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Dissertations / Theses on the topic 'Unsaturated ketone'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Zinovyeva, Lyudmyla. "Darstellung und Reaktionen einiger ß,Y-ungesättigter Ketone - Preparation and reactivity of some ß,Y-unsaturated ketones." Gerhard-Mercator-Universitaet Duisburg, 2003. http://www.ub.uni-duisburg.de/ETD-db/theses/available/duett-09182003-170256/.

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The reactivity of the polycyclic ß,Y-unsaturated ketones under different conditions were investigated. The titled ketons were reacted with Lithiumaluminiumhidrid and Grignard reagents with following dehydratation of the resulted secondary and tertiary alkohol. The Bucherer reaction, thermolysis and photolysis of these ketones were carried out.

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2

Offenbacher, Jennifer M. "Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250.

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3

Mahishi, Shreesha. "Rate Enhancement Of The Catalytic Hydrogenation Of An Unsaturated Ketone By Ultrasonic Irradiation." Thesis, Indian Institute of Science, 1996. https://etd.iisc.ac.in/handle/2005/138.

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The aim of the work was to develop an understanding of the phenomenon of rate enhancement observed when a heterogeneous catalytic reaction system is irradiated by ultrasound. The system under investigation was the catalytic hydrogenation of an a, B - unsaturated ketone, using zinc dust and aqueous nickel chloride as a source of hydrogen. When a slurry of zinc particles and aqueous nickel chloride is stirred or sonicated, nickel deposits in the form of patches on the surface of the zinc particles and simultaneously, zinc dissolves into the solution in the form of zinc ions, a process called pi

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4

Mahishi, Shreesha. "Rate Enhancement Of The Catalytic Hydrogenation Of An Unsaturated Ketone By Ultrasonic Irradiation." Thesis, Indian Institute of Science, 1996. http://hdl.handle.net/2005/138.

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The aim of the work was to develop an understanding of the phenomenon of rate enhancement observed when a heterogeneous catalytic reaction system is irradiated by ultrasound. The system under investigation was the catalytic hydrogenation of an a, B - unsaturated ketone, using zinc dust and aqueous nickel chloride as a source of hydrogen. When a slurry of zinc particles and aqueous nickel chloride is stirred or sonicated, nickel deposits in the form of patches on the surface of the zinc particles and simultaneously, zinc dissolves into the solution in the form of zinc ions, a process called pi

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5

Warad, Ismail Khalil. "Diamine(phosphine)ruthenium(II) complexes and their application in the cata lytic hydrogenation of alpha,beta-unsaturated ketones in homogeneous and heterogeneous phase." [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10761327.

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6

Dostert, Karl-Heinz. "Selectivity in hydrogenation of alpha, beta-unsaturated carbonyl compounds on model palladium catalysts." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17399.

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Die Umsetzung von alpha,beta-ungesättigten Aldehyden und Ketonen mit Wasserstoff über Pd-Modellkatalysatoren wurde anhand von Molekularstrahlmethoden, kombiniert mit Infrarot-Reflexions-Absorptions-Spektroskopie (IRAS), Quadrupol-Massenspektrometrie (QMS) und Röntgen-Nahkanten-Absorptions-Spektroskopie (NEXAFS), unter wohldefinierten Ultrahochvakuumbedingungen untersucht. Das Ziel dieser Arbeit war es, ein atomistisches Verständnis der strukturellen Faktoren zu gewinnen, die die Aktivität und Selektivität eines Pd(111)-Einkristalls und Eisenoxid-geträgerter Pd-Nanopartikel für die Hydrierung d

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7

Wu, Luis Eduardo. "Synthesis of unnatural sugars from unsaturated ketones." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368669.

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8

Moody, Catherine Laura. "Improved routes to unsaturated ketones and heterocycles." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/2409/.

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The work herein comprises two distinct projects: the first involves the construction of allylic ketones and enones directly from primary alcohols, using a novel one-pot procedure. Following development of this methodology, its application to the synthesis of indolizidine alkaloid elaeokanidine A was investigated. The second research area concerns the development of a copper(II)-catalysed radical cyclisation reaction to form spirocyclic oxindoles directly from linear anilides, along with subsequent preliminary studies towards to the synthesis of spirotryprostatin A.

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9

Heal, William. "Polyleucine catalysed asymmetric epoxidation of Î±,Î²-unsaturated ketones." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272718.

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10

Torok, Daniel Seth 1963. "Diastereoselective cyclopropanations of alpha,beta-unsaturated ketals derived from chiral hydrobenzoin." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276784.

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2-Cycloalken-1-one-(-)-erythro-hydrobenzoin ketals undergo efficient and diastereoselective cyclopropanation when treated with an excess of Simmons-Smith reagent. The resulting crystalline products yield enantiomerically pure cyclopropyl compounds upon recrystallization. For example, 2-cyclohexen-1-one-(-)-erythro-hydrobenzoin ketal gave, in 90% yield, a 19:1 mixture of diastereomeric cyclopropanes as established by 62.9 MHz ¹³C NMR spectroscopy. Upon one recrystallization, diastereomerically pure cyclopropane was obtained in 78% recovery. Hydrolysis gave (+)-norcaranone of greater than 99% ee

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11

Roden, Peter John. "The gas-phase oxidation of unsaturated compounds at elevated temperatures." Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338552.

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12

Howard-Jones, Andrew Glyn. "A synthetic approach to Câ†2 symmetric guanidine bases and the synthesis of model compounds of ptilomycalin A." Thesis, Bangor University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340956.

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13

Jedudason, R. J. Bennie Ram John. "Studies on the heterogeneously catalysed asymmetric hydrogenation of α,β-unsaturated ketones". Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509964.

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14

Math, Shivanand Kumarswamy, and Shivanand Kumarswamy Math. "Diastereoselective cyclopropanation of medium and large ring alpha, beta-unsaturated homochiral ketals and enantioselective synthesis of (-)-modhephene." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184664.

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A general straightforward synthetic approach for the enantioselective construction of medium and large ring cyclopropyl ketones via diastereoselective Simmons-Smith cyclopropanation is discussed. Medium and large 2-cycloalkenone 1,4Di-O-benzyl-L-threitol ketals undergo efficient and diastereoselective cyclopropanation when treated with an excess of the Simmons-Smith reagent. The cyclopropyl ketals are obtained in 80-94% with >23:1-8:1 diastereoselectivity. The first enantioselective synthesis of (-)-modhephene, a natural product possessing the carbocyclic (3.3.3) propellane skeleton, by the us

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15

Kina, Asato. "Mechanistic studies on rhodium-catalyzed 1,4-addition of arylmetal reagents to α,β-unsaturated ketones". 京都大学 (Kyoto University), 2006. http://hdl.handle.net/2433/136711.

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16

Hutton, Thomas K. "Samarium(II)-mediated reactions of #gamma#, #delta#-unsaturated ketones : new stereoselective approaches to cyclobutanols and cyclopentanols." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275672.

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17

Sandoval, Sergio. "Tandem conjugate addition - cyclization reactors of L-methyl prolinate with [alpha,beta]-unsaturated ketones catalyzed by L-proline /." View online ; access limited to URI, 2008. http://0-digitalcommons.uri.edu.helin.uri.edu/dissertations/AAI3314459.

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18

Warad, Ismail Khalil. "Diamine(phosphine)ruthenium(II) complexes and their application in the catalytic hydrogenation of [alpha], [beta]-unsaturated [alpha, beta-unsaturated] ketones in homogeneous and heterogeneous phase Diamin(phosphin)ruthenium(II)-Komplexe und ihre Anwendung in der katalytischen Hydrierung von [alpha], [beta]-ungesättigten Ketonen in homogener und heterogener Phase /." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968855148.

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19

Fuentes, SaÌnchez Daniel. "Ketene-Claisen rearrangement of Î±,Î²-unsaturated heteroacetals and enantioselective synthesis of glycidic amides via sulfur ylides." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411094.

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20

Guasch, Savidó Joan. "Regio- and Enantioselective Synthesis of Unsaturated Amino Alcohols, Amino Ketones and Diamines as Valuable Intermediates in Organic Synthesis." Doctoral thesis, Universitat Rovira i Virgili, 2015. http://hdl.handle.net/10803/352212.

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L'objectiu d'aquesta tesis doctoral forma part d'un objectiu mes general de preparació d'anàlegs de ceramida per servir com a inhibidors de l'enzim que metabolitza la ceramida. Així doncs, amb aquest objectiu, aquest treball s'ha orientat cap al desenvolupament de rutes sintètiques que aportin un accés ràpid cap a diferents derivats d'esfingosina, que després serien acilats per formar anàlegs de ceramida. En aquest sentit el treball està dividit en dos vessants: a) Síntesis regio-i estereoselectiva d'amino alcohols insaturats a través de l'aziridinació intramolecular i posterior obertura de d

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21

Scognamillo, Sergio [Verfasser]. "Synthesis of bicyclic compounds using sequential hydroformylation and aldol condensation of cyclic ketones with unsaturated side chains / Sergio Scognamillo." Dortmund : Universitätsbibliothek Technische Universität Dortmund, 2004. http://d-nb.info/1011532905/34.

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22

Reisinger, Corinna Marie [Verfasser], Benjamin [Akademischer Betreuer] List, Hans-Günther [Akademischer Betreuer] Schmalz та Mathias [Akademischer Betreuer] Christmann. "Organocatalytic Asymmetric Epoxidations and Hydroperoxidations of α,β-Unsaturated Ketones / Corinna Marie Reisinger. Gutachter: Benjamin List ; Hans-Günther Schmalz ; Mathias Christmann". Köln : Universitäts- und Stadtbibliothek Köln, 2010. http://d-nb.info/1038017106/34.

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23

Chen, Jianxian. "I. Chemoselective catalytic hydrogenation of Ã, ß-unsaturated aldehydes and ketones using soluble copper(I) hydrides, II. Free radical alkylation of titanium(III) allyl and propargyl complexes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0005/NQ39514.pdf.

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24

Pingali, Subramanya. "Towards the Synthesis of Magnesidin." ScholarWorks@UNO, 2011. http://scholarworks.uno.edu/td/447.

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Magnesidin is a magnesium chelate of the 3-hexanoyl and 3-octanoyl tetramic acid derivatives isolated from Psuedomonas magensiorubra. Its activity against grampositive bacteria was found to be a specific target for Gingivitis, a dental plaque.Although the synthesis of magnesidin has been reported earlier, it was not reproducible. The highly polar nature and it’s ability to exhibit tautomerization makes their chemical behavior complex and difficult to predict its structure. A variety of reactions and an in depth understanding of the chemical structure is necessary to attain the synthesis of the

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25

Hansson, Lars. "Optimering i organisk syntes : betingelser, system, syntesvägar." Doctoral thesis, Umeå universitet, Kemiska institutionen, 1990. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131575.

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This thesis deals with different optimization problems encountered in organic synthesis. The use of response surface, sequential simplex and PLS techniques, for simultanious optimization of yield and suppression of side reactions is investigated. This is illustrated by an example of enamine synthesis, were a side reaction was a serious problem. The problem of efficient screening to find suitable catalysts and solvents in new reactions is also investigated. Here, the use of principal properties as selection criterion, is demonstrated with a new process for the silylation of a,ß-unsaturated keto

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26

Rkein, Batoul. "Désaromatisation d'arènes électro-appauvris par des réactions de cycloadition (4+2) The facile dearomatization of nitroaromatic compounds using lithium enolates of unsaturated ketones in conjugate additions and (4+2) formal cycloadditions." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR092.

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Les composés aromatiques sont largement accessibles, que ce soit à partir de la pétrochimie, ou de molécules naturelles. Ainsi, des efforts importants ont été faits pour convertir ces molécules simples et facilement disponibles en structures 3D complexes d’intérêts synthétiques tels que des polycycles possédant des centres tétrasubstitués, utiles par exemple dans la synthèse de produits naturels ou pharmaceutiques. Même si plusieurs méthodes efficaces de désaromatisation ont été décrites, le développement de méthodologies complémentaires reste nécessaire. Dans ce contexte, les cycloadditions (

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27

Lopez, Susana Sorina. "Chiral Boro-Phosphates in Asymmetric Catalysis: 1,4-reduction of Enones and Reductive Aldol." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6305.

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The biological activity of the pharmaceutical drugs often depends on how it fits with a receptor making stereochemistry a key component. Selective reactions can limit or avoid the mixture of enantiomers obtained. One such reaction is the selective reduction of a carbon-carbon double bond in the presence of a carbonyl. Although efficient, current asymmetric synthesis methods have limitations such as harsh reaction conditions, the high costs of chiral catalysts and the toxicity of the metal-based catalysts. Catalysts derived from small organic molecules have become an attractive alternative whic

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28

Annangudi, Palani Suresh Babu. "Lipid-based Oxidative Protein Modifications in Glaucoma." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1129558048.

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29

Chuan, Yen-Shu, та 顏淑娟. "The Michael Addition of azulenes withα.β—unsaturated ketone and their application". Thesis, 2001. http://ndltd.ncl.edu.tw/handle/76777018653955879385.

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碩士<br>中原大學<br>化學研究所<br>89<br>The five member of azulene which was tend to be negative chage was his main property. Electrophile reaction was the main proceeding reaction used in this paper survey. When the 3—position of azulene can not be substituted, azulene and methyl vinyl ketone process Michael Addition under acidic catalyzation thus synthesis 3—（2—acetylethyl）azulene derivatives. When the 2—aminoazulene derivatives and methyl vinyl ketone process Michael Addition under acidic catalyzation thus cyclization and achieve azuleno[2,1—b]pyridine derivatives. 2—methoxycarbonylmethyl—3—（2—acetyle

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30

Lin, Jing-wen, та 林靖文. "Asymmetric synthesis of (-)-brevipolide H through cyclopropanation of the α,β-unsaturated ketone". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/39930782407752386831.

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碩士<br>國立中央大學<br>化學學系<br>102<br>We utilized the C2 symmetric diene-diol 2 as the starting material, and the skeleton of ent-brevipolide H (ent-1) was prepared by the sequence of cross metathesis, cyclopropanation, Sharpless asymmetric α-hydroxylation and ring-closing-metathesis. The anti-addition of the sulfur ylide to the α,β-unsaturated enone 5 was be developed to generate the key cyclopropane moiety, whose stereochemistry was lated confirmrd by X-ray crystallography. The substrates with different hydroxyl protecting groups, i.e. ethoxymethyl ether and acetonide, lead to the different stereo-

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31

LAI, MING-YI, and 賴明義. "Study on the cyclization of unsaturated Ketone with malonate and GC/MS analysis of the product." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/72356296861945281824.

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32

Li, Deng-Hong, та 李登鴻. "Study on Addition Reaction of 3,4-Dihydroisoquinolines with γ-Hydroxy-α,β-unsaturated Phenyl Ketone at Room Temperature". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/a65778.

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碩士<br>國立暨南國際大學<br>應用化學系<br>104<br>The application of asymmetric aza-Michael addition reactions by utilizing organic catalyst is one of the important synthesis methods to create a carbon-nitrogen bond. And it is useful for nature product and medicine synthesis. It has economic benefits and is environmentaly friendly in asymmetric synthesis. In this thesis, aza-Michael addition reaction’s product is 1,3-oxazolidine. 1,3-Oxazolidines are important structural moieties that exist in many biologically active compound. For example, quinocarcin and its analogue terazomine are polycyclic tetrahydroisoq

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33

呂美瑩. "Palladium(II) mediated cyclization of ω-unsaturated α-cyano ketone－A facile method for the preparation of bridged ring systems". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/42044877180569357527.

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碩士<br>國立清華大學<br>化學系<br>91<br>This thesis describes the application of a palladium(II) acetate mediated annulation reaction recently discovered in our laboratories toward the construction of bridged systems bearing an exocyclic carbon-carbon double. A series of cyclic α-cyano ketones bearing a suitably positioned tethered terminal carbon-carbon double bond (i.e. 86, 88, and 97) were readily synthesized from commercially available starting materials and, upon treatment with palladium(II) acetate, gave the bridged bicyclic products 120, 122, and 124, respectively. Interestingly, α-cynoketone 114,

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34

Jinn-Kwei, Liang, та 梁晉魁. "The Reductive Decyanation of γ-Cyano-α,β-unsaturated Ketone and its Application to the Synthesis of spiro Compounds and 1,3-Diene Phosphates". Thesis, 2002. http://ndltd.ncl.edu.tw/handle/44756949153294065554.

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碩士<br>國立清華大學<br>化學系<br>90<br>Sequential treatment of bicyclic γ-cyano-α,β-unsaturated ketone 2, readily achieved by Robinson annulation of α-cyano ketone 1 with lithium naphthalenide (LN) and 1,4-diiodobutane or 1,5-diiodopentane gave, in one pot, spiro product 3 in a highly regioselective manner. The dienolate intermediate of the above reductive decyanation process could also be trapped with diethyl chlorophosphonate to give dienyl phosphate 4. Under Lewis acid catalysis conditions, treatment of phosphate 4 with dienophiles gave the highly functionalized Diels-Alder adduct such as compound 5.

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35

Sheu, Tzyy-Rong, and 許子榮. "(1)Syntheses of -deuterated- , -unsaturated carbonyl compounds by reaction of Aldehyde with stable phosphonium ylide in deuterium oxide(2)Microwave accelated -methylenation of ketone." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/95957739606207478871.

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碩士<br>國立中正大學<br>化學研究所<br>85<br>(一)利用穩定的鏻偶極體在重水中其α-氫會進行H-D交換的特性，我們可以將穩定的鏻偶極體置於重水-四氫喃的混合溶液中，在室溫下攪拌40 分鐘後加入醛類進行Wittig reaction，就可以合成含氘烯類化合物。使用這個中性溫和的合成方法，我們成功的合成出具多類型官能基的含氘烯類化合物，經由氫核磁共振光譜、質譜、元素分析的測定，其含氘百分比都相當高(>98%)。(二)過去本實驗室曾經使用CH2Br2-Et2NH的混合試劑跟醛類作用，進行α-亞甲基化反應，並得到很好的結果，不過這個試劑與酮類的反應卻需要很長的時間，由於許多類型的反應若使用微波照射可以大大地縮短反應時間，所以我們便將原本使用油浴加熱的反應改為微波照射，使得酮類與CH2Br2-Et2NH作用進行α-亞甲基化反應的速率平均提昇了約300倍，大幅縮短了反應時間。 (一)The α-H of stable Phosphon

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36

Tai, Chia-Liang, and 戴嘉良. "An Improved Robinson Annelation Process via Reductive Alkylation of the g-Cyano a,b-Unsaturated Ketone System and the Application to the Formal Synthesis of Nanaimoal." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/25117836902127827711.

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碩士<br>國立清華大學<br>化學系<br>87<br>This thesis describes a modified Robinson annelation process, which facilitates the preparation of a,a-disubstituted b,g-unsaturated ketones of general type 19 with complete regiocontrol, and the application of this modification to the synthesis of the marine natural product nanaimoal (33). The modified Robinson annelation makes use of the lithium naphthalenide induced reductive alkylation of g-cyano a,b-unsaturated ketones 18 as the key step. This type of cyano enones can be readily prepared from the corresponding a-cyano ketones 17 using the conventional Robins

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37

Chan, Yu-Hui, та 詹育惠. "Studies on the Palladium(0)-Catalyzed Intramolecular Amino-Heck Cyclization of γ,δ- Unsaturated Ketone O-Phosphinyloximes: A New Approach for the Preparation of Aza-heterocyclic Compounds". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/hqdjj8.

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碩士<br>國立東華大學<br>化學系<br>96<br>The palladium-catalyzed intramolecular amino Heck-type cyclization of unsaturated ketone oxime derivatives has been recognized as a powerful means for the preparation of aza-heterocycles. In this thesis, we describe a new protocol for this operation by utilizing the γ,δ-unsaturated ketone O-diethylphosphinyloximes as a novel type of substrates. These compounds can be readily prepared from the corresponding aldehydes or ketones. A series of γ,δ-unsaturated ketone O-diethylphosphinyloximes (21) was initially examined. Under the specific catalytic conditions developed

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38

Lin, Mei-Chun, and 林美君. "Lewis Acid-Promoted Michael Additions of a,b-Unsaturated Ketones with Mild Nucleophiles." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/22350457808852816703.

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碩士<br>淡江大學<br>化學學系<br>90<br>Abstract：a,b-Unsaturated carbonyl compound plays an important role in organic chemistry. The reaction products of a,b-unsaturated carbonyl compounds to either nucleophiles or electrophiles under reaction conditions have made them ideal precursors for organic synthesis and numerous natural products. The development of novel synthetic method leading to b-substituted carbonyl compound has received much attention in organic synthesis. The b-substituted carbonyl compound is an important intermediate for organic synthesis and an attractive target for natural products. Th

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39

Wen-ChunHou та 侯妏汮. "Theoretical studies of the amine-catalyzed self Diels-Alder reactions of α、β-unsaturated ketones". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/e6294b.

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碩士<br>國立成功大學<br>化學系碩博士班<br>101<br>In the course of understanding Diels-Alder (DA) reaction mechanism, the global electrophiliciy and empirical nucleophilicity defined within the density functional theory (DFT) have been adopted as reaction indices to account for the relative activation energies found experimentally. These published results are accomplished by DA reactions of a specified diene with substituted ethylene series. One general rule can be summarized by the statement that the increase of the electron-deficiency character of the dienophile, together with the increase of the electron-r

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40

"In vitro studies using curcumin and curcumin analogues as candidate mitochondria-targeting anticancer agents affecting colon cancer cells." Thesis, 2014. http://hdl.handle.net/10388/ETD-2014-09-1714.

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Curcumin is one of the major curcuminoids produced by the ginger family Zingiberaceae. These curcuminoids possess pharmacological properties that include anticancer activities. We have evaluated some synthetic curcumin analogues that have shown potential as anticancer drugs. These antineoplastic agents bearing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore are electrophiles which are designed to preferentially react with sulfhydryl groups present in proteins as opposed to amino and hydroxyl groups present in DNA. In previous pilot studies, three derivatives examined in this thesis showed i

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Zhu, Yen-Ruei, та 朱彥睿. "Catalyst-Free Synthesis of 1,5-Benzodiazepines by Cyclocondensation of β,γ-Unsaturated Ketones with o-Phenylenediamine". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/5a793c.

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碩士<br>淡江大學<br>化學學系碩士班<br>102<br>The benzodiazepines have attracted much attentions as pharmacophoric scaffold of heterocycles with a wide range of biological applications. These compounds are served as potentially biological compound with antianxiety, anti-depress, anti-inflammatory, anti-viral, anti-HIVand anti-microbial activities.Many synthetic methods for benzodiazepines have been reported,and mostly with the introduction of catalyst. We developed a novel catalyst-free method synthetic of 1,5-benzodiazepines which was obtained under sonochemical Barbier-type reaction conditions. A reat

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li-hsiang, Cheng, та 鄭禮翔. "Synthesis of chromanol derivatives from α,β-unsaturated ketones and aliphatic aldehydes via Michael addition reaction". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/45954819004561384470.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>This thesis describes the synthesis of benzoyl-substituted chromanol derivatives from α,β-unsaturated ketones and aliphatic aldehydes via Michael addition reaction. These derivatives appear as interesting intermediates in the synthesis of various natural products and biologically active compounds. Different types of α,β-unsaturated ketones (57,63) were allowed to react with aliphatic aldehyde to obtain the same products 64aa and 64ab. It’s worth mentioning that starting from either 57 or 63 as starting material, the diastereo orientation of products were differ

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Kafal, Adam. "Synthesis of Cyclic α,β-unsaturated Ketones via a Divergent Aldehyde Allylation and Ring-closing Metathesis Method". Thesis, 2011. http://hdl.handle.net/1807/29573.

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Montmorillonite-catalyzed allylation of aldehydes with potassium allyltrifluoroborate is a convenient method for the synthesis of homoallylic alcohols. This chemistry was applied to various unsaturated aldehydes, and the homoallylic alcohols produced were used as common intermediates for two separate but related synthetic routes to α,β-unsaturated ketones. In the first route, oxidation of the alcohol to the ketone was followed by base-catalyzed isomerization of the olefin to the α,β-unsaturated ketone. This was subjected to ring closing metathesis conditions to afford the cyclic enone of ring

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Lai, Yi-Chun, та 賴奕君. "The Application of α-Cyano-α,β-unsaturated Ketones as Congested Enone Equivalents in Diels-Alder Reaction". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/10186976394769591855.

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碩士<br>國立清華大學<br>化學系<br>95<br>English Abstract Construction of cyclohexane adducts via Diels-Alder reaction is an important issue in synthesis of natural products. This thesis describes an organic chemistry methodology development which is a novel process for the construction of highly congested cyclohexanes. The α-cyano-α,β- unsaturated ketones 19 and 22 can readily be prepared from the substituted acetonitriles 18 and ketones or aldehydes via a Knoevenagel condensation process. As we chose α-cyano-α,β-unsaturated ketone 19 as a dienophile, the Diels-Alder reaction with isoprene gave cyclohexa

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Fenster, Erik. "Conformationally controlled reactions of unsaturated macrocyclic lactones and keto lactones." Thesis, 2000. http://hdl.handle.net/2429/10608.

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As part of a study of the chemistry of macrocyclic compounds in our laboratory, the 14-membered unsaturated lactones 29 and 30 were synthesized with high stereoselectivity (>16:1 EIZ) via the ring closing olefin metathesis (RCM) reaction of the open chain diene esters. The configuration of the double bond in these unsaturated lactones was determined by 1H homonuclear decoupling NMR experiments. Equilibrium studies demonstrated that the RCM reaction proceeds under thermodynamic control in the cases of 29 and 30. The keto lactones 67 and 68 were synthesized via the hydroboration of 30 fol

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Lee, Su-lin, та 李士霖. "I. Structural Modification and Activity of Natural COX-2Inhibitors;II. Oxidation of α,β-Unsaturated Ketones withHypervalent Iodine Reagent". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/82037413237753139505.

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碩士<br>國立臺灣大學<br>藥學研究所<br>92<br>This thesis contains two parts entitled as following: I. Structural Modification and Activity of Natural COX-2 Inhibitors II. Oxidation of α,β-Unsaturated Ketones with Hypervalent Iodine Reagent I. Structural Modification and Activity of Natural COX-2 Inhibitors Although the NSAID are the most widely used and prescribed drugs world-wide for the treatment of inflammation, problems still remained concerning their tolerability, in particular, gastrointestinal irritation. The latter symptom is caused by the nonselective inhibition of both cyclooxygenases, COX-1 and

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Warad, Ismail Khalil [Verfasser]. "Diamine(phosphine)ruthenium(II) complexes and their application in the catalytic hydrogenation of α,β-unsaturated [alpha, beta-unsaturated] ketones in homogeneous and heterogeneous phase = Diamin(phosphin)ruthenium(II)-Komplexe und ihre Anwendung in der katalytischen Hydrierung von α,β-ungesättigten Ketonen in homogener und heterogener Phase / vorgelegt von Ismail Khalil Warad". 2003. http://d-nb.info/968855148/34.

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Chan, Sin Hang. "Asymmetric Conjugate Addition of Boronates to N-Acylimines and β-Silyl-α,β-unsaturated Ketones Catalyzed by 3,3'-Disubstituted Binaphthols". Thesis, 2009. http://hdl.handle.net/10012/4245.

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In order to extend the scope of asymmetric conjugate alkenylation catalyzed by 3,3′-disubstituted binaphthols, two classes of compounds were examined. Asymmetric 1,4-addition of alkenylboronates onto N-acylimines was investigated. Chiral allylic amides were obtained in good yields and high enantioselectivities. This represents one of the very few methods for synthesizing chiral allylic amides without the use of transition metal catalysts. Chiral binaphthol-catalyzed conjugate addition of alkenylboronates to -silyl--unsaturated ketones afforded highly enantioenriched chiral -silylcarbonyl

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Hsieh, Wan-Ping, та 謝琬萍. "(一) Reductive Alkylation of γ-Cyano-α,β-Unsaturated Ketones (二) Synthesis and Stereochemical Determination of 3-Amino-1,5-Hexadienes". Thesis, 2001. http://ndltd.ncl.edu.tw/handle/56391422721704046774.

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碩士<br>國立清華大學<br>化學系<br>89<br>The first project described in this thesis is the investigation of the rductive alkylation of γ-cyano-α,β-unsaturated enones 58 and 59 by sequential treatment with lithium naphthalenide and an alkylating agent. The reduction precursors 58 and 59 were individually synthesized starting with the Thorpe-Ziegler condensation of pimelonitrile and suberonitrile followed by acid hydrolysis of the ensuing cyano enamines. α-Cyano ketones 52 and 53 thus obtained separately were alkylated with allyl bromide in the presence of lithium hydride to give ketones 54 and 55 which we

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Huang, Sheng-Ran, та 黃聖然. "Toxicity Assessment and The Quantitative Structure -Acitivity Relationships of α,β-unsaturated Ketones based on the Effects on Pseudokirchneriella subcapitata". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/03497772326142908796.

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碩士<br>國立交通大學<br>環境工程系所<br>99<br>The objective of this study is to understand the toxic effect of ketones (that contains sixteen α,β-unsaturated ketones and two saturated ketones ) on Pseudokirchneriella subcapitata using a closed system test. The effects of ketones are evaluated by three kinds of response endpoints, i.e., final yield, growth rate, and the dissolved oxygen production. Median effective concentrations (EC50) are estimated using the Probit model with a test duration of 48hrs. Then, log (1/EC50) is utilized to make a regression with physical chemistry descriptors, electronic descri

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