Log in

Relevant bibliographies by topics / Unc-5 / Journal articles

To see the other types of publications on this topic, follow the link: Unc-5.

Journal articles on the topic 'Unc-5'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Unc-5.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Lee, Jeeyong, Weiquan Li, and Kun-Liang Guan. "SRC-1 Mediates UNC-5 Signaling in Caenorhabditis elegans." Molecular and Cellular Biology 25, no. 15 (2005): 6485–95. http://dx.doi.org/10.1128/mcb.25.15.6485-6495.2005.

Full text

Abstract:

ABSTRACT The secreted molecule unc-6/netrin is important for guiding axon projections and cell migrations. unc-5 and unc-40/DCC are identified as receptors for unc-6/netrin. The downstream factors of unc-6 receptors are beginning to be elucidated, and some key factors have been identified in various organisms. Here, we showed that SRC-1 interacts with the cytosolic domain of UNC-5 through its SH2 domain. This interaction also requires the intact kinase activity of SRC-1. Downregulation of src-1 by RNA interference decreases the biological processes initiated by the UNC-5 protein and decreases

APA, Harvard, Vancouver, ISO, and other styles

2

MacNeil, Lesley T., W. Rod Hardy, Tony Pawson, Jeffrey L. Wrana, and Joseph G. Culotti. "UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways." Nature Neuroscience 12, no. 2 (2009): 150–55. http://dx.doi.org/10.1038/nn.2256.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

MacNeil, L., J. L. Wrana, and J. G. Culotti. "[ST6]: UNC‐129 acts in the UNC‐5/UNC‐6 pathway to regulate axon guidance." International Journal of Developmental Neuroscience 24, no. 8 (2006): 490–91. http://dx.doi.org/10.1016/j.ijdevneu.2006.09.051.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Merz, David C., Hong Zheng, Marie T. Killeen, Aldis Krizus, and Joseph G. Culotti. "Multiple Signaling Mechanisms of the UNC-6/netrin Receptors UNC-5 and UNC-40/DCC in Vivo." Genetics 158, no. 3 (2001): 1071–80. http://dx.doi.org/10.1093/genetics/158.3.1071.

Full text

Abstract:

Abstract Cell and growth cone migrations along the dorsoventral axis of Caenorhabditis elegans are mediated by the UNC-5 and UNC-40 receptor subtypes for the secreted UNC-6 guidance cue. To characterize UNC-6 receptor function in vivo, we have examined genetic interactions between unc-5 and unc-40 in the migrations of the hermaphrodite distal tip cells. We report that cell migration defects as severe as those associated with a null mutation in unc-6 are produced only by null mutations in both unc-5 and unc-40, indicating that either receptor retains some partial function in the absence of the

APA, Harvard, Vancouver, ISO, and other styles

5

Miller, Rachel K., Hiroshi Qadota, Thomas J. Stark, et al. "CSN-5, a Component of the COP9 Signalosome Complex, Regulates the Levels of UNC-96 and UNC-98, Two Components of M-lines in Caenorhabditis elegans Muscle." Molecular Biology of the Cell 20, no. 15 (2009): 3608–16. http://dx.doi.org/10.1091/mbc.e09-03-0208.

Full text

Abstract:

In Caenorhabditis elegans two M-line proteins, UNC-98 and UNC-96, are involved in myofibril assembly and/or maintenance, especially myosin thick filaments. We found that CSN-5, a component of the COP9 signalosome complex, binds to UNC-98 and -96 using the yeast two-hybrid method. These interactions were confirmed by biochemical methods. The CSN-5 protein contains a Mov34 domain. Although one other COP9 signalosome component, CSN-6, also has a Mov34 domain, CSN-6 did not interact with UNC-98 or -96. Anti-CSN-5 antibody colocalized with paramyosin at A-bands in wild type and colocalized with abn

APA, Harvard, Vancouver, ISO, and other styles

6

Su, M., D. C. Merz, M. T. Killeen, et al. "Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans." Development 127, no. 3 (2000): 585–94. http://dx.doi.org/10.1242/dev.127.3.585.

Full text

Abstract:

Cell migrations play a critical role in animal development and organogenesis. Here, we describe a mechanism by which the migration behaviour of a particular cell type is regulated temporally and coordinated with over-all development of the organism. The hermaphrodite distal tip cells (DTCs) of Caenorhabditis elegans migrate along the body wall in three sequential phases distinguished by the orientation of their movements, which alternate between the anteroposterior and dorsoventral axes. The ventral-to-dorsal second migration phase requires the UNC-6 netrin guidance cue and its receptors UNC-5

APA, Harvard, Vancouver, ISO, and other styles

7

Norris, A. D., L. Sundararajan, D. E. Morgan, Z. J. Roberts, and E. A. Lundquist. "The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP." Development 141, no. 22 (2014): 4395–405. http://dx.doi.org/10.1242/dev.110437.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Poon, Vivian Y., Matthew P. Klassen, and Kang Shen. "UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites." Nature 455, no. 7213 (2008): 669–73. http://dx.doi.org/10.1038/nature07291.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Chen, Shih-Yu, Chun-Ta Ho, Wei-Wen Liu, et al. "Regulation of axon repulsion by MAX-1 SUMOylation and AP-3." Proceedings of the National Academy of Sciences 115, no. 35 (2018): E8236—E8245. http://dx.doi.org/10.1073/pnas.1804373115.

Full text

Abstract:

During neural development, growing axons express specific surface receptors in response to various environmental guidance cues. These axon guidance receptors are regulated through intracellular trafficking and degradation to enable navigating axons to reach their targets. In Caenorhabditis elegans, the UNC-5 receptor is necessary for dorsal migration of developing motor axons. We previously found that MAX-1 is required for UNC-5–mediated axon repulsion, but its mechanism of action remained unclear. Here, we demonstrate that UNC-5–mediated axon repulsion in C. elegans motor axons requires both

APA, Harvard, Vancouver, ISO, and other styles

10

Broday, Limor, Irina Kolotuev, Christine Didier, Anindita Bhoumik, Benjamin Podbilewicz, and Ze'ev Ronai. "The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans." Journal of Cell Biology 165, no. 6 (2004): 857–67. http://dx.doi.org/10.1083/jcb.200401133.

Full text

Abstract:

Here, we describe a new muscle LIM domain protein, UNC-95, and identify it as a novel target for the RING finger protein RNF-5 in the Caenorhabditis elegans body wall muscle. unc-95(su33) animals have disorganized muscle actin and myosin-containing filaments as a result of a failure to assemble normal muscle adhesion structures. UNC-95 is active downstream of PAT-3/β-integrin in the assembly pathways of the muscle dense body and M-line attachments, and upstream of DEB-1/vinculin in the dense body assembly pathway. The translational UNC-95::GFP fusion construct is expressed in dense bodies, M-l

APA, Harvard, Vancouver, ISO, and other styles

11

Kim, S., X. C. Ren, E. Fox, and W. G. Wadsworth. "SDQR migrations in Caenorhabditis elegans are controlled by multiple guidance cues and changing responses to netrin UNC-6." Development 126, no. 17 (1999): 3881–90. http://dx.doi.org/10.1242/dev.126.17.3881.

Full text

Abstract:

The netrin guidance cue, UNC-6, and the netrin receptors, UNC-5 and UNC-40, guide SDQR cell and axon migrations in C. elegans. In wild-type larvae, SDQR migrations are away from ventral UNC-6-expressing cells, suggesting that UNC-6 repels SDQR. In unc-6 null larvae, SDQR migrations are towards the ventral midline, indicating a response to other guidance cues that directs the migrations ventrally. Although ectopic UNC-6 expression dorsal to the SDQR cell body would be predicted to cause ventral SDQR migrations in unc-6 null larvae, in fact, more migrations are directed dorsally, suggesting that

APA, Harvard, Vancouver, ISO, and other styles

12

Shifman, M. I., and M. E. Selzer. "Expression of the Netrin Receptor UNC-5 in Lamprey Brain: Modulation by Spinal Cord Transection." Neurorehabilitation and Neural Repair 14, no. 1 (2000): 49–58. http://dx.doi.org/10.1177/154596830001400106.

Full text

Abstract:

The sea lamprey recovers from spinal cord transection by a process that involves directionally specific regeneration of axons. The mechanisms underlying this speci ficity are not known, but they may involve molecular cues similar to those that guide the growth of spinal cord axons during development, such as netrins and semaphorins. To test the role of guidance cues in regeneration, we cloned netrin and its receptor UNC-5 from lamprey central nervous system (CNS) and studied their expression after spinal cord transection. In situ hybridization showed that (1) mRNA for netrin is ex pressed in t

APA, Harvard, Vancouver, ISO, and other styles

13

Ogura, Ken-ichi, Taro Asakura, and Yoshio Goshima. "Localization mechanisms of the axon guidance molecule UNC-6/Netrin and its receptors, UNC-5 and UNC-40, in Caenorhabditis elegans." Development, Growth & Differentiation 54, no. 3 (2012): 390–97. http://dx.doi.org/10.1111/j.1440-169x.2012.01349.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Norris, A. D., and E. A. Lundquist. "UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans." Development 138, no. 20 (2011): 4433–42. http://dx.doi.org/10.1242/dev.068841.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Carr, B., and P. Anderson. "Imprecise excision of the Caenorhabditis elegans transposon Tc1 creates functional 5' splice sites." Molecular and Cellular Biology 14, no. 5 (1994): 3426–33. http://dx.doi.org/10.1128/mcb.14.5.3426.

Full text

Abstract:

Imprecise excision of the Caenorhabditis elegans transposon Tc1 from a specific site of insertion within the unc-54 myosin heavy chain gene generates either wild-type or partial phenotypic revertants. Wild-type revertants and one class of partial revertants contain insertions of four nucleotides in the unc-54 third exon (Tc1 "footprints"). Such revertants express large amounts of functional unc-54 myosin despite having what would appear to be frameshifting insertions in the unc-54 third exon. We demonstrate that these Tc1 footprints act as efficient 5' splice sites for removal of the unc-54 th

APA, Harvard, Vancouver, ISO, and other styles

16

Carr, B., and P. Anderson. "Imprecise excision of the Caenorhabditis elegans transposon Tc1 creates functional 5' splice sites." Molecular and Cellular Biology 14, no. 5 (1994): 3426–33. http://dx.doi.org/10.1128/mcb.14.5.3426-3433.1994.

Full text

Abstract:

Imprecise excision of the Caenorhabditis elegans transposon Tc1 from a specific site of insertion within the unc-54 myosin heavy chain gene generates either wild-type or partial phenotypic revertants. Wild-type revertants and one class of partial revertants contain insertions of four nucleotides in the unc-54 third exon (Tc1 "footprints"). Such revertants express large amounts of functional unc-54 myosin despite having what would appear to be frameshifting insertions in the unc-54 third exon. We demonstrate that these Tc1 footprints act as efficient 5' splice sites for removal of the unc-54 th

APA, Harvard, Vancouver, ISO, and other styles

17

Stringham, Eve, Nathalie Pujol, Joel Vandekerckhove, and Thierry Bogaert. "unc-53 controls longitudinal migration in C. elegans." Development 129, no. 14 (2002): 3367–79. http://dx.doi.org/10.1242/dev.129.14.3367.

Full text

Abstract:

Cell migration and outgrowth are thought to be based on analogous mechanisms that require repeated cycles of process extension, reading and integration of multiple directional signals, followed by stabilisation in a preferred direction, and renewed extension. We have characterised a C. elegans gene, unc-53, that appears to act cell autonomously in the migration and outgrowth of muscles, axons and excretory canals. Abrogation of unc-53 function disrupts anteroposterior outgrowth in those cells that normally express the gene. Conversely, overexpression of unc-53 in bodywall muscles leads to exag

APA, Harvard, Vancouver, ISO, and other styles

18

Eide, David, and Philip Anderson. "THE GENE STRUCTURES OF SPONTANEOUS MUTATIONS AFFECTING A CAENORHABDITIS ELEGANS MYOSIN HEAVY CHAIN GENE." Genetics 109, no. 1 (1985): 67–79. http://dx.doi.org/10.1093/genetics/109.1.67.

Full text

Abstract:

ABSTRACT We have isolated spontaneous mutations affecting the unc-54 major myosin heavy chain gene of Caenorhabditis elegans (variety Bristol). Spontaneous unc-54 mutants occur in C. elegans populations at a frequency of approximately 3 × 10-7. We have studied the gene structure of 65 independent unc-54 mutations using filter-transfer hybridization techniques. Most unc-54 mutations (50 of 65) exhibit no abnormalities detected with these techniques; these mutations are small lesions affecting less than 100 base pairs. Approximately 17% of the mutations (11 of 65) are simple deletions, ranging i

APA, Harvard, Vancouver, ISO, and other styles

19

Hedgecock, Edward M., Joseph G. Culotti, and David H. Hall. "The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans." Neuron 4, no. 1 (1990): 61–85. http://dx.doi.org/10.1016/0896-6273(90)90444-k.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Esmaeili, Behrooz, Jennifer M. Ross, Cara Neades, David M. Miller, and Julie Ahringer. "The C. elegans even-skipped homologue, vab-7, specifies DB motoneurone identity and axon trajectory." Development 129, no. 4 (2002): 853–62. http://dx.doi.org/10.1242/dev.129.4.853.

Full text

Abstract:

Locomotory activity is defined by the specification of motoneurone subtypes. In the nematode, C. elegans, DA and DB motoneurones innervate dorsal muscles and function to induce movement in the backwards or forwards direction, respectively. These two neurone classes express separate sets of genes and extend axons with oppositely directed trajectories; anterior (DA) versus posterior (DB). The DA-specific homeoprotein UNC-4 interacts with UNC-37/Groucho to repress the DB gene, acr-5 (nicotinic acetylcholine receptor subunit). We show that the C. elegans even-skipped-like homoedomain protein, VAB-

APA, Harvard, Vancouver, ISO, and other styles

21

Anderson, Richard B., and Christine E. Holt. "Expression of UNC-5 in the developing Xenopus visual system." Mechanisms of Development 118, no. 1-2 (2002): 157–60. http://dx.doi.org/10.1016/s0925-4773(02)00215-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Howell, A. M., S. G. Gilmour, R. A. Mancebo, and A. M. Rose. "Genetic analysis of a large autosomal region in Caenorhabditis elegans by the use of a free duplication." Genetical Research 49, no. 3 (1987): 207–13. http://dx.doi.org/10.1017/s0016672300027099.

Full text

Abstract:

SummaryIn this paper we describe the use of a free duplication, sDp2 (I;f), for the recovery, maintenance, and analysis of mutations defining essential genes in the left third of Linkage Group I of Caenorhabditis elegans. The lethals were induced in a strain of genotype (sDp2) + /dpy-5 + unc-13/ dpy-5 unc-15 +, using either 12 mM ethylmethane sulphonate or 1500 r of gamma radiation. Lethal mutations linked to the dpy-5 unc-13 chromosome were recognized by the absence of Dpy-5 Unc-13 individuals amongst the self progeny and were maintained by isolating Unc-13 hermaphrodites. These strains – whi

APA, Harvard, Vancouver, ISO, and other styles

23

Ogura, K. i. "The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans." Development 133, no. 17 (2006): 3441–50. http://dx.doi.org/10.1242/dev.02503.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Levin, JZ, and HR Horvitz. "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction." Journal of Cell Biology 117, no. 1 (1992): 143–55. http://dx.doi.org/10.1083/jcb.117.1.143.

Full text

Abstract:

unc-93 is one of a set of five interacting genes involved in the regulation or coordination of muscle contraction in Caenorhabditis elegans. Rare altered-function alleles of unc-93 result in sluggish movement and a characteristic "rubber band" uncoordinated phenotype. By contrast, null alleles cause no visibly abnormal phenotype, presumably as a consequence of the functional redundancy of unc-93. To understand better the role of unc-93 in regulating muscle contraction, we have cloned and molecularly characterized this gene. We isolated transposon-insertion alleles and used them to identify the

APA, Harvard, Vancouver, ISO, and other styles

25

Yin, Jianhua, Yaling Huang, Pengfei Guo, et al. "GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans." Journal of Cell Biology 216, no. 6 (2017): 1775–94. http://dx.doi.org/10.1083/jcb.201610001.

Full text

Abstract:

Apoptotic cells generated by programmed cell death are engulfed by phagocytes and enclosed within plasma membrane–derived phagosomes. Maturation of phagosomes involves a series of membrane-remodeling events that are governed by the sequential actions of Rab GTPases and lead to formation of phagolysosomes, where cell corpses are degraded. Here we identified gop-1 as a novel regulator of apoptotic cell clearance in Caenorhabditis elegans. Loss of gop-1 affects phagosome maturation through the RAB-5–positive stage, causing defects in phagosome acidification and phagolysosome formation, phenotypes

APA, Harvard, Vancouver, ISO, and other styles

26

Honigberg, L., and C. Kenyon. "Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans." Development 127, no. 21 (2000): 4655–68. http://dx.doi.org/10.1242/dev.127.21.4655.

Full text

Abstract:

The bilateral C. elegans neuroblasts QL and QR are born in the same anterior/posterior (A/P) position, but polarize and migrate left/right asymmetrically: QL migrates toward the posterior and QR migrates toward the anterior. After their migrations, QL but not QR switches on the Hox gene mab-5. We find that the UNC-40/netrin receptor and a novel transmembrane protein DPY-19 are required to orient these cells correctly. In unc-40 or dpy-19 mutants, the Q cells polarize randomly; in fact, an individual Q cell polarizes in multiple directions over time. In addition, either cell can express MAB-5.

APA, Harvard, Vancouver, ISO, and other styles

27

Leonardo, E. David, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu, Susan L. Ackerman, and Marc Tessier-Lavigne. "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors." Nature 386, no. 6627 (1997): 833–38. http://dx.doi.org/10.1038/386833a0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Killeen, Marie, Jeifei Tong, Aldis Krizus, et al. "UNC-5 Function Requires Phosphorylation of Cytoplasmic Tyrosine 482, but Its UNC-40-Independent Functions also Require a Region between the ZU-5 and Death Domains." Developmental Biology 251, no. 2 (2002): 348–66. http://dx.doi.org/10.1006/dbio.2002.0825.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Starich, T. A., R. K. Herman, and J. E. Shaw. "Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion." Genetics 133, no. 3 (1993): 527–41. http://dx.doi.org/10.1093/genetics/133.3.527.

Full text

Abstract:

Abstract Mutations in the Caenorhabditis elegans gene unc-7 confer an uncoordinated phenotype. Wild-type animals trace smooth, sinuous waves as they move; unc-7 mutants make irregular bends or kinks along their bodies, particularly when they move forward. The unc-7 locus has also been implicated in the nematode's response to volatile anesthetics. We have cloned unc-7 by transposon tagging: an unc-7 mutation was correlated with the insertion of the transposon Tc1, and reversion of the mutant phenotype was correlated with loss of the Tc1 element. We have physically mapped the region flanking the

APA, Harvard, Vancouver, ISO, and other styles

30

Branchford, Brian R., Luke Law, Susan Sather, et al. "A Small Molecule Inhibitor of the Gas6/Mer Pathway Inhibits Platelet Activation and Thrombosis with Equal Efficacy to, but Greater Potency Than, iMer, the Novel MerTK Splice Variant." Blood 120, no. 21 (2012): 3303. http://dx.doi.org/10.1182/blood.v120.21.3303.3303.

Full text

Abstract:

Abstract Abstract 3303 Background: Growth Arrest Specific gene 6 (Gas6) signals through platelet-surface Mer receptors, leading to platelet activation and thrombus stabilization via activation of PI3K and Akt, and β3 integrin phosphorylation. This amplifies outside-in signaling via αIIb β3, a necessary step for stable platelet aggregation. iMer is a truncated form of the Mer receptor tyrosine kinase's extracellular domain, produced by alternative splicing, that inhibits Gas6 signaling. A selective UNC Mer small molecule inhibitor (UNC Mer TKI) inhibits signaling by inhibiting Mer tyrosine phos

APA, Harvard, Vancouver, ISO, and other styles

31

Ackerman, Susan L., Leslie P. Kozak, Stefan A. Przyborski, Laurie A. Rund, Bert B. Boyer, and Barbara B. Knowles. "The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein." Nature 386, no. 6627 (1997): 838–42. http://dx.doi.org/10.1038/386838a0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Pandey, Amita, Vipul Yadav, Aditi Sharma, Jitendra P. Khurana, and Girdhar K. Pandey. "The unc-53 gene negatively regulates rac GTPases to inhibit unc-5 activity during Distal tip cell migrations in C. elegans." Cell Adhesion & Migration 12, no. 3 (2017): 195–203. http://dx.doi.org/10.1080/19336918.2017.1345413.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Stavoe, Andrea K. H., and Daniel A. Colón-Ramos. "Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton." Journal of Cell Biology 197, no. 1 (2012): 75–88. http://dx.doi.org/10.1083/jcb.201110127.

Full text

Abstract:

Netrin is a chemotrophic factor known to regulate a number of neurodevelopmental processes, including cell migration, axon guidance, and synaptogenesis. Although the role of Netrin in synaptogenesis is conserved throughout evolution, the mechanisms by which it instructs synapse assembly are not understood. Here we identify a mechanism by which the Netrin receptor UNC-40/DCC instructs synaptic vesicle clustering in vivo. UNC-40 localized to presynaptic regions in response to Netrin. We show that UNC-40 interacted with CED-5/DOCK180 and instructed CED-5 presynaptic localization. CED-5 in turn si

APA, Harvard, Vancouver, ISO, and other styles

34

Manitt, Colleen, Cassandre Labelle-Dumais, Conrad Eng, et al. "Peri-Pubertal Emergence of UNC-5 Homologue Expression by Dopamine Neurons in Rodents." PLoS ONE 5, no. 7 (2010): e11463. http://dx.doi.org/10.1371/journal.pone.0011463.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Zarin, A. A., A. C. Daly, J. Hulsmeier, J. Asadzadeh, and J. P. Labrador. "A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor." Development 139, no. 10 (2012): 1798–805. http://dx.doi.org/10.1242/dev.070656.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Shields, Laurence, Suzanne Wiesner, Catherine Klein, Barbara Pelletreau, and Herman Hedriana. "A Standardized Approach for Category II Fetal Heart Rate with Significant Decelerations: Maternal and Neonatal Outcomes." American Journal of Perinatology 35, no. 14 (2018): 1405–10. http://dx.doi.org/10.1055/s-0038-1660459.

Full text

Abstract:

Objective To determine if a standardized intervention process for Category II fetal heart rates (FHRs) with significant decels (SigDecels) would improve neonatal outcome and to determine the impact on mode of delivery rates. Study Design Patients with Category II FHRs from six hospitals were prospectively managed using a standardized approach based on the presence of recurrent SigDecels. Maternal and neonatal outcomes were compared between pre- (6 months) and post-(11 months) implementation. Neonatal outcomes were: 5-minute APGAR scores of <7, <5, <3, and severe unexpected newborn com

APA, Harvard, Vancouver, ISO, and other styles

37

Katow, Hideki, Kouki Abe, Tomoko Katow, Hiromi Yoshida, and Masato Kiyomoto. "Involvement of Netrin/Unc-5 Interaction in Ciliary Beating and in Pattern Formation of the Ciliary Band-Associated Strand (CBAS) in the Sea Urchin, Hemicentrotus pulcherrimus." International Journal of Molecular Sciences 21, no. 18 (2020): 6587. http://dx.doi.org/10.3390/ijms21186587.

Full text

Abstract:

The GABAergic neural circuit is involved in the motile activities of both larval and juvenile sea urchins. Therefore, its function is inherited beyond metamorphosis, despite large scale remodeling of larval organs during that period. However, the initial neural circuit formation mechanism is not well understood, including how glutamate decarboxylase-expressing blastocoelar cells (GADCs) construct the neural circuit along the circumoral ciliary band (a ciliary band-associated strand, CBAS) on the larval body surface. In this study, using whole-mount immunohistochemistry and 3D reconstructed ima

APA, Harvard, Vancouver, ISO, and other styles

38

L'Hernault, S. W., G. M. Benian, and R. B. Emmons. "Genetic and molecular characterization of the Caenorhabditis elegans spermatogenesis-defective gene spe-17." Genetics 134, no. 3 (1993): 769–80. http://dx.doi.org/10.1093/genetics/134.3.769.

Full text

Abstract:

Abstract Two self-sterile mutations that define the spermatogenesis-defective gene spe-17 have been analyzed. These mutations affect unc-22 and fail to complement each other for both Unc-22 and spermatogenesis defects. Both of these mutations are deficiencies (hcDf1 and hDf13) that affect more than one transcription unit. Genomic DNA adjacent to and including the region deleted by the smaller deficiency (hcDf1) has been sequenced and four mRNAs (including unc-22) have been localized to this sequenced region. The three non unc-22 mRNAs are shown to be sex-specific: a 1.2-kb mRNA that can be det

APA, Harvard, Vancouver, ISO, and other styles

39

Otsuka, A. J., R. Franco, B. Yang, et al. "An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans." Journal of Cell Biology 129, no. 4 (1995): 1081–92. http://dx.doi.org/10.1083/jcb.129.4.1081.

Full text

Abstract:

Caenorhabditis elegans unc-44 mutations result in aberrant axon guidance and fasciculation with inappropriate partners. The unc-44 gene was cloned by transposon tagging, and verified by genetic and molecular analyses of six transposon-induced alleles and their revertants. Nucleotide sequence analyses demonstrated that unc-44 encodes a series of putative ankyrin-related proteins, including AO49 ankyrin (1815 aa, 198.8 kD), AO66 ankyrin (1867 aa, 204 kD), and AO13 ankyrin (&lt; or = 4700 aa, &lt; or = 517 kD). In addition to the major set of approximately 6 kb alternatively spliced trans

APA, Harvard, Vancouver, ISO, and other styles

40

Acevedo, Gilbert, Brian R. Branchford, Christine Brzezinski, et al. "Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo." Blood 122, no. 21 (2013): 2296. http://dx.doi.org/10.1182/blood.v122.21.2296.2296.

Full text

Abstract:

Abstract Background Growth Arrest Specific gene 6 (Gas6) is a ligand for the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases found on the surface of platelets. Previous studies have shown that stimulation of these receptors results in amplification of platelet activation and thrombus stabilization via activation of phosphatidylinositol-3-kinase (PI3K) and Akt, leading to phosphorylation of the β3 integrin. Previous work (from our lab and others) demonstrated that inhibition of the Gas6/TAM pathway results in impaired platelet aggregation, reduced aggregate stability, and decreased plat

APA, Harvard, Vancouver, ISO, and other styles

41

Brown, Heather M., Heather A. Van Epps, Alexandr Goncharov, Barth D. Grant, and Yishi Jin. "The JIP3 scaffold protein UNC-16 regulates RAB-5 dependent membrane trafficking atC. eleganssynapses." Developmental Neurobiology 69, no. 2-3 (2009): 174–90. http://dx.doi.org/10.1002/dneu.20690.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Asadzadeh, Jamshid, Niamh Neligan, Judith J. Canabal-Alvear, Amanda C. Daly, Sunita Gupta Kramer, and Juan-Pablo Labrador. "The Unc-5 Receptor Is Directly Regulated by Tinman in the Developing Drosophila Dorsal Vessel." PLOS ONE 10, no. 9 (2015): e0137688. http://dx.doi.org/10.1371/journal.pone.0137688.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Pollitt, Susan, and Gene Nichol. "DANIEL HUBBARD POLLITT." PS: Political Science & Politics 43, no. 04 (2010): 805–6. http://dx.doi.org/10.1017/s1049096510001496.

Full text

Abstract:

Daniel Hubbard Pollitt, Graham Kenan Professor of Law emeritus of the UNC-Chapel Hill School of Law died March 5, surrounded by the love of his family. Dan loved his family, the Constitution and the Bill of Rights, Holden Beach, and Tar Heel basketball.

APA, Harvard, Vancouver, ISO, and other styles

44

Starich, T. A., R. Y. Lee, C. Panzarella, L. Avery, and J. E. Shaw. "eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling." Journal of Cell Biology 134, no. 2 (1996): 537–48. http://dx.doi.org/10.1083/jcb.134.2.537.

Full text

Abstract:

The Drosophila melanogaster genes Passover and l(1)ogre and the Caenorhabditis elegans gene unc-7 define a gene family whose function is not known. We have isolated and characterized the C. elegans gene eat-5, which is required for synchronized pharyngeal muscle contractions, and find that it is a new member of this family. Simultaneous electrical and video recordings reveal that in eat-5 mutants, action potentials of muscles in the anterior and posterior pharynx are unsynchronized. Injection of carboxyfluorescein into muscles of the posterior pharynx demonstrates that all pharyngeal muscles a

APA, Harvard, Vancouver, ISO, and other styles

45

Roller, A. Brock, David C. Hoffman, and Alan M. Zahler. "The Allele-Specific Suppressor sup-39 Alters Use of Cryptic Splice Sites in Caenorhabditis elegans." Genetics 154, no. 3 (2000): 1169–79. http://dx.doi.org/10.1093/genetics/154.3.1169.

Full text

Abstract:

Abstract Mutations in the Caenorhabditis elegans sup-39 gene cause allele-specific suppression of the uncoordination defect of unc-73(e936). e936 is a point mutation that changes the canonical G at the 5′ end of intron 16 to a U. This mutation activates three splice donors, two of which define introns beginning with the canonical GU. Use of these two cryptic splice sites causes loss of reading frame; interestingly these messages are not substrates for nonsense-mediated decay. The third splice donor, used in 10% of steady-state e936 messages, is the mutated splice donor at the wild-type positio

APA, Harvard, Vancouver, ISO, and other styles

46

Hu, Xinyi, Xuejiao Liu, Longwei Lv, et al. "UNC‐5 netrin receptor B regulates adipogenesis of human adipose–derived stem cells through JNK pathway." Journal of Oral Rehabilitation 47, S1 (2020): 91–98. http://dx.doi.org/10.1111/joor.13067.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Patel, A. M., and S. D. Dunn. "RNase E-dependent cleavages in the 5' and 3' regions of the Escherichia coli unc mRNA." Journal of Bacteriology 174, no. 11 (1992): 3541–48. http://dx.doi.org/10.1128/jb.174.11.3541-3548.1992.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Li, W., R. K. Herman, and J. E. Shaw. "Analysis of the Caenorhabditis elegans axonal guidance and outgrowth gene unc-33." Genetics 132, no. 3 (1992): 675–89. http://dx.doi.org/10.1093/genetics/132.3.675.

Full text

Abstract:

Abstract Mutations in the unc-33 gene of the nematode Caenorhabditis elegans lead to severely uncoordinated movement, abnormalities in the guidance and outgrowth of the axons of many neurons, and a superabundance of microtubules in neuronal processes. We have cloned unc-33 by tagging the gene with the transposable element Tc4. Three unc-33 messages, which are transcribed from a genomic region of at least 10 kb, were identified and characterized. The three messages have common 3' ends and identical reading frames. The largest (3.8-kb) message consists of the 22-nucleotide trans-spliced leader S

APA, Harvard, Vancouver, ISO, and other styles

49

Stuart, Anita D., H. Gertie Pretorius, and Lynette Van der Merwe. "Irritable bowel syndrome: towards an integrated approach." Health SA Gesondheid 4, no. 1 (1999): 45–46. http://dx.doi.org/10.4102/hsag.v4i1.12.

Full text

Abstract:

Functional Gastrointestinal Disorders are defined as chronic or recurrent gastrointestinal symptoms characterized by abdominal pain, constipation and/or diarrhoea (Tally, 1994; University of North Carolina, 1998). These disorders are of concern because of their high incidence, associated morbidity, expense and the impact of these disorders on people's quality of life. Drossman (1993, in University of North Carolina (UNC), 1998) found that of 5 400 U.S. households, 69% of people met the criteria for at least one of the functional gastrointestinal disorders which represents a 59% increase in the

APA, Harvard, Vancouver, ISO, and other styles

50

De Stasio, Elizabeth, Catherine Lephoto, Lynn Azuma, Charles Holst, Dinesh Stanislaus, and Jai Uttam. "Characterization of Revertants of unc-93(e1500) in Caenorhabditis elegans Induced by N-ethyl-N-nitrosourea." Genetics 147, no. 2 (1997): 597–608. http://dx.doi.org/10.1093/genetics/147.2.597.

Full text

Abstract:

Phenotypic reversion of the rubber-band, muscle-defective phenotype conferred by unc-93(e1500) was used to determine the utility of N-ethyl-N-nitrosourea (ENU) as a mutagen for genetic research in Caenorhabditis elegans. In this system, ENU produces revertants at a frequency of 3 × 10–4, equivalent to that of the commonly used mutagen, EMS. The gene identity of 154 ENU-induced revertants shows that the distribution of alleles between three possible suppressor genes differs from that induced by EMS. A higher percentage of revertants are alleles of unc-93 and many fewer are alleles of sup-9 and

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!