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Journal articles on the topic 'UPLC-TOF-MS'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Patel, Prinesh N., D. Rajesh Kumar, S. Gananadhamu, and R. Srinivas. "Characterization of the stress degradation products of tolvaptan by UPLC-Q-TOF-MS/MS." RSC Advances 5, no. 27 (2015): 21142–52. http://dx.doi.org/10.1039/c4ra16644b.

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TVT was subjected to forced degradation under hydrolysis, oxidation, dry heat and photolysis conditions and the degradation products (DPs) formed have been characterized through UPLC-PDA and UPLC-Q-TOF-MS/MS studies.

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2

Zhao, Xiangsheng, Liwei Xie, Haifeng Wu, Weijun Kong, and Meihua Yang. "Analysis of six bioactive components in Semen Ziziphi Spinosae by UPLC-ELSD and UPLC-Q/TOF-MS." Anal. Methods 6, no. 15 (2014): 5856–64. http://dx.doi.org/10.1039/c4ay00800f.

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3

Liu, Yijun, Min Chen, Yimin Li, Xingqin Feng, Yunlan Chen, and Lijing Lin. "Analysis of Lipids in Green Coffee by Ultra-Performance Liquid Chromatography–Time-of-Flight Tandem Mass Spectrometry." Molecules 27, no. 16 (2022): 5271. http://dx.doi.org/10.3390/molecules27165271.

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Lipid components in green coffee were clarified to provide essential data support for green coffee processing. The types, components, and relative contents of lipids in green coffee were first analyzed by ultra-performance liquid chromatography–time-of-flight tandem mass spectrometry (UPLC-TOF-MS/MS). The results showed that the main fatty acids in green coffee were linoleic acid (43.39%), palmitic acid (36.57%), oleic acid (8.22%), and stearic acid (7.37%). Proportionally, the ratio of saturated fatty acids/unsaturated fatty acids/polyunsaturated fatty acids was close to 5.5:1:5.2. A total of

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4

Hayward, Douglas G., Jon W. Wong, Kai Zhang, et al. "Multiresidue Pesticide Analysis in Ginseng and Spinach by Nontargeted and Targeted Screening Procedures." Journal of AOAC INTERNATIONAL 94, no. 6 (2011): 1741–51. http://dx.doi.org/10.5740/jaoacint.sgehayward.

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Abstract Five different mass spectrometers interfaced to GC or LC were evaluated for their application to targeted and nontargeted screening of pesticides in two foods, spinach and ginseng. The five MS systems were capillary GC/MS/MS, GC-high resolution time-of-flight (GC/HR-TOF)-MS, TOF-MS interfaced with a comprehensive multidimensional GC (GCxGC/TOF-MS), an MS/MS ion trap hybrid mass (qTrap) system interfaced with an ultra-performance liquid chromatograph (UPLC-qTrap), and UPLC interfaced to an orbital trap high resolution mass spectrometer (UPLC/Orbitrap HR-MS). Each MS system was tested w

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5

Avula, Bharathi, Yan-Hong Wang, Troy J. Smillie, and Ikhlas A. Khan. "Column Liquid Chromatography/Electrospray Ionization-Time of Flight-Mass Spectrometry and Ultraperformance Column Liquid Chromatography/Mass Spectrometry Methods for the Determination of Ginkgolides and Bilobalide in the Leaves of Ginkgo biloba and Dietary Supplements." Journal of AOAC INTERNATIONAL 92, no. 2 (2009): 645–52. http://dx.doi.org/10.1093/jaoac/92.2.645.

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Abstract Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry (LC/ESI-TOF-MS) and ultraperformance column liquid chromatographic/MS (UPLC/MS) methods were developed for the determination of 5 terpenelactones in the leaves of Ginkgo biloba. The separation was performed using a C18 column and a mobile phase composed of water and acetonitrile. The limit of detection (LOD) values for ginkgolide J, ginkgolide C, ginkgolide B, and ginkgolide A were found to be in the range of 110 ng/mL by both methods, and the bilobalide LOD was 200 ng/mL by LC/ESI-TOF and 35 ng/mL b

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6

Wu, Hongyu, Feng Feng, Xiunan Jiang, et al. "Pharmacokinetic and metabolic profiling studies of sennoside B by UPLC-MS/MS and UPLC-Q-TOF-MS." Journal of Pharmaceutical and Biomedical Analysis 179 (February 2020): 112938. http://dx.doi.org/10.1016/j.jpba.2019.112938.

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7

Wang, Guanghou, Hongjin Wang, Huan Liu, Yue Wang, Ziwei Lin, and Lixin Sun. "The rapid profiling and simultaneous determination of 12 major alkaloids in Nauclea officinalis by UPLC-Q-TOF-MS and HPLC-ESI-MS/MS." Analytical Methods 13, no. 47 (2021): 5787–803. http://dx.doi.org/10.1039/d1ay01571k.

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For the first time, we determined the phytochemical profile of alkaloids from N. officinalis using ultraperformance liquid chromatography-quadrupole-time-of-flight-tandem mass spectrometry (UPLC-Q-TOF-MS/MS).

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8

Rui, Wen, Hongyuan Chen, Yuzhi Tan, Yanmei Zhong, and Yifan Feng. "Rapid Analysis of the Main Components of the Total Glycosides of Ranunculus japonicus by UPLC/Q-TOF-MS." Natural Product Communications 5, no. 5 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500521.

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A rapid method for the analysis of the main components of the total glycosides of Ranunculus japonicus (TGOR) was developed using ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS). The separation analysis was performed on a Waters Acquity UPLC system and the accurate mass of molecules and their fragment ions were determined by Q-TOF MS. Twenty compounds, including lactone glycosides, flavonoid glycosides and flavonoid aglycones, were identified and tentatively deduced on the basis of their elemental compositions, MS/MS data and relevant li

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9

Jin, Yiran, Tingting Tian, Yinghua Ma, et al. "Chemical profiling and total quality assessment of Isodon japonica using data-independent acquisition mode combined with superimposed multiple product ion UHPLC-Q-TOF-MS and chemometric analysis." RSC Advances 9, no. 3 (2019): 1403–18. http://dx.doi.org/10.1039/c8ra08732f.

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10

Xue, Ying, Wei Jin, Xian-Shun Xu, et al. "Quality Evaluation of Tricholoma matsutake based on the Nucleic Acid Compounds by UPLC-TOF/MS and UPLC-QqQ/MS." Molecules 24, no. 1 (2018): 34. http://dx.doi.org/10.3390/molecules24010034.

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So far, there has been no quality evaluation of Tricholoma matsutake. Nucleic acid compounds are a kind of functional ingredient in T. matsutake that is beneficial to human health. In this study, a UPLC-TOF/MS method was first used to scan and identify the potential nucleic acid compounds in T. matsutake. Based on the calculation of the molecular formula and subsequent confirmation by authentic standards, 15 nucleic acid compounds were unambiguously identified: adenosine, cytidine, guanosine, inosine, thymidine, uridine, xanthosine dehydrate, 2′-deoxyadenosine, 2′-deoxycytidine, 2′-deoxyguanos

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11

Jia, Wenjing, Qimao Bi, Sirong Jiang, et al. "Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS." Food & Function 13, no. 5 (2022): 2456–64. http://dx.doi.org/10.1039/d1fo03761g.

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Firstly confirmed the a-glucosidase inhibitory effects of Codonopsis pilosula (Franch.) Nannf. in vivo and in vitro. 29 ingredients in this plant were detected and identified by UPLC-Triple-TOF-MS/MS.

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12

Yang, Shenshen, Meng Tian, Lei Yuan, et al. "Analysis ofE. rutaecarpaAlkaloids ConstituentsIn VitroandIn Vivoby UPLC-Q-TOF-MS Combined with Diagnostic Fragment." Journal of Analytical Methods in Chemistry 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/4218967.

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Evodia rutaecarpa(Juss.) Benth. (Rutaceae) dried ripe fruit is used for dispelling colds, soothing liver, and analgesia. Pharmacological research has proved that alkaloids are the main active ingredients ofE. rutaecarpa. This study aimed to rapidly classify and identify the alkaloids constituents ofE. rutaecarpaby using UPLC-Q-TOF-MS coupled with diagnostic fragments. Furthermore, the effects of the material base ofE. rutaecarpabioactive ingredientsin vivowere examined such that the transitional components in the blood of rats intragastrically givenE. rutaecarpawere analyzed and identified. In

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13

Wang, Yanyan, Shan He, Xiaochen Cheng, Yuxin Lu, Yunpeng Zou, and Qinglin Zhang. "UPLC–Q-TOF-MS/MS fingerprinting of Traditional Chinese Formula SiJunZiTang." Journal of Pharmaceutical and Biomedical Analysis 80 (June 2013): 24–33. http://dx.doi.org/10.1016/j.jpba.2013.02.021.

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14

Zhang, Jie, Le Qian, Chen Wang, et al. "UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat." Environmental Pollution 266 (November 2020): 115310. http://dx.doi.org/10.1016/j.envpol.2020.115310.

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15

Shi, Zhong Feng, Yi Fan Feng, Wen Rui, Liang Wang, Xiao Mei Zhang, and Liang Han. "Rapid Analysis of the Main Components of Glycyrrhizae Uralensis Fisch by UPLC/Q-TOF-MS." Advanced Materials Research 581-582 (October 2012): 269–72. http://dx.doi.org/10.4028/www.scientific.net/amr.581-582.269.

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A rapid method for analysis of the main components of Radix Glycyrrhizae (RG) was developed using ultra-performanceliquid chromatography with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS). Previous study demonstrated that RG had antivirus, antioxidant，anti-tumor and other bioactivities. The separation analysis was performed on Waters Acquity UPLC system and the accurate mass of molecules and their fragment ions were determined by Q-TOF MS. Fourty compounds including triterpenoid saponins, flavonoid glycosides and flavonoid aglycones,coumarins, were identified and tentatively dedu

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16

Alasvand, Sepideh, Hyun-Jin Kim, and Vivian Haley-Zitlin. "UPLC-QTOF-MS Method for Identification of Mango Leaf Tea Metabolites." Current Developments in Nutrition 4, Supplement_2 (2020): 1736. http://dx.doi.org/10.1093/cdn/nzaa065_001.

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Abstract Objectives The study aim was to identify bioactive compounds in mango leaf tea using a new method - UPLC/Q-TOF-MS. Mango leaf tea is a natural product being investigated to manage type 2 diabetes due to its phytochemical properties. Methods Mango tea was extracted using 80% methanol overnight. The extract was analyzed with ultra-high-performance liquid chromatography-quadrupole time-of-flight (UPLC-Q-TOF) MS system (Waters Corp., Milford, MA) and injected into an Acquity UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 µm, Waters Corp.). The column was equilibrated with distilled water conta

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17

Yang, Ying, Xi Juan Zhao, Yu Pan, and Zhiqin Zhou. "Identification of the chemical compositions of Ponkan peel by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry." Analytical Methods 8, no. 4 (2016): 893–903. http://dx.doi.org/10.1039/c5ay02633d.

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18

Zhang, Hongye, Hua Zheng, Gan Zhao, et al. "Metabolomic study of corticosterone-induced cytotoxicity in PC12 cells by ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry." Molecular BioSystems 12, no. 3 (2016): 902–13. http://dx.doi.org/10.1039/c5mb00642b.

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19

Xue, Ying, Lin-Sen Qing, Li Yong, et al. "Determination of Flavonoid Glycosides by UPLC-MS to Authenticate Commercial Lemonade." Molecules 24, no. 16 (2019): 3016. http://dx.doi.org/10.3390/molecules24163016.

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So far, there is no report on the quality evaluation of lemonade available in the market. In this study, a sample preparation method was developed for the determination of flavonoid glycosides by ultra-performance liquid chromatography–mass spectrometry (UPLC-MS) based on vortex-assisted dispersive liquid-liquid microextraction. First, potential flavonoids in lemonade were scanned and identified by ultra-performance liquid chromatography–time of flight mass spectrometry (UPLC-TOF/MS). Five flavonoid glycosides were identified as eriocitrin, narirutin, hesperidin, rutin, and diosmin according t

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20

Ren, Zhihui, Xiaoxi Zhang, Haiyuan Wang, and Xinghua Jin. "Using an innovative quality-by-design approach for the development of a stability-indicating UPLC/Q-TOF-ESI-MS/MS method for stressed degradation products of imatinib mesylate." RSC Advances 6, no. 16 (2016): 13050–62. http://dx.doi.org/10.1039/c5ra26456a.

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Chromatography modeling softwares (DryLab®2000 plus and Design Expert®8.0.6) were used to develop a stability indicating UPLC/Q-TOF-ESI-MS/MS method for the simultaneous determination of stressed degradation products of imatinib mesylate.

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21

Ning, Zi-wan, Li-xiang Zhai, Tao Huang та ін. "Identification of α-glucosidase inhibitors from cyclocarya paliurus tea leaves using UF-UPLC-Q/TOF-MS/MS and molecular docking". Food & Function 10, № 4 (2019): 1893–902. http://dx.doi.org/10.1039/c8fo01845f.

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11 potential α-glucosidase inhibitors in leaves of Cyclocarya paliurus were quickly identified by UF-UPLC-Q/TOF-MS/MS, and their inhibitory activities were verified in vitro and in vivo, as well as docked with homology model.

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22

Chen, Wei-hong, Zhen Luo, Zi-Wan Ning, et al. "Rapid identification of direct-acting pancreatic protectants from Cyclocarya paliurus leaves tea by the method of serum pharmacochemistry combined with target cell extraction." Open Chemistry 18, no. 1 (2020): 265–74. http://dx.doi.org/10.1515/chem-2020-0032.

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AbstractExtracts of Cyclocarya paliurus (CP) leaves, a popular sweet tea, inhibit pancreatic β cell apoptosis and have potent hypoglycemic effects, but the identities of the anti-apoptotic bioactive components are still unknown. In the present study, a method using UPLC-Q-TOF/MS based on serum pharmacochemistry combined with target cell extraction was established to rapidly identify direct-acting pancreatic protectants from CP. After orally administering a set amount of CP extract to rats, blood samples were collected to characterize the components that can be absorbed into the blood using UPL

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23

Ma, Junmei, Qiang Li, Sufang Fan, et al. "Determination of 8 Endogenous Alkaloid Components in Boletus Using Ultrahigh-Performance Liquid Chromatography Combined with Quadrupole-Time of Flight Mass Spectrometry." Journal of Food Quality 2020 (September 24, 2020): 1–10. http://dx.doi.org/10.1155/2020/8865725.

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A ultrahigh performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UPLC-Q-TOF/MS) method was developed for simultaneous determination of 8 endogenous alkaloid compounds in Boletus. Boletus samples were extracted by 50% (V/V) methanol-water solution, then separated by CORTECS UPLC HILIC column using a binary solvent system by gradient elution. The analytes were determined by Q-TOF/MS in TOF MS and information dependent acquisition (IDA)-MS/MS mode. The results showed that mass accuracy error of the 8 endogenous alkaloids were lower than 5.0 × 10−6, good line

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24

Yuan, Lei, Jia Yin, Meng Tian, et al. "The classification and identification of complex chemical compositions in yanhusuo herb using UPLC-Q-TOF/MS." Analytical Methods 8, no. 10 (2016): 2274–81. http://dx.doi.org/10.1039/c5ay03162a.

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25

Wang, Dongxu, Qi Wang, Renhao Chen, Shinlin Yang, Zhifeng Li, and Yulin Feng. "Exploring the effects of Gastrodia elata Blume on the treatment of cerebral ischemia-reperfusion injury using UPLC-Q/TOF-MS-based plasma metabolomics." Food & Function 10, no. 11 (2019): 7204–15. http://dx.doi.org/10.1039/c9fo01729a.

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26

Liu, Mengting, Zhiqin Liu, Zhuang Dong, Xianglin Zou, Jianguo Zeng, and Zihui Yang. "Identification of Sanguinarine Metabolites in Rats Using UPLC-Q-TOF-MS/MS." Molecules 28, no. 22 (2023): 7641. http://dx.doi.org/10.3390/molecules28227641.

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Sanguinarine (SAN), as the main active component of a traditional Chinese veterinary medicine, has been widely used in the animal husbandry and breeding industry. However, the metabolites of SA are still uncertain. Therefore, this research aimed to investigate the metabolites of SA based on rats in vivo. The blood, feces, and urine of rats were collected after the oral administration of 40 mg/kg SAN. Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) was employed to identify the metabolites of SAN. The elemental composition

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27

Rosano, Thomas G., Patrice Y. Ohouo, and Michelle Wood. "Application of High-Resolution UPLC–MSE/TOF Confirmation in Forensic Urine Drug Screening by UPLC–MS/MS." Journal of Analytical Toxicology 43, no. 5 (2019): 353–63. http://dx.doi.org/10.1093/jat/bky106.

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28

Zhong, Zhijian, Pan Deng, Xiaorong Luo, et al. "Multi-Component Characterization and Quality Evaluation Strategy of Sarcandrae Herba by Combining Dual-Column Tandem HPLC Fingerprint and UPLC-Q-TOF-MS/MS." Molecules 30, no. 8 (2025): 1825. https://doi.org/10.3390/molecules30081825.

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A dual-column tandem mode was used to establish the fingerprints of Sarcandrae herb from different origins, and their chemical compositions were characterized by UPLC-Q-TOF-MS/MS, which provided an experimental basis for the establishment of a rapid and efficient method for the overall quality control of Sarcandrae herba. For the first time, nine common components were identified from the Sarcandrae herba herbs of 24 origins, which were neochlorogenic acid, chlorogenic acid, 4-caffeoylquinic acid, eleutheroside B1, quercetin-3-O-β-D-glucuronide, neoastilbin, astilbin, isofraxidin, and rosmarin

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29

Minohara, Sawa, Masaya Fujishiro, Xiao-Pen Lee, et al. "High-throughput identification and determination of aminoglycoside antibiotics in human plasma using UPLC–Q-ToF-MS." European Journal of Mass Spectrometry 27, no. 1 (2021): 63–70. http://dx.doi.org/10.1177/14690667211003196.

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Aminoglycosides are a class of broad-spectrum antibiotics with several clinical uses. Owing to the ototoxicity and nephrotoxicity of aminoglycosides, therapeutic drug monitoring is required. This study aimed to devise a high-throughput method for identification and quantitative determination of aminoglycoside antibiotics in human plasma samples using ultra-performance liquid chromatography–quadrupole time-of-flight-mass spectrometry (UPLC–Q-ToF-MS). Plasma samples (100 µL) spiked with five aminoglycosides (streptomycin, spectinomycin, amikacin, kanamycin, and gentamycin) and an internal standa

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30

Rui, Wen, Wanxia Xia, Wei Zhao, et al. "Differential Constituents in Roots, Stems and Leaves of Polygonum multiflorum Thunb. Screened by UPLC/ESI-Q-TOF-MS and Multivariate Statistical Analysis." Journal of Chromatographic Science 58, no. 2 (2019): 136–43. http://dx.doi.org/10.1093/chromsci/bmz086.

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Abstract The differential constituents in leaves, stems and roots of Polygonum multiflorum Thunb. were analyzed by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC/ESI-Q-TOF-MS) and by multivariate statistical analysis. The established extraction and analysis method showed relative standard deviations (RSDs) for intra-day precision of less than 3.40%, for repeatability of less than 4.06% and for stability of less than 5.10%. Principal component analysis and orthogonal projections to latent structures discriminant ana

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31

Wang, Meiling, Yuehong Liu, Shuang Fu, Qingqing Zhang, Qing Wang, and Xiaoyan Gao. "Applying target data screening followed by characteristic fragment filtering for the comprehensive screening and identification of alkaloids in Corydalis yanhusuo W. T. Wang by UPLC-Q-TOF/MSE." RSC Advances 7, no. 84 (2017): 53545–51. http://dx.doi.org/10.1039/c7ra08720a.

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A target data screening strategy followed by characteristic fragment filtering by UPLC-Q-TOF/MS<sup>E</sup> was developed for rapidly and comprehensively identifying alkaloids in Corydalis yanhusuo W. T. Wang (Yanhusuo).

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32

Jia, Fei, Tengfei Xu, Yao Qi, et al. "A study on the holistic efficacy of different Radix Aconiti Preparata for treating rheumatic arthritis in rats based on the urinary metabonomic method using UPLC-Q-TOF-HDMS." Analytical Methods 8, no. 15 (2016): 3088–95. http://dx.doi.org/10.1039/c6ay00260a.

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15 potential biomarkers related to the efficacy of RadixAconiti Preparatain adjuvant-induced arthritis rats had been identified by UPLC-Q-TOF-MS in urine, and they are mainly involved in four metabolic pathways.

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Liu, Wenrui, Feng Jin, Dan Gao, Lu Song, Chao Ding, and Hongxia Liu. "Metabolomics analysis reveals aminoquinazolin derivative 9d-induced oxidative stress and cell cycle arrest in A549 cells." RSC Advances 7, no. 22 (2017): 13149–58. http://dx.doi.org/10.1039/c7ra00185a.

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An UPLC/Q-TOF MS based metabolomics approach was established to study the probable antitumor mechanism of aminoquinazolin derivative 9d, which could induce oxidative stress and cell cycle arrest in A549 lung cancer cells.

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Dong, Song-Tao, Ying Li, Hao-Tian Yang, et al. "An Accurate and Effective Method for Measuring Osimertinib by UPLC-TOF-MS and Its Pharmacokinetic Study in Rats." Molecules 23, no. 11 (2018): 2894. http://dx.doi.org/10.3390/molecules23112894.

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Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors. In this research, an original analysis method was established for the quantification of osimertinib by ultra-performance liquid chromatography with time of flight mass spectrometry (UPLC-TOF-MS) in rat plasma. After protein precipitation with acetonitrile and sorafinib (internal standard, IS), they were chromatographed through a Waters XTerra MS C18 column. The mobile phase was acetonitrile and water (including 0.1% ammonia). The relative

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Yue, Huilan, Luya Wang, Sirong Jiang, et al. "Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS." Food & Function 13, no. 3 (2022): 1659–67. http://dx.doi.org/10.1039/d1fo03436g.

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The anti-hyperglycaemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba (RC) was firstly demonstrated in vivo and in vitro, and 40 ingredients in RC were detected and identified by UPLC-Triple-TOF-MS.

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Wang, Jiaqi, Wenyue Jiang, Zhongying Liu, Junhua Wang, Tianyue Fu, and Yongsheng Wang. "Analysis and identification of chemical constituents of fenugreek by UPLC-IT-MS n and UPLC-Q-TOF-MS." Chemical Research in Chinese Universities 33, no. 5 (2017): 721–30. http://dx.doi.org/10.1007/s40242-017-7136-4.

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37

Li, Jian, Junmei Ma, Yan Zhang, and Lei Zheng. "Determination of 4 psychoactive substances in tea using ultra high performance liquid chromatography combined with the quadrupole time-of-flight mass spectrometry." Analytical Methods 12, no. 40 (2020): 4878–84. http://dx.doi.org/10.1039/d0ay01535k.

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In this study, a method for the qualification and quantification of 4 psychoactive substances in tea using ultra high performance liquid chromatography coupled with the quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) has been developed.

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Li, He, Yu Song, Hongwei Zhang, et al. "Comparative lipid profile of four edible shellfishes by UPLC-Triple TOF-MS/MS." Food Chemistry 310 (April 2020): 125947. http://dx.doi.org/10.1016/j.foodchem.2019.125947.

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Shi, Yurui, Rongda Chen, Jing Xie, et al. "Determination and Pharmacokinetics of Okanin in Rat Plasma by UltraHigh Performance Liquid Chromatography Coupled with Triple-Quadrupole Tandem Mass Spectrometry." Journal of Analytical Methods in Chemistry 2020 (August 28, 2020): 1–7. http://dx.doi.org/10.1155/2020/4247128.

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Okanin is a major flavonoid found in Coreopsis tinctoria Nutt., arousing huge interest recently for its considerable biological characteristics including antioxidant, antineurotoxic, and antidiabetic activities. An ultrahigh performance liquid chromatography triple-quadrupole tandem mass spectrometry (UPLC-MS) was successfully used to determine okanin in rat plasma after oral administration of okanin. Bavachalcone acted as an internal standard (IS). By gradient elution, IS and analyte were separated on a C18 column for 7 min at a flow rate of 0.25 mL/min with acetonitrile-0.1% acetic acid mobi

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40

Wu, Yin, Pengqian Wang, Haotian Yang, and Feng Sui. "UPLC–Q‐TOF–MS and UPLC–MS/MS methods for metabolism profiles and pharmacokinetics of major compounds in Xuanmai Ganjie Granules." Biomedical Chromatography 33, no. 3 (2019): e4449. http://dx.doi.org/10.1002/bmc.4449.

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Liu, Guang-Da, Yi-Wu Zhao, Yan-Jing Li, et al. "Qualitative and quantitative analysis of major constituents from Dazhu Hongjingtian capsule by UPLC/Q-TOF-MS/MS combined with UPLC/QQQ-MS/MS." Biomedical Chromatography 31, no. 6 (2017): e3887. http://dx.doi.org/10.1002/bmc.3887.

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Shi, Dazhi, Mengyi Xu, Mengyue Ren та ін. "Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF-κB Signal Pathway in LPS-Stimulated RAW 264.7 Cells". Journal of Immunology Research 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/5476903.

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Objective. This study aimed to explore the immunoregulatory effect of flavonoids of blueberry (Vaccinium corymbosum L.) leaves (FBL). Methods. The flavonoids of blueberry leaves were prepared with 70% ethanol and were identified by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-Tof-MS). The immunoregulatory effect and possible regulatory mechanisms of FBL were investigated in lipopolysaccharide- (LPS-) induced RAW 264.7 cells. Results. According to the results of UPLC/Q-Tof-MS, nine flavonoids of blueberry leaves were identified. FBL showed a signifi

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Kim, Eun-Sook, Ji-Eon Jeong, Young-Hoi Kim, and Yong-Ouk You. "Effect of Cudrania tricuspidata on Cariogenic Properties and Caries-Related Gene Expression in Streptococcus mutans." Molecules 30, no. 8 (2025): 1755. https://doi.org/10.3390/molecules30081755.

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The purpose of this study was to evaluate the gene expression pattern of the caries-inhibiting effect of Cudrania tricuspidata (C. tricuspidata) extract on cariogenic bacteria Streptococcus mutans (S. mutans). We examined bacterial growth, tooth surface attachment, biofilm formation, acid production, free calcium release, and toxicity gene expression. The major components of the extract were investigated by UPLC-Q-TOF-MS analysis. Exposure to C. tricuspidata inhibited bacterial growth and attachment at concentrations of ≥15 μg/mL. Inhibition effects on biofilm formation, acid production, and f

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Zha, Xiaoyu, Gaowen Li, Ling Zhang, Qun Chen, and Qing Xia. "Identification of active compounds in Ophiopogonis Radix from different geographical origins by UPLC-Q/TOF-MS combined with GC-MS approaches." Open Life Sciences 17, no. 1 (2022): 865–80. http://dx.doi.org/10.1515/biol-2022-0096.

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Abstract Ophiopogonis Radix, also known as Maidong in Chinese, is largely produced in the Sichuan and Zhejiang provinces: “Chuan-maidong (CMD)” and “Zhe-maidong (ZMD),” respectively. This study aimed to distinguish and evaluate the quality of CMD and ZMD. In this study, the tubers of CMD and ZMD were investigated using UPLC-Q/TOF-MS, GC-MS, and LC-MS methods, respectively. Overall, steroidal saponins, homoisoflavonoids, amino acids, and nucleosides were quickly identified. Furthermore, multivariate statistical analysis revealed that CMD and ZMD could be separated. Moreover, CMD showed higher l

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Zhuang, Bo, Zhi-Ming Bi, Zi-Yuan Wang, Li Duan, Chang-Jiang-Sheng Lai, and E.-Hu Liu. "Chemical profiling and quantitation of bioactive compounds in Platycladi Cacumen by UPLC-Q-TOF-MS/MS and UPLC-DAD." Journal of Pharmaceutical and Biomedical Analysis 154 (May 2018): 207–15. http://dx.doi.org/10.1016/j.jpba.2018.03.005.

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Gu, Chunxiu, Yanling Cheng, Xin Zhen, Xiaoxuan Chen, and Kaowen Zhou. "Determination of Progestin Residues in Fish by UPLC-Q-TOF/MS Coupled with QuEChERS." Journal of Analytical Methods in Chemistry 2019 (May 2, 2019): 1–6. http://dx.doi.org/10.1155/2019/6426958.

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A novel method was developed for simultaneous determination of 10 progestin residues in fish by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) combined with a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. The homogenized samples were dispersed by water, extracted with acetonitrile, and then purified by QuEChERS reagent. The concentrated analytes were detected by UPLC-Q-TOF/MS. High linearities (R2 > 0.995) and recoveries (85.71–117.08%) at three spiked levels (5, 10, and 20 ng/g) and low relative standard dev

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Wang, Gang, Shun Yao, Xiu-Xiu Zhang, and Hang Song. "Rapid Screening and Structural Characterization of Antioxidants from the Extract ofSelaginella doederleiniiHieron with DPPH-UPLC-Q-TOF/MS Method." International Journal of Analytical Chemistry 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/849769.

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2,2-Diphenyl-1-picrylhydrazyl-ultra-high performance liquid chromatography-Q-time-of-flight mass spectrometry (DPPH-UPLC-Q-TOF/MS), as a rapid and efficient means, now was used for the first time to screen antioxidants fromSelaginella doederleinii. The nine biflavone compounds were screened as potential antioxidants. The biflavones were structurally identified and divided into the three types, that is, amentoflavone-type, robustaflavone-type, and hinokiflavone-type biflavonoids. Among the compounds bilobetin (3) and putraflavone (8) were found fromSelaginella doederleiniifor the first time and

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朱, 高峰. "Rapid Identification on Chemical Components in Lespedeza Cuneata by UPLC-Q-TOF-MS/MS." Hans Journal of Medicinal Chemistry 09, no. 02 (2021): 35–43. http://dx.doi.org/10.12677/hjmce.2021.92005.

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Lv, Yanhui, Xike Xu, Jishun Yang, et al. "Identification of chemical components and rat serum metabolites in Danggui Buxue decoction based on UPLC-Q-TOF-MS, the UNIFI platform and molecular networks." RSC Advances 13, no. 46 (2023): 32778–85. http://dx.doi.org/10.1039/d3ra04419j.

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The material basis of DBD was annotated using UPLC-Q-TOF-MS, UNIFI platform and molecular network. 207 chemical components were unambiguously or tentatively identified in DBD. A total of 29 prototypical constituents and 51 metabolites were identified in the serum of rats after DBD administration.

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Li, Limin, Bin Hao, Yulong Zhang, Shen Ji, and Guixin Chou. "Metabolite Profiling and Distribution of Militarine in Rats Using UPLC-Q-TOF-MS/MS." Molecules 25, no. 5 (2020): 1082. http://dx.doi.org/10.3390/molecules25051082.

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Militarine, a natural glucosyloxybenzyl 2-isobutylmalate, isolated from Bletilla striata, was reported with a prominent neuroprotective effect recently. The limited information on the metabolism of militarine impedes comprehension of its biological actions and pharmacology. This study aimed to investigate the metabolite profile and the distribution of militarine in vivo, which help to clarify the action mechanism further. A total of 71 metabolites (57 new metabolites) in rats were identified with a systematic method by ultra-high-performance liquid chromatography combined with quadrupole time-

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