Journal articles on the topic 'Université Alger 1'

Department of Chemistry, The IIS University, Jaipur-302 020, Rajasthan, India E-mail : rk.bansal@iisuniv.ac.in <em>Manuscript received 25 January 2014, accepted 15 February 2014</em> The Diels-Alder reactions of the &gt;C=P&ndash; functionality in annelated 1,3-azaphospholes and their diaza-analogues have been reviewed. The article includes experimental and theoretical results accomplished in the author&rsquo;s (RKB) laboratories. &nbsp;

Department of Chemistry, University of Rajasthan, Jaipur-302 004 <em>Manuscript received 11 November 1993</em> Approaches to the Synthesis of Anthracyclinones and Heteroanthracyclinones : Synthesis of Benzoy 1-.1 ,4-benzoquinones, their Diels-Alder Reactions and [1,5]-Rearrangement of Adducts.

Abstract While many have documented the changing demographics of universities, understanding the effects of prohibiting mandatory retirement (“uncapping”) has proved challenging. We digitize detailed directories of all American law school faculty from 1971–2017 and show that uncapping in 1994 had dramatic effects. From 1971 to 1993, the percent of faculty above 70—when mandatory retirement would typically have been triggered—remained stable at 1%, but starting in 1994, that proportion increased to 14%. We use a permutation test of moving cohorts to show that these increases are attributable to uncapping. Roughly 39% of faculty members would counterfactually have been subject to mandatory retirement. Effects were less pronounced at public schools, which were more likely to have defined benefits retirement plans. Second, we show that schools with the highest proportion of faculty over 70, and thus most impacted by uncapping, also exhibit the slowest integration of female and minority faculty members. Our study highlights crosscutting effects of civil rights laws: preventing age discrimination can have collateral effects on racial and gender integration.

Decomposition rates of Douglas-fir (Pseudotsugamenziesii (Mirb.) Franco) and red alder (Alnusrubra Bong.) wood (simulating logging residues) were determined in clear-cuttings at the Charles Lathrop Pack Experimental Forest of the University of Washington, which is located approximately 120 km south of Seattle, WA. The influence of diameter (1–2, 4–6, and 8–12 cm), vertical location (buried, on the soil surface, and elevated), season of logging (summer and winter), aspect (north and south), and wood temperature, moisture, and chemistry on wood decomposition rates were determined. Red alder wood decomposed faster (k = 0.035–0.517 year−1) than Douglas-fir wood (k = 0.006–0.205 year−1). In general, buried wood decomposed faster than surface wood, which decomposed faster than elevated wood. Small diameter wood generally decomposed faster than larger diameter wood. Aspect and season of logging had little influence on decomposition rates. Moisture and temperature were the dominant factors related to Douglas-fir wood decomposition, with initial chemistry playing a minor role. Initial wood chemistry, particularly soda solubility, was the dominant factor related to red alder wood decomposition.

Department of Chemistry, University of Roorkee. Roorkee-247 667 <em>Manuscript received 27 February 1990, revised 11 June 1990, accepted 3 July 1990</em> Diels-Alder adducts of maleic anhydride with 2,6-dihydroxynaphthalene, 2,7-dihydroxynaphthalene and 6-bromo-2-naphthol have been converted into their <em>o</em>-tolylimide and 1-naphthylimide derivatives. Restricted rotation and non-planar conformations about the aryl C-N bond in <em>ortho</em>-substituted arylimides have been employed in solving structural problem by pmr spectroscopy.

Zusammenfassung Die beiden Bibliotheken Biblioteca dell’Accademia di architettura in Mendrisio (BAAM) und Biblioteca universitaria Lugano (BUL) bilden zusammen die Biblioteche dell’Università della Svizzera italiana (USI). In den letzten Jahren haben sie gemeinsame, aber auch autonome Projekte durchgeführt. Die BUL hat zur Schaffung der BiblioAgorà auf dem neuen Campus Lugano-Viganello beigetragen, einem Raum, der die Bibliotheksdienste von USI und Scuola universitaria professionale della Svizzera italiana (SUPSI) beherbergen soll. Die BAAM hat im Januar 2021, nach mehrjährigen Renovierungsarbeiten den 1. Stock des Palazzo Turconi, eines Krankenhausbaus aus der Mitte des 19. Jahrhunderts, bezogen. Die Konzeption der neuen Bibliothek auf 1 800 qm, die über sehr heterogene Bestände und Sondersammlungen, wie Autorenbibliotheken, Archivalien, Fotografie- und Graphikbestände und eine Rarasammlung verfügt, wurde in enger Zusammenarbeit mit dem Architekturbüro Cube aus Lausanne erarbeitet. Ziel war die Freihandaufstellung und Zugänglichmachung möglichst aller Bestände unter Beibehaltung optimaler konservatorischer Bedingungen.

A simple mathematical model for diffusion of hydrogen within the retina has been developed. The model consists of three, well-mixed, one dimensional layers that exchange hydrogen via a diffusion process. A Fourier series method is applied to compute the hydrogen concentration. The effect of important parameters is examined and discussed. The results may contribute to an understanding of the hydrogen clearance technique to estimate blood flow. A two dimensional numerical method for the hydrogen diffusion is also presented. It is shown that the predominant features of the process are captured quite well by the simpler model. References V. A. Alder, D. Y. Yu, S. J. Cringle and E. N. Su. Experimental approaches to diabetic retinopathy. Asia-Pac. J. Ophthalmol. 4:20–25, 1992. J. C. Arciero, P. Causin and F. Malgoroli. Mathematical methods for modeling the microcirculation. AIMS Biophys. 4:362–399, 2017. doi:10.3934/biophy.2017.3.362 D. E. Farrow, G. C. Hocking, S. J. Cringle and D.-Y. Yu. Modeling Hydrogen clearance from the retina. ANZIAM J. 59:281–292, 2018. doi:10.1017/S1446181117000426 A. B. Friedland. A mathematical model of transmural transport of oxygen to the retina. Bull. Math. Biol. 40:823–837, 2018; doi:10.1007/BF02460609 D. Goldman. Theoretical models of microvascular oxygen transport to tissue. Microcirculation 15:795–811, 2008. doi:10.1080/10739680801938289 A. C. Hindmarsh. ODEPACK, A Systematized Collection of ODE Solvers. In Scientific Computing, R. S. Stepleman, et al., Eds., pp. 55-64. North-Holland, Amsterdam, 1983. S. S. Kety. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol. Rev. 3:1–41, 1951. http://pharmrev.aspetjournals.org/content/3/1/1 B. P. Leonard. A stable and accurate convective modelling procedure based on quadratic upstream interpolation. Comput. Methods Appl. Mech. Eng. 19:59–98, 1979. doi:10.1016/0045-7825(79) 90034-3 S. L. Mitchell. Coupling transport and chemistry: numerics, analysis and applications. PhD thesis, University of Bath, UK, 2003. https://researchportal.bath.ac.uk/en/studentTheses/coupling-transport-and-chemistry-numerics-analysis-and-applicatio G. A. Winchell. Mathematical model of inert gas washout from the retina: evaluation of hydrogen washout as a means of determining retinal blood flow in the cat. Master\textquoteright s Thesis, Northwestern University, Evanston, USA, 1983. https://search.library.northwestern.edu/permalink/f/5c25nc/01NWU_ALMA21563278530002441 D. Y. Yu, V. A. Alder and S. J. Cringle. Measurement of blood flow in rat eyes by hydrogen clearance. Am. J. Physiol. (Heart Circ. Physiol.) 261:H960–H968, 1991. doi:10.1152/ajpheart.1991.261.3.H960 D. Y. Yu, S. J. Cringle, V. A. Alder, E. N. Su, and P. K. Yu, Intraretinal oxygen distribution and choroidal regulation in the avascular retina of guinea pigs. Am. J. Physiol. (Heart Circ. Physiol.) 270:H965-H973, 1996. doi:10.1152/ajpheart.1996.270.3.H965 S. Cringle, D.-Y. Yu, V. Alder, E.-N. Su, and P. Yu. Choroidal regulation of oxygen supply to the guinea pig retina. In A. G. Hudetz, and D. F. Bruley (Eds.), Oxygen Transport to Tissue XX, pp. 385–389. Springer, 1998. doi:10.1007/978-1-4615-4863-8

An experiment was conducted to determine the effect of an application of biostimulants, against the background of varied nitrogen regime, on the share of neutral detergent fraction (NDF), acid detergent fraction (ADF), and acid detergent lignin (ADL) in the crude fiber fraction of Italian ryegrass as well as its digestibility. A field experiment was arranged as a randomized subblock design (split-plot) with three replicates at the Siedlce Experimental Unit of the University of Natural Sciences and Humanities in Poland in 2013. The following factors were examined: type of biostimulant: Algex, Tytanit, Asahi SL and a control; nitrogen application rate: 0 (control); 120 and 180 kg·ha−1. There were confirmed positive effects resulting from an application of biostimulants in Italian ryegrass cultivation. There was confirmed the assumed hypothesis that an application of both natural and synthetic biostimulants will make it possible to improve the feeding value of grasses by reducing the fiber fraction. Particular attention should be paid to the biostimulant Algex whose application in Italian ryegrass cultivation produced the most beneficial response in terms of the share of NDF, ADF, and ADL fractions, which resulted in the greatest increase in the plant dry matter digestibility. Increasing nitrogen rates significantly reduced the quantity of analyzed fiber fractions, and increased grass digestibility.

For solid fuels ash melting temperature is recommended to be higher than 1000°C, so that it can be used in automated furnaces; therefore-promising energy crops are investigated as renewable energy source. This paper presents the results of tests on melting temperature of different energy crop ashes.The field trial was carried out in the study farm of the Latvia University of Agriculture "Pēterlauki" (56°53'N, 23°71'E) in the sod calcareous soils characterized by pH KCl 6.7, P 52 mg kg-1, K 128 mg kg-1, organic matter content from 21 to 25 g kg-1 in the soil. Energy crops analysed: reed canary grass (Phalaris arundinacea L.), birch (Betula pendula Roth.), osier (Salix spp.), grey alder (Alnus incana (L.) Moench), poplar (Populus tremula L.), hybrid aspen (Populus tremuloides x Populus tremula). Results indicate that the ash melting temperature (D, St, Ht, Ft) for the wood energy crops were higher than for the studied grass energy crops and their mixture. Ash melting temperature in all phases over 1200°C was observed for such poplar and hybrid aspen mixture proportions: 3 parts of wood and 1 part of reed canary grass, or 1 part of wood and 1 part of reed canary grass.

Flea beetle (Chrysomelidae) egg deposition has been found on three impressions of alder (Alnus parvifolia) leaves collected at a roadcut in Republic, Washington. These fossils were discovered by Wes Wehr (University of Washington, Burke Museum) during investigations of fossil plants from the Republic, Washington, area. These impressions represent a yet to be determined species, belonging to the genus Altica GeofFroy (1762). They represent the first member of this genus to be described from the Eocene of North America. The fossils were found in lacustrine rocks from the lower part of the Klondike Mountain Formation. Figure 1 represents the Republic fossil locality and the distribution of this Formation. A brief description of the geologic history of this region can be found in Wolfe and Wehr (1987). The Klondike Mountain Formation has a radiometric age that ranges from 42.3 ± 2.0 to 50.3 ± 1.7 m.y. (Pearson and Obradovich, 1977).

Vast areas of the Iberian Peninsula are covered by monocultures of the exotic treeEucalyptus globulus. Given that (1) leaf litter produced in the riparian areas is the main energy source for small streams, and (2) trees differ in their nutrient content, chemical defenses, and physical attributes, eucalypt plantations have the potential to affect the biology of streams. Research teams from the University of Coimbra and the University of the Basque Country have been addressing the potential effects of eucalypt plantations at several levels of study. Here we review the main conclusions of these investigations.Eucalypt plantations produced less litter than some deciduous forests. However, there were marked differences in timing of litterfall: litter production peaked during autumn in deciduous forests, whereas in the eucalypt forests it tended to peak in summer and to be more evenly distributed throughout the year. Despite these differences, the average standing stock of organic matter was higher in the eucalypt than in the deciduous forest. This may be attributed to (1) the occurrence of spates or heavy rain in autumn, the period of maximum litter fall in deciduous forests, and (2) bark accumulation in eucalypt forests. Because of differences in leaf composition, the nutrient input in eucalypt forests seems to be lower than in deciduous forests. The rate of decomposition of eucalypt leaves was strongly dependent on nutrients in the water: in nutrient-poor waters it was slower than that of most other leaf species, whereas in nutrient-rich waters it can be as fast as alder – a fast-decaying species.The biomass and cumulative diversity of aquatic hyphomycetes colonizing leaves did not differ between eucalypt and other native leaf species, but fungal sporulation generally peaked 2 weeks later on eucalypt leaves. This lag disappeared when lipids (but not polyphenolics) were chemically removed from eucalypt leaves. Similarly, addition of eucalypt oils to culture media retarded or suppressed fungal growth. Streams bordered byEucalyptushad lower diversity of fungal spores (but similar spore densities) in Portugal; less consistent patterns were found in similar experiments in Spain.Eucalyptusleaves proved to be poor food for shredders. Under laboratory conditions leaves ofEucalyptusranked low in food selection experiments using native shredders. The same shredders failed to grow and died when fed exclusively eucalypt leaves. The removal of oils from eucalypt leaves resulted in increased feeding rates, whereas the transfer of oils to alder leaves resulted in decreased feeding rates.The effect of eucalypt plantations on stream invertebrate communities is not very consistent. In nutrient-poor waters, fewer invertebrates colonized eucalypt than alder leaves, but this effect was mitigated after a microbial conditioning period in nutrient-rich waters. Portuguese streams bordered byEucalyptushad lower numbers of invertebrates than streams surrounded by deciduous forests. In Spanish streams differences were less marked and nonexistent when looking at the composition of the communities, which change more from year to year than from site to site. Most of the eucalypt streams studied in Portugal and Spain dried up in summer, a fact that might reflect an increase in soil hydrophobity produced byEucalyptusplantations.The very short planting-to-harvest period of eucalypt plantations results in additional impacts, such as soil loss, siltation of streams, or reduced amounts of woody debris in stream channels, which affects their capacity to retain leaf-litter, as well as the availability of habitat for invertebrates and fish. The studies by the Portuguese and Spanish research teams confirm the importance of maintaining riparian buffer strips to reduce human impact on streams and rivers.

NOTICIAS / NEWS (“Transfer”, 2015) 1) CONGRESOS / CONFERENCES: 1. First Forlì International Workshop – Corpus-based Interpreting Studies: The State of the Art University of Bologna at Forlì, 7-8 May 2015. http://eventi.sslmit.unibo.it/cis1/&lt;file:///owa/redir.aspx 2. 5th IATIS Conference – Innovation Paths in Translation and Intercultural Studies, Belo Horizonte, Brazil, 7-10 July 2015. www.iatis.org/index.php/iatis-belo-horizonte-conference/itemlist/category/168-call-for-communication-proposals-within-the-general-conference 3. POETRY/TRANSLATION/FILM – POÉSIE/TRADUCTION/FILM PoeTransFi, Paul Valéry University, Montpellier, France, 18-19 June 2015. http://pays-anglophones.upv.univ-montp3.fr/?page_id=1795 4. 6th International Maastricht-Lodz Duo Colloquium on “Translation and Meaning”, Maastricht School of Translation &amp; Interpre-ting, Zuyd University of Applied Sciences, Maastricht, Netherlands 21-22 May 2015. www.translation-and-meaning.nl 5. MiddleWOmen. Networking and cultural mediation with and between women (1850-1950). Centre for Reception Studies (CERES), HERA Travelling TexTs project and Huygens ING KU Leuven campus Brussels 7-8 May 2015. www.receptionstudies.be 6. 5th International Symposium: Respeaking, Live Subtitling and Accessibility, Università degli Studi Internazionali di Roma, Italy, 12 June 2015. www.unint.eu/it/component/content/article/8-pagina/494-respeaking-live-subtitling-and-accessibility.html 7. Conference on Law, Translation and Culture (LTC5) and Legal and Institutional Translation Seminar, University of Geneva, Switzerland 24-26 June 2015. www.unige.ch/traduction-interpretation/recherches/groupes/transius/conference2015_en.html 8. 6th International Conference Media for All – Audiovisual Translation and Media Accessibility: Global Challenges, University of Western Sydney, Australia, 16-18 September 2015. http://uws.edu.au/mediaforall 9. Translation in Exile, Vrije Universiteit Brussel, 10-11 December 2015. www.cliv.be 10. Literary Translation as Creation, Université d’Avignon et des Pays de Vaucluse, 20-21 May 2015. laurence.belingard@univ-avignon.fr marie-francoise.sanconie@univ-avignon.fr 11. 4th International Conference on Language, Medias and Culture (ICLMC 2015) 9-10 April 2015. Kyoto, Japan, www.iclmc.org 12. 9th International Colloquium on Translation Studies in Portugal – Translation &amp; Revolution, Universidade Católica Portuguesa, Lisbon, 22-23 October 2015. ix.translation.revolution@gmail.com 13. Translation as Collaboration: Translaboration?, University of Westminster, London, 18 June 2015 Contact: Alexa Alfer (A.Alfer01@westminster.ac.uk), Steven Cranfield (S.Cranfield@westminster.ac.uk), Paresh Kathrani (P.Kathrani@westminster.ac.uk) 14. Translation/Interpreting Teaching and the Bologna Process: Pathways between Unity and Diversity, FTSK Germersheim, Germany 27–29 November 2015. www.fb06.uni-mainz.de/did2015/index_ENG.php 15. Atlantic Communities: Translation, Mobility, Hospitality, University of Vigo, Spain, 17-18 September 2015. http://translating.hypotheses.org/551 16. Exploring the Literary World III: Transgression and Translation in Literature Chulalongkorn University, Bangkok, Thailand 23-24 April 2015. www.arts.chula.ac.th/~complit/complite/?q=conference 17. Authenticity and Imitation in Translation and Culture, University of Social Sciences and Humanities, Warsaw, Poland, 7 – 9 May 2015. www.swps.pl/english-version/news/conferences/12164-authenticity-and-imitation-in-translation-and-culture 18. Translation in Transition, Barnard College, New York City, USA 1-2 May 2015. barnard.edu/translation/translation-in-transition 19. First Forlì International Workshop – Corpus-based Interpreting Studies: The state of the art, University of Bologna at Forlì, Italy, 7-8 May 2015. http://eventi.sslmit.unibo.it/cis1 20. Translation and Meaning. The Lodz Session of the 6th International Maastricht-Lodz Duo Colloquium, University of Lodz, Poland, 18-19 September 2015. http://duo.uni.lodz.pl 21. TAO-CAT-2015, Université Catholique de l’Ouest, Angers, France 28-30 May 2015. www.tao2015.org/home-new 22. English Language and Literary Studies (ELLS 2015), Chulalongkorn University, Bangkok, Thailand, 3-4 August 2015. http://ells2015.com 23. Talking to the World 2: The Relevance of Translation and Interpreting – Past, Present and Future, Newcastle University, UK, 10-11 September 2015. www.ncl.ac.uk/sml/study/postgraduate/T&amp;I/2015conference/main.htm 24. 6th International Symposium for Young Researchers in Translation, Interpreting, Intercultural Studies and East Asian Studies Universitat Autònoma de Barcelona, Spain, 3 July 2015. www.fti.uab.es/departament/simposi-2015/en/index.htm 25. Portsmouth Translation Conference: Border Crossing or Border Creation?, University of Portsmouth, UK, 14 November 2015. www.port.ac.uk/translation/events/conference 26. New Perspectives in Assessment in Translation Training: Bridging the Gap between Academic and Professional Assessment, University of Westminster, London, UK, 4 September 2015. www.westminster.ac.uk/news-and-events/events/humanities/archive/2014/mlc/new-perspectives-in-assessment-in-translation-training-bridging-the-gap-between-academic-and-professional-assessment 27. III Congreso Internacional de Neología en las Lenguas Románicas University of Salamanca, 22-24 October 2015. http://diarium.usal.es/cineo2015 28. Some Holmes and Popovič in all of us? The Low Countries and the Nitra Schools in the 21st century, Constantine the Philosopher University, Nitra, Slovakia, 8-10 October 2015. Contact: igor.tyss@gmail.com 29. The Cultural Politics of Translation, Cairo, Egypt, 27-29 October 2015. https://culturalpoliticstranslation2015.wordpress.com 30. Journée d’étude « le(s) figure(s) du traducteur », Mount Royal University, Calgary, Canada, 30 April 2015. http://mrujs.mtroyal.ca/index.php/cf/index 31. Mediterranean Editors and Translators Annual Meeting —Versatility and readiness for new challenges, University of Coimbra, Portugal, 29-31 October 2015. www.metmeetings.org/en/preliminary-program:722 32. Lengua, Literatura y Traducción “liLETRAd”, University of Seville, Spain, 7-8 July 2015. http://congreso.us.es/liletrad. 33. Meta: Translators' Journal is celebrating its 60th anniversary in 2015! For the occasion, an anniversary colloquium will be held on August 19th to 21st, 2015 at the Université de Montréal (Montréal, Canada). Colloquium for the 60th Anniversary of META – 1955-2015: Les horizons de la traduction: retour vers le futur. Translation’s horizons: back to the future. Los horizontes de la traducción: regreso al futuro, August 19-21, 2015 – Université de Montréal. Please send your proposal to this address: meta60e@gmail.com, to the attention of Georges L. Bastin or Eve-Marie Gendron-Pontbrian 2) CURSOS DE POSGRADO / MASTERS: 1. Legal Translation, Master universitario di II livello in Traduzione Giuridica University of Trieste, Italy. http://apps.units.it/Sitedirectory/InformazioniSpecificheCdS/Default.aspx?cdsid=10374&amp;ordinamento=2012&amp;sede=1&amp;int=web&amp;lingua=15 2. Traducción Especializada, Universitat Oberta de Catalunya (UOC), Spain. http://estudios.uoc.edu/es/masters-posgrados-especializaciones/master/artes-humanidades/traduccion-especializada/presentacion 3. Online course: La Traducción Audiovisual y el Aprendizaje de Lenguas Extranjeras, Universidad Nacional de Educación a Distancia, Madrid, 1st December 2014 to 31st May 2015. http://formacionpermanente.uned.es/tp_actividad/idactividad/7385 https://canal.uned.es/mmobj/index/id/21174 Contact: Noa Talaván (ntalavan@flog.uned.es), José Javier Ávila (javila@flog.uned.es) 4. Online course: Audio Description and Its Use in the Foreign Language Classroom, UNED, Madrid, Spain http://formacionpermanente.uned.es/tp_actividad/idactividad/7492 5. Online course: Curso de Formación de Profesorado, La Traducción Audiovisual y el Aprendizaje de Lenguas Extranjeras UNED, Madrid, Spain. http://formacionpermanente.uned.es/tp_actividad/idactividad/7385 6. EST Training Seminar for Translation Teachers, Kraków, Poland 29 June – 3 July 2015. www.est-translationstudies.org/events/2015_seminar_teachers/index.html 7. Train the Trainer -Teaching MT: EAMT-funded Workshop, Dublin City University, 30 April- 1 May 2015. https://cttsdcu.wordpress.com/eamt-workshop-on-teaching-mt-to-translator-trainers-30-april-1-may 3) CURSOS DE VERANO / SUMMER COURSES: 1. 2015 Nida School of Translation Studies, Leading Edges in Translation: World Literature and Performativity, San Pellegrino University Foundation campus, Misano Adriatico, Italy, 18-29 may 2015. http://nsts.fusp.it/Nida-Schools/NSTS-2015 2. EMUNI Translation Studies Doctoral and Teacher Training Summer School, University of Turku, Finland, 1-12 June 2015. www.utu.fi/en/units/hum/units/languages/EASS/Pages/home.aspx 3. Chinese-English Translation and Interpretation, School of Translation and Interpretation, University of Ottawa, Canada, 13th July – 7th August 7 2015. http://arts.uottawa.ca/translation/summer-programs 4. Summer Program in Translation Pedagogy, University of Ottawa 13 July – 7 August 2015. http://arts.uottawa.ca/translation/summer-programs 4) LIBROS / BOOKS: 1. Audio Description: New Perspectives Illustrated, Edited by Anna Maszerowska, Anna Matamala and Pilar Orero, John Benjamins, 2014. https://benjamins.com/#catalog/books/btl.112/main 2. Call for papers: Translation Studies in Africa and beyond: Reconsidering the Postcolony, Editors: J Marais &amp; AE Feinauer Contacts: Kobus Marais (jmarais@ufs.ac.za) or Ilse Feinauer (aef@sun.ac.za). 4. Measuring live subtitling quality: Results from the second sampling exercise, Ofcom, UK. http://stakeholders.ofcom.org.uk/consultations/subtitling/sampling-results-2 5. A Training Handbook for Legal and Court Interpreters in Australia by Mary Vasilakakos, ISBN 978-0-9925873-0-7, Publisher: Language Experts Pty Ltd. www.interpreterrevalidationtraining.com www.languageexperts.com.au 6. Call for papers: Opera and Translation: Eastern and Western Perspectives, Edited by Adriana Serban and Kelly Kar Yue Chan http://pays-anglophones.upv.univ-montp3.fr/?page_id=1908 7. The Known Unknowns of Translation Studies, Edited by Elke Brems, Reine Meylaerts and Luc van Doorslaer, Amsterdam/Philadelphia: John Benjamins, 2014. https://benjamins.com/#catalog/books/bct.69/main 8. Translating the Voices of Theory/ La traduction des voi de la théorie Edited by Isabelle Génin and Ida Klitgård, 2014. www.hf.uio.no/ilos/english/research/groups/Voice-in-Translation/ 9. Authorial and Editorial Voices in Translation 1 - Collaborative Relationships between Authors, Translators, and Performers, Eds. Hanne Jansen and Anna Wegener, 2014. http://editionsquebecoisesdeloeuvre.ca/data/documents/AEVA-Flyer-1-190895-Vita-Traductiva-Vol-2-Flyer-EN-100413.pdf 10. Authorial and Editorial Voices in Translation 2 - Editorial and Publishing Practices, Eds. Hanne Jansen and Anna Wegener, 2014. www.editionsquebecoisesdeloeuvre.ca/accueil 11. Call for papers: Achieving Consilience. Translation Theories and Practice. https://cfpachievingconsilience.wordpress.com 12. Framing the Interpreter. Towards a visual perspective. Anxo Fernández-Ocampo &amp; Michaela Wolf (eds.), 2014, London: Routledge. http://routledge-ny.com/books/details/9780415712743 13. Multilingual Information Management: Information, Technology and Translators, Ximo Granell, 2014. http://store.elsevier.com/Multilingual-Information-Management/Ximo-Granell-/isbn-9781843347712/ 14. Writing and Translating Francophone Discourse: Africa, The Caribbean, Diaspora, Paul F. Bandia (ed.), 2014, Amsterdam, Rodopi www.brill.com/products/book/writing-and-translating-francophone-discourse 15. Call for papers (collective volumen): Translation studies in Africa and beyond: Reconsidering the postcolony www.facebook.com/notes/mona-baker/translation-studies-in-africa-and-beyond-reconsidering-the-postcolony/743564399051495 16. Audiovisual Translation in the Digital Age - The Italian Fansubbing Phenomenon, By Serenella Massidda, Palgrave Connect, 2015. www.palgrave.com/page/detail/audiovisual-translation-in-the-digital-age-serenella-massidda/?k=9781137470362 17. Video: First International SOS-VICS Conference - Building communication bridges in gender violence, University of Vigo, Spain 25-26 September 2014. http://cuautla.uvigo.es/CONSOS/ 18. Camps, Assumpta. Traducción y recepción de la literatura italiana, Publicacions i Edicions UB, 2014. ISBN: 978-84-475-3776-1. 19. Camps, Assumpta. Italia en la prensa periódica durante el franquismo, Publicacions i Edicions UB, 2014. ISBN: 978-84-475-3753-2. 5) REVISTAS / JOURNALS: Call for papers: “Altre Modernità – Rivista di studi letterarie e culturali” Special Issue: Ideological Manipulation in Audiovisual Translation, Contact: irene.ranzato@uniroma.it. http://riviste.unimi.it/index.php/AMonline/announcement/view/381 2. Call for papers: “Between, Journal of the Italian Association of Comparative Literature”. Special issue on censorship and self-censorship. http://ojs.unica.it/index.php/between/pages/view/CFP9_censura_auto-censura 3. Open access journal, “Hieronymus, A Journal of Translation Studies and Terminology”, Croatia. www.ffzg.unizg.hr/hieronymus 4. “DIE SCHNAKE. Zeitschrift für Sprachkritik, Satire, Literatur”, Number 39+40, Kleines ABC des Literaturübersetzens. www.rainer-kohlmayer.de 5. Call for papers: “MonTI” 8 (2016) - Economic, Financial and Business Translation: from Theory to Training and Professional Practice. http://dti.ua.es/es/monti-english/monti-authors.html daniel.gallego@ua.es 6. Call for papers: “LINGUISTICA ANTVERPIENSIA”, NEW SERIES -Themes in Translation Studies (15/2016). Interpreting in Conflict Situations and in Conflict Zones throughout History. https://lans.ua.ac.be/index.php/LANS-TTS/announcement 7. Call for papers: “CULTUS: The Journal of Intercultural Mediation and Communication” (8/2016). The Intercultural Question and the Interpreting Professions. www.cultusjournal.com 8. 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Deadline: 20th July 2015. www.webs.ulpgc.es/lfe 14. “The AALITRA Review”. www.nla.gov.au/openpublish/index.php/ALLITRA 15. “Current Trends in Translation Teaching and Learning E” www.cttl.org/cttl-e-2014.html 16. Call for papers: “Current Trends in Translation Teaching and Learning E”. www.cttl.org 18. Call for papers: “Translation and Translanguaging in Multilingual Contexts”, Volume 1, Number 2, 2015 Deadline: 10-Jan-2015. https://benjamins.com/#catalog/journals/ttmc/main 19. Call for book reviews: “TRANS. Revista de Traductología,” vol.19, 2015. Deadline: Friday, 30th January 2015. www.trans.uma.es trans@uma.es 20. Call for papers: “a journal of literature, culture and literary Translation”. Special volume – Utopia and Political Theology Today Deadline: 15th January 2015. Contact: sic.journal.contact@gmail.com https://owl.english.purdue.edu/owl/resource/747/01 21. “trans-kom”. www.trans-kom.eu 22. “Linguistica Antverpiensia” NS-TTS 13/2014: Multilingualism at the cinema and on stage: A translation perspective, Edited by Reine Meylaerts and Adriana Şerban. https://lans-tts.uantwerpen.be/index.php/LANS-TTS/issue/current 23. Call for papers: 5th issue (2015) of “Estudios de Traducción”, Deadline: 20 February 2015. www.ucm.es/iulmyt/revista 24. Call for papers: “Journal of Translation Studies” - special issue on Translator &amp; Interpreter Education in East Asia. KATS (Korean Association of Translation Studies), www.kats.or.kr (Go to 'English' page). Contact: Won Jun Nam (wonjun_nam@daum.net, wjnam@hufs.ac.kr). 25. “The Journal of Specialised Translation”, 23, January 2015. www.jostrans.org 26. Call for papers: “TranscUlturAl: A Journal of Translation and Cultural Studies”. Deadline: 15 March 2015. http://ejournals.library.ualberta.ca/index.php/TC/announcement 27. “New Voices in Translation Studies”, Issue 11 (Fall 2014). www.iatis.org/index.php/publications/new-voices-in-translation-studies/item/1034-issue11-2014 28. “The Interpreter and Translator Trainer”, 8:3 (2014). Special issue: Dialogue Interpreting in practice: bridging the gap between empirical research and interpreter education E. Davitti and S. Pasquandrea (eds.) www.tandfonline.com/toc/ritt20/current#.VLQHuyvF-So 6) WEBS DE INTERÉS / WEBSITES OF INTEREST: 1. Support Spanish interpreters to secure the right to translation and interpreting in criminal proceedings: www.change.org/p/pablo-casado-retiren-el-proyecto-de-ley-org%C3%A1nica-que-modifica-la-lecrim

Bernstein liefert hier die lang erwartete zweite Folge seiner breit angelegten Untersuchung zur Geschichte der Hölle. In einem 1993 erschienenen ersten Band, The Formation of Hell. Death and Retribution in the Ancient and Early Christian Worlds, hatte er die antiken und frühchristlichen Vorstellungen von Bestrafung nach dem Tod behandelt, als die Grundlagen, oder, wie Bernstein lieber sagt, den Hintergrund für die in der Folge ausgebildeten Anschauungen. Diesmal aber geht es um die Erscheinungsformen von ,,Hölle“, definiert als ,,divinely sanctioned place of eternal torment for the wicked“, von ca. 400 bis ca. 800 nach Christus in den drei großen monotheistischen Religionen, Christentum, Judentum und Islam. Die lateinische Christenheit gibt dabei den Schwerpunkt ab, sie nimmt den größten Raum der Darstellung ein, und es ist ihr Sprachgebrauch, in dem Bernstein der ,,Infernalisierung“ des Reichs der Toten – die Verwandlung des ununterschiedenen Aufenthalts aller Verstorbenen in einen Strafort für die Bösen – im Besonderen nachgeht. Tatsächlich lässt sich dieses auch sonst anzutreffende Phänomen hier besonders gut nachweisen: wie die einleitend gebotenen Tabellen zeigen, werden im Sinne der Unterscheidung zwischen inferi und infernus, zwischen dem neutralen Totenland und dem Strafort, in den lateinischen Bibelübersetzungen die hebräischen und griechischen Termini, Sheol und Hades, fast durchwegs mit infernus wiedergegeben.

The objective of this study was to quantitatively characterize the growth, yield and fruit size of cultivars of chokecherry (Prunus virginiana L.), pincherry (Prunus pensylvanica L.f.), highbush cranberry (Viburnum trilobum Marsh.), and black currant (Ribes nigrum L.). Cultivars were evaluated in replicated trials at two sites (Saskatoon and Outlook) in Saskatchewan over 2–5 yr. Espenant, Garrington, Lee Red, and Boughen Yellow were among the highest yielding of the chokecherry cultivars (mean yield = 7.2 kg plant-1 at Saskatoon); of these, Lee Red had the largest fruit. The pincherry cultivar Lee #4 (mean yield = 3.1 kg plant-1) yielded at least twice as much as Mary Liss or Jumping Pound. Highbush cranberry cultivars Alaska, Espenant, Garry Pink, Manitou, and Wentworth averaged yields of 2.0 kg plant-1 at Saskatoon. Of these, Manitou had the largest fruit. Two black currant trials were established; the cultivars included in the second trial were not available at the time of establishment of the first trial. Black currant yields ranged from 0.2 kg plant-1 for Willoughby to 1.0 kg plant-1 for Consort in the first trial, and from 0.2 kg plant-1 for the selection 4-24-29 to 2.0 kg plant-1 for McGinnis Black in the second trial. Black currant cultivars with the largest fruit size included Wellington, Topsy, and three numbered selections from the University of Saskatchewan (mean = 225 fruit/cup) in the first trial, and Ben Sarek, McGinnis Black, and Ben Alder (mean = 156 fruit/cup) in the second trial. Data from the current study provide a basis on which to evaluate the performance of currently available cultivars, and any new cultivars or future selections that may be developed. Key words: Prunus virginiana, Prunus pensylvanica, Viburnum trilobum, Ribes nigrum, fruit size, shoot growth, cultivar evaluation

Febrile neutropenia consecutive to the administration of chemotherapy constitutes the most serious and the most frequent complication of cytotoxic chemotherapies. It is often a sign of infection, being able to quickly turn in septicemia if no treatment is begun; it thus constitutes an emergency for diagnosis and therapeutics. The objective of this work is to study the epidemiological, clinical, biological, etiologic and evolutionary characteristics of the episodes of febrile neutropenia, to evaluate the importance of the infectious risk and the main involved germs, to identify the difficulties of the management and the follow-up of the children having developed a febrile neutropenia and finally. During our retrospective study concerning the episodes of febrile neutropenias diagnosed in the pediatric oncology unit of the pediatric department of the university hospital of Alger over a period of 04 years (from 1 January 2017 to 31 December 2020). 205 patients having solid tumor were collected. Among them 45 cases presented febrile episodes, the average age was 5.75 years with a maximum frequency of them were male, and the main motive for consultation was the fever. The average deadline of occurrence of neutropenia was of 14.6 days. A documentation of the fever is obtained clinically at 20 % of the cases, while in 80 % of the cases, the fever remains unknown origin. The infectious sites found are: a) Skin (6.6%), digestive (4.4%), respiratory (8.8%). b) The average duration of the neutropenia was of 18.8 days. Upon completing this work, we emphasize the need of prompt and appropriate management of the hematological emergency that is febrile neutropenia by an adapted empirical antibiotic therapy after a good bacteriological investigation, without forgetting the importance of prophylaxis based mainly on hygienic mucocutaneous measures and the information/education of parents about the risk of infection and means of prevention.

Beskrivelse: Children’s Global Assessment Scale (CGAS) ble laget av David Shaffer og medarbeidere i 1983. Den skåres av kliniker og er et mål på barns psykososiale funksjonsnivå i den siste måneden før vurderingstidspunktet på en skala fra 1 (lavest fungering) til 100 (utmerket fungering). Den anbefalte aldersgruppen er 4-16/17 år. Det tar mindre enn 10 minutter å skåre CGAS. Det er ikke kjent om det er krav til kompetanse for å skåre CGAS. Ny informasjon om oversettelse og opphavsrett i 2022. Det foreligger nå en offisiell godkjent norsk oversettelse av CGAS. Denne er godkjent av rettighetshaverne ved Colombia University i USA for fri non-profit bruk både digitalt og i papirformat. Den ble oversatt i august 2022 av Lars Ravn Øhlckers, Børge Idar Mathiassen og Ketil Hanssen-Bauer, på vegne av Universitetssykehuset Nord-Norge. Litteratursøk: 34 norske artikler ble inkludert. Av disse hadde 19 flere enn 100 deltagere. De fleste studiedeltakerne var barn i 6-18 års alder, men også noen oppfølgingsstudier av voksne ble inkludert. De inkluderte studiene varierte betydelig med hensyn til type klinisk utvalg og det var både tverrsnitts- og longitudinelle studier. Psykometri: Vi fant tilfredsstillende dokumentasjon på konvergens-, diskriminerende og prediktiv validitet og interraterreliabilitet, men noe mindre på endringssensitivitet. Det manglet studier av test-retest reliabilitet. Konklusjon: Vi anbefaler bruken av den norske versjonen i både forskning og klinikk under forutsetningen av at man systematisk trener klinikere i skåringen.

Abstract (Dansk) Baggrund: Ikke-planlagte genhenvendelser (IPG) til akutmodtagelser (AKM) er ofte anvendt som kvalitetsmarkør, men det er debatteret hvilke patientrelaterede variabler der kan forudsige disse. Dette studie har undersøgt om Degree of Worry (DOW), en ny patient reported outcome, er associeret til IPG ved ankomst til AKM. Formål: At undersøge associationen mellem DOW ved ankomst til AKM og 30 dages IPG. Metode: I et observationelt studie blev 1945 patienter screenet, hvoraf 845 samtykkede og blev inkluderet. Dataindsamlingen blev udført på Hvidovre Hospital, Region Hovedstaden. Eksklusionskriterier var manglende samtykke, &lt;18 år, ikke-dansk talende, højeste triage niveau, fysisk eller mentalt hæmmede, påvirkning af alkohol eller euforiserende stoffer eller ortopædkirurgiske skader. Patienter blev bedt om at vurdere deres DOW ved ankomst til AKM og 30 dages followup up blev lavet via patienternes journaler. Det primære outcome var association mellem en høj DOW (7-10) og 30 dages IPG. Dette blev testet ved tre separate logistiske regressioner, 1) crude, 2) semi-justeret for triage niveau, køn, alder og kronisk sygdom, 3) justeret for self-rated health, triage niveau, køn, alder og kronisk sygdom. Resultat: Associationen mellem IPG og DOW var 1) crude OR (odds ratio) 1.04 (95% CI: 0.74-1.46) for 30-day URV, 2) semi-justeret, OR 0.98 (95% CI: 0.68-1.41), and 3) justeret inklusiv SRH, OR 0.92 (95% CI: 0.63-1.33). Konklusion: Vore analyser viste ingen signifikant association mellem DOW og 30 dages IPG, i alle tre analyser, hvilket kan skyldes timingen af DOW spørgsmålet, manglende power eller en reel manglende association. Abstract (Engelsk) Background: Unscheduled return visits (URVs) to emergency departments (EDs) are widely used as an indicator of quality of care. However, it is debated which patient related variables accurately predict URVs. This study aimed to investigate if Degree of Worry (DOW), a novel patient reported outcome, at arrival is associated with ED URVs. The objective of this study was to investigate the association between DOW and 30-day URV to the ED. Aims: To investigate the association between a novel patient reported outcome measure at Emergency department (ED) arrival with 30-day Unscheduled Return Visits (URV). Methods: An observational study, 1945 patients were screened. 845 were eligible for inclusion and provided informed consent. Setting was the ED at Copenhagen University Hospital, Hvidovre, Capital Region of Denmark. Exclusion criteria were lack of consent, &lt;18 years of age, non-Danish speaking, highest triage level, physically or mentally impairment, affected by drugs or alcohol, or orthopedic injuries. Patients were asked to rate their DOW on arrival to the ED and 30-day URV was determined by follow up in medical records. Primary outcome was the association between high DOW (DOW 7-10) and 30-day URV. This was tested with three logistic regression analyses, 1) crude, 2) semi-adjusted for triage level, sex, age, and chronic disease, 3) adjusted for self-rated health, triage level, sex, age, and chronic disease. Results: The association between URV and DOW was 1) crude, OR (odds ratio) 1.04 (95% CI: 0.74-1.46) for 30-day URV, 2) semi-adjusted, OR 0.98 (95% CI: 0.68-1.41), and 3) fully adjusted including SRH, OR 0.92 (95% CI: 0.63-1.33). Conclusion: Our analysis showed no significant association between DOW at ED-arrival and 30-day URV in all three analyses.

We introduce a two-stage global-then-local search method for solving feasibility problems. The approach pairs the advantageous global tendency of the Douglas–Rachford method to find a basin of attraction for a fixed point, together with the local tendency of the circumcentered reflections method to perform faster within such a basin. We experimentally demonstrate the success of the method for solving nonconvex problems in the context of wavelet construction formulated as a feasibility problem. References F. J. Aragón Artacho, R. Campoy, and M. K. Tam. The Douglas–Rachford algorithm for convex and nonconvex feasibility problems. Math. Meth. Oper. Res. 91 (2020), pp. 201–240. doi: 10.1007/s00186-019-00691-9 R. Behling, J. Y. Bello Cruz, and L.-R. Santos. Circumcentering the Douglas–Rachford method. Numer. Algor. 78.3 (2018), pp. 759–776. doi: 10.1007/s11075-017-0399-5 R. Behling, J. Y. Bello-Cruz, and L.-R. Santos. On the linear convergence of the circumcentered-reflection method. Oper. Res. Lett. 46.2 (2018), pp. 159–162. issn: 0167-6377. doi: 10.1016/j.orl.2017.11.018 J. M. Borwein, S. B. Lindstrom, B. Sims, A. Schneider, and M. P. Skerritt. Dynamics of the Douglas–Rachford method for ellipses and p-spheres. Set-Val. Var. Anal. 26 (2018), pp. 385–403. doi: 10.1007/s11228-017-0457-0 J. M. Borwein and B. Sims. The Douglas–Rachford algorithm in the absence of convexity. Fixed-point algorithms for inverse problems in science and engineering. Springer, 2011, pp. 93–109. doi: 10.1007/978-1-4419-9569-8_6 I. Daubechies. Orthonormal bases of compactly supported wavelets. Commun. Pure Appl. Math. 41.7 (1988), pp. 909–996. doi: 10.1002/cpa.3160410705 N. D. Dizon, J. A. Hogan, and J. D. Lakey. Optimization in the construction of nearly cardinal and nearly symmetric wavelets. In: 13th International conference on Sampling Theory and Applications (SampTA). 2019, pp. 1–4. doi: 10.1109/SampTA45681.2019.9030889 N. D. Dizon, J. A. Hogan, and S. B. Lindstrom. Circumcentering reflection methods for nonconvex feasibility problems. arXiv preprint arXiv:1910.04384 (2019). url: https://arxiv.org/abs/1910.04384 D. J. Franklin. Projection algorithms for non-separable wavelets and Clifford Fourier analysis. PhD thesis. University of Newcastle, 2018. doi: 1959.13/1395028. D. J. Franklin, J. A. Hogan, and M. K. Tam. A Douglas–Rachford construction of non-separable continuous compactly supported multidimensional wavelets. arXiv preprint arXiv:2006.03302 (2020). url: https://arxiv.org/abs/2006.03302 D. J. Franklin, J. A. Hogan, and M. K. Tam. Higher-dimensional wavelets and the Douglas–Rachford algorithm. 13th International conference on Sampling Theory and Applications (SampTA). 2019, pp. 1–4. doi: 10.1109/SampTA45681.2019.9030823 B. P. Lamichhane, S. B. Lindstrom, and B. Sims. Application of projection algorithms to differential equations: Boundary value problems. ANZIAM J. 61.1 (2019), pp. 23–46. doi: 10.1017/S1446181118000391 S. B. Lindstrom and B. Sims. Survey: Sixty years of Douglas–Rachford. J. Aust. Math. Soc. 110 (2020), 1–38. doi: 10.1017/S1446788719000570 S. B. Lindstrom, B. Sims, and M. P. Skerritt. Computing intersections of implicitly specified plane curves. J. Nonlin. Convex Anal. 18.3 (2017), pp. 347–359. url: http://www.yokohamapublishers.jp/online2/jncav18-3 S. G. Mallat. Multiresolution approximations and wavelet orthonormal bases of L2(R). Trans. Amer. Math. Soc. 315.1 (1989), pp. 69–87. doi: 10.1090/S0002-9947-1989-1008470-5 Y. Meyer. Wavelets and operators. Cambridge University Press, 1993. doi: 10.1017/CBO9780511623820 G. Pierra. Decomposition through formalization in a product space. Math. Program. 28 (1984), pp. 96–115. doi: 10.1007/BF02612715

Resumo: O presente artigo, em forma ensaística, não pretende expor nenhuma teoria kierkegaardiana da educação. Antes se esforça por remover alguns mitos a respeito da própria educação de Kierkegaard, e para tanto busca basicamente enfatizar o lado saudável de uma figura materna – em geral ignorada ou menosprezada pelos comentadores. Além disso, denuncia preconceitos de interpretações dinamarquesas, alemãs, francesas e brasileiras.Palavras-chave: Søren Kierkegaard. Ane Sørensdatter Kierkegaard. Georg Brandes. Casamento e procriação. Relações mãe/filho. Psicólogos e problemas psicológicos. Abstract: The present article, in essayistic form, does not intend to expose any kierkegaardian theory of education. It rather makes an effort to remove some myths about Kierkegaard’s own education, in order to which it tries basically to emphasize the sound, wealthy side of a maternal-figure – generally ignored or disdained by several commentators. Beyond, it denounces some prejudices of Danish, German, French and Brazilian interpretations.Keywords: Søren Kierkegaard. Ane Sørensdatter Kierkegaard. Georg Brandes. Marriage and procreation. Mother/son relations. Psychologists and psychological problems. REFERÊNCIASBRANDES, Georg. Nietzsche: Un ensayo sobre el radicalismo aristocrático. Traducción de José Liebermann. México: Sexto piso, 2004.GARFF, Joakim. SAK. Søren Aabye Kierkegaard: En Biografi. København: Gads Forlag, 2000.HIMMELSTRUP, Jens (Udg.). Søren Kierkegaard: International Bibliografi. København: Nyt Nordisk Forlag – Arnold Busk, 1962.HIRSCH, Emanuel. Kierkegaard-Studien, Band 1. (Gesammelte Werke 11.) Waltrop: Spenner, 2006. (Neu herausgegeben und eingeleitet von H. M. Müller. – Reprodução dos originais de 1930-33).JASPERS, Karl. Psicopatología General. Traducción de la 5a. ed. alemana por Roberto Saubinet y Diego Santillan. Buenos Aires: Bini, 1950._______. Psychologie der Weltanschauungen: Fünfte, unveränderte Auflage. Berlin-Göttingen-Heidelberg: Springer 1960. (1919)KIERKEGAARD, Søren A. O Conceito de Ironia constantemente referido a Sócrates. Tradução de Álvaro Valls. Petrópolis: Vozes, 1991._______. Migalhas Filosóficas: ou um bocadinho de filosofia de João Clímacus. Tradução de Álvaro Valls. Petrópolis: Vozes, 1995. (Ou: Tradução de José Miranda Justo. Lisboa: Relógio D’Água, 2012.)_______. In Vino Veritas. Tradução de José Miranda Justo. Lisboa: Antígona, 2005.KIERKEGAARD, Søren A. Ou – Ou: Um Fragmento de Vida (Primeira Parte). Tradução de Elisabete M. de Sousa. Lisboa: Relógio D’Água, 2013._______. Ou – Ou: Um Fragmento de Vida (Segunda Parte) Tradução de Elisabete M. de Sousa. Lisboa: Relógio D’Água, 2017._______. As Obras do Amor: Algumas considerações cristãs em forma de discursos. Tradução de Álvaro Valls. Petrópolis: Vozes; Bragança Paulista: Ed. Univ. São Francisco, 2005._______. Diapsalmata. Tradução, Notas e Posfácio de Nuno Ferro e M. J. de Carvalho et al.. Lisboa: Assírio &amp; Alvim, 2011._______. Do Desespero Silencioso ao Elogio do Amor Desinteressado: Aforismos, novelas e discursos de Søren Kierkegaard. Tradução de Álvaro Valls. Porto Alegre: Escritos, 2004.KIRMMSE, Bruce. Kierkegaard In Golden Age Denmark: Bloomington &amp; Indianapolis: Indiana University Press, 1990.KIRMMSE, Bruce (Org.). Encounters With Kierkegaard: A Life as Seen by His Contemporaries. Princeton, NJ: Princeton University Press, 1996.KJÆR, Grette. Den Gådefulde Familie: Historien bag det Kierkegaardske Familiegravsted. København: Reitzels Boghandel, 1981.MALIK, Habib C. Receiving Søren Kierkegaard: The Early Impact and Transmission of His Thought. Washington D.C.: The Catolic University of America Press, 1997.MESNARD, Pierre. Le Vrai Visage de Kierkegaard. Paris: Beauchesne, 1948.ODEN, Thomas (Org.) The Humour of Kierkegaard: An Anthology. Princeton and Oxford: Princeton University Press, 2004.POOLE, Roger &amp; STANGERUP, Henrik (Org.). The Laughter Is on My Side: An Imaginative Introduction to Kierkegaard. Princeton, NJ: Princeton University Press,1989.STEWART, Jon. A History of Hegelianism in Golden Age Denmark. Tome I. The Heiberg Period: 1824-1836. Copenhagen: SKRC/Reitzel, 2007.THEUNISSEN, Michael. Der Begriff Ernst bei Sören Kierkegaard. Freiburg/München: Alber, 1978. (Com a dedicatória: “Meiner Mutter”!)VERGOTE, Henri–Bernard. Sens et repetition: Essai sur l’ironie kierkegaardienne. Tomes I et II. Paris: Cerf/Orante, 1982.WAHL, Jean. Études Kierkegaardiennes. 4e. édition. Paris: Vrin, 1974.

Functionals related to a solution of a problem, usually modelled by partial differential equations, can be important quantities used to capture features of the problem. For high dimensional problems the computational cost of the functionals can be large since the numerical solution of a high dimensional partial differential equation is usually expensive to compute. We develop a new sparse grid combination technique to reduce the computational cost of such functionals. Our method is based on error splitting models of the functionals. However, it is hard to obtain a concrete error splitting model for complicated approximations. We show the connection between the decay of the surpluses and the error splitting models. By using the connection, we can also apply our combination technique to functionals when we only know their computed surpluses. Numerical experiments are provided to illustrate our idea and test the performance of our method. References A. J. Brizard and T. S. Hahm. Foundations of nonlinear gyrokinetic theory. In: Rev. Mod. Phys. 79.2 (2007), pp. 421–468. doi: 10.1103/RevModPhys.79.421 H.-J. Bungartz and M. Griebel. Sparse grids. In: Acta Numer. 13 (2004), pp. 147–269. doi: 10.1017/S0962492904000182 T. Gerstner and M. Griebel. Numerical integration using sparse grids. In: Numer. Algor. 18 (1998), pp. 209–232. doi: 10.1023/A:1019129717644. M. Griebel, M. Schneider, and C. Zenger. A combination technique for the solution of sparse grid problems. In: Iterative methods in linear algebra: Proceedings of the IMACS International Symposium on Iterative Methods in Linear Algebra, 1991. Ed. by P. de Groen and R. Beauwens. North-Holland, Amsterdam, 1992, pp. 263–281. url: https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.33.3530 B. Harding. Fault tolerant computation of hyperbolic partial differential equations with the sparse grid combination technique. PhD thesis. The Australian National University, 2016. url: https://openresearch-repository.anu.edu.au/bitstream/1885/101226/1/Harding%20Thesis%202016.pdf M. Hegland. Adaptive sparse grids. In: Proceedings of the 10th Computational Techniques and Applications Conference CTAC-2001. Ed. by K. Burrage and R. B. Sidje. Vol. 44. 2003, pp. C335–C353. doi: 10.21914/anziamj.v44i0.685 Gene Development Team; F. Jenko et al. The Gyrokinetic Plasma Turbulence Code Gene: User Manual. 2013. url: http://genecode.org/

Polycyclic Aromatic Hydrocarbons (PAH) are sizeable molecules formally obtained by the multiple “fusion” of aromatic rings. Such nanometre-size carbon materials show extremely interesting physical properties: electrical conductivity, light absorption, and emission, leading to their use in organic electronics, sensors, and energy applications [1]. Different experimental strategies can be exploited to form larger molecular architectures starting from non-conjugated systems. Classical approaches are mostly based on chemical synthetic procedures that involve the use of polynuclear aromatic hydrocarbons (PAH). More recently many works have shown the advantages of new electrochemical PAH synthesis via an anodic electrochemical oligomerization [2]. Electric current can be used as an oxidant to replace strong chemical oxidizing agents for new C–C bond generation [3] obtaining PAH film with Charge and Exciton Transport on the electrode surface [4]. For this study, the C96 dendrimers (PPD) was synthesized by the Diels-Alder reaction between the 1,3,5-triethynylbenzene and the 2,3,4,5-tetra phenyl-2,4-cyclopentadien-1-one according to literature procedure [5]. Thus, pPPD film structures were electrochemically grown on ultra-flat indium tin oxide (ITO) electrodes by electrochemical oxidation of C96 PPD dendrimers. A preliminary characterization of the relevant films was carried out using Laser Desorption-Ionization Mass Spectra (MALDI-TOF-MS), Gel-Permeation Chromatography (GPC) measurements, and UV/vis spectroscopy. In particular, the electronic properties of pPPD were studied using near edge XAS determining the valence band photoemission. The experimental results were then compared with DFT calculations, to assess the extent of conjugation obtained in the materials. All the collected experimental evidence consistently indicates that uniform films of pPDD supramolecular architectures are formed via electrochemical oxidation. Remarkably, the use of electrochemical-based methods paves the way for preparing and characterizing complex molecular architectures, from 2D SAMs to organic, inorganic, and hybrid polymers. The authors acknowledge the support offered by Project 2022NW4P2T CUP B53D23013890006 “From metal nanoparticles to molecular complexes in electrocatalysis for green hydrogen evolution and simultaneous fine chemicals production” PRIN2022 Progetti di Ricerca di Rilevante Interesse Nazionale funded by the Italian Ministry of University and Research and NextGenerationEU. References [1] Z. Liu, S. Fu, X. Liu, A. Narita, P. Samorì, M. Bonn, H.I. Wang, Small Size, Big Impact: Recent Progress in Bottom‐Up Synthesized Nanographenes for Optoelectronic and Energy Applications, Advanced Science 9 (2022) 2106055. https://doi.org/10.1002/advs.202106055. [2] C. Zeng, W. Zheng, H. Xu, S. Osella, W. Ma, H.I. Wang, Z. Qiu, K. Otake, W. Ren, H. Cheng, K. Müllen, M. Bonn, C. Gu, Y. Ma, Electrochemical Deposition of a Single‐Crystalline Nanorod Polycyclic Aromatic Hydrocarbon Film with Efficient Charge and Exciton Transport, Angew Chem Int Ed 61 (2022). https://doi.org/10.1002/anie.202115389. [3] M. Bonechi, W. Giurlani, A. Stefani, A. Marchetti, M. Innocenti, C. Fontanesi, Resorcinol electropolymerization process obtained via electrochemical oxidation, Electrochim. Acta 428 (2022) 140928. https://doi.org/10.1016/j.electacta.2022.140928. [4] M. Bonechi, A. Marchetti, W. Giurlani, D. Vanossi, L. Pasquali, S. Campidelli, C. Fontanesi, M. Innocenti, Electrochemical growth of PAH-dendrimers supramolecular films. An integrated experimental-theoretical approach, Electrochimica Acta 474 (2024) 143435. https://doi.org/10.1016/j.electacta.2023.143435. [5] V.S. Iyer, M. Wehmeier, J.D. Brand, M.A. Keegstra, K. Müllen, From Hexa‐ peri ‐hexabenzocoronene to “Superacenes,” Angew. Chem. Int. Ed. Engl. 36 (1997) 1604–1607. https://doi.org/10.1002/anie.199716041.

Abstract Background: Antibody-drug conjugates (ADCs) targeting trophoblast cell-surface antigen 2 (TROP-2) and hepatocyte growth factor receptor (cMET) are promising therapies for non-small cell lung cancer (NSCLC). However, their clinical application requires robust and rapid biomarker evaluation that addresses expression heterogeneity and avoid interobserver variability. Current approaches based on pathologist assessments are limited by subjectivity and scalability. This study aimed to develop a generalizable AI model for ADC biomarker evaluation, trained on TROP-2 and inferred on cMET, to validate its adaptability across markers. Additionally, the model’s performance was compared with expert pathologists to assess its clinical utility. Finally, biomarker prevalence in the two main NSCLC subtypes, namely adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), was evaluated. Methods: We collected a bicentric real-world sample group of 1142 patients with resected NSCLC from the Charité, Berlin and the University Hospital Cologne. For tissue microarray construction, two 1.5-mm tissue cores were punched from formalin-fixed and paraffin-embedded tumor blocks. Immunohistochemical staining for TROP-2 and cMET was performed and sections were scanned for AI-based analysis. The AI pipeline comprised three models: a cell detection model for the identification of cells, a cell classification model for the differentiation of tumor and other cells, and an expression scoring model for membranous biomarker quantification. The model was trained on TROP-2, and subsequently inferred on cMET, thus enabling an evaluation of cross-marker generalization. Five pathologists with varying levels of expertise manually evaluated a representative subset, using H-scoring. Finally, the results were compared with those yielded by the AI model. Results: The expression scoring model achieved a macro-averaged F1 score of 94% for TROP-2 and 91% for cMET. Moreover, the model demonstrated excellent concordance with expert pathologists (TROP-2: 93%; cMET: 95% average pair-wise Pearson correlation). TROP-2 overexpression was significantly higher in LUSC (mean H-score: 154.67) than LUAD (mean H-score: 86.57), while cMET showed the opposite trend (mean H-score LUAD: 59.52; LUSC: 25.68). Conclusion: This study highlights the potential of AI models to address key challenges in ADC biomarker evaluation, including expression heterogeneity, interobserver variability, and reduction in time expenditure. By successfully generalizing between TROP-2 and cMET, the model demonstrates adaptability and scalability for broader clinical applications. These findings pave the way for integrating AI into clinical workflows, improving patient stratification, and optimizing ADC therapy selection. Future efforts will focus on expanding this approach to additional biomarkers and validating its utility in prospective clinical trials. Citation Format: Philipp Anders, Philipp Erwin Seegerer, Katja Lingelbach, Suhas Pandhe, Sandip Ghosh, Cornelius Böhm, Stephan Tietz, Rosemarie Krupar, Lars Tharun, Marie-Lisa Eich, Julika Ribbat-Idel, Verena Aumiller, Sabine Merkelbach-Bruse, Alexander Quaas, Nikolaj Frost, Georg Schlachtenberger, Matthias Heldwein, Ulrich Keilholz, Khosro Hekmat, Jens-Carsten Rückert, Reinhard Büttner, David Horst, Maximilian Alber, Lukas Ruff, Frederick Klauschen, Gabriel Dernbach, Simon Schallenberg. From bench to bedside: generalizable AI model for ADC biomarker evaluation in NSCLC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 3351.

Abstract Introduction It has been our practice to send a sample of cerebrospinal fluid (CSF) for cytospin at the time of each lumbar puncture (LP) in children undergoing treatment for acute lymphoblastic leukaemia (ALL) in all the trials and treatment guidelines over the last 20 years at Alder Hey Children’s Hospital. A recent study has looked at the role of CSF surveillance in detecting silent CNS relapse in 331 children enrolled on UKALL 2003 who had completed treatment by May 2011 at Great Ormond Street and University College Hospital, London. The number of asymptomatic children with a positive CSF cytospin was divided by the total number of cytospins in the cohort revealing a detection rate of 0.09% (Samarasinghe et al 2012). In this respect we undertook a retrospective study at our institution to further examine the benefit of routine CSF cytology in patients with ALL. In particular, we aimed to determine the utility of CSF surveillance in detecting asymptomatic CNS relapse on treatment. Methods The medical records of all children diagnosed with ALL from 1992 onwards, and who had completed treatment by May 2013 were examined. CNS relapse was diagnosed if blasts were detectable on CSF cytocentrifuge (&gt;5/µL). Relapses were classified as symptomatic if they had signs suggestive of CNS leukaemia such as headache, diplopia or cranial nerve palsies and asymptomatic if such signs and symptoms were absent. Results 407 eligible patients were identified. There were 224 males and 183 females, with a median age of 6.5 years (range 2 months to 19 years). The subtype of ALL by immunophenotyping wad B lineage in 83%, T lineage in 12.25%, Philadelphia positive in 0.5%, null cell in 0.25% and subtype unknown in 4%. The cohort received treatment under a number of different UK protocols throughout the last 21 years as follows: 81 patients UKALL XI, 6 patients UKALL XI HR, 39 patients ALL 97, 9 patients ALL 97 HR, 83 patients ALL 97/99, 17 patients ALL 2003 MRD Pilot, 157 patients ALL 2003, 13 patients Interfant, 2 patients EsphALL. There were 90 relapses in 407 patients; 38 of these occurring in patients whilst on treatment. Seven out of these 38 relapses were CNS relapses – 5 isolated CNS relapse and 2 combined bone marrow and CNS relapse. Of these seven patients with CNS relapse on therapy, six had clear symptoms and signs of CNS relapse including headache (5 patients), vomiting (2 patients), and cranial nerve palsy (4 patients). Such symptoms or associated bone marrow disease would have prompted CSF cytology. Only one patient was diagnosed with asymptomatic CNS relapse on routine CSF examination, but this patient became symptomatic the following day with a facial nerve palsy. Six of these 7 patients with CNS relapse have since died; 5 following leukaemic relapse and 1 following lateral sinus thrombosis. Conclusions This retrospective study confirms the very low rate of detection of asymptomatic CNS relapse for patients receiving treatment for ALL. The benefit of routine CSF cytology i.e. at the time of intrathecal chemotherapy is thus very much drawn into question. We have thus changed practice and only undertake routine CSF cytology in the following situations: (1) at diagnosis in all patients, (2) throughout treatment in patients with CNS disease at diagnosis, (3) throughout treatment in patients treated on protocols for infant ALL and Philadelphia positive ALL. We do, however, recognise the need for a low threshold for performing an LP in any patient who shows signs or symptoms of CNS leukaemia. In summary, there appears to be little value in routine surveillance of CSF in the large majority of children and young people with acute lymphoblastic leukaemia. Disclosures: No relevant conflicts of interest to declare.

Abstract Background: Despite the rapidly increasing number of new targeted and immunotherapeutic options over the past two decades, the prognosis of patients with NSCLC, even with early-stage tumors, is still poor and novel biomarkers are needed to better stratify patients in terms of survival and treatment response. A novel approach is to gain a holistic understanding of the cellular composition and formation of the tumor microenvironment (TME). Therefore, we developed a miF-based, AI-driven approach for spatially resolved TME characterization at the cellular level and used this to successfully predict clinical outcome. Methods: We assembled a large bicentric real-world sample group of 1168 patients with resected NSCLC from the Charite and the University Hospital Cologne. For tissue microarray construction, four 1.5 mm tissue cores were punched from each formalin-fixed and paraffin-embedded tumor block. Sections were stained with a 12-plex IF panel followed by H&amp;E staining. All stains were scanned and co-registered with single cell accuracy. Next, we trained a H&amp;E-based tissue segmentation model to detect the different tumor regions: carcinoma, stroma, and necrosis. In addition, we developed a nucleus-based cell detection model, and 12 cell classification models to categorize each detected cell by single-miF channels. Different cell phenotypes were derived from the marker-specific cell classifications. Finally, we trained a model on the Charité cohort using the spatially resolved cell readouts, spot-wise phenotype log-density, co-clustering of marker expression, and frequency of co-occurrence of marker expression through Delaunay triangulation, to predict patient survival on the Cologne cohort. Results: The tissue segmentation model achieved a macro averaged F1 score of 92%. The cell detection model identified a total of 53 million cells that were classified marker-wise with an F1 score of at least 95% on hold-out data. Our final prediction model identified a stable spatially resolved cell signature, consisting of 10 different characteristic cell neighborhood niches, which could be used to predict overall patient survival. The model trained on the Charite cohort was validated with the Cologne cohort and achieved a high performance (C-score of 71). In comparison, the UICC8 stage and the immunoscore (CD20+CD3+/carcinoma cell ratio), which were used as a baseline, achieved C-scores of 63 and 54, respectively. Conclusions: The combination of our large real-world clinical cohort, multiplex panel, and automated AI approach enabled a broad spatially resolved exploration of the TME in NSCLC at single cell resolution. Our model identified a specific cell neighborhood signature predictive of patient survival outperforming the commonly used prognostic scores, UICC8 stage and immunoscore. This allows for an improved patient stratification with potential implication for therapy selection. Citation Format: Simon Schallenberg, Gabriel Dernbach, Sharon Ruane, Cornelius Böhm, Lukas Ruff, Kai Standvoss, Sandip Ghosh, Marco Frentsch, Mihnea Dragomir, Rebecca Fritz, Ines Koch, Corinna Friedrich, Il-Kang Na, Sabine Merkelbach-Bruse, Alexander Quaas, Nikolaj Frost, Kyrill Boschung, Winfried Randerath, Georg Schlachtenberger, Matthias Heldwein, Ulrich Keilholz, Khosro Hekmat, Jens Rückert, Reinhard Büttner, Angela Vasaturo, David Horst, Maximilian Alber, Frederick Klauschen. AI-driven, mIF-based cell-omics reveals spatially resolved cell signature for outcome prediction in NSCLC patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5222.

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Abstract Background: Minimal data exists for the utilization of the Oncotype Dx® assay specifically in breast cancers associated with BRCA1/2 pathogenic variants (PVs). It is unknown whether estrogen receptor positive (ER+) breast cancer associated with an inherited BRCA1 or BRCA2 (BRCA1/2) PV is more aggressive than disease seen in patients who do not carry an inherited PV, and whether there are differences between BRCA1 and BRCA2. In prostate cancer patients with inherited cancer predisposition due to a BRCA2 PV, more aggressive cancers are observed, which influences first-line treatment. Limited data exists for the optimal management of early stage ER+ breast cancer in BRCA1/2 PV carriers. Comparing Recurrence Score® (RS) results in ER+ breast cancer patients with an inherited BRCA1/2 PV (cases) versus matched patients who test negative for a PV in BRCA1/2 (controls) may inform whether biologically more aggressive breast cancer is seen in BRCA1/2 carriers and optimal treatment approaches. Methods: A retrospective case control study was performed to compare RS results in women with breast cancer with an inherited BRCA1/2 PV versus patients who tested negative for an inherited BRCA1/2 PV. Female breast cancer patients seen between 2005-2020 at NorthShore University Health System with ER+Her2- early stage invasive breast cancer with 0-3 lymph nodes who completed genetic testing for BRCA1/2 were eligible for enrollment. BRCA1/2 cases were defined as individuals with an inherited PV in BRCA1/2 and controls were negative for BRCA1/2 or other known breast cancer risk gene PVs tested. Subjects were excluded if they had neoadjuvant therapy (hormonal or cytotoxic chemotherapy). Eligible cases were matched to control patients by age, grade, and stage. The Recurrence Score result was obtained by chart review; if not previously evaluated, Oncotype Dx assay was performed by Exact Sciences. Statistical analysis of the primary outcome used the paired t-test to determine mean difference in RS results between BRCA1/2 PV carriers and patients negative for a PV in BRCA1/2 using a 1:1 matched pairs design. Results: A total of 46 matched cases and controls were analyzed. Median age was 50 with a range of 28-74. Of the cases, 18 had a BRCA1 PV and 28 had a BRCA2 PV. Cases and controls were well matched for age (&amp;gt; 50 and ≤ 50); race, grade, stage, and progesterone receptor status. As expected, a higher number of BRCA1/2 carriers were treated with mastectomy while more of the controls received breast-conserving surgery. Chemotherapy was utilized more frequently in the cases (67.4%) versus the controls (54.4%). The average RS result was higher in the cases (27) than the controls (21.3) by a mean difference of 5.7 (p = 0.0195). Using Oncotype Dx cutoffs of low &amp;lt; 18, intermediate 18-30 and high ≥ 31, a statistically significant difference in RS result was noted in the cases versus controls. For cases in the highest risk group (Oncotype Dx ≥ 31), only 20% of their matches also had a score in the highest risk group while 35% had a score in the lowest risk group. Subgroup analysis showed that the cases had the largest difference in RS result from their controls in premenopausal women (age ≤ 50), BRCA1 carriers, and the node negative population. Conclusion We present one of the largest data sets available to date of a well-matched cohort of cases and controls which shows that BRCA1/2 PV carriers are more likely to have a higher Recurrence Score result than their matched controls when matched for age, grade, and stage. These findings suggest ER+ breast cancer in BRCA1/2 PV carriers is biologically more aggressive. Further investigation is warranted to evaluate how this important finding impacts adjuvant therapy recommendations for BRCA1/2 PV carriers. Citation Format: Poornima Saha, Ashley Aller, Amanda Deliere, Peter Hulick, Katharine Yao, Kristine Kuchta, Megan Sullivan, Allison DePersia. Application of 21-gene Breast Recurrence Score® assay to evaluate prognosis and benefit of adjuvant chemotherapy in BRCA1 and BRCA2 pathogenic variant carriers with early stage, estrogen receptor positive breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-03-15.

Abstract Background: APOBEC mutagenesis underlies somatic evolution and accounts for tumor heterogeneity in several cancers, including BC. In our clinical experience, HR+HER2- BC with an APOBEC signature do poorly on standard of care (SOC) first line endocrine therapy (ET) + CDK4/6 inhibitor (CDK4/6i) and need additional treatment options. Here we evaluated the characteristics of a real-world cohort for time-to-treatment discontinuation (TTD) and overall survival (OS) on SOC and immune checkpoint inhibitors (ICI).Methods: Hybrid capture-based comprehensive genomic profiling (CGP) results from 29,833 formalin-fixed paraffin-embedded tissue biopsies of all BC subtypes were analyzed. For outcomes (TTD and OS), this study used a de-identified nationwide (US-based) BC clinico-genomic database (CGDB, ~800 sites of care, 1/2011 - 12/2020). HR+HER2- metastatic BC pts who received first line ET + CDK4/6i were included (CGDB cohort).TTD was defined as the difference between the first and last drug episode within a given line of treatment (LOT). LOT were derived based on FH algorithms. OS was defined as the time from LOT start to the date of death or data cutoff. Log-rank test and Cox model were used to evaluate the difference in outcomes. To reduce the impact of confounding variables (Age at Dx, Stage at Dx, Tumor Type, Metastases sites, TMB group (≥10 vs &amp;lt;10), SOC treatment group, PIK3CA), inverse probability of treatment weighting (IPTW) was used. Eligible pts from Mayo Clinic and Duke University were HR+HER2- mBC with sequencing data from FMI between 9/2013-7/2020. Clinical data were manually extracted from Mayo and Duke EHR. Results: Of all 29,833 BC samples in the CGP cohort, 7.9% were APOBEC+ with high rate in invasive lobular carcinoma (ILC) 16.7% vs. 4.9% in invasive ductal carcinoma (IDC) and metastatic lesions 9.7% vs. 4.3% from breast. APOBEC+ samples had a higher median TMB 12.5 vs. 2.5 mut/Mb. In CGDB, 857 HR+HER2- BC met inclusion criteria; 69 (8%) pts were APOBEC+ and 788 (9.2%) were APOBEC-. APOBEC+ pts had significantly shorter TTD on SOC ET+CDK4/6i than APOBEC- pts, 7.8 (95% CI 4.3-14.6) vs. 12.4 (95% CI 11.2-14.1) months (p=0.0036). APOBEC+ pts also had noticeably shorter OS compared to APOBEC- pts, 32.4 (95%CI 19.8-47.4) vs. 40.5 (95%CI 36.9-45.7) months (p=0.06).Cox regression results indicate that the relative risk of shorter TTD for the APOBEC+ vs the APOBEC- was 1.6 (95%CI 1.03-2.39). Also, APOBEC+ pts had almost twice the risk that APOBEC- pts had of death (HR=1.96, 95%CI 1.2-3.3). In CGDB, there were 10 APOBEC+ pts who received ICI, 9/10 had evaluable TTD data, 4/9 were still on treatment as of Dec 2020. 5/9 received ICI monotherapy, 4 pts received ICI + chemotherapy. TTD ranged from 0.3 to 11.3 mo, 1 pt’s TTD was &amp;gt; 6 mo. In Mayo and Duke cohort, there were 6 pts, 5/6 received ICI + chemotherapy. The TTD was 0.9-40.5 months with longest 2 pts receiving 5-FU plus ICI (11 and 40.5 months). To better understand the ICI treatment landscape, TTD in HR+HER2- hTMB MSS APOBEC- CGDB cohort (N=6) was analyzed: 5/6 had evaluable treatment data, 4/5 finished ICI treatment, 1 pt’s TTD was &amp;gt; 3 mo, 0/5 had TTD &amp;gt; 6 mo. Conclusions: APOBEC+ occurs in ~7% of BC and is more common in ILC and metastatic lesions. APOBEC+ HR+HER2- pts had shorter TTD and OS on SOC ET+CDK4/6i relative to APOBEC- pts. However, TTD on ICI tended to be longer in APOBEC+ pts, but our data is limited, and more research is needed. CGDB APOBEC+ vs. APOBEC- with SOC 1st lineAPOBEC+ (N=69)APOBEC- (N=788)p adjusted (FDR)*Age at Dx, Median (IQR)59.0 (53.0, 65.0)56.0 (47.0, 65.0)0.102Stage at Dx0.067- 0-III52 (75.4%)505 (64.1%)- IV11 (15.9%)245 (31.1%)- Not documented6 (8.7%)38 (4.8%)Metastasis free interval, yrs, Median (IQR)5.2 (3.0, 10.5)5.1 (2.8, 9.3)0.734Tumor Grade0.104- Grade 12 (2.9%)49 (6.2%)- Grade 234 (49.3%)259 (32.9%)- Grade 311 (15.9%)163 (20.7%)- Not documented22 (31.9%)317 (40.2%)Tumor Type0*- IDC7 (10.1%)251 (31.9%)- ILC30 (43.5%)138 (17.5%)- Other /Not documented32 (46.4%)399 (50.6%)Metastases sites0.734- Bone-only17 (24.6%)169 (21.5%)- CNS11 (15.9%)104 (13.2%)- Visceral41 (59.4%)514 (65.3%)TMB, Median (IQR)11.3 (8.8, 18.8)2.5 (1.3, 3.8)0*MSI0.946- MSI-H0 (0.0%)4 (0.5%)- MSI-I0 (0.0%)1 (0.1%)- MSS68 (98.6%)728 (97.2%)- Not documented1 (1.4%)16 (2.1%)BRCA5 (7.2%)45 (5.7%)0.734PIK3CA46 (66.7%)341 (43.3%)0.001*Treatments0.005*- AI + CDK4/6i31 (44.9%)510 (64.7%)- Fulvestrant + CDK4/6i38 (55.1%)278 (35.3%) Citation Format: Saranya Chumsri, Kira Raskina, Sarah Sammons, Laura Alder, Natalie Danziger, Alexa B Schrock, Kim McGregor, Ethan Sokol. APOBEC signature, clinical characteristics, and outcome in hormone receptor-positive (HR+) HER2-negative (HER2-) breast cancer (BC) patients (pts) in real-world data (RWD) [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD14-09.

This study aims to determine the procedure and to assess the quality of the development of test instruments in measuring the learning disabilities of elementary school students. Learning disabilities are formulated as disorders that occur in learning activities such as dyslexia, dysgraphia, dyscalculia. The type of the research is research and development by using Martini Jamaris’s Model. The subjects were 90 students of elementary school in Jakarta. The number of items was 75 items consisting of 19 items (dyslexia), 29 items (dysgraphia), and 27 items (dyscalculia). The results obtained in the validity test were declared valid were only 54 of the 75 items. Reliability of the test was stated to be reliable with very high interpretation in all dimensions. The results of the analysis of learning disabilities using a learning disabilities test that have been developed were obtained 90% of students experience learning disabilities.Abdurrahman, Mulyono. 2012. Anak Berkesulitan Belajar: Teori, Diagnosis, Dan Remediasinya. Jakarta: Rineka Cipta.Aiken, Lewis R., and Gary Groth-Marnat. 2005. Psychological Testing and Assessment. 12th ed. New Delhi: Pearson.Allen, K. Eileen, and Ilene S. Schwartz. 2001. The Exeptional Child Inclusion in Early Childhood Education. New York: Delmar.Aro, TuijaAhonen, Timo. 2011. Assessment of Learning Disabilities: Cooperation Beetween Teacher, Psychologists, and Parent. African ed. Finland: Suomen Yliopistopaino Oy – Uniprint.Aziz, Abdul. n.d. “Dataset Development of A Learning Disabilities Test: A Case Study at Elementary School.”Chodijah, Medina. 2014. “Model Bimbingan Kolaboratif Untuk Meningkatkan Kemampuan Akademik Anak Yang Mengalami Kesulitan Belajar (Learning Disabilities) Di Sekolah Dasar Inklusif.” Universitas Pendidikan Indonesia.Deiner, Penny L. 2013. Inclusive Early Childhood Education Development, Resources and Practice. 6th ed. USA: Wadsworth Cengage Learning.Dick, Walter, Lou Carey, and James O. Carey. 2015. The Systematic Design of Instructional. 8th ed. New York: Pearson Education Inc.Essa, Eva L. 2014. Introduction to Early Childhood Education. 7th ed. Canada: Thomson Learning Inc.Gall, Meredith D., Joyce P. Gall, and Walter R. Borg. 2003. “Educational Research: An Introduction.” Educational Research: An Introduction 683.Gephart, Harlan R. 2019. “Learning Problems in Children and Adolescents.” Pp. 9–15 in ADHD Complex.Gooch, Deanna L. 2012. “Research, Development, and Validation of A School Leader’s Resource Guide for The Facilitation of Social Media Use by School Staff.” Kansas State University.Harwell, Joan M., and rebecca W. Jackson. 2008. The Complete Learning Disabilities Handbook: Ready-to Use Strategies and Activities for Teaching Students with Learning Disabilities. 3rd ed. San Francisco: jossey-Bass.Heward, William L., Sheila R. Alber-Morgan, and Moira Konrad. 2017. Exceptional Children An Introduction to Special Education. 11th ed. New York: Pearson.Ifdil, Ifdil, Rima P. Fadli, Nilma Zola, Elfi Churnia, Yola Eka Putri, and Berru Amalianita. 2020. “The Effectiveness of Ifdil Perceptual Light Technique in Reducing Ophidiophobia.” Addictive Disorders &amp; Their Treatment 19(4):247–51.Jamaris, Martini. 2014. Kesulitan Belajar: Perspektif, Asesmen, Dan Penanggulangannya Bagi Anak Usia Dini Dan Usia Sekolah. Jakarta: Ghalia Indonesia.Jamaris, Martini, and Edwita. 2014. “Formal Multiple Intelligences Assessment Instruments for 4-6 Years Old Children.” American Journal of Educational Research 2(12):1164–74.Juntorn, Sutinun, Sarinya Sriphetcharawut, and Peeraya Munkhetvit. 2017. “Effectiveness of Information Processing Strategy Training on Academic Task Performance in Children With Learning Disabilities: A Pilot Study.” Occupational Therapy International.Kirk, Samuel, James J. Gallagher, Mary R. Coleman, and Nick Anastasiow. 2009. Educating Exceptional Children. 12th ed. Boston: Houghton Mifflin Harcourt Publishing Company.Klein, M. Diane, Ruth E. Cook, and Anne M. Richardson-Gibson. 2001. Strategies for Including Children With Special Needs in Early Childhood Settings. New York: Delmar.Leong, Han Ming, Mark Carter, and Jennifer R. Stephenson. 2015. “Meta-Analysis of Research on Sensory Integration Therapy for Individuals with Developmental and Learning Disabilities.” Journal of Developmental and Physical Disabilities 27(2):183–206.Maehler, Claudia, and Kirsten Schuchardt. 2016. “The Importance of Working Memory for School Achievement in Primary School Children with Intellectual or Learning Disabilities.” Research in Developmental Disabilities 58:1–8.Mangunsong, Frieda. 2014. Psikologi Dan Pendidikan Anak Berkebutuhan Khusus. 1st ed. Depok: LPSP3 UI. Mora, JNC; Silva, FB; Lopez, RR; Cortez, REC. 2016. “Design, Adaptation and Content Validity Process of a Questionnaire: A Case Study.” International Journal of Management 7(7):204–16.Mulyatiningsih, Endang. 2011. “Riset Terapan Bidang Pendidikan Dan Teknik.” 1–254.N Young, Sonia, and Karen Furgal. 2016. “Effectiveness and Implication of Sensory Integration Therapy on School Performance of Children with Learning Disabilities.” International Journal of Neurorehabilitation 03(01):17–18.Pesova, Biljana, Despina Sivevska, and Jadranka Runceva. 2014. “Early Intervention and Prevention of Students With Specific Learning Disabilities.” Procedia - Social and Behavioral Sciences 149:701–8.Post, Marcel W. 2016. “What to Do with ‘Moderate’ Reliability and Validity Coefficients?” Archives of Physical Medicine and Rehabilitation 97(7):1051–52.Sidiarto, Lily D. 2007. Perkembangan Otak Dan Kesulitan Belajar Pada Anak. Jakarta: UI Press.Smith, Catherine M. 1997. “Development of A Learning Disabilities Screening TesT for Adults.” University of Toronto.Smith, Tom E. C., Edward A. Polloway, Jamews R. Patton, and Carol A. Dowdy. 2008. Teaching Students with Special Needs in Inclusive Setting. 5th ed. New York: Pearson Educational Inc.Taherdoost, Hamed. 2016. “Validity and Reliability of the Research Instrument; How to Test the Validation of aQuestionnaire/Survey in a Research.” International Journal of Academic Research in Management 5(3):28–36.

e4008080Institutional Pedagogy is an educational proposal originated within the Freinet Movement in the late 1950s, which is anchored in psychoanalysis, taking the unconscious as a factor to be considered in important determinations of schooling processes, among which is the management of relational conflicts. Assuming the psychic conflict of desires and drives with cultural limits as motivation for learning, that pedagogy associates violence to the death drive, and understands the educational process as humanization within a culture that, at the same time, must regulate the deadly drives and value the vital ones, both inherent to the impulsive psychic life. It then is presented as a pedagogy of conflicts. Interpretating Freinet’s techinques and attentive to group processes, it develops some of its own devices (also called institutions), aiming at the development of verbal expression of thoughts and feelings, with the regulation of laws, places and limits that organize the pedagogical daily life and mediate horizontal and vertical relationships, in the classroom and at school taken as collectives, in the psychological and political sense of the term. Bruno Robbes, French pedagogue and professor at Cergy Paris University, is an expert in this current and, in this interview, deals with topics such as educational authority, the future of teaching as a profession, conflict management and the stress of education professionals related to that task, considering these themes from the interlocution between education and psychoanalysis, with an emphasis on the Lacanian perspective in which that Pedagogy is rooted.ResumoA Pedagogia Institucional é uma proposta educacional originada no seio do Movimento Freinet, no final dos anos 1950, que se ancora na psicanálise, tomando o inconsciente como fator a ser considerado nas determinações de importantes processos escolares, entre os quais está a gestão de conflitos relacionais. Presumindo que o conflito psíquico de desejos e pulsões com os limites culturais é motivador da aprendizagem, associa a violência à pulsão de morte e compreende o processo educacional como a humanização no seio de uma cultura que, ao mesmo tempo, deve regular o mortífero e valorizar o vital, ambos inerentes ao pulsional. Identifica-se, então, como uma pedagogia do conflito. Não só relendo técnicas do método Freinet, mas atenta a processos grupais, desenvolveu alguns de seus próprios dispositivos (também chamados instituições), voltados para o desenvolvimento da expressão verbal de pensamentos e sentimentos, com a regulação de leis, lugares e limites que organizam o cotidiano pedagógico e medeiam os vínculos horizontais e verticais, valorizando-se a turma e a escola como coletivos, no sentido psicológico e político do termo. Bruno Robbes, pedagogo e professor de Ciências da Educação na Universidade Cergy Paris, é especialista nessa corrente e, nesta entrevista, trata de temas como a autoridade educativa, o futuro do trabalho docente, o manejo de conflitos e o estresse de profissionais da educação a eles relacionado, discutindo estes temas a partir das interlocuções da educação com a psicanálise, com ênfase sobre a leitura que delas faz a teoria lacaniana, em cujos fundamentos essa Pedagogia está enraizada.ResumenLa Pedagogía Institucional es una propuesta educativa originada dentro del Movimiento Freinet a fines de la década de 1950, que está anclada en el psicoanálisis, considerando el inconsciente como determinante de importantes procesos escolares, entre los cuales el manejo de conflictos relacionales. Asumiendo que el conflicto psíquico de los deseos y los impulsos con límites culturales es motivador para el aprendizaje, asocia la violencia con la pulsión de muerte y entiende el proceso educativo como humanización dentro de una cultura que, al mismo tiempo, regular lo mortal y dar valor a lo vital, ambos inherentes al impulso. Así, se identifica como una pedagogía del conflicto. Interpretando las técnicas Freinet y atenta a los procesos grupales, desarrolló algunos de sus propios dispositivos (llamados instituciones), dirigidos al desarrollo de la expresión verbal de pensamientos y sentimientos, con la regulación de leyes, lugares y límites que organizan la vida pedagógica diaria y median las relaciones horizontales y verticales, valorando la clase y la escuela como colectivos, en el sentido psicológico y político del término. Bruno Robbes, pedagogo y profesor francés de la Universidad Cergy Paris, es un experto en esta tendencia y, en esta entrevista, aborda temas como la autoridad educativa, el futuro del trabajo docente, la gestión de conflictos y el respectivo estrés de los profesionales de la educación, discutiendo estos temas en función de las interlocuciones entre educación y psicoanálisis, con énfasis en la lectura que la teoría de Lacan, en cuyos fundamentos está arraigada esta pedagogía, hace de estas relaciones.Palavras-chave: Conflito e educação, Psicanálise, Pedagogia Institucional, Entrevista.Keywords: Conflict and education, Psychoanalysis, Institutional Pedagogy, Interview.Palabras claves: Conflicto y educación, Psicoanálisis, Pedagogía Institucional, Entrevista.ReferencesARDOINO, Jacques. Les avatars de l’éducation. Paris: PUF, 2000.ARDOINO, Jacques. Autorité. In: BARUS-MICHEL, Jacqueline; Enriquez, Eugène; Lévy, André. (Org.). Vocabulaire de psychosociologie: Positions et références. 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La “société de la connaissance”: généalogie d’une double réduction. Éducation et sociétés, v. 15, n. 1, p. 45-57, 2005.CANAT, Sylvie. Une autorité qui ne fait pas ses preuves… Empan, v. 63, n. 3, p. 66-78, 2006.CIFALI, Mireille. Partis pris entre théories et pratiques cliniques. In: CIFALI, Mireille; GIUST-DESPRAIRIES, Florence. (Org.). De la clinique: Un engagement pour la formation et la recherche. Bruxelles: De Boeck, 2006. Chapitre 7, p. 127-144.CIFALI, Mireille. Exigences d’une position clinique. Chemins de formation, n. 10/11, p. 68-75, 2007.CIFALI, Mireille. Une pensée affectée pour l’action professionnelle. In: CIFALI, Mireille; GIUST-DESPRAIRIES, Florence. (Org.). Formation clinique et travail de la pensée. Bruxelles: De Boeck, 2008, p. 129-147.CIFALI, Mireille; Imbert, Francis. Freud et la pédagogie. Paris: PUF. 1998.CIFALI, Mireille; Moll, Jeanne. Pédagogie et psychanalyse. Paris: Dunod, 1985.CIFALI, Mireille. Préserver un lien. Éthique des métiers de la relation. Paris: PUF, 2019.DARCOS, Xavier; MEIRIEU, Philippe. Deux voix pour une école. Paris, França: Desclée de Brouwer, 2003.DE GAULEJAC, Vincent. La société malade de la gestión: idéologie gestionnaire, pouvoir managérial et harcèlement social. Paris: Éditions du Seuil, 2009.DE GAULEJAC, Vincent. Travail, les raisons de la colère. Paris: Éditions du Seuil, 2011.DEJOURS, Christophe. Le choix: Souffrir au travail n’est pas une fatalité. Paris: Bayard, 2015.DE VECCHI, Gérard. Former l’esprit critique: Pour une pensée libre. Paris: ESF, 2016. v. 1.FAVRE, Daniel. Éduquer à l’incertitude – Élèves, enseignants: comment sortir du piège du dogmatisme? Paris: Dunod, 2016.FILLOUX, Jean-Claude. Psychanalyse et pédagogie: Ou d’une prise en compte de l’inconscient dans le champ pédagogique. Revue française de pédagogie, Paris, nº 81, p. 69-102, 1987.FRANÇA. Ministère de l'Éducation Nationale et de la Jeunesse. Déconstruire la désinformation et les théories conspirationnistes. França, 2019. Disponível em: https://eduscol.education.fr/cid95488/deconstruire-la-desinformation-et-les-theories-conspirationnistes.html%20;%20http://www.gouvernement.fr/on-te-manipule. Acesso em: 10 jan. 2020.FREUD, Sigmund (1933). Nouvelles conférences d’introduction à la psychanalyse. Paris: Gallimard, 1984.GEFFARD, Patrick. Fernand Oury et la P.I. Disponível em: http://pig.asso.free.fr/Fernand_Oury.htm. Acesso em: 10 jan. 2020.HOUSSAYE, Jean. La Pédagogie traditionnelle: une histoire de la pédagogie. Paris: Fabert, 2014.IMBERT, Francis. L’inconscient dans la classe. Paris: ESF, 1996.IMBERT, Francis. Imaginaire et symbolique. Repères pour des enseignants. In: PICQUENOT, Alain (coord.). Il fait moins noir quand quelqu’un parle: Éducation et psychanalyse aujourd’hui. Dijon: SCÉREN-CRDP de Bourgogne, 2002, p. 151-158.IMBERT, Francis. Vocabulaire pour la pédagogie institutionnelle. Vigneux: Matrice. 2010.JEFFREY, Denis. Crise de l’autorité et enseignement. 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Acesso em: 09 jan. 2020.MEIRIEU, Philippe. Le maître, serviteur public. Sur quoi fonder l’autorité des enseignants dans nos sociétés démocratiques? Conférence donnée dans le cadre de l’école d’été de Rosa Sensat, Université de Barcelone, Julho de 2008. Disponível em: http://meirieu.com/ARTICLES/maitre_serviteur_public.htm. Acesso em: 08 jan. 2020.OURY, Fernand; POCHET, Catherine. Qui c’est l’Conseil? Paris: Maspéro, 1979.PAIN, Jacques. La violence institutionnelle? Aller plus loin dans la question sociale. Cahiers critiques de thérapie familiale et de pratiques de réseaux. Paris, v. 1, nº 24, p. 133-155, 2000.PETITOT, Françoise. De l’enfant-roi à l’enfant-victime: l’enfant oublié. In: GAVARINI, Laurence; LEBRUN, Jean-Pierre; PETITOT, Françoise. Avatars et désarrois de l’enfant-roi. Paris: Fabert, 2011, p. 11-24.POCHET, Catherine; OURY, Fernand; OURY, Jean. L’année dernière, j’étais mort… signé Miloud. Vigneux: Matrice, 1986.REY, Bernard. Autorité et relation pédagogique. In: CHAPPAZ, Georges. L’autorité en pannes… Entre besoin de soumettre et désir d’éduquer. Aix-Marseille: Université de Provence, 2004a, p. 113-128.REY, Bernard. Discipline en classe et autorité de l’enseignant: eléments de reflexión et d’action. Bruxelles: De Boeck, 2004b.REY, Bernard. Autour des mots “compétence” et “compétence professionnelle”. Recherche et formation, v. 60, p. 103-106, 2009.ROBBES, Bruno. Comment aborder concrètement la question de la sanction dans un cours de morale? Rev. Diotime – Revue Internationale de didactique de la philosophie, v. 61, julho de 2014. Disponível em: http://www.educ-revues.fr/DIOTIME/AffichageDocument.aspx?iddoc=99877. Acesso em: 06 jan. 2020.ROBBES, Bruno. L’autorité enseignante. Approche clinique. Nîmes: Champ social, 2016.ROBBES, Bruno. A pedagogia institucional na França e no Brasil: disciplina escolar, autoridade e o manejo. In: ANDRADE, Fernando Cézar Bezerra de; BURITY SERPA, Marta Helena; GONZAGA, Katherinne Rozy Vieira (Orgs.). 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Wild reindeer in Norway, presently (winter 2005-06) numbering some 25 000 animals, are found in 23 more or less separated areas in the mountainous southern part of the country (see map in appendix). All herds are hunted and management is organized in close cooperation between owner organizations and state agencies. I will provide a historical review of the wild reindeer management and research in Norway and conclude with the present situation. We identify 3 types of wild reindeer on basis of their origin: (1) the original wild reindeer with minor influence from previous domestic reindeer herding activities (Snøhetta, Rondane and Sølenkletten), (2) wild reindeer with some influx of animals from past domestic reindeer herding in the area (Nordfjella, Hardangervidda, Setesdal-Ryfylke) and (3) feral reindeer with a domesticated origin (reindeer released or escaped from past reindeer husbandry units; Forolhogna, Ottadalen North and Ottadalen South, Norefjell-Reinsjøfjell and several smaller areas). In Norway, genetic origin (wild or domesticated), body size and reproductive performance of reindeer differ among areas. Feral reindeer have higher body weights and enjoy higher reproductive rates than their originally wild counterparts. These differences may partially be explained by differences in food quality and availability among the populations. However, there is a growing suspicion that other explanatory factors are also involved. Wild reindeer are more vigilant and show longer fright and flight distances than feral reindeer. Number of animals harvested was 4817, or ca. 20% of the total population in 2005, but varies between 40% in feral reindeer areas to below 20% in some of the "wild" reindeer areas. Causal factors behind this variation include differences in age at maturation, postnatal calf mortality and herd structure. The Norwegian Institute for nature research (NINA) in cooperation with the Directorate for nature management (DN) allocate considerable resources to monitoring 36 wild reindeer herds and pastures, especially winter pastures. A total of 8 wild reindeer areas are monitored annually (the monitoring program was initiated in 1991), recording calf recruitment rates in nursery bands in June/July from aerial photographs and herd composition from ground counts of rutting groups in September/October. Carcass weights and mandibles are sampled at regular intervals from harvested animals in the same areas in order to investigate reindeer body weight development. The botanical part of the monitoring program is concentrated on renewal growth of lichen in areas under variable reindeer grazing pressure, and annual measurements of radiocesium load in plants and reindeer meat from fall-out areas following the Chernobyl accident in 1986. Reindeer research relating to the wild reindeer herds in southern Norway is mainly conducted by NINA in Trondheim and the Biology Institute, University of Oslo. Most mountain ranges and wild reindeer populations in Norway are experiencing an increase and expansion of human use, including infrastructure such as road and power-lines, and private cabins, tourism/recreation, etc. Present research activities focus on wild reindeer area use, behaviour and activity budgets in selected areas on a 24 hour and a seasonal basis by use of GPS-technology. An important part of the ongoing projects emphasizes a close monitoring and investigation of reindeer behaviour and activity in relation to human activities and infrastructure. Furthermore, development and quality control of methods for measurement of response towards anthropogenic activities and population reproduction and early calf mortality are included in the research activities.Villrein i Norge; Populasjonsøkologi, forvaltning og jaktAbstract in Norwegian / Sammendrag: Villreinen i Norge utgjør i 2005-06 en vinterbestand på ca. 25 000 dyr fordelt på 23 stort sett isolerte villreinområder (kart i appendiks) som jaktelig sett forvaltes enkeltvis og i et samarbeid mellom rettighetshavere og statlige forvaltningsorganer. Presentasjonen gir en historisk fremstilling av villreinforvaltningen i Norge og den forskningsutvikling som ligger bak dagens situasjon. Vi har 3 typer villrein i Norge: (1) den opprinnelige med liten tamreininnblanding karakterisert ved områdene Snøhetta, Rondane og Sølenkletten, (2) villrein med varierende innslag av tamreinpåvirkning (Nordfjella, Hardangervidda, Setesdal-Ryfylke) og (3) villrein med tamreinopphav (dvs. forvillet tamrein; Forolhogna, Ottadalen Nord og Ottadalen Syd, Norefjell-Reinsjøfjell og en rekke mindre områder). Reinens kroppsvekter i kategori 3-områdene er vesentlig høyere enn de i kategori 1 og 2. Forskjeller i beiteforhold områdene i mellom er nok medvirkende årsak, men adferdsundersøkelser som omfatter vaktsomhetsadferd og frykt- og fluktadferd i ulike områder tyder på at vaktsomhet og aktivitetsmønster kan være andre viktige påvirkningsfaktorer. Avkastningen i form av felte dyr var i 2005 ca. 20% av samlet vinterbestand, men varierer mellom 40% i områder der kroppsvektene er store til under 20% der reinen har lavere kroppsvekter. Forklaringsfaktorer omfatter forskjeller knyttet til alder for kjønnsmodning og reproduksjon, postnatal kalvedødlighet og kjønns- og alderssammensetning i de ulike villreinområdene. Norsk villreinforvaltning i regi av Norsk institutt for naturforskning (NINA)/Direktoratet for naturforvaltning (DN) satser store ressurser på overvåkning av villrein og deres beiter, særlig vinterbeiter. Til sammen 7 spesielt utvalgte villreinområder overvåkes årlig (start 1991) med flyfotografering av fostringsflokker i juni/juli for å bestemme kalvetilvekst og bakkeregistreringer om høsten for å bestemme bestandsstruktur. Med jevne mellomrom innsamles også kjever og slaktevekter fra høstjakten for å vurdere reinens kondisjonsutvikling i overvåkningsområdene. I den botaniske del av overvåkningsaktivitetene måles gjenvekst av lav i områder utsatt for vekslende beitepress og radiocesiumbelastningen etter Tsjernobylulykken i 1986 i næringsplanter og i kjøttprøver fra felt villrein i de områdene som ble hardest rammet av nedfall. Villreinforskningen er særlig lokalisert til NINA og Universitetet i Oslo. Forskningsaktivitetene omfatter måling av reinens adferd og aktivitet gjennom døgnet og dyrenes sesongmessige områdebruk i relasjon til menneskelig infrastruktur i utvalgte områder ved hjelp av bl.a. GPS-instrumentering og utvikling og kvalitetskontroll av metodeverktøy til bestemmelse av reproduksjon og tidlig kalvedødlighet.

Введение.Минеральная часть почвы, на долю которой приходится 80–90 % общей массы, оказывает большое влияние на её физические, водные и агрохимические свойства, определяя структуру биогеоценозов, их производительность и закономерности развития, являясь для растений источником питательных веществ. Знания о процессах изменения элементного состава почв под воздействием естественных и антропогенных факторов необходимы для глубокого понимания их генезиса, а также особенностей протекания в экотопах биологического круговорота веществ. Цель исследования – оценка валового содержания химических элементов в почвах пойменных экотопов бассейна реки Малая Кокшага Республики Марий Эл, выявление границ и закономерностей его изменчивости. Объекты и методы. Исследования проведены в шести пойменных и одном приводораздельном экотопах, последний из которых служил эталоном сравнения. Оценку валового содержания химических элементов в почве проводили с помощью рентгенофлуоресцентного анализа в институте геологии и нефтегазовых технологий Казанского (Приволжского) федерального университета. Полученный цифровой материал обработан на ПК с использованием методов математической статистики. Результаты. В образцах почвы было выявлено наличие 30 химических элементов, преобладающим из которых является Si. На порядок меньше содержится в них Al и Fe, а за ними следуют K, Mg, Na и Ca. Кларки концентрации наиболее велики у Cu, Zr, Cr, Ni и Mn, несколько повышены они у V и Ti. Среднее значение кларка концентрации Zn, Fe и Al близко к единице, а у Si, Mg и Ba оно изменяется от 0,88 до 0,78. Самые низкие кларки концентрации у Na(0,38), Ca(0,31) и S(0,27). Установлено, что по мере развития почв в них чётко возрастает содержание органического вещества, Mn, P и S, а концентрация же Al и Mg, наоборот, снижается. Содержание остальных химических элементов в процессе эволюции почв практически не меняется. В краткопойменных экотопах под пологом всех древостоев, за исключением сероольшаника, изменения состава почв протекали практически так же, как и в нагорном липняке. Наиболее значительные изменения элементного состава почв произошли на пойменном лугу. Вывод. Особенности эволюции почв лучше всего отражает изменение валового содержания в них фосфора, серы и марганца, тесно связанного с органическим веществом, а также железа, характеризующего особенности протекания окислительно-восстановительных процессов. The mineral part of the soil, which accounts for 80-90 % of the total mass, has a great influence on its physical, water and agrochemical properties, determining the structure of biogeocenoses, their productivity and development patterns, and serving as a nutrient for plants. Knowledge of the processes of change in the elemental composition of soils affected by natural and anthropogenic factors is essential for in-depth understanding of soil genesis and peculiarities of the biological cycle of substances in ecotopes. The purpose of the research is to assess the gross content of chemical elements in the soils of bottomland ecotopes of the Malaya Kokshaga river basin of the Republic of Mari El, as well as determine the limits and patterns of its variation. Objects and methods. The studies were carried out in six bottomland ecotopes and one near-watershed ecotope, the latter served as a benchmark for comparison. Assessment of the gross content of chemical elements in the soil was performed by means of X-ray fluorescence analysis conducted at the Institute of Geology and Petroleum Technologies of Kazan (Volga Region) Federal University. The digital materials obtained were processed on a PC using methods of mathematical statistics. Results.The soil samples exhibited the presence of 30 chemical elements, among which Si prevailed. They also contain an order of magnitude less Al and Fe, followed by K, Mg, Na and Ca. The clarkes of concentration are the highest for Cu, Zr, Cr, Ni and Mn; they are slightly increased for V and Ti. The average clarke value of Zn, Fe and Al concentration is close to 1, and for Si, Mg and Ba it varies from 0.88 to 0.78. The lowest clarkes were observed for Na (0.38), Ca (0.31) and S (0.27) concentration. It was found that with the soil evolution, the content of organic matter, Mn, P and S in soils steadily increases, while the concentrations of Al and Mg, on the contrary, decrease. The content of other chemical elements remains essentially unchanged in the process of soil evolution. In the ecotopes of bottomland subject to short-term flooding, under the canopy of all forest stands with the exception of gray alder forests, alterations in the soil composition proceeded in almost the same manner as in the upland lime-tree forests. The most significant changes in the elemental composition of soils occurred in the floodplain meadow. Conclusion. Particularities of the soil evolution are best reflected in the changes in the gross content of phosphorus, sulfur and manganese in soils, which is closely related to organic matter, as well as the gross content of iron, characterizing the specificity of redox processes.

In der Medienpädagogik ist es erklärtes Ziel, allen gleichermaßen Mediennutzung zu ermöglichen, Medienkompetenz in allen räumlichen, sozialen und generativen Bereichen zu verankern, soziale und politische Teilhabe für alle zu ermöglichen. Gerade Neue Medien bieten dazu wertvolle Möglichkeiten, auch jenen Menschen Teilhabe zu ermöglichen, die sonst Gefahr laufen, an Barrieren zu stoßen und gegebenenfalls daran zu scheitern. Seien es ältere Menschen oder Menschen mit Migrationshintergrund, Menschen mit niedriger formaler Bildung oder Menschen mit Behinderung. Letztere wurden lange Zeit dennoch als ‚Sonderfall‘ angesehen und standen selten im Fokus medienpädagogischer Bemühungen. Doch in jüngster Zeit finden sie zunehmend Beachtung. Immer wieder fällt dabei in (medien-)pädagogischen Diskursen das Stichwort ‚Inklusion‘. Kinder mit und ohne Behinderungen in gemeinsamen Klassen, inklusiven Krippen, Horten, Betreuungsangeboten. (Mediale) Werkzeuge, die gemeinsames, inklusives Lernen und Arbeiten erleichtern oder ermöglichen, werden zunehmend diskutiert und auch in die Praxis umgesetzt.Ein Katalysator war dabei sicher die Verabschiedung der Behindertenrechtskonvention (BRK) der Vereinten Nationen im Dezember 2006, die seit März 2009 auch für Deutschland verbindlich ist. Sie machte erstmals deutlich, dass die Grund- und Menschenrechte auch für Menschen mit Behinderungen uneingeschränkt Geltung haben – auch und gerade, wenn es um gesellschaftliche und politische Teilhabe geht. So fordert die Konvention unter anderem klar das Recht auf uneingeschränkte Teilhabe an der Informationsgesellschaft, an mediatisierten Welten und an der Kommunikationskultur. Dabei stehen zwei zentrale Forderungen im Vordergrund: - Auf gesellschaftlicher Ebene soll Menschen mit Behinderung eine echte und wirksame Teilhabe ermöglicht werden. Es geht darum, „den vollen und gleichberechtigten Genuss aller Menschenrechte und Grundfreiheiten durch alle Menschen mit Behinderungen zu fördern“ (UN Behindertenrechtskonvention – Artikel 1).- Für die Einzelnen bedeutet Partizipation auch zugleich Selbständigkeit. Es muss allen Menschen möglich sein, mit ihren selbst verfügbaren persönlichen, materiellen und sozialen Kräften zur eigenen Lebensqualität beizutragen und diese zu gestalten.Beide Forderungen setzen in Bezug auf Medienpädagogik zunächst Chancengerechtigkeit voraus. Menschen mit Behinderung müssen die Möglichkeit haben, barrierefrei an Medienbildung zu partizipieren. Dies betrifft die Nutzung von Medien, aber auch die Möglichkeit, an allen Angeboten der Medienpädagogik teilzuhaben. Diese grundsätzlichen Forderungen der UNKonvention sind seitdem viel diskutiert worden und finden immer stärkeren Anklang und immer breitere Umsetzung. Viele Organisationen und Institutionen, die sich von jeher mit Menschen mit Behinderung beschäftigen, haben sich die Ideen der Konventionen zu eigen gemacht und versuchen, ihre Umsetzung voranzutreiben bzw. Hilfestellungen zur Umsetzung zu liefern. Genannt sei etwa die Caritas, die auf ihrer Homepage ein ausführliches, praxisorientiertes Handbuch Inklusion zum Download anbietet oder die Deutsche UNESCO-Kommission, die in ihrer Hauptversammlung 2011 ebenfalls eine Resolution zur Inklusiven Bildung verabschiedete.Doch auch Forschung und Praxis, die nicht in erster Linie Menschen mit Behinderung im Blick haben, werden mehr und mehr darauf aufmerksam. Veranstaltungen wie die Fachtagung All inclusive? Informationskompetenz und inklusive Mediengesellschaft, die am 30. November 2011 in Düsseldorf stattfand oder die Tagung Anschluss statt Ausschluss. (Inklusive) Medienbildung an Förderschulen und im gemeinsamen Unterricht (www.anschluss-statt-ausschluss.tudortmund.de), die am 23. März 2012 an der TU Dortmund stattfinden wird, zeigen dies. Inklusion in Theorie und Praxis – Die Texte in diesem Heft In dieser Ausgabe der merz | medien + erziehung möchten wir dieses aktuelle Thema aufgreifen und einen Blick auf die Anforderungen und Ziele werfen, aber auch die Erfolge betrachten, die bereits verzeichnet werden können.Um den viel diskutierten Begriff ‚Inklusion‘ einführend zu klären und auch von ‚Integration‘ abzugrenzen, eröffnet Hildegard Mogge-Grotjahn von der Evangelischen Fachhochschule in Bochum das Thema mit einer Begriffsklärung und -einordnung. Dabei beschäftigt sie sich sowohl mit der Herkunft des Begriffes als auch mit gängigen Fehldeutungen und Fehlanwendungen und legt so die Grundlage des Begriffsverständnisses für das Heft.Jan-René Schluchter von der Pädagogischen Hochschule Ludwigsburg gibt daran anschließend eine ausführliche Einführung in den Themenkomplex ‚Inklusion und Medienpädagogik‘ und erläutert, welche Aufgaben Medienpädagogik im Rahmen inklusiver Bemühungen zufallen, welche Anforderungen sich stellen und auch, wo sich Grenzen auftun.An diese theoretischen Grundlagen anschließend beschäftigen sich zwei Autoren mit spezielleren Fragestellungen der inklusiven Medienpädagogik:Christopher Mihajlovic, Pädagogischer Mitarbeiter in der Ambulanten Familienhilfe der Lebenshilfe e. V. in Frankfurt am Main stellt eine Lehrerbefragung zum Einsatz von Computern und Internet an Förderschulen vor und zeigt dabei, dass Neue Medien hier deutlich häufiger und intensiver eingesetzt werden, als dies an Regelschulen der Fall ist, dass zwischen den verschiedenen Medien(-angeboten) aber dennoch teilweise große Unterschiede in der Nutzbarkeit und Anwendung klaffen. Florian Lock präsentiert anschließend eine umfassende Inhaltsanalyse der Zeitschrift Der Spiegel, für die er Studien von 1955 bis 2005 zugrunde legt sowie eine eigene Untersuchung anstellt, die umfassend darlegt, wie Menschen mit Behinderung im Spiegel dargestellt wurden bzw. werden. Dabei zeigt er, dass Aspekte wie die Schwerpunktsetzung bei der thematischen Einbettung und der Schreibstil recht ähnlich geblieben sind, kann aber dennoch einen Wandel in der Sichtweise auf Menschen mit Behinderung feststellen.Die theoretischen und empirischen Artikel zum Thema Inklusion werden auch in diesem Heft ergänzt und weitergeführt durch kurze Vorstellungen bereits existierender, praktischer Projekte.So beschreibt Ingo Bosse Konzeption, Umsetzung und Evaluation von Computerkursen in Wohnheimen von Bethel Regional für Erwachsene mit hohem Hilfebedarf, Carola Werning und Diana Stuckatz schildern ihre Erfahrungen aus Kooperationsprojekten der LAG Lokale Medienarbeit NRW e. V. und der tjfbg gGmbH, Vera Tillmann beschäftigt sich mit inklusiven Bewegungs- und Sportmöglichkeiten mit der Spielkonsole Wii und Elisabeth Jäcklein-Kreis stellt das Magazin TOLL vor, das von Menschen mit Behinderung gestaltet und teilweise produziert wird.Wer nach all diesen theoretischen und praktischen Beiträgen immer noch Wissensdurst zum Thema verspürt, der findet auf der nächsten Seite zudem eine kurze Literaturliste mit interessanten, informativen und hilfreichen Lese- und Klickempfehlungen.Wir wünschen viel Spaß beim Lesen und eine anregende Lektüre. Literatur zum Thema ‚Medienpädagogik und Inklusion ‘Jan-René Schluchter (2010). Medienbildung mit Menschen mit Behinderung. Schriftenreihe Medienpädagogische Praxisforschung Band 5. München: kopaed.Theoretisch-konzeptionelle Grundlagen zur Medienpädagogik mit Menschen mit Behinderung. Für zehn thematische Schwerpunkte im Schnittfeld ‚Behinderung‘ und ‚Medien‘ werden Themen und Ansatzpunkte für die praktische Arbeit herausgearbeitet.Lani, Florian/Hegarty, John (2004). ICT and Special Educational Needs: A Tool for Inclusion.London: Open University press.Umfangreiches, englischsprachiges Herausgeberwerk, das die Chancen und Grenzen des Einsatzes neuer Medien in der pädagogischen Arbeit mit Menschen mit Behinderung erläutert und dabei schulische sowie außerschulische Ansätze vermittelt.Diözesan.Caritasverband für das Erzbistum Köln: Handbuch Inklusion. Teilhabe von Menschen mit Behinderung im Alltag. http://blog.kein-mensch-ist-perfekt.de/wp-content/uploads/2010/12/Handbuch_inklusion_koeln.pdf Ausführliches, informatives Handbuch mit Begriffsklärungen, theoretischen Grundlagen und umfassenden praktischen Informationen und Tipps zur Inklusion, aufgegliedert nach verschiedenen Behinderungen und Zielgruppen. Ergänzt um Literaturtipps.Mekonet Handreichung. Inklusive Medienbildung auf einen Blick. www.mekonet.deSechsseitige Broschüre mit Informationen zu Inklusion und Medienbildung und vielen interessanten Links.LAG Medien NRW: www.inklusive-medienarbeit.deDarstellung eines Modellprojektes zur Umsetzung einer inklusiven Medienpädagogik in Nordrhein-Westfalen sowie weitere Informationen und Links.www.einfach-teilhaben.deDas Webportal für Menschen mit Behinderungen, ihre Angehörigen, Verwaltungen und Unternehmen; mit praktischen Tipps und Informationen zu allen Lebensbereichen und -fragen.www.einfach-fuer-alle.deInitiative der Aktion Mensch für ein barrierefreies Internet http://meldestelle.di-ji.de Meldestelle für digtiale Barrieren http://ftb-esv.de Forschungsinstitut Technologie und Behinderung der ev. Stiftung Vollmarstein www.barrierefrei-kommunizieren.de Berufliche und gesellschaftliche Integration von Menschen mit und ohne Behinderung mit Hilfe moderner Informations- und Kommunikationstechnologien (IKT)www.anschluss-statt-ausschluss.tu-dortmund.deÜbersicht über zahlreiche Praxis- und Forschungsprojekte

The article describes two of the most prominent open access expériences in Algeria.It also is a bird's eye view of the open access movement in Algeria and its incidence on scientific research in general in Algeria

Abstract This article examines competing economic theories of crime and punishment within a common analytical framework. The theories—due to Becker (1968. “Crime and Punishment: An Economic Approach,” 76 Journal of Political Economy 169–217), Posner (1985. “An Economic Theory of the Criminal Law” 85 Columbia Law Review 1193–231), and Adelstein (1981. “Institutional Structure and Evolution in the Criminal Process,” 76 Northwestern University Law Review 1–99)—share the view of crime as exchange, but differ in the interpretation of punishment; specifically, is it aimed at pricing crime, preventing crime, or achieving corrective justice? The hybrid model used to address this question, originally developed by Hylton (2005. “The Theory of Penalties and the Economics of Criminal Law,” 1 Review of Law and Economics 175–201), explicitly incorporates market exchange as an alternative to criminal exchange. The results show that the optimal enforcement policy generally involves maximal punishment (however that is defined), but the optimal probability of apprehension can be high or low, depending on the parameters of the model. In the latter case, crime may completely crowd out the market. (JEL K14, K42)

Abstract On behalf of the ICFAES 2021 organizing committee, I am honored and delighted to welcome you to the 3rd International Conference on Fisheries, Aquatic and Environmental Science (ICFAES). The implementation of 3 ICFAES which should have been carried out in 2020, had to be postponed until this year, due to the new pandemic outbreak. However, because of the cooperation and support of all parties, this year, we are proudly implemented the 3rd International Conference on Fisheries, Aquatic and Environmental Science (ICFAES) 2021 by virtual from Aceh Province, Indonesia and offline from Nanning city, Guangxi province, China. The 3rd International Conference on Fisheries, Aquatic and Environmental Science (ICFAES) was held virtually. This is due to the pandemic states of COVID-19 in Indonesia and the increase of cases number in Aceh Province especially. Therefore, the Rector of Syiah Kuala University has released a protocol that all academic activities should arrange virtually or by an online platform. The policy of 14-days quarantine also urges this symposium conducted virtually. For your information, our ICFAES 2021 recorded program has been published via online video platform (Youtube: ICFAES 2021). Our technical program is rich and varied with 3 keynote speech namely Prof Mazlan Abd Gaffar, University Malaysia Terengganu, Malaysia, Prof Junichi Tanaka, Ryukyus University, Japan and Prof. Yushinta Fujaya, Hasanudin University, Indonesia and 11 invited talks and around 94 technical papers from different countries like United Kingdom, Japan, China, Saudi Arabia, Bangladesh, Malaysia, and Indonesia split between 5 parallel oral sessions and 5 poster sessions (flash presentation) in one day. We also provided technical sharing from industries namely Mr. Almer Havis Sandy from Yamaco Pacific/PT. Yakin pacific Tuna and numerous informal networking. List of Committees, Documentation ICFAES 2021 are available in this pdf.

This article presents the results of an experimental study on the practice of extensive listening strategy (EL) for the third-year students at the Faculty of Tourism, Dalat University, when studying the course of English for Specific Purposes (ESP) “English for Tourism 2”. The students of the experimental group spent eight weeks conducting searching listening materials, listening outside the classroom independently and with their team, taking weekly listening tests designed by other teams before taking the final listening test; the results of which would be used to compare with the English listening results of the control group performing traditional listening practice activities. The results of the final listening test, survey and interview responses revealed a statistically significant positive correlation between the application of EL during the course period with the English listening competence of the students, researchers also investigated the perception of these students about the application of this listening strategy. This study implies improvements in the design for future implementations of EL, including the length of practising EL activities and the enhancement of students participation in these listening activities&#x0D; Keywords&#x0D; English for Specific Purposes (ESP); Extensive listening (EL); Listening skills&#x0D; References&#x0D; 1. Bruce, I., Introduction to EAP: Key issues and concepts, in Theory and concepts of English for academic purposes2011, Palgrave Macmillan: Hampshire, UK. p. 3-14.2. Field, J., Special issue: Listening in EAP. Journal of English for academic purposes, 2011. 10(2): p. 73-78.3. Beall, M.L., et al., State of the context: Listening in education. International journal of listening, 2008. 22: p. 123-132.4. Bommelje, R., J.M. Houston, and R. Smither, Personality characteristics of effective listeners: A five factor perspective. International Journal of Listening, 2003. 17: p. 32-46.5. Conaway, M.S., Listening: Learning tool and retention agent., in Improving reading and study skills, A.S. Algier and K.W. Algier, Editors. 1982, Jossey-Bass: San Francisco, CA. p. 51-63.6. Ridgway, T., Listening strategies - I beg your pardon? ELT Journal, 2000. 54(2): p. 179-185.7. Brown, S., Teaching listening2006, Cambridge, England: Cambridge University Press.8. Ediger, M., Listening in the integrated curriculum. Reading Improvement, 2012. 49(1): p. 3-5.9. Richards, J.C. and R. Schmidt, Longman dictionary of language teaching and applied linguistics. 3rd ed2002, Harlow, England: Pearson Education Ltd.10. Bruce, I., The EAP and teaching the listening skill, in Theory and concepts of English for academic purposes2011, Palgrave Macmillan: Hampshire, UK. p. 154-176.11. Flowerdew, J. and L. Miller, in Second language Listening: Theory an practice2005, Cambridge University Press: Cambridge, England.12. Harmer, J., Listening., in The practice of English language teaching2007, Pearson Education: Essex, England. p. 303-322.13. Thiele, A. and G. Scheibner-Herzig, Listening comprehension training in teaching english to beginners. System, 1983. 11(3): p. 277-286.14. Chang, A.C.S., Gains to L2 listeners from reading while listening vs. listening only in comprehending short stories. System, 2009. 37(4): p. 652-663.15. Brett, P., A comparative study of the effects of the use of multimedia on listening comprehension. System, 1997. 25(1): p. 39-53.16. Brown, R., Extensive listening in English as a foreign language. Language Teacher, 2007. 31: p. 15.17. Ferrato, T. and M. White, Ring the bell - It's time for EL! ETJ Journal, 2009. 20: p. 20-21.18. Siegel, J., Thoughts on L2 listening pedagogy. ELT Journal, 2011. 65(3): p. 318-321.19. Harmer, J., Teaching language skills., in The practice of English language teaching2007, Pearson Education: Essex, England. p. 265-282.20. Mayora, C.A., Extensive listening in a Colombian university: Process, product, and perceptions. HOW, 2017. 24(1): p. 101-121.21. Cohen, L., L. Manion, and K. Morrison, Tests., in Research methods in education2011, Routledge: Oxon, England. p. 476-495.22. Richards, J.C., Listening Comprehension: Approach, Design, Procedure. TESOL quarterly, 1983. 17(2): p. 219-240.23. Foddy, W. and W.H. Foddy, Constructing questions for interviews and questionnaires: Theory and practice in social research1994: Cambridge university press.24. Kiany, G.R. and E. Shiramiry, The effect of frequent dictation on the listening comprehension ability of elementary EFL learners. TESL Canada Journal, 2002. 20(1): p. 57-63.25. Harding, K. and P. Henderson, High Season2000, Oxford, England: Oxford University Press.26. Walker, R. and K. Harding, in Tourism 12006, Oxford University Press: Oxford, England. p. 93.

Abstract Purpose This study presents a series of paediatric meningiomas and discusses aetiology, risk factors and outcomes with comparison to current literature. Methods This is a retrospective review of surgically treated paediatric meningiomas from three UK centres: the University Hospital of Wales, Alder Hey Children’s Hospital and Royal Manchester Children’s Hospital. Twenty-seven patients aged 16 and under at the time of their first procedure were identified over a 15-year period (1 January 2007 and 1 March 2023). Electronic medical records were used to collect data on age at presentation, sex, location of tumour(s), extent of resection, histology, WHO grade, complications, outcomes and associated conditions, notably neurofibromatosis type 2 (NF2). Results Twenty-seven patients underwent 39 procedures. There were 13 males and 14 females. The median age was 13 years (range, 8 months to 16 years). Twenty-one (75%) were WHO grade 1, 6 (21%) were grade 2 and 1 (4%) was grade 3. Eight patients (30%) had confirmed NF2. Twelve patients (44%) were sporadic cases. Twenty-five percent and 50% were the recurrence rate in WHO grade 1 and 2 tumours, respectively. Conclusion The risk of grade 1 tumour recurrence was higher than within the adult population. This may be due to histological features of paediatric meningiomas differing from the adult population, and therefore, the WHO grading system may not be reflective of recurrence risk. Future molecular profiling and larger studies are required given the rarity of these cases.

Zusammenfassung Hintergrund Diese Studie ist eine Analyse der Fluoreszeinangiographie (FAG) und der Indocyaningrünangiographie (ICGA) im universitätsmedizinischen Setting, deren primäres Ziel die Analyse der unerwünschten Arzneimittelwirkungen (UAW) und deren Schweregrad (mild, moderat, schwer) ist. Sekundäres Ziel der Studie ist es, die Indikationsstellung von FAG und ICGA vor und während der COVID-19-Pandemie zu untersuchen. Methodik Eine retrospektive Analyse aller FAG und ICGA an der Universitätsaugenklinik in Würzburg im Zeitraum von Januar 2016 bis Ende Dezember 2021 wurde durchgeführt. Dabei wurden UAW, Geschlecht, Alter, Untersuchungszeitpunkte und Indikation ausgewertet. Die Einteilung der UAW erfolgte in mild, moderat und schwer, angelehnt an die Definition von Kornblau et al. [1]. Ergebnisse Insgesamt wurden 4900 Datensätze von 4193 Patienten ausgewertet. Die FAG wurde etwas häufiger bei Männern (54,8 %) als bei Frauen (45,2 %) durchgeführt, und das Durchschnittsalter betrug 63,2 ± 16,9 Jahre (Median: 65 Jahre). UAW traten nur bei 1,65 % aller FAG auf, hiervon waren 1,27 % milde und 0,39 % moderate UAW. Es traten keine schweren UAW auf. Die häufigste UAW war mit 59,26 % eine Nausea. Bei der ICGA traten keine UAW auf. Die jährliche Anzahl der FAG betrug durchschnittlich 816,7 ± 91,1 und war im gesamten Zeitraum bis auf eine signifikant reduzierte Anzahl im Jahr 2016 (im Vergleich zu 2018, 2019 und 2021) relativ konstant. Die häufigste Indikation zur FAG waren venöse retinale Verschlüsse mit 22,93 % (N = 774), hierbei zeigte sich 2021 eine signifikante Zunahme im Vergleich zu den Jahren 2018 bis 2020. Eine ICGA wurde in 4,18 % der Fälle durchgeführt, wobei die häufigste Indikation eine Uveitis mit 31,82 % (N = 63) war. Diskussion Im Vergleich zu anderen Studien kam es zu sehr wenigen UAW, und in keinem Fall kam es zu einer lebensbedrohlichen UAW. Venöse retinale Verschlüsse waren sehr häufig die Indikation zur FAG, wahrscheinlich aufgrund der oft notwendigen Wiederholung der Untersuchung bei diesem Krankheitsbild. Kurzzeitig während des ersten Lockdowns (18.03. bis 08.05.2020) konnte eine Abnahme der Angiographien beobachtet werden, aber über einen längeren Zeitraum zeigten sich keine signifikanten Unterschiede im Vergleich zu der Zeit vor der Pandemie.

<strong>Mędrak Anna,</strong><strong> Rżany Michał,</strong><strong> Otremba Barbara, Brodowska Elwira, Szynal Magdalena, Alcer Magdalena, Górecka Anna, Stefaniak Tomasz,</strong><strong> Suszyński Krzysztof, Górka Dariusz. </strong><strong>Akademickie Związki Sportowe jako droga do rozwoju aktywności sportowej wśród studentów śląskich uczelni = </strong><strong>University Sports Association as the way to sport activity development among Silesian students. </strong><strong>Journal of Education, Health and Sport. </strong><strong>2015;5(11):616-628. eISSN 2391-8306. DOI</strong> <strong>http://dx.doi.org/10.5281/zenodo.35711</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2811%29%3A616-628</strong> <strong>http://pbn.nauka.gov.pl/works/684931</strong> <strong>Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014</strong> <strong>http://journal.rsw.edu.pl/index.php/JHS/issue/archive</strong> <strong>Original Text published © </strong><strong>The Author (s) 2015. </strong><strong>Mędrak Anna,</strong><strong> Rżany Michał,</strong><strong> Otremba Barbara, Brodowska Elwira, Szynal Magdalena, Alcer Magdalena, Górecka Anna, Stefaniak Tomasz,</strong><strong> Suszyński Krzysztof, Górka Dariusz. </strong><strong>Akademickie Związki Sportowe jako droga do rozwoju aktywności sportowej wśród studentów śląskich uczelni</strong><strong>. </strong><strong>Quality in Sport. 2015;1</strong><strong>(3):38-49. </strong><strong>eISSN 2450-3118.</strong> <strong>The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).</strong> <strong>755 Journal of Education, Health and Sport (null) 2391-8306 7</strong> <strong>© The Author (s) 2015;</strong> <strong>This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland.</strong> <strong>Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,</strong> <strong>provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License</strong> <strong>(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial</strong> <strong>use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>The authors declare that there is no conflict of interests regarding the publication of this paper.</strong> <strong>Received: 15.11.2015. Revised 20.11.2015. Accepted: 30.11.2015.</strong> <strong>Anna Mędrak,</strong><strong> Michał Rżany,</strong><strong> Barbara Otremba, Elwira Brodowska, Magdalena Szynal, Magdalena Alcer, Anna Górecka, Tomasz Stefaniak,</strong><strong> Krzysztof Suszyński, Dariusz Górka</strong> Zakład Medycyny Sportowej i Fizjologii Wysiłku Fizycznego, Katedra Fizjoterapii, Wydział Nauk o Zdrowiu, Śląski Uniwersytet Medyczny w Katowicach <strong>Akademickie Związki Sportowe jako droga do rozwoju aktywności sportowej wśród studentów śląskich uczelni</strong> <strong>University Sports Association as the way to sport activity development among Silesian students</strong> <strong>Streszczenie</strong> <strong>Wstęp. </strong>Regularna aktywność fizyczna i prawidłowe odżywianie to dwa fundamentalne filary filozofii zdrowego stylu życia. Rozwój aktywności fizycznej wśród studentów uwarunkowany jest wieloma złożonymi czynnikami, wśród których wyróżniamy: profil studiów, dostęp do infrastruktury sportowej oraz możliwość brania udziału w zajęciach sportowych organizowanych przez kluby czy Akademickie Związki Sportowe. <strong>Cel pracy. </strong>Celem pracy była analiza czynników mających wpływ na samoocenę aktywności fizycznej studentów. Postawiono następujące pytania badawcze: Czy wybór uczelni ma związek z dostępem do zajęć organizowanych przez Akademickie Związki Sportowe? Czy branie udziału w zajęciach organizowanych przez AZS ułatwia rozwój sportowy? Czy istnieje zależność pomiędzy lokalizacją miejsc, w których organizowane są zajęcia sportowe, godzinami odbywania się zajęć sportowych, rodzajem i formą zajęć sportowych a korzystaniem z oferty AZS? <strong>Materiały i metody. </strong>W badaniach wzięło udział 395 studentów, w tym 257 kobiet w wieku od 18 do 27 lat (x=20,7; SD=1,4) i 108 mężczyzn w wieku od 18 do 26 lat (x=21; SD=1,45). Wśród badanych znaleźli się studenci z pięciu śląskich uczelni wyższych. Metodą zastosowaną w trakcie badania była anonimowa ankieta składająca się z 37 zamkniętych pytań, które dotyczyły następujących kwestii: formy podejmowanej aktywności fizycznej, Akademickich Związków Sportowych oraz wpływu obranego kierunku studiów na rozwój aktywności fizycznej. W 21 pytaniach w ankiecie posłużono się skalą Likerta. Opracowanie statystyczne obejmowało wykonanie statystyk opisowych, natomiast poziom różnic określono za pomocą analizy wariancji ANOVA. <strong>Wyniki. </strong>Analiza statystyczna wykazała istotną zależność pomiędzy rodzajem uczelni a lokalizacją miejsc w których odbywają się zajęcia organizowane przez AZS (p=0,04). Rodzaj uczelni natomiast nie wpływa na czynniki takie jak: godziny w których odbywają się zajęcia sportowe (p=0,07) oraz rodzaj zajęć sportowych znajdujących się w ofercie (p=0,39). Istnieje istotna zależność miedzy rodzajem uczelni a rezygnacją z uprawiania sportu (p=0,0002). Najczęściej muszą z niego rezygnować studenci Śląskiego Uniwersytetu Medycznego, a najrzadziej Uniwersytetu Śląskiego. Istnieje również zależność między podejściem do uprawiania sportu a rodzajem uczelni (p=0,01). Najbardziej ułatwia karierę sportową Uniwersytet Ekonomiczny w Katowicach. <strong>Wnioski:</strong> Podejmowanie aktywności fizycznej przez studentów jest zależne od lokalizacji uczelni oraz miejsc, w których odbywają się zajęcia. Czynniki takie jak godziny odbywania się zajęć, oraz rodzaj zajęć nie są zależne od rodzaju uczelni. Rodzaj uczelni ma wpływ na rezygnację z uprawnia sportu. <strong>Słowa kluczowe:</strong> aktywność fizyczna, Akademickie Związki Sportowe. <strong>Abstract</strong> <strong>Introduction. </strong>There are two fundaments of healthy lifestyle philosophy: regular physical activity and proper diet. The development of physical activity among students is determined by many complex factors. We can distinguish certain aspects such as university profile, access to the sport facilities and the opportunity to participate in sport activities which are organized by sport clubs or University Sports Association. <strong>The aim of the study. </strong>The aim of the study was to analyze the factors that affect self-assessment of students physical activity. The following questions have been asked: 1.Is the choice of the university related to the access to sport activities which are organized by University Sport Association? 2.Does the participating in activities, which are organized by University Sport Association, help in physical development? 3.Is there any relation between the location, time, type, the way of sport activities which are offered by University Sport Association and participating in them? <strong>Material and methods. </strong>395 students took part in research: 257 women (18-27 years old) (x=20,7 ; SD=1,4) and 108 men (18-26 years old) (x=21; SD=1,45). All the students are from five Silesian universities. Method used for the research was the anonymous questionnaire consisting of 37 questions which concerned: the way of the physical activity taken by students, the issue of University Sport Association and the influence of the university profile on physical activity development. The Likert scale was used in 21 questions. Statistical description included descriptive statistics. Degree of difference was defined by ANOVA analysis. <strong>Results. </strong>Descriptive analysis showed significant dependence between the type of the university and the location of sport facilities (p=0,04). The type of the university has no influence on the factors like: time (p=0,07) and type of sport activities offered by University Sport Association (p=0,39). There is also an important connection between the type of the university and resignation from doing sport (p=0,0002). Mostly – Medical University of Silesia students, least frequently – University of Silesia students. There is dependence between approach to doing sport among students and the type of university (p=0,01). The university which helps the most in sport career is University of Economics in Katowice. <strong>Conclusions:</strong> 1.Taking the physical activity by student depends on location of the university and sport facilities. 2.The factors such as time and type of sport activities are not related to the type of the university. 3.The type of the university influence the resignation from doing sport by students. <strong>Key words:</strong> physical activity, University Sports Association.

We are pleased to present the International Journal of Digital Law to the professional and academic community. We seek to create a new scientific journal, with the intention of filling a gap that still exists in dealing with the topic, both at the local and global levels. The International Journal of Digital Law consists of an open-access electronic scientific journal and published every four months by NUPED &ndash; Center for Research in Public Policies and Human Development of the Postgraduate Law Program at the Pontifical Catholic University of Paran&aacute; &ndash; an affiliated research group to REDAS &ndash; Research Network in Welfare State Administrative Law. The Editorial Board is composed of renowned professors linked to higher education institutions in Brazil, Argentina, Australia, Colombia, Spain, Egypt, France, and India. The journal&rsquo;s focus is the critical study of the legal-political institutions typical of the rule of law, notably those aimed at innovation and human development through the digital revolution. We are grateful for the frank availability of the professors who agreed to compose both the Editorial Board and the Special Peer Review Bord. NUPED is part of the PPGD/PUCPR Concentration area entitled &ldquo;Economic Law and Development&rdquo;. In turn, the area brings together two important lines of research: 1. State, Economy and Development and 2. Social Rights, Globalization and Development. The magazine will highlight this theoretical framework. However, transversely to the theme of economics, development, globalization and social rights, the keywords that best define the scope of the magazine involve dealing with topics such as access to information, Big data, Blockchain, Smart Cities, Smart contracts, Crowdsourcing, Cybercrimes, Digital democracy, Right to privacy, Fundamental rights, E-business, Digital economy, Digital education, Administrative efficiency, E-Government, Fake News, Gig economy, Globalization, Digital inclusion, Infrastructure, Innovation, Artificial intelligence, Public interest, Internet, Internet of things, Jurimetrics, Lawfare, New technologies, Digital profiling, Multimedia research, Electronic administrative process, Data protection, Administrative regulation, Economic regulation, Risk, Public services, Information systems, Information society, Government transparency, and Telecommunications. And the journal&rsquo;s scope is, therefore, strongly interdisciplinary and transdisciplinary. It is expected that scholars from the most different fields of research will be able to send their works, which will be very well received and can be written in Portuguese, English or Spanish. In this first issue, in addition to articles by&nbsp;Brazilian researchers, we have texts from three different countries and continents: Argentina, Spain and India. All articles will go through the evaluation system in double-blind peer review. The idea is that the International Journal of Digital Law will quickly become a reference in terms of academic seriousness and impact on society. For that, we will try to fit in the guidelines of the most important national and international indexing bases. Emerson Gabardo, Alexandre Godoy Dotta, Juan Gustavo Corval&aacute;n &nbsp; &nbsp; Artigos Inteligencia Artificial GPT-3, Pretoria y Or&aacute;culos Algor&iacute;tmicos en el DerechoGPT-3 Artificial Intelligence, Pretoria, and Algorithmic Oracles in Law Juan Gustavo Corval&aacute;n p.11-52 &nbsp;PDF (Espa&ntilde;ol (Espa&ntilde;a)) Cybercrime Regulation through Laws and Strategies: A Glimpse into the Indian ExperienceRegulamenta&ccedil;&atilde;o do crime cibern&eacute;tico por meio de leis e estrat&eacute;gias: um vislumbre da experi&ecirc;ncia Indiana Annappa Nagarathna p.53-64 &nbsp;PDF (English) Marco Europeo para una inteligencia artificial basada en las personasEuropean framework for people-based artificial intelligence &Aacute;lvaro Avelino S&aacute;nchez Bravo p.65-77 &nbsp;PDF (Espa&ntilde;ol (Espa&ntilde;a)) Intelig&ecirc;ncia artificial: machine learning na Administra&ccedil;&atilde;o P&uacute;blicaArtificial intelligence: machine learning in public administration Carla Regina Bortolaz de Figueiredo, Fl&aacute;vio Garcia Cabral p.79-96 &nbsp;PDF Inclus&atilde;o digital e blockchain como instrumentos para o desenvolvimento econ&ocirc;micoDigital inclusion and blockchain as instruments for economic development Denise Bittencourt Friedrich, Juliana Horn Machado Philippi p.97-116 &nbsp;PDF Asistencia virtual automatizada e inclusiva para optimizar la relaci&oacute;n de la ciudadan&iacute;a con la Administraci&oacute;n P&uacute;blicaAutomated and inclusive virtual assistance to optimize the relationship of citizens with the Public Administration Antonella Stringhini p.117-128 &nbsp;PDF (Espa&ntilde;ol (Espa&ntilde;a)) &nbsp;

INTRODUCTIONStudies using filters for the separation of non‐bound 25‐OH‐vitamin D (25HD), and measurements by commercial ELISA kits, suggest the existence of a physiologically important unbound fraction. Accurate measurement of weakly‐bound, highly hydrophobic ligands in aqueous environment is a major challenge. We sought to confirm earlier reports suggesting that an unbound fraction of 25HD in normal plasma can be measured by standard chemical procedures.MATERIAL &amp; METHODSNormal human plasma was centrifuged through various filters with nominal 30K pore sizes; the presence of 25HD in the filtrate was determined by using a Diels‐Alder derivatization reagent (Amplifex, from AB‐Sciex) followed by analysis on LC/MS‐MS, with a lower detection limit of approximately 0.5 pg. In parallel experiments, we also sought to determine the limit of aqueous solubility of 25HD in distilled water and in blood bank saline (BBS).RESULTSWhen 1 ml of plasma with 25HD over the range of 20–40 ng/ml was centrifuged with CentriFree 30K MWCO filters, there were no detectable analytes in the filtrate. This could be interpreted as the total amount of 25HD that could pass through the filter is less than 0.5 pg/ml, in contrast to the previously reported 10–20 pg/mL. When 25HD stock material (dissolved in ethanol) was diluted 1/10,000 with distilled water or BBS, the detectable amount of 25HD in multiple aliquots were highly variable (10% CV), and well below anticipated quantity of a true homogenous solution (30%). Increasing the ethanol concentration to 1% resulted in a solution whose properties approached classical solubility behavior, but this strategy for dissolving 25HD cannot be taken as demonstrating physiological validity.DISCUSSIONThe inability for 25HD to form a true homogenous solution in aqueous environments severely hinders studies of protein binding. This data suggests that the amount of 25HD from plasma that can pass through 30k MWCO filters is below 0.5 pg/mL, which is a much smaller fraction of unbound 25HD than previously reported using filtration studies. Furthermore, this study also suggests that the behavior of highly hydrophobic compounds, such as 25HD, cannot be modeled under the free hormone hypothesis; the behavior of population of 25HD that are not tightly bound to vitamin D binding protein (VDBP) may require different models of protein‐protein interactions.Support or Funding InformationSupported by a graduate fellowship from University of Massachusetts Lowell to Yuguan Liu

Mit der Ratifizierung der UN-Behindertenrechtskonvention 2009 verpflichtete sich Deutschland, Anforderungen an und Aufgaben in der Lehramtsausbildung in Hinblick auf die Gestaltung eines inklusiven Schulsystems hin zu überprüfen und zu adaptieren. Dies trifft in Deutschland auf ein dreigliedriges Schulsystem, welches auf dem Leistungsprinzip und einem engen, dichotomen Behinderungsverständnis fußt. Dementsprechend wird zwischen verschiedenen pädagogischen Professionen, z. B. Regelschullehrer*innen und Sonderpädagog*innen, differenziert und nach unterschiedlichen Anforderungsprofilen ausgebildet. Einem weiten Inklusionsverständnisses folgend konstituieren sich jedoch diverse Anforderungen an alle pädagogisch Handelnden, welches wiederum das Professionsverständnis, die Aufgaben und Anforderungen in der allgemeinen Lehramtsausbildung bestimmt. Dem folgend befasst sich der Beitrag für die Vermittlung von multiprofessionellen Kompetenzen in der allgemeinen Lehramtsausbildung mit dem Ziel, Lehrpersonen vor dem Hintergrund eines weiten Inklusionsverständnisses auf die Schulpraxis vorzubereiten. Der Beitrag orientiert sich an folgenden Fragen: Welche Kompetenzbereiche konstituieren eine inklusionsorientierte Professionalisierung von Studierenden des allgemeinen Lehramts in Niedersachsen? Inwiefern werden die identifizierten multiprofessionellen Kompetenzen während der Qualifizierung von Studierenden des allgemeinen Lehramts formal berücksichtigt? Zur Bearbeitung dieser Fragestellungen werden anhand einer Dokumentenanalyse relevante Hochschuldokumente aller Regellehramtsstudiengänge in Niedersachsen analysiert. Die Auswertung orientiert sich an der qualitativen Inhaltsanalyse nach Mayring (2023). Als theoretische Grundlage dient das heuristische Mehrebenenmodell von Heimlich (2003), um darzustellen, dass der multiprofessionelle Kompetenzerwerb interdependent und reziprok über die einzelnen Ebenen verläuft. Der Beitrag zeigt auf, dass sich der multiprofessionelle Kompetenzerwerb von Studierenden anhand der drei Schlüsselkompetenzen von (1) Diversitätssensibilität, (2) pädagogischer Diagnostik und (3) Sprachförderung konstituiert, diese aber sehr unterschiedlich verankert und implementiert sind. Abstract With the ratification of the UN Convention on the Rights of Persons with Disabilities in 2009, Germany committed itself to reviewing and adapting the requirements and tasks in teacher training with regard to the design of an inclusive school system. In Germany, this involves a three-track school system based on performance and a narrow understanding of disability. Accordingly, a distinction is made between pedagogical professions, e.g. regular schoolteachers and special needs teachers, and they are trained according to different requirement profiles. Following a broad understanding of inclusion, however, various requirements are placed on all educational practitioners, which in turn determines the understanding of the profession, the tasks and requirements in general teacher training. In line with this, the article deals with for the teaching of multi-professional competences in general teacher training with the aim of preparing teachers for inclusive school practice against the background of a broad understanding of inclusion. The article addresses the following questions: Which areas of competence constitute an inclusion-oriented professionalization of general teacher training students in Lower Saxony? To what extent are the identified multi-professional competences formally taken into account during the qualification of general teacher training students? To address these questions, relevant university documents from all standard teaching degree courses in Lower Saxony are analyzed based on a document analysis. The evaluation is based on the qualitative content analysis according to Mayring (2023). Heimlich’s (2003) heuristic multi-level model serves as a theoretical basis to show that the multi-professional acquisition of skills is interdependent and reciprocal across the individual levels. The article shows that the multi-professional acquisition of skills by students is based on the three key skills of (1) diversity sensitivity, (2) special educational diagnostics and (3) language support, which are, however, anchored and implemented very differently.