To see the other types of publications on this topic, follow the link: United States. Navy. Medical Department.
Journal articles on the topic 'United States. Navy. Medical Department'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'United States. Navy. Medical Department.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Ulcickas Yood, Marianne, Susan Jick, Catherine Vasilakis-Scaramozza, Bonnie M. K. Donato, Ioannis Tomazos, Gilbert L'Italien, Nicholas Sicignano, and Brian L. Feldman. "Baseline Characteristics of Patients with Paroxysmal Nocturnal Hemoglobinuria Identified in the Department of Defense Database." Blood 132, Supplement 1 (November 29, 2018): 5830. http://dx.doi.org/10.1182/blood-2018-99-113478.
Full textAbstract:
Abstract Background: Rare diseases are often characterized by misdiagnosis resulting in delays in critical and potentially lifesaving treatment. Awareness of first signs and symptoms of rare diseases can provide clinical evidence for early and accurate diagnosis. Medical records are the primary source of clinical information from first signs and symptoms to key clinical disease related events, yet access to records can be difficult and time consuming. We conducted a study using a large electronic medical record (EMR) and claims database to identify and describe characteristics of Paroxysmal Nocturnal Hemoglobinuria (PNH) patients at the time of their PNH diagnosis. We present baseline findings of the PNH population identified in the Department of Defense (DOD) healthcare system, where all clinical details were readily available. The DOD healthcare system is a US-based, longitudinal EMR and claims database with health information on approximately 10 million active beneficiaries throughout the country. Methods: We identified all people in the DOD database from January 01, 2007 through May 31, 2017 who had an ICD-10-CM code for PNH or a NDC or HCPCS code for eculizumab, the drug used to treat PNH. There is no ICD-9-CM code for PNH. Cases had no other indication for eculizumab use and had to have appropriate symptoms, comorbidities or lab results to be considered a case. We reviewed the electronic record for each patient and classified each as definite/likely, probable/possible or unlikely PNH based on attributes of the available health data including codes for eculizumab, flow cytometry, lab results, hemoglobinuria, aplastic anemia, pancytopenia and other comorbidities. Our ruling was validated by medical record review by a clinical expert for all equivocal cases and a sample of definite/likely cases. Individuals classified as unlikely PNH were excluded. Patient characteristics at PNH diagnosis are presented using descriptive statistics. Results: We identified 73 PNH patients (55% female) after review of all available electronic data; 41 had a diagnosis of PNH and received eculizumab, 17 had a diagnosis of PNH only, and 15 received eculizumab only. From these, 61 patients were determined to have definite/likely PNH and 12 had probable/possible PNH. The use of eculizumab ranged from 0 to 378 (median=18) prescriptions, dependent in part on the amount of follow-up in the database. There were 19 patients (26%) who had prevalent PNH and 54 (74%) who were newly diagnosed with PNH during the study period. Among newly diagnosed patients, the median age at PNH diagnosis was 46 years (range 13 - 86). Most patients had codes for hemoglobinuria at or before the PNH diagnosis date (69%), and many had codes for aplastic anemia (46%), thrombocytopenia (56%), and pancytopenia (28%). At any time after the PNH diagnosis, 85% had unspecified anemia, 52% had aplastic anemia, 53% had thrombocytopenia, and 33% had pancytopenia codes in their records. See table. Conclusion: From a population of around 10 million actively enrolled patients, across a 10-year study period, we identified 73 patients with PNH. Data from these patients will be used to identify patterns of health encounters leading up to diagnosis and relevant outcomes following diagnosis. This information can be used to help diagnose other patients with this rare disease and to improve their medical outcomes. Disclaimer Statement: Research data were derived from an approved Naval Medical Center, Portsmouth, VA IRB protocol (NMCP.2017.0080). The views expressed in this abstract are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense or the United States Government. Copyright Notice: CAPT Brian Feldman is a military service member. This work was prepared as part of his official duties. Title 17 U.S.C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U.S.C. 101 defines a United States Government work as a work prepared by a military service member or employee of the United States Government as part of that person's official duties. Table. Table. Disclosures Ulcickas Yood: Alexion Pharmaceuticals, Inc.: Other: Employee of EpiSource, LLC, which was contracted by Alexion Pharmaceuticals, Inc. EpiSource had the final decision on content. . Jick:Alexion Pharmaceuticals, Inc.: Other: Employee of the Boston Collaborative Drug Surveillance Program, which was contracted and paid by Alexion Pharmaceuticals, Inc. to work on a study of PNH using DOD data. . Vasilakis-Scaramozza:Alexion Pharmaceuticals, Inc.: Other: Employee of the Boston Collaborative Drug Surveillance Program, which was contracted and paid by Alexion Pharmaceuticals, Inc. to work on a study of PNH using DOD data.. Donato:Alexion Pharmaceuticals Inc: Employment, Equity Ownership. Tomazos:Alexion Pharmaceuticals, Inc.: Employment, Equity Ownership. L'Italien:Alexion Pharmaceuticals, Inc.: Equity Ownership, Other: Former employee and current stockholder of Alexion Pharmaceuticals, Inc. . Sicignano:Alexion Pharmaceuticals, Inc.: Other: Employee of Health ResearchTx, which has a business relationship with Alexion Pharmaceuticals, Inc.. Feldman:Alexion Pharmaceuticals, Inc.: Other: Employee, Department of Navy, United States Government..
2
Ulcickas Yood, Marianne, Susan Jick, Catherine Vasilakis-Scaramozza, Bonnie M. K. Donato, Ioannis Tomazos, Gilbert L'Italien, Nicholas Sicignano, and Brian L. Feldman. "The Value of Population Based Data to Study Rare Diseases: An Example Using the Department of Defense Healthcare System." Blood 132, Supplement 1 (November 29, 2018): 5829. http://dx.doi.org/10.1182/blood-2018-99-113497.
Full textAbstract:
Abstract Background: For patients suffering from rare diseases, accurate and early diagnosis is critical and often lifesaving, whereas misdiagnosis can be fatal. While patient registries are useful and necessary, they may not provide reliable patient population denominators or sufficient longitudinal clinical follow-up. Access to complete and integrated patient records necessary to capture full clinical history can be challenging. Commonly, there is a lack of centralized and continuous care in the health care systems of many countries, including the United States (US). It is also challenging to identify a sufficient number of cases to provide robust results because of the rare nature of these diseases. We describe a healthcare system that can identify patients for research purposes, who have rare diseases, by accessing de-identified electronic clinical details. We used Paroxysmal Nocturnal Hemoglobinuria (PNH) as an example of a rare disease for this abstract. Methods: The Department of Defense (DOD) healthcare system is a US-based, longitudinal electronic health record (EHR) and claims database with health information on approximately 10 million active beneficiaries across the country. We evaluated the feasibility to conduct studies of rare diseases in the DOD healthcare system by assessing the capability to identify patients with PNH and to describe their course of disease and treatment. We used ICD 9/10 diagnosis codes, NDC and HCPCS codes, laboratory data and PNH treatment codes to identify patients with a clinical course consistent with PNH. Patients were classified as definite/likely, probable/possible or unlikely PNH based on the available clinical evidence and then findings were validated against review of patient records by a clinical expert. Individuals classified as unlikely PNH were excluded from the study. The clinical information on these patients will be used to understand the course of PNH in patients with and without treatments and to describe their treatment adherence and disease activity over time. Results: We identified 244 people with a diagnosis or treatment code that was indicative of PNH during years 2007-2017; 71% of the patients had electronic records that covered 10 or more years starting as early as 2003 and extending as far as 2017. From these 244 patients, we identified 73 patients with a definite/likely or probable/ possible PNH diagnosis. An ICD-10 code for PNH or a prescription for eculizumab (PNH treatment) were required, but not sufficient to confirm the presence of PNH. There is no ICD-9 code for PNH. Cases had no other indication for eculizumab use and had to have appropriate symptoms, comorbidities or lab results to be considered a case. Patients with only 1 code for PNH and no treatment were assumed to have unconfirmed disease and were excluded. 27 cases, including those with no eculizumab and a random sample of likely cases, were reviewed to validate the PNH diagnoses in collaboration with DOD treating physicians. Conclusion: The DOD healthcare system is a valuable and cost effective resource for the study of rare diseases in a timely manner. We have demonstrated the ability to identify a validated series of PNH cases that will provide important clinical insights for identifying and treating new PNH cases. This healthcare system provides long patient follow-up, demographics similar to the US population, and access to records in an integrated inpatient, outpatient and ER system that encompasses all patient care. Disclaimer Statement: Research data were derived from an approved Naval Medical Center, Portsmouth, VA IRB protocol (NMCP.2017.0080). The views expressed in this abstract are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense or the United States Government. Copyright Notice: CAPT Brian Feldman is a military service member. This work was prepared as part of his official duties. Title 17 U.S.C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U.S.C. 101 defines a United States Government work as a work prepared by a military service member or employee of the United States Government as part of that person's official duties. Disclosures Ulcickas Yood: Alexion Pharmaceuticals, Inc.: Other: Employee of EpiSource, LLC, which was contracted by Alexion Pharmaceuticals, Inc. EpiSource had the final decision on content. . Jick:Alexion Pharmaceuticals, Inc.: Other: Employee of the Boston Collaborative Drug Surveillance Program, which was contracted and paid by Alexion Pharmaceuticals, Inc. to work on a study of PNH using DOD data. . Vasilakis-Scaramozza:Alexion Pharmaceuticals, Inc.: Other: Employee of the Boston Collaborative Drug Surveillance Program, which was contracted and paid by Alexion Pharmaceuticals, Inc. to work on a study of PNH using DOD data.. Donato:Alexion Pharmaceuticals Inc: Employment, Equity Ownership. Tomazos:Alexion Pharmaceuticals, Inc.: Employment, Equity Ownership. L'Italien:Alexion Pharmaceuticals, Inc.: Equity Ownership, Other: Former employee and current stockholder of Alexion Pharmaceuticals, Inc. . Sicignano:Alexion Pharmaceuticals, Inc.: Other: Employee of Health ResearchTx, which has a business relationship with Alexion Pharmaceuticals, Inc.. Feldman:Alexion Pharmaceuticals, Inc.: Other: Employee, Department of Navy, United States Government..
3
Hickman, Jonathan, and Joseph An. "Kikuchi-Fujimoto Disease: A Case Report." Blood 138, Supplement 1 (November 5, 2021): 4189. http://dx.doi.org/10.1182/blood-2021-152440.
Full textAbstract:
Abstract Kikuchi-Fujimoto: A Case Report Hickman, JD. MD LT MC USN and An, Joseph, DO. LCDR MC USN Naval Medical Center Portsmouth 620 Johns Paul John Cir, Portsmouth VA 757-953-2223 The views expressed in this abstract are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the United States Government. We are military service members and employees of the U.S. Government. This work was prepared as part of my official duties. Title 17 U.S.C. 105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. 101 defines a United States Government work as a work prepared by a military service member or employee of the United States Government as part of that person's official duties. Kikuchi-Fujimoto disease is a rare benign disorder often presenting with tender cervical lymphadenopathy, fever, and malaise. While first described in Japan, its distribution is worldwide and predominantly seen in young adults. Diagnosis is based on characteristic histopathologic findings of patchy necrosis occupied by karyorrhectic debris and abundant histiocytes on node biopsy. The origin is unclear but associated with a preceding viral illness as well as cutaneous lupus erythematosus. Treatment is generally supportive and focused on managing tender lymph nodes. We present a case of a 28-year-old female presenting with a 2 month history of night sweats, fever, and weight loss in the setting of painful neck swelling. CT and PET/CT imaging demonstrated numerous hypermetabolic and enlarged nodes in the bilateral cervical and axillary regions. Lab studies were notable for leukopenia, anemia, and elevated inflammatory markers. A COVID-19 screening was negative. Excisional biopsy of a cervical node revealed extensive cortical necrosis and apoptotic debris with scattered histiocytes and plasmacytoid dendritic cells in absence of neutrophils or a monoclonal B cell or T cell population. Treatment was initiated with NSAIDs and close monitoring. The patient exhibited a complete response after two months. Our case is an important reminder that lymphadenopathy, fever, and night sweats in a young adult are not pathognomonic for lymphoma. Nonetheless, a high suspicion for lymphoma should be maintained and followed with an expedited workup. Kikuchi-Fujimoto can certainly mimic Hodgkin lymphoma or other serious conditions like lupus erythematosus and tuberculosis. The diagnosis is largely one of exclusion following a careful examination of a lymph node histopathology and must be considered in young previously healthy adults to avoid misdiagnosis and unnecessary escalation of treatment. Disclosures No relevant conflicts of interest to declare.
4
Summers, Shane M., Christopher J. Nagy, Michael D. April, Brandon W. Kuiper, Rechell G. Rodriguez, and Woodson S. Jones. "The Prevalence of Faculty Physician Burnout in Military Graduate Medical Education Training Programs: A Cross-Sectional Study of Academic Physicians in the United States Department of Defense." Military Medicine 184, no. 9-10 (April 3, 2019): e522-e530. http://dx.doi.org/10.1093/milmed/usz055.
Full textAbstract:
Abstract Introduction In military populations, physician burnout has potential to adversely affect medical readiness to deploy in support of joint operations. Burnout among Graduate Medical Education (GME) faculty may further threaten the welfare of the medical force given the central role these officers have in training and developing junior physicians. The primary aim of this investigation was to estimate the prevalence of burnout among faculty physicians in United States (US) Army, Navy, and Air Force GME programs. Materials and Methods We conducted a cross-sectional study of faculty physicians at US military GME training programs between January 2018 and July 2018. Through direct coordination with Designated Institutional Officials, we administered the Maslach Burnout Inventory Health Services Survey (MBI-HSS) via online web link to faculty physicians listed in Accreditation Data System at each sponsoring institution. In addition to the MBI-HSS, we collected demographic data and queried physicians about common occupational stressors in order to assist institutional leaders with identifying at-risk physicians and developing future interventions to address burnout. Results Sixteen of 21 institutions that currently sponsor military GME programs agreed to distribute the MBI-HSS survey to core faculty. We received completed assessments from 622 of the 1,769 (35.1%) reported physician core faculty at these institutions. Of the 622 physician respondents, 162 demonstrated high levels of emotional exhaustion and depersonalization for an estimated 26% prevalence of burnout. We identified only one independent risk factor for burnout: increasing numbers of deployments (OR 1.38, 95% CI 1.07–1.77). Physicians in our cohort who reported a desire to stay beyond their initial active duty service obligation were less likely to be classified with burnout (OR 0.45, 95% CI 0.26–0.77). The most common drivers of occupational distress were cumbersome bureaucratic tasks, insufficient administrative support, and overemphasis on productivity metrics. Conclusions We estimate that 26% of physician faculty in military GME programs are experiencing burnout. No specialty, branch of service, or specific demographic was immune to burnout in our sample. Institutional leaders in the MHS should take action to address physician burnout and consider using our prevalence estimate to assess effectiveness of future interventions.
5
Eggleston, Heather, Nina Shoemaker, Christina Gariepy, Julie Norton, Kelsey Beauman, Aaron Kim, Christine Fedorchuk, James Roberts, Frederic Poly, and Renee Laird. "Immunopathogenesis of Campylobacter jejuniinfection in a small animal model." Journal of Immunology 210, no. 1_Supplement (May 1, 2023): 82.17. http://dx.doi.org/10.4049/jimmunol.210.supp.82.17.
Full textAbstract:
Abstract We set out to develop and characterize a small animal model of Campylobacter jejuni(CJ) infection that recapitulates human campylobacteriosis. Adult C57BL/6J mice are rendered susceptible to colonization and disease by pre-treatment with a zinc deficient diet and a broad-spectrum antibiotic cocktail. We have established this model with four strains with diverse capsular serotypes and flagellar groups, two key virulence factors for CJ pathogenesis. We measured colonization, weight loss, diarrhea, fecal inflammatory markers, and cytokine production by mesenteric lymphocytes and splenocytes. Diarrhea containing visible mucous and/or blood and degree of weight loss vary in severity depending on the strain and dose. Interestingly, we identified an inverse relationship between inoculum dose and levels of fecal inflammatory markers, with lower inoculum doses inducing significantly higher inflammation. We also observed production of IFNγ and IL-17 at day 9 post infection and despite no decrease in CJ colonization, IFNγ and IL-17 levels decreased by day 21 with a subsequent increase in IL-10 production. We also observed higher levels of IFNγ and IL-17 in mice challenged with strain CG8486 relative to those challenged with strain 81–176 pointing to potential strain differences. These differences observed were more striking in mesenteric lymphocytes versus splenocytes, indicating that local cellular responses differed from systemic responses. We have developed a model of inflammatory diarrhea in adult mice that exhibits hallmarks of CJ infection and further identified significant shifts in cytokine expression associated with the duration of infection, bacterial strain utilized, and therapeutic treatment. Research reported in this presentation is supported by Navy work unit number: 6000.RAD1.DA3.A0308 and CARB-X. CARB-X’s funding for this project is sponsored by the Cooperative Agreement Number IDSEP160030 from ASPR/BARDA and by awards from Wellcome Trust, the UK Global Antimicrobial Resistance Innovation Fund (GAMRIF) funded by the UK Government Department of Health and Social Care (DHSC) and the Bill & Melinda Gates Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of CARB-X or any of its funders. Disclaimers: The views expressed in this work are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. F. Poly is an employee of the U.S. Government. This work was prepared as part of official duties. Title 17 U.S.C. §105 provides that ‘Copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. §101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person’s official duties.The animal study protocol was reviewed and approved by the Naval Medical Research Center IACUC in compliance with all applicable Federal regulations governing the protection of animals in research.
6
Bauer, Elizabeth M., and Thanh Duc Hoang. "Complete Androgen Insensitivity and Decreased Bone Mineral Density." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A778—A779. http://dx.doi.org/10.1210/jendso/bvab048.1584.
Full textAbstract:
Abstract Background: Complete androgen insensitivity syndrome (CAIS) is a rare disorder of sex development and primary amenorrhea results in an XY karyotype but female phenotype. Patients with this syndrome have lower bone mineral density (BMD) when compared to age matched controls. Clinical Case: A 44-year-old phenotypic woman with a history of complete androgen insensitivity syndrome presented for follow-up. She was previously on hormone replacement therapy (HRT) at various doses from the age of 12 until her early 30s when her therapy became sporadic. At age 40, she was prescribed transdermal estrogen therapy but discontinued soon after a dermatologic reaction and had not been on any form of hormone replacement since that time. Past medical history was significant for karyotype 46 XY, osteochondritis dissecans of right ankle and bilateral orchiectomy at age 4. She was single with one adopted child. Physical examination showed a height 75 inches, weight 244 lbs and a normal heart, lung, and abdominal examinations. Laboratory results showed estradiol 12.3pg/mL(7.63-42.6), total testosterone 12.0 ng/dL(7-40), FSH 109.6 mIU/mL(25.8-134.8), LH 42.49 mIU/mL(7.7-58.5), anti-mullerian hormone < 0.015 ng/mL (0.26-5.81), inhibin B <7.0 pg/mL(<17), androstenedione 48 ng/dL(41-262), dihydrotestosterone 2.7 ng/dL(4-22) and dehydroepiandrosterone sulfate 209 ng/dL(31-701). A baseline DXA showed low bone density for age with T-score (Z-score) of -2.0 (-1.6) lumbar-spine; -1.6 (-1.2) femoral neck, -1.1 (-0.8) total hip and -2.5 (-2.0) forearm. Discussion:CAIS is caused by a mutation in the androgen receptor (AR) located on the X-chromosome causing complete unresponsiveness to androgen hormone. Karyotype is XY but feminization occurs due to aromatization of androgen to estrogen. Gonadectomy for testicular malignancy prevention is controversial as testicular tumors in CAIS is generally low and gonadal resection subjects individuals to lifelong hormone replacement. These patients also have lower BMD when compared to female or male age matched controls. This is even more apparent in those with removed gonads. Low BMD is exacerbated by poor compliance, inadequate dose or inappropriate HRT. Whether or not fracture risk is higher has yet to be elucidated. Currently, there is no guideline on how to manage low BMD including osteoporosis in this patient population. It is important to counsel patients with CAIS on BMD loss and to ensure optimization of factors that affect bone health including compliance with HRT, vitamin D/calcium intake and exercise. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or the United States Government.
7
Selvanesan, Benson, Sheelu Varghese, Justyna Andrys, Ricardo Arriaza, Rahul Prakash, Purushottam Tiwari, Cara Olsen, et al. "Abstract P2-17-04: Pharmacological inhibition of LY6K induced cell cycle arrest and DNA damage by disrupting the LY6K-Histone-Aurora B signaling axis." Cancer Research 83, no. 5_Supplement (March 1, 2023): P2–17–04—P2–17–04. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-17-04.
Full textAbstract:
Abstract Pharmacological inhibition of LY6K induced cell cycle arrest and DNA damage by disrupting the LY6K-Histone-Aurora B signaling axis Benson C. Selvanesan1,2, Sheelu Varghese1,2, Justyna Andrys5, Ricardo H. Arriaza6, Rahul Prakash6, Purushottam B Tiwari7, Cara Olsen8, Daniel Hupalo2,4, Yuriy Gusev5, Megha N. Patel6, Sara Contente1, Miloslav Sanda9, Aykut Uren7, Matthew D. Wilkerson3,4, Clifton L. Dalgard3,4, Linda S. Shimizu6, Maksymilian Chruszcz6, Tomasz Borowski5, Geeta Upadhyay 1,3,7. Affiliations 1 Department of Pathology, 2 Henry M. Jackson Foundation, 3 Murtha Cancer Center, 4 Department of Anatomy, Physiology, and Genetics 8 Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 5 Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Cracow, Poland. 6 Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA. 7 Department of Oncology, Georgetown University Medical Center, Washington, DC, USA. 9 Max Planck Institute for Heart and Lung Research, Ludwigstrasse, 43, 61231 Bad Nauheim, Germany. Correspond Disclaimer The opinions expressed herein are those of the authors and are not necessarily representative of the official policies of the Uniformed Services University of the Health Sciences (USUHS), the Department of Defense (DOD), the United States Army/Navy/Air Force, the U.S. Government, or any other funding agencies Conflict of Interest None Acknowledgments NIH, NCI, R01 CA227694. NIH, NCI, R21CA256424. DOD, USUHS, VPR-NFP-74-9824. Biomedical Instrumentation Center, USUHS. The American Genome Center, USUHS. Antibody Characterization Program, Clinical Proteomics Tumor Analysis Consortium (CPTAC), National Cancer Institute, National Institute of Health. The Polish Grid Infrastructure, Cracow, Poland. NIH P30CA51008 and 1S10OD019982-01 to Biacore Molecular Interaction Shared Resource (BMISR), Georgetown University. ABSTRACT Increased expression of LY6K is significantly associated with poor survival outcomes in many solid cancers, including triple-negative and estrogen receptor-positive breast, ovarian, gastric, head and neck, neuroblastoma, bladder, and lung cancers. Inhibition of LY6K signaling is an ideal therapeutic approach for cancer, since the LY6K protein is not involved in vital organ function. Previously, we identified the small molecule NSC243928 as a binder of LY6K using surface plasmon resonance screening and showed that its activity was dependent on LY6K expression in triple-negative breast cancer cells. Here, we demonstrate the structural basis of the molecular interaction of NSC243928 with LY6K protein and the subsequent inhibition of LY6K function in mitosis and cell division via Aurora B-histone pathway. We observed that LY6K interacts with phosphorylated histones and Aurora B kinases during mitosis and that this interaction was disrupted in the presence of NSC243928. Disruption of LY6K function in mitosis/cytokinesis leads to DNA damage, senescence, and apoptosis of cancer cells. We observed that NSC243928 led to increased binding of LY6K to phosphorylated gammaH2X at S139, which was dependent on NSC243928 interaction with LY6K on phenylalanine 79. Furthermore, we observed increased levels of phosphorylated gammaH2X at S139 and increased caspase-3 activation in the tumor isografts of 4T1 and E0771 mammary tumors treated with NSC243928. These data reveal that LY6K is a novel cell cycle target for therapeutic development in triple-negative breast cancer and other solid cancers with high expression of LY6K, such as bladder cancer, head and neck, and lung cancer. Citation Format: Benson Selvanesan, Sheelu Varghese, Justyna Andrys, Ricardo Arriaza, Rahul Prakash, Purushottam Tiwari, Cara Olsen, Daniel Huplo, yuriy Gusev, Megha Patel, Sara Contente, Miloslav Sanda, Matthew Wilkerson, Clifton Dalgard, Linda S. Shimizu, Maksymilian Chruszcz, Tomasz Borowski, Geeta Upadhyay. Pharmacological inhibition of LY6K induced cell cycle arrest and DNA damage by disrupting the LY6K-Histone-Aurora B signaling axis [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P2-17-04.
8
Long, Glenn, Gareth Jones, David Roper, Yasmin Eaton, and Amy Howells. "The Royal Navy Operating Department Practitioner: Perioperative care on land and sea." Journal of Perioperative Practice 30, no. 6 (September 16, 2019): 176–82. http://dx.doi.org/10.1177/1750458919864826.
Full textAbstract:
Royal Navy Operating Department Practitioners are employed in a number of different roles, during peacetime, humanitarian aid operations and periods of war. In recent times, Royal Navy Operating Department Practitioners have deployed on active operations in addition to working in NHS hospitals at home in the United Kingdom. This article will explore the different avenues and experiences of Operating Department Practitioners who are currently serving in the Royal Navy. The reader will then also gain an insight into the different echelons of care provided by the Defence Medical Services to the United Kingdom Armed Forces and Allied Nations. The article will then consider the unique experiences available to Royal Navy Operating Department Practitioners in this multi-faceted role which offers the opportunity to explore work patterns in different environments.
9
Gough, Barry M. "American sealers, the United States Navy, and the Falklands 1830–32." Polar Record 28, no. 166 (July 1992): 219–28. http://dx.doi.org/10.1017/s0032247400020684.
Full textAbstract:
ABSTRACTBy the early 1830s, American sealers expected free access to the waters and harbours of the Falkland Islands, an active rule over which had not been recognized by the United States. The US government, in the form of President Andrew Jackson and the State Department, adhered to a policy of freedom of the seas, and therefore backed the rights of American sealers to unrestricted access in the South Atlantic. After three sealing ships were impounded by the Argentinian authorities in the Falklands in 1831, the US Navy sloop Lexington, under the command of Captain Silas Duncan, destroyed the island group's capital at Puerto Soledad, and, with it, the Argentine military defences. The State Department informed the Argentine govermcnt that it had no claims, historic or actual, to the Falklands. The American policy of not recognizing the Argentine claims, which continued for half a century, did not interfere with British designs. In 1832–33 the British government issued orders for the Admiralty to send a warship to re-establish British control of the Falklands.
10
Reneker, Maxine H., and Joan L. Buntzen. "Enterprise knowledge portals: two projects in the United States Department of the Navy." Electronic Library 18, no. 6 (December 2000): 392–403. http://dx.doi.org/10.1108/eum0000000005386.
Full text
11
Cozzetto, Don. "The Officer Fitness Report as a Performance Appraisal Tool." Public Personnel Management 19, no. 3 (September 1990): 235–44. http://dx.doi.org/10.1177/009102609001900301.
Full textAbstract:
Performance evaluation is an important tool for effective management. Much of the recent literature has focused on the efficacy of civilian performance appraisal systems. As a result, there is a knowledge gap with respect to military appraisal systems in general, and those of the United States Navy and the United States Marine Corps in particular. The 1978 Civil Service Reform Act spawned several performance appraisal systems within each of these agencies; the USMC utilizes five separate systems in the evaluation of civilian and military personnel; the Navy has adopted three separate appraisal mechanisms. This article specifically examines the device used to evaluate senior military staff in the Navy and Marine Corps—the fitness report. Because this particular appraisal methodology differs radically from its federal civilian counterparts, a rather detailed descriptive section serves as an orientation for the reader. The approach is intended to supplement John Pelissero's article on performance evaluation in the Department of the Army (Pelissero, 1984).
12
Bennett, Brad L., David P. Gray, and David A. Wynkoop. "The United States Navy Medical Service Corps: The Golden Anniversary 1947–1997." Military Medicine 162, no. 8 (August 1, 1997): 513–14. http://dx.doi.org/10.1093/milmed/162.8.513.
Full text
13
Downing, Micah, Jonathan Gillis, Ben Manning, Josh Mellon, and Matthew Calton. "Navy aircraft sound monitoring study." INTER-NOISE and NOISE-CON Congress and Conference Proceedings 264, no. 1 (June 24, 2022): 775–86. http://dx.doi.org/10.3397/nc-2022-809.
Full textAbstract:
The United States Department of the Navy (Navy), as directed by Congress, executed a real time sound monitoring study of jet aircraft at Naval Air Station (NAS) Whidbey Island and NAS Lemoore over the past year and compared the resulting measured data with modeled noise data. The Navy collected real-time aircraft sound level and operational data during four discrete seven-day monitoring periods in 2020 and 2021. The data collected each period included: (1) acoustic recordings by sound level meters deployed at sites around each airfield to capture sound levels during a range of flight operations across a range of seasonal weather conditions; and (2) detailed operations data. The collected acoustic data are compared to noise modeling done specifically for this study using the observed flight operations data. This presentation provides and overview of the measured data and the results of the comparison with modeled data.
14
Shattuck, Nita, and Panagiotis Matsangas. "0213 Sleep and well-being of culinary specialists on United States Navy ships." SLEEP 46, Supplement_1 (May 1, 2023): A94. http://dx.doi.org/10.1093/sleep/zsad077.0213.
Full textAbstract:
Abstract Introduction In the US Navy, “galley workers” are those sailors involved in cooking and preparing meals and maintaining the overall cleanliness and hygiene of the galley spaces and messdecks. These sailors begin their workday in the ship’s kitchen in the early morning, working until late in the evening, typically sleeping at night. The purpose of the current study was to assess the fatigue levels, work/rest patterns, health-related behaviors, and well-being of galley workers on US Navy ships while underway. Methods In this longitudinal field assessment, 80 fit-for-duty US Navy galley workers performed their normal duties on 11 surface ships. Participants wore actigraphs, and completed activity logs and questionnaires to include four standardized tools (Pittsburgh Sleep Quality Index – PSQI; Epworth Sleepiness Scale – ESS; Insomnia Severity Index – ISI; Profile of Mood States – POMS). Results Galley workers had a median age of 25 (IQR=11.8) years and most of them were male (68, 85.0%). Most galley workers reported drinking caffeinated beverages (60, 80.0%), with nicotine or tobacco products used by 22 (29.3%) participants. In terms of working out, 46 (61.3%) reported having an exercise routine. The typical schedule of the galley workers included sleeping at night with work hours extending from around 6:00 AM till 8:00 PM. Specifically, they slept on average 6.57±0.85 hours/day (~29% slept < 6 hours/day) and worked 12.8±2.43 hours/day (25% worked >14.5 hours/day). Approximately 84% were classified as poor sleepers, ~57% had excessive daytime sleepiness, and ~38% had elevated insomnia symptoms. Compared to adult norms for the POMS total and subscales scores, the mood of galley workers was worse in terms of total mood disturbance (84.1%), tension-anxiety (71.4%), anger-hostility (79.4%), vigor-activity (77.8%), fatigue (68.3%), and confusion-bewilderment (73.0%). Conclusion Galley workers on USN ships are chronically sleep-deprived and work long hours. To ameliorate the detrimental effects of these issues on sailor well-being, leaders should consider adopting strategies to improve sailor well-being. For example, appropriately timed short naps during the day, use of caffeine, and exposure to bright light may be viable methods to incorporate into the daily schedule of galley workers to alleviate the effects of their arduous work schedules. Support (if any)
15
Shattuck, N. L., and P. Matsangas. "0776 Differences in Well-Being in Dayworkers Compared to Shift Workers: A Study of United States Navy Sailors." Sleep 43, Supplement_1 (April 2020): A295. http://dx.doi.org/10.1093/sleep/zsaa056.772.
Full textAbstract:
Abstract Introduction On United States Navy (USN) ships, most sailors are shift workers, required to support 24/7 operations. However, ~15% of the ship’s company are solely dayworkers who do not work in shifts. It is often assumed that the quality of life for dayworkers is better than that of shift workers. This study compared the well-being of dayworkers with that of shift workers. Methods Longitudinal, naturalistic observations were made of sailors (N=926; 18-59 years of age, ~80% males, ~84% enlisted personnel) on seven US Navy ships while performing their normal underway duties. Sleep-related attributes (actigraphy, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Insomnia Severity Index), mood (Profile of Mood States), and work/rest patterns were assessed. Results Dayworkers (DW; n=98) were on average older (p=0.001) and more senior (p=0.001) than shift workers (SW). Of the dayworkers, 31% reported elevated daytime sleepiness (SW:45.5%; p=0.008), 64.2% were poor sleepers (SW:82.6%; p<0.001), and 26.3% had ISI score≥15 (SW:24.8%; p=0.782). Also, 13.8% of the dayworkers had ESS>10 and ISI≥15 (SW:16.8%; p=0.626).Dayworkers had better mood (Total Mood Disturbance, anger/hostility, vigor, fatigue; all p<0.050), slept more (7.03±0.74hrs sleep/day; SW:6.52±1.03hrs; p<0.001) and had more consolidated sleep (1.1±0.3 sleep episodes/day; SW:1.4±0.6; p<0.001). Yet, split sleep was commonplace for both groups (DW:~62%; SW:~92%).The two groups do not differ (all p>0.300) in their use of caffeinated beverages (82%-86%), use of nicotine products (30%-36%), or having a regular exercise routine (69%-75%). In both groups, ~9% of sailors drank caffeinated beverages, used nicotine products and did not have an exercise routine (p=0.999). Dayworkers worked 10.1 hours/day, i.e., 1.7 hours/day less than watchstanders (p<0.001). Conclusion Quality of life of dayworkers is a bit better when compared to shift workers, but sleep-related issues are evident in almost all US Navy sailors. Living and working on a naval vessel takes a toll on almost everyone aboard. A culture change is required! Support Supported by the Naval Medical Research Center’s Advanced Medical Development Program, the US Navy 21st Century Sailor Office, and the US Navy OPNAV N1.
16
Hood, Charles Hardin. "The United States Army Medical Department in Low-Intensity Conflict." Military Medicine 156, no. 2 (February 1, 1991): 64–67. http://dx.doi.org/10.1093/milmed/156.2.64.
Full text
17
Shattuck, N. L., and P. Matsangas. "0821 Gender Differences in Sailor Well-Being, Sleep-Related Behaviors, and Psychomotor Vigilance Performance in the United States Navy." Sleep 43, Supplement_1 (April 2020): A313. http://dx.doi.org/10.1093/sleep/zsaa056.817.
Full textAbstract:
Abstract Introduction Approximately 18% of US Navy sailors are females. Research has shown gender-related differences in the prevalence of sleep disorders in active duty personnel (Foster et al., 2017). Specifically, insomnia, depression, and anxiety are more prevalent in females, while obstructive sleep apnea is more prevalent in males. We have studied the sleep patterns and fatigue levels of crew members on more than 30 US Navy ships. The current study focuses on gender differences in well-being, sleep-related behaviors, and psychomotor vigilance performance of sailors in the US Navy. Methods Using a longitudinal, naturalistic observation paradigm, data were collected from crewmembers on nine USN ships while performing their normal underway duties. Participants (N=1,056) tended to be young (on average 27 years of age), predominantly male (80.6%), and enlisted (84.8%). We assessed average daytime alertness (Epworth Sleepiness Scale), insomnia symptoms (Insomnia Severity Index), mood (Profile of Mood States), and sleep quality (Pittsburgh Sleep Quality Index). Sleep was assessed with actigraphy and logbooks. Sailors performed a 3-minute version of the Psychomotor Vigilance Task (PVT), which was built into their wrist-worn actigraph. Results Compared to males, female sailors reported more depressive symptoms (p=0.042) and less vigor (p<0.001). Females slept more (daily sleep duration: p<0.001) but their sleep was split into more episodes than their male counterparts (p=0.029). Fewer females reported a regular exercise routine (p=0.033). In addition, females report consuming fewer energy drinks (p=0.007), and using fewer nicotine products (p=0.013). Lastly, consistent with findings from civilian populations, female sailors had slower reaction times on the PVT (p<0.001) and experienced more lapses combined with false starts (p<0.001) than their male counterparts. Conclusion Compared to their male peers, female sailors tend to report higher levels of depression and lower levels of vigor. They experience more pronounced split sleep, are less likely to report having an exercise routine, and have poorer performance on the PVT. Fewer females report using energy drinks and nicotine products. Support This research was supported by the Naval Medical Research Center’s Advanced Medical Development Program, the US Navy 21st Century Sailor Office, and the US Navy OPNAV N1.
18
Starsman, Jessica, Ashley Adamczak, and Tom DeRuyter. "Alaskan North Slope Legacy Wells: Case Study." International Oil Spill Conference Proceedings 2014, no. 1 (May 1, 2014): 697–710. http://dx.doi.org/10.7901/2169-3358-2014.1.697.
Full textAbstract:
ABSTRACT Various State of Alaska agencies, including the Alaska Department of Environmental Conservation (ADEC), are currently investigating 136 legacy wells within the National Petroleum Reserve-Alaska (NPR-A) and surrounding lands. These legacy wells were drilled between 1944 and 1981 by federal agencies, including the United States Navy and United States Geological Survey, to explore oil reserve potential and to develop drilling techniques for Alaska's arctic. In 2004, 2010 and 2013 the Bureau of Land Management released preliminary studies describing potential environmental risks at each site. Many wells include historic reserve pits, flare pits, crude and diesel oil releases, and discarded solid waste. Tundra damage and potential residual contamination are of great concern. Due to their remote locations, information on the current status of waste is limited. Regulatory agencies are developing a cleanup plan that is appropriate for their remote, Arctic environment.
19
Vold Pepper, Patricia, and Douglas K. Owens. "Cost-Effectiveness of the Pneumococcal Vaccine in the United States Navy and Marine Corps." Clinical Infectious Diseases 30, no. 1 (January 2000): 157–64. http://dx.doi.org/10.1086/313601.
Full text
20
Muller, John G., W. Garry Rudolph, Jonathan M. Lieske, Jose E. Hernandez, Moore H. Jan, and Gosia Kubiak. "Changes in B-Readings Over Time in the United States Navy Asbestos Medical Surveillance Program." Journal of Occupational and Environmental Medicine 49, no. 2 (February 2007): 194–203. http://dx.doi.org/10.1097/jom.0b013e31802df12c.
Full text
21
Willy, Mary, Judith P. Kelly, Parivash Nourjah, David W. Kaufman, Daniel S. Budnitz, and Judy Staffa. "Emergency department visits attributed to selected analgesics, United States, 2004-2005." Pharmacoepidemiology and Drug Safety 18, no. 3 (December 30, 2008): 188–95. http://dx.doi.org/10.1002/pds.1691.
Full text
22
Newmark, Jonathan. "Military Bands as a Population for Studying Musicians' Health." Medical Problems of Performing Artists 24, no. 1 (March 1, 2009): 50. http://dx.doi.org/10.21091/mppa.2009.1011.
Full textAbstract:
The largest employer of full-time musicians in the United States is the Department of Defense. There are, within the Department, four separate full-time band programs (Army, Air Force, Marines, and Navy), of which the Army is by far the largest. Not only are these musicians employed full-time, but they have completely free health care and a uniform, electronic, world-wide health record that follows them for the length of their careers. They also have to adhere to the physical fitness standards of their services, including both height and weight standards and biannual physical fitness tests; in the Army, the latter includes pushups, sit-ups, and 2-mile runs every 6 months. It has always occurred to me that this population is uniquely suited to the sort of study that the Editorial in the September 2009 issue describes.
23
Cope, Stanton E., Georgia NW Schoeler, and Gregory M. Beavers. "Medical Entomology in the United States Department of Defense: Challenging and Rewarding." Outlooks on Pest Management 22, no. 3 (June 1, 2011): 129–33. http://dx.doi.org/10.1564/22jun09.
Full text
24
McAlister, W. Howard, Jeffrey L. Weaver, Jerry D. Davis, and Jeffrey A. Newsom. "Military Optometry from World War I to the Present." Hindsight: Journal of Optometry History 52, no. 1 (July 21, 2021): 4–8. http://dx.doi.org/10.14434/hindsight.v51i3.31044.
Full textAbstract:
Optometry has made significant contributions to the United States military for over a century. Assuring good vision and eye health of soldiers, sailors, airmen and marines is critical to maximizing the military functions necessary to achieve victory. There was little organization or recognition of the profession in World War I, but optometrists were essential in achieving the mission. Recognition of the profession of optometry was still limited in World War II but it was improving, especially with commissioning as officers occurring in the Navy. Through the Korean and Vietnam Wars, optometry grew in stature and strength with all services eventually commissioning all optometrists, and Army optometrists were assigned to combat divisions. Continuing through the more recent conflicts in the middle east, the profession has continued to make an impact and has become an essential part of the armed forces of the United States. Doctors of optometry are now an integral part of the Department of Defense. The nation cannot field an effective fighting force today without the dedicated performance of these officers.
25
Thomas, R. J., D. E. Conwill, D. E. Morton, T. J. Brooks, C. K. Holmes, and W. B. Mahaffey. "Penicillin Prophylaxis for Streptococcal Infections in United States Navy and Marine Corps Recruit Camps, 1951-1985." Clinical Infectious Diseases 10, no. 1 (January 1, 1988): 125–30. http://dx.doi.org/10.1093/clinids/10.1.125.
Full text
26
Lall, Rakesh, Vijay K. Jain, and W. Brad Johnson. "Contemporary Norms for the Coopersmith Self-Esteem Inventory-Adult Form." Perceptual and Motor Skills 82, no. 3_suppl (June 1996): 1136–38. http://dx.doi.org/10.2466/pms.1996.82.3c.1136.
Full textAbstract:
422 medical personnel employed by the United States Navy were administered the Adult Form of the Coopersmith Self-esteem Inventory. In comparison to Coopersmith's 1981 normative sample, the current sample was substantially larger, geographically heterogeneous, and more reflective of the current national population. Analysis suggests small but consistent increases in mean self-esteem scores across all subgroups. Nonetheless, data from the current study are quite consistent with the findings from Coopersmith's 1981 normative sample.
27
Galarneau, Michael R., Susan I. Woodruff, Judy L. Dye, Charlene R. Mohrle, and Amber L. Wade. "Traumatic brain injury during Operation Iraqi Freedom: findings from the United States Navy–Marine Corps Combat Trauma Registry." Journal of Neurosurgery 108, no. 5 (May 2008): 950–57. http://dx.doi.org/10.3171/jns/2008/108/5/0950.
Full textAbstract:
Object The purpose of this study was to characterize traumatic brain injuries (TBIs) among military personnel (primarily Marines) during the second phase of Operation Iraqi Freedom from early in the medical care chain of evacuation through Landstuhl Regional Medical Center, a Level 4 American hospital in Germany. Methods Data were obtained from the Navy–Marine Corps Combat Trauma Registry (CTR) and included both battle and nonbattle injuries. Follow-up of patients with TBI was conducted to examine the short-term medical and personnel-related effects of TBI among those surviving. Results Those injured in battle were more likely than those not injured in battle to have multiple TBI diagnoses, a greater number of all diagnoses, more severe TBIs, and to be medically evacuated. Intracranial injuries (for example, concussions) were the predominant type of TBI, although skull fractures and open head wounds were also seen. Improvised explosive devices were the most common cause of TBIs among battle injuries; blunt trauma and motor vehicle crashes were the most common causes among nonbattle injuries. Short-term follow-up of surviving patients with TBI indicated higher morbidity and medical utilization among the patients with more severe TBI, although mental conditions were higher among patients with milder TBI. Conclusions Data from the Navy–Marine Corps CTR provide useful information about combatants' TBIs identified early in the combat casualty process. Results may improve clinical care for those affected and suggest strategies for primary prevention. The CTR staff plans to conduct additional follow-up studies of this group of patients with TBI.
28
Lewis Shattuck, Nita, and Matsangas Panagiotis. "Crew endurance training in the united states navy: Lessons learned from senior leadership, prospective commanding/executive officers, and department heads." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 65, no. 1 (September 2021): 1470–74. http://dx.doi.org/10.1177/1071181321651076.
Full textAbstract:
The Crew Endurance Team at the Naval Postgraduate School led a 3-year project to develop and deliver crew endurance and sleep hygiene training to support the US Navy’s implementation of circadian-based watchbills. As part of this effort, 16 training sessions were delivered to 362 active-duty service members (ADSMs) of the USN, including senior Navy leaders (n=249), prospective commandingIexecutive officers (PCOIPXOs) (n=30) at the Surface Warfare Officers School (SWOS) and students (n=83) attending SWOS Department Head School. Overall, responses from all audiences were positive indicating a high level of satisfaction with the training. We identified the need to expand two parts of the training: stimulants and sleep-promoting medications, and tips for sleeping in military environments. We will continue to tailor the training to the specific needs of ADSMs. We continue to train military audiences to increase awareness of the critical importance of sleep for operational performance and resilience.
29
Lindroth, Erica J., Mark S. Breidenbaugh, and Jeffrey D. Stancil. "US Department of Defense Support of Civilian Vector Control Operations Following Natural Disasters." Journal of the American Mosquito Control Association 36, no. 2s (June 1, 2020): 82–89. http://dx.doi.org/10.2987/19-6884.1.
Full textAbstract:
ABSTRACT The United States Department of Defense (DoD) employs advanced-degreed entomologists as Preventive Medicine and Public Health Officers in the Army, Navy, and Air Force. While the primary objective of military entomologists is service member health and readiness (“force health protection”), military entomology resources can provide support to civil authorities as directed by the President or Secretary of Defense through Department of Defense Directive 3025.18, Defense Support of Civil Authorities (DSCA). The employment of DSCA is complex and involves the consideration of such factors as the proper request process, funding, legality, risk, appropriateness, and readiness. Once approved and mobilized, however, military preventive medicine assets can be of significant help to civil authorities when dealing with emergency vector control. This paper will address some of the policy issues surrounding the use of DSCA, outline the resources available from the individual military services, and provide examples of DoD contingency vector control support to civil authorities.
30
Shehane, Richard, Steve Miller, Luke Suber, and Miranda Chakos. "Treatment of Acute Psychosis with Second-Generation Antipsychotics in a Patient with Left Temporal Lobe Lesion." Case Reports in Psychiatry 2018 (2018): 1–3. http://dx.doi.org/10.1155/2018/9839252.
Full textAbstract:
We present a case of rapid onset severe psychosis followed by suicide attempt in a United States Navy sailor. Investigation revealed a left temporal lobe brain mass suspicious for low-grade glioma. After hospitalization and medical management with olanzapine and lurasidone the patient’s psychosis improved. The purpose of this paper is to add to the existing case reports that suggest a relationship between temporal lobe lesions and psychiatric illness, specifically psychosis. In addition, this case adds insight into the effectiveness of medical therapy for brain tumor patients that are not immediate candidates for neurosurgical intervention.
31
Johnson, Tricia J., Jaymie S. Youngquist, Andy N. Garman, Samuel Hohmann, and Paola R. Cieslak. "Factors influencing medical travel into the United States." International Journal of Pharmaceutical and Healthcare Marketing 9, no. 2 (June 1, 2015): 118–35. http://dx.doi.org/10.1108/ijphm-02-2013-0004.
Full textAbstract:
Purpose – This paper aims to evaluate the potential of 24 country-level measures for predicting the number of outbound international medical travelers into the USA, including health and healthcare system, economic, social and diplomatic and travel pattern factors. Medical travel is recognized as a growing global market and is an important subject of inquiry for US academic medical centers, hospitals and policy makers. Few data-driven studies exist to shed light on efficient and effective strategies for attracting international medical travelers. Design/methodology/approach – This was a retrospective, cross-sectional study of the 194 member and/or observer countries of the United Nations. Data for medical traveler volume into the USA between 2008 and 2010 were obtained from the USA Department of Commerce, Office of Travel and Tourism Industries, Survey of International Air Travelers. Data on country-level factors were collected from publicly available databases, including the United Nations, World Bank and World Health Organization. Linear regression models with a negative binomial distribution and log link function were fit to test the association between each independent variable and the number of inbound medical travelers to the USA. Findings – Seven of the 24 country-level factors were significantly associated with the number of outbound medical travelers to the USA These factors included imports as a per cent of gross domestic product, trade in services as a per cent of gross domestic product, per cent of population living in urban areas, life expectancy, childhood mortality, incidence of tuberculosis and prevalence of human immunodeficiency virus. Practical implications – Results of this model provide evidence for a data-driven approach to strategic outreach and business development for hospitals and policy makers for attracting international patients to the USA for medical care. Originality/value – The model developed in this paper can assist US hospitals in promoting their services to international patients as well as national efforts in identifying “high potential” medical travel markets. Other countries could also adapt this methodology for targeting the international patient market.
32
Goldstein, JN, CA Camargo, AJ Pelletier, and JA Edlow. "Headache in United States Emergency Departments." Cephalalgia 26, no. 6 (June 2006): 684–90. http://dx.doi.org/10.1111/j.1468-2982.2006.01093.x.
Full textAbstract:
Headache is a common complaint in the emergency department (ED). In order to examine headache work-ups and diagnoses across the USA, we queried a representative sample of adult ED visits (the National Hospital Ambulatory Medical Care Survey) for the years 1992–2001. Headache accounted for 2.1 million ED visits per year (2.2% of visits). Of the 14% of patients who underwent neuroimaging, 5.5% received a pathological diagnosis. Of the 2% of patients who underwent lumbar puncture, 11% received a pathological diagnosis. On multivariable analysis, a decreased rate of imaging was noted for patients without private insurance [odds ratio (OR) 0.61, confidence interval (CI) 0.44, 0.86] and for those presenting off-hours (OR 0.55, CI 0.39, 0.77). Patients over 50 were more likely to receive a pathological diagnosis (OR 3.3, CI 1.2, 9.3). In conclusion, clinicians should ensure that appropriate work-ups are performed regardless of presentation time or insurance status, and be vigilant in the evaluation of older patients.
33
Bates, G. William, and Dawn W. Blackhurst. "Leadership qualities of obstetrics and gynecology department chairmen of United States medical schools." American Journal of Obstetrics and Gynecology 166, no. 4 (April 1992): 1102–16. http://dx.doi.org/10.1016/s0002-9378(11)90642-5.
Full text
34
Matsangas, Panagiotis, Nita Shattuck, and Heather Clifton. "289 Rack curtains improve sailors’ sleeping conditions in berthing compartments of the United States Navy (USN) ships." Sleep 44, Supplement_2 (May 1, 2021): A116. http://dx.doi.org/10.1093/sleep/zsab072.288.
Full textAbstract:
Abstract Introduction Ambient light is one of the primary factors affecting sailor sleep in berthing compartments on USN ships. Each “rack” (i.e., bunk) has a curtain, however, intended only for privacy. Current rack curtain specifications do not address light-blocking properties. We assessed the effects of replacing existing, standard rack curtains with enhanced rack curtains that provide superior light-blocking in the sleeping environment. Methods Longitudinal (~2 weeks), naturalistic observation of sailors (N=52; 41 enlisted personnel) on a USN destroyer during deployment. The standard curtain was used for one week followed by one week with the enhanced light-blocking curtain. Sleep-related attributes (Epworth Sleepiness Scale–ESS, Insomnia Severity Index–ISI, Pittsburgh Sleep Quality Index–PSQI) were assessed at the end of each week. Actigraphy and rack temperature data (both inside and outside the rack) were collected throughout the study. Results are presented as median±median absolute deviation. Results Participants slept on average 6.8±1.0 hours/day. ESS scores improved with decreases from 9.0±3.0 with standard curtains to 7.0±3.0 with the enhanced curtains (p=0.020). Sailors with normal daytime sleepiness improved from 33 (63.5%) with standard curtains to 40 (76.9%) with the enhanced curtains. ISI scores decreased from 11.0±3.0 to 8.0±2.0 in the two conditions (p<0.001). The number of Sailors with ISI scores ≥15 decreased from 11 (21.2%) with standard curtains to 8 (13.5%) with the enhanced curtains (p=0.103). PSQI scores (8.0±2.0), however, did not change between the control and the intervention periods (p=0.527). Preliminary analysis showed that, compared to outside the rack, temperature inside the rack was slightly warmer on average with new curtains (~1 °F; p=0.096). Conclusion Our results suggest that the enhanced curtains reduced average daytime sleepiness and severity of insomnia symptoms. A greater difference in rack temperature with the enhanced curtains was observed; however, this may be attributed to the ship sailing in southern latitudes during the intervention period. Ongoing analysis will provide more insight on the utility of the enhanced curtains and their efficacy in improving sleeping conditions. Support (if any) Supported by the Naval Medical Research Center’s Advanced Medical Development Program, the US Navy 21st Century Sailor Office, and the US Navy OPNAV N1.
35
Kumar, Sai, and Vikram Mittal. "Analysis of Cyber Security Methodologies: A Direct Comparison of Current Versus Possible DoD Cyber Assets." Industrial and Systems Engineering Review 6, no. 2 (March 7, 2019): 101–8. http://dx.doi.org/10.37266/iser.2018v6i2.pp101-108.
Full textAbstract:
Recent years and modern warfare have shown an increasing reliance on the cyber domain to maintain national and military operability, resulting in cyber exploits having a more profound impact on victim nations. As the United States seeks to maximize its ability to capitalize on these exploits and minimize its susceptibility, a decision must be made on the most effective way to accomplish these tasks. Currently, each major department within the Department of Defense (DoD) are methodically building up their own cyber assets to accomplish these tasks as they relate to their traditional domain. There has been a recent proposal to do away with this system structure and instead create a separate Cyber Department, on the same level as the Army, Navy, etc. This paper evaluates the comparative value between the two proposals through value modeling. The value model is based on each alternative’s ability to achieve the end state cyber goals of the DoD and the nation as a whole. Strong indicators point towards a separate Cyber Department as the most valuable alternative available to achieve the nation’s goals, and that there are current weaknesses within our current cyber structure that are open for exploitation.
36
Kedia, Sita, Adit A. Ginde, Joseph A. Grubenhoff, Allison Kempe, Andrew D. Hershey, and Scott W. Powers. "Monthly variation of United States pediatric headache emergency department visits." Cephalalgia 34, no. 6 (December 11, 2013): 473–78. http://dx.doi.org/10.1177/0333102413515346.
Full textAbstract:
Objective The objective of this article is to determine the monthly variation of emergency department (ED) visits for pediatric headache. We hypothesized youth have increased headache-related ED visits in the months associated with school attendance. Methods Using a United States representative sample of ED visits in the National Hospital Ambulatory Medical Care Survey from 1997 to 2009, we estimated number of visits associated with ICD-9 codes related to headache, migraine, status migrainosus, or tension-type headache in 5- to 18-year-olds. Age-stratified multivariate models are presented for month of visit (July as reference). Results There was a national estimate of 250,000 ED visits annually related to headache (2.1% of total visits) in 5- to 18-year-olds. In 5- to 11-year-olds, the adjusted rate of headache-related visits was lower in April (OR 0.42, 95% CI 0.20, 0.88). In 12- to 18-year-olds, there were higher rates in January (OR 1.92, 95% CI 1.16, 3.14) and September (OR 1.64, 95% CI 1.06, 2.55). Conclusions In adolescents we found higher ED utilization in January and September, the same months associated with school return from vacation for a majority of children nationally. No significant reduction in the summer suggests that school itself is not the issue, but rather changes in daily lifestyle and transitions.
37
Markle, Stephen P., Sean E. Gill, and Peter S. McGraw. "The U.S. Navy Afloat Solid Waste Management Challenge." Marine Technology and SNAME News 37, no. 04 (October 1, 2000): 200–215. http://dx.doi.org/10.5957/mt1.2000.37.4.200.
Full textAbstract:
The U.S Navy has developed and implemented a comprehensive Solid Waste Management Program to comply with "Act to Prevent Pollution from Ships" (Title 33 United States Code Chapter 33), as amended, which ratified "International Convention for the Prevention of Pollution from Ships" (MARPOL 73/78). Through this program, the U.S. Navy is backfitting its surface fleet with plastic waste processors, pulpers, and shredders to manage nonhazardous solid waste by 31 December 2000. Future Navy ship designs are building upon the lessons learned from the fleet modernization process and are pushing technology to achieve the Chief of Naval Operations, Director Environmental Protection, Safety and Occupational Health (CNO N45) vision for the environmentally sound ship of the 21st century. Evolutionary development of waste transport systems and thermal destruction technologies are essential for realizing this vision. This paper provides an overview of the program and a glimpse of future expectations for management of solid waste through the Navy Integrated Waste Management System. The cornerstone of this system is a compact Plasma Arc Waste Destruction System capable of destroying solid waste, liquid waste, oily waste, and medical waste.
38
Limkakeng Jr, Alexander, Pratik Manandhar, Alaatin Erkanli, Stephanie Eucker, Adam Root, and Deepak Voora. "United States Emergency Department Use of Medications with Pharmacogenetic Recommendations." Western Journal of Emergency Medicine 22, no. 6 (September 23, 2021): 1347–54. http://dx.doi.org/10.5811/westjem.2021.5.51248.
Full textAbstract:
Introduction: Emergency departments (ED) use many medications with a range of therapeutic efficacy and potential significant side effects, and many medications have dosage adjustment recommendations based on the patient’s specific genotype. How frequently medications with such pharmaco-genetic recommendations are used in United States (US) EDs has not been studied. Methods: We conducted a cross-sectional analysis of the 2010–2015 National Hospital Ambulatory Medical Care Survey (NHAMCS). We reported the proportion of ED visits in which at least one medication with Clinical Pharmacogenetics Implementation Consortium (CPIC) recommendation of Level A or B evidence was ordered. Secondary comparisons included distributions and 95% confidence intervals of age, gender, race/ethnicity, ED disposition, geographical region, immediacy, and insurance status between all ED visits and those involving a CPIC medication. Results: From 165,155 entries representing 805,726,000 US ED visits in the 2010–2015 NHAMCS, 148,243,000 ED visits (18.4%) led to orders of CPIC medications. The most common CPIC medication was tramadol (6.3%). Visits involving CPIC medications had higher proportions of patients who were female, had private insurance and self-pay, and were discharged from the ED. They also involved lower proportions of patients with Medicare and Medicaid. Conclusion: Almost one fifth of US ED visits involve a medication with a pharmacogenetic recommendation that may impact the efficacy and toxicity for individual patients. While direct application of genotyping is still in development, it is important for emergency care providers to understand and support this technology given its potential to improve individualized, patient- centered care.
39
Matthews, J. J. "Increasing Role 2 Afloat capability on the Bay Class platforms – lessons from Exercise AZRAQ SERPENT 2018." Journal of The Royal Naval Medical Service 104, no. 3 (2018): 165–68. http://dx.doi.org/10.1136/jrnms-104-165.
Full textAbstract:
AbstractA recent medical proof of concept exercise (Exercise AZRAQ SERPENT 2018) allowed the opportunity for a United States Navy Surgical Team to deploy onto one of the Bay Class platforms (RFA CARDIGAN BAY). This team was utilised in a serial during the exercise to establish a secondary operating position within the medical complex. This showed that the standard Role 2 Afloat team deployed to Bay Class platforms could be supplemented by an additional small surgical team to increase the capability offered and allow a third patient to be treated concurrently. The lessons from this exercise are discussed.
40
Clark, William D., John C. Moskop, and Theodore W. Whitley. "The National (United States) Disaster Medical System: A Survey and Analysis." Prehospital and Disaster Medicine 6, no. 1 (March 1991): 35–39. http://dx.doi.org/10.1017/s1049023x00028041.
Full textAbstract:
AbstractThe National Disaster Medical System (NDMS) was formulated to provide medical care for casualties of future large-scale natural disasters and military conflicts. We sent questionnaires to the 59 emergency medical directors of North Carolina's participating hospitals in order to assess their views regarding the need for NDMS and the level of their hospital's preparedness. Responses were received from 78% (46) of the physicians surveyed. Of those responding, an overwhelming majority supported the need for a national plan like NDMS to treat casualties of a natural disaster or an overseas military conflict. Respondents also agreed that the participation of emergency department personnel, other physicians, and support personnel is essential for successful activation of NDMS. Responses to questions regarding level of preparedness, however, suggested that there is less than an optimal degree of preparedness for participation in NDMS.
41
Unalp-Arida, Aynur, and Constance E. Ruhl. "Burden of gallstone disease in the United States population: Prepandemic rates and trends." World Journal of Gastrointestinal Surgery 16, no. 4 (April 27, 2024): 1130–48. http://dx.doi.org/10.4240/wjgs.v16.i4.1130.
Full textAbstract:
BACKGROUND Gallstone disease is one of the most common digestive disorders in the United States and leads to significant morbidity, mortality, and health care utilization. AIM To expand on earlier findings and investigate prepandemic rates and trends in the gallstone disease burden in the United States using national survey and claims databases. METHODS The National Ambulatory Medical Care Survey, National Inpatient Sample, Nationwide Emergency Department Sample, Nationwide Ambulatory Surgery Sample, Vital Statistics of the United States, Optum Clinformatics® Data Mart, and Centers for Medicare and Medicaid Services Medicare 5% Sample and Medicaid files were used to estimate claims-based prevalence, medical care including cholecystectomy, and mortality with a primary or other gallstone diagnosis. Rates were age-adjusted (for national databases) and shown per 100000 population. RESULTS Gallstone disease prevalence ( claims-based, 2019) was 0.70% among commercial insurance enrollees, 1.03% among Medicaid beneficiaries, and 2.09% among Medicare beneficiaries and rose over the previous decade. Recently, in the United States population, gallstone disease contributed to approximately 2.2 million ambulatory care visits, 1.2 million emergency department visits, 625000 hospital discharges, and 2000 deaths annually. Women had higher medical care rates with a gallstone disease diagnosis, but mortality rates were higher among men. Hispanics had higher ambulatory care visit and hospital discharge rates compared with Whites, but not mortality rates. Blacks had lower ambulatory care visit and mortality rates, but similar hospital discharge rates compared with whites. During the study period, ambulatory care and emergency department visit rates with a gallstone disease diagnosis rose, while hospital discharge and mortality rates declined. Among commercial insurance enrollees, rates were higher compared with national data for ambulatory care visits and hospitalizations, but lower for emergency department visits. Cholecystectomies performed in the United States included 605000 ambulatory laparoscopic, 280000 inpatient laparoscopic, and 49000 inpatient open procedures annually. Among commercial insurance enrollees, rates were higher compared with national data for laparoscopic procedures. CONCLUSION The gallstone disease burden in the United States is substantial and increasing, particularly among women, Hispanics, and older adults with laparoscopic cholecystectomy as the mainstay treatment. Current practice patterns should be monitored for better health care access.
42
Sormanti, Mary, and Erica Smith. "Intimate Partner Violence Screening in the Emergency Department: U.S. Medical Residents' Perspectives." International Quarterly of Community Health Education 30, no. 1 (March 26, 2010): 21–40. http://dx.doi.org/10.2190/iq.30.1.c.
Full textAbstract:
Intimate Partner Violence (IPV) is physical, psychological, or sexual harm committed by a current or former partner, spouse, boy/girlfriend. In the United States, the National Center for Injury Prevention and Control (2003) estimates that 1.5 million women experience physical assault each year while the lifetime prevalence rate of IPV for women reaches almost 30%. Given the frequency and range of injuries and other health-related problems that result from IPV, the medical system shows promise as a central source of service provision for large numbers of abused women and their children. However, identification rates of IPV in many medical settings are low. This article describes a study that examined focus group data from 25 physicians in residency training at an urban hospital in the United States. Physicians discussed their knowledge and attitudes about IPV screening in the emergency department (ED) setting and suggestions to address perceived barriers to such screening. These data depict multiple barriers to physician screening of IPV in the ED. Findings substantiate previous research and provide new direction for enhancing IPV identification, referral, and treatment mechanisms in the ED setting including alternatives to physician mandated universal screening.
43
Bonnington, Samantha, Neil Banham, Kevin Foley, and Ian Gawthrope. "Oxygen toxicity seizures during United States Navy Treatment Table 6: An acceptable risk in monoplace chambers?" Diving and Hyperbaric Medicine Journal 51, no. 2 (June 30, 2021): 167–72. http://dx.doi.org/10.28920/dhm51.2.167-172.
Full textAbstract:
Introduction: Hyperbaric oxygen treatment (HBOT) may be complicated by oxygen toxicity seizures, which typically occur with hyperbaric partial pressures of oxygen exceeding 203 kPa (2 atmospheres absolute). All other hyperbaric units in Australia exclusively use a multiplace chamber when treating with United States Navy Treatment Table 6 (USN TT6) due to this perceived risk. The purpose of this study was to determine the safety of a monoplace chamber when treating decompression illness (DCI) with USN TT6. Methods: A retrospective review of the medical records of all patients treated at Fiona Stanley Hospital Hyperbaric Medicine Unit with USN TT6 between November 2014 and June 2020 was undertaken. These data were combined with previous results from studies performed at our hyperbaric unit at Fremantle Hospital from 1989 to 2014, creating a data set covering a 30-year period. Results: One thousand treatments with USN TT6 were performed between 1989 and 2020; 331 in a monoplace chamber and 669 in a multiplace chamber. Four seizures occurred: a rate of 0.59% (1/167) in a multiplace chamber; and none in a monoplace chamber, indicating no statistically significant difference between seizures in a monoplace versus multiplace chamber (P = 0.31). Conclusions: The rate of oxygen toxicity seizures in a monoplace chamber is not significantly higher than for treatment in the multiplace chamber. We conclude that using the monoplace chamber for USN TT6 in selected patients poses an acceptably low seizure risk.
44
Manthripragada, Angelika D., Esther H. Zhou, Daniel S. Budnitz, Maribeth C. Lovegrove, and Mary E. Willy. "Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States." Pharmacoepidemiology and Drug Safety 20, no. 8 (February 3, 2011): 819–26. http://dx.doi.org/10.1002/pds.2090.
Full text
45
Stephen Martinr and Martin Uribe. "THE INFLUENCE OF REWARD SYSTEM ON EMPLOYEE JOB SATISFACTION WITH WORK MOTIVATION AS INTERVENING VARIABLES (Case Study on Employees of Medical Department United States)." MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation 2, no. 2 (June 30, 2021): 53–71. http://dx.doi.org/10.59733/medalion.v2i2.25.
Full textAbstract:
This study aims to determine“The Influence of the Reward System on Employee Job Satisfaction with Work Motivation as an Intervening Variable (Case Study of Employees of Medical Department United States)
46
Grott, Catherine J. "The Development of the U.S. Health Care System and the Contemporary Role of the Public Health Department." Journal of Health and Human Services Administration 29, no. 3 (September 2006): 336–59. http://dx.doi.org/10.1177/107937390602900303.
Full textAbstract:
The absence of national health care reform and the growing number of uninsured individuals in the United States have prompted states to develop plans to provide medical care for the low income and the indigent. Many local health departments are not only responsible for the core public health functions; but they are increasingly called upon to provide person health care services for those who cannot afford it. This article chronicles the development of the health care system in the United States and describes the contemporary role of the local public health department.
47
Fluke, Laura M., Ryan D. Restrepo, Howard I. Pryor, James E. Duncan, and Kevan E. Mann. "The Surgical Experience aboard USNS COMFORT (T-AH-20) during Operation Continuing Promise 2015." American Surgeon 84, no. 8 (August 2018): 1307–11. http://dx.doi.org/10.1177/000313481808400842.
Full textAbstract:
In 2015, the United States Navy hospital ship (USNS) COMFORT, deployed to 11 Caribbean and Latin American countries over a six-month period to provide humanitarian civic assistance. Personnel from the United States Navy and multiple nongovernmental organizations collaborated to offer surgical and medical care. Data from past deployments aid in planning for future missions by prioritizing finite resources and maximizing care. The data analyzed included all patients evaluated and treated by the Directorate of Surgical Services of the USNS COMFORT between April and September 2015. Comparative and descriptive statistics were performed to analyze patient demographics, surgical subspecialty performing the procedures, types of general and pediatric surgical procedures performed, operative times, and complication rates. Of the 1256 surgical cases performed aboard USNS COMFORT during CP15, 24.8 per cent were general surgery cases, followed by 16 per cent ophthalmology, 10.6 per cent pediatric surgery, 10 per cent plastic surgery, and eight additional specialties with <10 per cent of the cases each. Total operative time was 1253 hours with a total room time of 1896.5 hours. The identified complication rate was 1.99 per cent across all specialties. The USNS COMFORT platform offers the unique capability to provide humanitarian surgical assistance. Reporting these data demonstrate that there is a need for humanitarian assistance and this can be provided safely through the Continuing Promise mission. Future deployments may target resources toward the surgical services with higher volumes, which were general surgery, ophthalmology, pediatric surgery, and plastic surgery.
48
Ballou, S., W. Hirsch, P. Singh, V. Rangan, J. Nee, J. Iturrino, T. Sommers, et al. "Emergency department utilisation for inflammatory bowel disease in the United States from 2006 to 2014." Alimentary Pharmacology & Therapeutics 47, no. 7 (February 7, 2018): 913–21. http://dx.doi.org/10.1111/apt.14551.
Full text
49
Yeargin, Susan, Rebecca Hirschhorn, and Andrew Grundstein. "Heat-Related Illnesses Transported by United States Emergency Medical Services." Medicina 56, no. 10 (October 17, 2020): 543. http://dx.doi.org/10.3390/medicina56100543.
Full textAbstract:
Background and objectives: Heat-related illness (HRI) can have significant morbidity and mortality consequences. Research has predominately focused on HRI in the emergency department, yet health care leading up to hospital arrival can impact patient outcomes. Therefore, the purpose of this study was to describe HRI in the prehospital setting. Materials and Methods: A descriptive epidemiological design was utilized using data from the National Emergency Medical Services (EMS) Information System for the 2017–2018 calendar years. Variables of interest in this study were: patient demographics (age, gender, race), US census division, urbanicity, dispatch timestamp, incident disposition, primary provider impression, and regional temperatures. Results: There were 34,814 HRIs reported. The majority of patients were white (n = 10,878, 55.6%), males (n = 21,818, 62.7%), and in the 25 to 64 age group (n = 18,489, 53.1%). Most HRIs occurred in the South Atlantic US census division (n = 11,732, 33.7%), during the summer (n = 23,873, 68.6%), and in urban areas (n = 27,541, 83.5%). The hottest regions were East South Central, West South Central, and South Atlantic, with peak summer temperatures in excess of 30.0 °C. In the spring and summer, most regions had near normal temperatures within 0.5 °C of the long-term mean. EMS dispatch was called for an HRI predominately between the hours of 11:00 a.m.–6:59 p.m. (n = 26,344, 75.7%), with the majority (27,601, 79.3%) of HRIs considered heat exhaustion and requiring the patient to be treated and transported (n = 24,531, 70.5%). Conclusions: All age groups experienced HRI but particularly those 25 to 64 years old. Targeted education to increase public awareness of HRI in this age group may be needed. Region temperature most likely explains why certain divisions of the US have higher HRI frequency. Afternoons in the summer are when EMS agencies should be prepared for HRI activations. EMS units in high HRI frequency US divisions may need to carry additional treatment interventions for all HRI types.
50
Ovchinnikov, Dmitrii V. "History and continuity of the first therapeutic departments at the Military Medical Academy." Bulletin of the Russian Military Medical Academy 24, no. 1 (April 20, 2022): 139–250. http://dx.doi.org/10.17816/brmma99838.
Full textAbstract:
The problem of the lack of a statute on the creation of the medicalSurgical Academy arises every time the authors start discussing the history of the medicalSurgical Academy or its subdivisions. There are also misunderstandings in the issue of internal medicine teaching and creation of therapeutic departments. The contents of several historical and archival documents and earlier publications about the period of formation and development of the first therapeutic departments of the Academy (the last third of the 18th to the first half of the 19th century) were clarified. The article also analyzed the general anniversary editions of the academy, dissertations defended on the history of the departments, historical collections, and documents published in the Complete Collection of Laws of the Russian Empire, stored in the archives (Central State Archive of Ancient Acts, Russian State Archive of the Navy, etc.). The teaching of internal medicine started in October 1767 by F.T. Tikhorsky. From 1786, P. Hoffman continued to teach pathology, therapy, and medical practice at the Chief medical School. G.I. Bazilevich was appointed the second professor of pathology and therapy at the MedicoSurgical School. I.A. Smelovsky became the first professor after the college was renamed into academy. I.P. Frank, who created the second therapeutic department, started a direct historical branch of the therapeutic department until 1931, when the Department of the Private Pathology and Therapy merged with the united therapeutic department, and the Department of Propaedeutics of Internal Diseases emerged from it. From 1848 to 1924, the Department of General Therapy, attached to the first department, existed. In 1806, thanks to I.P. Frank, the second therapeutic department was founded, which existed since 1810 and is now the Department of General Therapy. Initially created as the Department of Hospital Therapy Clinic and renamed in 1965 at the insistence of N.S. Molchanov into the Department of Therapeutic Advancement of Physicians № 1 was actually created by the Decree of January 19th, 1842, simultaneously with the appointment of its first full-time head Prof. O.I. Myanovsky.