Academic literature on the topic 'Urachal cancer'

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Journal articles on the topic "Urachal cancer"

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Lee, Seung Ryeol, Haeyoun Kang, Moon Hyung Kang, et al. "The Youngest Korean Case of Urachal Carcinoma." Case Reports in Urology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/707456.

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Urachal anomalies are relatively uncommon and result from incomplete obliteration of the urachus perinatally. In children, most urachal diseases including urachal cysts and sinuses are benign, and these can sometimes become secondarily infected. Malignant involvement of the urachus is rarely reported, one in 5 million people, accounting for 0.35% to 0.7% of all bladder cancers. There are only five cases of urachal cancer diagnosed at the age of twenties in English written literature. Age at the diagnosis of urachal carcinoma is important to understand pathogenetic transition from benign to mal
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Elser, Christine, Joan Sweet, Sendhil K. Cheran, Masoom A. Haider, Michael Jewett, and Srikala S. Sridhar. "A case of metastatic urachal adenocarcinoma treated with several." Canadian Urological Association Journal 6, no. 1 (2013): 27. http://dx.doi.org/10.5489/cuaj.336.

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Urachal cancer is a rare form of bladder cancer that arises fromthe urachus, a vestigial musculofibrous band that extends from thedome of the bladder to the umbilicus. Urachal cancer often presentsat an advanced stage and has a dismal prognosis. We presenta case of a young woman with urachal cancer that recurred rapidlypost-partial cystectomy. The patient was treated with up to 6 different chemotherapy regimens, including an oral antiangiogenic drug as part of a clinical trial. Our case illustrates the aggressive nature of this disease, the difficulty in accessing drugs for the treatment of ra
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Kumari, Ajitha, Mohan P. Sam, and Sany Philip. "An unusual case of painless hematuria - A rare case report and review of literature." Journal of Pathology of Nepal 13, no. 2 (2023): 2111–13. http://dx.doi.org/10.3126/jpn.v13i2.46584.

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Urachal carcinoma is a rare and aggressive cancer arising from a persistent urachus which is a remnant of the allantois that extends from blader to umblicus.This is a case report of urachal carcinoma in a 37 year old male who presented with gross painless hematuria . On radiological investigation he was found to have a tumor involving dome of bladder and urachal remnant. Cystoscoic biopsy suggested carcinoma. Partial cystectomy with enblock removal of urachus and umblicus was done. On cutting the specimen through umblicus the urachal remnant was identified very well with a tumor from distal ur
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Sah, Anjali, GS Triveni, and SH Chandrashekhara. "Case series of urachal adenocarcinoma: Imaging features." Journal of Cancer Research and Therapeutics 20, no. 3 (2023): 1057–60. http://dx.doi.org/10.4103/jcrt.jcrt_2382_21.

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ABSTRACT Urachal adenocarcinoma is an unusual and aggressive form of bladder cancer that arises from urachus, a midline fibrous remnant of allantois. Experience with diagnosing them is limited and differentiating urachal adenocarcinoma from other urachal pathologies like infected urachal cysts may be difficult at times. Differentials of urachal anomalies can be narrowed down by proper assessment of patient demographics, clinical details, lesion morphology, and imaging findings. With this case series of five patients of urachal adenocarcinoma, we have tried describing their clinical manifestati
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Nyushko, K. M., B. Ya Alekseev, A. S. Kalpinsky, and A. D. Kaprin. "Urachal cancer." Onkologiya. Zhurnal imeni P.A.Gertsena 4, no. 3 (2015): 43. http://dx.doi.org/10.17116/onkolog20154343-47.

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Fitzgerald, E., and M. Pirani. "Urachal cancer." British Journal of Radiology 58, no. 696 (1985): 1230. http://dx.doi.org/10.1259/0007-1285-58-696-1230.

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Bazaev, V. V., N. V. Bychkova, A. A. Morozov, A. P. Morozov, and Е. V. Smirnova. "Complications of urachal cyst: aspects of diagnosis and treatment in adult patients." Experimental and Сlinical Urology 13, no. 4 (2020): 114–19. http://dx.doi.org/10.29188/2222-8543-2020-13-4-114-119.

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Introduction. Urachal cyst is a congenital malformation, presented by a closed cavity filled with serous fluid in the urachus. Although a morphological picture of the urachal malformation is well known and is quite common in different patients, each case with a complicated cyst has unique clinical features, requiring a differential diagnosis. Aim. To demonstrate differential diagnosis of two cases with congenital urachal malformations, presenting different clinical features. Materials and methods. The study describes 2 clinical cases. A 65-year-old patient presented with non-intensive hematuri
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Sun, Maxine, Guillermo de Velasco, Christian P. Meyer, et al. "Urachal versus nonurachal adenocarcinomas of the bladder: A population-based report." Journal of Clinical Oncology 34, no. 2_suppl (2016): 450. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.450.

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450 Background: Previous studies are inconclusive on whether urachal vs. non-urachal adenocarcinomas of the urinary bladder have different prognoses. Our objective was to assess survival differences between urachal vs. non-urachal adenocarcinomas in light of evolving treatment strategies over the past years. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with a diagnosis of adenocarcinoma of the urinary bladder between years 1988 and 2012. The variable of interest was urachal vs. non-urachal adenocarcinomas. Kaplan-Meier curves and log-ra
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Ter-Ovanesov, M. D., D. M. Yagudaev, A. A. Gritskevich, A. V. Umyarova, and V. A. Bezhenar. "The organ sparing management of a patient with urachus cancer in conditions of comorbidity." Research and Practical Medicine Journal 11, no. 1 (2024): 70–77. http://dx.doi.org/10.17709/2410-1893-2024-11-1-6.

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Malignant tumors of the urachus are extremely rare. The frequency of urachal malignancy makes 1: 5 000 000 cases, which is 0.35–1.2 % of all the cases of bladder cancer. The small series of observations described in the literature do not allow us to formulate statistically reliable and unambiguously recommended statements about the optimal methods of diagnostics and treatment of this pathology. The diagnosis of urachus diseases is often challenging. This is associated with both the asymptomatic course and the variety of clinical flow of the disease. The treatment strategies are also largely am
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Kardos, Jordan, Sara E. Wobker, Michael E. Woods, et al. "Comprehensive Molecular Characterization of Urachal Adenocarcinoma Reveals Commonalities With Colorectal Cancer, Including a Hypermutable Phenotype." JCO Precision Oncology, no. 1 (November 2017): 1–12. http://dx.doi.org/10.1200/po.17.00027.

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Purpose Urachal adenocarcinoma is a rare type of primary bladder adenocarcinoma that comprises less than 1% of all bladder cancers. The low incidence of urachal adenocarcinomas does not allow for an evidence-based approach to therapy. Transcriptome profiling of urachal adenocarcinomas has not been previously reported. We hypothesized that an in-depth molecular understanding of urachal adenocarcinoma would uncover rational therapeutic strategies. Patients and Methods We performed targeted exon sequencing and global transcriptome profiling of 12 urachal tumors to generate a comprehensive molecul
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Dissertations / Theses on the topic "Urachal cancer"

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Galarza, Andrés Fernando Andrade. "Avaliação genotípica e fenotípica da enzima diidropirimidina desidrogenase (DPD) e risco de toxicidade com o uso de fluoropirimidinas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/143351.

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Base teórica: As fluoropirimidinas possuem significativa variabilidade na resposta terapêutica e na ocorrência de toxicidade, o que tem sido relacionado à deficiência na depuração metabólica mediada pela enzima diidropirimidina desidrogenase (DPD). Mutações nos genes codificadores da enzima, bem como fatores ambientais podem levar à baixa ou nula expressão enzimática, provocando efeitos adversos graves devido ao acúmulo destes fármacos. Até o presente, nenhum teste reconhecidamente valido para a identificação de indivíduos em risco de toxicidade severa está estabelecido na prática oncológica.
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Studebaker, Adam W. "Targeting uracil exclusion mechanisms for development of anti-viral and anti-cancer therapies." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1056034774.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 210 p.; also includes graphics (some col.). Includes bibliographical references (p. 174-210). Available online via OhioLINK's ETD Center
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Studebaker, Adam Wade. "Targteing uracil exclusion mechanisms for development of anti-viral and anti-cancer therapies." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1056034774.

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Guo, Chunguang. "Ugene, a Newly Identified Protein that is Commonly Over-Expressed in Cancer, and that Binds to Uracil DNA-Glycosylase." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1217422102.

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Yan, Yan. "Characterization of Uracil DNA Glycosylase as a Therapeutic Target for Sensitization of Floxuridine in Cancer with P53 Mutation or Deficiency." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1499644338014377.

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Hsuan-Yuan and 黃玄遠. "Comparing Oral Tegafur/Uracil (UFUR®) v.s. Intravenous Infusional 5-Fluorouracil in Preoperative Concurrent Chemoradiotherapy for Rectal Cancer." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/xr25ut.

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碩士<br>中山醫學大學<br>醫學研究所<br>100<br>Background:Surgical resection has been the main force of rectal cancer treatment. However, local recurrence has been the most challenge. Total mesorectal excision and concurrent chemo-radiotherapy can effectively reduce the local recurrence rate. Pre-operative concurrent chemo-radiotherapy is superior to post-operative concurrent chemo-radiotherapy in anal sphincter preservation and complete resection. UFUR is more convenient than infusion 5-FU. We compared oral uracil and tegafur plus leucovorin vs. infusion 5-fluorouracil plus leucovorin given concomitantly wi
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Huang, Hsuan-Yuan, and 黃玄遠. "Comparing Oral Tegafur/Uracil (UFUR®) v.s. Intravenous Infusional 5-Fluorouracil in Preoperative Concurrent Chemoradiotherapy for Rectal Cancer." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/qr68gu.

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碩士<br>中山醫學大學<br>醫學研究所<br>100<br>Background:Surgical resection has been the main force of rectal cancer treatment. However, local recurrence has been the most challenge. Total mesorectal excision and concurrent chemo-radiotherapy can effectively reduce the local recurrence rate. Pre-operative concurrent chemo-radiotherapy is superior to post-operative concurrent chemo-radiotherapy in anal sphincter preservation and complete resection. UFUR is more convenient than infusion 5-FU. We compared oral uracil and tegafur plus leucovorin vs. infusion 5-fluorouracil plus leucovorin given concomitantly wi
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Books on the topic "Urachal cancer"

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National Institute for Clinical Excellence. Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer. National Institute for Clinical Excellence, 2003.

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Sue, Ward, and National Co-ordinating Centre for HTA (Great Britain), eds. Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer: Systematic review and economic evaluation. Core Research on behalf of the NCCHTA, 2003.

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Mano, Roy, and Ofer Yossepowitch. Adenocarcinoma of the bladder. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0081.

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Adenocarcinoma of the bladder accounts for 0.5–2 of bladder tumours. Risk factors include bladder exstrophy, bladder augmentation, schistosomiasis, and endometriosis. Bladder adenocarcinoma is classified as primary, arising from the bladder or urachal remnant, and secondary (metastatic). Most patients present with haematuria and irritative voiding symptoms. On imaging, a typical lesion is commonly located at the bladder dome. Compared to urothelial carcinoma (UC), most adenocarcinomas are diagnosed at high grade and advanced stage. Surgical treatment of localized disease entails partial cystec
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Book chapters on the topic "Urachal cancer"

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Kumar, Priyadarshi, and Vinod H. Nargund. "Urachal and Urethral Cancer (Excluding Penile Cancer)." In Urological Oncology. Springer London, 2014. http://dx.doi.org/10.1007/978-0-85729-482-1_38.

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Aherne, G. Wynne, and Sherael Brown. "The Role of Uracil Misincorporation in Thymineless Death." In Antifolate Drugs in Cancer Therapy. Humana Press, 1999. http://dx.doi.org/10.1007/978-1-59259-725-3_20.

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Kavli, B., G. Slupphaug, and H. E. Krokan. "Chapter 10. Genomic Uracil in Biology, Immunity and Cancer." In DNA Damage, DNA Repair and Disease. Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839160769-00220.

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Krizanovic, O., and B. Lippert. "Bis(Uracil-)-Complexes of Cisplatin: Preparation, Protonation and Metal Binding." In Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1717-3_79.

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Nemoto, Hisao, Jianping Cai, and Yoshinori Yamamoto. "Synthesis of a Water-Soluble o-Carborane Bearing Uracil Moiety Via Palladium Catalyzed Reaction under Essentially Neutral Conditions." In Cancer Neutron Capture Therapy. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-9567-7_24.

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Schips, Luigi, and Richard Zigeuner. "Bladder Cancer." In Prognosis in Advanced Cancer. Oxford University PressOxford, 2008. http://dx.doi.org/10.1093/oso/9780198530220.003.0012.

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Abstract Bladder cancer is one of the most frequently diagnosed cancers in humans, the fourth most common cancer in males and the eighth most common cancer in females, which translates into male- to-female ratio of approximately 2.5:1.1 Histologically, the majority (more than 90 per cent) of cases are transitional cell carcinomas (TCCs). Rare cases include squamous cell carcinoma, especially caused by schistosomiasis in endemic regions and indwelling catheters, as well as adenocarcinomas, and urachal carcinoma.
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Sarno, Antonio, Pål Sætrom, Bodil Kavli, and Henrik Sahlin Pettersen. "Genomic Uracil and Cancer." In Genomic Uracil. WORLD SCIENTIFIC, 2018. http://dx.doi.org/10.1142/9789813233508_0007.

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Liu, Wenbin, and Guangwen Cao. "Hepatitis B Virus (HBV) - Induced Hepatocarcinogenesis, a Founding Framework of Cancer Evolution & Development (Cancer Evo-Dev)." In Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99838.

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In this chapter, we present the founding framework of a novel theory termed as Cancer Evolution-Development (Cancer Evo-Dev), based on the current understanding of hepatitis B virus (HBV) induced hepatocarcinogenesis. The interactions of genetic predispositions and HBV infection is responsible for the maintenance of chronic non-resolving inflammation. Under the inflammatory microenvironment, pro-inflammatory factors trans-activate the expression of cytidine deaminases and suppress the expression of uracil DNA glycosylase. The imbalance between the mutagenic forces and mutation-correcting force
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"Sodium Bisulfite Conversion of Human Genome for DNA Methylation Studies." In Protocols used in Molecular Biology, edited by Aastha Mishra and Qadar Pasha. BENTHAM SCIENCE PUBLISHERS, 2020. http://dx.doi.org/10.2174/9789811439315120010012.

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The regulation of transcription and translation of a gene under a given environment is dependent on several factors and epigenetics is one such factor, responsible for the differential expression of several genes in health and in various diseases. DNA methylation, an important epigenetics mechanism has been shown to play a vital role in numerous cellular processes, and the abnormal patterns of methylation have been linked to the number of human diseases. CpG islands, a short stretch of DNA enriched with CpG sites in the 5’ end of a gene, although remains unmethylated but tends to methylate abe
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Majeed Shah, Ishteyaq, Mashooq Ahmad Dar, Kaiser Ahmad Bhat, Tashook Ahmad Dar, Fayaz Ahmad, and Syed Mudasir Ahmad. "Long Non-Coding RNAs: Biogenesis, Mechanism of Action and Role in Different Biological and Pathological Processes." In Recent Advances in Non-Coding RNAs [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104861.

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RNA or ribonucleic acid constitutes of nucleotides, which are ribose sugars coupled to nitrogenous bases and phosphate groups. Nitrogenous bases include adenine, guanine, cytosine and uracil. Messenger RNA, ribosomal RNA and Transfer RNA are three main types of RNA that are involved in protein synthesis. Apart from its primary role in synthesis of protein, RNA comes in variety of forms like snRNA, miRNA, siRNA, antisense RNA, LncRNA etc., that are involved in DNA replication, post-transcriptional modification, and gene regulation etc. LncRNAs regulate gene expression by various ways including
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Conference papers on the topic "Urachal cancer"

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Moussa, Mohammad Jad, Kiran L. Malikayil, Adrienne H. Chen, et al. "516 Immune checkpoint inhibitors in advanced urachal and non-urachal adenocarcinomas of the urinary tract: the MD Anderson Cancer Center experience." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.0516.

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Bulgar, Alina, Lachelle D. Weeks, Yanling Miao, et al. "Abstract A104: Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: Overriding the limit with methoxyamine (TRC102) to inhibit base excision repair." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-a104.

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Dooper, Marten. "Maintenance tegafur-uracil does not improve survival in locally advanced cervical cancer." In ESMO Congress 2022, edited by Stefan Rauh. Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/0347df39.

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Weeks, Lachelle D., Pingfu Fu, Lili Liu, and Stanton L. Gerson. "Abstract 4484: Uracil DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4484.

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Yan, Yan, Allison Condie, and Stanton Gerson. "Abstract 3854: Inhibition of uracil DNA glycosylase (UDG) sensitizes cancer cells to thymidylate synthase inhibitors." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3854.

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Weeks, Lachelle D., Gabriel Zetner, Peter Scacheri, Lili Liu, and Stanton L. Gerson. "Abstract A100: Pemetrexed-induced uracil accumulation is an importatn source of DNA damage in UNG deficient cells, contributing to hematologic toxicity." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-a100.

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Saji, Shigehira, Shinji Ohno, Norikazu Masuda, et al. "Abstract P2-14-17: Pooled analysis of long-term outcome of patients enrolled in two trials comparing the efficacy of oral tegafur-uracil with CMF (N-SAS-BC01 and CUBC trials)." In Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p2-14-17.

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Murata, Kohei, Hirofumi Yamamoto, Mutsumi Fukunaga, et al. "Abstract 4682: Phase II study of first line chemotherapy with tegafur/uracil and oral leucovorin in elderly patients with advanced or metastatic colorectal cancer." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4682.

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Silva, Manuella Amlid Pimenta de Castro Cavalcanti, Caio Victor Barros Gonçalves da Silva, Dryelli Frances Santana da Silva, Laura Lucena Serafim, Ryan Cristian da Silva, and Celina Cavalcante Muniz Gomes. "A METILAÇÃO DO DNA COMO BIOMARCADOR NO PROGNÓSTICO E DIAGNÓSTICO DO CÂNCER OVARIANO: REVISÃO DE LITERATURA." In XXVII Semana de Biomedicina Inovação e Ciência. Editora IME, 2021. http://dx.doi.org/10.51161/9786588884119/2.

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Introdução: O câncer ovariano é caracterizado pelo crescimento anormal de células provenientes dos ovários. Mutações no gene BRCA podem aumentar, entre 20 a 50%, o risco do paciente desenvolver câncer ovariano (1). Assim, o gene BRCA1 é expresso como autossômico dominante, com penetrância incompleta e atua como supressor de tumor, sendo importante para a reparação do DNA, pois atua na manutenção da estabilidade do genoma e no controle do ciclo celular no checkpoint (3). Desse modo, a metilação do DNA ocorre na região promotora do gene, local dos sítios CpG – sendo denominados assim pois um gru
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Yonemori, K., S. Ohsumi, S. Takao, et al. "Abstract P1-13-09: Long-term follow-up of two randomized controlled trials (N-SAS-BC01 trial and CUBC trial) comparing oral tegafur-uracil (UFT) versus classical cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) as adjuvant therapy in early breast cancer." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p1-13-09.

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