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Journal articles on the topic 'Undifferentiated mesenchymal cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Galiè, Mirco. "Mesenchymal Traits as an Intrinsic Feature of Undifferentiated Cells." Journal of Developmental Biology 13, no. 1 (2024): 1. https://doi.org/10.3390/jdb13010001.

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Since its first conceptualization over a century ago, the mesenchymal phenotype has traditionally been viewed as either a transient phase between successive epithelial stages or as a feature of cell types primarily devoted to structural support. However, recent findings in cancer research challenge this limited view, demonstrating that mesenchymal traits and hybrid mesenchymal/epithelial states can mark cancer cells with stem cell properties. By analyzing publicly available single-cell transcriptome datasets from early embryonic stages and adult tissues, this study aims to extend this concept

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2

Yang, Y., K. C. Palmer, N. Relan, C. Diglio, and L. Schuger. "Role of laminin polymerization at the epithelial mesenchymal interface in bronchial myogenesis." Development 125, no. 14 (1998): 2621–29. http://dx.doi.org/10.1242/dev.125.14.2621.

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Undifferentiated mesenchymal cells were isolated from mouse embryonic lungs and plated at subconfluent and confluent densities. During the first 5 hours in culture, all the cells were negative for smooth muscle markers. After 24 hours in culture, the mesenchymal cells that spread synthesized smooth muscle alpha-actin, muscle myosin, desmin and SM22 in levels comparable to those of mature smooth muscle. The cells that did not spread remained negative for smooth muscle markers. SM differentiation was independent of cell-cell contact or proliferation. In additional studies, undifferentiated lung

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Chattong, Supreecha, Ruttachuk Rungsiwiwut, Wittaya Yindeedej, et al. "Original article. Human dental pulp stem cells as a potential feeder layer for human embryonic stem cell culture." Asian Biomedicine 8, no. 3 (2014): 333–43. http://dx.doi.org/10.5372/1905-7415.0803.297.

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AbstractBackground: Human embryonic stem (hES) cells are pluripotent, and can differentiate into three germ layers. Traditionally, cultures of hES cells are maintained in a system containing mouse embryonic fibroblasts as a feeder layer for support of undifferentiated growth. However, contamination by animal cells limits the use of hES cells.Objective: We evaluated the use of human dental pulp stem cells (hDPSCs) as a feeder layer for hES cell culture. It should be possible to obtain a new source of human mesenchymal stem cells for feeder cells to maintain undifferentiated growth of hES cells.

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Yang, Y., N. K. Relan, D. A. Przywara, and L. Schuger. "Embryonic mesenchymal cells share the potential for smooth muscle differentiation: myogenesis is controlled by the cell's shape." Development 126, no. 13 (1999): 3027–33. http://dx.doi.org/10.1242/dev.126.13.3027.

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Undifferentiated embryonic mesenchymal cells are round/cuboidal in shape. During development, visceral myogenesis is shortly preceded by mesenchymal cell elongation. To determine the role of the cell's shape on smooth muscle development, undifferentiated embryonic mesenchymal cells from intestine (abundant visceral muscle), lung (some visceral muscle) or kidney (no visceral muscle) were plated under conditions that maintained cell rounding or promoted elongation. Regardless of their fate in vivo, all the cells differentiated into smooth muscle upon elongation as indicated by the expression of

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5

Donson, Andrew, Austin Gillen, Riemondy Kent, et al. "EPEN-31. SINGLE-CELL RNAseq OF CHILDHOOD EPENDYMOMA REVEALS DISTINCT NEOPLASTIC CELL SUBPOPULATIONS THAT IMPACT ETIOLOGY, MOLECULAR CLASSIFICATION AND OUTCOME." Neuro-Oncology 22, Supplement_3 (2020): iii314. http://dx.doi.org/10.1093/neuonc/noaa222.167.

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Abstract Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in the majority of children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development of effective therapy. We therefore used single-cell RNA sequencing to catalog cellular heterogeneity of 26 childhood EPN, predominantly from ST-RELA, PFA1 and PFA2 subgroups. ST-RELA and PFA subgroups clustered separately, with ST-RELA clustering largely according to individual sample-of-origin. PFA1 and PFA2 subgroup EPNs cells were in

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Smirnova, Yuliya D., Dominik Hanetseder, Lukas Derigo, et al. "Osteosarcoma Cells and Undifferentiated Human Mesenchymal Stromal Cells Are More Susceptible to Ferroptosis than Differentiated Human Mesenchymal Stromal Cells." Antioxidants 14, no. 2 (2025): 189. https://doi.org/10.3390/antiox14020189.

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Current research suggests that promoting ferroptosis, a non-apoptotic form of cell death, may be an effective therapy for osteosarcoma, while its inhibition could facilitate bone regeneration and prevent osteoporosis. Our objective was to investigate whether the susceptibility to and regulation of ferroptosis differ between undifferentiated (UBC) and differentiated (DBC) human bone marrow stromal cells, as well as human osteosarcoma cells (MG63). Ferroptosis was induced by either inhibiting glutathione peroxidase 4 (GPX4) using RSL3 or blocking all glutathione-dependent enzymes through inhibit

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7

Haffen, K., M. Kedinger, and P. Simon‐Assmann. "Mesenchyme‐Dependent Differentiation of Epithelial Progenitor Cells in the Gut." Journal of Pediatric Gastroenterology and Nutrition 6, no. 1 (1987): 14–23. http://dx.doi.org/10.1002/j.1536-4801.1987.tb09239.x.

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SummaryThe digestive tract and the gut as a paradigm represents an attractive system for the study of mechanisms involved in the differentiation of two types of progenitor cells: the endodermal cells during embryonic life and the undifferentiated crypt cells during epithelial renewal of the adult intestine. The morphological and functional events that accompany the differentiation processes of progenitor cells into the polarized epithelial cell types characteristic of the intestine appear comparable in both situations (1,2). During organogenesis of the gut, histological observations underlined

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8

Kanki, Keita, Ryota Watanabe, Le Nguyen Thai, Chun-Hao Zhao, and Kyoko Naito. "HDAC9 Is Preferentially Expressed in Dedifferentiated Hepatocellular Carcinoma Cells and Is Involved in an Anchorage-Independent Growth." Cancers 12, no. 10 (2020): 2734. http://dx.doi.org/10.3390/cancers12102734.

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Aberrant activation of histone deacetylases (HDACs) is one of the causes of tumor cell transformation in many types of cancer, however, the critical HDAC responsible for the malignant transformation remain unclear. To identify the HDAC related to the dedifferentiation of hepatocellular carcinoma (HCC) cells, we investigated the expression profile of HDACs in differentiated and undifferentiated hepatoma cells. We found that HDAC9, a member of the class II HDAC, is preferentially expressed in undifferentiated HCC cells. Analysis of 373 HCC patients in The Cancer Genome Atlas (TCGA) database reve

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9

Foudah, Dana, Marianna Monfrini, Elisabetta Donzelli, et al. "Expression of Neural Markers by Undifferentiated Mesenchymal-Like Stem Cells from Different Sources." Journal of Immunology Research 2014 (2014): 1–16. http://dx.doi.org/10.1155/2014/987678.

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The spontaneous expression of neural markers, already demonstrated in bone marrow (BM) mesenchymal stem cells (MSCs), has been considered as evidence of the MSCs’ predisposition to differentiate toward neural lineages, supporting their use in stem cell-based therapy for neural repair. In this study we have evaluated, by immunocytochemistry, immunoblotting, and flow cytometry experiments, the expression of neural markers in undifferentiated MSCs from different sources: human adipose stem cells (hASCs), human skin-derived mesenchymal stem cells (hS-MSCs), human periodontal ligament stem cells (h

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10

Coelho de Oliveira, Vanessa Carvalho, Danúbia Silva dos Santos, Leandro Vairo, et al. "Hair follicle-derived mesenchymal cells support undifferentiated growth of embryonic stem cells." Experimental and Therapeutic Medicine 13, no. 5 (2017): 1779–88. http://dx.doi.org/10.3892/etm.2017.4195.

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11

Mukonoweshuro, Blessing, Christopher JF Brown, John Fisher, and Eileen Ingham. "Immunogenicity of undifferentiated and differentiated allogeneic mouse mesenchymal stem cells." Journal of Tissue Engineering 5 (February 21, 2014): 204173141453425. http://dx.doi.org/10.1177/2041731414534255.

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12

Foudah, Dana, Juliana Redondo, Cristina Caldara, Fabrizio Carini, Giovanni Tredici, and Mariarosaria Miloso. "Expression of Neural Markers by Undifferentiated Rat Mesenchymal Stem Cells." Journal of Biomedicine and Biotechnology 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/820821.

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The spontaneous expression of neural markers by mesenchymal stem cells (MSCs) has been considered to be a demonstration of MSCs’ predisposition to differentiate towards neural lineages. In view of their application in cell therapy for neurodegenerative diseases, it is very important to deepen the knowledge about this distinctive biological property of MSCs. In this study, we evaluated the expression of neuronal and glial markers in undifferentiated rat MSCs (rMSCs) at different culture passages (from early to late). rMSCs spontaneously expressed neural markers depending on culture passage, and

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Heimburg, Dennis von, Karsten Hemmrich, Sascha Zachariah, Harald Staiger, and Norbert Pallua. "Oxygen consumption in undifferentiated versus differentiated adipogenic mesenchymal precursor cells." Respiratory Physiology & Neurobiology 146, no. 2-3 (2005): 107–16. http://dx.doi.org/10.1016/j.resp.2004.12.013.

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14

González, Miguel Angel Martínez, and Carmen Gonzalez Lois. "Undifferentiated Perivascular Cells in Myxoid Mesenchymal Tumors: An Ultrastructural Study." Ultrastructural Pathology 31, no. 2 (2007): 85–94. http://dx.doi.org/10.1080/01913120701376063.

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15

KIM, Jeonghyun, So NAGASHIMA, Junfeng WANG, Eijiro MAEDA, Dai OKUMURA, and Takeo MATSUMOTO. "Effect of hierarchical wrinkle pattern on undifferentiated mesenchymal stem cells." Proceedings of Mechanical Engineering Congress, Japan 2024 (2024): S021–02. https://doi.org/10.1299/jsmemecj.2024.s021-02.

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16

Mihaylova, Zornitsa. "Stem cells and mesenchymal stem cell markers." International Journal of Medical Science and Clinical invention 6, no. 08 (2019): 4544–47. http://dx.doi.org/10.18535/ijmsci/v6i8.03.

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Stem cells are undifferentiated cell type characterized by colonogenic ability, self-renewal and multi-lineage differentiation. They are classified into the following categories: embryonic stem cells [ESC], somatic stem cells [or adult stem cells] and induced pluripotent stem cells [iPSC]. Stem cells represent area of interest for wide range of scientists, as they are promising tool for regenerative therapy. Their differentiation ability is significantly affected by various factors of the local environment. Additional research will provide more information about the optimal cell culture condit

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Yokota, T., H. Shimokawa, S. Shibata, et al. "Insulin-like Growth Factor I Regulates Apoptosis in Condylar Cartilage." Journal of Dental Research 87, no. 2 (2008): 159–63. http://dx.doi.org/10.1177/154405910808700216.

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Endogenous insulin-like growth factor-I (IGF-I) is known to affect the growth and development of condylar cartilage. However, the critical effect of IGF-I on cell survival is still unknown. We hypothesized that endogenous IGF-I could regulate the survival of cells of the mandibular condylar cartilage. Mandibular condyles dissected from 12-day-old rats were cultured for 1, 3, and 5 days in medium containing antisense oligodeoxynucleotide (AS-ODN) for IGF-I. Real-time RT-PCR analysis showed that the levels of IGF-I and IGF binding protein (IGFBP)3 mRNAs in the AS-ODN group were significantly dec

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18

Finn, Laura S., and Kathleen Patterson. "Ovarian Sarcoma with Pathologic Features of Clear Cell Sarcoma of the Kidney." Pediatric and Developmental Pathology 3, no. 5 (2000): 487–91. http://dx.doi.org/10.1007/s100240010095.

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We report a case of an unusual sarcoma arising in the ovary of an infant girl. Histologically, the tumor was composed of clear, undifferentiated cells set in an arborizing vascular stroma. Immunohistochemical staining was positive only for vimentin. Ultrastructural evaluation demonstrated undifferentiated cells with interdigitating broad cell processes that encompassed irregular electron lucent spaces that contained flocculent extracellular material. Light and electron microscopic features of the tumor resembled a clear cell sarcoma of the kidney. Although the cell of origin is unproven, both

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19

Caetano, Guilherme, Weiguang Wang, Adriana Murashima, et al. "Tissue Constructs with Human Adipose-Derived Mesenchymal Stem Cells to Treat Bone Defects in Rats." Materials 12, no. 14 (2019): 2268. http://dx.doi.org/10.3390/ma12142268.

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The use of porous scaffolds created by additive manufacturing is considered a viable approach for the regeneration of critical-size bone defects. This paper investigates the xenotransplantation of polycaprolactone (PCL) tissue constructs seeded with differentiated and undifferentiated human adipose-derived mesenchymal stem cells (hADSCs) to treat calvarial critical-sized defect in Wistar rats. PCL scaffolds without cells were also considered. In vitro and in vivo biological evaluations were performed to assess the feasibility of these different approaches. In the case of cell seeded scaffolds,

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20

Lee, S. L., E. J. Kang, B. G. Jeon, et al. "41 PRODUCTION OF CLONED MINIATURE PIGS USING BONE MARROW MESENCHYMAL STEM CELLS." Reproduction, Fertility and Development 21, no. 1 (2009): 120. http://dx.doi.org/10.1071/rdv21n1ab41.

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The cloning of miniature pigs (Mini-pig) are considered to advance in genetic engineering technology and xenotransplantation. A few researches have recently been reported successfully produce cloned Mini-pigs using somatic cells, however its efficiency is still low. The present study was aimed to successfully produce cloned Mini-pigs derived from bone marrow mesenchymal stem cells (MSCs) by NT, and compared the developmental ability of cloned Mini-pigs between fetal fibroblast (FF) and differentiated MSCs. For the production of the cloned Mini-pig derived from MSCs, MSCs were isolated from a 1

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21

Chen, Lan, Noboru Fukuda, Shoichi Shimizu, et al. "Role of complement 3 in renin generation during the differentiation of mesenchymal stem cells to smooth muscle cells." American Journal of Physiology-Cell Physiology 318, no. 5 (2020): C981—C990. http://dx.doi.org/10.1152/ajpcell.00461.2019.

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We showed that increased expression of complement 3 (C3) induces dedifferentiation of mesenchymal cells and epithelial mesenchymal transition, which activate the local renin-angiotensin system (RAS) that contributes to cardiovascular and renal remodeling in spontaneously hypertensive rats (SHRs). In the present study, to investigate contributions of C3 to the development of the pathogenesis of hypertension, we evaluated the formation of renin-producing cells and roles of C3 in renin generation during differentiation of primary bone marrow-mesenchymal stem cells (MSCs) from C57BL/6 mice, Wistar

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22

Roszek, Katarzyna, Agnieszka Błaszczak, Magdalena Wujak, and Michał Komoszyński. "Nucleotides metabolizing ectoenzymes as possible markers of mesenchymal stem cell osteogenic differentiation." Biochemistry and Cell Biology 91, no. 3 (2013): 176–81. http://dx.doi.org/10.1139/bcb-2012-0093.

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Growing murine mesenchymal stem cells (mMSCs) from mouse bone marrow decreased their rate of proliferation in the presence of benzoylbenzoyl-ATP persistently, but the inhibitory effect of ATP was strong only in a concentration of 50 μmol·L−1 and lasted for 48 h in culture. These results hinted at ATP hydrolysis by the cell surface enzymes at the lower concentrations and thus it may be not able to inhibit MSCs. By using ATP, ADP, or AMP as substrates, we tested the ectonucleotidase activity on the surface of undifferentiated MSCs and MSC-derived osteoblasts. Here, we report that although nucleo

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23

Janz, Felipe de Lara, Adriana de Aguiar Debes, Rita de Cássia Cavaglieri, et al. "Evaluation of Distinct Freezing Methods and Cryoprotectants for Human Amniotic Fluid Stem Cells Cryopreservation." Journal of Biomedicine and Biotechnology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/649353.

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Amniotic fluid (AF) was described as a potential source of mesenchymal stem cells (MSCs) for biomedicine purposes. Therefore, evaluation of alternative cryoprotectants and freezing protocols capable to maintain the viability and stemness of these cells after cooling is still needed. AF stem cells (AFSCs) were tested for different freezing methods and cryoprotectants. Cell viability, gene expression, surface markers, and plasticity were evaluated after thawing. AFSCs expressed undifferentiated genes Oct4 and Nanog; presented typical markers (CD29, CD44, CD90, and CD105) and were able to differe

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Mugrauer, G., and P. Ekblom. "Contrasting expression patterns of three members of the myc family of protooncogenes in the developing and adult mouse kidney." Journal of Cell Biology 112, no. 1 (1991): 13–25. http://dx.doi.org/10.1083/jcb.112.1.13.

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The myc family of protooncogenes encode similar but distinct nuclear proteins. Since N-myc, c-myc, and L-myc have been found to be expressed in the newborn kidney, we studied their expression during murine kidney development. By organ culture studies and in situ hybridization of tissue sections, we found that each of the three members of the myc gene family shows a remarkably distinct expression pattern during kidney development. It is known that mesenchymal stem cells of the embryonic kidney convert into epithelium if properly induced. We demonstrate the N-myc expression increases during the

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Cai, Yiming, Jun Yao, Dean N. Pan, et al. "Abstract 3009: ATRX loss blocks the differentiation of mesenchymal stem cells and promotes undifferentiated sarcoma development." Cancer Research 84, no. 6_Supplement (2024): 3009. http://dx.doi.org/10.1158/1538-7445.am2024-3009.

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Abstract Soft tissue sarcomas (STSs) are a collection of rare tumor types originated from the mesenchymal tissues. Among the over 70 histological subtypes of STS, undifferentiated sarcoma (US), which lacks any discernible morphological features of differentiated tissues, accounts for over 20% of all STSs and is correlated with high tumor grade and poor prognosis. Recent genomic profiling in US has identified p53 and ATRX among the most frequently mutated or deleted genes. ATRX is a SWI/SNF2 type of chromatin remodeling factor which functions in a histone variant H3.3-specific chaperone complex

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Le Blanc, Katarina, Charlotte Tammik, Kerstin Rosendahl, Eva Zetterberg, and Olle Ringdén. "HLA expression and immunologic propertiesof differentiated and undifferentiated mesenchymal stem cells." Experimental Hematology 31, no. 10 (2003): 890–96. http://dx.doi.org/10.1016/s0301-472x(03)00110-3.

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27

Bibb, C. A., A. G. Pullinger, and F. Baldioceda. "The Relationship of Undifferentiated Mesenchymal Cells to TMJ Articular Tissue Thickness." Journal of Dental Research 71, no. 11 (1992): 1816–21. http://dx.doi.org/10.1177/00220345920710111001.

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Undifferentiated mesenchymal (UM) cells, the progenitor cells of the cartilage layer, have been assigned a significant role in TMJ articular tissue maintenance. This was based on reports of UM cell reduction with increased soft-tissue thickness for the condyle and temporal component. However, the strength of this inverse relationship was not presented and remained unclear. The purpose of the present study was to assess the strength of the correlation between UM cell presence and soft-tissue thickness in young adult TMJs at autopsy. Sagittal histological sections from the central thirds of 50 j

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28

Roman, Alexandra, Andrada Şoancă, Adrian Florea, and Emőke Páll. "In Vitro Characterization of Multipotent Mesenchymal Stromal Cells Isolated from Palatal Subepithelial Tissue Grafts." Microscopy and Microanalysis 19, no. 2 (2013): 370–80. http://dx.doi.org/10.1017/s143192761201433x.

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AbstractThe aim of this study was to analyze whether the mesenchymal stromal cells (MSCs) isolated from palatal tissue grafts harvested in order to cover gingival recessions have the basic characteristics of stem cells. The palatal tissue cells were processed using a special culture medium that stimulated the development of only undifferentiated cellular lines. Cells at passage 4 were evaluated by flow cytometry to examine the expression of specific surface markers and were tested for multilineage differentiation capacity. These cells collected at passage 4 were also investigated for the capac

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Uchasova, E. G., Yu A. Dyleva, T. A. Slesareva, et al. "Osteogenic potential of mesenchymal stem cells of epicardial adipose tissue in patients with coronary heart disease." Bulletin of Siberian Medicine 24, no. 1 (2025): 86–95. https://doi.org/10.20538/1682-0363-2025-1-86-95.

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Aim. To assess the osteogenic potential of mesenchymal stem cells (MSCs) of epicardial adipose tissue (EAT) in patients with stable coronary heart disease based on obtaining gene profiles (osteogenesis markers). Materials and methods. In EAT MSCs, the expression levels of the RUNX2 (RUNX transcription factor encoding gene), BGLAP (osteocalcin encoding gene), SPP1 (osteopontin encoding gene), SP7 (Osterix encoding gene) genes were determined using real-time polymerase chain reaction (PCR). Using immunofluorescence staining, the amount of RUNX2, osteocalcin, osteopontin, and Osterix proteins was

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Gimonet, Valérie, Laurence Bussieres, Anissa A. Medjebeur, Bernard Gasser, Brigitte Lelongt, and Kathleen Laborde. "Nephrogenesis and angiotensin II receptor subtypes gene expression in the fetal lamb." American Journal of Physiology-Renal Physiology 274, no. 6 (1998): F1062—F1069. http://dx.doi.org/10.1152/ajprenal.1998.274.6.f1062.

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To investigate the role of angiotensin II (ANG II) in nephrogenesis, a developmental study of renal AT1 and AT2 receptor mRNA expression was performed in parallel with the quantitative and qualitative analysis of metanephros development in fetal lamb from 60 to 140 days of gestation. Both ANG II receptor subtypes were expressed early during nephrogenesis but displayed specific spatial and temporal distribution during gestation. High-AT2 mRNA expression took place in the outermost nephrogenic area and in the undifferentiated mesenchymal cells surrounding the ampulla; level of AT2 expression in

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31

Petrella, Francesco, Isabella Rimoldi, Stefania Rizzo, and Lorenzo Spaggiari. "Mesenchymal Stromal Cells for Antineoplastic Drug Loading and Delivery." Medicines 4, no. 4 (2017): 87. http://dx.doi.org/10.3390/medicines4040087.

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Mesenchymal stromal cells are a population of undifferentiated multipotent adult cells possessing extensive self-renewal properties and the potential to differentiate into a variety of mesenchymal lineage cells. They express broad anti-inflammatory and immunomodulatory activity on the immune system and after transplantation can interact with the surrounding microenvironment, promoting tissue healing and regeneration. For this reason, mesenchymal stromal cells have been widely used in regenerative medicine, both in preclinical and clinical settings. Another clinical application of mesenchymal s

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Gang, Eun J., Darko Bosnakovski, Camila A. Figueiredo, Jan W. Visser, and Rita C. R. Perlingeiro. "SSEA-4 identifies mesenchymal stem cells from bone marrow." Blood 109, no. 4 (2006): 1743–51. http://dx.doi.org/10.1182/blood-2005-11-010504.

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Abstract Adult bone marrow (BM) contains hematopoietic stem cells (HSCs) as well as a nonhematopoietic, stromal cell population. Within this stromal population are mesenchymal stem cells (MSCs), which not only support hematopoiesis but also differentiate into multiple lineages, including fat, bone, and cartilage. Because of this multipotentiality, the MSC is an attractive candidate for clinical applications to repair or regenerate damaged tissues of mesenchymal origin. However, research progress has been hampered by the limited existing knowledge of the biology of these cells, particularly by

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De Kok, I. J., K. C. Hicok, R. J. Padilla, R. G. Young, and L. F. Cooper. "Effect of Vitamin D Pretreatment of Human Mesenchymal Stem Cells on Ectopic Bone Formation." Journal of Oral Implantology 32, no. 3 (2006): 103–9. http://dx.doi.org/10.1563/760.1.

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Abstract Adult mesenchymal stem cells (MSCs) are used in contemporary strategies for tissue engineering. The MSC is able to form bone following implantation as undifferentiated cells adherent to hydroxyapatite (HA)/tricalcium phosphate (TCP) scaffolds. Previous investigators have demonstrated that human MSCs (hMSCs) can be differentiated to osteoblasts in vitro by the inclusion of vitamin D and ascorbic acid. The aim of this study was to compare the osteogenic potential of predifferentiated and undifferentiated bone marrow–derived, culture-expanded hMSCs adherent to synthetic HA/TCP (60%/40%)

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Katou-Ichikawa, Chisa, Hironobu Nishina, Miyuu Tanaka, et al. "Participation of Somatic Stem Cells, Labeled by a Unique Antibody (A3) Recognizing Both N-glycan and Peptide, to Hair Follicle Cycle and Cutaneous Wound Healing in Rats." International Journal of Molecular Sciences 21, no. 11 (2020): 3806. http://dx.doi.org/10.3390/ijms21113806.

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A monoclonal antibody (A3) was generated by using rat malignant fibrous histiocytoma (MFH) cells as the antigen. Generally, MFH is considered to be a sarcoma derived from undifferentiated mesenchymal cells. Molecular biological analyses using the lysate of rat MFH cells revealed that A3 is a conformation specific antibody recognizing both N-glycan and peptide. A3-labeled cells in bone marrow were regarded as somatic stem cells, because the cells partly coexpressed CD90 and CD105 (both immature mesenchymal markers). In the hair follicle cycle, particularly the anagen, the immature epithelial ce

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Petrella, Francesco, Enrico Mario Cassina, Lidia Libretti, Emanuele Pirondini, Federico Raveglia, and Antonio Tuoro. "Mesenchymal Stromal Cell Therapy for Thoracic Surgeons: An Update." Journal of Personalized Medicine 13, no. 12 (2023): 1632. http://dx.doi.org/10.3390/jpm13121632.

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Stem cells are undifferentiated cells presenting extensive self-renewal features and the ability to differentiate “in vitro” and “in vivo” into a range of lineage cells, like chondrogenic, osteogenic and adipogenic lineages when cultured in specific inducing media. Two major domains of clinical applications of stem cells in thoracic surgery have been investigated: regenerative medicine, which is a section of translational research in tissue engineering focusing on the replacement, renewal or regeneration of cells, tissues and organs to re-establish damaged physiologic functions; drug loading a

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Cai, Yiming, Jun Yao, Dean Pan, et al. "Abstract 1435: ATRX loss blocks the differentiation of mesenchymal stem cells and advances undifferentiated sarcoma development." Cancer Research 85, no. 8_Supplement_1 (2025): 1435. https://doi.org/10.1158/1538-7445.am2025-1435.

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Abstract Soft tissue sarcomas (STSs) are a collection of rare tumor types originated from the mesenchymal tissues. Among the over 70 histological subtypes of STS, undifferentiated sarcoma (US), which lacks any discernible morphological features of differentiated tissues, accounts for over 20% of all STSs and is correlated with high tumor grade and poor prognosis. Recent genomic profiling in US has identified p53 and ATRX among the most frequently mutated or deleted genes. ATRX is a SWI/SNF2 type of chromatin remodeling factor which functions in a histone variant H3.3-specific chaperone complex

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Abdolreza, Esmaeilzadeh 1. "Mesenchymal Stem Cell as a Vector for Gene and Cell therapy Strategies." Studies on Stem Cells Research and Therapy 1, no. 1 (2015): 017–18. https://doi.org/10.17352/sscrt.000005.

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Stem cells are undifferentiated biological cells that able to maintain undifferentiated state through cell division and give rise to any mature cell type. They are almost divided into embryonic (ESC) and adult stem cells (ASC). ASCs have lineage restriction in compare to ESCs which they cannot differentiate into all 3 layers (ectoderm, mesoderm and endoderm) [1,2]. The most characterized ASC population in bone marrow is hematopoietic (HSC) and mesenchymal stem cells (MSC). HSC was transplanted in many blood related diseases like as leukemia and HIV infection [3-6]. In addition to bone marrow t

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Balhara, Bharti, Alison Burkart, Vehap Topcu, et al. "Severe Insulin Resistance Alters Metabolism in Mesenchymal Progenitor Cells." Endocrinology 156, no. 6 (2015): 2039–48. http://dx.doi.org/10.1210/en.2014-1403.

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Abstract Donohue syndrome (DS) is characterized by severe insulin resistance due to mutations in the insulin receptor (INSR) gene. To identify molecular defects contributing to metabolic dysregulation in DS in the undifferentiated state, we generated mesenchymal progenitor cells (MPCs) from induced pluripotent stem cells derived from a 4-week-old female with DS and a healthy newborn male (control). INSR mRNA and protein were significantly reduced in DS MPC (for β-subunit, 64% and 89% reduction, respectively, P &lt; .05), but IGF1R mRNA and protein did not differ vs control. Insulin-stimula

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Baek, Jin-Young, Yun-Hee Rhee, Kwang-Yul Cha, and Hyung-Min Chung. "Human Fetal Liver Derived Stem Cells Can Be Support the Maintenance of Human Embryonic Stem Cells." Blood 104, no. 11 (2004): 4264. http://dx.doi.org/10.1182/blood.v104.11.4264.4264.

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Abstract Prolonged propagation of human embryonic stem (ES) cells is currently achieved by co-culture with primary or immortalized mouse embryonic fibroblast (MEF) cells. In order to replace the heterologous with homologous co-culture systems, an attempt was made using mononuclear cells derived from human fetal liver. Human fetal liver-derived mesenchymal-like stem cells (FL-MLSC) can be maintained for the prolonged period of time. They showed the characteristics of mesenchymal stem cells in various aspects. They retained a normal diploid karyotype and growth characteristics over the successiv

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Krishnamurthy, Vani, Sheela Devi C. Shivalingiah, Sunila Ravishankar, and Gubbanna V. Manjunath. "Morphologic Heterogeneity in Carcinosarcoma of the Gallbladder: Report of a Rare Cases." Case Reports in Pathology 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/929654.

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Carcinosarcoma is a rare tumor composed of variable proportions of carcinomatous and sarcomatous elements and comprises less than one percent of all gallbladder malignancies. In most reported cases of carcinosarcoma of gallbladder, the epithelial component is adenocarcinoma. The mesenchymal component varies from homogenous sarcoma to more heterotopic elements like malignant bone, cartilage, and other mesenchymal tissues. We report a rare case of carcinosarcoma of the gallbladder in an 83-year-old male, with the carcinomatous component represented by undifferentiated carcinoma (spindle and gian

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Wajstaub, Sandra, Pratima Deb, and Katherine A. Chorneyko. "Undifferentiated Sarcoma of the Parotid Gland With Osseous Metaplasia." Archives of Pathology & Laboratory Medicine 126, no. 7 (2002): 849–52. http://dx.doi.org/10.5858/2002-126-0849-usotpg.

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Abstract Malignant spindle cell tumors of the parotid gland are a diagnostic challenge. We present an unusual case of such a tumor that occurred in the right parotid gland of a 53-year-old man. The clinical and histologic assessments were consistent with a primary sarcoma of the parotid gland. The tumor was composed of sheets of pleomorphic, spindle-shaped cells with an area of bone formation. By immunohistochemistry, the tumor cells were positive for vimentin and negative for epithelial markers. Electron microscopy revealed mesenchymal cells containing moderate amounts of rough endoplasmic re

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Sariola, H., K. Holm, and S. Henke-Fahle. "Early innervation of the metanephric kidney." Development 104, no. 4 (1988): 589–99. http://dx.doi.org/10.1242/dev.104.4.589.

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During kidney differentiation, the nephrogenic mesenchyme converts into renal tubules and the ureter bud branches to form the collecting system. Here we show that in the early undifferentiated kidney rudiment there is a third cell type present. In whole-mount preparations of cultured undifferentiated metanephric kidneys, neurones can be detected by immunohistochemical means with antibodies against the neurofilament triplet, 13AA8, and against neuronal cell surface gangliosides, Q211. Clusters of neuronal cell bodies can be seen in the mesenchyme close to the ureter bud. The terminal endings of

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Matsunaga, Shunji, Kosei Ijiri, Takashi Sakou, and Norio Morimoto. "Immunohistochemical study of activating osteoblasts from undifferentiated mesenchymal cells by electrical stimulation." Bone 14, no. 3 (1993): 327–32. http://dx.doi.org/10.1016/8756-3282(93)90160-c.

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Omar, Thoria Ahmed, Eman Sweed, Dina Sweed, Rawhia Hassan Eledel, Dalia Hosny Abou-Elela, and Gehad Hikal. "Mesenchymal Stem Cells for the Treatment of Acetic Acid-Induced Ulcerative Colitis in Rats." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 1478–86. http://dx.doi.org/10.3889/oamjms.2022.10686.

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Background: Ulcerative colitis (UC) is an autoimmune inflammatory bowel disease, characterized by chronic and relapsing inflammation of the intestinal mucosa. Clinical treatments fail to reduce inflammation and induce side effects in nearly 30% of patients. Mesenchymal stem cells (MSCs) are immunomodulatory agents that can encourage tissue repair and regeneration. Aim: To investigate the ability of MSCs to differentiate into enterocytes under the mediation of activin a, fibroblastic growth factor 2, and epidermal growth factors and to study the effect of administering MSCs to rats with a

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Beqaj, Safedin, Sandhya Jakkaraju, Raymond R. Mattingly, Desi Pan, and Lucia Schuger. "High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis." Journal of Cell Biology 156, no. 5 (2002): 893–903. http://dx.doi.org/10.1083/jcb.200107049.

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Round embryonic mesenchymal cells have the potential to differentiate into smooth muscle (SM) cells upon spreading/elongation (Yang, Y., K.C. Palmer, N. Relan, C. Diglio, and L. Schuger. 1998. Development. 125:2621–2629; Yang, Y., N.K. Relan, D.A. Przywara, and L. Schuger. 1999. Development. 126:3027–3033; Yang, Y., S. Beqaj, P. Kemp, I. Ariel, and L. Schuger. 2000. J. Clin. Invest. 106:1321–1330). In the developing lung, this process is stimulated by peribronchial accumulation of laminin (LN)-2 (Relan, N.K., Y. Yang, S. Beqaj, J.H. Miner, and L. Schuger. 1999. J. Cell Biol. 147:1341–1350). He

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Yoshikawa, Hideki, Kunio Takaoka, and Keiro Ono. "Bone Morphogenetic Proteins (BMPs) in Musculoskeletal Oncology." Journal of Musculoskeletal Research 01, no. 01 (1997): 1–12. http://dx.doi.org/10.1142/s0218957797000025.

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Current knowledge of bone morphogenetic proteins (BMPs) in musculoskeletal oncology is reviewed in this paper. Bone morphogenetic activity, manifesting as ectopic bone induction, is present in a proportion of murine and human osteosarcoma tissues and cells in culture. In osteosarcoma, BMPs effect reactive bone formation including periosteal reactions by normal osteoblasts rather than through the production of tumorous osteoid by tumor cells. BMP-producing osteosarcomas may contain less differentiated mesenchymal cells, resulting in a poorer prognosis for these patients. BMP-2/4 proteins are al

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Ramazzotti, Ratti, Fiume, et al. "Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments." International Journal of Molecular Sciences 20, no. 8 (2019): 2026. http://dx.doi.org/10.3390/ijms20082026.

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Stem cells are undifferentiated cells that can give rise to several different cell types and can self-renew. Given their ability to differentiate into different lineages, stem cells retain huge therapeutic potential for regenerative medicine. Therefore, the understanding of the signaling pathways involved in stem cell pluripotency maintenance and differentiation has a paramount importance in order to understand these biological processes and to develop therapeutic strategies. In this review, we focus on phosphoinositide 3 kinase (PI3K) since its signaling pathway regulates many cellular proces

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Fontana, Fabrizio, Michele Sommariva, Martina Anselmi, Francesca Bianchi, Patrizia Limonta, and Nicoletta Gagliano. "Differentiation States of Phenotypic Transition of Melanoma Cells Are Revealed by 3D Cell Cultures." Cells 13, no. 2 (2024): 181. http://dx.doi.org/10.3390/cells13020181.

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Melanoma is characterized by high metastatic potential favored by the epithelial-to-mesenchymal transition (EMT), leading melanoma cells to exhibit a spectrum of typical EMT markers. This study aimed to analyze the expression of EMT markers in A375 and BLM melanoma cell lines cultured in 2D monolayers and 3D spheroids using morphological and molecular methods. The expression of EMT markers was strongly affected by 3D arrangement and revealed a hybrid phenotype for the two cell lines. Indeed, although E-cadherin was almost undetectable in both A375 and BLM cells, cortical actin was detected in

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Kalmukova, O. "Stem cells in nail unit of mammalians." Cell and Organ Transplantology 4, no. 1 (2016): 138–43. http://dx.doi.org/10.22494/cot.v4i1.1.

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The review analyzes the current state of experimental studies on the ability to obtain and cultivate stem cells from the nail organ and their possible involvement in the regeneration of a limb. It has been known that the nail unit consists of a pool of undifferentiated cells which provide sustained growth and nail repair throughout life. But, nowadays the issue of stem cell niche localization in the nail organ remains unresolved. Also, researchers demonstrated involvement of these cells in the restoration of amputated limbs, in particular, through activation of certain signaling pathways (Wnt,

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Fedele, Monica, Sabrina Battista, and Laura Cerchia. "Metabolic Reprogramming in Thyroid Cancer: Role of the Epithelial-Mesenchymal Transition." Endocrines 2, no. 4 (2021): 427–38. http://dx.doi.org/10.3390/endocrines2040038.

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Thyroid cancer (TC) represents the most common endocrine malignancy, with an increasing incidence all over the world. Papillary TC (PTC), a differentiated TC subtype, is the most common and, even though it has an excellent prognosis following radioiodine (RAI) ablation, it shows an aggressive behavior in 20–30% of cases, becoming RAI-resistant and/or metastatic. On the other side, anaplastic thyroid carcinoma (ATC), the most undifferentiated TC, is a rare but devastating disease, indicating that progression of differentiated to undifferentiated forms of TC could be responsible for RAI-resistan

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