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Dissertations / Theses on the topic 'Uncomplicated malaria'

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1

Kofoed, Poul-Erik. "Treatment of uncomplicated malaria in Guinea-Bissau /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-698-0/.

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2

Huot, Chantheany Pornthep Chanthavanich. "Clinical manifestation of uncomplicated falciparum malaria and vivax malaria in Thai children /." Abstract, 2004. http://mulinet3.li.mahidol.ac.th/thesis/2547/cd363/4638516.pdf.

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3

Distiller, G. B. "Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malaria." Master's thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/4378.

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4

Anyorigiya, Thomas Atingane. "Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27301.

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RATIONALE: The accurate measurement of antimalarial drug concentrations in key target patient groups is essential to ensure optimal dosing for malaria treatment and to distinguish between inadequate drug exposure and antimalarial resistance. METHODS: A sensitive and selective liquid chromatography-tandem mass spectrophotometric method was developed and validated for the simultaneous determination of amodiaquine and its active metabolite, desethylamodiaquine in 20μl heparinised human capillary whole blood and capillary plasma. During validation no significant matrix effects were observed for th
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5

Wilkins, Justin. "A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga." Master's thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26763.

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Following the completion of a detailed baseline study of malaria in the region, a model was developed to assess the cost-effectiveness of switching from chloroquine to sulfadoxine-pyrimetharnine as first line treatment in the Tonga district of Mpumalanga, South Africa, where malaria is seasonal and the population is non-immune. In vivo drug resistance was used to create a resistance variable, which was used to assess the 1997 relative costs to the health care system of employing the two drugs, analysing factors such as drug costs, staff time, transport costs, maintenance costs, utility costs,
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6

Nguyen, The Trong [Verfasser], and Benjamin [Akademischer Betreuer] Mordmüller. "Development and implementation of molecular methods to genotype Plasmodium falciparum in uncomplicated malaria and severe malarial anemia in Gabon / The Trong Nguyen ; Betreuer: Benjamin Mordmüller." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1206933755/34.

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7

Okungu, Vincent Robert. "Public responses to policy changes in 1st line treatment for uncomplicated for malaria in Kenya and the potential influence of policy communication in the uptake of malaria drugs." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/9452.

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Includes bibliographical references.<br>This study intends to give new insights into community perceptions on policy changes in 1st-line treatment for uncomplicated malaria in Kenya and the contributions of such perceptions on the uptake of recommended malaria drugs. It also intends to promote effective communication and implementation of malaria treatment policies and highlight public concerns about drug policy changes, and finally, add to the literature on malaria control and contribute to policy debates from a community perspective.
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8

Duarte, Elisabeth Carmen. "Randomized controlled trial of artesunate plus tetracycline versus standard treatment (quinine plus tetracycline) for uncomplicated plasmodium falciparum malaria in Brazil." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55491.

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A triple blind randomized controlled trial was undertaken in a Brazilian Amazon region (Cuiaba-MT), to compare the effectiveness and side effects of oral artesunate (7 days, total dose = 0.75 g) plus tetracycline (7 days, total dose = 10.5 g) (AT) and oral quinine (3 days, total dose = 6 g) plus tetracycline (7 days, total dose = 10.5 g) (QT). Eligible patients had uncomplicated P. falciparum malaria; age $ geq$ 14 years; no previous malaria treatment related to the present attack; and, if women, indication of absence of pregnancy. Clinical exam and blood tests were performed at baseline (day
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9

Allen, Elizabeth. "Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial." Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/9321.

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Includes bibliographical references (leaves 83-88).<br>[Background and rationale] Malaria accounts for a large public health burden in Mozambique and a treatment policy with effective anti-malarials is a key component of their malaria control programme. Artemisinin-based combination therapies (ACTs) are now generally considered as the best treatment for uncomplicated falciparum malaria; the use of artesunate (AS) in combination with sulfadoxine-pyrimethamine (SP) is recommended by the World Health Organisation (WHO). Mozambique policy-makers recommended that an ACT be implemented and studied i
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10

Rahman, Mushfiqur Pratap Singhasivanon. "The effect of adherence on the efficacy of artemether-lumefantrine (coartem) in the treatment of uncomplicated plasmodium falciparum Malaria in Bangladesh : a randomized controlled trial /." Abstract, 2007. http://mulinet3.li.mahidol.ac.th/thesis/2550/cd419/4738054.pdf.

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11

Marschallek, Maria Rebekka [Verfasser], and Steffen [Akademischer Betreuer] Borrmann. "Surveillance of artemisinin and partner drug efficacy in uncomplicated Plasmodium falciparum malaria in Coastal Kenya / Maria Rebekka Marschallek ; Betreuer: Steffen Borrmann." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1167243595/34.

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12

Sievers, Moritz [Verfasser]. "Efficacy, tolerability and safety of fosmidomycin and piperaquine as a non-artemisinin combination therapy in children with uncomplicated malaria / Moritz Sievers." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1240673302/34.

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13

Janha, Ramatoulie. "Effects of inactive CYP2C19/Cyp2C9 alleles on chlorproguanil pharmacokinetics in adults and treatment outcome in children with uncomplicated malaria following lapdap (R) treatment." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533125.

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14

Diallo, Diadier Amadou. "A study of the impact of insecticide-treated curtains on the prevalence of antimalarial drug resistance in children with uncomplicated malaria in Burkina Faso." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421884.

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15

Nicklous, Raffaella Amber [Verfasser]. "Analysing treatment failures by high-resolution capillary electrophoresis genotyping in uncomplicated P. falciparum malaria adapted from patient samples from Bobo-Dioulasso, Burkina Faso / Raffaella Amber Nicklous." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1227771916/34.

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16

Seck, Ibrahima. "The Effectiveness of Home Based Management of Uncomplicated Malaria Using Artemisinin Combination Treatments (ACTs) and Rapid Diagnostic Tests (RDTs) in Rural Senegal (West Africa)| Pilot Study in Three Districts." Thesis, Tulane University, Payson Center for International Development, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10257455.

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<p> <b>Introduction:</b> The Home-based Management of Malaria (HMM) is a cornerstone of malaria control in sub-Saharan Africa (SSA) and is recommended by WHO to provide prompt access to antimalarial treatment for children in under-served areas. Although HMM has been shown to reduce malaria morbidity and mortality with chloroquine, it has not been examined previously in the era of artemisinin-based combination therapies. The objectives of this study were to determine whether HMM reduced: 1] the time from when a mother or guardian realized her child was ill to the time when the child was brought
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17

TEKETE, Mamadou Modibo [Verfasser], and Walter Emil [Akademischer Betreuer] Haefeli. "Day 7 concentration effects of partner drugs of artemisinin and derivatives on recurrent episodes of uncomplicated Plasmodium falciparum malaria after repetitive treatment with the same drug during two years in Mali / Mamadou Modibo TEKETE ; Betreuer: Walter Emil Haefeli." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1222830426/34.

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18

Tekete, Mamadou [Verfasser], and Walter E. [Akademischer Betreuer] Haefeli. "Day 7 concentration effects of partner drugs of artemisinin and derivatives on recurrent episodes of uncomplicated Plasmodium falciparum malaria after repetitive treatment with the same drug during two years in Mali / Mamadou Modibo TEKETE ; Betreuer: Walter Emil Haefeli." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-274574.

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19

Tekete, Mamadou [Verfasser], and Walter Emil [Akademischer Betreuer] Haefeli. "Day 7 concentration effects of partner drugs of artemisinin and derivatives on recurrent episodes of uncomplicated Plasmodium falciparum malaria after repetitive treatment with the same drug during two years in Mali / Mamadou Modibo TEKETE ; Betreuer: Walter Emil Haefeli." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1222830426/34.

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20

Losimba, Likwela Joris. "Contribution à l'amélioration de la lutte contre le paludisme en République Démocratique du Congo, RDC." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209737.

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Deuxième pays le plus endémique pour le paludisme au monde, la république démocratique du Congo (RDC) a adopté officiellement l’initiative Faire Reculer le Paludisme en 2001 et depuis, aligne sa politique de lutte contre le paludisme sur les directives de l’OMS dont les orientations les plus récentes consistent en 3 stratégies :[1] assurer aux malades un accès rapide à un traitement efficace et abordable, [2] assurer aux personnes exposées au risque, notamment les jeunes enfants et les femmes enceintes, l’association la plus adaptée de mesures de protection au niveau personnel et communautaire
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21

Salazar, Pablo de [Verfasser], and Peter [Akademischer Betreuer] Kremsner. "A clinical phase III comparative, randomised, clinical trial to assess the safety and efficacy of a fixed dose of oral pyronaridine-artesunate granule formulation (60 : 20) (paediatric Pyramax®) versus artemether-lumefantrine (Coartem®) crushed tablets in infants and children with acute uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon / Pablo de Salazar ; Betreuer: Peter G. Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199615153/34.

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22

Salazar, Pablo de Verfasser], and Peter [Akademischer Betreuer] [Kremsner. "A clinical phase III comparative, randomised, clinical trial to assess the safety and efficacy of a fixed dose of oral pyronaridine-artesunate granule formulation (60 : 20) (paediatric Pyramax®) versus artemether-lumefantrine (Coartem®) crushed tablets in infants and children with acute uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon / Pablo de Salazar ; Betreuer: Peter G. Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199615153/34.

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23

Benido, Impouma. "A meta-analysis of artesunate plus sulfadoxinepyrimethamine alone for treatment of uncomplicated malaria in children." Thesis, 2006. http://hdl.handle.net/10539/1835.

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Faculty of Health Science School of Public Health 0418444d benido_impouma@yahoo.com<br>Study objectives The objective of this meta-analysis was to review the comparative efficacy and tolerance of sulfadoxine-pyrimethamine (SP) given alone or in combination with one (SPAS1) or three (SPAS3) doses of artesunate in children with uncomplicated P. falciparum malaria, aged 6 months to 10 years. Specifically, it assessed cure rate, fever and parasite clearance time, gametocyte carriage and tolerability. Methods The methodology used was a systematic review and a meta-analysis of four random
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24

Mngomezulu, Nicros Magangeni. "The role of mutations in uncomplicated Plasmodium falciparum malaria and sulfadoxine pyrimethamine efficacy in Mpumalanga Province, South Africa." Thesis, 2006. http://hdl.handle.net/10539/1829.

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Faculty of Science School of Animal,Plant,Enviromental Sciences 0311595p NicrosM@social.mpu.gov.za<br>The antifolate combination of sulfadoxine and pyrimethamine (SP) is one of few remaining affordable drug combinations available for wide-scale treatment of uncomplicated Plasmodium falciparum malaria in Africa. In vivo studies of SP efficacy conducted during 1998, 2000 and 2002 at the Naas sentinel site in Mpumalanga province, South Africa, demonstrated a gradual non-significant increase in late treatment failure (LTF) and early treatment failure (ETF) resistance to SP, while gametocyte car
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25

Vaughan-Williams, Charles Hervey. "Assessment of the therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in northern KwaZulu-Natal." Thesis, 2013. http://hdl.handle.net/10413/11064.

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Background Recent malaria epidemics in KwaZulu-Natal indicate that effective anti-malarial therapy is essential for malaria control. Although artemether-lumefantrine has been used as firstline treatment for uncomplicated Plasmodium falciparum malaria in northern KwaZulu- Natal since 2001, its efficacy has not been assessed since 2002. The objectives of this study were to quantify the proportion of patients treated for uncomplicated P. falciparum malaria with artemether-lumefantrine who failed treatment after 28 days, and to determine the prevalence of molecular markers associated with artemeth
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26

"The Effectiveness of Home Based Management of Uncomplicated Malaria Cases Using Artemisinin Combination Treatments (ACTs) and Rapid Diagnostic Tests (RDTs) in Rural Senegal (West Africa): Pilot Study in Three Districts." Tulane University, 2017.

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acase@tulane.edu<br>Introduction: The Home-based Management of Malaria (HMM) is a cornerstone of malaria control in sub-Saharan Africa (SSA) and is recommended by WHO to provide prompt access to antimalarial treatment for children in under-served areas. Although HMM has been shown to reduce malaria morbidity and mortality with chloroquine, it has not been examined previously in the era of artemisinin-based combination therapies. The objectives of this study were to determine whether HMM reduced: 1] the time from when a mother or guardian realized her child was ill to the time when the child wa
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27

Zani, Babalwa. "The efficacy and safety of artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria in non-pregnant adults and children : a systematic review." Thesis, 2011. http://hdl.handle.net/10413/10009.

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Effective case management of malaria is hampered by the spread of parasite resistance to nonartemisinin antimalarials. To counteract the impact of drug resistance, the World Health Organization (WHO) has endorsed artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated Plasmodium falciparum malaria. Currently recommended ACTs are artemether-lumefantrine, artesunate plus amodiaquine, artesunate plus mefloquine, artesunate plus sulfadoxine-pyrimethamine and dihydroartemisinin-piperaquine. This study sought to review evidence of the efficacy and safety of differen
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28

Schreier, Annette Christina [Verfasser]. "Pyronaridine-Artesunate combination for the treatment of acute uncomplicated Plasmodium falciparum malaria in paediatric patients in Gabon / vorgelegt von Annette Christina Schreier." 2010. http://d-nb.info/100148424X/34.

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29

Kurth, Florian Michael [Verfasser]. "Pharmacokinetic characteristics of two paediatric formulations of Artesunate-Mefloquine in African children with acute uncomplicated plasmodium falciparum Malaria / vorgelegt von Florian Michael Kurth." 2009. http://d-nb.info/992638615/34.

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30

Bélard, Sabine Miriam [Verfasser]. "Efficacy, safety, tolerability and acceptability of two pediatric formulations of artesunate-mefloquine in African children with acute uncomplicated Plasmodium falciparum malaria / vorgelegt von Sabine Miriam Bélard." 2008. http://d-nb.info/987985221/34.

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