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1

Grün, Sonja, Markus Diesmann, and Ad Aertsen. "Unitary Events in Multiple Single-Neuron Spiking Activity: II. Nonstationary Data." Neural Computation 14, no. 1 (2002): 81–119. http://dx.doi.org/10.1162/089976602753284464.

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In order to detect members of a functional group (cell assembly) in simultaneously recorded neuronal spiking activity, we adopted the widely used operational definition that membership in a common assembly is expressed in near-simultaneous spike activity. Unitary event analysis, a statistical method to detect the significant occurrence of coincident spiking activity in stationary data, was recently developed (see the companion article in this issue). The technique for the detection of unitary events is based on the assumption that the underlying processes are stationary in time. This requireme
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2

Roy, A., P. N. Steinmetz, and E. Niebur. "Rate Limitations of Unitary Event Analysis." Neural Computation 12, no. 9 (2000): 2063–82. http://dx.doi.org/10.1162/089976600300015060.

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Unitary event analysis is a new method for detecting episodes of synchronized neural activity (Riehle, Grüun, Diesmann, & Aertsen, 1997). It detects time intervals that contain coincident firing at higher rates than would be expected if the neurons fired as independent inhomogeneous Poisson processes; all coincidences in such intervals are called unitary events (UEs). Changes in the frequency of UEs that are correlated with behavioral states may indicate synchronization of neural firing that mediates or represents the behavioral state. We show that UE analysis is subject to severe limitati
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Grün, Sonja, Markus Diesmann, and Ad Aertsen. "Unitary Events in Multiple Single-Neuron Spiking Activity: I. Detection and Significance." Neural Computation 14, no. 1 (2002): 43–80. http://dx.doi.org/10.1162/089976602753284455.

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It has been proposed that cortical neurons organize dynamically into functional groups (cell assemblies) by the temporal structure of their joint spiking activity. Here, we describe a novel method to detect conspicuous patterns of coincident joint spike activity among simultaneously recorded single neurons. The statistical significance of these unitary events of coincident joint spike activity is evaluated by the joint-surprise. The method is tested and calibrated on the basis of simulated, stationary spike trains of independently firing neurons, into which coincident joint spike events were i
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4

Tuleau-Malot, Christine, Amel Rouis, Franck Grammont, and Patricia Reynaud-Bouret. "Multiple Tests Based on a Gaussian Approximation of the Unitary Events Method with Delayed Coincidence Count." Neural Computation 26, no. 7 (2014): 1408–54. http://dx.doi.org/10.1162/neco_a_00604.

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The unitary events (UE) method is one of the most popular and efficient methods used over the past decade to detect patterns of coincident joint spike activity among simultaneously recorded neurons. The detection of coincidences is usually based on binned coincidence count (Grün, 1996 ), which is known to be subject to loss in synchrony detection (Grün, Diesmann, Grammont, Riehle, & Aertsen, 1999 ). This defect has been corrected by the multiple shift coincidence count (Grün et al., 1999 ). The statistical properties of this count have not been further investigated until this work, the for
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5

Jackett, Sarah-Jane, Peter O. Baumgartner, and Alexandre N. Bandini. "A new low-latitude late Paleocene-early Eocene radiolarian biozonation based on unitary associations: applications for accreted terranes." Stratigraphy 5, no. 1 (2008): 39–62. http://dx.doi.org/10.29041/strat.05.1.04.

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The late Paleocene – early Eocene sequences of DSDP Leg 10 Sites 86, 94, 95, and 96, Leg 43 Site 384 and ODP Leg 171B Hole 1051A have been re-sampled and re-examined for radiolarians. A new late Paleocene to early Eocene low-latitude radiolarian zonation suited for the correlation of accreted terranes is established by using the Unitary Association (UA) method. This method has the property of attributing equal weight to each species occurrence, which has the advantage of not being dependant on a limited set of key datums. Twenty-two UAs have been erected and correlated to the existing age mode
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Zagan, Ionel, and Vasile Găitan. "Hardware RTOS: Custom Scheduler Implementation Based on Multiple Pipeline Registers and MIPS32 Architecture." Electronics 8, no. 2 (2019): 211. http://dx.doi.org/10.3390/electronics8020211.

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The task context switch operation, the inter-task synchronization and communication mechanisms, as well as the jitter occurred in treating aperiodic events, are crucial factors in implementing real-time operating systems (RTOS). In practice and literature, several solutions can be identified for improving the response speed and performance of real-time systems. Software implementations of RTOS-specific functions can generate significant delays, adversely affecting the deadlines required for certain applications. This paper presents an original implementation of a dedicated processor, based on
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7

Choudhury, Masudul. "Subjective probability and financial valuation: contrasting paradigms." Journal of Financial Reporting and Accounting 13, no. 1 (2015): 20–38. http://dx.doi.org/10.1108/jfra-05-2014-0044.

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Purpose – The purpose of this paper is to theorize the existing idea of subjective probability a la Keynes’s Treatise on Probability Theory. Then to show that, under the especial kind of financial valuation model in the absence of interest rate and speculation, subjective probability is not of a major concern in Islamic financial theory. Design/methodology/approach – The topic is of an epistemological nature premised on the Islamic unity of knowledge and the world-system with special attention given to the formulation of the financial model for evaluation under its unitary characteristic at ea
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8

Reinagel, Pamela, Dwayne Godwin, S. Murray Sherman, and Christof Koch. "Encoding of Visual Information by LGN Bursts." Journal of Neurophysiology 81, no. 5 (1999): 2558–69. http://dx.doi.org/10.1152/jn.1999.81.5.2558.

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Encoding of visual information by LGN bursts. Thalamic relay cells respond to visual stimuli either in burst mode, as a result of activation of a low-threshold Ca2+ conductance, or in tonic mode, when this conductance is inactive. We investigated the role of these two response modes for the encoding of the time course of dynamic visual stimuli, based on extracellular recordings of 35 relay cells from the lateral geniculate nucleus of anesthetized cats. We presented a spatially optimized visual stimulus whose contrast fluctuated randomly in time with frequencies of up to 32 Hz. We estimated the
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9

EVELPIDOU, Niki, Niki POLYKRETI, Anna KARKANI, Eirini KARDARA, Stamatina SEFERLI, and Theofilos VALSAMIDIS. "Modelling flood hazard at Paratrechos/Peritsi stream, Naxos Island (Cyclades, Greece)." Revista de Geomorfologie 20, no. 1 (2018): 123–29. http://dx.doi.org/10.21094/rg.2018.035.

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Flash floods are one of the most significant natural hazards in the Mediterranean, affecting most basins in the region. Flash floods usually occur in ephemeral streams after particularly heavy rainfall. Although the average annual rainfall in the Cycladic islands (Greece) does not exceed 400 mm, flash floods are frequent, since most of that rainfall is often concentrated in few but very intense events. The case study is the drainage basin of Paratrechos or Peritsi stream in Naxos Island. This particular basin was selected due to the recorded flood events, the stream's proximity to the city tha
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10

Vodyasova, Lyubov P. "Ways to quantify of abstract nouns in the modern Erzya language." Finno-Ugric World 13, no. 3 (2021): 233–42. http://dx.doi.org/10.15507/2076-2577.013.2021.03.233-242.

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Introduction. The article analyzes abstract nouns based on the material of the modern Erzya language, which in various contexts can be concretized, becoming the basis for the formation of their plural. These lexemes begin to express a real quantitative meaning, in other words, they acquire the ability to quantify. The purpose of the article is to identify and describe the contexts in which abstract plural nouns denote quantifiable relations. Materials and Methods. The main method is structural-semantic description, used for direct observation of contexts when abstract nouns express quantitativ
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11

Grün, Sonja. "Data-Driven Significance Estimation for Precise Spike Correlation." Journal of Neurophysiology 101, no. 3 (2009): 1126–40. http://dx.doi.org/10.1152/jn.00093.2008.

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The mechanisms underlying neuronal coding and, in particular, the role of temporal spike coordination are hotly debated. However, this debate is often confounded by an implicit discussion about the use of appropriate analysis methods. To avoid incorrect interpretation of data, the analysis of simultaneous spike trains for precise spike correlation needs to be properly adjusted to the features of the experimental spike trains. In particular, nonstationarity of the firing of individual neurons in time or across trials, a spike train structure deviating from Poisson, or a co-occurrence of such fe
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12

ANASTASIU, Mădălina, and Răzvan Adrian CĂLUGĂREANU. "DESIGN OF LEARNING UNITS FOR SCHOOL PHYSICAL EDUCATION WITH 6TH GRADE STUDENTS." UNIVERSITY ARENA 1, no. 1/2018 (2018): 13–17. https://doi.org/10.62229/uai_1_18-2.

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Background. From the unitary documents of the teacher of physical education, the didactic design acquires a personalized and individual character, regarding the distribution of the learning units in lessons and throughout the school year, the joining of the learning units into lessons, the placement of the test events for the sunmative evaluation and of the tests stipulated by the National School System of Evaluation, as well as those established by the teacher in the structure of the school year. Objectives. This research aimed at the following objectives: to present the theoretical documenta
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13

Lipton, Stuart A. "GABA-activated single channel currents in outside-out membrane patches from rat retinal ganglion cells." Visual Neuroscience 3, no. 3 (1989): 275–79. http://dx.doi.org/10.1017/s0952523800010026.

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Abstractγ-aminobutyric acid (GABA) evokes large whole-cell currents in solitary mammalian retinal ganglion cells studied by the patch-clamp method. This evidence suggests that GABA acts directly on the retinal ganglion cells as an inhibitory transmitter as it does elsewhere in the mammalian central nervous system. Here, single-channel recordings of the currents underlying the GABA-induced responses were studied in outside-out patches of cell membrane. In some other preparations, single GABAA channels recorded in the excised patch configuration have been shown to have altered properties in comp
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14

Gonzales, Albert L., Gregory C. Amberg, and Scott Earley. "Ca2+ release from the sarcoplasmic reticulum is required for sustained TRPM4 activity in cerebral artery smooth muscle cells." American Journal of Physiology-Cell Physiology 299, no. 2 (2010): C279—C288. http://dx.doi.org/10.1152/ajpcell.00550.2009.

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The melastatin transient receptor potential (TRP) channel TRPM4 is a critical regulator of vascular smooth muscle cell membrane potential and contractility. Activation of the channel is Ca2+-dependent, but prolonged exposure to high (>1 μM) levels of intracellular Ca2+ causes rapid (within ∼2 min) desensitization of TRPM4 currents under conventional whole cell and inside-out patch-clamp conditions. The goal of the present study was to establish a novel method to record sustained TRPM4 currents in smooth muscle cells under near-physiological conditions. Using the amphotericin B-perforated pa
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15

Sacca, L., G. Toffolo, and C. Cobelli. "V-A and A-V modes in whole body and regional kinetics: domain of validity from a physiological model." American Journal of Physiology-Endocrinology and Metabolism 263, no. 4 (1992): E597—E606. http://dx.doi.org/10.1152/ajpendo.1992.263.4.e597.

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In turnover studies, both at whole body and regional level, sources of tracer and tracee are in general nonidentical thus resulting in nonuniformity of specific activity (SA). Guidelines are available in literature to deal with the heterogeneous SA problem, and either the V-A or A-V modes, based on the arterial and mixed venous blood SA, respectively, have been recommended for different substrates. In particular, the A-V mode is considered the method of choice for studying lactate, amino acids, free fatty acid, etc. Guidelines are based on specific models chosen to describe kinetic and circula
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16

Lubis, Hasrita, Nurhayati Nurhayati, Pulung Sumantri, Muhammad Ricky Hardiyansyah, Surya Aymanda Nababan, and Muhammad Adika Nugraha. "DATOK INSTITUTE LAKSAMANA WEAVING MOTIVES OF MALAY SONGKET WEAVING IN LANGKAT: STUDY OF LOCAL WISDOM CHARACTER EDUCATION MODELS." JUPIIS: JURNAL PENDIDIKAN ILMU-ILMU SOSIAL 15, no. 1 (2023): 129. http://dx.doi.org/10.24114/jupiis.v15i1.46886.

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The Datok Laksamana Institute for Typical Malay Songket Weaving in Langkat Dusun V Plantation Village, Tanjung Pura Langkat District, has been revitalized since 1986 by the Government through training for development. Directional development explores local wisdom that has existed since the mulda of the Langkat sultanate around the 18th century. This type of qualitative descriptive research is a research method that utilizes qualitative data and is described in descriptive history. This type of qualitative descriptive research is often used to analyze events, phenomena, or situations socially.
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17

Pauluis, Quentin, and Stuart N. Baker. "An Accurate Measure of the Instantaneous Discharge Probability, with Application to Unitary Joint-Event Analysis." Neural Computation 12, no. 3 (2000): 647–69. http://dx.doi.org/10.1162/089976600300015736.

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We present an estimate for the instantaneous discharge probability of a neurone, based on single-trial spike-train analysis. By detecting points where the neurone abruptly changes its firing rate and treating them specially, the method is able to achieve smooth estimates yet avoid the blurring of significant changes. This estimate of instantaneous discharge probability is then applied to the method of unitary event analysis. We show that the unitary event analysis as originally conceived is highly sensitive to firing-rate nonstationarities and covariations, but that it can be considerably impr
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18

Higgs, Matthew H., and Charles J. Wilson. "Unitary synaptic connections among substantia nigra pars reticulata neurons." Journal of Neurophysiology 115, no. 6 (2016): 2814–29. http://dx.doi.org/10.1152/jn.00094.2016.

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Neurons in substantia nigra pars reticulata (SNr) are synaptically coupled by local axon collaterals, providing a potential mechanism for local signal processing. Because SNr neurons fire spontaneously, these synapses are constantly active. To investigate their properties, we recorded spontaneous inhibitory postsynaptic currents (sIPSCs) from SNr neurons in brain slices, in which afferents from upstream nuclei are severed, and the cells fire rhythmically. The sIPSC trains contained a mixture of periodic and aperiodic events. Autocorrelation analysis of sIPSC trains showed that a majority of ce
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19

Mujeni, Ruvarashe Chigiya. "Financing Devolution in a COVID-19 Environment: The Status of Devolution in Zimbabwe." Quest Journal of Management and Social Sciences 3, no. 2 (2021): 307–22. http://dx.doi.org/10.3126/qjmss.v3i2.41587.

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Background: The concept of devolution has always presented significant controversy in African unitary states. It is often viewed with inherent suspicion and skepticism based on the lack of mutual trust between the people and the government. While proponents see it as a form of empowerment, resistant groups in society view the decentralization of government powers and responsibilities as a gateway to success. Despite the devolution agenda being a major component of local governance in the Zimbabwean Constitution of 2013, it would not be practically implemented until the new dispensation that ro
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20

Sullivan, Michelle N., and Scott Earley. "TRP channel Ca2+ sparklets: fundamental signals underlying endothelium-dependent hyperpolarization." American Journal of Physiology-Cell Physiology 305, no. 10 (2013): C999—C1008. http://dx.doi.org/10.1152/ajpcell.00273.2013.

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Important functions of the vascular endothelium, including permeability, production of antithrombotic factors, and control of vascular tone, are regulated by changes in intracellular Ca2+. The molecular identities and regulation of Ca2+ influx channels in the endothelium are incompletely understood, in part because of experimental difficulties associated with application of patch-clamp electrophysiology to native endothelial cells. However, advances in confocal and total internal reflection fluorescence microscopy and the development of fast, high-affinity Ca2+-binding fluorophores have recent
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21

Marconi, Gabriel Roberto, Narcis Julien Herlo, Brigitte Osser, Corina Ramona Dulceanu, Denis Petran, and Claudiu Octavian Bulzan. "The Importance Of Selection And The Influence Of An Assisted Training Program On The Development Of Motor Skills In Children A Comparative Study." Arena - Journal of Physical Activities 13 (June 7, 2025): 153–65. https://doi.org/10.62591/ajpa.2025.13.12.

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The multiple aspects related to the importance of selection in the sports field are one of the fundamental requirements and, at the same time, the premises for successful results in the long term. The objectives of this study were to achieve a rigorous selection, adapted to the specifics of athletic events, considering a variety of parameters that, integrated, outline the general sports profile of the children included in the research. The methods used included the initial and final testing of the students remaining in the study group, in order to obtain a more objective and precise assessment
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22

SCHULZHENKO, YURY. "DOMESTIC POLITICAL PARTIES ON THE STATE STRUCTURE OF RUSSIA IN THE PRE-OCTOBER PERIOD." Sociopolitical Sciences 11, no. 1 (2021): 38–44. http://dx.doi.org/10.33693/2223-0092-2021-11-1-38-44.

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The purpose of the research. The choice of this topic is due to the fact that the issues of the state structure of Russia are constantly the subject of close attention of scientists. This is mainly due to the fact that there is a huge practical experience here, when virtually every period of Russian history represented something bright and new. These issues are the subject of close attention not only of domestic, but also of foreign scientists (Emons T., Thatcher I., etc.). The article is devoted to the analysis of the positions of all-Russian, national political parties in our country in the
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23

Gambini, Rodolfo, and Jorge Pullin. "The Montevideo Interpretation: How the Inclusion of a Quantum Gravitational Notion of Time Solves the Measurement Problem." Universe 6, no. 12 (2020): 236. http://dx.doi.org/10.3390/universe6120236.

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We review the Montevideo Interpretation of quantum mechanics, which is based on the use of real clocks to describe physics, using the framework that was recently introduced by Höhn, Smith, and Lock to treat the problem of time in generally covariant systems. These new methods, which solve several problems in the introduction of a notion of time in such systems, do not change the main results of the Montevideo Interpretation. The use of the new formalism makes the construction more general and valid for any system in a quantum generally covariant theory. We find that, as in the original formula
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24

Heni Kiki Daulay, Laila Rohani, and Nabila Yasmin. "Kerajaan Huristak Tahun 1884-1966." JURNAL PENDIDIKAN DAN ILMU SOSIAL (JUPENDIS) 1, no. 4 (2023): 121–36. http://dx.doi.org/10.54066/jupendis.v1i4.885.

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This research was conducted because there are several problems, namely regarding the lack of knowledge of the public and the general public about the Huristak Kingdom especially regarding the historical events that occurred in 1884-1966, the royal heritage at that time and regarding the great contribution of the Huristak Kingdom in terms of fighting for the independence of the Unitary Republic of Indonesia. Indonesia (NKRI) using historical research methods as well as philological and archaeological theories by observing the remains of the Huristak Kingdom such as manuscripts, hairy spears, dr
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25

Harper, Sara, and Anatoli Karypidou. "Moral Suffering in Frontline Social Care Workers: A Study of Moral Injury and Moral Distress." European Journal of Mental Health 19 (2024): 1–18. http://dx.doi.org/10.5708/ejmh.19.2024.0021.

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Introduction: Moral suffering (MS) is psycho-emotional harm derived from a conflict between one’s circumstances and one’s deeply held moral values. It includes the constructs of moral distress (MD) and moral injury (MI) and is characterized by constraints or mandates preventing the perceived morally correct event. Evidence has demonstrated the application of MS in helping professions, and research has linked MS to a deterioration of mental health, self-identity, worldview, and job-performance. Aims: In this study, we examined the relationship between MD, MI, burnout, and external/internal cons
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26

Todd, Robert D., Sarah M. McDavid, Rebecca L. Brindley, Mark L. Jewell, and Kevin P. M. Currie. "Gabapentin Inhibits Catecholamine Release from Adrenal Chromaffin Cells." Anesthesiology 116, no. 5 (2012): 1013–24. http://dx.doi.org/10.1097/aln.0b013e31825153ea.

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Background Gabapentin is most commonly prescribed for chronic pain, but acute perioperative effects, including preemptive analgesia and hemodynamic stabilization, have been reported. Adrenal chromaffin cells are a widely used model to investigate neurosecretion, and adrenal catecholamines play important physiologic roles and contribute to the acute stress response. However, the effects of gabapentin on adrenal catecholamine release have never been tested. Methods Primary cultures of bovine adrenal chromaffin cells were treated with gabapentin or vehicle for 18-24 h. The authors quantified cate
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27

Erkayeva, Shahnoza Quvondiqovna, Saodat Karimovna Rajabova, and Dilnavoz Komilovna Madraximova. "TEACHING SPEECH SKILLS." PEDAGOGS international research journal 2, no. 1 (2022): 83–86. https://doi.org/10.5281/zenodo.5878679.

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The development of oral speech is one of the main practical tasks of teaching a foreign language to secondary school. Graduates of high school should be able to hear and understand foreign language speech. In school experience, there are many problems associated with the teaching of oral speech, despite the fact that oral speech has not taken its proper place for a long time and to some extent has become a means of teaching. In particular, in school conditions, the foreign language was difficult to meet in the acquisition of oral speechchiliklar identified, linguistic and psychological aspects
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28

Zou, Hui, Lawrence M. Lifshitz, Richard A. Tuft, Kevin E. Fogarty, and Joshua J. Singer. "Imaging Ca2+ Entering the Cytoplasm through a Single Opening of a Plasma Membrane Cation Channel." Journal of General Physiology 114, no. 4 (1999): 575–88. http://dx.doi.org/10.1085/jgp.114.4.575.

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Discrete localized fluorescence transients due to openings of a single plasma membrane Ca2+ permeable cation channel were recorded using wide-field digital imaging microscopy with fluo-3 as the Ca2+ indicator. These transients were obtained while simultaneously recording the unitary channel currents using the whole-cell current-recording configuration of the patch-clamp technique. This cation channel in smooth muscle cells is opened by caffeine (Guerrero, A., F.S. Fay, and J.J. Singer. 1994. J. Gen. Physiol. 104:375–394). The localized fluorescence transients appeared to occur at random locati
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29

Shnitser, Ihor. "PROBLEMS OF THE FEDERALIZATION OF CZECHOSLOVAKIA IN JANUARY – AUGUST 1968." Scientific Herald of Uzhhorod University. Series: History, no. 1 (48) (June 11, 2023): 99–105. http://dx.doi.org/10.24144/2523-4498.1(48).2023.280307.

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The article is devoted to studying the preparatory stage of the constitutional reform aimed at the transition of the Czechoslovak Socialist Republic (CSR) from a unitary to a federal state system. The lower chronological limit of the article (January 1968) is dictated by the coming to power in Czechoslovakia of communist reformers who, in the context of the democratization of social and political life, began to search for ways to solve the Slovak question in Czechoslovakia. The upper chronological limit (August 1968) is determined by the beginning of the invasion of the troops of the Warsaw Pa
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30

Bueno de las Heras, Julio L., Antonio Gutiérrez-Lavín, Manuel María Mahamud-López, Marisol Muñiz-Álvarez, and Patricia Rodríguez-López. "Towards a Unified Model on the Description and Design of Process Operations: Extending the concept of Separation Units to Solid-fluid Sedimentation." Recent Innovations in Chemical Engineering (Formerly Recent Patents on Chemical Engineering) 12, no. 1 (2019): 15–53. http://dx.doi.org/10.2174/2405520412666181123094540.

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Background: Bridging the gap between different phenomena, mechanisms and levels of description, different design methods can converge in a unitary way of formulation. This protocol consolidates the analogy and parallelism in the description of any unit operation of separation, as is the particular case of sedimentation. This holistic framework is compatible and complementary with other methodologies handled at length, and tries to contribute to the integration of some imaginative and useful - but marginal, heuristic or rustic- procedures for the design of settlers and thickeners, within well f
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31

Ermakova, E. V. ""LETTER TO THE KING" BY JULES DESTRY: FROM SEPARATISM TO UNITARISM IN BELGIUM." MGIMO Review of International Relations, no. 3(48) (June 28, 2016): 102–11. http://dx.doi.org/10.24833/2071-8160-2016-3-48-102-111.

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Contradictions between the regions of Belgium - Wallonia and Flanders - have a long history associated with uneven political, economic and cultural development of the territories, which in 1830 became parts of an independent state, the Kingdom of Belgium. The "Letter to the King", written by eminent Belgian politician and writer, socialist Jules Destree (1863 - 1936 gg.), is one of the most interesting sources on the history of Belgium of this period, It became a kind of manifesto of balance between the ideas of separatism and unitarianism. This article includes excerpts from the "Letter to th
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32

SOKOLOVA, I. V. "DEVELOPMENT OF SOCIAL QUALITIES OF STUDENTS BY MEANS OF PHYSICAL CULTURE." Physical Culture Sport Tourism Motor Recreation 9, no. 3 (2024): 121–26. https://doi.org/10.47475/2500-0365-2024-9-3-121-126.

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The article examines the influence of physical culture and sports activities on the formation of socially significant qualities in students, by means of a questionnaire it was found that the most significant, from the point of view of students, for the formation of positive social qualities, are sports competitions, meetings with outstanding athletes. Based on the analysis of the literature and processing of the survey results, it is concluded that the correct organization of physical culture and sports activities contributes to the development of positive social qualities, and reduces the imp
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33

Gallamini, Andrea, Monia Marchetti, Anna Borra, Roberto Sorasio, and Francesca Fiore. "Cost-Effectiveness of Interim PET Response Adapted Therapy In ABVD-Treated, Advanced-Stage Hodgkin Lymphoma." Blood 118, no. 21 (2011): 1563. http://dx.doi.org/10.1182/blood.v118.21.1563.1563.

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Abstract Abstract 1563 Background: ABVD chemotherapy (AT) is the standard treatment for patients with advanced-stage Hodgkin lymphoma (HL). However, BEACOPP achieves a higher disease control at a cost of a definitely higher toxicity. Positron emission tomography (PET) after two chemotherapy cycles (PET2) is the most reliable predictor of treatment outcome in ABVD-treated patients. A PET-2 response-adapted strategy with a therapy shift from ABVD to BEACOPP in PET2 positive patients (A/B-T) was shown to increase the 2-y Failure Free Survival (FFS) in the latter from 12% to 62% by indirect retros
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34

Wang, Nien-Shao, Marc Marino, and Roberto Malinow. "Detecting unitary synaptic events with machine learning." Proceedings of the National Academy of Sciences 121, no. 6 (2024). http://dx.doi.org/10.1073/pnas.2315804121.

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Spontaneously occurring miniature excitatory postsynaptic currents (mEPSCs) are fundamental electrophysiological events produced by quantal vesicular transmitter release at synapses. Their analysis can provide important information regarding pre- and postsynaptic function. However, the small signal relative to recording noise requires expertise and considerable time for their identification. Furthermore, many mEPSCs smaller than ~8 pA are not well resolved (e.g., those produced at distant synapses or synapses with few receptor channels). Here, we describe an automated approach to detect mEPSCs
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Rostami, Vahid, Junji Ito, Michael Denker, and Sonja Grün. "[Re] Spike Synchronization and Rate Modulation Differentially Involved in Motor Cortical Function." ReScience 3, no. 1 (2017). https://doi.org/10.5281/zenodo.583814.

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A reference implementation of <strong>Spike synchronization and rate modulation di erentially involved in motor cortical function</strong>. Alexa Riehle, Sonja Grün, Markus Diesmann, and Ad Aertsen (1997) Science 278:1950-1953. DOI:10.1126/science.278.5345.19 50
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Bock, Matthias, Pavel Sekatski, Jean-Daniel Bancal, et al. "Calibration-independent bound on the unitarity of a quantum channel with application to a frequency converter." npj Quantum Information 10, no. 1 (2024). http://dx.doi.org/10.1038/s41534-024-00859-0.

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AbstractWe report on a method to certify a unitary operation with the help of source and measurement apparatuses whose calibration throughout the certification process needs not be trusted. As in the device-independent paradigm our certification method relies on a Bell test and requires no assumption on the underlying Hilbert space dimension, but it removes the need for high detection efficiencies by including the single additional assumption that non-detected events are independent of the measurement settings. The relevance of the proposed method is demonstrated experimentally by bounding the
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Oz, Osnat, Lior Matityahu, Aviv Mizrahi-Kliger, et al. "Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons." eLife 11 (July 11, 2022). http://dx.doi.org/10.7554/elife.76039.

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The tonic activity of striatal cholinergic interneurons (CINs) is modified differentially by their afferent inputs. Although their unitary synaptic currents are identical, in most CINs cortical inputs onto distal dendrites only weakly entrain them, whereas proximal thalamic inputs trigger abrupt pauses in discharge in response to salient external stimuli. To test whether the dendritic expression of the active conductances that drive autonomous discharge contribute to the CINs' capacity to dissociate cortical from thalamic inputs, we used an optogenetics-based method to quantify dendritic excit
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Minello, Giorgia, Andrea Torsello, and Edwin R. Hancock. "Open system quantum thermodynamics of time-varying graphs." Journal of Complex Networks 8, no. 1 (2020). http://dx.doi.org/10.1093/comnet/cnaa004.

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Abstract In this article, we present a novel analysis of time-evolving networks, based on a thermodynamic representation of graph structure. We show how to characterize the evolution of time-varying complex networks by relating major structural changes to thermodynamic phase transitions. In particular, we derive expressions for a number of different thermodynamic quantities (specifically energy, entropy and temperature), which we use to describe the evolutionary behaviour of the network system over time. Since in the real world no system is truly closed and interactions with the environment ar
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Hasyim, Rustam, Faisal Faisal, and Rasti Amalia Faruk. "SULTAN TERNATE ISKANDAR DJABIR SYAH DAN PETUALANGANNYA DALAM NEGARA INDONESIA TIMUR, 1946-1950." Jurnal Geocivic 1, no. 1 (2018). http://dx.doi.org/10.33387/geocivic.v1i1.862.

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This study aims to reconstruct the political participation of Iskandar Djabir Syah (the 47thSultan of Ternate) in the establishment of the State of Eastern Indonesia. The study focuses on outlining some political events involving Iskandar Djabir Syah such as the Malino and Denpasar conferences and becaming the Minister of Home Affairs of the Eastern Indonesia State for 1949 to 1950 periods. The method used in this paper is a heuristic method that is history, criticism, interpretation and historiography. The results showed that: (1) the participation of Sultan of Ternate Iskandar Djabir Syah in
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Grant, Julie B., and Rachel Johnson-Koenke. "Navigating chronic uncertainty: a theory synthesis for nursing communication in life-limiting illness." BMC Nursing 23, no. 1 (2024). http://dx.doi.org/10.1186/s12912-024-02328-7.

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Abstract Background Despite the proven benefits of early palliative care, patient communication regarding these services remains elusive. Therefore, this paper aims to (a) provide a focused literature review on nurse palliative care communication addressing chronic uncertainty in life-limiting illness (LLI), (b) define the Reconceptualization of Uncertainty in illness Theory and Problematic Integration Theory within a nursing Unitary Caring Science philosophical worldview and, (c) synthesize these theories and literature review into a unique theoretical framework for early palliative care comm
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Gascon, Mathieu, and Nadia El-Mabrouk. "On the complexity of non-binary tree reconciliation with endosymbiotic gene transfer." Algorithms for Molecular Biology 18, no. 1 (2023). http://dx.doi.org/10.1186/s13015-023-00231-5.

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AbstractReconciling a non-binary gene tree with a binary species tree can be done efficiently in the absence of horizontal gene transfers, but becomes NP-hard in the presence of gene transfers. Here, we focus on the special case of endosymbiotic gene transfers (EGT), i.e. transfers between the mitochondrial and nuclear genome of the same species. More precisely, given a multifurcated (non-binary) gene tree with leaves labeled 0 or 1 depending on whether the corresponding genes belong to the mitochondrial or nuclear genome of the corresponding species, we investigate the problem of inferring a
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Lewalle, Philippe, Yipei Zhang, and K. Birgitta Whaley. "Optimal Zeno Dragging for Quantum Control: A Shortcut to Zeno with Action-Based Scheduling Optimization." PRX Quantum 5, no. 2 (2024). http://dx.doi.org/10.1103/prxquantum.5.020366.

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The quantum Zeno effect asserts that quantum measurements inhibit simultaneous unitary dynamics when the “collapse” events are sufficiently strong and frequent. This applies in the limit of strong continuous measurement or dissipation. It is possible to implement a dissipative control that is known as “Zeno dragging” by dynamically varying the monitored observable, and hence also the eigenstates, which are attractors under Zeno dynamics. This is similar to adiabatic processes, in that the Zeno-dragging fidelity is highest when the rate of eigenstate change is slow compared to the measurement r
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Chronaki, Anna, Núria Planas, and Petra Svensson Källberg. "Onto/Epistemic Violence and Dialogicality in Translanguaging Practices Across Multilingual Mathematics Classrooms." Teachers College Record: The Voice of Scholarship in Education, June 1, 2022, 016146812211040. http://dx.doi.org/10.1177/01614681221104040.

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Background: The focus on translanguaging practices in multilingual classrooms can be seen, by and large, as responding to risks of violence entailed in diverse contexts of language use, including the teaching and learning of mathematics. However, the practice of translanguaging alone cannot counteract the hegemonic authority of monolingual and monologic curricula being present through interactions among teachers, students, and researchers, as well as material resources. Purpose: Drawing on Bakhtin’s philosophy of language, we discuss dialogicality as a critical and democratic organizing princi
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Beurg, Maryline, Jong-Hoon Nam, and Robert Fettiplace. "The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis." Journal of General Physiology 153, no. 10 (2021). http://dx.doi.org/10.1085/jgp.202112959.

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Although mechanoelectrical transducer (MET) channels have been extensively studied, uncertainty persists about their molecular architecture and single-channel conductance. We made electrical measurements from mouse cochlear outer hair cells (OHCs) to reexamine the MET channel conductance comparing two different methods. Analysis of fluctuations in the macroscopic currents showed that the channel conductance in apical OHCs determined from nonstationary noise analysis was about half that of single-channel events recorded after tip link destruction. We hypothesized that this difference reflects a
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Lowe, Sarah, Rhodri Johnson, Ian Jones, and Sian Morrison-Rees. "Establishment of a National Homelessness Prevention Programme dataset to enable an anonymised longitudinal dynamic cohort based study." International Journal of Population Data Science 3, no. 4 (2018). http://dx.doi.org/10.23889/ijpds.v3i4.905.

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IntroductionWelsh Government invests over £120m annually in housing related support to help prevent and tackle homelessness under the ‘Supporting People Programme’.&#x0D; A 2016 data-linkage Feasibility Study indicated health-service utilisation reductions post-intervention, and led to a four year project to create a national, all-Wales dataset to provide robust statistical results.&#x0D; Objectives and ApproachEstablish data sharing agreements, acquire and import anonymised individual-level data into the SAIL Databank. Create a research ready dataset, designed to permit annual administrative
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Sanna, Antonello, Giuseppina Monni, and Paolo Sanjust. "Carbonia 1937- 41. The Worksite of Autarchic Architecture." Rivista Tema 8, N. 1 (2022) (2022). http://dx.doi.org/10.30682/tema0801n.

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Carbonia is one of the examples of Italian autarchy before the beginning of World War II. Some of the main national construction companies and high-level designers, of which came from the previous experiences of Fascist foundation towns, focused on the new capital of the coal district. Carbonia is the last phase of this experiment, the most important in terms of size and strategic relevance. Carbonia’s urban scene is clearly characterized by two dominant approaches: Pulitzer’s central European modernism, which features the “First Carbonia”, and Montuori’s Mediterranean rationalism, which featu
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ANAK, AGUNG GEDE RAKA, MADE SUWITRA I, AGUNG ISTRI MANIK WARMADEWI ANAK, M.F.G.B. XIMENES PEDRO, and XAVIER JUVIANO. "COMMODIFICATION OF LOCAL WISDOM IN THE GLOBAL TOURISM ERA: COMPARATIVE STUDY OF PARADOX CASES OF UTILIZATION OF BALINESE LOCAL WISDOM WITH TIMOR-LESTE." 17, no. 12 (2022): 233–50. https://doi.org/10.5281/zenodo.7421464.

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<strong>Abstract</strong> Bali and Timor Leste have the same vision for developing their country, namely to make tourism one of the sources of foreign exchange income for the country. As is known, the two parties&rsquo; experiences in managing tourism are very different. On the one hand, Bali has recovered since the new normal in May 2022. On the other hand, Timor Leste has only started its tourism activities since breaking away from the Unitary State of the Republic of Indonesia in 2002 and is recovering. Bali is used to managing various tourism activities on a global scale. To be precise, Ba
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El Faham, Hesham, Fabio Maltoni, Ken Mimasu, and Marco Zaro. "Single top production in association with a WZ pair at the LHC in the SMEFT." Journal of High Energy Physics 2022, no. 1 (2022). http://dx.doi.org/10.1007/jhep01(2022)100.

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Abstract We study single top quark production in association with a WZ pair at the LHC in the context of the Standard Model (SM) and the Standard Model Effective Field Theory (SMEFT). A significant advantage of tWZ compared to other EW top production processes is its sensitivity to unitarity-violating behaviour induced in its 2 → 2 sub-amplitudes through modified EW interactions. At NLO in QCD, tWZ interferes with t$$ \overline{t} $$ t ¯ Z and t$$ \overline{t} $$ t ¯ and a method to meaningfully separate it from these overlapping processes needs to be employed. In order to define tWZ productio
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Cavanagh, Jerald, Mihaela Banek Zorica, Sandra Kučina Softić, and Marko Odak. "DIGITOOLS - the future of open digital education." PUBMET, October 10, 2022, 87. http://dx.doi.org/10.15291/pubmet.3958.

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The Multiplier Events will see the participation of stakeholders, international experts, and academia. The aim of this regional multiplier event is to bring the results of the research conducted within the DIGITOOLS project. The workshop will also discuss the future of digital education in universities and European frameworks in the field of digital education. Special focus is on the role of Universities in the effective implementation of digital learning, Open educational resources and open access to resources.The crisis generated by the COVID 19 pandemic has forced European universities to m
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Carlos-Rivera, Fernando, Jorge Antonio Guzmán-Caniupan, Luis Miguel Camacho-Cordero, Therese Aubry de Maraumont, and Noe Soria-Suárez. "Estimated frequency and economic burden of incident fragility fractures during 2023 in Mexico." Archives of Osteoporosis 19, no. 1 (2024). http://dx.doi.org/10.1007/s11657-024-01468-2.

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Abstract Summary Epidemiologic and economic data regarding osteoporotic fractures in Mexico is scarce and mostly outdated. Through a model, we estimated the incidence and costs of osteoporotic fractures in adults ≥ 50 years old in Mexico during the year 2023. Results showed that these events are both frequent and costly, leading to a considerable economic impact. Purpose Osteoporosis and its fractures impose a high clinical and economic burden. The objective of this analysis was to estimate the frequency and costs owing to incident fragility fractures (FFs) during the year 2023 in Mexico. Meth
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