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Journal articles on the topic 'University of Colorado at Denver and Health Sciences Center'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Fagan, Karen A., David B. Badesch, C. Gregory Elliott, and Robert P. Frantz. "• Recapping Highlights from the 2006 PHA Scientific Sessions• Reviewing New Perspectives on Inflammation, Genetics, and Imaging• Redefining Exercise-Induced PH• Future Considerations in Translational Research." Advances in Pulmonary Hypertension 5, no. 3 (2006): 34–39. http://dx.doi.org/10.21693/1933-088x-5.3.34.

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This discussion was moderated by Karen A. Fagan, MD, Associate Professor of Medicine, University of Colorado Health Sciences Center, Denver, Colorado. Panel members included David B. Badesch, MD, Professor of Medicine, Divisions of Pulmonary Sciences & Critical Care Medicine, and Cardiology Clinical Director, Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, Colorado; C. Gregory Elliott, MD, Professor of Medicine, University of Utah School of Medicine, Pulmonary Division, LDS Hospital, Salt Lake City, Utah; and Robert P. Frantz, MD, Assistant Professor of Medicine, Mayo Clinic College of Medicine, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.

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Rosenzweig, Erika Berman, Steven H. Abman, Dunbar Ivy, and Sheila G. Haworth. "• Identifying the Complex Spectrum of Childhood PAH• Selecting Candidates for Aggressive Treatment." Advances in Pulmonary Hypertension 5, no. 2 (2006): 36–42. http://dx.doi.org/10.21693/1933-088x-5.2.36.

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This discussion was moderated by Erika Berman Rosenzweig, MD, Assistant Professor of Pediatrics (in Medicine), Columbia University College of Physicians and Surgeons, New York, New York. Panel members included Steven H. Abman, MD, Professor of Pediatrics and Director of the Pediatric Heart-Lung Center at The Children’s Hospital, University of Colorado School of Medicine, Denver, Colorado; Dunbar Ivy, MD, Associate Professor of Pediatrics, University of Colorado Health Sciences Center, The Children’s Hospital, Chief of Pediatric Cardiology, and Director of the Pulmonary Hypertension Program, University of Colorado Health Sciences Center, Denver, Colorado; and Sheila G. Haworth, MD, FRCP, Professor of Developmental Cardiology, Institute of Child Health, University College, London, UK, and Lead Clinician at the United Kingdom Pulmonary Hypertension Service for Children.

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3

Seaman, Scott. "Collaborative Collection Management in a High-density Storage Facility." College & Research Libraries 66, no. 1 (2005): 20–27. http://dx.doi.org/10.5860/crl.66.1.20.

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This case study reviews selected collection management issues encountered in a collaboratively managed high-density remote storage facility. In 2000, four Colorado institutions—the University of Colorado at Boulder, the University of Colorado at Denver, the University of Colorado Health Sciences Center, and the University of Denver—opened a shared high-density storage facility. This mix of public and private institutions agreed to collaborative collection management, including a nonduplication policy and the granting of direct access to stored materials for nonparticipating institutions through a statewide union catalog. Ownership of stored materials, selection of items for storage, operational management, and online and physical access proved to be challenging policy issues requiring committees, patience, and compromise to resolve.

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McLaughlin, Vallerie, James R. Seibold, David B. Badesch, and Virginia Steen. "Screening for PAH in Scleroderma: Identifying Hallmarks of the Disease and Optimal Treatment Strategies." Advances in Pulmonary Hypertension 1, no. 2 (2002): bmi—25. http://dx.doi.org/10.21693/1933-088x-1.2.bmi.

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Vallerie McLaughlin, MD, Associate Professor of Medicine, Rush Presbyterian-St. Luke's Medical Center, Chicago, Illinois, conducted this roundtable discussion. The panel included James R. Seibold, MD, Professor and Director, UMDNJ Scleroderma Program. New Brunswick New Jersey; David B. Badesch, MD, Professor of Medicine and Clinical Director, Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, Colorado; and Virginia Steen, MD, Professor of Medicine, Georgetown University Medical Center, Washington, DC.

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Neubauer, Jane. "Leader Interview: Self-Development and the Arts." Creative Nursing 6, no. 4 (2000): 5–14. http://dx.doi.org/10.1891/1078-4535.6.4.5.

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This Leader Interview is with Jane Neubauer, RN, MS. She does personal and organizational development through her consulting business, The Creative Leadership Retreat. She did similar work with the British National Health Service at the King’s Fund, a foundation in London. She had been an executive and educator at the University of Wyoming, University of Colorado Health Sciences Center, Mercy Medical Center, Denver, and University of Cincinnati Health Sciences Center. Carol Lindeman, RN, PhD, FAAN, conducted the interview.

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Gaine, Sean, Nicholas W. Morrell, Stuart Rich, and Norbert Voelkel. "Future Directions: An Expert Panel Explores the Challenge of Halting Progression and Reversing the Pathology of PAH." Advances in Pulmonary Hypertension 2, no. 4 (2003): 22–27. http://dx.doi.org/10.21693/1933-088x-2.4.22.

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This discussion was moderated by Sean Gaine, MD, Director, Pulmonary Hypertension Unit, Mater Misericordiae Hospital, University College, Dublin, Ireland. The physicians participating included Stuart Rich, MD, Professor of Medicine, and Director, Rush Heart Institute Center for Pulmonary Heart Disease, Rush Presbyterian-St. Luke's Medical Center, Chicago, Illinois, Norbert Voelkel, MD, The Hart Family Professor of Emphysema Research, University of Colorado Health Sciences Center, Denver, Colorado, and Nicholas W. Morrell, MD, Director, Pulmonary Vascular Diseases Unit, Papworth and Addenbrooke's Hospitals, University of Cambridge School of Clinical Medicine, Cambridge, UK.

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7

Krygowski, Monica, and Helen Thompson. "Report from the University of Colorado at Denver and Health Sciences Center: Translational Collaborative Efforts." Obesity Management 3, no. 5 (2007): 222–23. http://dx.doi.org/10.1089/obe.2007.0067.

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8

Halpern, Scott, David B. Badesch, Michael D. McGoon, and Myung Park. "Ethical Considerations for RCTs in PAH." Advances in Pulmonary Hypertension 8, no. 1 (2009): 42–46. http://dx.doi.org/10.21693/1933-088x-8.1.42.

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A roundtable discussion on ethical issues relating to the conduct of randomized clinical trials (RCTs) with pulmonary arterial hypertension (PAH) patients was held during the May 2009 American Thoracic Society meeting in San Diego. Scott Halpern, MD, PhD, MBE, Assistant Professor of Medicine and Epidemiology, Pulmonary, Allergy, and Critical Care Division, and Senior Fellow in the Center for Bioethics at the University of Pennsylvania, Philadelphia, facilitated the discussion among participants Myung H. Park, MD, Director, Pulmonary Vascular Diseases Program, University of Maryland School of Medicine, Baltimore, Maryland; David B. Badesch, MD, Professor of Medicine, Divisions of Pulmonary Sciences and Critical Care Medicine, and Cardiology, and Clinical Director of the Pulmonary Hypertension Center, University of Colorado at Denver Health Sciences Center; and Michael D. McGoon, MD, Professor of Medicine, Department of Cardiology, Pulmonary Hypertension Clinic, Mayo Clinic, Rochester, Minnesota.

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9

Hill, James O. "The Expert Weighs In Pediatric Obesity Interview with Stephen R. Daniels, M.D., Chair, Department of Pediatrics University of Colorado at Denver and Health Sciences Center." Obesity Management 2, no. 6 (2006): 218–22. http://dx.doi.org/10.1089/obe.2006.2.218.

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10

Mirtallo, Jay M. "Clinical Assessment of Extracellular Fluid Volume in Hyponatremia H. CHUNG, R. KLUGE, R. SCHRIER, AND R. AN-DERSON Department of Medicine, Veterans Administration Medical Center, and Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado." Nutrition in Clinical Practice 3, no. 5 (1988): 206–7. http://dx.doi.org/10.1177/088453368800300510.

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11

Samuels, Mary H., Charlotte F. Sanborn, Frederick Hofeldt, and Richard Robbins. "The role of endogenous opiates in athletic amenorrhea**Supported in part by Adult General Clinical Research Center grant MO1 RR00051 University of Colorado Health Science Center, Denver, Colorado, and National Institutes of Health grant DK 36843-03 Bethesda, Maryland." Fertility and Sterility 55, no. 3 (1991): 507–12. http://dx.doi.org/10.1016/s0015-0282(16)54176-4.

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12

Afdhal, Nezam H., Douglas T. Dieterich, Paul J. Pockros, et al. "Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study1 1The other PROACTIVE Study Group investigators included the following: Vijayan Balan, M.D., Mayo Clinic Scottsdale, Scottsdale, Arizona; Norbert Bräu, M.D., Bronx VA Medical Center, Bronx, New York; Robert Brown, M.D., M.P.H., NY Presbyterian Medical Center, New York, New York; William Carey, M.D., Cleveland Clinic Foundation, Cleveland, Ohio; Andrea Duchini, M.D., Baylor College of Medicine, Houston, Texas; Greg Everson, M.D., University of Colorado Health Sciences Center, Denver, Colorado; Michael Fried, M.D., University of North Carolina, Chapel Hill, North Carolina; Robert Gish, M.D., California Pacific Medical Center, San Francisco, California; Ira Jacobson, M.D., Weill Medical College of Cornell University, New York, New York; John W. King, LSU Health Sciences Center, Shreveport, LA; Raymond Koff, M.D., University of Massachusetts Memorial Health Care, Worcester, Massachusetts; William Lee, M.D., University of Texas Southwestern Medical Center, Dallas, Texas; Mark A. Levstik, M.D., The University of Tennessee, Memphis, Tennessee; John G. McHutchison, M.D., Scripps Clinic, La Jolla, California; Marion Peters, M.D., University of California San Francisco, San Francisco, California; Kenneth Sherman, M.D., Ph.D., University of Cincinnati College of Medicine, Cincinnati, Ohio; Coleman Smith, M.D., Minnesota Clinical Research Center, St. Paul, MN; Ronald Wasserman, M.D., Hepatitis Resource Center, Walnut Creek, California." Gastroenterology 126, no. 5 (2004): 1302–11. http://dx.doi.org/10.1053/j.gastro.2004.01.027.

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13

Slover, Robin. "Transdermal fentanyl: Clinical trial at the University of Colorado Health Sciences Center." Journal of Pain and Symptom Management 7, no. 3 (1992): S45—S47. http://dx.doi.org/10.1016/0885-3924(92)90053-k.

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14

Chadaga, Smitha R., Angela Keniston, Dan Casey, and Richard K. Albert. "Correlation Between Self-Reported Resident Duty Hours and Time-Stamped Parking Data." Journal of Graduate Medical Education 4, no. 2 (2012): 254–56. http://dx.doi.org/10.4300/jgme-d-11-00142.1.

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Abstract Background Failure to comply with Accreditation Council for Graduate Medical Education-mandated resident work hour limitations can result in citations and shortened accreditation cycles. Many programs assess compliance by collecting self-reports of work hours from each resident. Objectives To examine residents' self-reported assessment of work hours recorded on a daily basis using a Web-based product with electronically recorded times collected as residents entered and exited the parking garage. Methods Study participants consisted of 62 University of Colorado Denver internal medicine residents rotating at Denver Health Medical Center on a monthly basis over a 4-month period. Self-reported data submitted by 60 residents were compared with the times these residents entered and exited from the parking garage at Denver Health Medical Center, as assessed by an electronic badge reader. Results A high level of agreement was found between these two data sets. No significant difference was found between the time-stamped parking data and self-reported Web-based data for resident work hours. Conclusions Residents accurately self-reported their work hours, using a daily Web-based duty hours log when compared to an independent, objective and blinded assessment of work hours.

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15

Forsman, Rick B. "The Evolution and Application of Assessment Strategies at the University of Colorado Health Sciences Center." Journal of Library Administration 40, no. 3-4 (2004): 73–82. http://dx.doi.org/10.1300/j111v40n03_06.

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16

McPoil, Thomas G. "Is Excellence in the Cards?" Physical Therapy 99, no. 10 (2019): 1281–90. http://dx.doi.org/10.1093/ptj/pzz104.

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ABSTRACT Thomas G. McPoil, PT, PhD, FAPTA, is Emeritus Professor of Physical Therapy at Regis University, Denver, Colorado, and Emeritus Regents’ Professor of Physical Therapy at Northern Arizona University. He has served as an Adjunct Honorary Professor in the School of Physiotherapy at the University of Queensland, Brisbane, Australia, and currently serves as a consultant to the Physical Therapy Orthotics Clinic at Denver Health Medical Center, Denver, Colorado. Dr. McPoil is known nationally and internationally for his scholarly contributions that have systematically examined foot and ankle function from both scientific and clinical perspectives. Dr. McPoil is an author or coauthor of 130 publications in peer-reviewed journals, coeditor of 2 books, and coauthor of 6 book chapters. His work reaches beyond the profession of physical therapy, as he served on the editorial boards of Foot and Ankle International, the Journal of Foot and Ankle Research, and Research in Sports Medicine and is currently on the editorial boards of the Journal of the American Podiatric Medical Association and The FOOT. Dr McPoil received his PhD in kinesiology with a specialization in biomechanics from University of Illinois at Urbana–Champaign. He holds an MS in physical education with a specialization in athletic training from Louisiana State University and a BA in physical education from the California State University, Sacramento. During his career, he has held faculty appointments at the University of Illinois at Chicago, Northern Arizona University, and Regis University. Dr McPoil’s clinical practice has focused on the management of chronic orthopedic foot and ankle disorders for the past 38 years. Dr McPoil is the founding president of the Foot and Ankle Special Interest Group of the Academy of Orthopaedic Physical Therapy. He has served as Vice President of the Academy of Orthopaedic Physical Therapy and as the Treasurer of the Journal of Orthopaedic and Sports Physical Therapy. He has received numerous teaching awards, including APTA’s Dorothy E. Baethke & Eleanor J. Carlin Award for Excellence in Academic Teaching and the Academy of Orthopaedic Physical Therapy’s James A. Gould Excellence in Teaching Orthopaedic Physical Therapy Award. He is a recipient of a Fulbright Senior Scholar Award, the William J. Stickel Award for Research in Podiatric Medicine, the Academy of Orthopaedic Physical Therapy’s Stanley Paris Distinguished Service Award and was elected a Catherine Worthingham Fellow of APTA in 2007.

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Fagan, Karen, Todd Bull, Ivan F. McMurtry, and Omar A. Minai. "PHA Scientific Sessions Provide a Great Window Into Treatment Breakthroughs While Inspiring Physicians and Patients Alike." Advances in Pulmonary Hypertension 7, no. 3 (2008): 353–55. http://dx.doi.org/10.21693/1933-088x-7.3.353.

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This roundtable discussion, reviewing the proceedings from the Pulmonary Hypertension Association's Eighth International PH Conference and Scientific Sessions in Houston in 2008, was moderated by Karen Fagan, MD, Chief, Division of Pulmonary and Critical Care Medicine, University of South Alabama, Mobile, Alabama. It included Todd Bull, MD, Associate Professor of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Aurora, Colorado; Ivan F. McMurtry, PhD, Professor, Department of Pharmacology, University of South Alabama School of Medicine, Mobile, Alabama; and Omar A. Minai, MD, Staff Physician in the Department of Pulmonary, Allergy, and Critical Care Medicine and the Lung Transplant Center at the Cleveland Clinic, Cleveland, Ohio.

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18

Clark, Peter A. "Placebo Surgery for Parkinson's Disease: Do the Benefits Outweigh the Risks?" Journal of Law, Medicine & Ethics 30, no. 1 (2002): 58–68. http://dx.doi.org/10.1111/j.1748-720x.2002.tb00720.x.

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In April 1999, Dr. Curt Freed of the University of Colorado in Denver and Dr. Stanley Fahn of Columbia Presbyterian Center in New York presented the results of a four-year, $5.7 million government-financed study using tissue from aborted fetuses to treat Parkinson’s disease at a conference of the American Academy of Neurology. The results of the first government-financed, placebo-controlled clinical study using fetal tissue showed that the symptoms of some Parkinson’s patients had been relieved. This research study involved forty subjects, nineteen women and twenty-one men; all suffered from Parkinson’s disease for an average of 13.5 years. In the study, each subject underwent neurosurgery: “four tiny burr holes, drilled through the wrinkle lines above the eyebrows into the skull, to clear a pathway to the brain. But only half received injections of fetal cells into the putamen, the region of the brain that controls movement; the other half received nothing. One year later, three members of the placebo group said their symptoms had improved.” In two-thirds of the transplant recipients, the fetal tissue took hold and seemed to establish a new network to produce the missing neurochemical dopamine.

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Lee, Susan. "Insights Learned From Teaching Pathophysiology on the World Wide Web. Yucha C, Princen T (University of Florida College of Nursing, University of Colorado Health Sciences Center). J Nurs Educ. 2000;39:68-72." Journal of Physical Therapy Education 14, no. 2 (2000): 47. http://dx.doi.org/10.1097/00001416-200007000-00011.

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Kozlov, Yu A., K. A. Kovalkov, V. M. Kapuller, et al. "THORACOSCOPIC TREATMENT OF ESOPHAGEAL ATRESIA: 18-YEARS INTERNATIONAL EXPERIENCE IN 775 PATIENTS IN FIVE CHILDREN’S SURGERY CENTERS." Pediatria. Journal named after G.N. Speransky 100, no. 3 (2021): 240–47. http://dx.doi.org/10.24110/0031-403x-2021-100-3-240-247.

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The paper presents a synthesis of the multicenter retrospective comparative study of the treatment of patients with esophageal atresia (EA) from 5 children's hospitals located in different countries of the world. Materials and methods of research: The study examined the results of surgical treatment of 775 patients with EA who were treated in 5 children’s hospitals located in Russia, USA and Europe: Ivano-Matreninskaya Children's Clinical Hospital, Irkutsk (Russia) – 126 patients; Children's Hospital of the Rocky Mountains, Denver (Colorado, USA) – 143, Pirogov Russian National Research Medical University, Moscow (Russia) – 175, University Medical Center, Utrecht (Netherlands) – 173, University of Medicine, Wroclaw (Poland) – 158 patients. The study lasted 18 years, from the very beginning of technology adoption in these hospitals and endied in December 2018 (from 2000 to 2018). In relation to patients, uniform technological methods of performing thoracoscopic anastomosis of the esophagus and recommendations for the postoperative management of such patients were applied, issued and controlled by all participants in this process. Results: in the analysis of treatment outcomes, mortality associated with surgery and mortality that had no causal link with surgery were considered. Mortality associated with surgical intervention in the presented treatment series did not differ statistically significantly and amounted to 0,8% (minimum – 0,0%, maximum – 1,7%, p=0,320). Non-operation fatalities varied statistically significantly and ranged from 0,0% to 4,4% (weighted average – 3,0%, p=0,030), but a pairwise comparison with the Benjamini-Hochberg amendment shows no statistically significant differences between the cities of the study. Anastomotic leakage (failure) rate was comparable and was detected in 5,8% of cases (minimum 2,9%, maximum 9,7%, p=0,059). Statistically significant differences were found in the following parameters: anastomotic stenosis developed in 10,3–39,9% of cases (weighted average – 20,1%, p<0,001); fistula recanalization was recorded in 2,7% of patients (minimum – 0,7%, maximum – 8,1%, p<0,001); the need for fundoplication existed in 14,3% of patients (minimum – 2,5%, maximum – 26,0%, p<0,001); the level of detection of tracheomalacia also differed in the presented treatment series and ranged from 0,0% to 9,2% (weighted average – 3,7%, p<0,001). Thus, the use of thoracoscopy for the treatment of EA ensures a low level of postoperative mortality, a low incidence of early and late postoperative complications. Conclusion: thoracoscopic EA reconstruction can be safely performed by experienced endoscopic surgeons from different centers, united by one technology for performing endosurgical operations in newborns and infants.

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Nooraie, Reza Yousefi, Bethany Kwan, Elissa Orlando, and Nancy M. Bennett. "11492 Mapping CTSA hub activities across the EQ-DI framework to discover opportunities for interaction between health equity and dissemination & implementation science; the case of University of Colorado and University of Rochester." Journal of Clinical and Translational Science 5, s1 (2021): 74. http://dx.doi.org/10.1017/cts.2021.593.

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ABSTRACT IMPACT: This study provides a framwork to inform and organize health equity efforts and initiatives at CTSA institutes. OBJECTIVES/GOALS: to map the activities of the Clinical and Translational Science Award (CTSA) Program hubs across the EQ-DI framework, to depict opportunities for interaction between health equity and dissemination & implementation (D&I) science. METHODS/STUDY POPULATION: The EQ-DI framework demonstrates the dynamic interaction between D&I science and health equity. Health equity could be a lens to sensitize and inform D&I planning (through goal-setting and team development), execution (through ‘adaptation’ and D&I strategies), and evaluation (through incorporating health equity in D&I outcome assessment). On the other hand, D&I models, methods, and study designs can operationalize dissemination and implementation of evidence-based interventions to improve equity. Stakeholder engagement is at the center of the framework to inform and direct the sensitization and operationalization cycles. RESULTS/ANTICIPATED RESULTS: We reviewed the activities of Colorado Clinical & Translational Sciences Institute (CCTSI) and University of Rochester Clinical and Translational Science Institute (UR CTSI) to improve health equity and mapped them across the EQ-DI framework. The sensitizing activities included health equity training, eliciting community priorities, and inclusion of health equity as a critical axis in funding mechanisms. The operationalizing activities included D&I methodological training and consultation, collaborative team science, and funding mechanisms to support implementation of health equity EBIs. Community engagement through studios, community liaisons, and consults was a core priority guiding sensitizing and operationalizing activities. DISCUSSION/SIGNIFICANCE OF FINDINGS: The CTSA Program has been a champion for community engagement and translational collaboration to improve individual and population health. CTSA hubs provide infrastructure and resources to facilitate equity-focused D&I.

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De Magalhaes Filho, C. Daniel, Chung-Wein Lee, Nikolai Suslov, Jerry Fong, and Miguel Garcia-Guzman. "622 PD-L1 is a potential predictive biomarker for response to RM-1929 treatment in recurrent head and neck squamous cell carcinoma patients." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A658. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0622.

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BackgroundRM-1929 is an antibody-dye conjugate comprised of cetuximab covalently linked to the photoactivable dye, IRDye® 700DX (IR700). After systemic infusion of RM-1929, illumination of the tumor with 690 nm non-thermal red light activates the drug and results in targeted and rapid tumor necrosis. Previous preclinical data have shown that RM-1929 treatment triggers immunogenic cell death and activates the innate and adaptive immune response. A retrospective analysis of PD-L1 expression from the phase I/IIa clinical trial in patients with recurrent head and neck squamous cell carcinoma (rHNSCC) (NCT02422979) was conducted. The analysis explored correlations of PD-L1 expression, including combined proportion score (CPS) and tumor proportion score (TPS), with clinical outcomes such as response rate and overall survival.MethodsPD-L1 expression prior to RM-1929 treatment was assessed by immunohistochemistry in 18 out of 30 patients enrolled in Part II of the trial, based on sample availability. PD-L1 expression was evaluated using TPS and CPS. Responders were defined as patients that achieved complete response or partial response, and non-responders had either stable disease or progressive disease. Overall survival (OS) was analyzed using the Kaplan-Meier method.ResultsResponders (n=10) had a TPS of 4.3±2.4 (mean±SEM), which was substantially lower than in non-responders (n=8) with a TPS of 39.4±11.8. Similarly, CPS was lower in responders (8.6±3.6) compared to non-responders (50.0±13.5). The best target response rate for all patients included in this analysis was 56%. Patients with CPS=40 had a response rate of 76.9% (n=13) compared to 0% in patients with CPS>40 (n=5). This suggests that a CPS cut-off of =40 led to enrichment of the best target response rate. The median OS of patients with CPS=40 (13.0±0.8 months) was also higher than in patients with CPS>40 (3.1±0.8 months) and in all patients (12.0±2.9 months).ConclusionsThese results suggest that rHNSCC patients with lower PD-L1 expression levels may be more responsive to RM-1929 treatment and CPS/TPS could potentially be predictive biomarkers in identifying patients with a higher probability of benefiting from this treatment. Given the limited number of patients in this analysis, additional clinical trials will be needed to validate PD-L1 expression as an effective predictive biomarker for RM-1929 treatment.AcknowledgementsThe authors would like to thank all patients and their families for their participation in this trial. The authors would also like to thank the following investigators for the contribution of samples included in this trial analysis: Dr. David Cognetti (Thomas Jefferson University Hospital), Dr. Ann M Gillenwater (University of Texas MD Anderson Cancer Center), Dr. Mary Jo Fidler (Rush University Medical Center), Dr. Samith T. Kochuparambil (Virginia Piper Cancer Institute ), Dr. John Campana (University of Colorado Head and Neck Specialists), and Dr. Nilesh R. Vasan (University of Oklahoma Health Sciences Center).Trial RegistrationNCT02422979Ethics ApprovalThe trial was approved by the following Instution Ethics Boards and IRB# as listed: UCSF Institutional Review Board (#17-21904), Thomas Jefferson University, IRB (#16C.328), University of Oklahoma Health Sciences Center Institutional Review Board (#5723), University of Texas MD Anderson Cancer Center - Institutional Review Board (#IRB 2 IRB00002203), Quorum Review IRB (#30458/1), Rush University Medical Center Institutional Review Board (#15030601-IRB01), and Catholic Health Initiatives Institute for Research and Innovation (CIRI) Institutional Review Board (CHIRB) (# IRB00009715).ConsentN/A

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23

Kuzela, Donald C., and Wendell C. Speers. "Heterotopic endometrium of the fallopian tube**Supported in part by grant CA-15823 from the National Institutes of Health, Bethesda, Maryland and by a gift to the Department of Pathology, University of Colorado Health Sciences Center, from the R.J. Reynolds Industries, Inc., Winston-Salem, North Carolina." Fertility and Sterility 44, no. 4 (1985): 552–53. http://dx.doi.org/10.1016/s0015-0282(16)48933-8.

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Hazuka, M. B., W. D. Burleson, D. N. Stroud, C. E. Leonard, K. O. Lillehei, and J. J. Kinzie. "Multiple brain metastases are associated with poor survival in patients treated with surgery and radiotherapy." Journal of Clinical Oncology 11, no. 2 (1993): 369–73. http://dx.doi.org/10.1200/jco.1993.11.2.369.

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PURPOSE A retrospective analysis was performed to evaluate the role of surgery in the management of patients with solitary and multiple brain metastases. PATIENTS AND METHODS Between 1980 and 1990, 46 patients underwent surgical resection of brain metastases at the University of Colorado Health Sciences Center. All but two patients received postoperative whole-brain radiotherapy to a median total dose of 30 Gy (range, 11.4 Gy to 50.0 Gy). Lung was the most common (56%) primary site and adenocarcinoma was the most common (46%) tumor histology. Twenty-eight of 46 patients (61%) had solitary metastases, while the remaining 18 patients had two or more foci. RESULTS The median survival of all 46 patients was 11 months, and the 1- and 2-year survival rates were 40% and 12%, respectively. Moderately severe to severe neurologic impairment at the time of diagnosis and the presence of multiple brain metastases were associated with a significantly poorer survival. In patients with solitary metastasis, gross total resection and adenocarcinoma tumor histology significantly prolonged survival, whereas primary tumor site, the presence of active extracranial disease, and radiation dose had no significant effect on survival. CONCLUSION These results are consistent with a recent randomized study supporting the role of surgery and whole-brain radiation therapy in the management of patients with solitary brain metastases. We would caution against the generalization of this concept to patients with two or more brain metastases.

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PERSU, ALEXANDRE, OLIVIER DEVUYST, NATHALIE LANNOY, et al. "CF Gene and Cystic Fibrosis Transmembrane Conductance Regulator Expression in Autosomal Dominant Polycystic Kidney Disease." Journal of the American Society of Nephrology 11, no. 12 (2000): 2285–96. http://dx.doi.org/10.1681/asn.v11122285.

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Abstract. Disease-modifying genes might participate in the significant intrafamilial variability of the renal phenotype in autosomal dominant polycystic kidney disease (ADPKD). Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is a chloride channel that promotes intracystic fluid secretion, and thus cyst progression, in ADPKD. The hypothesis that mutations of the CF gene, which encodes CFTR, might be associated with a milder renal phenotype in ADPKD was tested. A series of 117 unrelated ADPKD probands and 136 unaffected control subjects were screened for the 12 most common mutations and the frequency of the alleles of the intron 8 polymorphic Tn locus of CF. The prevalence of CF mutations was not significantly different in the ADPKD (1.7%, n = 2) and control (3.7%, n = 5) groups. The CF mutation was ΔF508 in all cases, except for one control subject (1717-1G A). The frequencies of the 5T, 7T, and 9T intron 8 alleles were also similar in the ADPKD and control groups. Two additional patients with ADPKD and the ΔF508 mutation were detected in the families of the two probands with CF mutations. Kidney volumes and renal function levels were similar for these four patients with ADPKD and ΔF508 CFTR (heterozygous for three and homozygous for one) and for control patients with ADPKD collected in the University of Colorado Health Sciences Center database. The absence of a renal protective effect of the homozygous ΔF508 mutation might be related to the lack of a renal phenotype in CF and the variable, tissue-specific expression of ΔF508 CFTR. Immunohistochemical analysis of a kidney from the patient with ADPKD who was homozygous for the ΔF508 mutation substantiated that hypothesis, because CFTR expression was detected in 75% of cysts (compared with <50% in control ADPKD kidneys) and at least partly in the apical membrane area of cyst-lining cells. These data do not exclude a potential protective role of some CFTR mutations in ADPKD but suggest that it might be related to the nature of the mutation and renal expression of the mutated CFTR.

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Chen, Robert, Glen Peterson, Diana Vucurevich, Choon-kee Lee, William Robinson, and Han Myint. "Treatment of Extranodal Marginal Zone Lymphoma and Primary Cutaneous B Cell Lymphoma with Rituximab: A Single Institution Experience." Blood 110, no. 11 (2007): 4502. http://dx.doi.org/10.1182/blood.v110.11.4502.4502.

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Abstract Extranodal marginal zone lymphoma is a low grade B cell lymphoma. It comprises about 5% of all non-hodgkin’s lymphoma. They typically present in the lung, thyroid, breast, lacrimal and salivary gland, orbit, and skin. Primary cutaneous B cell lymphoma is an extremely rare form of lymphoma with 3 histological variants: marginal zone, follicular, and diffuse large B cell. In general, they have a high remission rate with overall survival up to 80% at 10 years. At the University of Colorado Health Sciences Center, we have seen ten such cases from July 2005 to July 2007. There is no standard treatement for either extranodal marginal zone lymphoma or primary cutaneous B cell lymphoma, but prior reports have shown long term survival with surgery, radiation, and chemotherapy. Most institutions use radiation therapy as the main modality after excisional biopsy. There is one report by Gitelson et al (leuk lymphoma 2006) using single agent rituximab as the only modality. Out of the ten cases at our institution, six cases were primary cutaneous B cell lymphoma (4 marginal zone, 1 follicular, one diffuse large B cell), and four cases were extranodal marginal zone lymphoma. Four out of six cases of primary cutaneous B cell lymphoma and three out of four of extranodal marginal zone lymphoma was treated with single agent rituximab. Two out of the six cases of primary cutaneous B cell lymphoma and one out of four of extranodal marginal zone lymphoma was treated with radiation. Patients were given induction therapy rituximab at the dose of 375mg/m2 IV weekly x 4 weeks and maintenance therapy at 375 mg/m2 IV every two to three month interval for 8 cycles. 7 patients were given rituximab single agent. All achieved CR (100%) immediately after induction therapy at 1 month. They were also given maintenance treatment. No relapses has occured at the medium follow up of 7 month (3–24 month). Our preliminary result supports the recent report of single agent rituximab. Even though extranodal marginal zone lymphoma is a rare disorder and primary cutaneous B cell lymphoma even more rarer, we feel that a well designed prospective randomized trial would determine the role of rituximab for this disease.

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Dymond, John H. "Preface." Pure and Applied Chemistry 79, no. 8 (2007): iv. http://dx.doi.org/10.1351/pac20077908iv.

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The 19th International Conference on Chemical Thermodynamics (ICCT-19) took place as part of THERMO International 2006, together with the 16th Symposium on Thermophysical Properties and the 61st Calorimetry Conference, from 30 July to 4 August 2006 at the University of Colorado, Boulder, CO, USA. Dr. W. M. Haynes was President of the Executive Board of THERMO International 2006, and Drs. M. Frenkel, R. D. Chirico, and J. W. Magee were the organizers of ICCT. Overall, 768 speakers submitted the abstracts of their presentations, including about 30 students and 11 exhibitors, from 62 countries (235 from North America, 341 from Europe, 76 from Japan, and 33 from China). About 65 % of the participants were from academia and 15 % from industry, with 20 % from governmental and international organizations.These individual conferences have an overlap of areas of interest, but this was the first time that they have been held jointly at the same site. This provided a unique opportunity for researchers and practitioners worldwide to meet and discuss a broad range of scientific problems in the fields of thermodynamics and thermophysical properties for a wide variety of systems, with applications in chemistry and other scientific and engineering disciplines.After the official opening ceremony, there was an invited keynote presentation by Prof. W. A. Wakeham from the University of Southampton, Southampton, UK, entitled "Thermophysical property measurements: The journey from accuracy to fitness for purpose". The Rossini Award lecture was given by Prof. A. Navrotsky on "Calorimetry of nanoparticles, surfaces, interfaces, thin films, and multilayers".The ICCT program consisted of nine symposia, some of which were held jointly with the other conferences. The plenary lecturers and invited speakers in these symposia, and the titles of the plenary lectures, were as follows:Electrolyte and Non-Electrolyte Solution Thermodynamics: J. M. Prausnitz (plenary), "Some promising frontiers in the thermodynamics of protein solutions"; C. G. Panayiotou, P. R. Tremaine, and T. Kimura (invited)Ionic Liquids: K. Seddon (plenary); "The mark of an educated mind"; L. P. N. Rebelo and C. J. Peters (invited)Molecular Modelling, Including Simulation: D. Evans (plenary), "The fluctuation and non-equilibrium free energy theorems: Theory and experiment"; H. Tanaka, J. Errington, and A. Klamt (invited)Thermochemistry and Molecular Energetics: J. A. de Sousa Martinho Simões (plenary), "Energetics of free radicals: Bridges between gas-phase and solution data"; W. E. Acree, Jr. and J. S. Chickos (invited)Thermodynamics and Properties in the Biological, Medical, Pharmaceutical, Agricultural, and Food Sectors: P. L. Privalov (plenary), "Thermodynamic problems in structural molecular biology"; J. M. Sanchez-Ruiz and H. H. Klump (invited)Databases, Data Systems, Software Applications, and Correlations: M. Satyro (plenary), "Life, data and everything"; R. L. Rowley and R. Sass (invited)Phase Equilibrium, Supercritical Fluids, and Separation Technologies: S. Sandler (plenary), "Computational quantum mechanics: An under-utilized tool for applied thermodynamics"; L. F. Vega and R. P. Danner (invited)Colloid and Interface Science: L. Piculell (plenary), "Controlling structure in associating polymer-surfactant mixtures"; H. K. Yan and K. Lohner (invited)New Materials: V. K. Pecharsky (plenary), "Structure, mechanism, and thermodynamics of novel rare-earth-based inter-metallic materials"; C. Staudt-Bickel and J. Pons (invited)The plenary lectures, with the exception of the lecture by Prof. K. Seddon, are published in this issue.There were workshops on New Experimental Techniques, with Profs. C. Schick and J. P. M. Trusler as invited speakers, on Properties and Processes for a Hydrogen-Based Economy, where Prof. C. J. Peters was the invited speaker, and on Thermodynamic Frontiers and Education, with Profs. R. N. Lichtenthaler and R. Battino as invited speakers.In addition, there was a workshop on the Thermodynamic Properties of Hydration (with Prof. V. Majer as invited speaker), software demonstrations, and two afternoon poster sessions, with over 400 posters. The sessions were held in the well-appointed Stadium Club, against the beautiful backdrop of the Flatirons to the west and the plains stretching across to the east. IUPAC had donated three poster prizes, a framed certificate signed by IUPAC President Brian Henry, a copy of the IUPAC "Gold Book" and a two-year subscription to Chemistry International. These were awarded to Martinez-Herrera Melchor (Mexico), Lisa Ott (USA), and Isabel Marrucho (Spain).Doctorate awards were presented by the International Association of Chemical Thermodynamics (IACT), with sponsorship from Elsevier. The four recipients were M. Fulem (Prague, Czech Republic), Y. U. Paulechka (Minsk, Belarus), E. Asabina (Nizhni Novgorod, Russian Federation), and J. Xu (Trondheim, Norway). They each received a certificate, plus a cash prize of $500, and presented their papers at the conference.All the lectures demonstrated how chemical thermodynamics is making, and will continue to make, very significant contributions to the rapidly developing interdisciplinary fields such as the life sciences, new materials, medicine and pharmacy, new energy resources, the environment, separation technologies, agriculture, green chemistry, and so on. These are all extremely important issues for scientists worldwide, and particularly for those who are in developing or economically disadvantaged countries. The opportunity for face-to-face discussion and communication with scientists from developed countries was a great benefit, which will lead to further research and improved education.The weather was most pleasant for the conference. This, together with the attractive setting of the campus, the welcoming reception, the conference banquet at the National Center for Atmospheric Research, and the high standard of the presentations, made this a memorable conference. In addition, there was a full program of tours for accompanying persons, which included a visit to the mile-high city (Denver). Our thanks are extended to the Conference Chair and Co-chairs, and to all members of the local Organizing Committee, the members of the International Advisory Committee, and the members of the International Scientific Committee. We are most grateful to IUPAC, the International Association of Chemical Thermodynamics, the National Institute of Standards and Technology, the American Society of Mechanical Engineers, and the American Institute of Chemical Engineers, Elsevier, Honeywell, and Mettler Toledo for sponsoring THERMO International 2006.Thermodynamics will continue to be an important area of research for many years to come, with a wide range of applications from chemical engineering to the biosciences. We look forward to the presentation and discussion of the results of further advances in chemical thermodynamics at the next ICCT, which will take place in Warsaw, Poland in August 2008.John H. DymondConference Editor

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Lundin, Bjorn, Walter Hong, David Raunig, et al. "Effect on Joint Health of Routine Prophylaxis with Bayer’s Sucrose-Formulated Recombinant Factor VIII (rFVIII-FS) in Adolescents and Adults Previously Treated on Demand: MRI Analyses from the 3-Year Spinart Study." Blood 124, no. 21 (2014): 2854. http://dx.doi.org/10.1182/blood.v124.21.2854.2854.

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Abstract Introduction: The benefits of primary prophylaxis with a factor VIII (FVIII) product in pediatric patients with severe hemophilia A are well established. Fewer data are available on the benefits of secondary prophylaxis (started after ≥2 joint bleeds but before the onset of documented joint disease). The 3-year SPINART study compared the efficacy and safety of routine prophylaxis vs on-demand treatment in adolescents and adults with severe hemophilia A, all of whom were treated with Bayer's sucrose-formulated recombinant FVIII (rFVIII-FS). Primary 3-year data on magnetic resonance imaging (MRI) joint assessments in SPINART have been recently reported. Here we present additional analyses of the SPINART 3-year MRI data. Methods: SPINART was a 3-year, randomized, controlled, parallel-group, open-label study conducted at 31 centers in the United States, Bulgaria, Romania, and Argentina. Male patients aged 12–50 years were eligible for SPINART if they had severe hemophilia A (FVIII:C <1%), ≥150 exposure days to any FVIII product, no current evidence or history of FVIII inhibitors, no prophylaxis for >12 consecutive months in the past 5 years, and 6–24 documented bleeding events or treatments in the previous 6 months. Eligible patients were randomly assigned 1:1 to on-demand treatment or prophylaxis. Patients assigned to prophylaxis received rFVIII-FS 25 IU/kg 3 times weekly; in patients with ≥12 bleeding episodes per year, dose increases of 5 IU/kg were permitted at years 1 and 2. All patients underwent MRI assessments at baseline and year 3 to evaluate the structure of 6 index joints (knees, ankles, elbows). Each MRI was read by 3 radiologists blinded to treatment assignment who independently completed the Extended MRI (eMRI) scale. The eMRI scale has 2 domains (soft tissue, osteochondral), and total eMRI scores range from 0 to 45 based on soft-tissue domain scores of 0 to 9 and osteochondral domain scores of 0 to 36; higher eMRI scores indicate greater joint structural damage. Change from baseline to year 3 in eMRI total score based on all 6 index joints was analyzed for the following baseline characteristics: region (US vs non-US), age (≤29 vs >29 years), and number of bleeding episodes in the previous 6 months (<8 vs ≥8). For patients with target joints, change from baseline to year 3 in eMRI scores in the worst target joint was analyzed using analysis of covariance adjusted for bleeding frequency during the prior 6 months. Results: Eighty-four patients (42 per treatment group) were enrolled in the SPINART study. Target joint analysis data for patients with target joints who completed the study were available for 28 on-demand and 20 prophylaxis patients. Least squares (LS) mean change from baseline to year 3 in eMRI total score in the analyzed target joint was 0.91 (95% CI, –0.06 to 1.88) and 1.09 (95% CI, 0.12–2.07) for the on-demand and prophylaxis groups, respectively; the difference was not statistically significant (LS mean difference, 0.18; 95% CI, –1.05 to 0.70; P=0.68). Results for the subgroup analyses are shown in the Table. Table.eMRI Total Score (Mean ± SD Change From Baseline to Year 3)Region Age, y Number of Bleeds in Past 6 MonthsUSNon-US≤29 >29 <8≥8On demand0.56±0.77 (n=14)1.24±1.35 (n=16)1.34±1.21 (n=18)0.29±0.70 (n=12)0.88±0.83 (n=4)0.93±1.20 (n=26)Prophylaxis1.05±1.36 (n=10)0.61±1.70 (n=22)0.46±1.88 (n=17)1.08±1.15 (n=15)0.91±0.69 (n=11)0.67±1.91 (n=21) Conclusions: Over 3 years of treatment, change in eMRI total score for target joints was similar for the on-demand and prophylaxis groups in SPINART. In the prophylaxis group, progression of joint structural damage after 3 years of treatment, as indicated by changes in eMRI total scores based on all 6 index joints, did not differ by number of bleeding episodes in the preceding 6 months but appeared to be less pronounced among younger patients compared with older patients and among those in the non-US group compared with the US group; results by age and region in the on-demand group were opposite of those seen in the prophylaxis group. These results must be interpreted with caution given the small patient numbers, the possibility that the study duration was not sufficient to show changes on MRI, and the fact that target joints were assessed. These results may underscore the importance of preventing target joint development and show that once a target joint has developed, MRI may not show reversal of pre-existing damage despite prophylaxis. Disclosures Lundin: Bayer: Received reimbursement from Bayer for symposium attendance, Received reimbursement from Bayer for symposium attendance Other; Bayer HealthCare : Employed by the Center for Medical Imaging and Physiology at Skåne University Hospital and is under contract to Bayer HealthCare for work performed for SPINART Other. Hong:Bayer HealthCare: Employment. Raunig:Employed by ICON Medical Imaging and is under contract to Bayer HealthCare for work performed for SPINART on the validation of the eMRI scale and Colorado Adult Joint Assessment Scale.: Consultancy. Engelen:Bayer HealthCare: Employment. Peterfy:Spire Sciences, Inc.: Owner of Spire Sciences, Inc., which provides central image analysis services to pharmaceutical and medical device companies. Other. Werk:Bayer HealthCare: Under contract to Bayer HealthCare for work performed for SPINART. Other. Manco-Johnson:Bayer: Membership on an entity's Board of Directors or advisory committees.

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Winski, Shannon L., Elizabeth Swann, Robert H. J. Hargreaves, et al. "Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones 1 2 1In accordance with the policy of the University of Colorado Health Sciences Center, D.R., R.H.J.H., and J.B. declare a patent interest in RH1. 2Abbreviations: MMC, mitomycin C; NQO1, NAD(P)H:quinone oxidoreductase 1 or DT-diaphorase; MeDZQ, 2,5-diaziridinyl-3,6-dimethyl-1,4-benzoquinone; DCPIP, 2,6-dichlorophenol-indophenol; MTT, thiazolyl blue; P450R, NADPH:cytochrome P450 reductase; b5R, NADH:cytochrome b5 reductase; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer; FBS, fetal bovine serum; and MEM, Eagle’s minimum essential medium." Biochemical Pharmacology 61, no. 12 (2001): 1509–16. http://dx.doi.org/10.1016/s0006-2952(01)00631-1.

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"CORE Center Report University of Colorado at Denver and Health Sciences Center: Obesity in Medical School Curriculum." Obesity Management 2, no. 6 (2006): 235. http://dx.doi.org/10.1089/obe.2006.2.235.

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"Program: American association for cancer education 23rd annual meeting brown palace hotel and university of Colorado health sciences center Denver, Colorado October 5-8, 1989 Thursday, October 5, 1989." Journal of Cancer Education 4, no. 3 (1989): 211–13. http://dx.doi.org/10.1080/08858198909528003.

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"The effect of gender on gallbladder motility in obese and non-obese subjects . Section of Hepatology and Hepatobiliary Research Center, Dept. of Medicine, General Clinical Research Center, University of Colorado Health Sciences Center, Denver, CO." Hepatology 22, no. 4 (1995): A502. http://dx.doi.org/10.1016/0270-9139(95)95728-6.

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"New Health & Wellness Center at the University of Colorado Denver." Obesity and Weight Management 5, no. 4 (2009): 179–80. http://dx.doi.org/10.1089/obe.2009.0410.

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"MRI predictors of early conversion to clinically definite MS in the CHAMPS placebo group. CHAMPS Study Group.**Dr. Jack H. Simon, Department of Radiology, University of Colorado Health Science Center, Campus Box A-034, 4200 E. Ninth Ave., Denver, CO 80262. E-mail: jack.simon@uchsc.edu, USA Neurology 2002;59:998–1005." American Journal of Ophthalmology 135, no. 3 (2003): 424. http://dx.doi.org/10.1016/s0002-9394(02)02264-x.

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Khuntia, Jiban, Jahangir Karimi, Mohan Tanniru, and Arlen Meyers. "The University of Colorado Digital Health Consortium Initiative: A Collaborative Model of Education, Research and Service." Journal of Commercial Biotechnology 20, no. 3 (2014). http://dx.doi.org/10.5912/jcb651.

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This article describes the initiative and actions related to establishing a Digital Health Consortium (DHC) at the University of Colorado Denver. The consortium is a part of the Center for Information Technology Innovation (CITI) in the Business School.Â The objective is to augment existing information systems program offerings in health information technology with the support of industry affiliates and other partners of the university. Â The CITI-DHC is an industry-academia led initiative with a mission to accelerate digital health transformation through education, research, and service. We illustrate the vision and plan for the consortium, that will be fulfilled with academic and industry stakeholders, and who will be engaged with the platform to support digital health care innovations through collaborations.Â Â

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"Abstracts 1 1Abstracts is coordinated by Chris Colwell, md, of the Denver Health Medical Center, Denver, Colorado, and Stephen R. Hayden, md, of the University of California San Diego Medical Center, San Diego, California. Abstracts are prepared by the Emergency Medicine residents of the Denver Affiliated Residency in Emergency Medicine, Denver, Colorado, and the University of California-San Diego Medical Center, San Diego, California." Journal of Emergency Medicine 22, no. 2 (2002): 217–21. http://dx.doi.org/10.1016/s0736-4679(01)00473-5.

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"Robert William Schrier, MD, of the University of Colorado Health Sciences Center, Talks to the Editor." Baylor University Medical Center Proceedings 12, no. 1 (1999): 17–24. http://dx.doi.org/10.1080/08998280.1999.11930137.

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"International Certificate Program in Caring and Healing The University of Colorado Health Sciences Center School of Nursing." Nursing Philosophy 5, no. 1 (2004): 92. http://dx.doi.org/10.1111/j.1466-769x.2004.00157.x.

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Abate, Claire, Ashley Miknis, Jordan Pryczynski, et al. "Nutrition Education for Transgender Individuals During Transition (P04-001-19)." Current Developments in Nutrition 3, Supplement_1 (2019). http://dx.doi.org/10.1093/cdn/nzz051.p04-001-19.

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Abstract Objectives Over 90 million people around the world identify as transgender1. The glaring lack of published nutrition research on the topic of transgender health drove our proposal to conduct this needs assessment. Additionally, we sought to determine whether medical nutrition intervention was desired, as well as uncovering any metabolically relevant side effects of hormone therapy. Methods To carry out our research we obtained IRB approval from Metropolitan State University of Denver at Auraria Campus. Following approval we then constructed a thirteen question survey via Qualtrics Software that was live for three weeks. Our team distributed flyers across the Auraria campus which also houses University of Colorado Denver and Community College of Denver. We also reached out to local partners such as It Takes a Village, The Name Change, and the LGBTQ Center at the Auraria Campus who were able to email a link to our survey to members of their outreach programs. Results Despite our efforts, our population size was fewer than desired as we only received responses from 12 individuals. Yet we were able to glean several trends from the data pool. The significant age bracket of respondents was between the ages of 18–29 with the majority of those within the 20–29 age bracket. It can then be correlated as to the number of years having received hormone replacement therapy being between 1–5 years as the age population was fairly low and thus could not have reasonably been on HRT for more than 5 years. 100% of respondents indicated that they would like additional counseling and information, specifically in regards to drug-diet interactions, weight management and supplementation. 100% of our respondents also indicated that they had not received any formal nutrition care during their transition. Conclusions With proper tools, time, and guidance we could further explore the medical nutritional needs across a multitude of transitioning phases. Main areas of focus should include sensitivity training, current health status, and proper monitoring of health changes specifically during the first 5 years of transitioning. It should be restated that transitioning individuals should be treated with a full integrative health care team. Funding Sources Our research was conducting as a Senior Capstone Project through the Metropolitan State University of Denver and therefore did not have any funding sources.

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Abate, Claire, Ashley Miknis, Jordan Pryczynski, et al. "Nutrition Education for Transgender Individuals During Transition (P04-001-19)." Current Developments in Nutrition 3, Supplement_1 (2019). http://dx.doi.org/10.1093/cdn/nzz047.p04-001-19.

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Abstract Objectives Over 90 million people around the world identify as transgender.1 The glaring lack of published nutrition research on the topic of transgender health drove our proposal to conduct this needs assessment. Additionally, we sought to determine whether medical nutrition intervention was desired, as well as uncovering any metabolically relevant side effects of hormone therapy. Methods To carry out our research we obtained IRB approval from Metropolitan State University of Denver at Auraria Campus. Following approval we then constructed a thirteen question survey via Qualtrics Software that was live for three weeks. Our team distributed flyers across the Auraria campus which also houses University of Colorado Denver and Community College of Denver. We also reached out to local partners such as It Takes a Village, The Name Change, and the LGBTQ Center at the Auraria Campus who were able to email a link to our survey to members of their outreach programs. Results Despite our efforts, our population size was fewer than desired as we only received responses from 12 individuals. Yet we were able to glean several trends from the data pool. The significant age bracket of respondents was between the ages of 18–29 with the majority of those within the 20–29 age bracket. It can then be correlated as to the number of years having received hormone replacement therapy being between 1–5 years as the age population was fairly low and thus could not have reasonably been on HRT for more than 5 years. 100% of respondents indicated that they would like additional counseling and information, specifically in regards to drug-diet interactions, weight management and supplementation. 100% of our respondents also indicated that they had not received any formal nutrition care during their transition. Conclusions With proper tools, time, and guidance we could further explore the medical nutritional needs across a multitude of transitioning phases. Main areas of focus should include sensitivity training, current health status, and proper monitoring of health changes specifically during the first 5 years of transitioning. It should be restated that transitioning individuals should be treated with a full integrative health care team. Funding Sources Our research was conducting as a Senior Capstone Project through the Metropolitan State University of Denver and therefore did not have any funding sources.

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"A novel cis-acting element in a liver cytochrome P450 3A gene confers paradoxical, synergistic induction by glucocorticoids plus antiglucocorticoids ?* Department of Medicine, Hepatobiliary Research Center, Section of Medical Toxicology, University of Colorado Health Sciences Center* and Department of Pathology, Medical College of Virginia?" Hepatology 22, no. 4 (1995): A301. http://dx.doi.org/10.1016/0270-9139(95)94926-7.

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