cells Derived from Umbilical Cord Blood (UCB)—A Promise for the Future." Fogler Library, University of Maine, 2011. http://www.library.umaine.edu/theses/pdf/AndreasenDS2011.pdf.

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12

Zwart, Isabel Brenda. "The potential of human umbilical cord blood-derived stem cells for neural repair." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498955.

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Stem cells are being investigated for the treatment of central nervous system (CNS) disorders, but the use of embryonic or foetal-derived cells is associated with practical and ethical problems. Studies suggest that human umbilical cord blood (hUGS) derived-stem cells may provide an alternative source of cells that can contribute to GNS repair. However, the extent to, and the means by which these cells may aid neural repair are unclear, with contradictory reports on the plasticity of these cells and their potential for neural differentiation. The aim of this project was to isolate and characte

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13

Rowe, Derrick. "Secreted Factors from Human Umbilical Cord Blood Cells Protect Oligodendrocytes from Ischemic Insult." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3323.

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Oligodendrocytes (OL)s are the dominant cell type in the white matter and are integral for synaptic transmission essential for proper neuronal communication between brain areas. Previous studies have shown that intravenous administration of the mononuclear fraction of human umbilical cord blood (HUCB) cells in rat models of stroke reduced white matter injury, gray matter injury and behavioral deficits. Yet the mechanisms used by HUCB cells remain unknown in ischemic injury. These studies will investigate both in vitro and in vivo approaches to elucidate this mechanism in OLs. When mature prima

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14

Darlington, Donna. "Implications of Human Umbilical Cord Blood Cells: An Immunotherapeutic Strategy for Alzheimer's Disease." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5208.

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ABSTRACT Alzheimer's disease (AD) is the most common progressive age related dementia and the fourth major cause of mortality in the elderly in the United States. AD is pathologically characterized by deposition of amyloid beta (Aβ) plaques in the brain parenchyma and neurofibrillary tangles (NFTs) within the neuronal soma. While pharmacological targets have been discovered, current strategies for the symptomatic or disease-modifying treatment of AD do not significantly slow or halt the underlying pathological progression of the disease. Consequently, more effective treatment is needed. One po

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15

To, Wilson King Lim. "A role of ATP in modulating vasomotion during hypoxia in umbilical cord blood vessels." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3313/.

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Previous studies have associated intracellular calcium ([Ca2+]i) oscillations in vascular smooth muscle cells (SMC) with vasomotion in multiple species. In normal and pre-eclamptic pregnancies, there is strong evidence to suggest that the intrauterine environment is hypoxic. The aim of this study was to investigate whether ATP and [Ca2+]i oscillations play a role in modulating vasomotion during hypoxia in human umbilical blood vessels. The results obtained from in vitro studies using firefly luciferase assay and quinacrine staining indicated that human umbilical artery and vein endothelial cel

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16

Weitzel, Richard Patrick. "microRNA-184 Regulation of NFAT1 in Umbilical Cord Blood CD4⁺ T-cells: Implications for Graft Versus Host Disease." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1277403551.

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17

Murthy, Vidya. "Telomerase activity in human umbilical cord cell populations containing hematopoietic stem cells." Link to electronic thesis, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-0430102-105910.

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18

Hassall, Oliver William. "The feasibility,safety and efficacy of umbilical cord blood transfusion for severe anaemia in children." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526880.

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19

Pedroza-Pacheco, I. "Effect of umbilical cord blood regulatory T cells on natural killer cell differentiation and function." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1429973/.

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Graft versus Host Disease (GvHD) remains one of the main complications after haematopoietic stem cell transplantation (HSCT). Due to their ability to suppress effector cells, CD4+CD25highFoxp3high regulatory T (Treg) cells have been proposed as a cellular therapy to prevent GvHD. However it has been shown that Treg cells can inhibit natural killer (NK) cell functions. NK cells are key effectors of the Graft versus Leukaemia (GvL) effect post-transplant; therefore, it is plausible that a Treg cell therapy may impact on NK cell function and differentiation from haematopoietic stem cells (HSC). T

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20

Srivastava, Saket. "The generation and characterisation of alloantigen reactive regulatory T cell populations from umbilical cord blood." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10026041/.

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The use of polyclonal CD4+ CD25+ FoxP3+ regulatory T cells (Treg) have been successful in the management of acute graft versus host disease (aGvHD), a complication associated with allogeneic haematopoietic stem cell transplantation. However, polyclonal Tregs can cause broad immunosuppression of desired responses. To avoid this, the use of alloantigen reactive Tregs has been suggested, with pre-clinical data indicating that allospecific Tregs are more efficient than polyclonal Tregs in suppressing allospecific responses. This thesis demonstrates the generation and characterisation of alloantige

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21

AZARIO, ISABELLA MARIA REBECCA. "Neonatal transplantation of umbilical cord blood as a new therapeutic option for Mucopolysaccharidosis type I." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199019.

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Lo scopo di questo progetto è stato lo sviluppo preclinico di una nuova terapia per la Mucopolisaccaridosi di tipo I (MPS-I): il trapianto di cellule staminali da sangue del cordone ombelicale, eseguito in epoca neonatale. L’MPS-I è una rara malattia lisosomiale dovuta a mutazioni nel gene IDUA, che codifica per l’enzima lisosomiale α-L-iduronidasi (IDUA). L’assenza di attività iduronidasica provoca l’accumulo di glicosaminoglicani nei tessuti, causando una disfunzione multi-organo progressiva e, in particolare, gravi anomalie scheletriche. La terapia d’elezione per la MPS-I è il trapianto di

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22

Kwok, Ka-yin, and 郭家賢. "Ex vivo expansion, microRNA expression and immortalization of CD34⁺ cells derived from human umbilical cord blood." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43572145.

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23

Luevano, Salinas M. E. "Generation of natural killer cells from umbilical cord blood stem cells, characterisation and application for immunotherapy." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1411341/.

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Adoptive (Natural killer) NK cell therapy relies on the use of a large amount of NK cells that are cytotoxic, and yet not exhausted. For this purpose, NK cells can be isolated from cord blood, peripheral blood or generated in vitro from haematopoietic stem cells (HSC). In vitro generation of high numbers of activated NK cells using HSC would facilitate multiple infusions and treatment of patients with large tumour burden, allowing to by-pass the limitations of NK cell numbers and activation state of blood-derived NK cells. However, comprehensive studies about the use of fresh or cryopreserved

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24

Kanji, Suman. "Nanofiber-expanded human umbilical cord blood-derived CD34+ stem cell-mediated wound healing and underlying mechanisms." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376957233.

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25

Kwok, Ka-yin. "Ex vivo expansion, microRNA expression and immortalization of CD34⁺ cells derived from human umbilical cord blood." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43572145.

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26

Boms, Jana [Verfasser]. "The effects of maternal childhood maltreatment on the cell composition in blood counts of maternal and umbilical cord blood / Jana Boms." Ulm : Universität Ulm, 2020. http://d-nb.info/1205807535/34.

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27

Miles, Elizabeth Ann. "Neonatal lymphocyte responses in relation to subsequent allergic disease in infants born to atopic parents." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296247.

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28

Dusing, Stacey Chapman Thorpe Deborah E. "Gross motor and gait abilities of children with Hurler syndrome, pre and post umbilical cord blood transplant." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,266.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree Doctor of Philosophy in the School of Medicine (Curriculum in Human Movement Science)." Discipline: Human Movement Science; Department/School: Medicine.

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29

Bizzetto, Renata. "Transplante de sangue de cordão umbilical aparentado e não aparentado para pacientes com síndromes de insuficiência medular hereditárias, excluindo anemia Fanconi." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313342.

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Orientador: Carmino Antonio de Souza<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-17T18:40:20Z (GMT). No. of bitstreams: 1 Bizzetto_Renata_M.pdf: 5388324 bytes, checksum: 8344246752d17626b3442925d28a5b44 (MD5) Previous issue date: 2010<br>Resumo: O transplante com células tronco hematopeticas é a única opção curativa para os pacientes com síndromes de insuficiência medular hereditárias (SIMH). O sangue de cordão umbilical é uma fonte alternativa de células tronco hematopoéticas para o transplante alogênico

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30

Godoy, Roberta Ferro de [UNESP]. "Imunofenotipagem de subpopulações de linfócitos-T no sangue do cordão umbilical de eqüinos." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/101134.

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Made available in DSpace on 2014-06-11T19:31:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-06-13Bitstream added on 2014-06-13T20:41:25Z : No. of bitstreams: 1 godoy_rf_dr_jabo.pdf: 1788688 bytes, checksum: 4ccc9b3b87b86597a8dc9255e154fe46 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Apesar da importância do sangue do cordão umbilical (SCU) como fonte de células tronco e do advento da imunofenotipagem de linfócitos, não existem estudos sobre a imunofenotipagem de linfócitos do sangu

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31

Newman, Mary B. "Human umbilical cord blood cells migration to stroke cns tissue extracts and the potential cytokines and chemokines involved." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001206.

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32

Gertz, Jacqueline Michelle. "Cellular And Molecular Events Regulating Factor V Endocytosis By Megakaryocytes." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/401.

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Platelet- and plasma-derived factor Va are absolutely essential for thrombin generation catalyzed by the prothrombinase complex, a 1:1 stoichiometric complex of the serine protease factor Xa and the nonenzymatic cofactor, factor Va, assembled on an appropriate membrane surface in the presence of calcium ions. Two whole blood pools of the procofactor, factor V, exist: approximately 75% circulates in the plasma as a single chain inactive molecule, while the other 25% resides in platelet Î±-granules in a partially proteolytically-activated state. Our laboratory demonstrated that the platelet-deri

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33

Yan, Ping. "Changes in fetal egg and blood pressure in normally grown and chronic placental embolization fetal sheep during graded cord occlusions." Thesis, The University of Sydney, 2003. https://hdl.handle.net/2123/27957.

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The fetal electrocardiogram (FECG) has been considered a potentially useful tool for fetal surveillance during birth as technical improvements in signal acquisition and processing have been achieved. The aim of the thesis is to determine the ability of the changes in fetal ECG morphological characteristics and time intervals (FI-IR, PR interval, T/QRS, and R height) to predict fetal hypoxemia /acidemia and relationships between these parameters of FECG and fetal blood pressure.

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34

Miller, Danielle. "Intestinal absorption of colostral leukocytes, peripheral blood mononuclear cells, and porcine umbilical cord matrix stem cells by neonatal pigs." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/916.

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35

Alhamud, Alkathafi Ali. "The use of a neural network to recognize placental insufficiency from blood flow velocity waveforms in the umbilical cord." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/3220.

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Includes bibliographical references (leaves 120-128).<br>Present-day obstetric decision-making is based on measuring the umbilical arterial blood flow velocity waveforms from one site of the cord. There is an ongoing debate on the predictive value of Doppler measurements in the evaluation of the foetal condition. The aim of this thesis is to investigate the use ofa neural network to recognise blood flow waveform shape patterns associated with placental insufficiency. Eleven backpropagation neural networks have been developed and trained based on the waveforms that are generated from the foetal

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36

Barreiros, Rodrigo Crespo. "Frutose, sorbitol e glicose em sangue de mãe, cordão umbilical e recém-nascido de termo com 48 horas de vida /." Botucatu : [s.n.], 2006. http://hdl.handle.net/11449/104683.

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Orientador: Cleide Enoir Petean Trindade<br>Banca: Clovis Duarte Costa<br>Banca: Maria Fernanda Branco de Almeida<br>Banca: Francisco Eulógio Martinez<br>Banca: Lígia Maria Suppo de Souza Rugolo<br>Resumo: A frutose é um açúcar derivado da glicose pela via do sorbitol presente em placentas de animais ungulados. Em humanos existem poucos relatos sobre a produção de frutose e de polióis pela unidade feto-placentária. Determinar a relação entre os níveis sangüíneos de frutose, sorbitol e glicose em mães, em veia de cordão umbilical e em recém-nascidos de termo em aleitamento materno exclusivo. As

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37

Godoy, Roberta Ferro de. "Imunofenotipagem de subpopulações de linfócitos-T no sangue do cordão umbilical de eqüinos /." Jaboticabal : [s.n.], 2006. http://hdl.handle.net/11449/101134.

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Orientador: Aureo Evangelista Santana<br>Banca: Ana Paula Massae Nakage Canesin<br>Banca: Maria Angélica Dias<br>Banca: Márcia Rita Fernandes Canola<br>Banca: Julio Carlos Canola<br>Resumo: Apesar da importância do sangue do cordão umbilical (SCU) como fonte de células tronco e do advento da imunofenotipagem de linfócitos, não existem estudos sobre a imunofenotipagem de linfócitos do sangue do cordão umbilical eqüino. Este estudo visou determinar os valores eritroleucométricos e quantificar as subpopulações de linfócitos-T no SCU e no sangue obtido por venipunção da jugular de eqüinos neonatos

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38

Erickson-Owens, Debra A. "Milking the umbilical cord at term cesarean section : effect on hemoglobin levels in the first 48 hours of life /." View online ; access limited to URI, 2009. http://0-digitalcommons.uri.edu.helin.uri.edu/dissertations/AAI3367990.

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39

Rodrigues, Gustavo Coelho. "Caracterização ultraestrutural de células do sangue de cordão umbilical de bovinos azebuados." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-29042004-180938/.

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Estudos envolvendo a utilização do sangue de cordão umbilical foram intensificados na última década, devido ao grande potencial que estas possuem nas pesquisas de transplantes e ontogenia celular. A investigação dos métodos para a purificação e caracterização dessas células em diferentes animais pode aumentar a utilização destes como modelos experimentais para uma variedade de propostas científicas e terapêuticas. Para desenvolver a caracterização das células de sangue de cordão umbilical foram utilizadas 20 amostras oriundas de fetos de com idades compatíveis ao segundo e terceiro terço de g

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Passos, Paula Renata Machado. "Associação entre os níveis citoplasmáticos da enzima aldeído desidrogenase (ALDH) e a capacidade proliferativa \"in vitro\" das células progenitoras hematopoéticas de sangue de cordão umbilical e placentário." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17155/tde-13092018-160308/.

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A utilização das células progenitoras hematopoéticas (CPH) obtidas do sangue de cordão umbilical e placentário (SCUP) apresenta vários benefícios para o transplante de CPH em comparação às células provenientes de outras fontes. Dentre eles, a maior disponibilidade e a maior imaturidade imunológica das CPH, o que permite certa flexibilidade nos critérios de compatibilidade entre doador e receptor e uma menor taxa de reação do enxerto-versus-hospedeiro. A legislação brasileira e órgãos internacionais exigem a realização de vários testes para garantir a qualidade do produto hemoterápico contendo

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41

Barreiros, Rodrigo Crespo [UNESP]. "Frutose, sorbitol e glicose em sangue de mãe, cordão umbilical e recém-nascido de termo com 48 horas de vida." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/104683.

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Made available in DSpace on 2014-06-11T19:33:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-11-24Bitstream added on 2014-06-13T21:06:10Z : No. of bitstreams: 1 barreiros_rc_dr_botfm.pdf: 473320 bytes, checksum: d48850cb60fbcfdb82cad35020b3bab2 (MD5)<br>A frutose é um açúcar derivado da glicose pela via do sorbitol presente em placentas de animais ungulados. Em humanos existem poucos relatos sobre a produção de frutose e de polióis pela unidade feto-placentária. Determinar a relação entre os níveis sangüíneos de frutose, sorbitol e glicose em mães, em veia de cordão umbilical e em

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42

Reich, Doreen Melanie. "Investigation of the Therapeutic Potential of (Stem) Cell Containing Human Umbilical Cord Blood Fractions for Repair of Ischemic Neuronal Damage." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-63584.

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In Form einer Zusammenfassung aus zwei Publikationen und bisher unveröffentlichtem Material stellt die vorliegende Arbeit die Frage, welche der Zellfraktionen (HUCB-MNC, CD45+/CD34+ und CD45+/CD133+) innerhalb des heterogenen HUCB die am effektivsten wirksame in Hinblick auf die Neuroprotektion nach einem experimentellen Schlaganfall ist und welche Mechanismen dabei zum Tragen kommen. Für die Untersuchung der molekularen Mechanismen des Zusammenwirkens zwischen den genannten HUCB Fraktionen und neuronalen Zellen bzw. Gewebe, kamen ein selbst etabliertes Zellkulturmodel neuronaler Hypoxie bzw.

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43

Bennstein, Sabrina Bianca [Verfasser], Markus [Gutachter] Uhrberg, and Philipp A. [Gutachter] Lang. "Characterization of human innate lymphoid cells (ILCs) in umbilical cord blood / Sabrina Bianca Bennstein ; Gutachter: Markus Uhrberg, Philipp A. Lang." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1234712113/34.

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44

Sethia, Pavan P. "Development and Commercialization of Menstrual Blood Stem Cells Banking." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1303759438.

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45

Pacitti, Andrew P. "Isolation of Mesenchymal Stem Cells Derived from Adult Bone Marrow and Umbilical Cord Blood and Their Potential to Differentiate into Osteoblasts." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/728.

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The demand for treatment strategies of musculoskeletal tissues is continuously growing, especially considering the increasing number of elderly people with degenerative diseases of the skeletal system. Despite major strides in the field of bone regenerative medicine during the years, current therapies, such as bone grafts, still have several limitations. Multipotent stem cells, such as mesenchymal stem cells (MSCs) are promising candidates for tissue repair because of their differentiation potential and their capacity to undergo extensive replication. However, isolating a homogeneous populatio

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Hovey, Owen. "Characterization of Proteins Released by Osteoblasts That Promote Expansion of Hematopoietic Progenitors." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38012.

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Umbilical cord blood (UCB) is a source of hematopoietic stem and progenitor cells (HSPC) used for allogeneic transplantation. Ex vivo expansion of HSPC can improve the slow platelet and neutrophil engraftment associated with UCB transplants. HSPCs reside in niches, some of which are near the endosteal bone surface, where they can associate with immature osteoblasts. Interestingly, osteoblasts can enhance the growth of HSPC in culture and their platelet engraftment activity. Using a proteomics approach, I identified 47 differentially expressed proteins between mesenchymal stem cells and immatur

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Iftimia-Mander, Andreea D. "Mesenchymal stem cell extraction from human umbilical cord tissue : processing to understand and minimise variability in cell yield." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/13643.

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Human tissue banks are a potential source of cellular material for the emerging cellbased therapy industry; umbilical cord tissue (UCT) private banking is increasing in such facilities as a source of mesenchymal stem cells for future therapeutic use. However, early handling of UCT is relatively uncontrolled due to the clinical demands of the birth environment and subsequent transport logistics. It is therefore necessary to develop extraction methods that are robust to real world operating conditions,rather than idealised operation. This will be critical for all processes using primary tissue o

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Ozorio, Juliana Jarra. "Isolamento, quantificação e caracterização morfológica de células mesenquimais de sangue do cordão umbilical canino." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-08092008-132845/.

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Esse projeto tem como objetivo estabelecer técnicas de cultivo, isolamento, expansão e quantificação de células mesenquimais e hematopoéticas de sangue de cordão umbilical (SCU) de cães de raças variadas para aplicação em terapias celulares. Atualmente, vários tipos de células-tronco têm sido estudados devido a sua capacidade de diferenciação em diversos tecidos (HERZOG et al., 2003). O isolamento, quantificação e expansão dessas células permitem que a terapia celular seja utilizada na tentativa de tratamento em patologias (BARKER et al., 2003). Entre as fontes de células-tronco adultas (medul

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Samarkanova, Dinara. "Umbilical Cord Blood Platelet Rich Plasma derivatives for therapeutic applications and development of clinical trials for treatment of skin and ocular ulcers." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670817.

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Entre els avantatges en l'ús de la sang de cordó (CB) com a font de plaquetes i de l'plasma per a la medicina regenerativa es destaquen la disponibilitat, l'ús universal i el material biològic viralment segur, ric en factors regeneratius. Els derivats de l'plasma ric en plaquetes de cordó (CB-PRP) s'han investigat com a possibles agents terapèutics per al tractament de diverses afeccions, entre elles les malalties de la superfície ocular i les úlceres de la pell. L'objectiu d'aquesta tesi és validar un disseny de bioprocés per a la producció de concentrats de plaquetes derivats de cordó (CB

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Chang, Ya-Yuan, and 張雅媛. "Analyzing cross-border R&D network in emerging economy: The umbilical cord blood banking industry." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/26880168732595875370.

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