Academic literature on the topic 'Unnatural amino acids'

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Journal articles on the topic "Unnatural amino acids"

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Magliery, Thomas. "Unnatural Protein Engineering: Producing Proteins with Unnatural Amino Acids." Medicinal Chemistry Reviews - Online 2, no. 4 (2005): 303–23. http://dx.doi.org/10.2174/1567203054637542.

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Archer, I., I. Fotheringham, R. Carr, R. Speight, and N. J. Turner. "Preparative deracemization of unnatural amino acids." Biochemical Society Transactions 34, no. 2 (2006): 287. http://dx.doi.org/10.1042/bst20060287.

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Hausmann, Corinne D., Jiqiang Ling, and Michael Ibba. "The unnatural culture of amino acids." Nature Methods 4, no. 3 (2007): 205–6. http://dx.doi.org/10.1038/nmeth0307-205.

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Fotheringham, I., I. Archer, R. Carr, R. Speight, and N. J. Turner. "Preparative deracemization of unnatural amino acids." Biochemical Society Transactions 34, no. 2 (2006): 287–90. http://dx.doi.org/10.1042/bst0340287.

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Unnatural amino acids are a growing class of intermediates required for pharmaceuticals, agrochemicals and other industrial products. However, no single method has proven sufficiently versatile to prepare these compounds broadly at scale. To address this need, we have developed a general chemoenzymatic process to prepare enantiomerically pure L- and D-amino acids in high yield by deracemization of racemic starting materials. This method involves the concerted action of an enantioselective oxidase biocatalyst and a non-selective chemical reducing agent to effect the stereoinversion of one enant
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Kigawa, Takanori, Shigeyuki Yokoyama, and Tatsuo Miyazawa. "Incorporation of unnatural amino acids proteins." Kobunshi 39, no. 7 (1990): 500–503. http://dx.doi.org/10.1295/kobunshi.39.500.

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Bilgiçer, Basar, and Krishna Kumar. "Protein Design Using Unnatural Amino Acids." Journal of Chemical Education 80, no. 11 (2003): 1275. http://dx.doi.org/10.1021/ed080p1275.

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Hallam, Trevor J., Erik Wold, Alan Wahl, and Vaughn V. Smider. "Antibody Conjugates with Unnatural Amino Acids." Molecular Pharmaceutics 12, no. 6 (2015): 1848–62. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00082.

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Zhang, William H., Gottfried Otting, and Colin J. Jackson. "Protein engineering with unnatural amino acids." Current Opinion in Structural Biology 23, no. 4 (2013): 581–87. http://dx.doi.org/10.1016/j.sbi.2013.06.009.

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Nödling, Alexander R., Luke A. Spear, Thomas L. Williams, Louis Y. P. Luk, and Yu-Hsuan Tsai. "Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells." Essays in Biochemistry 63, no. 2 (2019): 237–66. http://dx.doi.org/10.1042/ebc20180042.

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Abstract Genetic code expansion allows unnatural (non-canonical) amino acid incorporation into proteins of interest by repurposing the cellular translation machinery. The development of this technique has enabled site-specific incorporation of many structurally and chemically diverse amino acids, facilitating a plethora of applications, including protein imaging, engineering, mechanistic and structural investigations, and functional regulation. Particularly, genetic code expansion provides great tools to study mammalian proteins, of which dysregulations often have important implications in hea
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Adhikari, Anup, Bibek Raj Bhattarai, Ashika Aryal, et al. "Reprogramming natural proteins using unnatural amino acids." RSC Advances 11, no. 60 (2021): 38126–45. http://dx.doi.org/10.1039/d1ra07028b.

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Dissertations / Theses on the topic "Unnatural amino acids"

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Reeve, P. "Functionalising unnatural amino acids." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19650/.

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Middleton, Richard John. "Synthesis of unnatural [alpha] - amino acids." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338866.

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Fryer, Andrew Mark. "Syntheses of natural and unnatural kainoid amino acids." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393580.

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Reddington, Samuel C. "Introducing novel protein functionality using unnatural amino acids." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/56226/.

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This thesis examines the tolerance and effects of unnatural amino acid (Uaa) incorporation into proteins in Escherichia coli using an expanded genetic code. Uaa incorporation was used to alter or install new properties in the target proteins, superfolder Green Fluorescent Protein (sfGFP) and cytochrome b562. Chapter 3 deals with the technical aspects of Uaa incorporation including orthogonality of the machinery and yield. Substitution of residues in sfGFP for unnatural analogues of tyrosine was shown to be a valuable way of altering the properties of the protein. Variants were generated with r
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Rodriguez, Erik Ali Tirrell David A. Dougherty Dennis A. "In Vivo Incorporation of Multiple Unnatural Amino Acids /." Diss., Pasadena, Calif. : California Institute of Technology, 2009. http://resolver.caltech.edu/CaltechETD:etd-01122009-153110.

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Bilgiçer, Zihni Basar. "Protein design using unnatural amino acids with fluorinated side chains /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2005.

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Thesis (Ph.D.)--Tufts University, 2005.<br>Adviser: Krishna Kumar. Submitted to the Dept. of Chemistry. Includes bibliographical references. Access restricted to members of the Tufts University community. Also available via the World Wide Web;
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Valancogne, Ingrid. "Synthesis of unnatural amino acids and dipeptides for potential catalysts." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300361.

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Wang, Jinfan. "In Vitro Kinetics of Ribosomal Incorporation of Unnatural Amino Acids." Doctoral thesis, Uppsala universitet, Struktur- och molekylärbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282023.

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Ribosomal incorporation of unnatural amino acids (AAs) into peptides or proteins has found broad applications in studying translation mechanism, discovering potential therapeutics, and probing protein structure and function. However, such applications are generally limited by the low incorporation efficiencies of the unnatural AAs. With in vitro kinetics studies using a purified E. coli translation system, we found that the natural N-alkyl AA carrier, tRNAPro, could hasten the incorporation of N-methyl AAs. Also, the incorporation rate increased remarkably with increasing pH in the range of 7
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Bhushan, Bhaskar. "Unnatural amino acids as metal-mediated probes of biological function." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4b1cbed6-1151-4b9f-ad97-aa5765cc9384.

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Conjugation reactions on proteins have been used to access various post-translational modifications, for targeted delivery of drugs, for microscopy, and in studying receptor-ligand interactions. However, the ability to modify native proteins is constrained by the reactive functionalities of naturally occurring amino acids. This has driven research into the incorporation of unnatural amino acids (UAAs) into proteins. Research in this area has been motivated both by the possibility of increasing the breadth of chemical techniques for protein modification by introducing novel 'bio-orthogonal' rea
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Drummond, Lorna J. "New methodology for the stereoselective synthesis of unnatural alpha-amino acids." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2827/.

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New general methodology for the stereoselective synthesis of unnatural alpha-amino acids has been developed. Early work focussed on investigating methods for the generation of chiral allylic alcohols using cross-metathesis of a simple enone with various terminal alkenes, followed by an asymmetric ketone reduction. The allylic alcohols were then converted to protected allylic amines via Overman rearrangement chemistry. Oxidative alkene cleavage and hydrolysis of these intermediates generated a range of alpha-amino acid targets. Attempts were also made to apply the developed methodology to the s
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Books on the topic "Unnatural amino acids"

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Pollegioni, Loredano, and Stefano Servi, eds. Unnatural Amino Acids. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-331-8.

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Pollegioni, Loredano, and Stefano Servi. Unnatural Amino Acids: Methods and Protocols. Humana Press, 2016.

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Unnatural amino acids: Methods and protocols. Humana Press, 2012.

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Bag, Subhendu Sekhar, Ishu Saraogi, and Jiantao Guo, eds. Expansion of the Genetic Code: Unnatural Amino Acids and Their Applications. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88976-843-1.

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Unnatural Amino Acid Incorporation and Click Chemistry. GRIN Verlag GmbH, 2018.

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Book chapters on the topic "Unnatural amino acids"

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Yu, Yang, Xiaohong Liu, and Jiangyun Wang. "Protein Engineering Using Unnatural Amino Acids." In Protein Engineering. WILEY-VCH GmbH, 2021. http://dx.doi.org/10.1002/9783527815128.ch10.

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Ager, David J. "Synthesis of Unnatural/Nonproteinogenic α-Amino Acids." In Amino Acids, Peptides and Proteins in Organic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527631766.ch12.

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D’Arrigo, Paola, and Davide Tessaro. "Multistep Enzyme Catalyzed Reactions for Unnatural Amino Acids." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-331-8_2.

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Furuta, Takumi. "Biaryl Amino Acids and Their Surrogates: A Unique Class of Unnatural Amino Acid." In Designed Molecular Space in Material Science and Catalysis. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1256-4_6.

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Castiglione, Franca. "NMR Analysis of Unnatural Amino Acids in Natural Antibiotics." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-331-8_7.

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Lang, Kathrin, Lloyd Davis, and Jason W. Chin. "Genetic Encoding of Unnatural Amino Acids for Labeling Proteins." In Site-Specific Protein Labeling. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2272-7_15.

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Hansen, William A., Jeremy H. Mills, and Sagar D. Khare. "Computational Design of Multinuclear Metalloproteins Using Unnatural Amino Acids." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3569-7_10.

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Davis, Lloyd, and Sebastian Greiss. "Genetic Encoding of Unnatural Amino Acids in C. elegans." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7574-7_24.

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Helma, Jonas, Heinrich Leonhardt, Christian P. R. Hackenberger, and Dominik Schumacher. "Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7574-7_4.

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Imperiali, B., R. Sinha Roy, G. K. Walkup, and L. Wang. "Unnatural Amino Acids for the Design of Functional Proteins: Biomimetic Catalysis Using Coenzyme-Amino Acids." In Molecular Design and Bioorganic Catalysis. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-1679-1_3.

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Conference papers on the topic "Unnatural amino acids"

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Silva, Maísa de Carvalho, Lariza Laura De Oliveira, and Renato Tinós. "Optimization of Expanded Genetic Codes via Genetic Algorithms." In XV Encontro Nacional de Inteligência Artificial e Computacional. Sociedade Brasileira de Computação - SBC, 2018. http://dx.doi.org/10.5753/eniac.2018.4440.

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In the last decades, researchers have proposed the use of genetically modified organisms that utilize unnatural amino acids, i.e., amino acids other than the 20 amino acids encoded in the standard genetic code. Unnatural amino acids have been incorporated into genetically engineered organisms for the development of new drugs, fuels and chemicals. When new amino acids are incorporated, it is necessary to modify the standard genetic code. Expanded genetic codes have been created without considering the robustness of the code. The objective of this work is the use of genetic algorithms (GAs) for
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Katti, Kalpana S., Dinesh R. Katti, and Avinash H. Ambre. "Unnatural Amino Acids Modified Clays for Design of Scaffolds for Bone Tissue Engineering." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13242.

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Here, we incorporate the results of our new “altered phase theory” (Sikdar et al. 2008a) into design of new polymer clay nanocomposites (PCNs) for bone biomaterials applications. Montmorillonite (MMT) clay was modified using unnatural amino acids as potentially new biocompatible modifiers. The longer carbon chain structures of the unnatural amino acids are expected to enhance non bonded interactions with clay as well as maintaining the usefulness of functional groups of natural amino acids. The specific choice of amino acids is based on both the antibacterial activity reported in literature an
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Vrabel, Milan, Emine Kaya, and Thomas Carell. "Incorporation of unnatural amino acids into proteins for click chemistry." In XVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112487.

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Pajpanova, Tamara. "Design, synthesis, analysis and pharmacological evaluation of neuropeptide mimetics containing unnatural amino acids." In XIth Conference Biologically Active Peptides. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2009. http://dx.doi.org/10.1135/css200911098.

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Georgieva, Nelly, Dilyana Dimitrova, Tsvetelina Foteva, Veronika Nemska, and Dancho Danalev. "Synthesis and study of modified Temporin analogs with unnatural amino acids Citrulline and Ornithine as potential antibacterial agents." In 37th European Peptide Symposium. The European Peptide Society, 2024. http://dx.doi.org/10.17952/37eps.2024.p1070.

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Kimoto, Michiko, Tsuneo Mitsui, Yoko Harada, Akira Sato, Shigeyuki Yokoyama, and Ichiro Hirao. "Site-specific incorporation of fluorescent 2-amino-6-(2-thienyl)purine into RNA by transcription using an unnatural base pair system." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810355.

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Gitsov, Ivan. "“Synthesis of unnatural poly(amino acid)s and their dendritic derivatives by polymer-enhanced laccase complexes”." In 2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC). IEEE, 2015. http://dx.doi.org/10.1109/nebec.2015.7117036.

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Reports on the topic "Unnatural amino acids"

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Schultz, Peter G. In Vivo Incorporation of Unnatural Amino Acids into Proteins. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada392129.

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Jones, Anne K. Engineering Oxidoreductases: Utilization of an Unnatural Amino Acid to Create Artificial Hydrogenases. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada557996.

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Lester, Henry A. Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada299991.

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