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Journal articles on the topic 'Unorthodox treatment'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Travis, J. "Unorthodox Treatment Stirs Controversy." Science 258, no. 5080 (1992): 219. http://dx.doi.org/10.1126/science.258.5080.219.

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Newell, Susan M., James H. Price, Reemt R. Baumann, and Stephen M. Roberts. "Utility of the Modified Health Belief Model in Predicting Compliance with Treatment by Adult Patients with Advanced Cancer." Psychological Reports 59, no. 2 (1986): 783–91. http://dx.doi.org/10.2466/pr0.1986.59.2.783.

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The purpose of this study was twofold. The primary purpose was to assess why some adult patients with advanced cancer who attend local outpatient clinics used unorthodox cancer therapies while others did not. Another purpose was to survey the prevalence of use of such unorthodox treatment by these patients. A questionnaire was developed based on the Health Belief Model, with an emphasis on cancer treatment. In addition, locus of control questions were developed to measure the participants' locus-of-control orientation about cancer treatment. Also included were attitude questions based on Ajzen

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Bjarnason, Ingvar. "Unorthodox treatment for irritable bowel syndrome?" European Journal of Gastroenterology & Hepatology 17, no. 1 (2005): 1–3. http://dx.doi.org/10.1097/00042737-200501000-00001.

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Beeres, F., S. Rhemrev, R. Kooijman, and M. Hogervorst. "Unorthodox Treatment of a Very Rare Forearm Injury." Osteosynthesis and Trauma Care 14, no. 4 (2006): 225–29. http://dx.doi.org/10.1055/s-2006-942160.

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Katelaris, C. H., K. Y. Yan, J. M. Weiner, R. J. Heddle, and M. S. Stuckey. "Unorthodox methods of diagnosis and treatment of allergic diseases." Medical Journal of Australia 152, no. 2 (1990): 107–8. http://dx.doi.org/10.5694/j.1326-5377.1990.tb124499.x.

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Koenemann, Falk H. "Unorthodox Thoughts about Deformation, Elasticity, and Stress." Zeitschrift für Naturforschung A 56, no. 12 (2001): 794–808. http://dx.doi.org/10.1515/zna-2001-1202.

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Abstract The nature of elastic deformation is examined in the light of the potential theory. The concepts and mathematical treatment of elasticity and the choice of equilibrium conditions are adopted from the mechanics of discrete bodies, e. g., celestial mechanics; they are not applicable to a change of state. By nature, elastic deformation is energetically a Poisson problem since the buildup of an elastic potential implies a change of the energetic state in the sense of thermodynamics. In the Euler-Cauchy theory, elasticity is treated as a Laplace problem, implying that no change of state oc

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Naqvi, Iftikhar Haider, Abu Talib, Gohar Baloch, Khalid Mahmood, and Zahid Qadari. "HEPATITIS B AND C: FREQUENCY, MODES OF TRANSMISSION AND RISK FACTORS ALONG WITH SOME UNORTHODOX ROUTES OF SPREAD." Pakistan Journal of Public Health 9, no. 3 (2020): 161–65. http://dx.doi.org/10.32413/pjph.v9i3.273.

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Background: Pakistan's being a country placed in intermediate endemicity zone of HBV and HCV, with rising population, there is lack scarcity of knowledge about transmission of risk factors specially unorthodox and frequency of this health challenge. Methods: A retrospective case control study where case records of all patients aged from 18 - 70 years from 2012 to 2017 with either gender diagnosed as chronic hepatitis B and C were included. Information about shave from barber-shop, sharing of toothbrush at home, tattooing, cautery, and ear piercing were collected. Information about unorthodox r

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Muthny, F. A., and C. Bertsch. "Why Some Cancer Patients Use Unorthodox Treatment and Why Others Do Not." Oncology Research and Treatment 20, no. 4 (1997): 320–25. http://dx.doi.org/10.1159/000218963.

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Nikolaou, Michail, Georgios Nikolaou, Antonia Digklia, et al. "Immunotherapy of Cancer: Developments and Reference Points, an Unorthodox Approach." Integrative Cancer Therapies 18 (January 2019): 153473541982709. http://dx.doi.org/10.1177/1534735419827090.

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Oncology is currently a sector of medical science with accelerated progress due to rapid technological development, the advancement in molecular biology, and the invention of many innovative therapies. Immunotherapy partially accounts for this advance, since it is increasingly playing an important role in the treatment of cancer patients, bringing on a sense of hope and optimism through a series of clinical studies and cases with spectacular results. Immunotherapy, after the initial successes it experienced in the early 20th century, was forgotten after chemotherapy and radiotherapy prevailed

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Anyaehie, UE, O. Ede, EO Edomwonyi, et al. "Discharge against Medical Advice in Eight Tertiary Hospitals in Nigeria: A Prospective Study." Nigerian Journal of Clinical Practice 26, no. 12 (2023): 1927–33. http://dx.doi.org/10.4103/njcp.njcp_511_23.

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Background: Discharge against medical advice (DAMA) is when a patient decides to leave the hospital without the consent of the treating physician. It poses serious clinical, ethical, and legal challenges to the individual physician as well as the hospital. Aim: To determine the prevalence and reasons for DAMA in orthopedic departments of eight tertiary hospitals in Nigeria. Materials and Methods: This was a prospective multi-center descriptive study undertaken in eight tertiary Nigerian hospitals. Consecutive patients who requested for DAMA within 1 year of the study and who consented to parti

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Cestero, Joseph, Hassan Bukhary, Eddy Carrillo, et al. "Refractory chylothorax following a transhepatic gunshot wound to the abdomen requiring unorthodox surgical treatment." Journal of Surgical Case Reports 2010, no. 6 (2010): 3. http://dx.doi.org/10.1093/jscr/2010.6.3.

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12

Beji, Serdar. "An Unorthodox Arrangement of Boussinesq-Type Wave Equations for Accurate and Robust Numerical Treatment." Journal of Marine Science and Engineering 11, no. 10 (2023): 1936. http://dx.doi.org/10.3390/jmse11101936.

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A set of Boussinesq-type wave equations with enhanced dispersion characteristics is presented for accurate, efficient, and robust numerical treatment. New arrangement uses three different velocity variables simultaneously in order to keep continuity and momentum equations in simplest conservation forms while improving the dispersion characteristics. This approach allows us to retain all the nonlinear contributions with minimum number of terms. Spatial and time-dependent variations of the seabed are fully accounted for and the effect of external free surface pressure is included. A numerical sc

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Berry, Gunnel. "Clinical Outcome Review: A Retrospective Assessment of 171 Patients Referred for Physiotherapy Treatment after Whiplash Injury by Medical Insurance Intermediaries." British Journal of Healthcare and Medical Research 12, no. 03 (2025): 70–89. https://doi.org/10.14738/bjhr.1203.18786.

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The purpose of this review is to share outcomes from 171 patients of acute and chronic grade 0-2 whiplash injury referred for physiotherapy treatment by nine insurance intermediaries after a road traffic accident. An unorthodox method of treatment and assessment was used and the review is retrospective. After assessment, a prediction of outcome including proposed method, number of treatments and improvement measured in percentages was delivered to the insurance intermediaries for approval prior to commencing treatment. In effect, the insurance intermediaries became external assessors in all ca

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T., E. Diamond, E. B. Ibeanusi S., and C. Echem R. "Traditional Bone Setters in Port Harcourt Nigeria: Perception, Patronage and Practice: A Prospective Cross-sectional Study." British Journal of Medicine & Medical Research 21, no. 12 (2017): 1–8. https://doi.org/10.9734/BJMMR/2017/34332.

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<strong>Background: </strong>Treatment of musculoskeletal disorders by Traditional Bone Setters (TBS) is as old as man’s effort at caring for his bone. In spite of the numerous limb-deforming and limb-threatening complications caused by this unorthodox method of care, the TBS still enjoy high patronage in the developing world. <strong>Aim:</strong> To evaluate the patronage and practice as well as the perception of patients receiving orthopaedic care at the University of Port Harcourt Teaching Hospital (UPTH) concerning traditional bone setters. <strong>Methods:</strong> A prospective non-rand

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GÂTEBLÉ, GILDAS, DOMINIQUE FLEUROT, ULRICH MEVE, and SIGRID LIEDE-SCHUMANN. "An unorthodox, new endemic species in New Caledonian Marsdenia (Apocynaceae, Asclepiadoideae, Marsdenieae)." Phytotaxa 405, no. 3 (2019): 121. http://dx.doi.org/10.11646/phytotaxa.405.3.3.

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In the course of the writing of the Flore de la Nouvelle-Calédonie treatment for Asclepiadoideae, Periplocoideae and Secamonoideae, several new species have already arisen partly due to more intensive field work and to a renewed interest in this group of plants. In December 2018, another striking and unorthodox new species was spotted and collected on the flanks of the Kopéto massif mining site. Because this new species has morphological characters from three genera (Dischidia, Gymnema and Marsdenia), further studies, especially molecular, were needed to assess its relationships. These studies

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Siasios, Ioannis, Aggeliki Fotiadou, George Fotakopoulos, Maria Ioannou, Vassilios Anagnostopoulos, and Konstantinos Fountas. "Primary Diffuse Large B-Cell Lymphoma of Central Nervous System: Is Still Surgery an Unorthodox Treatment?" Journal of Clinical Medicine Research 7, no. 12 (2015): 1007–12. http://dx.doi.org/10.14740/jocmr2376w.

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Nyarko, Eric, Edmund Fosu Agyemang, Ebenezer Kwesi Ameho, Louis Agyekum, José María Gutiérrez, and Eduardo Alberto Fernandez. "A supervised machine learning statistical design of experiment approach to modeling the barriers to effective snakebite treatment in Ghana." PLOS Neglected Tropical Diseases 18, no. 12 (2024): e0012736. https://doi.org/10.1371/journal.pntd.0012736.

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Background Snakebite envenoming is a serious condition that affects 2.5 million people and causes 81,000–138,000 deaths every year, particularly in tropical and subtropical regions. The World Health Organization has set a goal to halve the deaths and disabilities related to snakebite envenoming by 2030. However, significant challenges in achieving this goal include a lack of robust research evidence related to snakebite incidence and treatment, particularly in sub-Saharan Africa. This study aimed to combine established methodologies with the latest tools in Artificial Intelligence to assess th

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Spike, B. P., R. J. Wright, S. D. Danielson, and R. W. Pryor. "Chinch Bug Control with Sevin XLR Plus and Liquid Ivory Soap, 1991." Insecticide and Acaricide Tests 17, no. 1 (1992): 259. http://dx.doi.org/10.1093/iat/17.1.259.

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Abstract This test was conducted to compare the efficacy of Ivory* soap and water, an unorthodox treatment used by some NE farmers to control CB, with an insecticide labeled for use on CB. The experiment was arranged in a randomized complete block design with 3 replications. Each treated plot was approx. 10 × 15 m. The sorghum was bordered on the east by CB-infested winter wheat. Treatments were applied at dusk 2 Jul 1991 to 5-6 leaf sorghum plants with drop nozzles (flat fan) directed at the base of the plant, 21.7 gal/ acre with tractor speed of 1 mph. The control treatment consisted of runn

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Ullah, Muneeb. "Unorthodox approach to management of Empyema Gallbladder during COVID pandemic in a developing country." Journal of Islamabad Medical & Dental College 11, no. 1 (2022): 53–57. http://dx.doi.org/10.35787/jimdc.v11i1.811.

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Laparoscopic Cholecystectomy has established itself as the standard of care for treatment of gallstone disease. The management of high risk patients becomes challenging when they present in Emergency with complications of gallstone disease. These patients are generally elderly with multiple co-morbids; in particular cardiac patients with uncontrolled diabetes present late with acute cholecystitis and have systemic inflammation. The timing of surgery, extent of pre-operative optimization and use of laparoscopy for surgery continue to be utilized differently in such patients across the world esp

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Fonseca, Joaquim. "Fingolimod Real World Experience: Efficacy and Safety in Clinical Practice." Neuroscience Journal 2015 (November 26, 2015): 1–7. http://dx.doi.org/10.1155/2015/389360.

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Fingolimod is a multiple sclerosis treatment licensed in Europe since 2011. Its efficacy has been demonstrated in three large phase III trials, used in the regulatory submissions throughout the world. As usual, in these trials the inclusion and exclusion criteria were designed to obtain a homogeneous population, with interchangeable characteristics in the different treatment arms. Although this is the best strategy to achieve a robust answer to the investigation question, it does not guaranty the treatment efficacy in the clinical practice, since in the real world there are concomitant treatme

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Hajiabbasi, Maryam, Nagma Shah, Navin Bhatt, and Muhammad Saad Malik. "Atypical haemolytic uremic syndrome in a patient with severe Babesiosis." BMJ Case Reports 17, no. 6 (2024): e260735. http://dx.doi.org/10.1136/bcr-2024-260735.

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Babesiosis is a tick-borne parasitic infection that can result in various haematological complications. This case report discusses a patient with severe Babesiosis complicated by an unorthodox presentation of Babesiosis-associated haemolytic uremic syndrome. Discussed here is the patient’s clinical course and the management strategies employed, with an emphasis on early recognition and treatment of renal failure in the context of severe Babesiosis. Haematologic manifestations of Babesia are common and the severity of disease is dependent on parasite load. While treatment options such as red bl

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Bocci, V. "A reasonable Approach for the Treatment of HIV Infection in the Early Phase with Ozonetherapy (Autohaemotherapy). How ‘Inflammatory’ Cytokines may have A therapeutic Role." Mediators of Inflammation 3, no. 5 (1994): 315–21. http://dx.doi.org/10.1155/s0962935194000438.

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Immunoregulatory cytokines produced by the TH1 subset and by CD8+T lymphocytes appear to brake naturally and sometimes arrest the progress of HIV infection in the early phase. It appears reasonable to assume that a mild and equilibrated stimulation of the immune system may prevent or delay the fatal transition towards the prevalent production of TH2-type cytokines. The problem is how to stimulate the immune system in a physiological fashion. In the last 7 years we have clarified the main mechanisms of action of an unorthodox immunotherapeutic method first used 40 years ago. Optimized autohaemo

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Kemmesies, Uwe E. "What Do Hamburgers and Drug Care Have in Common: Some Unorthodox Remarks on the McDonaldization and Rationality of Drug Care." Journal of Drug Issues 32, no. 2 (2002): 689–708. http://dx.doi.org/10.1177/002204260203200222.

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This paper traces the question of whether there is a growing process of rationalization underlying drug policy and drug treatment, in the sense of the “McDonaldization” thesis established by Ritzer (2000). Taking Germany as an example, there is some evidence that endeavors to achieve enhanced efficiency may actually lead to a lack of rationality. Here we explore the historical background of this McDonaldization process as it relates to drug policy and treatment in Germany. Is it possible to escape from the “irrationality of rationality,” that is, the intense efforts directed at efficiency in d

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Szram, Mariusz. "Wczesnochrześcijańskie ruchy paramonastyczne na podstawie Diversarum hereseon liber Filastriusza z Brescii oraz innych katalogów herezji." Vox Patrum 70 (December 12, 2018): 217–26. http://dx.doi.org/10.31743/vp.3206.

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The catalog of the heresies of Filastrius of Brescia, like other early Christian collections of informations about heterodox movements at the time, testifies the existence of groups characterized by excessively rigorous asceticism. Their description is the subject of the article. Most of these unorthodox paramonastic movements were based on the Gnostic and Manichean assumptions. The groups that accentuated the exaggerated role of prayer, among which the Messialians were the leaders, have gained wide coverage. Descriptions of their activities take up a lot of space in the early Christian cata

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Shah, Manjari, and Disha Tiwari. "Vaginal Vibrator as an alternative to Dilator in vaginal stenosis post pelvic radiotherapy in cervical cancer." Asian Journal of Medical Sciences 12, no. 10 (2021): 171–74. http://dx.doi.org/10.3126/ajms.v12i10.37682.

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Sexuality, post cancer treatment is the most unattended aspect of patient doctor communication. Quality of life in a cancer survivor should be addressed without any inhibitions so that patient does not suffer from any kind of psychological distress. Vaginal stenosis is a well-known side effect of pelvic radiotherapy, which we have tried to address in our study. We have used vaginal vibrator as an alternative to vaginal dilator in two of our patients on experimental basis post vaginal dilator. Both the patients gave feedback that vibrator is comparatively easy to use and less painful. On follow

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Hansen, Scott K., Sachin Pandey, Satish Karra, and Velimir V. Vesselinov. "CHROTRAN 1.0: A mathematical and computational model for in situ heavy metal remediation in heterogeneous aquifers." Geoscientific Model Development 10, no. 12 (2017): 4525–38. http://dx.doi.org/10.5194/gmd-10-4525-2017.

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Abstract. Groundwater contamination by heavy metals is a critical environmental problem for which in situ remediation is frequently the only viable treatment option. For such interventions, a multi-dimensional reactive transport model of relevant biogeochemical processes is invaluable. To this end, we developed a model, chrotran, for in situ treatment, which includes full dynamics for five species: a heavy metal to be remediated, an electron donor, biomass, a nontoxic conservative bio-inhibitor, and a biocide. Direct abiotic reduction by donor–metal interaction as well as donor-driven biomass

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DAWES, LAURA L. "‘Just a Quack Who Can Cure Cancer’: John Braund, and Regulating Cancer Treatment in New South Wales, Australia." Medical History 57, no. 2 (2013): 206–25. http://dx.doi.org/10.1017/mdh.2012.103.

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AbstractIn 1948 the New South Wales government instituted an inquiry into the claims of John Braund – a 78-year-old self-described ‘quack’ – that his secret treatment had cured 317 cancer sufferers. The ‘Braund controversy’, as it became known, was one of Australia’s most prominent cases of medical fraud. This paper examines that controversy and its effects on cancer philanthropy, medical research, and especially on legislation regulating treatment providers up to the present. With the Braund controversy in mind, the New South Wales (NSW) parliament struggled to develop legislation that would

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Arsenijevic, Tatjana, Jason Perret, Jean-Luc Van Laethem, and Christine Delporte. "Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases." International Journal of Molecular Sciences 20, no. 20 (2019): 5052. http://dx.doi.org/10.3390/ijms20205052.

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Aquaporins are a family of transmembrane proteins permeable to water. In mammals, they are subdivided into classical aquaporins that are permeable to water; aquaglyceroporins that are permeable to water, glycerol and urea; peroxiporins that facilitate the diffusion of H2O2 through cell membranes; and so called unorthodox aquaporins. Aquaporins ensure important physiological functions in both exocrine and endocrine pancreas. Indeed, they are involved in pancreatic fluid secretion and insulin secretion. Modification of aquaporin expression and/or subcellular localization may be involved in the p

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Nady, Doaa Sayed, Afnan Hassan, Muhammad Umair Amin, Udo Bakowsky, and Sherif Ashraf Fahmy. "Recent Innovations of Mesoporous Silica Nanoparticles Combined with Photodynamic Therapy for Improving Cancer Treatment." Pharmaceutics 16, no. 1 (2023): 14. http://dx.doi.org/10.3390/pharmaceutics16010014.

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Cancer is a global health burden and is one of the leading causes of death. Photodynamic therapy (PDT) is considered an alternative approach to conventional cancer treatment. PDT utilizes a light-sensitive compound, photosensitizers (PSs), light irradiation, and molecular oxygen (O2). This generates cytotoxic reactive oxygen species (ROS), which can trigger necrosis and/ or apoptosis, leading to cancer cell death in the intended tissues. Classical photosensitizers impose limitations that hinder their clinical applications, such as long-term skin photosensitivity, hydrophobic nature, nonspecifi

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Zhang, Yuehui, Xiaozhu Guo, Shuting Ma, et al. "The Treatment with Complementary and Alternative Traditional Chinese Medicine for Menstrual Disorders with Polycystic Ovary Syndrome." Evidence-Based Complementary and Alternative Medicine 2021 (May 17, 2021): 1–19. http://dx.doi.org/10.1155/2021/6678398.

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Polycystic ovary syndrome (PCOS) is a frequent gynecological female endocrinopathy, characterized by chronic anovulation, hyperandrogenism, and insulin resistance (IR). Menstrual disorders are one of the main clinical manifestations of PCOS. Other symptoms include hirsutism and/acne. At present, the treatment of PCOS with irregular menstruation is mainly based on oral contraceptives, but there are some side effects and adverse reactions. In recent years, more and more attention has been paid to the complementary and alternative medicine (CAM), which has been widely used in clinical practice. M

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Eaton, James E., Matthew T. Meriweather, Bassel W. Abou‐Khalil, and Hasan H. Sonmezturk. "Avoiding anaesthetics after multiple failed drug‐induced comas: an unorthodox approach to management of new‐onset refractory status epilepticus (NORSE)." Epileptic Disorders 21, no. 5 (2019): 483–91. http://dx.doi.org/10.1684/epd.2019.1104.

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ABSTRACT New‐onset refractory status epilepticus (NORSE) is a rare, poorly understood and often catastrophic condition. There is little guidance available for management. Here, we describe the course of a 19‐year‐old man with NORSE who was treated successfully with a new approach. Our patient was initially treated with first‐, second‐ and third‐line agents including a total of seven failed drug‐induced coma courses until the 30 th day of hospitalization. When withdrawal of care was contemplated, management was then assumed by dedicated epileptologists and treatment course was changed. An unort

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GOLDKAMP, JOHN S. "Miami's Treatment Drug Court for Felony Defendants: Some Implications of Assessment Findings." Prison Journal 74, no. 2 (1994): 110–66. http://dx.doi.org/10.1177/0032855594074002002.

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One of the most innovative responses to the dramatic increase in the drug-caseloads of the 1980s in American courts was the Miami Drug Court, a treatment-oriented drug court that sought to bring substance abuse treatment to bear on the problems of drug-involved felony defendants in a diversionary, alternative processing approach. The treatment drug court model pioneered by Dade County officials in 1989 defined a new, hands-on role for the judge in managing the processing and treatment of defendants and an unorthodox courtroom approach that was based on teamwork among defense, prosecution, trea

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Hornsey, Michael, Christopher Longshaw, Lynette Phee, and David W. Wareham. "In VitroActivity of Telavancin in Combination with Colistin versus Gram-Negative Bacterial Pathogens." Antimicrobial Agents and Chemotherapy 56, no. 6 (2012): 3080–85. http://dx.doi.org/10.1128/aac.05870-11.

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ABSTRACTThe treatment of Gram-negative infections is increasingly compromised by the spread of resistance. With few agents currently in development, clinicians are now considering the use of unorthodox combination therapies for multidrug-resistant strains. Here we assessed thein vitroactivity of the novel lipoglycopeptide telavancin (TLV) when combined with colistin (COL) versus 13 Gram-negative type strains and 66 clinical isolates. Marked synergy was observed in either checkerboard (fractional inhibitory concentration index [FICI], <0.5; susceptibility breakpoint index [SBPI], >2) or t

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Phee, Lynette M., Jonathan W. Betts, Binutha Bharathan, and David W. Wareham. "Colistin and Fusidic Acid, a Novel Potent Synergistic Combination for Treatment of Multidrug-Resistant Acinetobacter baumannii Infections." Antimicrobial Agents and Chemotherapy 59, no. 8 (2015): 4544–50. http://dx.doi.org/10.1128/aac.00753-15.

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ABSTRACTThe spread of multidrug-resistantAcinetobacter baumannii(MDRAB) has led to the renaissance of colistin (COL), often the only agent to which MDRAB remains susceptible. Effective therapy with COL is beset with problems due to unpredictable pharmacokinetics, toxicity, and the rapid selection of resistance. Here, we describe a potent synergistic interaction when COL was combined with fusidic acid (FD) againstA. baumannii. Synergyin vitrowas assessed against 11 MDRAB isolates using disc diffusion, checkerboard methodology (fractional inhibitory concentration index [FICI] of ≤ 0.5, susceptib

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Stolevski, Vlado, Ilija Zdravkov, and Aleksandar Dimovski. "Isolated expressive aphasia caused by acute subdural hematoma: case report and literature review." International Surgery Journal 11, no. 12 (2024): 2121–25. http://dx.doi.org/10.18203/2349-2902.isj20243558.

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The occurrence of aphasia as an isolated and dominant clinical feature of acute subdural hematoma (aSDH) has been rarely mentioned in the available literature. Being the most common focal intracranial lesion, subdural hematomas (SDH) pose a clinical challenge, especially when presented with unorthodox clinical features. We report a case of a patient with a traumatic aSDH, presenting with intense frontal headaches and normal neurological examination. On the 3rd postadmission day, he developed expressive dysphasia which progressed to aphasia, with neurological examination findings of an upper mo

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Kennedy, Sidney. "Psychiatry in Canada." Psychiatric Bulletin 13, no. 7 (1989): 370–72. http://dx.doi.org/10.1192/pb.13.7.370.

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There are two episodes which remain in my mind from the first night I was on call at the Clarke Institute of Psychiatry, Toronto in 1980. The first person I assessed in the Emergency Room was a young university student in her early twenties who had been reading “Jung” and urgently needed to discuss “archetypes and the animus”; the second incident some hours later involved a middle aged man who was manic on admission and responded rapidly to the 10 mg of haloperidol I administered intravenously in front of a silent and, as I later discovered, astonished night nurse and junior resident. The pati

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Diamond, James A. "The Use of Midrash in Maimonides' Guide of the Perplexed: Decoding the Duality of the Text." AJS Review 21, no. 1 (1996): 39–60. http://dx.doi.org/10.1017/s0364009400007613.

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In the introduction to his philosophical magnum opus, the Guide of the Perplexed, Maimonides provides us with a rationale for the composition of this work as well as instructions for the targeted reader on how to decipher its elusive and enigmatic style. Such devices as contradiction, diffuse and seemingly discordant treatment of subject matter, and deliberate ruses are employed to accommodate both halakhic legal constraints on the overt teaching of physics and metaphysics and the wide intellectual disparity of his potential readers. The sensitive nature of the topics to be explored demands an

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Uguru, Nkolika, Obinna Onwujekwe, Chibuzo Uguru, Udochukwu Ogu, Chinenye Okwuosa, and Chinyere Okeke. "Oral health-seeking behavior among different population groups in Enugu Nigeria." PLOS ONE 16, no. 2 (2021): e0246164. http://dx.doi.org/10.1371/journal.pone.0246164.

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Introduction This study investigates the oral health-seeking behaviour of households and its influence on demand for dental caries treatment services in Enugu state Nigeria. Methods A quantitative descriptive cross-sectional study was used to explore the oral health seeking pattern of 378 urban and 348 rural household respondents in Enugu state Nigeria. The study explored dental caries treatment-seeking, oral health behavior of respondents using the three dynamics of the Andersen and Newman health utilization model; predisposing, enabling and need factors. Findings Recommendations from communi

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Mütze, Witold, Ralf N. Breuker та Manfred Hauser. "The Glu-Modification of α-Tubulin in the Feeding Apparatus of the Primitive Flagellate Entosiphon sulcatum Is Only Apparent after Detergent Treatment". Zeitschrift für Naturforschung C 53, № 1-2 (1998): 125–34. http://dx.doi.org/10.1515/znc-1998-1-222.

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Abstract Using specific monoclonal antibodies, we investigated the distribution of post-translational modified Tyr-and Glu-tubulins during interphase of the primitive flagellate Entosiphon sulcatum. Immunofluorescence studies of simultaneously permeabilized and fixed cells revealed that microtubular structures comprising Ca2⊕-labile subpellicular and flagellar MTs and Ca2⊕-stable MTs in the siphon complex (feeding organelle) reacted surprisingly unorthodox with antibodies against Tyr-and Glu-tubulin: Unexpectedly, the siphon complex consisting of Ca2⊕-stable MTs appeared exclusively Tyr-posit

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Majera, Dusana, Zdenek Skrott, Katarina Chroma, Joanna Maria Merchut-Maya, Martin Mistrik, and Jiri Bartek. "Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway." Cells 9, no. 2 (2020): 469. http://dx.doi.org/10.3390/cells9020469.

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Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in multiple pathways, as an unsuspected cancer cell vulnerability. While we reported that NPL4 is targeted by the anticancer metabolite of DSF, the bis-diethyldithiocarbamate-copper complex (CuET), the exact, apparently multifaceted mechanism(s) through which the CuET-induced aggregation of NPL4 kills cancer cells remains to be fully elucidated. Given the pronounced sensitivity to CuET in t

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Adeyemi, Oluwafemi, and Kenneth Atoe. "Immune Thrombocytopenic Purpura in Pregnancy: A Case Report in a Health Institution in Benin City, Nigeria." Cognizance Journal of Multidisciplinary Studies 3, no. 8 (2023): 1045–53. http://dx.doi.org/10.47760/cognizance.2023.v03i08.027.

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In comparison with reports among Caucasians, immune thrombocytopaenic purpura (ITP) is thought to be uncommon in native black Africans and persons of African ancestry worldwide. The uncommon presentation of these instances provides the information required for the collection of data for prospective research and as a foundation for improving illness management techniques aimed at promoting feto-maternal health. This paper offers a retrospective review of a 32-year-old woman who was diagnosed with ITP in her first trimester of pregnancy following a two-day history of nasal bleeding. Four years p

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Oluwafemi, Adeyemi, and Atoe Kenneth. "Immune Thrombocytopenic Purpura in Pregnancy: A Case Report in a Health Institution in Benin City, Nigeria." Cognizance Journal of Multidisciplinary Studies (CJMS) 3, no. 8 (2023): 1045–53. https://doi.org/10.47760/cognizance.2023.v03i08.027.

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In comparison with reports among Caucasians, immune thrombocytopaenic purpura (ITP) is thought to be uncommon in native black Africans and persons of African ancestry worldwide. The uncommon presentation of these instances provides the information required for the collection of data for prospective research and as a foundation for improving illness management techniques aimed at promoting feto-maternal health. This paper offers a retrospective review of a 32-year-old woman who was diagnosed with ITP in her first trimester of pregnancy following a two-day history of nasal bleeding. Four years p

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Morhason-Bello, Imran O., and Adeniyi F. Fagbamigbe. "Association between Knowledge of Sexually Transmitted Infections and Sources of the Previous Point of Care among Nigerians: Findings from Three National HIV and AIDS Reproductive Health Surveys." International Journal of Reproductive Medicine 2020 (January 3, 2020): 1–11. http://dx.doi.org/10.1155/2020/6481479.

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Background. Adequate knowledge of sexually transmitted infections (STIs) is critical for effective control of disease. Health education/counselling at the point of care provides ample opportunities to improve knowledge of patient seeking treatment. There is no study from Nigeria that investigates association between sources of previous point of care of STI and quality of knowledge of people on STI. We hypothesised that previous treatment of STI will be associated with better knowledge of STI and HIV infection. Methods. Three consecutives nationally representative cross-sectional surveys on HIV

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Nuñez Campos, Daniel Mauricio, Liliana Villamil Núñez, Oscar Libardo Gómez Acevedo, and María Camila Peña Pineda. "The VIP patient syndrome in Latin America is known as “The recommended patient syndrome” a tale of unfortunate decisions and complications." Revista Cuarzo 25, no. 1 (2019): 16–20. http://dx.doi.org/10.26752/cuarzo.v25.n1.391.

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When a VIP patient or a patient who has an economic, social or family relationship with the doctors who treat them, arrive to the ER there is a subtle risk of making unorthodox decisions, Also, wasting resources, breaking standards of care and in the lowest scenario causing unintended complications to the patient. Case Report: We report a 55-year-old patient related to a physician. She was admitted to the emergency room due to abdominal pain, on admission was suspected appendicitis versus abdominal mass, an abdominal CT scan with contrast was performed and she developed an allergic react

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Edet, Bassey Eyo, Emmanuel Aniekan Essien, Emmanuel Omamurhomu Olose, Chidi John Okafor, Molly Unoh Ogbodum, and Faithful Miebaka Daniel. "Pattern and causes of missed appointments in a Nigerian Psychiatric Hospital: A cross-sectional study." Medicine 103, no. 24 (2024): e38564. http://dx.doi.org/10.1097/md.0000000000038564.

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Psychiatric patients exhibit a higher rate of missed appointments compared to other medical specialities, leading to provider frustration, increased relapse, and suboptimal outcomes. This study investigates the patterns and correlates of missed appointments among outpatients at the Federal Neuropsychiatric Hospital in Calabar, Nigeria. A cross-sectional study involving 403 consecutive outpatient clinic attendees was conducted. The study questionnaire inquired about sociodemographic characteristics and hospital utilization. The Oslo Social Support Scale, the Internalized Stigma of Mental Illnes

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Geisler, John. "2,4 Dinitrophenol as Medicine." Cells 8, no. 3 (2019): 280. http://dx.doi.org/10.3390/cells8030280.

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In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950’s to suggest that warfarin, a rat poison, could be repositioned into a breakthrough drug in humans to protect against strokes as a blood thinner. Yet it was approved in 1954 as Coumadin® and has been prescribed to billions of patients as a standard of care. Similarly, no one can forget the horrific effects of thalidomide, prescribed or available without a prescri

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Rodenko, Boris, Martin J. Wanner, Abdulsalam A. M. Alkhaldi, et al. "Targeting the Parasite's DNA with Methyltriazenyl Purine Analogs Is a Safe, Selective, and Efficacious Antitrypanosomal Strategy." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 6708–16. http://dx.doi.org/10.1128/aac.00596-15.

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ABSTRACTThe human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality, and economic hardship. Drug resistance and toxic side effects of old drugs call for novel and unorthodox strategies for new and safe treatment options. We designed methyltriazenyl purine prodrugs to be rapidly and selectively internalized by the parasite, after which they disintegrate into a nontoxic and naturally occurring purine nucleobase, a simple triazene-stabilizing group, and the active toxin: a methyldiazonium cation capable of damaging DNA by

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Barrett, Matthew, Josiane Boyne, Julia Brandts, et al. "Artificial intelligence supported patient self-care in chronic heart failure: a paradigm shift from reactive to predictive, preventive and personalised care." EPMA Journal 10, no. 4 (2019): 445–64. http://dx.doi.org/10.1007/s13167-019-00188-9.

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AbstractHeart failure (HF) is one of the most complex chronic disorders with high prevalence, mainly due to the ageing population and better treatment of underlying diseases. Prevalence will continue to rise and is estimated to reach 3% of the population in Western countries by 2025. It is the most important cause of hospitalisation in subjects aged 65 years or more, resulting in high costs and major social impact. The current “one-size-fits-all” approach in the treatment of HF does not result in best outcome for all patients. These facts are an imminent threat to good quality management of pa

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Isler, H., H. Hasenfratz, and T. O'Neill. "A Sixth-Century Irish Headache Cure and Its Use in a South German Monastery." Cephalalgia 16, no. 8 (1996): 536–40. http://dx.doi.org/10.1046/j.1468-2982.1996.1608536.x.

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Medieval headache treatment is largely unknown. Medieval incantations against headache enumerate bodily organs to be protected. One 8th-century Latin hymn from Lake Constance using this device is addressed to St. Aid “mechprech”, who has been identified as Aed Mac Brice, Bishop of Killare, 6th century. This Irish Saint inspired unusual legends by some rather unorthodox activities: He abducted a young girl as hostage while his inheritance was withheld, but at the same time was seen surrounded by angels. He prayed for a nun who was pregnant and made the pregnancy vanish by a miracle, and he repl

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Burchmore, Susan. "Traditional Exegesis and the Question of Guilt in the Old English ‘Genesis B’." Traditio 41 (1985): 117–44. http://dx.doi.org/10.1017/s0362152900006875.

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For many years, scholars felt that the unusual elements in Genesis B exonerated Adam and Eve by portraying them as innocent victims of a diabolical deception. In particular, the tempter's apparent disguise as an angel, Eve's vision of heaven, and the consistent emphasis throughout the temptation scene on Adam's and Eve's wholehearted loyalty to God made it difficult to confirm their guilt or to identify their sin. For some time, therefore, Genesis B's sympathetic portrayal of the first parents was accepted as one of the poem's strange unorthodoxies, yet another puzzle in a maze of puzzles. How

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