Relevant bibliographies by topics / Undifferentiated mesenchymal cells

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  2. Dissertations / Theses
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  4. Conference papers

Academic literature on the topic 'Undifferentiated mesenchymal cells'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Undifferentiated mesenchymal cells"

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Galiè, Mirco. "Mesenchymal Traits as an Intrinsic Feature of Undifferentiated Cells." Journal of Developmental Biology 13, no. 1 (2024): 1. https://doi.org/10.3390/jdb13010001.

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Since its first conceptualization over a century ago, the mesenchymal phenotype has traditionally been viewed as either a transient phase between successive epithelial stages or as a feature of cell types primarily devoted to structural support. However, recent findings in cancer research challenge this limited view, demonstrating that mesenchymal traits and hybrid mesenchymal/epithelial states can mark cancer cells with stem cell properties. By analyzing publicly available single-cell transcriptome datasets from early embryonic stages and adult tissues, this study aims to extend this concept
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Yang, Y., K. C. Palmer, N. Relan, C. Diglio, and L. Schuger. "Role of laminin polymerization at the epithelial mesenchymal interface in bronchial myogenesis." Development 125, no. 14 (1998): 2621–29. http://dx.doi.org/10.1242/dev.125.14.2621.

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Undifferentiated mesenchymal cells were isolated from mouse embryonic lungs and plated at subconfluent and confluent densities. During the first 5 hours in culture, all the cells were negative for smooth muscle markers. After 24 hours in culture, the mesenchymal cells that spread synthesized smooth muscle alpha-actin, muscle myosin, desmin and SM22 in levels comparable to those of mature smooth muscle. The cells that did not spread remained negative for smooth muscle markers. SM differentiation was independent of cell-cell contact or proliferation. In additional studies, undifferentiated lung
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Chattong, Supreecha, Ruttachuk Rungsiwiwut, Wittaya Yindeedej, et al. "Original article. Human dental pulp stem cells as a potential feeder layer for human embryonic stem cell culture." Asian Biomedicine 8, no. 3 (2014): 333–43. http://dx.doi.org/10.5372/1905-7415.0803.297.

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AbstractBackground: Human embryonic stem (hES) cells are pluripotent, and can differentiate into three germ layers. Traditionally, cultures of hES cells are maintained in a system containing mouse embryonic fibroblasts as a feeder layer for support of undifferentiated growth. However, contamination by animal cells limits the use of hES cells.Objective: We evaluated the use of human dental pulp stem cells (hDPSCs) as a feeder layer for hES cell culture. It should be possible to obtain a new source of human mesenchymal stem cells for feeder cells to maintain undifferentiated growth of hES cells.
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Yang, Y., N. K. Relan, D. A. Przywara, and L. Schuger. "Embryonic mesenchymal cells share the potential for smooth muscle differentiation: myogenesis is controlled by the cell's shape." Development 126, no. 13 (1999): 3027–33. http://dx.doi.org/10.1242/dev.126.13.3027.

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Undifferentiated embryonic mesenchymal cells are round/cuboidal in shape. During development, visceral myogenesis is shortly preceded by mesenchymal cell elongation. To determine the role of the cell's shape on smooth muscle development, undifferentiated embryonic mesenchymal cells from intestine (abundant visceral muscle), lung (some visceral muscle) or kidney (no visceral muscle) were plated under conditions that maintained cell rounding or promoted elongation. Regardless of their fate in vivo, all the cells differentiated into smooth muscle upon elongation as indicated by the expression of
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Donson, Andrew, Austin Gillen, Riemondy Kent, et al. "EPEN-31. SINGLE-CELL RNAseq OF CHILDHOOD EPENDYMOMA REVEALS DISTINCT NEOPLASTIC CELL SUBPOPULATIONS THAT IMPACT ETIOLOGY, MOLECULAR CLASSIFICATION AND OUTCOME." Neuro-Oncology 22, Supplement_3 (2020): iii314. http://dx.doi.org/10.1093/neuonc/noaa222.167.

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Abstract Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in the majority of children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development of effective therapy. We therefore used single-cell RNA sequencing to catalog cellular heterogeneity of 26 childhood EPN, predominantly from ST-RELA, PFA1 and PFA2 subgroups. ST-RELA and PFA subgroups clustered separately, with ST-RELA clustering largely according to individual sample-of-origin. PFA1 and PFA2 subgroup EPNs cells were in
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Smirnova, Yuliya D., Dominik Hanetseder, Lukas Derigo, et al. "Osteosarcoma Cells and Undifferentiated Human Mesenchymal Stromal Cells Are More Susceptible to Ferroptosis than Differentiated Human Mesenchymal Stromal Cells." Antioxidants 14, no. 2 (2025): 189. https://doi.org/10.3390/antiox14020189.

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Current research suggests that promoting ferroptosis, a non-apoptotic form of cell death, may be an effective therapy for osteosarcoma, while its inhibition could facilitate bone regeneration and prevent osteoporosis. Our objective was to investigate whether the susceptibility to and regulation of ferroptosis differ between undifferentiated (UBC) and differentiated (DBC) human bone marrow stromal cells, as well as human osteosarcoma cells (MG63). Ferroptosis was induced by either inhibiting glutathione peroxidase 4 (GPX4) using RSL3 or blocking all glutathione-dependent enzymes through inhibit
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Haffen, K., M. Kedinger, and P. Simon‐Assmann. "Mesenchyme‐Dependent Differentiation of Epithelial Progenitor Cells in the Gut." Journal of Pediatric Gastroenterology and Nutrition 6, no. 1 (1987): 14–23. http://dx.doi.org/10.1002/j.1536-4801.1987.tb09239.x.

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SummaryThe digestive tract and the gut as a paradigm represents an attractive system for the study of mechanisms involved in the differentiation of two types of progenitor cells: the endodermal cells during embryonic life and the undifferentiated crypt cells during epithelial renewal of the adult intestine. The morphological and functional events that accompany the differentiation processes of progenitor cells into the polarized epithelial cell types characteristic of the intestine appear comparable in both situations (1,2). During organogenesis of the gut, histological observations underlined
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Kanki, Keita, Ryota Watanabe, Le Nguyen Thai, Chun-Hao Zhao, and Kyoko Naito. "HDAC9 Is Preferentially Expressed in Dedifferentiated Hepatocellular Carcinoma Cells and Is Involved in an Anchorage-Independent Growth." Cancers 12, no. 10 (2020): 2734. http://dx.doi.org/10.3390/cancers12102734.

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Aberrant activation of histone deacetylases (HDACs) is one of the causes of tumor cell transformation in many types of cancer, however, the critical HDAC responsible for the malignant transformation remain unclear. To identify the HDAC related to the dedifferentiation of hepatocellular carcinoma (HCC) cells, we investigated the expression profile of HDACs in differentiated and undifferentiated hepatoma cells. We found that HDAC9, a member of the class II HDAC, is preferentially expressed in undifferentiated HCC cells. Analysis of 373 HCC patients in The Cancer Genome Atlas (TCGA) database reve
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Foudah, Dana, Marianna Monfrini, Elisabetta Donzelli, et al. "Expression of Neural Markers by Undifferentiated Mesenchymal-Like Stem Cells from Different Sources." Journal of Immunology Research 2014 (2014): 1–16. http://dx.doi.org/10.1155/2014/987678.

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The spontaneous expression of neural markers, already demonstrated in bone marrow (BM) mesenchymal stem cells (MSCs), has been considered as evidence of the MSCs’ predisposition to differentiate toward neural lineages, supporting their use in stem cell-based therapy for neural repair. In this study we have evaluated, by immunocytochemistry, immunoblotting, and flow cytometry experiments, the expression of neural markers in undifferentiated MSCs from different sources: human adipose stem cells (hASCs), human skin-derived mesenchymal stem cells (hS-MSCs), human periodontal ligament stem cells (h
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Coelho de Oliveira, Vanessa Carvalho, Danúbia Silva dos Santos, Leandro Vairo, et al. "Hair follicle-derived mesenchymal cells support undifferentiated growth of embryonic stem cells." Experimental and Therapeutic Medicine 13, no. 5 (2017): 1779–88. http://dx.doi.org/10.3892/etm.2017.4195.

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Dissertations / Theses on the topic "Undifferentiated mesenchymal cells"

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Zhou, Yinghong. "Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/63002/1/Yinghong_Zhou_Thesis.pdf.

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The body of work presented in this dissertation has demonstrated that the interactions between donor cells and host cells are critical for bone repair and regeneration. The donor cells secrete VEGF which activates the downstream PI3K/Akt signaling pathway, ultimately leading to host cell recruitment and robust bone regeneration. The findings from this dissertation may provide a scientific rationale for the development of novel therapeutic strategies in the treatment and management of bone defects.
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Antonini, Silvia. "Antioxidant Activities of Clovamide and Curcumin on Undifferentiated Cells from Different Origin." Doctoral thesis, Università del Piemonte Orientale, 2017. http://hdl.handle.net/11579/102509.

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Il trapianto di cellule staminali è uno degli approcci terapeutici maggiormente studiati. La bassa sopravvivenza, il ridotto attecchimento e la limitata capacità di migrazione rappresentano i principali limiti nel successo di questo metodo. Uno dei fattori principali che contribuiscono a questi insuccessi è lo sviluppo di stress ossidativo. Per questo motivo, il pre-trattamento ex-vivo delle cellule destinate al trapianto, al fine di aumentare l’attivazione di pathways citoprotettivi, potrebbe dimostrarsi una strategia vincente. Il cacao e la il tumerico contengono, rispettivamente, clovamide
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Chen, X. "Study of immunological properties of bone marrow-derived undifferentiated and differentiated mesenchymal stem cells." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438164.

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Vasconcelos, Rodrigo Gadelha. "A influ?ncia da criopreserva??o nas c?lulas mesenquimais indiferenciadas do ligamento periodontal de humanos an?lise comparativa in vitro." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17064.

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Made available in DSpace on 2014-12-17T15:30:56Z (GMT). No. of bitstreams: 1 RodrigoGV_DISSERT.pdf: 1378162 bytes, checksum: aa53c22bf2541e2d42d5b5659f380375 (MD5) Previous issue date: 2011-02-04<br>Cryopreservation is a process where cells or biological tissues are preserved by freezing at very low temperatures and aims to cease reversibly, in a controlled manner, all the biological functions of living tissues, i.e., maintain cell preservation so that it can recover with high degree of viability and functional integrity. This study aimed to evaluate the influence of cryopreservation on the
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Tsai, Chih-Chien, and 蔡志謙. "Oct4 and Nanog directly maintain self-renewal and undifferentiated status in mesenchymal stem cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/86603676559024247306.

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博士<br>國立陽明大學<br>藥理學研究所<br>99<br>Oct4 and Nanog are pluripotency genes, but their roles in adult stem cells are unclear. Here, increase in Oct4 and Nanog expression along with increased proliferation and differentiation potential but decreased spontaneous differentiation were observed in early passage (E), hypoxic culture (H) and p21 knockdown (p21KD) mesenchymal stem cells (MSCs) compared to late passage (L), normoxic culture (N) and scrambled shRNA-overexpressed (Scr) MSCs. Knockdown of Oct4 and Nanog in E, H and p21KD MSCs decreased proliferation and differentiation potential, and enhanced s
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Martins, Joana Maria Azevedo. "Development of a polymeric matrix based on hyaluronic acid and dextrin hydrogels for the expansion of undifferentiated mesenchymal stem cells." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/74425.

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Martins, Joana Maria Azevedo. "Development of a polymeric matrix based on hyaluronic acid and dextrin hydrogels for the expansion of undifferentiated mesenchymal stem cells." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/74425.

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Chen, po-Han, and 陳柏翰. "Comparison between the therapeutic effect of differentiated and undifferentiated human umbilical cord Wharton's jelly mesenchymal stem cells in STZ-induced diabetic rats." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/vu8z5m.

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Book chapters on the topic "Undifferentiated mesenchymal cells"

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Scuteri, Arianna. "Treatment of Neurodegenerative Pathologies Using Undifferentiated Mesenchymal Stem Cells." In Stem Cells and Cancer Stem Cells, Volume 6. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2993-3_16.

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Ruberte, Esther, Harikrishna Nakshatri, Philippe Kastner, and Pierre Chambon. "Retinoic acid receptors and binding proteins in mouse limb development." In Retinoids in Normal Development and Teratogenesis. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198547709.003.0008.

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Abstract The vertebrate limb appears as an outgrowth in the flank of the embryonic body. Initially it consists of a mesenchymal core covered by a layer of ectoderm. During the elongation of the limbs the apparently homogeneous population of the mesenchymal cells gives rise to different cell types: cartilage, bone, muscle, and other tissues, that develop in appropriate spatial relationships to constitute the developed limb. From grafting experiments that have been performed mainly in the chick, it appears that two mechanisms are involved in the formation of the proximodistal (from the base to t
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Sengenes Coralie, Maumus Marie, Jorgensen Christian, and Noël Danièle. "Adipose Stem Cells: Identification, Properties and Interest for Clinical Applications." In Biomedical and Health Research. IOS Press, 2012. https://doi.org/10.3233/978-1-61499-076-5-78.

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Adipose derived mesenchymal stromal cells or adipose stem cells (ASCs) are undifferentiated progenitor cells residing in various locations of the fat tissue in the body. The increasing interest towards these adult stem cells relies on the ease of harvest in large quantities and the robust expansion rate that make them attractive sources of cells for regenerative medicine. These cells show phenotypic, differentiation and paracrine characteristics similar to adult mesenchymal stem cells (MSCs) isolated from bone marrow. These properties are shared by culture-expanded MSCs and ASCs. However, the
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Hellemans, Jan, and Geert R. Mortier. "IHH and Acrocapitofemoral Dysplasia and Brachydactyly A1." In Inborn Errors Of Development. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0022.

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Abstract The 7rst steps in skeletal morphogenesis involve the induction of undifferentiated mesenchyme and its differentiation into condensed mesenchyme. In the human skeleton, only the membranous bones of the skull and part of the clavicle are formed by direct ossi7cation of condensed mesenchyme (intramembranous ossi7cation). For the large majority of bones, bone formation and growth proceed through an intermediate cartilaginous template or anlage in a process called endochondral ossi7cation. These cartilaginous models are formed by further differentiation of condensed mesenchymal cells into
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Bukulmez, Hulya, and Gurinder Kumar. "Clinical Use of Mesenchymal Stem Cells in Treatment of Systemic Lupus Erythematosus." In Lupus - Need to Know. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97261.

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Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune inflammatory disorder with considerable clinical heterogeneity and a prevalence of 26 to 52 out of 100,000. In autoimmune diseases, such as SLE, the immune system loses its ability to distinguish between self and other. Treatment of SLE is challenging because of clinical heterogeneity and unpredictable disease flares. Currently available treatments, such as corticosteroids, cyclophosphamide (CYC), and other immunosuppressive or immunomodulating agents, can control most lupus flares but a definitive cure is rarely achieved.
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Mesquita, Carolina, Bruna Lopes, Patrícia Sousa, et al. "Application of Cell-Based Therapies in Veterinary Dermatology." In Wound Healing - Recent Advances and Future Opportunities [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.111553.

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Stem cells have been extensively studied in the field of veterinary medicine due to their unique characteristics. The last are undifferentiated cells with self-renewal, anti-inflammatory, and immunomodulatory capacity. Mesenchymal stem cells (MSCs) are widely used due to its simple isolation and expansion, being collected from different sources such as adipose tissue, bone marrow, peripheral blood, and umbilical cord. For that reason, MSCs have been studied and used as innovative therapies in the treatment of several diseases, such as tendinitis, bone regeneration, osteoarthritis, neuromuscula
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Ture, Zeynep, Gokcen Dinc, and Emine Alp. "The Promising Treatment of Sepsis: Stem Cell Therapy." In Frontiers in Stem Cell and Regenerative Medicine Research. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815238600124110006.

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Sepsis is a life-threatening syndrome that develops as a result of a dysregulated immune response caused by an infectious agent. The pathogenesis of sepsis has been better understood over the years, and new treatment protocols have been developed. In sepsis, the host immune response is equally as important as the infectious agent in the clinical presentation of sepsis and the development of shock. In the early phase of sepsis, hyperinflammation and secondary hyperinflammation occur, while in the late phase, immunosuppression is present. Sepsis treatment is based on controlling the source of in
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Pastrello, Matheus Toledo, Edmara Pamela Izaías, Gustavo Soldá Barboza, et al. "Stem cells: concepts, applications and ethical implications." In Health of Tomorrow: Innovations and Academic Research. Seven Editora, 2024. http://dx.doi.org/10.56238/sevened2023.007-034.

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Introduction. Stem cells are undifferentiated cells or cells with a low degree of differentiation, originating from the embryo or extraembryonic tissues, which can differentiate into various types of tissues according to their plasticity, being promising in the therapy of various diseases. Objective. The objective of this study was to review the literature on the different types of stem cells, recent research on their use and current Brazilian legislation. Methodology. For this, a bibliographic survey was carried out in the VHL Health database using stem cells, legislation, biosafety, and appl
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Chong, Samuel S., Felicia S. H. Cheah, and Ethylin Wang Jabs. "Genes Implicated in Lip and Palate Development." In Cleft Lip And Palate. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780195139068.003.0003.

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Abstract Normal development of facial structures such as the lip and palate is a dynamic, highly regulated, and complex process (Francis-West et al., 1998; Schutte and Murray, 1999). Signaling interactions control the normal outgrowth of facial primordia from undifferentiated mesenchymal cells, as well as the subsequent fusion of the frontal nasal mass and the left and right maxillary primordia to form intricate facial structures such as the lip and palate. From mouse mutant models, human syndromes, and both association and expression studies, a spectrum of gene products, such as transcription
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Goodman, Frances R., and Peter J. Scambler. "HOXD13 and Synpolydactyly." In Inborn Errors Of Development. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0072.

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Abstract OXD13 (homeobox D13), the most 5” member of the HOXD gene cluster, encodes a highly conserved transcription factor that plays a crucial role in the development of the autopod; but the molecular pathway in which it acts is poorly understood. Little is known about how its expression is regulated, and none of its target genes or transcriptional cofactors has yet been identified. Synpolydactyly (SPD), the first human birth defect found to be caused by mutations in a HOX gene, is a rare, dominantly inherited malformation of the hands and feet, characterized by soft tissue syndactyly betwee
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Conference papers on the topic "Undifferentiated mesenchymal cells"

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Hackett, T., D. Stefanowicz, F. Shaheen, et al. "Epithelial-Mesenchymal Transition Occurs in Undifferentiated Basal Airway Epithelial Cells Derived from Normal and Asthmatic Subjects." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5294.

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Henkels, Julia A., and Evan A. Zamir. "A Novel Biomimetic Model for Studying Mechanics of Embryonic Morphogenesis and Differentiation." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19608.

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Before the explosion of genetics research in the last century, embryonic development was largely studied from a mechanical perspective. Paired with genetic advances in understanding developmental signaling pathways and induction mechanisms, an important goal for understanding morphogenesis is to discover how the genome codes for changes in the mechanical movements of the embryonic cells. After formation of the zygote, a phase of rapid mitotic cell division is followed by epithelialization resulting in a cohesive sheet of cells termed the epiblast. During the next major phase of triploblastic d
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Graham, Cassandra, Bekim Sadikovic, Michael Ho, et al. "Abstract 3423: Immunohistochemical expression and cluster analysis of mesenchymal and neural stem cell-associated proteins in pediatric undifferentiated soft tissue sarcomas." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3423.

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