Journal articles: 'University of Southern California Los Angeles'

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Baker, Laura A., Mafalda Barton, Dora Isabel Lozano, Adrian Raine, and James H. Fowler. "The Southern California Twin Register at the University of Southern California: II." Twin Research and Human Genetics 9, no. 6 (December 1, 2006): 933–40. http://dx.doi.org/10.1375/twin.9.6.933.

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AbstractThe Southern California Twin Register was initiated in 1984 at the University of Southern California, and continues to grow. This article provides an update of the register since it was described in the 2002 special issue of this journal. The register has expanded considerably in the past 4 years, primarily as a result of recent access to Los Angeles County birth records and voter registration databases. Currently, this register contains nearly 5000 twin pairs, the majority of whom are school age. The potential for further expansion in adult twins using voter registration records is also described. Using the Los Angeles County voter registration database, we can identify a large group of individuals with a high probability of having a twin who also resides in Los Angeles County. In addition to describing the expansion of register, this article provides an overview of an ongoing investigation of 605 twin pairs who are participating in a longitudinal study of behavioral problems during childhood and adolescence. Characteristics of the twins and their families are presented, indicating baseline rates of conduct problems, depression and anxiety disorders, and attention-deficit/hyperactivity disorder diagnoses which are comparable to nontwins in this age range.

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&NA;. "Department of Surgery, University of Southern California, and the Los Angeles County-University of Southern California Medical Center, Los Angeles, California." Survey of Anesthesiology 32, no. 2 (April 1988): 103???104. http://dx.doi.org/10.1097/00132586-198804000-00033.

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Darki, Leila, and Said R. Beydoun. "Delayed Appearance of Conduction Block in Multifocal Motor Neuropathy—A Case Report." US Endocrinology 13, no. 02 (2017): 99. http://dx.doi.org/10.17925/use.2017.13.02.99.

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Darki, Leila, and Said R. Beydoun. "Delayed Appearance of Conduction Block in Multifocal Motor Neuropathy—A Case Report." US Neurology 13, no. 02 (2017): 99. http://dx.doi.org/10.17925/usn.2017.13.02.99.

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Schneider, John H., Martin H. Weiss, and William T. Couldwell. "Development of neurosurgery in Southern California and the Los Angeles County/University of Southern California Medical Center." Journal of Neurosurgery 79, no. 1 (July 1993): 145–48. http://dx.doi.org/10.3171/jns.1993.79.1.0145.

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✓ The Los Angeles County General Hospital has played an integral role in the development of medicine and neurosurgery in Southern California. From its fledgling beginnings, the University of Southern California School of Medicine has been closely affiliated with the hospital, providing the predominant source of clinicians to care for and to utilize as a teaching resource the immense and varied patient population it serves.

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Fukumori, Ryan. "Projecting the Multiracial University." Pacific Historical Review 87, no. 3 (2018): 499–532. http://dx.doi.org/10.1525/phr.2018.87.3.499.

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During the 1960s, the University of California, Los Angeles (UCLA) hosted research surveys focused on two of Southern California’s largest communities of color: the Japanese American Research Project (JARP, 1962–1970) and the Mexican American Study Project (MASP, 1964–1968). While conceived in separate sectors of the university’s research apparatus, JARP and MASP together exemplify UCLA’s gradual institutionalization of racial diversity over the course of the decade. In the years before UCLA could claim a critical mass of nonwhite scholars and students, these projects inaugurated campus-community relations with local civil rights organizations as both collaborators and critics. Together, JARP and MASP demonstrate that the multiracial integration of California’s higher education system was a prolonged process, first requiring the state’s predominantly white public universities to develop institutional vocabularies of racial difference where none existed prior.

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Hughey, Jeffery R., and Kathy Ann Miller. "Molecular phylogenetic analysis of Sciadophycus stellatus (Rhodymeniales, Rhodophyta) supports its placement in the family Rhodymeniaceae." Phytotaxa 245, no. 4 (February 4, 2016): 297. http://dx.doi.org/10.11646/phytotaxa.245.4.7.

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The marine red alga Sciadophycus stellatus E.Y.Dawson (1945) (Figure 1) was described from specimens dredged at 40–50 meters from the Kellett Channel, south shore of Cerros Island (also known as Cedros Island), Baja California, Mexico (Dawson 1945). This uncommon subtidal species occurs in southern California, Baja California, Mexico and Isla Floreana, Galapagos Islands (as Fauchea rhizophylla Taylor) (Dawson 1945, Abbott and Hollenberg 1976, Millar 2001, Aguilar-Rosas et al. 2010). In California, S. stellatus has been collected in San Diego County (UC2003699) and Palos Verdes Peninsula, Los Angeles County (UC1882843), on the mainland coast of southern California and, more commonly, offshore from Santa Catalina (UC1471598), Santa Barbara (UC2034301), Anacapa (WTU-A-012879) and Santa Cruz Islands (UC1965240). In Mexico, in addition to the type locality, it has been collected from Isla Los Coronados (UC1574390), La Bufadora (Aguilar-Rosas et al. 2010), Isla Natividad (UC1882846), Punta Eugenia (US13095) and Bahia Tortugas (US42090), Baja California (distribution records, unless otherwise cited, are based on specimens in herbaria at the University of California at Berkeley [UC], University of Washington [WTU-A], and the Smithsonian Institution [US]).

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Bowlt, John E., and Elizabeth Durst. "“The Art of Concealing Imperfection”." Experiment 20, no. 1 (October 27, 2014): 118–45. http://dx.doi.org/10.1163/2211730x-12341261.

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The focus of the essay is on Léon Bakst’s activities in the usa, especially in Los Angeles in 1924, when he lectured at the University of Southern California and at the Biltmore Hotel. The essay also touches on Bakst’s interest in Hollywood and cinema as the “new” medium and on his popularity as a dress and textile designer.

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Wallach, Ruth. "Theater and Cabaret Collection Acquisitions at the University of Southern California, Los Angeles." Slavic & East European Information Resources 2, no. 2 (February 28, 2002): 25–27. http://dx.doi.org/10.1300/j167v02n02_04.

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Pogrund, R. L., D. L. Fazzi, and E. M. Schreier. "Development of a Preschool “Kiddy Cane”." Journal of Visual Impairment & Blindness 87, no. 2 (February 1993): 52–54. http://dx.doi.org/10.1177/0145482x9308700205.

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The American Foundation for the Blind's (AFB's) National Technology Center and the Orientation and Mobility Training Program at California State University, Los Angeles, worked jointly to develop and evaluate a “kiddy cane” for use with young blind children aged 2–6. The prototype cane was designed at AFB and field tested by orientation and mobility specialists in southern California who worked with young children. Initial modifications were made on the basis of feedback from the specialists. Ongoing evaluation from the field is desired to make further improvements in the cane.

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Dubose, Joseph J., Pedro G. R. Teixeira, Gustavo Recinos, Galinos Barmparas, Marcus Ottochian, Kenji Inaba, Patrizio Petrone, and Demetrios Demetriades. "An International Fellowship in Trauma Research and the Potential Benefits for Fellows, Sponsoring Institution, and the Global Trauma Community." American Surgeon 75, no. 4 (April 2009): 324–30. http://dx.doi.org/10.1177/000313480907500412.

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For over a decade, the Los Angeles County/University of Southern California Hospital has supported an international fellowship in trauma that provides research experience, education, and opportunity for clinical observation at a high-volume American College of Surgeons (ACS) designated Level I trauma center. We performed a descriptive study of the design, implementation, and results of an international fellowship in trauma and critical care. Fellows from 27 countries throughout the world have actively engaged in trauma research at Los Angeles County/University of Southern California Hospital. Our program involves intensive education and clinical observation components designed to facilitate dissemination of evidence-based trauma practices throughout the world by graduates. The majority of alumni responding to a survey returned to their countries of origin, remaining active in trauma care and research. Motivation for participation varied, but former fellows universally rated their experience highly and stated they would recommend the program to their colleagues. An international research fellowship in trauma and critical care provides foreign medical trainees opportunities for exposure to research and evidence-based practices at a high-volume trauma center. The program is designed to be beneficial to both the participating fellow and sponsoring institution; and is constructed to effectively promote improved trauma education and the dissemination of quality trauma practices internationally

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Robertson, Barbara D. "Hope From Ashes: The Creation of the NEC Society—An Interview With Jennifer Canvasser." Clinical Lactation 6, no. 4 (November 2015): 156–60. http://dx.doi.org/10.1891/2158-0782.6.4.156.

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Jennifer Canvasser has served on the Ecology Center’s children’s health, first food, and environmental health campaigns since 2010. She completed University of California, San Francisco’s Reach the Decision Makers Fellowship program in 2011, with a focus on reform of the Toxic Substances Control Act. In 2014, Jennifer founded the NEC Society, a nonprofit organization, after losing her son, Micah, to necrotizing enterocolitis. She is a regular contributor to The Huffington Post on parenting, health, and food justice issues. Jennifer completed her undergraduate studies at University of California, Los Angeles and earned her Master of Social Work from the University of Southern California with a focus on community organizing. This interview with Jennifer Canvasser was conducted in May of 2015 by Barbara D. Robertson and Barb Demske (Barbara Robertson’s intern). Barbara Robertson has a podcast, "All Things Breastfeeding," available on iTunes or her website, bfcaa.com.

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Hu, E., S. Hufford, R. Lukes, M. Bernstein-Singer, G. Sobel, P. Gill, L. Pinter-Brown, M. Rarick, P. Rosen, and R. Brynes. "Third-World Hodgkin's disease at Los Angeles County-University of Southern California Medical Center." Journal of Clinical Oncology 6, no. 8 (August 1988): 1285–92. http://dx.doi.org/10.1200/jco.1988.6.8.1285.

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The reported experience with Hodgkin's disease (HD) in the United States has come primarily from large referral centers that attract a predominantly white population of high socioeconomic status (SES). The majority of these patients had the nodular sclerosis (NS) histologic subtype and asymptomatic stage I/II disease. We have reviewed the records of 178 patients with HD seen within the past 17 years at Los Angeles County-University of Southern California Medical Center (LAC/USC), which is a nonreferral, government-operated facility. Our patient population was found to be heterogeneous, with 38% white, 22% black, and 36% Hispanic. Systemic "B" symptoms were noted in 62% of patients at diagnosis, and 63% had advanced disease (stage III or IV). NS pathologic subtype was present in only 52% of the group. Comparison between the races revealed: (1) Hispanics had a higher incidence of lymphocyte depleted subtype and less NS than whites (P less than .06); (2) whites had equal distribution between stages I/II and III/IV; (3) blacks and Hispanics presented more frequently with stage III/IV (P = .10); and (4) extranodal involvement occurred most often in bone in whites, and was equally distributed between liver, lung, and bone in blacks and Hispanics. We conclude that the lower SES, mixed racial population seen at our institution more closely resembles the reports of HD in Third-World countries and is characterized by advanced symptomatic disease. Further, the clinical pathologic characteristics of HD in the United States may vary significantly, depending upon the precise ethnic and socioeconomic status of the patients being served.

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Taly, N. "The Whittier Narrows, California Earthquake of October 1, 1987—Performance of Buildings at California State University, Los Angeles." Earthquake Spectra 4, no. 2 (May 1988): 277–317. http://dx.doi.org/10.1193/1.1585476.

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The Whittier Narrows earthquake (Richter Magnitude 5.9), which struck Southern California in the morning of October 1, 1987, caused some $20.5 million damage to various engineered buildings at California State University, Los Angeles and the death of a student due to a falling precast concrete panel. Peak ground acceleration of 0.39 g and a building response of 0.48 g were recorded in one of the affected buildings. The damage was both structural (cracking of reinforced concrete beams, columns and shear walls) and non-structural (cracked plaster and partition walls, dislodged and broken ceiling tiles, lights and other fixtures, damage to the science, computer and mechanical equipment and to utilities). A fire broke out in one chemistry laboratory and toxic combinations of chemicals were created by the spills in another chemistry laboratory. Shaking from the earthquake also aggravated existing friable asbestos contamination, forcing closure of one and portions of other buildings.

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Hauptman, Jason S., Andrew Dadour, Taemin Oh, Christine B. Baca, Barbara G. Vickrey, Stefanie D. Vassar, Raman Sankar, Noriko Salamon, Harry V. Vinters, and Gary W. Mathern. "Sociodemographic changes over 25 years of pediatric epilepsy surgery at UCLA." Journal of Neurosurgery: Pediatrics 11, no. 3 (March 2013): 250–55. http://dx.doi.org/10.3171/2012.11.peds12359.

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Object Low income, government insurance, and minority status are associated with delayed treatment for neurosurgery patients. Less is known about the influence of referral location and how socioeconomic factors and referral patterns evolve over time. For pediatric epilepsy surgery patients at the University of California, Los Angeles (UCLA), this study determined how referral location and sociodemographic features have evolved over 25 years. Methods Children undergoing epilepsy neurosurgery at UCLA (453 patients) were classified by location of residence and compared with clinical epilepsy and sociodemographic factors. Results From 1986 to 2010, referrals from Southern California increased (+33%) and referrals from outside of California decreased (−19%). Over the same period, the number of patients with preferred provider organization (PPO) and health maintenance organization (HMO) insurance increased (+148% and +69%, respectively) and indemnity insurance decreased (−96%). Likewise, the number of Hispanics (+117%) and Asians (100%) increased and Caucasians/whites decreased (−24%). The number of insurance companies decreased from 52 carriers per 100 surgical patients in 1986–1990 to 19 per 100 in 2006–2010. Patients living in the Eastern US had a younger age at surgery (−46%), shorter intervals from seizure onset to referral for evaluation (−28%) and from presurgical evaluation to surgery (−61%) compared with patients from Southern California. The interval from seizure onset to evaluation was shorter (−33%) for patients from Los Angeles County compared with those living in non-California Western US states. Conclusions Referral locations evolved over 25 years at UCLA, with more cases coming from local regions; the percentage of minority patients also increased. The interval from seizures onset to surgery was shortest for patients living farthest from UCLA but still within the US. Geographic location and race/ethnicity was not associated with differences in becoming seizure free after epilepsy surgery in children.

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Cheng, Meiling, Andy Campbell, Hendrik Folkerts, Amelia Jones, and Xing Yan. "The Artist Is Absent, or The Birth of Seven Documented Performances by Yan Xing." TURBA 1, no. 2 (September 1, 2022): 14–38. http://dx.doi.org/10.3167/turba.2022.010204.

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This account about The Birth of Seven Documented Performances—a series of planned live artworks by Yan Xing—features an assemblage of texts by five authors: a curator (Andy Campbell), a critic (Meiling Cheng), three performers (Campbell, Cheng, and Hendrik Folkerts), an audience member (Amelia Jones), and the artist (Yan Xing). The first installment of Yan’s performance series took place via Zoom in the guise of a quasi-improvised panel discussion, which was billed as part of Live Artists Live III: Despair/Repair (2020), a festival cocurated by Andy Campbell and Patty Chang at the University of Southern California (USC) in Los Angeles.

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van Erven, Eugene. "When José Met Sally: Chicano Theatre in L.A. at Grassroots and Mainstream." New Theatre Quarterly 12, no. 48 (November 1996): 356–66. http://dx.doi.org/10.1017/s0266464x0001054x.

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Playscript development programmes have been a significant breeding ground for new American drama since the mid'sixties, and in 1986 the Chicano playwright and director José Cruz González started a playwright development workshop specifically for the Latino community. Here, Eugene van Erven provides a bipolar view of the current Latino theatre scene in southern California by documenting the tenth anniversary session of González' Hispanic Playwrights Project at South Coast Rep, and at the same takes a wider look at grassroots community theatre initiatives in the Chicano neighbourhoods of Los Angeles. Eugene van Erven teaches in the American Studies programme at Utrecht University. Author of The Playful Revolution (Indiana University Press, 1992) and Radical People's Theatre (Indiana UP, 1988), he also designs and produces intercultural theatre projects.

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STARR, JOANN, and BRUCE E. ZAWACKI. "Voices from the Silent World of Doctor and Patient." Cambridge Quarterly of Healthcare Ethics 8, no. 2 (April 1999): 129–38. http://dx.doi.org/10.1017/s0963180199802023.

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Joann Starr, a Roman Catholic nun, and Bruce Zawacki, a burn surgeon, met 22 years ago in the Los Angeles County, University of Southern California Burn Center in the roles of a patient and her physician struggling over issues of autonomy and informed consent. After recovery, she remained a nun and has become a patient advocate and doctoral candidate in bioethics. He remained a burn surgeon and has become a bioethics teacher and author. Although they live in distant locations, they maintain their friendship and frequently discuss their shared experience. Recently they met to reflect on the events, lessons, and meanings of their original encounter.

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Koirala, Samir, and Chien-Ping Ko. "Neuron-Glial Interactions. The Sixth Annual University of Southern California Neuroscience Symposium, Los Angeles, November 6, 1998." CNS Drug Reviews 4, no. 4 (December 1998): 380–83. http://dx.doi.org/10.1111/j.1527-3458.1998.tb00078.x.

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Shettar, Manoj, Ravichandra Karkal, Anil Kakunje, Rohan Dilip Mendonsa, and VV Mohan Chandran. "Facebook addiction and loneliness in the post-graduate students of a university in southern India." International Journal of Social Psychiatry 63, no. 4 (May 15, 2017): 325–29. http://dx.doi.org/10.1177/0020764017705895.

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Background: Facebook is a social networking site (SNS) for communication, entertainment and information exchange. Recent research has shown that excessive use of Facebook can result in addictive behavior in some individuals. Aim: To assess the patterns of Facebook use in post-graduate students of Yenepoya University and evaluate its association with loneliness. Methods: A cross-sectional study was done to evaluate 100 post-graduate students of Yenepoya University using Bergen Facebook Addiction Scale (BFAS) and University of California and Los Angeles (UCLA) loneliness scale version 3. Descriptive statistics were applied. Pearson’s bivariate correlation was done to see the relationship between severity of Facebook addiction and the experience of loneliness. Results: More than one-fourth (26%) of the study participants had Facebook addiction and 33% had a possibility of Facebook addiction. There was a significant positive correlation between severity of Facebook addiction and extent of experience of loneliness ( r = .239, p = .017). Conclusion: With the rapid growth of popularity and user-base of Facebook, a significant portion of the individuals are susceptible to develop addictive behaviors related to Facebook use. Loneliness is a factor which influences addiction to Facebook.

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Hammes Ganguly, Dianne M., Debra K. Schrader, and Amy S. Martinez. "Planning for and Working With Children With an Auditory Brainstem Implant: What Therapists Need to Know." Perspectives of the ASHA Special Interest Groups 4, no. 1 (February 26, 2019): 149–66. http://dx.doi.org/10.1044/2018_pers-sig9-2018-0002.

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IntroductionInvestigations of auditory brainstem implants (ABIs) in children started around 2012 in the United States. The team at the University of Southern California-Caruso Family Center for Childhood Communication began seeing children, implanted abroad, in 2006. ABIs are indicated for children who cannot benefit from cochlear implants (CIs). The habilitation and educational needs of children with ABIs versus CIs differ.PurposeThis document provides information professionals can use when implementing habilitation programs for children with ABIs.MethodThe University of Southern California-Caruso Family Center for Childhood Communication, as part of the Los Angeles Pediatric ABI team, is conducting an ABI safety and feasibility clinical trial. This article shares experiences from the viewpoint of a multidisciplinary team. The article provides background knowledge, an outcomes review, and considerations to guide ABI intervention.ResultsABIs and CIs differ in the acoustic information they provide. Outcome studies suggest progress is slow with ABIs but that children can develop some auditory or spoken language skills. The children require highly supportive learning experiences. Visual communication support remains important. The considerations outlined reflect the children's need for explicit instruction.ConclusionsWhen serving children with ABIs, therapists must apply their broad knowledge about working with children with hearing loss, tempering that knowledge, and recognizing that auditory access and progress differ with ABIs compared to CIs. Educational and program placement decisions may require unconventional thinking.

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Huey, C. G., K. M. Chan, E. T. Wong, J. M. Nelson, and M. Durand. "Los Angeles County-University of Southern California Medical Center clinical pathology case conference: extreme hypermagnesemia in a neonate." Clinical Chemistry 41, no. 4 (April 1, 1995): 615–18. http://dx.doi.org/10.1093/clinchem/41.4.615.

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Abstract A preterm male infant born at 33 weeks of gestation developed respiratory depression and apnea at approximately 20 h after birth. Laboratory tests indicated severe hypermagnesemia, acidosis, and hypercalcemia. Cord blood and maternal blood concentrations of magnesium were normal. The effects and possible causes of hypermagnesemia are reviewed. The infant recovered with treatment, although the etiology of his hypermagnesemia remains unknown.

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Yamashita, Dennis-Duke R., and James P. McAndrews. "Oral and Maxillofacial Surgery Program, University of Southern California School Of Dentistry, Los Angeles County/USC Medical Center." Journal of Oral and Maxillofacial Surgery 65, no. 9 (September 2007): 1679–80. http://dx.doi.org/10.1016/j.joms.2006.09.027.

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LIPSCOMB, K., K. GREGORY, and K. SHAW. "The outcome of macrosomic infants weighing at least 4500 grams: Los Angeles County + University of Southern California experience." Obstetrics & Gynecology 85, no. 4 (April 1995): 558–64. http://dx.doi.org/10.1016/0029-7844(95)00005-c.

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Zaleski, S. F., G. Watabayashi, C. Dong, C. H. Barker, A. MacFadyen, D. Righi, G. Kachook, and B. Zelenke. "Predicting Surface Oil Transport in California Using a High-Resolution Regional Ocean Modeling System (ROMS) and the National Oceanic and Atmospheric Administration's (NOAA's) Trajectory Analysis Planner (TAP)." International Oil Spill Conference Proceedings 2017, no. 1 (May 1, 2017): 2017309. http://dx.doi.org/10.7901/2169-3358-2017.1.000309.

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The Bureau of Ocean Energy Management (BOEM) and Bureau of Safety and Environmental Enforcement (BSEE) Pacific Region conduct oil spill risk analyses to determine potential impacts to environmental resources. Oil spill trajectory modeling is conducted to predict the movement and fate of spilled oil, if a spill occurred, from existing offshore oil and gas operations in southern California. To improve BOEM and BSEE Pacific Region's ability to conduct oil spill risk analyses for southern California, BOEM partnered with the University of California, Los Angeles (UCLA) to run a multi-year hind cast (re-analysis) of winds, waves, and currents along the coast of California. UCLA created a high-resolution (1 km) ROMS hind cast for the 10 year period 2004–2013 from Morro Bay, California to the border with Mexico. The project was conducted in three phases: (1) Surface winds were calculated at high horizontal and temporal resolution and validated using existing datasets; (2) A wave model was forced by the wind model results and validated through in situ measurements; and (3) The ocean model was run at high resolution and includes temperature, salinity, and currents; it assimilated in situ data and was forced by the hind cast atmospheric model results. BOEM is subsequently partnering with NOAA, to utilize the surface currents and winds from the ROMS hind cast analysis with NOAA's General NOAA Operational Modeling Environment (GNOME) to produce multiple trajectories for NOAA's TAP. Using realistic oil spill scenarios over a range of different regional oceanographic regimes (such as upwelling, relaxation, and eddy-driven flow), TAP will calculate the probabilities of oil contacting parcels of water and shoreline were any oil to spill from southern California oil platforms. This will enable analysts to understand where an oil spill may travel, how long it could take to get there, and the likelihood of spilled oil contacting their resource area. An online TAP viewer with the GNOME-generated data from this study will be publicly available along with the ROMS hind cast data for oil spill response planning along with other oceanographic modeling needs.

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Flora, Gurdip S., Tamara Modilevsky, Diana Antoniskis, and Peter F. Barnes. "Undiagnosed Tuberculosis in Patients with Human Immunodeficiency Virus Infection* *From the Department of Medicine, Los Angeles County-University of Southern California Medical Center, Los Angeles." Chest 98, no. 5 (November 1990): 1056–59. http://dx.doi.org/10.1378/chest.98.5.1056.

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Herrmann, Maximilian, and Eva Gutheil. "Simulation of the Air Quality in Southern California, USA in July and October of the Year 2018." Atmosphere 13, no. 4 (March 29, 2022): 548. http://dx.doi.org/10.3390/atmos13040548.

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A numerical investigation of the air quality in Southern California, USA in the year 2018 is presented using the Weather Research and Forecasting model coupled with Chemistry (WRF-Chem). In July, a heat wave occurred, and in October, Santa Ana conditions prevailed; these conditions and their impact on air quality are the scope of the present numerical study.The high spatial resolution in the simulation includes two nested domains of 1 km and 3 km, respectively. Local climate zones land use categories are combined with the complex urban model building effect parameterization coupled with the building energy model (BEP+BEM) and the detailed MOZCART-T1 chemical reaction mechanism, which is the MOZART-T1 mechanism for trace gases with GOCART aerosols. Thus, the model is suitable to compare simulation results to in situ and satellite measurements of O3, NO2, CH4, and CO. The meteorology is captured well by the model. Comparison of simulation results with observations shows a good agreement of NO2 and ozone, whereas CO mixing ratios are generally underestimated. This hints at missing emissions in the 2017 National Emissions Inventory (NEI) dataset. Both the heat wave and the Santa Ana winds increase the air pollution with gas-phase species in Los Angeles. In both cases, nighttime boundary layer heights are small, which causes emissions to reside near the ground. During Santa Ana winds, NOx removal on aerosols is reduced. Methane mixing ratios are modeled very well at most stations in Los Angeles, but predictions of low emissions near the University of California cause inaccuracies at that location. Modeled and observed PM2.5 agree well on low-pollution days, but high-pollution events are generally missed by the model. During the heat wave, both modeled and observed PM2.5 concentrations exceed the recommended NAAQS National Ambient Air Quality Standards value of 12.5 g/m3. The present modeling approach serves as a base for the study and prediction of special weather events and their impact on air pollution.

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Cohen, Paul B. "Peter Brook and the ‘Two Worlds’ of Theatre." New Theatre Quarterly 7, no. 26 (May 1991): 147–59. http://dx.doi.org/10.1017/s0266464x0000542x.

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The ‘two worlds’ of Peter Brook's theatre are its audience and its actors. According to Brook, the actors bring their ‘world of the imagination’ to meet with the audience's ‘world of the everyday’: but instead of the temporary suspension of belief in the ‘everyday world’ which a western audience has traditionally forced upon itself, Brook conceives the true theatrical experience as an interaction between the two modes of reality – those of the ‘imagination’ and the mundane. In the following article, Paul Cohen assesses the importance of this basic philosophy to Brook's productions since 1968, paying particular attention to the tour of Africa with The Conference of the Birds and the recent epic production of The Mahabharata, attempting to show that Brook's theory still directly informs the methodology and the performance orientation of his productions. Paul Cohen originally presented this paper as an MA dissertation for Vanderbilt University, and is currently on the Professional Writing Program of the University of Southern California in Los Angeles.

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Horowitz, Richard E., Wesley Naritoku, and Elizabeth A. Wagar. "Management Training for Pathology Residents." Archives of Pathology & Laboratory Medicine 128, no. 1 (January 1, 2004): 59–63. http://dx.doi.org/10.5858/2004-128-59-mtfpr.

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Abstract Context.—Success in the practice of pathology demands proficiency in management, but management training for pathology residents is generally inadequate, with little agreement on an appropriate curriculum or competency assessment. Most residency training programs do not have faculty members who are interested and have expertise in management and who are dedicated to and have time available for teaching. Objective.—To develop a didactic management training program for the residents from 6 separate pathology residency programs in Southern California, with a comprehensive curriculum taught by experts in each area without undue burden on any single training program. Methods.—Faculty from the University of California–Los Angeles and the University of Southern California reviewed the literature and the management needs of practicing pathologists and devised the curriculum. Pathologist and nonpathologist speakers were identified who were working in important management positions both regionally and nationally. Seminars were presented in alternate months during a 2-year period. Sessions were videotaped, and each session was evaluated by the attendees. Results.—The curriculum consisted of 12 major topics, and seminars were delivered by 15 presenters from 6 institutions. Attendance was highest for residents in postgraduate years 2 and 3. The overall evaluation scores were exceedingly high (4.66 of a possible 5.0), and residents reported a significant increase in subject knowledge. Videotaping of presentations provided flexibility for residents who were unable to attend the seminars. Conclusion.—This program was effective and could serve as a template for other pathology residency training programs to establish curriculum content and develop resident competency. Teaching responsibilities were less burdensome when spread among several programs and when supplemented by nonpathology faculty. Electronic and audiovisual support enhanced flexibility and access to the program.

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Spear, Suzanne E., Hui Xie, Daniel Hernandez, Tennie Khanlian, Joshua Carlos, Raul Figueroa-Valenzuela, Roxana G. Barba, Joshua J. G. Manlutac, and Steven F. Loy. "3 WINS Fitness: A pilot study of a park-based program for low-income communities." Journal of Kinesiology & Wellness 10 (September 21, 2021): 31–39. http://dx.doi.org/10.56980/jkw.v10i.89.

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Three-quarters of American adults do not meet recommended guidelines for physical activity. This article presents results from a pilot study of 3 WINS Fitness (“3 WINS”), a free, park-based program for adults that started in 2011 at California State University, Northridge. The program is operated by kinesiology student interns. The pilot study took place in one large park in Los Angeles and included three sessions per week for 10 weeks. Methods: The main outcome was change in BMI after the 10-week program. We collected pre-post data on 66 participants. Change in BMI was examined for the sample as a whole and by normal weight, overweight, and obese classifications. Results: We found a small but significant decrease in BMI at program completion; however, there appeared to be less improvement for participants who were obese. Acceptability of the program was high. Most participants (78.5%) attended 50% of sessions or more. Conclusions: 3 WINS is a promising health promotion program that has the potential to be sustainable and scalable. Implementation of 3 WINS at the site of this pilot study has remained active since 2011. The sustainability of 3 WINS is facilitated by integrating the program into university kinesiology programs, creating partnerships with local parks, and reducing reliance on external funding to implement the program. The program has been adopted by numerous parks throughout Southern California and several universities throughout California.

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Roesch, Claudia. "The Social Distance Scale, Emory S. Bogardus and Californian Interwar Migration Research Offside the Chicago School." Journal of Migration History 1, no. 2 (October 29, 2015): 200–214. http://dx.doi.org/10.1163/23519924-00102003.

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This paper investigates the Social Distance Scale as a method to measure the degree of resentment towards immigrant groups invented by the University of Southern California sociologist Emory S. Bogardus. It asks why it is the only theory emerging from the orbit of the Chicago School still in use today. First, it looks at how Bogardus’s research environment in Los Angeles differed from that of his mentor Robert E. Park in Chicago. Then, it examines how Bogardus’s involvement with the Methodist All Nations Foundation influenced his conceptualisation of social distance. Third, it asks how this approach differed methodologically from the Chicago School’s Assimilation Theory. It concludes that the reciprocal relationship between Bogardus’s research and his social involvement caused him to dissolve the scale from spatial and temporal settings and create a theory that became universally applicable.

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Shulman, Ira A., Sunita Saxena, and Lois Ramer. "Assessing Blood Administering Practices." Archives of Pathology & Laboratory Medicine 123, no. 7 (July 1, 1999): 595–98. http://dx.doi.org/10.5858/1999-123-0595-abap.

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Abstract The risk that a red blood cell unit will be associated with an ABO-incompatible transfusion is currently slightly greater than the aggregate risk of acquiring human immunodeficiency virus, human T-cell lymphotropic virus, hepatitis B virus, or hepatitis C virus by transfusion. Since the most common cause for ABO-incompatible transfusion is the failure of transfusionists to properly identify a patient or a blood component before a transfusion, transfusion services are encouraged to evaluate and monitor the processes of dispensing and administering blood. In addition, a proposal of the Health Care Financing Administration of the Department of Health and Human Services would require hospitals to use a data-driven quality assessment and performance improvement program that evaluates the dispensing and administering of blood and that ensures that each blood product and each intended recipient is positively identified before transfusion. The Los Angeles County+University of Southern California Medical Center assesses the blood dispensing and administering process as proposed by the Health Care Financing Administration. During the fourth quarter of 1997, 85 blood transfusions were assessed for compliance with the Los Angeles County+University of Southern California Medical Center policies and procedures: 55 transfusion episodes had no variance from institutional protocol and 30 had one or more variances. Of the transfusions with at least one variance, 16 had one or more variances involving the identification of the patient, the component, or the paperwork. The remaining 14 transfusions had one or more variances involving other criteria (nonidentification items). The most frequent variance was the failure to document vital signs during the first 15 minutes after a transfusion was started or after 50 mL of a component had been transfused. No variances in patient or blood component identification were noted in nursing units whose staff routinely performed self-assessment of blood administering practices. Based on these findings, a corrective action plan was implemented. Follow-up assessments (n = 63) were conducted after 3 months (during the second quarter of 1998). The compliance with the pretransfusion identification protocol improved from 81% to 95%. The most common reason for noncompliance continued to be a lack of checking vital signs. This report demonstrates the value of using a data-driven program that assesses blood administering practices.

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Curtis, Jacqueline W., Andrew Curtis, and Jeffrey S. Upperman. "Using a Geographic Information System (GIS) to Assess Pediatric Surge Potential After an Earthquake." Disaster Medicine and Public Health Preparedness 6, no. 2 (June 2012): 163–69. http://dx.doi.org/10.1001/dmp.2012.25.

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ABSTRACTGeographic information systems (GIS) and geospatial technology (GT) can help hospitals improve plans for postdisaster surge by assessing numbers of potential patients in a catchment area and providing estimates of special needs populations, such as pediatrics. In this study, census-derived variables are computed for blockgroups within a 3-mile radius from Children's Hospital Los Angeles (CHLA) and from Los Angeles County–University of Southern California (LAC–USC) Medical Center. Landslide and liquefaction zones are overlaid on US Census Bureau blockgroups. Units that intersect with the hazard zones are selected for computation of pediatric surge potential in case of an earthquake. In addition, cartographic visualization and cluster analysis are performed on the entire 3-mile study area to identify hot spots of socially vulnerable populations. The results suggest the need for locally specified vulnerability models for pediatric populations. GIS and GT have untapped potential to contribute local specificity to planning for surge potential after a disaster. Although this case focuses on an earthquake hazard, the methodology is appropriate for an all-hazards approach. With the advent of Google Earth, GIS output can now be easily shared with medical personnel for broader application and improvement in planning.(Disaster Med Public Health Preparedness. 2012;6:163–169)

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Gutiérrez García, Carlos, and Mikel Pérez Gutiérrez. "“La contribución del judo a la educación” de Jigoro Kano. Introducción, traducción y notas." Revista de Artes Marciales Asiáticas 3, no. 3 (July 19, 2012): 38. http://dx.doi.org/10.18002/rama.v3i3.375.

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This paper translates and comments Jigoro Kano’s (1860-1938) conference The Contribution of Judo to Education, which the founder of Kodokan Judo gave at the University of Southern California (Los Angeles) in 1932. Through its lecture not only we appreciate Kano’s conception on judo, but also some of his personality characteristics revealing the amplitude of his knowledge and a humanistic character based on rationality and cooperation between individuals and countries.

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Sánchez, George J. "Opening the Humanities to New Fields & New Voices." Daedalus 151, no. 3 (2022): 82–93. http://dx.doi.org/10.1162/daed_a_01930.

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Abstract This essay explores efforts to enact effective “public humanities” among humanities practitioners as the “public” in the United States is changing profoundly. In particular, it explores the creation of the Boyle Heights Museum in East Los Angeles as an attempt to bridge the gap in historical practice and outreach between an immigrant and Latino community with a team of faculty, doctoral, and undergraduate students from the University of Southern California. Building four historical exhibitions in the Boyle Heights community, this team is a reflection of the growing awareness of the need to establish new institutional practices in archiving and historical presentations that reach new immigrant communities. New PhD students are in search of approaches to historical training, publishing, and output that engage with these new publics. Our own survival in the humanities fields is increasingly dependent on reaching these publics and creating this diversity of the humanities.

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Coleman, Rich F., James F. Drake, Michael D. McAtee, and Leslie O. Belsma. "Anthropogenic Moisture Effects on WRF Summertime Surface Temperature and Mixing Ratio Forecast Skill In Southern California." Weather and Forecasting 25, no. 5 (October 1, 2010): 1522–35. http://dx.doi.org/10.1175/2010waf2222384.1.

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Abstract Mesoscale forecasts for the Los Angeles basin made with the fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5) exhibited a moderate to substantial warm temperature bias for extended periods in the summer months. A similar bias also was thought to exist in forecasts made using version 2.2 of the Weather Research and Forecasting Model (WRF v2.2). To address these biases, two sources of anthropogenic moisture were analyzed: commercial irrigation and outdoor domestic water use. These represent substantial amounts of equivalent precipitation that are not accounted for in normal WRF execution. This is especially true for the summer months when little or no precipitation occurs in the area. A method for estimating the temporal and spatial distributions of these two sources was developed and the resulting database was applied to model runs. The addition of these anthropogenic moisture sources is an important source of enthalpy, which results in significant cooling in WRF. However, in the course of the analysis it was determined that the biases in WRF were much smaller than had been thought. Also, despite producing significant cooling, the addition of anthropogenic moisture made only modest improvements in forecast skill, and only for some hours of the day, indicating that more research is necessary on how the physical processes are handled in WRF, and how the anthropogenic moisture is distributed during the forecast period.

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Zhang, Wu, Oliver A. Press, Christopher A. Haiman, Dong Yun Yang, Michael A. Gordon, William Fazzone, Anthony El-khoueiry, et al. "Association of Methylenetetrahydrofolate Reductase Gene Polymorphisms and Sex-Specific Survival in Patients With Metastatic Colon Cancer." Journal of Clinical Oncology 25, no. 24 (August 20, 2007): 3726–31. http://dx.doi.org/10.1200/jco.2007.11.4710.

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Purpose Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating intracellular folate levels, which affects DNA synthesis and methylation. Two MTHFR gene polymorphisms, C677T and A1298C, are linked to altered enzyme activity. Several studies have shown these two polymorphisms to be associated with response to fluorouracil (FU) -based treatment in advanced colon cancer patients, but data are inconsistent and contradictory. Meanwhile, epidemiologic studies demonstrated that these MTHFR polymorphisms were associated with cancer risk in a sex-specific manner. We tested the hypothesis of whether these two polymorphisms are associated with sex-specific clinical outcome in metastatic colon cancer patients treated with FU-based chemotherapy. Patients and Methods This study included 318 patients (177 men and 141 women) with metastatic colon cancer treated between 1992 and 2003 at the University of Southern California/Norris Comprehensive Cancer Center or Los Angeles County/University of Southern California Medical Center. Peripheral blood samples were collected from each patient, and genomic DNA was extracted from WBCs. Two MTHFR gene polymorphisms (C677T and A1298C) were tested by fluorogenic 5′-nuclease assay. Results The A1298C polymorphism showed statistically significant differences in overall survival (OS) in female, but not male, patients with metastatic colon cancer (log-rank test, P = .038). Among females, OS was greater for patients with the A/A genotype (n = 67; median OS, 18.4 months) compared with patients with the A/C genotype (n = 50; median OS, 13.9 months) or C/C genotype (n = 10; median OS, 15.6 months). Conclusion Although preliminary, these data support the role of the A1298C polymorphism in MTHFR as prognostic marker in female patients with metastatic colon cancer. Further studies are needed to confirm these findings.

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Gardner, Daniel, Andrew Liman, Victoria Autelli, Casey O'Connell, Nicholas Testa, and Glenn Ault. "Initiating a Standard Venous Thromboembolism Prophylaxis Order Set Designed to Improve Patient Outcomes at Los Angeles County + University of Southern California." American Surgeon 82, no. 10 (October 2016): 1000–1004. http://dx.doi.org/10.1177/000313481608201032.

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Improving patient safety is vital for all hospitals due to increasing public reporting and pay-for-performance reimbursement. Venous thromboembolism (VTE) remains a leading cause of preventable mortality accounting for 5 per cent of inpatient deaths. The purpose of this study was to outline the process of implementing standard VTE prophylactic order sets in a 600-bed academic safety net hospital and assess the resulting change in patient outcomes. Outcomes were assessed by comparing the rate that eligible inpatients receive VTE prophylaxis and the rate of preventable VTE's compared with total VTE's. From 2011 to 2015, random samples of 60 Los Angeles County+University of Southern California inpatients were generated monthly to examine compliance rates by comparing ICD-9 diagnostic codes to ordered VTE prophylaxis. All inpatient VTE's are retrospectively analyzed. Baseline-ordered VTE prophylaxis was 37 per cent in 2010. The target of 85 per cent was exceeded by the second quarter of 2012 to 2013 when compliance reached 88 per cent, a 51 per cent increase from baseline ( P < 0.01). These results suggest VTE protocols are effective though standardization across service lines is often difficult. Despite these challenges, after implementing standard order sets, we saw compliance increase significantly. Ongoing analysis to determine whether VTE rates have significantly decreased is presently underway.

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Brown, Kristine, and James Sturges. "Community Outreach Partnership Center (COPC)." Californian Journal of Health Promotion 1, no. 2 (June 1, 2003): 44–51. http://dx.doi.org/10.32398/cjhp.v1i2.1681.

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With the continued influx of Mexican immigrants to the United States, especially to Southern California, health concerns and needs have increased among this population over the last several years. California State Polytechnic University, Pomona (Cal Poly Pomona) obtained a federal grant that provided resources to establish the Community Outreach Partnership Center (COPC). COPC consists of comprehensive efforts to improve the overall well-being of the Angela Chanslor area within the City of Pomona in East Los Angeles. Focus areas of the project include 1) Education and Integrated Services, 2) Community Planning and Capacity Building for Neighborhood Revitalization and Safety, and 3) Job Development and Training. The focus of this paper is health promotion activities within Education and Integrated Services. The primary objective of this portion of the program was to provide residents with physical examinations and health screenings, health education, and medical and social service referrals. Topics discussed are the target community, general overview of COPC, Family Services Information and Referral Program (i.e. health promotion program within Education and Integrated Services), program impact and results, and suggestions for continued implementation and future efforts. / Con la influencia continua de inmigrantes Mexicanos a los Estados Unidos, especialmente al sur de California, ciertas necesidades con respecto a la salud han incrementado en esta poblacion en los ultimos anos. California State Polytechnic University, Pomona (Cal Poly Pomona). Obtuvo ayuda Federal para establecer El Community Outreach Partnership Center (COPC). El centro COPC consiste de esfuerzos conprensivos para mejorar el bienestar del area Angela Chanslor que esta ubicado en la Ciudad de Pomona en la parte Este de Los Angeles. Las partes enfocadas del proyecto incluyen, 1) Educacion y servicios Integrados, 2) Plan para la Comunidad y un Edificio de Capacitacion para la comunidad que dara revitalizacion y seguridad, 3) Y habrira trabajos y entrenamientos. El enfoque de este proyecto es de actividades en Promocion de Salud aliadas con educacion y Servicios Integrados. El objetivo principal de esta porcion del programa era de proveer a los residentes con examinaciones fisicas, educacion para la salud, y eran referidas a servicios medicos y sociales. Los topicos que son tratados son: La comunidad que sera ayudada, El enfoque general de COPC, informacion del programa para referir a servicios familiares, el impacto del programa y resultados, y sugerencias para implementar futuros esfuerzos.

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Brown, Kristine, and James Sturges. "Community Outreach Partnership Center (COPC)." Californian Journal of Health Promotion 1, no. 2 (June 1, 2003): 44–51. http://dx.doi.org/10.32398/cjhp.v1i2.426.

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With the continued influx of Mexican immigrants to the United States, especially to Southern California, health concerns and needs have increased among this population over the last several years. California State Polytechnic University, Pomona (Cal Poly Pomona) obtained a federal grant that provided resources to establish the Community Outreach Partnership Center (COPC). COPC consists of comprehensive efforts to improve the overall well-being of the Angela Chanslor area within the City of Pomona in East Los Angeles. Focus areas of the project include 1) Education and Integrated Services, 2) Community Planning and Capacity Building for Neighborhood Revitalization and Safety, and 3) Job Development and Training. The focus of this paper is health promotion activities within Education and Integrated Services. The primary objective of this portion of the program was to provide residents with physical examinations and health screenings, health education, and medical and social service referrals. Topics discussed are the target community, general overview of COPC, Family Services Information and Referral Program (i.e. health promotion program within Education and Integrated Services), program impact and results, and suggestions for continued implementation and future efforts. / Con la influencia continua de inmigrantes Mexicanos a los Estados Unidos, especialmente al sur de California, ciertas necesidades con respecto a la salud han incrementado en esta poblacion en los ultimos anos. California State Polytechnic University, Pomona (Cal Poly Pomona). Obtuvo ayuda Federal para establecer El Community Outreach Partnership Center (COPC). El centro COPC consiste de esfuerzos conprensivos para mejorar el bienestar del area Angela Chanslor que esta ubicado en la Ciudad de Pomona en la parte Este de Los Angeles. Las partes enfocadas del proyecto incluyen, 1) Educacion y servicios Integrados, 2) Plan para la Comunidad y un Edificio de Capacitacion para la comunidad que dara revitalizacion y seguridad, 3) Y habrira trabajos y entrenamientos. El enfoque de este proyecto es de actividades en Promocion de Salud aliadas con educacion y Servicios Integrados. El objetivo principal de esta porcion del programa era de proveer a los residentes con examinaciones fisicas, educacion para la salud, y eran referidas a servicios medicos y sociales. Los topicos que son tratados son: La comunidad que sera ayudada, El enfoque general de COPC, informacion del programa para referir a servicios familiares, el impacto del programa y resultados, y sugerencias para implementar futuros esfuerzos.

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Czelusniak, Patrícia, Talissa Gabrielle Ritter Walczak, and Thelma L. Skare. "Shoulder pain and dysfunction in 150 type 2 diabetes mellitus patients." Arquivos Brasileiros de Endocrinologia & Metabologia 56, no. 4 (June 2012): 233–37. http://dx.doi.org/10.1590/s0004-27302012000400003.

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OBJECTIVE: To study the prevalence of shoulder pain and dysfunction in patients from Southern Brazil with diabetes mellitus (DM) and to evaluate the association of pain and dysfunction with diabetes control and epidemiological factors. SUBJECTS AND METHODS: We studied 150 patients with type 2 DM for pain and shoulder dysfunction with the UCLA-m (modified University of California at Los Angeles Shoulder Rating Scale); for epidemiological and treatment data, values of Hb A1C and plasma glucose were analyzed. RESULTS: Pain was present in 63.4%, and dysfunction in 53.4% of the studied sample; 26.6% of the patients rated shoulder performance as bad. No association was found between Hb A1C or plasma glucose and joint function, except for active flexion of the shoulder and fasting glucose (p = 0.026). Women had worse shoulder performance (p = 0.0043), as did elderly patients (p < 0.0001). CONCLUSIONS: Shoulder pain and dysfunction is highly prevalent in patients with type 2 diabetes; these disorders affect more women and the elderly.

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Lincoln, Karen. "Advocates for African American Elders: Engaging Older Adults in Education and Research." Innovation in Aging 4, Supplement_1 (December 1, 2020): 844–45. http://dx.doi.org/10.1093/geroni/igaa057.3097.

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Abstract Advocates for African American Elders (AAAE) is an outreach and engagement program at the University of Southern California, providing culturally competent health education for older African Americans throughout Los Angeles County (LAC). Founded in 2012 to address racial disparities in health outcomes, AAAE partners with community-based agencies, government, and health plans to address the persistent growing needs of older African Americans. AAAE educates and disseminates information about healthcare policies and resources through fact sheets, educational forums, and the AAAE website. It collaborates with local healthcare providers to improve outreach, education, and care, and assesses service needs and resources via surveys in LAC. The program engages in community-based participatory research to provide real-world solutions for improving health outcomes and build community research capacity. This presentation will highlight AAAE’s community-based approach to raising awareness, increasing knowledge and access to healthcare resources, and improving health outcomes for older African Americans and their families.

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Harley, James. "Addendum." Tempo, no. 212 (April 2000): 54. http://dx.doi.org/10.1017/s0040298200007671.

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I am writing to provide further information in response to inquiries about my recent article on performance issues in Gorecki's music (Tempo 211). The symposium I referred to, at which the composer was present, was titled ‘The Gorecki Phenomenon’, and, in addition to my own, included presentations by Adrian Thomas, Luke Howard, David Kopplin, Mark Swed, and Maria Anna Harley, who organized and chaired the event (and translated the commentaries of Mr Gorecki, who had much to say). This session, along with entire ‘Gorecki Autumn’ at the University of Southern California, was organized to celebrate the endowement of the Directorship of the Polish Music Reference Center by Dr Stefan and Mrs Wanda Wilk, founders of this important resource on Polish music in North America (the website can be consulted at http://www.usc.edu/dept/polishmusic/). A book collecting the research presented at this symposium, along with the lectures and interviews given by the composer during his time in Los Angeles, is forthcoming, edited by Ms Harley.

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Idos, Gregory E., Allison W. Kurian, Charité Ricker, Duveen Sturgeon, Julie O. Culver, Kerry E. Kingham, Rachel Koff, et al. "Multicenter Prospective Cohort Study of the Diagnostic Yield and Patient Experience of Multiplex Gene Panel Testing For Hereditary Cancer Risk." JCO Precision Oncology, no. 3 (December 2019): 1–12. http://dx.doi.org/10.1200/po.18.00217.

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Purpose Multiplex gene panel testing (MGPT) allows for the simultaneous analysis of germline cancer susceptibility genes. This study describes the diagnostic yield and patient experiences of MGPT in diverse populations. Patients and Methods This multicenter, prospective cohort study enrolled participants from three cancer genetics clinics—University of Southern California Norris Comprehensive Cancer Center, Los Angeles County and University of Southern California Medical Center, and Stanford Cancer Institute—who met testing guidelines or had a 2.5% or greater probability of a pathogenic variant (N = 2,000). All patients underwent 25- or 28-gene MGPT and results were compared with differential genetic diagnoses generated by pretest expert clinical assessment. Post-test surveys on distress, uncertainty, and positive experiences were administered at 3 months (69% response rate) and 1 year (57% response rate). Results Of 2,000 participants, 81% were female, 41% were Hispanic, 26% were Spanish speaking only, and 30% completed high school or less education. A total of 242 participants (12%) carried one or more pathogenic variant (positive), 689 (34%) carried one or more variant of uncertain significance (VUS), and 1,069 (53%) carried no pathogenic variants or VUS (negative). More than one third of pathogenic variants (34%) were not included in the differential diagnosis. After testing, few patients (4%) had prophylactic surgery, most (92%) never regretted testing, and most (80%) wanted to know all results, even those of uncertain significance. Positive patients were twice as likely as negative/VUS patients (83% v 41%; P < .001) to encourage their relatives to be tested. Conclusion In a racially/ethnically and socioeconomically diverse cohort, MGPT increased diagnostic yield. More than one third of identified pathogenic variants were not clinically anticipated. Patient regret and prophylactic surgery use were low, and patients appropriately encouraged relatives to be tested for clinically relevant results.

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Chehrazi-Raffle, Alex, Nicholas Salgia, Joann Hsu, Zeynep Busra Zengin, Sabrina Salgia, Neal Chawla, Jasnoor Malhotra, et al. "Bridging the gaps between tertiary and community care networks: Results from a southern California survey research analysis." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 1538. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1538.

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1538 Background: Although many tertiary cancer centers offer access to myriad research protocols, the majority of patients nevertheless receive treatment at community practices. We sought to examine the barriers that hamper clinical collaboration between tertiary and community practice environments in Southern California. Methods: A 31-item survey was distributed to community and tertiary oncologists using REDCap, a browser-based electronic data capture system. Survey questions assessed the following attributes: demographics and features of clinical practice, referral patterns, availability and knowledge pertaining to clinical trials, strategies for knowledge acquisition, and integration of community and tertiary practices. Results: The survey was distributed to 98 oncologists, 85 (87%) of whom completed it in full. The most common institutional affiliations were City of Hope Comprehensive Cancer Center (58%), University of California, Los Angeles (10%), and Cedars Sinai Medical Center (8%). In total, 52 (61%) respondents were community practitioners and 33 (38%) were tertiary oncologists. A majority (56%) of community oncologists defined themselves as general oncologists whereas almost all (97%) tertiary oncologists reported a subspecialty. Clinical trial availability was the most common reason for pt referrals to tertiary centers (73%). The most frequent barrier to tertiary referral was financial considerations (59%). Clinical trials were offered by 97% of tertiary practitioners as compared to 67% of community oncologists (p = 0.001). Of note, while a majority of tertiary center providers (52%) described the primary value of community practices to be a source of referrals for clinical trials, most community oncologists (82%) reported only a minimal-to-moderate understanding of clinical trials available at regional tertiary centers. Conclusions: Community oncologists refer patients to tertiary centers primarily with the intent of clinical trial enrollment; however, significant gaps exist in their knowledge of trial availability. Our results identify the need for enhanced communication and collaboration between community and tertiary providers to expand patients’ access to clinical trials.

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Berry, Jesse L., Grace Shih, Stavros N. Moysidis, Rima Jubran, Kenneth Wong, Thomas C. Lee, A. Linn Murphree, and Jonathan W. Kim. "Patterns of subretinal fluid resolution in Group D eyes treated with chemoreduction: Experience from the Children’s Hospital Los Angeles/University of Southern California." Ophthalmic Genetics 37, no. 4 (March 2, 2016): 400–403. http://dx.doi.org/10.3109/13816810.2015.1115881.

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Appleman, M. D., P. N. R. Heseltine, and C. E. Cherubin. "Epidemiology, Antimicrobial Susceptibility, Pathogenicity, and Significance of Bacteroides fragilis Group Organis,s Isolated at Los Angeles County-University of Southern California Medical Center." Clinical Infectious Diseases 13, no. 1 (January 1990): 12–18. http://dx.doi.org/10.1093/clinids/13.1.12.

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In, Gino Kim, Dongyun Yang, Jacob Stephen Thomas, Anthony Pham, Arnab Basu, Arjun Ajay Mehta, Kimberly Ann Miller, Myles Cockburn, and James Hu. "Frequency and outcomes of melanoma subtypes in a diverse population: The Los Angeles County – University of Southern California (LAC-USC) Medical Center experience." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e21063-e21063. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e21063.

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e21063 Background: Melanoma is a biologically heterogeneous disease that varies by ethnicity and histology. While superficial spreading (SSM) histology is the most common subtype in non-Hispanic whites (NHW), acral lentiginous (ALM) and other subtypes occur more frequently in Hispanics, Asians and African Americans. There are no known risk factors for ALM, and further investigation is warranted. Methods: We retrospectively reviewed a database of melanoma patients diagnosed between 2001-2016 at LAC-USC. Overall survival (OS) was estimated using Kaplan-Meier methodology, and comparisons performed using log-rank testing. Fisher’s exact test was used to evaluate associations between relevant clinicopathological variables. A p-value < 0.05 was considered statistically significant. Results: Among 272 melanoma patients, there were 140 Hispanics (51.5%), 105 NHW (38.6%), 14 Asians, and 4 African Americans. The most frequent histology among Hispanics was ALM (30.7%), while SSM was the most frequent among NHW (33.3%). BRAF V600 mutations were found in 34.5% (10/29) and 58.8% (10/17) of Hispanics and NHW, respectively. A total of 52 patients with ALM were identified, including 43 Hispanics (82.7%). There was a significant association between no prior history of non-melanoma skin cancer (NMSC) and ALM (p < .0001). Median Breslow thickness for ALM was 4.2 mm, and 32.7% were ulcerated. The rate of BRAF V600 mutations among 13 ALM patients tested was 0%. NRAS mutations were found in 3 ALM patients; KIT amplification/mutations were found in 2 ALM patients. Conclusions: We identified a population enriched for Hispanic patients with ALM. We found an association between no prior NMSC and ALM, suggesting that UV exposure is not a causative risk factor. BRAF mutations are less common amongst Hispanics, and nearly absent in ALM. Survival differences were not statistically significant, but cannot be ruled out due to low number of patients in this early study. [Table: see text]

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GREULICH, B., L. PAINE, C. MCCLAIN, M. BARGER, N. EDWARDS, and R. PAUL. "Twelve years and more than 30,000 nurse-midwife-attended births: The Los Angeles County + University of Southern California Women's Hospital birth center experience." Journal of Nurse-Midwifery 39, no. 4 (July 1994): 185–96. http://dx.doi.org/10.1016/0091-2182(94)90025-6.

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Press, O. A., W. Zhang, D. Yang, C. A. Haiman, M. Gordon, A. M. Schultheis, F. Nagashima, A. Sherrod, S. Iqbal, and H. Lenz. "Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms associated with overall survival in women with metastatic colon cancer." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 3600. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.3600.

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3600 Background: Methylenetetrahydrofolate Reductase (MTHFR) is a key enzyme regulating intracellular folate pool, which affects DNA synthesis and methylation. Recent studies found folate deficiency induces DNA damage because of impaired nucleotide-excision repairs in mouse model. Two MTHFR gene polymorphisms, C677T and A1298C are linked to altered enzyme activity. Numerous studies have shown these two polymorphisms associated with colon cancer risk and response to fluorouracil-based treatment in advanced colon cancer patients. One epidemiology study also demonstrated 1298CC genotype to be associated with a significantly lower risk of colon cancer in women, but not men. We tested whether these two polymorphisms were associated with clinical outcome in metastatic colon cancer patients treated with 5-FU/Oxaliplatin. Methods: Between 1992 and 2003, a total of 318 patients with metastatic colon cancer treated at the University of Southern California/Norris Comprehensive Cancer Center (USC/NCCC) or the Los Angeles County/University of Southern California Medical Center (LAC/USCMC), were eligible for this study. Peripheral blood samples were collected from each patient and genomic DNA was extracted from white blood cells using the QiaAmp kit (Qiagen, Valencia, CA). Two MTHFR gene polymorphisms (C677T, A1298C) were tested by PCR-RFLP method. Results: MTHFR A1298C gene polymorphism showed statistically significant differences in overall survival (OS) in female patients with metastatic colon cancer (P=0.025, logrank test). Patients with the AA genotype had an 18.7 months median OS compared with the heterozygous AC genotype, which had a 14.3 months median OS and the CC genotype, which had a 15.9 months median OS. Conclusions: There is no significant difference in clinical outcome in male patients. However, female metastatic colon cancer patients with a MTHFR A1298C polymorphism AA genotype have significantly better overall survival than those with heterozygous AC genotype or CC genotype. This data supports the role of MTHFR polymorphisms as an independent prognostic marker in female patients with metastatic colon cancer. Further prospective study is needed to confirm these preliminary findings. [Table: see text]

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Journal articles on the topic 'University of Southern California Los Angeles'

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