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Journal articles on the topic 'Uncomplicated malaria'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Parikh, Harvy, Ravi Shah, Nilesh Doctor, and Hemant Shah. "A study of serum calcium level in cases of malaria in a tertiary care hospital." International Journal of Advances in Medicine 8, no. 12 (2021): 1827. http://dx.doi.org/10.18203/2349-3933.ijam20214518.

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Background: Malaria is a tropical disease caused by Plasmodium species, commonly P. falciparum and P. vivax. Carpopedal spasm has been noted in many patients presenting with malarial fever. Most of the patients are later found to have hypocalcaemia. Hypocalcaemia associated with malaria can cause many clinical manifestations, including life threatening conditions such as arrhythmias, convulsions etc.Methods: A cross-sectional study was conducted with the aim to determine the prevalence and clinical profile of hypocalcaemia in different types of malarial fever. 88 patients of malarial fever wer

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2

Mandala, Wilson L., Chisomo L. Msefula, Esther N. Gondwe, et al. "Lymphocyte Perturbations in Malawian Children with Severe and Uncomplicated Malaria." Clinical and Vaccine Immunology 23, no. 2 (2015): 95–103. http://dx.doi.org/10.1128/cvi.00564-15.

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ABSTRACTLymphocytes are implicated in immunity and pathogenesis of severe malaria. Since lymphocyte subsets vary with age, assessment of their contribution to different etiologies can be difficult. We immunophenotyped peripheral blood from Malawian children presenting with cerebral malaria, severe malarial anemia, and uncomplicated malaria (n= 113) and healthy aparasitemic children (n= 42) in Blantyre, Malawi, and investigated lymphocyte subset counts, activation, and memory status. Children with cerebral malaria were older than those with severe malarial anemia. We found panlymphopenia in chi

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Kotepui, Kwuntida Uthaisar, Pattamaporn Kwankaew, Frederick Ramirez Masangkay, Aongart Mahittikorn та Manas Kotepui. "Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis". Tropical Medicine and Infectious Disease 7, № 10 (2022): 299. http://dx.doi.org/10.3390/tropicalmed7100299.

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Transforming growth factor-β (TGF-β) is important in the pathophysiology of malaria, but its role in acute and severe malaria is largely unknown. As a result, this study used a meta-analysis approach to investigate the difference in TGF-β levels between several groups of malaria patients and healthy controls. The systematic review protocol was registered at PROSPERO (ID: CRD42022318864). From inception to 7 March 2022, studies that reported TGF-β levels in patients with uncomplicated and healthy controls and patients with severe and uncomplicated malaria were searched in PubMed, Scopus and Emb

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O.A., Elakhe, Isere A.O., and Akerejola R.F. "Mathematical Model of Malaria Transmission with Anti-Malarial Herbal Therapy as Control." African Journal of Mathematics and Statistics Studies 6, no. 3 (2023): 1–16. http://dx.doi.org/10.52589/ajmss-1276jr4u.

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Conventional anti–malarial drugs (chloroquine, Artesunate, Quinine, Amodiaquine etc) are used by most malaria-endemic countries as first-line treatment for uncomplicated malaria. However, resistance by plasmodium parasite against these conventional anti–malarial drugs has necessitated the need for herbal medicine as alternative. So in this study, we formulate a mathematical model of malaria transmission in two interacting population of human (host) and mosquito (vector) incorporating anti-malarial herbal therapy as first line treatment for uncomplicated malaria infection. The region where the

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Lyke, Kirsten E., Robin B. Burges, Yacouba Cissoko, et al. "HLA-A2 Supertype-Restricted Cell-Mediated Immunity by Peripheral Blood Mononuclear Cells Derived from Malian Children with Severe or Uncomplicated Plasmodium falciparum Malaria and Healthy Controls." Infection and Immunity 73, no. 9 (2005): 5799–808. http://dx.doi.org/10.1128/iai.73.9.5799-5808.2005.

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ABSTRACT Understanding HLA-restricted adaptive host immunity to defined epitopes of malarial antigens may be required for the development of successful malaria vaccines. Fourteen epitopes of preerythrocytic malarial antigens known to mediate cytotoxic T-lymphocyte responses against target cells expressing HLA-A2-restricted epitopes were synthesized and pooled based on antigen: thrombospondin-related anonymous protein (TRAP), circumsporozoite protein (CSP), and export protein 1 (Exp-1) peptides. HLA-A2 supertype (*0201, *0202, *0205, *6802) peripheral blood mononuclear cells collected from 774

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Gordeuk, Victor R., Ishmael Kasvosve, Janneke van Dijk, et al. "Altered Immune Response in Severe Malaria Anemia in Children." Blood 108, no. 11 (2006): 1303. http://dx.doi.org/10.1182/blood.v108.11.1303.1303.

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Abstract We prospectively assessed immune markers in children &lt;6 years with severe malarial anemia (hemoglobin &lt;5.0 g/dL; n = 72) and uncomplicated malaria (n = 69) who presented to Macha Mission Hospital in Zambia’s Southern Province. We also studied 70 children &lt;6 years who presented to well child clinics in Harare, Zimbabwe as controls. Compared to controls, children with uncomplicated malaria had significantly higher temperatures and parasite counts, lower hemoglobin and platelet concentrations, higher plasma levels of interferon-gamma, tumor necrosis factor alpha, and

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Mahittikorn, Aongart, Kwuntida Uthaisar Kotepui, Wanida Mala, Polrat Wilairatana, and Manas Kotepui. "Procalcitonin as a Candidate Biomarker for Malarial Infection and Severe Malaria: A Meta-Analysis." International Journal of Environmental Research and Public Health 19, no. 18 (2022): 11389. http://dx.doi.org/10.3390/ijerph191811389.

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Procalcitonin (PCT), as a marker of malaria severity, remains to be investigated. The present study collated and compared the levels of PCT between patients with severe malaria, uncomplicated malaria, and control participants to assess their role in predicting malaria infection and disease severity. The systematic review was registered at PROSPERO with registration number CRD42021297243. The search for relevant studies that reported PCT in patients with malaria was performed in PubMed, Scopus, and Web of Science. The following meta-analyses were conducted; (1) the pooled mean PCT levels in pat

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Meremikwu, M., F. Odey, C. Oringanje, et al. "Effectiveness of a 6-dose regimen of Artemether-Lumefantrine for unsupervised treatment of uncomplicated childhood malaria in Calabar, Nigeria." Nigerian Journal of Paediatrics 40, no. 2 (2013): 145–49. http://dx.doi.org/10.4314/njp.v40i2.7.

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Background: The six dose regimen of Artemether- Lumefantrine (AL), has high efficacy in clinical trials and is the first -line drug for treating uncomplicated malaria in Nigeria. The complex dosage schedule could militate against its effectiveness.Objective: To assess the effectiveness of AL prescribed under routineoutpatient conditions in the treatment of uncomplicated malaria.Methods: An open label, noncomparative trial to assess the effectivenessof AL in children 6 to 59 months with uncomplicated P. falciparum and parasite density between 1,000 and 250,000/ìL. Enrolled children received 6-d

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Lwanira, Catherine N., Fred Kironde, and Göte Swedberg. "Haptoglobin gene diversity and incidence of uncomplicated malaria among children in Iganga, Uganda." Malaria Journal 19, no. 1 (2020): 435. https://doi.org/10.1186/s12936-020-03515-y.

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<strong>Background: </strong>Haptoglobin (Hp) is an acute phase protein that takes part in systemic regulation of haem during <i>Plasmodium falciparum</i> infections. Numerous genotypes of haptoglobin have been reported in malaria endemic populations. In this study, the relationship between haptoglobin genotypes and incidence of uncomplicated malaria in a cohort of children living in a malaria-endemic area of Uganda was determined.<strong>Methods: </strong>This is an extension of a longitudinal study comprising of 423 children aged between six months and nine years, who were actively followed

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10

Toovey, Stephen. "Treatment of uncomplicated malaria." Transactions of the Royal Society of Tropical Medicine and Hygiene 96, no. 5 (2002): 573. http://dx.doi.org/10.1016/s0035-9203(02)90447-5.

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Nsiah, Kwabena, Bernard Bahaah, Bright Oppong Afranie, Simon Koffie, Emmanuel Akowuah, and Sampson Donkor. "Oxidative Stress and Hemoglobin Level of Complicated and Uncomplicated Malaria Cases among Children: A Cross-Sectional Study in Kumasi Metropolis, Ghana." Journal of Tropical Medicine 2019 (July 7, 2019): 1–6. http://dx.doi.org/10.1155/2019/8479076.

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Introduction. Malaria is a leading cause of mortality among children below 5 years in Ghana. Its parasites are known to cause the degradation of hemoglobin, resulting in the production of reactive oxygen species and hence oxidant stress. Therefore, this study was carried out to compare the levels of oxidative stress between children with complicated and uncomplicated malaria infection in Kumasi, Ghana. Method. Subjects were recruited from hospitals in the Kumasi Metropolis. This was a cross-sectional study, involving 17 complicated malaria subjects, 51 uncomplicated malaria subjects, and 15 no

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Castelino, Dipthi Nishal, and K. Shreedhara Avabratha. "C-reactive protein levels in children with uncomplicated malaria." International Journal of Contemporary Pediatrics 4, no. 2 (2017): 573. http://dx.doi.org/10.18203/2349-3291.ijcp20170712.

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Background: Malaria is one of the biggest burden in terms of morbidity and mortality among all infectious diseases and continues to be a major health problem in India. The objective of this study was to study the levels of C-reactive protein in children with uncomplicated Malaria. To correlate C-reactive protein levels with malaria parasite density and species of Malaria.Methods: Retrospective study was done in Father Muller Medical College, Mangalore, Karnataka. 50 patients below 15 years of age malaria parasite positive by fluorescent test (MPFT) and by Peripheral smear formed the subjects a

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Nanyunja, Miriam, Juliet Nabyonga Orem, Frederick Kato, Mugagga Kaggwa, Charles Katureebe, and Joaquim Saweka. "Malaria Treatment Policy Change and Implementation: The Case of Uganda." Malaria Research and Treatment 2011 (September 19, 2011): 1–14. http://dx.doi.org/10.4061/2011/683167.

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Malaria due to P. falciparum is the number one cause of morbidity and mortality in Uganda where it is highly endemic in 95% of the country. The use of efficacious and effective antimalarial medicines is one of the key strategies for malaria control. Until 2000, Chloroquine (CQ) was the first-line drug for treatment of uncomplicated malaria in Uganda. Due to progressive resistance to CQ and to a combination of CQ with Sulfadoxine-Pyrimethamine, Uganda in 2004 adopted the use of ACTs as first-line drug for treating uncomplicated malaria. A review of the drug policy change process and postimpleme

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Jimam, Nanloh Samuel, and Nahlah Elkudssiah Ismail. "Predictors of patients' knowledge, attitudes and practices (KAP) regarding uncomplicated malaria in the primary healthcare facilities of Plateau state, Nigeria." Journal of Health Research 34, no. 4 (2020): 329–44. http://dx.doi.org/10.1108/jhr-06-2019-0125.

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PurposeThis study determined factors that influenced patients' knowledge, attitudes and practices (KAP) regarding uncomplicated malaria in primary healthcare (PHC) facilities of Plateau state, Nigeria.Design/methodology/approachThe data of 956 patients treated for uncomplicated malaria in PHC facilities of Plateau state were used for the study. Inferential statistical analyses were conducted to identify factors that influenced patients' KAP on the disease and its management.FindingsThe study revealed age (p < 0.001), level of education (p = 0.012), attitudes (p = 0.007) and practices (p &lt

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Jumba, Bernard Ngoitsi, Mark Webale, Judith Makwali, and Nathan Shaviya. "Red blood cell indices and cytokine levels in complicated pediatric Malaria in unstable malaria transmission area of Vihiga highlands, Kenya." Journal of Hematology and Allied Sciences 4 (June 20, 2024): 38–45. http://dx.doi.org/10.25259/jhas_7_2024.

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Objectives: Complicated pediatric Malaria in unstable transmission regions presents a significant health challenge, necessitating a comprehensive understanding of the associated hematological and immunological alterations. This study aimed to investigate the hematological parameters, chemokine and cytokine response in children with complicated Malaria in an unstable malaria transmission region. Material and Methods: This cross-sectional study was conducted in Vihiga County, Western Kenya, a highland area with unstable malaria transmission. Three hundred and nine children with varied malaria ph

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Mathur, Dr Priyanshu, Dr Pankaj Kumar Jain, and Dr B. D. Gupta. "Chloroquine Vs Co-Artemether in Uncomplicated Malaria." Scholars Journal of Applied Medical Sciences 4, no. 6 (2016): 1981–85. http://dx.doi.org/10.21276/sjams.2016.4.6.22.

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Bisanzio, Donal, Mamadou Sitan Keita, Alioune Camara, et al. "Malaria trends in districts that were targeted and not-targeted for seasonal malaria chemoprevention in children under 5 years of age in Guinea, 2014–2021." BMJ Global Health 9, no. 2 (2024): e013898. http://dx.doi.org/10.1136/bmjgh-2023-013898.

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BackgroundSeasonal malaria chemoprevention (SMC) is a main intervention to prevent and reduce childhood malaria. Since 2015, Guinea has implemented SMC targeting children aged 3–59 months (CU5) in districts with high and seasonal malaria transmission.ObjectiveWe assessed the programmatic impact of SMC in Guinea’s context of scaled up malaria intervention programming by comparing malaria-related outcomes in 14 districts that had or had not been targeted for SMC.MethodsUsing routine health management information system data, we compared the district-level monthly test positivity rate (TPR) and m

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Wilairatana, Polrat, Pattamaporn Kwankaew, Kwuntida Uthaisar Kotepui, and Manas Kotepui. "Low Interleukin-12 Levels concerning Severe Malaria: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 19, no. 15 (2022): 9345. http://dx.doi.org/10.3390/ijerph19159345.

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Although many studies have investigated the role of interleukin (IL)-12 cytokine in the pathogenesis of severe malaria, these studies were based on a limited number of participants, possibly affecting their outcomes. We analyzed the difference in IL-12 levels between patients with severe and uncomplicated malaria through a meta-analysis. A systematic review was conducted following the Cochrane Handbook for Systematic Reviews of Interventions and was reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. Systematic literature searches were perfor

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Bartoloni, Alessandro, and Lorenzo Zammarchi. "CLINICAL ASPECTS OF UNCOMPLICATED AND SEVERE MALARIA." Mediterranean Journal of Hematology and Infectious Diseases 4, no. 1 (2012): e2012026. http://dx.doi.org/10.4084/mjhid.2012.026.

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The first symptoms of malaria, common to all the different malaria species, are nonspecific and mimic a flu-like syndrome. Although fever represents the cardinal feature, clinical findings in malaria are extremely diverse and may range in severity from mild headache to serious complications leading to death, particularly in falciparum malaria. As the progression to these complications can be rapid, any malaria patient must be assessed and treated rapidly, and frequent observations are needed to look for early signs of systemic complications.In fact, severe malaria is a life threatening but tre

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Laurens, Matthew B. "The Immunologic Complexity of Growing Up with Malaria—Is Scientific Understanding Coming of Age?" Clinical and Vaccine Immunology 23, no. 2 (2015): 80–83. http://dx.doi.org/10.1128/cvi.00697-15.

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ABSTRACTIn the current issue ofClinical and Vaccine Immunology, Mandala et al. report changes in lymphocyte populations in children with uncomplicated malaria, severe malarial anemia, and cerebral malaria compared to controls (W. L. Mandala et al., Clin Vaccine Immunol 23:95–103, 2016,http://dx.doi.org/10.1128/CVI.00564-15). This commentary discusses the importance of understanding both helpful and detrimental aspects of the antimalarial immune response that are critical to malaria vaccine development and considers how these responses may relate to antimalarial vaccine safety and efficacy.

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Oluboyo, A. O., S. I. Chukwu, B. O. Oluboyo, and O. O. Odewusi. "Evaluation of Angiopoietins 1 and 2 in Malaria-Infested Children." Journal of Environmental and Public Health 2020 (May 26, 2020): 1–5. http://dx.doi.org/10.1155/2020/2169763.

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Background. Malaria could affect people of all ages, most especially young children. The study evaluated the levels of serum angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) which are critical regulators of endothelial activation and integrity with some hematological parameters (total white blood cell counts (WBC), total red blood cell counts (RBC), platelet counts, and malaria parasite density) in malaria-infected children. Method. A total of 92 blood samples from children between the ages of 6 months to 15 years were analyzed. The samples consisted of 30 cases of severe malaria, 40 cases of

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Hitesh, Patel, Patel Dipa, Chugh Sawan, and Thakkar Ramkumar. "Prevalence of Malarial Retinopathy in Adults and its Prognostic Significance." International Journal of Pharmaceutical and Clinical Research 15, no. 7 (2023): 1001–6. https://doi.org/10.5281/zenodo.11672431.

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<strong>Introduction: </strong>Malarial retinopathy is a set of retinal signs in severe malaria due to falciparum malaria. It includes papilloedema, retinal hemorrhages, blurred disc margins, retinal whitening, retinal edema, vascular changes and soft exudates. <strong>Materials & Methods: </strong>This prospective study included retinal examination of 124 adult malaria patients admitted to tertiary care hospital. Retinal haemorrhages and vascular changes, papilloedema, peripheral whitening, and blurring of the disc borders were noted, <strong>Results: </strong>Pre

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Kuraeiad, Saruda, Kwuntida Uthaisar Kotepui, Aongart Mahittikorn та ін. "A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity". Medicina 61, № 4 (2025): 676. https://doi.org/10.3390/medicina61040676.

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Background and Objectives: Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β act as signaling molecules that recruit immune cells to sites of infection and inflammation. This study aimed to synthesize evidence on blood levels of MIP-1α and MIP-1β in Plasmodium-infected individuals and to determine whether these levels differ between severe and uncomplicated malaria cases. Materials and Methods: The study protocol was registered in PROSPERO (CRD42024595818). Comprehensive literature searches were conducted in six databases (EMBASE, MEDLINE, Ovid, Scopus, ProQuest, and PubMed) to identify s

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Amoako-Sakyi, Daniel, Selorme Adukpo, Kwadwo A. Kusi, et al. "A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children." Genetics & Epigenetics 8 (January 2016): GEG.S38307. http://dx.doi.org/10.4137/geg.s38307.

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Malaria pathogenesis may be influenced by IgE responses and cytokine cross-regulation. Several mutations in the IL-4/STAT6 signaling pathway can alter cytokine cross-regulation and IgE responses during a Plasmodium falciparum malarial infection. This study investigated the relationship between a STAT6 intronic single-nucleotide polymorphism (rs3024974), total IgE, cytokines, and malaria severity in 238 Ghanaian children aged between 0.5 and 13 years. Total IgE and cytokine levels were measured by ELISA, while genotyping was done by polymerase chain reaction-restriction fragment length polymorp

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Patrocínio-Jesus, Rita, João Cunha, Diva Trigo, Bárbara Flor-de-Lima, and Patrícia Pacheco. "Artemether/Lumefantrine for the Treatment of P. malariae in a Patient on Hemodialysis." Case Reports in Medicine 2019 (February 12, 2019): 1–2. http://dx.doi.org/10.1155/2019/1326171.

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The combination of artemether/lumefantrine is indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria. There have been no clinical trials to assess the efficacy of this medication in patients with renal impairment. While it is unlikely that artemether/lumefantrine would be removed during dialysis, clinical experience regarding drug use in this setting is limited. In this article, the authors report successful treatment of Plasmodium malariae malaria on a patient with end-stage kidney disease undergoing hemodialysis.

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Ismail, Nahlah Elkudssiah, Nanloh Samuel Jimam, Khang Wen Goh, Ching Siang Tan, and Long Chiau Ming. "Economic Burdens of Uncomplicated Malaria in Primary Health Care (PHC) Facilities of Plateau State, Nigeria: Patients’ Perspectives." International Journal of Environmental Research and Public Health 20, no. 2 (2023): 1093. http://dx.doi.org/10.3390/ijerph20021093.

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Objectives: This study aims at evaluating the costs incurred by patients in Primary Healthcare facilities of Plateau State, Nigeria, due to uncomplicated malaria management. Methods: Patients’ information on resources used and absence from the labour market due to uncomplicated malaria illness were collected using the self-reported cost of illness instruments across 24 selected Primary Health Care (PHC) facilities in Plateau State. The collated data were used to estimate the direct medical and non-medical costs incurred by patients through the summation of the various costs paid out of pocket

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Aguemon, Badirou, Barikissou Georgia Damien, Antoine Vickey Hinson, et al. "Malaria Case-Management in Urban Area: Various Challenges in Public and Private Health Facilities in Benin, West Africa." Open Public Health Journal 11, no. 1 (2018): 54–61. http://dx.doi.org/10.2174/1874944501811010054.

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Background:In Benin, malaria remains endemic and perennial throughout the year in most areas. During the last decade, a substantial increase was noticed in the procurement of Artemisinin-based combination therapies and malaria RDT. This study aimed to evaluate the quality of uncomplicated malaria cases-management in public and private health facilities.Methods:A cross-sectional survey was carried out in public and private health facilities in the municipality of Abomey-Calavi in southern Benin from August to September 2016. The study focused on two targets: (i) patients with uncomplicated mala

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Joste, Valentin, Laurine Maurice, Gwladys I. Bertin, et al. "Identification of Plasmodium falciparum and host factors associated with cerebral malaria: description of the protocol for a prospective, case-control study in Benin (NeuroCM)." BMJ Open 9, no. 5 (2019): e027378. http://dx.doi.org/10.1136/bmjopen-2018-027378.

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IntroductionIn 2016, an estimated 216 million cases and 445 000 deaths of malaria occurred worldwide, in 91 countries. In Benin, malaria causes 26.8% of consultation and hospitalisation motif in the general population and 20.9% in children under 5 years old.The goal of the NeuroCM project is to identify the causative factors of neuroinflammation in the context of cerebral malaria. There are currently very few systematic data from West Africa on the aetiologies and management of non-malarial non-traumatic coma in small children, and NeuroCM will help to fill this gap. We postulate that an accur

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Takyi, Abena, Verena I. Carrara, Prabin Dahal, et al. "Characterisation of populations at risk of sub-optimal dosing of artemisinin-based combination therapy in Africa." PLOS Global Public Health 3, no. 12 (2023): e0002059. http://dx.doi.org/10.1371/journal.pgph.0002059.

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Selection of resistant malaria strains occurs when parasites are exposed to inadequate antimalarial drug concentrations. The proportion of uncomplicated falciparum malaria patients at risk of being sub-optimally dosed with the current World Health Organization (WHO) recommended artemisinin-based combination therapies (ACTs) is unknown. This study aims to estimate this proportion and the excess number of treatment failures (recrudescences) associated with sub-optimal dosing in Sub-Saharan Africa. Sub-populations at risk of sub-optimal dosing include wasted children <5 years of age, patients

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Vaughan Williams, C. H., C. La Cock, G. F. J. Henry, and A. J. Ross. "Audit of failure rate of sulfadoxine/pyrimetham combined with chloroquine to treat falciparum malaria at single fourteen-day follow-up." South African Family Practice 25, no. 3 (2002): 4. http://dx.doi.org/10.4102/safp.v25i3.2062.

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Objective: To assess the failure rate of the present first line treatment regime for uncomplicated falciparum malaria of sulfadoxine/pyrimethamine combined with chloroquine.Design: A before-after study.Setting: Ndumo Clinic, Ingwavuma District, South Africa, October 2000 Study Group. 55 patients presenting to Ndumo clinic with uncomplicated malaria and malaria trophozoites visible on thin film.Main outcome measures: Trophozoite count on thick film at day 14.Results: 15 out of 37 patients who returned for follow-up still had trophozoites on thick film. Symptoms of most patients at day 0 and day

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Agarwal, Aarti, Aldiouma Guindo, Yacouba Cissoko, et al. "Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S." Blood 96, no. 7 (2000): 2358–63. http://dx.doi.org/10.1182/blood.v96.7.2358.

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Abstract The malaria hypothesis proposes a survival advantage for individuals with hemoglobin variants in areas of endemicPlasmodium falciparum malaria. Hemoglobin C (HbC) is a possible example in West Africa, where this hemoglobin has a centric distribution with high frequencies among certain populations including the Dogon ethnic group. To test whether HbC is associated with protection from malaria, we performed a case-control study in the Dogon of Bandiagara, Mali. HbC was present in 68 of 391 (17.4%) of uncomplicated malaria control cases, whereas it was detected in only 3 of 67 cases (4.5

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Agarwal, Aarti, Aldiouma Guindo, Yacouba Cissoko, et al. "Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S." Blood 96, no. 7 (2000): 2358–63. http://dx.doi.org/10.1182/blood.v96.7.2358.h8002358_2358_2363.

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The malaria hypothesis proposes a survival advantage for individuals with hemoglobin variants in areas of endemicPlasmodium falciparum malaria. Hemoglobin C (HbC) is a possible example in West Africa, where this hemoglobin has a centric distribution with high frequencies among certain populations including the Dogon ethnic group. To test whether HbC is associated with protection from malaria, we performed a case-control study in the Dogon of Bandiagara, Mali. HbC was present in 68 of 391 (17.4%) of uncomplicated malaria control cases, whereas it was detected in only 3 of 67 cases (4.5%) of sev

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Vemula, Sachin, Vidyalakshmi Katara, Unnikrishnan Bhaskaran, Sushma Adappa, and Mahabala Chakrapani. "Pretreatment elevated erythrocyte sedimentation rate and C-reactive protein as a predictor of malarial complications." Journal of Infection in Developing Countries 10, no. 12 (2016): 1332–37. http://dx.doi.org/10.3855/jidc.8053.

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Introduction: Complications of malaria can develop suddenly and unexpectedly. Although various parameters have been associated with severity of malaria, they have not been studied as predictors of these events. Many of the malarial complications are inflammatory in nature, and C-reactive protein (CRP) and elevated erythrocyte sedimentation rate (ESR) could be early markers of these complications and might precede and predict the development of complications. Methodology: A total of 122 inpatients with uncomplicated newly diagnosed malaria were studied. CRP, ESR, hemoglobin, and platelets were

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Chiwakata, Collins Batsirai, Christoph Josef Hemmer, and Manfred Dietrich. "High Levels of Inducible Nitric Oxide Synthase mRNA Are Associated with Increased Monocyte Counts in Blood and Have a Beneficial Role in Plasmodium falciparum Malaria." Infection and Immunity 68, no. 1 (2000): 394–99. http://dx.doi.org/10.1128/iai.68.1.394-399.2000.

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ABSTRACT To date, there have been conflicting reports concerning the clinical significance of nitric oxide (NO) in Plasmodium falciparum malaria. Some authors have proposed that NO contributes to the development of severe and complicated malaria, while others have argued that NO has a protective role. To investigate these apparently contradictory reports, reverse transcription-coupled PCR was used to study inducible NO synthase (iNOS) in whole-blood RNA samples from patients with severe and complicated malaria or uncomplicated malaria and from healthy donors. This work produced three principal

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Manirakiza, Alexandre, Siméon Pierre Njuimo, Alain Le Faou, Denis Malvy, and Pascal Millet. "Availability of Antimalarial Drugs and Evaluation of the Attitude and Practices for the Treatment of Uncomplicated Malaria in Bangui, Central African Republic." Journal of Tropical Medicine 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/510834.

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National malaria management policy is based upon the availability of effective and affordable antimalarial drugs. This study was undertaken to evaluate the quality of the treatment of uncomplicated malaria cases in Bangui, an area with multidrug-resistant parasites, at a time preceding implementation of a new therapeutic policy relying on the artemisinin derivative combined treatment artemether-lumefantrine. A cross-sectional study was carried out in Bangui city to assess availability of antimalarial drugs and the performances of health workers in the management of uncomplicated malaria. Avail

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Seo, Eun Bin, Lissinda H. du Plessis, and Joe M. Viljoen. "Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria." Pharmaceuticals 15, no. 2 (2022): 120. http://dx.doi.org/10.3390/ph15020120.

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Malaria affects millions of people annually, especially in third-world countries. The mainstay of treatment is oral anti-malarial drugs and vaccination. An increase in resistant strains of malaria parasites to most of the current anti-malarial drugs adds to the global burden. Moreover, existing and new anti-malarial drugs are hampered by significantly poor aqueous solubility and low permeability, resulting in low oral bioavailability and patient noncompliance. Lipid formulations are commonly used to increase solubility and efficacy and decrease toxicity. The present review discusses the findin

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Hempel, Casper, Poul Hyttel, and Jørgen AL Kurtzhals. "Endothelial Glycocalyx on Brain Endothelial Cells is Lost in Experimental Cerebral Malaria." Journal of Cerebral Blood Flow & Metabolism 34, no. 7 (2014): 1107–10. http://dx.doi.org/10.1038/jcbfm.2014.79.

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We hypothesized that the glycocalyx, which is important for endothelial integrity, is lost in severe malaria. C57BL/6 mice were infected with Plasmodium berghei ANKA, resulting in cerebral malaria, or P. chabaudi AS, resulting in uncomplicated malaria. We visualized the glycocalyx with transmission electron microscopy and measured circulating glycosaminoglycans by dot blot and ELISA. The glycocalyx was degraded in brain vasculature in cerebral and to a lesser degree uncomplicated malaria. It was affected on both intact and apoptotic endothelial cells. Circulating glycosaminoglycan levels sugge

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R., Sandeep B., M. G. Bhutto, and Suresh Babu K. P. "Study of serum cortisol levels in complicated and uncomplicated Plasmodium vivax malaria patients." International Journal of Research in Medical Sciences 9, no. 1 (2020): 254. http://dx.doi.org/10.18203/2320-6012.ijrms20205853.

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Background: Malaria results in pathological changes in various body organs, as the parasite invade and multiply in circulating red blood cells. Despite of advances in diagnostic and treatment modalities, worldwide incidences of malaria are significant. Current study was conducted to investigate serum cortisol level changes as a promising biomarker for risk prediction in malaria and to study adrenal insufficiency in malaria patients.Methods: Current investigation was a prospective observational study, conducted on complicated and uncomplicated Plasmodium vivax malaria patients. Serum cortisol l

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Rampengan, Novie H., Jane Metusala, Ronald Chandra, and Praevilia Salendu. "Artesunate-amodiaquine versus artesunatesulfadoxine- pyrimethamine for uncomplicated falciparum malaria in children." Paediatrica Indonesiana 54, no. 1 (2014): 46. http://dx.doi.org/10.14238/pi54.1.2014.46-51.

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Background Malaria is a major cause of morbidity and mortalityin children, especially in developing countries. Art emisinincombination therapy (ACT) has higher rates of parasite clearanceand inhibition of anti-malarial drugs resistance than non-ACT.Hence, we compared the efficacies of artesunate-amodiaquine(AS-AQ) versus artesunate-sulfadoxine pyrimethamine (AS-SP)combination therapies in children with uncomplicated falciparummalaria.Objective To compare the fever clearance time, parasite clearancetime, and length of hospital stay in uncomplicated falciparummalaria patients treated with AS-AQ

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Lyke, K. E., R. Burges, Y. Cissoko та ін. "Serum Levels of the Proinflammatory Cytokines Interleukin-1 Beta (IL-1β), IL-6, IL-8, IL-10, Tumor Necrosis Factor Alpha, and IL-12(p70) in Malian Children with Severe Plasmodium falciparum Malaria and Matched Uncomplicated Malaria or Healthy Controls". Infection and Immunity 72, № 10 (2004): 5630–37. http://dx.doi.org/10.1128/iai.72.10.5630-5637.2004.

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ABSTRACT Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the role of these mediators in disease pathogenesis, and the relationship between host protection and injury remains unclear. A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months to 14 years residing in Bandiagara, Mali, were matched to cases of uncomplicated malaria and healthy controls. Using modified World Health Organization criteria for defining severe malaria, we identified 100 cases of cerebral malaria (coma, seizure, and obtundation), 17 ca

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A. Ali, Elrazi, Tajeldin M. Abdalla, and Ishag Adam. "Platelet distribution width, mean platelet volume and haematological parameters in patients with uncomplicated plasmodium falciparum and P. vivax malaria." F1000Research 6 (June 12, 2017): 865. http://dx.doi.org/10.12688/f1000research.11767.1.

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Background: The association between the haematological profile (including abnormal platelets) and malaria is not completely understood. There are few published data on haematological profiles of malaria patients in areas with unstable malaria transmission. The current study was conducted to investigate if the haematological parameters, including platelet indices, were reliable predictors for microscopically-diagnosed malaria infection. Methods: A case-control study with a total of 324 participants (162 in each arm) was conducted at the out-patient clinic of New Halfa hospital during the rainy

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Nosten, Francois Henri. "Pyronaridine-artesunate for uncomplicated falciparum malaria." Lancet 375, no. 9724 (2010): 1413–14. http://dx.doi.org/10.1016/s0140-6736(10)60582-x.

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Omar, S., and D. C. Warhurst. "Treatment of uncomplicated malaria: A reply." Transactions of the Royal Society of Tropical Medicine and Hygiene 96, no. 5 (2002): 573. http://dx.doi.org/10.1016/s0035-9203(02)90448-7.

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Jegede, Ayodele S., Ikeoluwapo O. Ajayi, Frederick O. Oshiname, Catherine O. Falade, and al. et. "Qualitative assessment of rural health workers' management of malaria in sick children." MalariaWorld Journal 6, no. 7 (2015): 1–10. https://doi.org/10.5281/zenodo.10870159.

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<strong>Background.</strong> Febrile illnesses are common causes of morbidity and mortality among under-five children in sub-Saharan Africa. The recommended strategy for effective case management of uncomplicated malaria is parasitological confirmation prior to use of artemisinin-based combination therapy (ACT). There is a lack of qualitative information explaining factors, which influence malaria case management practices among health workers. This study explores the perceptions of health managers and health care providers on the case management of uncomplicated malaria am

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Samad, R., MR Rahman, EB Yunus, et al. "An open randomized controlled trial to compare the efficacy of two fixed dose combinations of artemesinin based combinations for uncomplicated falciparum malaria in Bangladesh." Bangladesh Medical Research Council Bulletin 39, no. 3 (2014): 109–15. http://dx.doi.org/10.3329/bmrcb.v39i3.20310.

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National Malaria Control Program (NMCP) of Bangladesh has introduced Artemisinin Based Combination (ACT), Coartem(R) (Artemether-Lumefantrine (AL), fixed dose combination, in the confirmed cases of uncomplicated P. falciparum malaria since 2004. Despite the reduction of mortality due to malaria, the development and spread of anti-malarial drug resistance wordwide posing a threat to the health services and will make it difficult to control malaria in Bangladesh in future. We need to have an alternative to Coartem which could be Artesunate-amodiaquine (AA) in a fixed dose combination (FDC), a ch

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Kumar, Ch Subhash, D. Prashanth, D. Sharath Kumar, and M. Harikrishna Reddy. "A study of clinical profile and outcome of malaria in adults at government general hospital, Nizamabad." Panacea Journal of Medical Sciences 12, no. 2 (2022): 380–86. http://dx.doi.org/10.18231/j.pjms.2022.072.

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What has to be stressed is the need to be cautious with such individuals and to broaden our differentials to include P. vivax as a possible cause of severe malaria. Patients who are aggressively handled and treated can have a better outcome.To study the clinical profile and outcome of malaria in adults at Government General Hospital in our local area. A Cross-sectional, observational study done in Department of general medicine in Fifty smear positive malaria patients admitted to the medical wards and intensive care units are included in the study. Study done for a period of 1 Year . Patients

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Ugwu, Angela Ogechukwu. "Relationship between Neutrophil-lymphocyte Ratio, Monocyte-Lymphocyte Ratio and Parasitaemia in Determining the Severity of Malaria Infection in Children." Trop J Med Res 22, no. 2 (2024): 23–32. https://doi.org/10.5281/zenodo.14498883.

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<strong>Abstract</strong> <strong>Background</strong>: Malaria often presents as a febrile illness which causes noticeable changes in the haematological parameters. There were inconsistencies with the report on the relationship between the haematological parameters and level of parasitaemia. <strong>Objectives</strong>: This study therefore aimed to ascertain the correlation between the level of parasites in the blood, the neutrophil-lymphocyte ratio (NLR) and the monocyte –lymphocyte ratio (MLR) as a measure of severity of malaria infection. <strong>Materials and Methods</stro

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Akinkunmi, B. F., O. O. Ogunkunle, F. O. Akinbami, and A. E. Orimadegun. "Electrocardiographic features in children with severe falciparum malaria at the University College Hospital, Ibadan." Research Journal of Health Sciences 10, no. 3 (2022): 198–206. http://dx.doi.org/10.4314/rejhs.v10i3.4.

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Introduction: The high burden of Malaria morbidity and mortality in children is due to its potential to cause multi-organ dysfunction. There is however limited information on the specific electrocardiographic features in falciparum malaria in paediatric age group.Aim: To investigate the electrocardiographic (ECG) features in children with (complicated) severe falciparum malaria (SM) and acute uncomplicated malaria (AUM) at the University College Hospital, Ibadan.Methods: This was a comparative cross-sectional study conducted among 398 children with symptomatic and confirmed Plasmodium falcipar

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A., Sivaraman, Venkataraman Surendran, R. Balasubramanian, N. Kavitha, Jain Dhiraj, and Kumhar Maniram. "Serum Cortisol Level as a Predictive Biomarker of Severity of Disease among Adult Plasmodium Vivax Patients in Northern India." International Journal of Pharmaceutical and Clinical Research 15, no. 7 (2023): 1195–201. https://doi.org/10.5281/zenodo.11857003.

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<strong>Background: </strong>Malaria is a major cause of morbidity in Indian subcontinent accounting for approximately 88% of malaria cases in the Southeast Asia. The disease affects all organs and endocrine glands are no exception. Serum cortisol, a hormone released by adrenal gland has the potential to serve as a predictive biomarker for mortality and critical illness among malaria patients. <strong>Aim:</strong> This study aimed to investigate changes in serum cortisol levels as a potential biomarker for predicting risk in P. vivax malaria. <strong>Methods:</strong>&nbsp

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Salih, Magdi M., Hatim G. Eltahir, Tajeldin M. Abdallah, et al. "Haematological parameters, haemozoin-containing leukocytes in Sudanese children with severe Plasmodium falciparum malaria." Journal of Infection in Developing Countries 12, no. 04 (2018): 273–78. http://dx.doi.org/10.3855/jidc.9906.

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Introduction: Haemozoin –containing leucocytes (HCL) can be used to predict severe malaria. Methodology: A case –control study was conducted in Singa, Sudan, to investigate the haematological values and HCL in children with severe Plasmodium falciparum malaria. The cases were children with severe P. falciparum malaria (67). The two groups of controls were patients with uncomplicated P. falciparum malaria (63) and healthy children (50). Results: The mean (±SD) age was 5.5 (±3.8) years. In comparison with children with uncomplicated P. falciparum malaria, children with severe P. falc

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