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Journal articles on the topic 'Undifferentiated connective tissue disease (UCTD)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Mosca, M., C. Tani, C. Neri, C. Baldini, and S. Bombardieri. "Undifferentiated connective tissue diseases (UCTD)." Autoimmunity Reviews 6, no. 1 (2006): 1–4. http://dx.doi.org/10.1016/j.autrev.2006.03.004.

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Bodolay, Edit, and Gyula Szegedi. "Undifferentiated connective tissue disease." Orvosi Hetilap 150, no. 19 (2009): 867–72. http://dx.doi.org/10.1556/oh.2009.28610.

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Evolution of immunopathological diseases is usually slow and progressive. Non-differentiated collagen disease (NDC) or the term “undifferentiated connective tissue disease” (UCTD) represents a stage of disease where clinical symptoms and serological abnormalities suggest autoimmune disease, but they are not sufficient to fulfill the diagnostic criteria of any well-established connective tissue disease (CTD) such as systemic lupus erythematosus (SLE), Sjögren’s syndrome, mixed connective tissue disease (MCTD), systemic sclerosis (SSc), polymyositis/ dermatomyositis (PM/DM) or rheumatoid arthrit

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Farhey, Yolanda, and Evelyn Hess. "Mixed Connective Tissue Disease (MCTD) and Undifferentiated Connective Tissue Disease (UCTD)." Current Rheumatology Reviews 2, no. 3 (2006): 261–67. http://dx.doi.org/10.2174/157339706778019610.

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Siegel, C., B. Stamm, J. Vega, et al. "AB0556 CHARACTERISTICS OF PATIENTS DIAGNOSED WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1405.1–1405. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4656.

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BackgroundPatients with undifferentiated connective tissue disease (UCTD) struggle with physical symptoms as well as diagnostic uncertainty.1 UCTD diagnosis requires exclusion of other connective tissue diseases (CTD). Prior studies use variable definitions of UCTD that do not account for updated classification criteria thus limiting generalizability.ObjectivesWe identified characteristics associated with rheumatologist-diagnosed UCTD, applied strict exclusion criteria, and compared UCTD patients to those with criteria-defined CTD.MethodsWe recruited patients ≥18 years old seen between 2018-20

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De Angelis, Rossella, Angela Cerioni, Patrizia Del Medico, and Patrizia Blasetti. "Raynaud’s phenomenon in undifferentiated connective tissue disease (UCTD)." Clinical Rheumatology 24, no. 2 (2004): 145–51. http://dx.doi.org/10.1007/s10067-004-0988-2.

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Lambova, Sevdalina, Nikolay Stoilov, and Vladimira Boyadzhieva. "Capillaroscopic findings in undifferentiated connective tissue disease with Raynaud’s phenomenon." Rheumatology (Bulgaria) 31, no. 3 (2023): 44–54. http://dx.doi.org/10.35465/31.3.2023.pp44-58.

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Background: Undifferentiated connective tissue disease (UCTD) is characterized with presence of clinical signs and immunological findings suggestive of connective autoimmune disease, but the criteria for a definite rheumatic disease are not fulfilled. Raynaud’s phenomenon (RP) could be found in approximately 50% of cases with UCTD and about half of patients with UCTD and RP exhibit “scleroderma-like” pattern. The aim of the study: To assess the characteristics of capillaroscopic changes in early UCTD. Patients and methods: Inclusion criterion for the study was newly diagnosed by rh

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Antunes, Margarida, Carlo Alberto Scirè, Rosaria Talarico, et al. "Undifferentiated connective tissue disease: state of the art on clinical practice guidelines." RMD Open 4, Suppl 1 (2019): e000786. http://dx.doi.org/10.1136/rmdopen-2018-000786.

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The term ‘undifferentiated connective tissue disease’ (UCTD) is generally used to describe clinical entities characterised by clinical and serological manifestations of systemic autoimmune diseases but not fulfilling the criteria for defined connective tissue diseases (CTDs). In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the ERN ReCONNET project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations.No specific CPG on UCTD were found, potential areas of intervention are absence of a consensus

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Pan, Lin, Yuan Liu, Rongfei Sun, Mingyu Fan, and Guixiu Shi. "Comparison of Characteristics of Connective Tissue Disease-Associated Interstitial Lung Diseases, Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Diseases, and Idiopathic Pulmonary Fibrosis in Chinese Han Population: A Retrospective Study." Clinical and Developmental Immunology 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/121578.

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Our study compared the prevalence and characteristics of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), undifferentiated connective tissue disease-associated interstitial lung disease (UCTD-ILD), or idiopathic pulmonary fibrosis (IPF) between January 2009 and December 2012 in West China Hospital, western China. Patients who met the criteria for ILD were included and were assigned to CTD-ILD, UCTD-ILD, or IPF group when they met the criteria for CTD, UCTD, or IPF, respectively. Clinical characteristics, laboratory tests, and high-resolution CT images wer

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Lambova, S. "AB1385 CHARACTERISTICS OF MICROANGIOPATHY IN THE NAILFOLD AREA IN UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1797.2–1797. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5307.

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BackgroundUndifferentiated connective tissue disease (UCTD) is characterized with presence of clinical signs and immunological findings suggestive of connective autoimmune disease, but the criteria for a definite rheumatic disease are not fulfilled. Duration of symptoms below 3 years defines UCTD as “early” pathological condition (1) that requires follow-up for assessment of possible disease progression. Raynaud’s phenomenon could be found in approximately 50% of cases with UCTD and about half of patients with RP and UCTD exhibit “scleroderma-like” pattern.ObjectivesTo assess the characteristi

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Siegel, C., E. Sevim, B. Stamm, et al. "POS0715 QUANTIFYING THE PSYCHOSOCIAL IMPACT OF UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE (UCTD)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 607.1–607. http://dx.doi.org/10.1136/annrheumdis-2021-eular.929.

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Background:Only half of patients diagnosed with SLE fulfill classification criteria; the rest have “SLE-like” illnesses such as UCTD. SLE patients are known to experience impaired health-related quality of life (HRQoL) and significant anxiety, depression, and fatigue,1 yet the psychosocial aspects of UCTD are less established. In a qualitative study, we found that most UCTD patients had engaged in psychotherapy and felt additional support was needed.2Objectives:Using multiple validated instruments, this study aims to quantify the psychosocial impact of UCTD.Methods:The Hospital for Special Sur

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Cherkasov, N. S., T. N. Doronina, A. V. Prakhov, and Yu A. Lutsenko. "Clinical prognostic relevance of elastin and laminin in children with undifferentiated connective tissue disease." Russian Journal of Woman and Child Health 4, no. 4 (2021): 351–54. http://dx.doi.org/10.32364/2618-8430-2021-4-4-351-354.

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Aim: to determine clinical prognostic relevance of elastin and laminin in children with undifferentiated connective tissue disease (UCTD). Patients and Methods: 47 children with UCTD aged 3–6 were enrolled. The diagnosis was verified by ruling out genetic disorders via analyzing family tree, genetic consultation, etc. Phenotypic and visceral signs were interpreted based on "Congenital and multifactorial connective tissue diseases in children" guidelines (2016). The results of cardiovascular and urinary tract ultrasound were analyzed. Serum levels of elastin and laminin were measured by the san

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Timerbulatov, M. V., T. M. Murasov, and A. M. Murasov. "Surgical Specifics of Lower Limb Superficial Thrombophlebitis Combined with Undifferentiated Connective Tissue Disease." Creative surgery and oncology 12, no. 2 (2022): 112–17. http://dx.doi.org/10.24060/2076-3093-2022-12-2-112-117.

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Background. Superficial thrombophlebitis of lower extremities is among the most frequent acute vascular pathologies. Concomitant undifferentiated connective tissue dysplasia exerts specific changes in its clinical course.Aim: A study of the specific dynamics of acute lower limb superficial thrombophlebitis (ST) and its surgical treatment in patients with undifferentiated connective tissue dysplasia (UCTD).Materials and methods. The case histories, surgery reports and follow-up examinations of patients treated at the Vascular Surgery Unit during 2012–2020 were analysed. A total of 86 patients h

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Pizzorni, C., G. Ferrari, C. Schenone, et al. "POS0862 NAILFOLD CAPILLAROSCOPY IN UNDIFFERENTIATED AND MIXED CONNECTIVE TISSUE DISEASES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 686. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2562.

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Background:Microvascular damage is a frequent feature in connective tissue diseases (CTDs) and can be easily detected trough nailfold videocapillaroscopy (NVC) (1,2). Mixed and Undifferentiated connective tissue diseases (MCTD and UCTD) do not show a specific and unique NVC pattern (3). However, a variety of microvascular abnormalities can occur in these two CTDs, both non-specific or specific for the scleroderma like-pattern (3-5).Objectives:To retrospectively assess and compare nailfold microangiopathy observed by NVC in MCTD and stable UCTD versus primary Raynaud’s phenomenon (PRP) (6). In

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Valim, Valéria, Roberta Hora Rocha, Roberta Barcelos Couto, Thaysa Simões Paixão, and Érica Vieira Serrano. "Acute Fibrinous and Organizing Pneumonia and Undifferentiated Connective Tissue Disease: A Case Report." Case Reports in Rheumatology 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/549298.

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Acute fibrinous and organizing pneumonia (AFOP), recently described, is a histologic pattern characterized by the presence of fibrin “balls” within alveolar spaces. The term undifferentiated connective tissue disease (UCTD) is used to identify autoimmune systemic diseases that do not fulfill the criteria to be classified as a definitive connective tissue disease. The AFOP has never been reported in association with UCTD. The present reported case is a 39-year-old Caucasian, female with dry cough and progressive dyspnea. Eight months later, she was diagnosed with “organizing pneumonia” based on

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Cherkasov, Nikolay, and Yuliya Lutsenko. "CLINICAL SIGNIFICANCE OF LAMININ AND ELASTINE LEVELS IN CHILDREN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE." Archiv Euromedica 11, no. 2 (2021): 78–79. http://dx.doi.org/10.35630/2199-885x/2021/11/2/p.1.

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This research aims to study levels of laminin and elastine in 64 children with undifferentiated connective tissue disease (UCTD). All the children underwent clinical, laboratory and instrumental examination. It was found that changes in the levels of laminin and elastin are directly related to the severity of UCTD in children. Thus, clinical values of laminin and elastin levels can serve as additional criteria of UCTD severity. Using them, along with early detection of the phenotypic and visceral signs, helps prevent the development of severe forms of the disease.

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Mosca, Marta, Chiara Tani, Rosaria Talarico, and Stefano Bombardieri. "Undifferentiated connective tissue diseases (UCTD): Simplified systemic autoimmune diseases." Autoimmunity Reviews 10, no. 5 (2011): 256–58. http://dx.doi.org/10.1016/j.autrev.2010.09.013.

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Shambatov, A. M., N. V. Izmozherova, A. A. Popov, and I. F. Grishina. "Diastolic dysfunction in late postmenopausal patients with undifferentiated connective tissue disease and hypertension." Russian Journal of Cardiology 28, no. 1 (2022): 5151. http://dx.doi.org/10.15829/1560-4071-2023-5151.

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Aim. To assess myocardial diastolic function (DF) in late postmenopausal women with undifferentiated connective tissue disease (UCTD) and hypertension (HTN).Material and methods. This cross-sectional study included 135 postmenopausal women, the median age of which was 68 years (65÷70,5 years). The anamnesis was collected using a standardized questionnaire. Verification of UCTD was carried out according to clinical guidelines. All patients underwent standard transthoracic echocardiography. The assessment of left ventricular (LV) DF was carried out according to the transmitral flow. LV diastolic

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Zucchi, Dina, Chiara Tani, Francesca Monacci, et al. "Pregnancy and undifferentiated connective tissue disease: outcome and risk of flare in 100 pregnancies." Rheumatology 59, no. 6 (2019): 1335–39. http://dx.doi.org/10.1093/rheumatology/kez440.

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Abstract Objective UCTD is a systemic autoimmune condition that fails to fulfil the criteria for a definite CTD. Given that there are a lack of studies on links between pregnancy and UCTD, the purpose of this study was to evaluate the risk of disease flares or development of CTD in addition to the risk of adverse pregnancy outcomes in patients with UCTD. Methods This is a retrospective study using prospectively collected data for 100 pregnancies in 81 incidences of UCTD treated in a single referral centre. Results A total of 11 pregnancies (11%) ended in miscarriage in the first trimester and

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Murphy, Noreen, Trina Hollatz, and Keith Meyer. "Idiopathic Pleuroparenchymal Fibroelastosis (IPPFE) Associated With Undifferentiated Connective Tissue Disease (UCTD)." Chest 142, no. 4 (2012): 472A. http://dx.doi.org/10.1378/chest.1388581.

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Loginova, E. N., G. I. Nechaeva, A. N. Dakuko, I. V. Bogatyrev, V. V. Potapov, and I. V. Sharun. "Left ventricular longitudinal strain in patients with undifferentiated connective tissue disease and arrhythmia." Russian Journal of Cardiology 28, no. 12 (2023): 5665. http://dx.doi.org/10.15829/1560-4071-2023-5665.

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Aim. To evaluate the left ventricular longitudinal strain in patients with arrhythmia and undifferentiated connective tissue disease (UCTD).Material and methods. This cross-sectional comparative study included young patients with arrhythmia and UCTD (43 men and 84 women; mean age, 30,82±8,17 years (group 1, n=127)). The control group included volunteers with single phenotypic characteristics of UCTD, comparable in age and sex (9 men and 21 women, mean age, 34,13±6,87 years (group 2, n=30)). A standard clinical examination, 72-hour electrocardiographic monitoring, and speckle-tracking echocardi

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SMETANIN, M. YU, and E. N. LOGINOVA. "Dysplastic heart. Left ventricular myocardial deformation in undifferentiated connective tissue dysplasia." Practical medicine 20, no. 5 (2022): 13–18. http://dx.doi.org/10.32000/2072-1757-2022-5-13-18.

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Cardiac syndromes occupy a special place among the manifestations of undifferentiated connective tissue dysplasia (UCTD), since it is the severity of dysplastic stigmatization of the cardiovascular system (CVS) that determines the individual life and work prognosis in people with UCTD. Predicting adverse cardiovascular events is relevant, in particular, for young women with UCTD, since protecting the health of such patients in a critical demographic situation in the country (low birth rate and high mortality) is one of the most important tasks of modern medicine. Ultrasound estimation of myoca

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Radin, Massimo, Karen Schreiber, Irene Cecchi, et al. "A multicentre study of 244 pregnancies in undifferentiated connective tissue disease: maternal/fetal outcomes and disease evolution." Rheumatology 59, no. 9 (2020): 2412–18. http://dx.doi.org/10.1093/rheumatology/kez620.

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Abstract Objectives To investigate fetal/perinatal and maternal outcomes from a large multicentre cohort of women diagnosed with UCTD. Methods This multicentre retrospective cohort study describes the outcomes of 224 pregnancies in 133 consecutive women with a diagnosis of UCTD, positive for ANA and aged &lt;45 years old at study inclusion. Results Of the 224 pregnancies analysed, 177 (79%) resulted in live births, 45 (20.1%) in miscarriages (defined as pregnancy loss before 12 weeks’ gestation), 2 (0.9%) in stillbirths (pregnancy loss after 20 weeks’ gestation) and 6 (2.7%) cases showed i

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Sape., Vandana Sasi Kiran, Radha Nimmakayala, and Sindhura K. "Patterns of HRCT in Connective Tissue Disorders." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 1023–25. https://doi.org/10.5281/zenodo.12738869.

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Interstitial lung diseases (ILDs) are challenging to diagnose with traditional chest radiographs due to their low resolution and overlapping anatomical features. High-resolution computed tomography (HRCT) has transformed the diagnosis and characterization of ILDs. This study uses HRCT to evaluate pulmonary involvement in connective tissue diseases (CTDs) such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis, scleroderma, polymyositis, dermatomyositis, mixed connective tissue disease (MCTD), and undifferentiated connective tissue disease (UCTD). Significant p

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Mosca, Marta, Chiara Tani, and Stefano Bombardieri. "Undifferentiated connective tissue diseases (UCTD): a new frontier for rheumatology." Best Practice & Research Clinical Rheumatology 21, no. 6 (2007): 1011–23. http://dx.doi.org/10.1016/j.berh.2007.09.004.

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Alonso-Larruga, Ana, Sagrario Bustabad, José Antonio Navarro-Gonzálvez, Beatriz Rodríguez-Lozano, Andrés Franco, and Yvelise Barrios. "Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases." International Journal of Rheumatology 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/3076017.

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The term undifferentiated connective tissue disease (UCTD) is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis). It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Immunological and clinical r

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Il’ina, I. Yu, and A. A. Chikisheva. "Course of the pregnancy in women with connective tissue disorders." Russian Journal of Woman and Child Health 3, no. 3 (2020): 182–88. http://dx.doi.org/10.32364/2618-8430-2020-3-3-182-188.

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This paper discusses connective tissue disorders (CTD), in particular, undifferentiated connective tissue disease (UCTD) whose importance is accounted for by a high prevalence of this condition. Generalized connective tissue damage that involves reproductive system significantly affects the course of pregnancy and delivery. The complications of pregnancy, delivery, and postpartum period in women with UCTD which often require surgical procedures (i.e., amniotomy, episiotomy, perineotomy, C-section etc.) are described. The paper highlights the role of magnesium which is of crucial importance for

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Lacey, J. V., D. H. Garabrant, T. J. Laing, et al. "Petroleum Distillate Solvents as Risk Factors for Undifferentiated Connective Tissue Disease (UCTD)." American Journal of Epidemiology 149, no. 8 (1999): 761–70. http://dx.doi.org/10.1093/oxfordjournals.aje.a009885.

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Maslennikov, А. V., А. G. Yashchuk, G. Kh Gazizova, and E. F. Berdigulova. "Effectiveness of using heparinoids in patients with endometrial dysfunction and concomitant undifferentiated connective tissue disease." Voprosy ginekologii, akušerstva i perinatologii 19, no. 4 (2020): 50–56. http://dx.doi.org/10.20953/1726-1678-2020-4-50-56.

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Objective. To study the effectiveness of heparinoid sulodexide in complex therapy of patients with endometrial dysfunction and concomitant undifferentiated connective tissue disease (UCTD). Patients and methods. We examined 88 patients with UCTD and endometrial dysfunction (the «thin endometrium» phenomenon). The therapeutic regimen of 41 patients (group 1а) additionally to cyclical therapy with 17-b estradiol and didrogesterone was supplemented by continuous heparinoid sulodexide for 3 menstrual cycles (MC), 20 patients (group 1b) in addition to cyclical therapy received the heparinoid from t

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Nokhsorova, M. A., N. V. Borisova, and A. M. Ammosova. "CONNECTIVE TISSUE DISORDERS AND METABOLIC CHANGES IN CHILDREN LIVING IN THE REPUBLIC OF SAKHA (YAKUTIA)." Vestnik of North-Eastern Federal University. Medical Sciences, no. 4 (January 9, 2025): 88–98. https://doi.org/10.25587/2587-5590-2024-4-88-98.

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The article presents the results of the amino acid composition of urine in children with connective tissue disorders (undifferentiated connective tissue dysplasia syndrome – uCTD) living in the Republic of Sakha (Yakutia). Connective tissue disorders are associated with complex metabolic changes, including amino acid metabolism in children. However, currently available data are contradictory. The aim of this study was a comprehensive assessment of connective tissue disorders, as well as a comparative analysis of the amino acid levels in the urine of healthy children and children with uCTD. Mat

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Cere, A., E. Hysa, A. Lercara, et al. "AB1564 PERIPHERAL BLOOD PERFUSION IN MCTD AND UCTD PATIENTS: A CROSS-SECTIONAL MONOCENTRIC STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 2015.1–2015. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5596.

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BackgroundConnective tissue diseases (CTDs) are a heterogeneous group of autoimmune disorders and, among them, mixed connective tissue disease (MCTD) and undifferentiated connective tissue disease (UCTD) show overlap symptoms with other CTDs, but share secondary Raynaud’s Phenomenon (sRP) as a typical vascular symptom[1,2].Laser speckle contrast analysis (LASCA) is a reliable tool to measure the peripheral blood perfusion (PBP) and has already demonstrated to be useful in detecting the peripheral microcirculation status of SSc patients and severe sRP[3].ObjectivesTo measure hand PBP in patient

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Шаповалова, Д. А., А. В. Тюрин, and Р. И. Хусаинова. "Study of genetic predisposition to osteoarthritis in women with connective tissue dysplasia from the Republic of Bashkortostan." Nauchno-prakticheskii zhurnal «Medicinskaia genetika», no. 8(217) (August 31, 2020): 67–69. http://dx.doi.org/10.25557/2073-7998.2020.08.67-69.

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Остеоартрит (ОА) - наиболее распространенное многофакторное заболевание суставов. Одним из вероятных факторов риска развития ОА является недифференцированная дисплазия соединительной ткани (нДСТ) - генетически детерминированное нарушение структуры соединительной ткани, в том числе и в суставах. Вопрос о коморбидности ОА с нДСТ чрезвычайно актуален, и решение данной задачи будет способствовать разработке подходов ранней диагностики ОА в целях профилактики заболевания. Osteoarthritis (OA) is a common multifactorial joint disease. Undifferentiated connective tissue dysplasia (uCTD) is a genetical

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Chumak, O. Yu, and A. P. Volokha. "Pathological conditions in newborns against the background of undifferentiated connective tissue dysplasia in their mothers." Modern pediatrics. Ukraine, no. 6(118) (October 29, 2021): 25–31. http://dx.doi.org/10.15574/sp.2021.118.25.

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Undifferentiated connective tissue dysplasia (UCTD) in pregnant women reduces the adaptive capacity of their newborns and is an unfavorable background for the development of certain pathological conditions of the perinatal period. At the same time, information on the spectrum of diseases in children born to mothers with clinical manifestations of UCTD is rather contradictory. Purpose — to study the nature and direction of the correlation between certain pathological conditions in newborns and clinical signs of UCTD in their mothers. Materials and methods. We examined 75 women in labor aged 16

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Valiev, K. R., I. Kh Vildanov, R. R. Zyatdinov, and I. R. Gainullin. "Results of osteopathic correction in children and adolescents with undifferentiated connective tissue dysplasia." Russian Osteopathic Journal, no. 1 (March 24, 2022): 49–59. http://dx.doi.org/10.32885/2220-0975-2022-1-49-59.

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Introduction. The syndrome of undifferentiated connective tissue dysplasia (UCTD) combines a group of diseases that is heterogeneous in origin and polymorphic in clinical manifestations. UCTD is characterized by joint hypermobility and pain in the joints and back. In the last decade, osteopathic methods for the diagnosis and correction of dorsalgia and joint mobility disorders, including UCTD, have become widespread. However, the results of osteopathic correction in children and adolescents with undifferentiated dysplasia have not yet been fully investigated.The aim of the study was to researc

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Loginova, E. N., G. I. Nechaeva, A. N. Dakuko, et al. "Assessment of N-terminal pro-brain natriuretic peptide in patients with arrhythmia due to undifferentiated connective tissue disease." Russian Journal of Cardiology 28, no. 11 (2023): 5641. http://dx.doi.org/10.15829/1560-4071-2023-5641.

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Aim. To study the relationship between the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) and myocardial abnormalities in patients with cardiac arrhythmias due to undifferentiated connective tissue disease (UCTD).Material and methods. This cross-sectional comparative study included young and middle-aged patients with arrhythmias due to UCTD: group 1 (18-44 years old, n=127), group 3 (45-59 years old, n=10). The control groups (n=30, group 2; n=8, group 4) included volunteers with single phenotypic signs of UCTD, comparable in age and sex. A standard clinical examination, 72-hour

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Khovaeva, Ya B., A. L. Korovin, Ya A. Sychugov, L. V. Ermachkova, and N. P. Moiseenko. "Spontaneous coronary artery dissection as a marker of undifferentiated connective tissue dysplasia: a case report." Cardiovascular Therapy and Prevention 20, no. 7 (2021): 2973. http://dx.doi.org/10.15829/1728-8800-2021-2973.

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The article presents a case report of spontaneous coronary artery dissection (SCAD) in the young woman with signs of undifferentiated connective tissue dysplasia (UCTD). The patient was admitted urgently with a clinical and electrocardiographic signs of acute ST-segment elevation coronary syndrome. The patient underwent a coronary angiography, which revealed a type D linear intimal dissection. The decision was made to perform balloon vasodilation with the placement of a drug-eluting stent. With multicomponent therapy, the patient’s condition improved. Physical examination revealed external mar

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Torshin, I. Yu, O. A. Gromova, G. I. Nechaeva, I. A. Reier, and N. V. Zagorodniy. "Systematic analysis of molecular biological mechanisms for supporting connective tissue metabolism with chondroitin sulfate." Neurology, Neuropsychiatry, Psychosomatics 13, no. 1 (2021): 154–62. http://dx.doi.org/10.14412/2074-2711-2021-1-154-162.

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Objective: to analyze the roles of undifferentiated connective tissue dysplasia (UCTD) in the development of cartilage and ligamentous apparatus diseases.Material and methods. This paper presents the results of analyzing the literature on fundamental and clinical studies of relationships between chondroitin sulfate (CS) and connective tissue (CT) disease. A total of 922 publications on the relationship between CT dysplasia and CS and 2249 publications on CS receptor molecules were analyzed. These arrays of publications were analyzed using topological and metric approaches to data analysis.Resu

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Mineev, V. N., and L. I. Mamadayeva. "Stigmas of dysembryogenesis of undifferentiated connective tissue dysplasia in bronchial asthma." New St. Petersburg Medical Records, no. 2 (November 1, 2024): 51–56. http://dx.doi.org/10.24884/1609-2201-2024-103-2-51-56.

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Connective tissue dysplasia is a disturbance of its development during embryogenesis and the postnatal period due to genetically altered fibrillogenesis of the extracellular matrix. Undifferentiated connective tissue dysplasia (UCTD) includes a set of phenotypic characteristics that do not fit into any already known dysplastic syndrome or phenotype. It is this pathology of connective tissue that is widespread and is constantly encountered in the practice of doctors of various profiles, serving as the basis for the formation of various chronic diseases. As for bronchial asthma (BA), it is quite

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Azizova, Z. K., P. E. Eremenkova, Yu V. Chernenkov, and O. I. Gumeniuk. "Damage to the digestive tract and connective tissue dysplasia." Experimental and Clinical Gastroenterology, no. 1 (January 17, 2025): 91–95. https://doi.org/10.31146/1682-8658-ecg-233-1-91-95.

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Introduction. Connective tissue (CT) forms the structural and functional basis of all organ systems in the human body, including the gastrointestinal (GI) tract. Congenital CT disorders, commonly referred to as connective tissue dysplasia (CTD), result from mutations in genes encoding extracellular matrix proteins. CTD includes both differentiated forms, such as Marfan syndrome and Ehlers-Danlos syndrome, and undifferentiated CTD (UCTD), which lacks a specific clinical pattern. UCTD is highly prevalent, affecting up to 20% of the population, and is associated with GI disorders in more than 69%

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Urinova, Ruzagul Shaxobiddin kizi. "Analysis of the structure of early genital prolapse in women of reproductive age and identification of risk factors for their development." Journal of reproductive health and uronephrology research 4, no. 4 (2023): 3. https://doi.org/10.5281/zenodo.8327827.

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Genital prolapse (PG) accounts for about 28-39% in rare gynecological diseases. The problem is exacerbated by the fact that about 1/3 of all pregnant women are of reproductive age. The key link in the pathogenesis of genital prolapse in women of reproductive age is undifferentiated connective tissue dyplasia (UCTD). We conducted in 116 women with PH, which were analyzed with the position or position of their UCTD. The development of early PH in women of reproductive age was significantly influenced by a history of 2 or more births (51.7%), trauma during childbirth (12.3%), rapid / rapid birth

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Rymarchuk, M. І., A. R. Cheredarchuk, and Okoloch Onieca Gibson. "On the issue of pathogenesis of placental dysfunction in women with miscarriage." HEALTH OF WOMAN, no. 2(138) (March 30, 2019): 46–48. http://dx.doi.org/10.15574/hw.2019.138.46.

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To determine the correlation of local non-progressive abruption of placenta and the development of placental dysfunction with undifferentiated connective tissue dysplasia (UCTD), we have conducted the case-consequence research with 100 patients. The research included two stages. At the first stage, all the predictors of this complication were divided into 4 groups: somatic anamnesis, obstetric, gynecological and infectious anamnesis, course of the given pregnancy and results of tests for Phase-II detoxification gene polymorphism. At the second stage, all the significant predictors were include

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Sertakova, A. V., M. Ch Timaev, S. A. Rubashkin, M. M. Dokhov, and K. P. Zvereva. "CLINICAL AND DIAGNOSTICS CRITERIA OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN CHILDREN WITH DEVELOPMENTAL DYSPLASIA OF THE HIP." Pediatria. Journal named after G.N. Speransky 100, no. 5 (2021): 69–75. http://dx.doi.org/10.24110/0031-403x-2021-100-5-69-75.

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Developmental dysplasia of the hip (DDH) is characterized by varying degrees of underdevelopment of the hip joint (HJ) and para-articular tissues with numerous variants of clinical and anatomical criteria. It is now considered one of the manifestations of undifferentiated connective tissue dysplasia (UCTD), which is confirmed by genetic testing. Undoubtedly, children with DDH also have other manifestations of UCTD, the clinical combination of which must be taken into account for the overall prognosis of the patient's quality of life, as well as the determination of control points in the treatm

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Santiago, T., M. Luis, J. Lima, C. Gaspar, M. J. Salvador, and J. A. P. Da Silva. "POS0878 ULTRASOUND ASSESSMENT OF DERMAL THICKNESS AND SKIN STIFFNESS IN UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE AT RISK FOR SYSTEMIC SCLEROSIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 695–96. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3384.

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Background:High-frequency ultrasound (HFUS) and shear-wave elastography (SWE) allow an objective assessment of skin involvement in systemic sclerosis (SSc) patients.1 Till now it has been applied to patients with established diagnosis.2,3 However, there is no data concerning its application in Undifferentiated Connective Tissue Disease at risk for SSc (UCTD-risk-SSc), i.e., patients with Raynaud’s phenomenon and either SSc marker autoantibodies or typical capillaroscopic findings or both, not satisfying classification criteria for SSc.4Objectives:To compare ultrasound-dermal thickness (DT) and

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Romash, Iryna B., and Vasyl G. Mishchuk. "THE FREQUENCY OF VISCERAL AND PHENOTYPIC MARKERS IN PATIENTS WITH THE COMBINATION OF UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE AND GASTROESOPHAGEAL REFLUX DISEASE." Wiadomości Lekarskie 73, no. 7 (2020): 1492–98. http://dx.doi.org/10.36740/wlek202007134.

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The aim: The aim of the research was to study the prevalence of visceral and phenotypic markers of UCTD syndrome in patients with GERD for the purpose of early diagnosis of this comorbidity. Materials and methods: The study included 120 patients: 75 patients (Group II) – GERD was on the background of UCTD, 45 (Group I ) – the patients with GERD. The average age of the patients was 42.05 ± 6.5 years. Evaluations of UCTD’s were performed accordingly to the criteria recommended by M. Moska et al., A. Doria et al., T. I. Kadurina, L. M. Abbakumova in the modification of T. Milkovskaya-Dimitrova, a

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Elefante, E., A. Parma, V. Nannipieri, et al. "POS0789 APPLICATION OF THE NEW ACR/EULAR 2019 CLASSIFICATION CRITERIA OF SYSTEMIC LUPUS ERYTHEMATOSUS TO A INCEPTION, MONOCENTRIC COHORT OF UNDIFFERENTIATED CONNECTIVE TISSUE DISEASES POPULATION AT ONSET OF THE DISEASE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 647.1–647. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3909.

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Background:undifferentiated connective tissue diseases (UCTDs) are a group of systemic autoimmune diseases that share clinical and serological manifestations with definite connective tissue diseases (CTDs), but do not satisfy existing classification criteria1. Within this group, it is possible to identify very heterogeneous conditions: transitory and self-limiting forms, stable conditions over time and forms that will evolve towards definite CTDs, in particular Systemic Lupus Erythematosus (SLE). The availability of new classification criteria for CTDs could be useful in identifying major CTDs

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Dr., Avinash Buche, Gauri Dank Dr., Vaishali Khadke Dr., and Sandhya Bhattad Dr. "Pregnancy Outcomes in Autoimmune Diseases." International Journal of Innovative Science and Research Technology 7, no. 7 (2022): 1289–92. https://doi.org/10.5281/zenodo.6997148.

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Autoimmune diseases are common in reproductive age group. Pregnancy is known to alter the disease course in many patients with autoimmune diseases.The aim of this study is to assess the impact of autoimmune connective tissue disorders and its treatment on the outcomes of pregnancy. Methods: 15 antenatal patients with autoimmune connective tissue diseases, comprising of Systemic Lupus Erythematosus (SLE), antiphospholipid antibody syndrome (APS), Undifferentiated Connective Tissue Diseases (UCTD), Rheumatoid Arthritis(RA),Sjogren’s syndrome, systemic sclerosis were analyzed with respect t

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Edwards, Mitchell, Jennifer Ray, Ahmad Al-Taee, and Elizabeth Marsicano. "Systemic Sclerosis Sine Scleroderma as a Rare Etiology of Chronic Intestinal Pseudo-Obstruction." Canadian Journal of General Internal Medicine 16, no. 3 (2021): e74-e77. http://dx.doi.org/10.22374/cjgim.v16i3.494.

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Chronic intestinal pseudo-obstruction (CIPO) is a disruption of the enteric nervous system characterized by chronic intestinal dysmotility and dilation. It has many underlying causes. We present a 52-year-old woman with 53 kg unintentional weight loss, abdominal pain, and vomiting. She had dilated small bowel loops with air fluid levels and no transition point on CT. Esophagogastroduodenoscopy (EGD) revealed aperistalsis and undigested duodenal food. The secondary cause was found to be Undifferentiated Connective Tissue Disorder (UCTD), a rheumatologic disorder that does not meet criteria for

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Reznichenko, N. A., E. V. Zoloto, E. A. Maylyan, et al. "Serum levels of several cytokines in undifferentiated connective tissue dysplasia in adolescent girls." Astrakhan medical journal 19, no. 4 (2024): 78–84. https://doi.org/10.17021/1992-6499-2024-4-78-84.

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The problem of connective tissue dysplasia is caused by the widespread spread among the population, the progressive nature of the disease, the involvement of various organs and systems in the lesion, a sufficiently high disability of patients and a decrease in working capacity. The aim – of the study was to study the serum content of certain pro- and anti-inflammatory cytokines in adolescent girls with undifferentiated connective tissue dysplasia and menstrual cycle disorders. 245 adolescent girls aged 11 to 17 years were examined (14.0 ± 0.15 years). Among them, 176 patients assigned to the m

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Cordiali-Fei, Paola, Anna Mussi, Giovanna D'Agosto, et al. "Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease." Clinical and Developmental Immunology 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/390563.

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In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, and in patients presenting with clinical signs and symptoms of UCTD. A large panel of serum antibodies directed towards nuclear, nucleolar, and cytoplasmic antigens, including well-recognized molecules

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Malceva, Irina V., Irina I. Sheremetieva, Elena F. Kotovshchikova, Anastasia A. Selezneva, and Evgenia V. Buylova. "Role of monocytes in the development of psychovegetative disorders in young people with undifferentiated connective tissue dysplasia." Medical Journal of the Russian Federation 29, no. 1 (2023): 5–16. http://dx.doi.org/10.17816/medjrf163238.

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BACKGROUND: The immune system plays an important role in the development of neuropathology. Dysfunction of monocytes/macrophages can contribute to environmental health and the development of neuroinflammatory and neurodegenerative diseases. Two subpopulations of monocytes are distinguished, namely, anti-inflammatory and activated pro-inflammatory monocytes, producing cytokines interleukin (IL)-1, IL-6, IL-2, IL-8, and tumor necrosis factor (TNF)-, which are involved in immune inflammation in mental diseases. Violations of cellular, phagocytic, and/or humoral immunity are often found in patient

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SMETANIN, M. YU. "Parameters of the global longitudinal myocardial deformation of the left ventricle in young women with connective tissue dysplasia." Practical medicine 20, no. 5 (2022): 73–77. http://dx.doi.org/10.32000/2072-1757-2022-5-73-77.

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Diagnosis of undifferentiated connective tissue dysplasia (UCTD) is a complex and controversial problem in the clinic of internal diseases. The medical and social significance of UCTD in young women is due to the variability of symptoms and the progressive course with multiple organicity and polysystemic disease. In therapy and cardiology, attention is focused on the issues of timely diagnosis of heart failure (HF) in individuals with preserved left ventricular ejection fraction (LV EF). Expert-grade ultrasound scanners are used to identify preclinical signs of LV myocardial dysfunction and as

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