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Dissertations / Theses on the topic 'Uracil'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Studebaker, Adam W. "Targeting uracil exclusion mechanisms for development of anti-viral and anti-cancer therapies." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1056034774.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 210 p.; also includes graphics (some col.). Includes bibliographical references (p. 174-210). Available online via OhioLINK's ETD Center

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2

Kemmerich, Kristin. "Studies of genomic uracil and its excision." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610133.

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3

Kandasamy, Dineshkumar. "Study on yeast enzymes Urc1p and Urc4p in a novel uracil catabolism pathway (URC)." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185013.

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Purine and pyrimidine bases are the central precursors of DNA and RNA and theirintracellular concentration is balanced by three pathways- de novo, salvage and catabolicpathways. Uracil catabolism pathway has been found in several bacteria and in some fungi(including yeast). Seven genes, URC1-7 have been found to be involved in this novelpathway. There are two “unknown genes” in the yeast Lachancea (Saccharomyces) kluyveri,namelyURC1 and URC4, which play a central role in this pathway and their exact functionremains a mystery.In this project, two S. kluyveri genes, URC1&URC4, were over-expr

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4

Dworkin, Jason P. "Alternatives to uracil in the pre-RNA world /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9804027.

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5

Hendrix, Alicia M. "Adenine Uracil Guanine: An Exploration of Certainty in Science." Scholarship @ Claremont, 2012. http://scholarship.claremont.edu/scripps_theses/157.

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Collaboration and communication between conventionally diverse fields can allow for deeper understanding and clearer analysis of the concepts within each. Two fields traditionally seen as dichotomous are those of art and science. Historically they approach problems in opposite ways. However, I would argue that they in fact investigate very similar questions, hoping to discover the ways that the world works. It makes sense, then, that historically these fields have sometimes been able to interact. Artists have engaged with science by creating work through scientific processes including crossbre

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6

Shuttleworth, Gillian. "Uracil recognition by the DNA polymerase from Pyrococcus furiosus." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289269.

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7

Fituri, Hisham Saleh. "Synthesis of uracil containing precursors and analogues of cylindrospermopsin." Thesis, Bangor University, 2015. https://research.bangor.ac.uk/portal/en/theses/synthesis-of-uracil-containing-precursors-and-analogues-of-cylindrospermopsin(3d8eff07-e38b-4988-b4d6-b7942a797035).html.

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The thesis covers three topics: i) Synthesis of the uracil D-ring precursor of the cylindrospermopsin alkaloids: this study entailed the preparation of compounds I and II which were shown to be a RHS D-ring precursor in the synthesis of the cylindrospermopsin alkaloids. Compound I was prepared in 3 steps and in 24% overall yield from dibenzylurea whilst II was prepared from either diethyl 1,3-acetonedicarboxylate in 5 steps and 9% overall yield or barbituric acid in 5 steps and 16% overall yield. ii) Preparation of analogues of cylindrospermopsin: the synthesis of the cylindrospermopsin analog

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8

Dingler, Felix. "Investigations into origin and fate of uracil in the mouse genome." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708713.

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9

Galarza, Andrés Fernando Andrade. "Avaliação genotípica e fenotípica da enzima diidropirimidina desidrogenase (DPD) e risco de toxicidade com o uso de fluoropirimidinas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/143351.

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Base teórica: As fluoropirimidinas possuem significativa variabilidade na resposta terapêutica e na ocorrência de toxicidade, o que tem sido relacionado à deficiência na depuração metabólica mediada pela enzima diidropirimidina desidrogenase (DPD). Mutações nos genes codificadores da enzima, bem como fatores ambientais podem levar à baixa ou nula expressão enzimática, provocando efeitos adversos graves devido ao acúmulo destes fármacos. Até o presente, nenhum teste reconhecidamente valido para a identificação de indivíduos em risco de toxicidade severa está estabelecido na prática oncológica.

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10

Krusong, Kuakarun. "Recognition and repair of DNA damage by uracil DNA glycosylase." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417133.

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11

Choudhury-Bhakta, Romi Roy. "The contribution of different uracil-DNA glycosylases to removal of uracil from DNA in different mouse organs - the significance of sequence context and proliferative status." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kreftforskning og molekylær medisin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25948.

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Uracil is a non-canonical base in DNA that can arise through misincorporation of dUMP instead of dTMP during replication or from cytosine deamination. Uracil in DNA can be removed by the four different DNA glycosylases UNG, SMUG1, TDG or MBD4 as the first step in base excision repair. These glycosylases have different catalytic efficiencies, different substrate preferences and different expression patterns. We wanted to elucidate the contribution of the different DNA glycosylases in removal of uracil, using protein extracts from mouse brain, small intestine, kidney, liver, lung and muscle. Imp

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12

Kimber, Scott T. "Utilising Uracil DNA Glycosylase to detect the presence of 5-methylcytosine." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/372794/.

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DNA is regularly subjected to endogenous and exogenous reagents that cause mutations that can be detrimental to a cell if they are not repaired. One class of enzymes responsible for DNA repair is the family of DNA glycosylases and their role is to remove damaged bases. Uracil DNA Glycosylase (UDG) is a member of this family and is highly specific, removing only uracil, an RNA base, from DNA. Uracil arises in DNA through misincorporation of deoxyuridine monophosphate (dUMP) creating an A.U base pair, or through deamination of cytosine resulting in a G.U base pair. Though UDG acts on A.U pairs,

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13

Wolken, Jill K. "A neutralization-reionization mass spectrometry and computational analysis of 3-hydroxypyridine, 2-hydroxypyridine/2-(1H)pyridone, and uracil /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8659.

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14

Visnes, Torkild. "DNA excision repair of uracil and 5-fluorouracil in human cancercell lines." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kreftforskning og molekylær medisin, 2009. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-6477.

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DNA er et tilsynelatende stabilt molekyl, som overføres så å si uten endringer fra unnfangelse til alderdom og fra generasjon til generasjon. Men arvestoffet vårt er ikke så uforanderlig som det kan se ut som. DNA kan endres kjemisk ved å reagere med en rekke stoffer som er påført utenfra eller som normalt finnes inne i enhver celle. DNA består av repeterende enheter av nukleotider, som igjen består av fosfat-, sukker- og basegrupper. Fosfat og sukkergruppene danner en ryggrad, mens basene parer med andre baser på en motstående DNA-tråd. Fokus for denne avhandlingen er baseskadene uracil og 5-

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15

Merwitz, Otto [Verfasser]. "Die Wasserstoffabspaltung aus γ-bestrahltem ³H-Thymin und ³H-Uracil / Otto Merwitz". Karlsruhe : KIT-Bibliothek, 2008. http://d-nb.info/1186086645/34.

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16

Stefan, Carmen Mirela. "Synthesis of C-nucleoside analogues for mechanistic study of uracil DNA glycosylase." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0002412.

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17

Johnston, Stephen J. "A molecular analysis of dihydropyrimidine dehydrogenase." Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602028.

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Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in the reductive catabolism of the pyrimidine bases uracil and thymine. The clinical relevance of this enzyme is illustrated in individuals presenting with the inherited metabolic disorder thymine uraciluria. This syndrome is characterised by high plasma concentrations of thymine and uracil, and may result in clinical features including mental retardation and dysmorphia. DPD is also clinically relevant in the metabolism and subsequent inactivation of the chemotherapeutic agent 5- fluououracil (5FU). DPD activity has been shown t

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18

Fujita, Marta Akemi. "Síntese de porfirinas contendo grupos do tipo uracil fundidos nas posições β-pirrólicas." Universidade Federal de São Carlos, 2014. https://repositorio.ufscar.br/handle/ufscar/6606.

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Made available in DSpace on 2016-06-02T20:36:54Z (GMT). No. of bitstreams: 1 6474.pdf: 7823491 bytes, checksum: cbbaea4fa6954870c877181c315c0a3d (MD5) Previous issue date: 2014-07-28<br>Universidade Federal de Minas Gerais<br>In this work the synthesis of new porphyrin derivatives were proposed. The preparations of new compounds containing uracil groups at β-pirrolic position were studied based on their interest in organics synthesis. We also have performed reactions with metals salt in order to evaluate the different photophysical properties of the porphyrin complex. In the first step

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19

Webley, Sherael Dorciana. "Components of the uracil misincorporation pathway and cellular response to thymidylate synthase inhibition." Thesis, Institute of Cancer Research (University Of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299993.

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20

Welsh, Sarah Joanne. "The role of uracil misincorporation in cell death following inhibition of thymidylate synthase." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393101.

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21

Studebaker, Adam Wade. "Targteing uracil exclusion mechanisms for development of anti-viral and anti-cancer therapies." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1056034774.

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22

Pollard, Sarah. "Insight Into Enzyme Catalysis Through The Study of B-Phosphoglucomutase And Uracil DNA Glycosylase." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489857.

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Human uracil DNA glycosylase (UDG) excises uracil bases resulting from cytosine deamination or dUMP incorporation into DNA at a rate of 500 per cell per day. UDG is also important in the study of class-switching in immunoglobulins, and in the development of treatments for tuberculosis, cancer and HIV. This thesis studies tautomerisation of the transition state analogue deoxypseudouridine, which enables determination of strain energy of the reaction. This energy is predicted to be 30-40kJ, which is the biggest strain found in any enzyme to date. The crystal structure and solution conformation o

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23

Sarno, Antonio. "Improved determination of genomic uracil content by high performance liquid chromatography-tandem mass spectrometry." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kreftforskning og molekylær medisin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-14401.

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Uracil, a nitrogen base usually found in RNA, may be found in small quantities in genomic DNA. Genomic uracil may arise as a result of deamination of cytosine or misincorporation of deoxyuridine monophosphate (dUMP) instead of deoxythymidine monophosphate (dTMP) by replicative polymerases. Uracil is normally detected as a lesion in DNA and repaired by base excision repair. Failure to do so may lead to genetic mutations. Conversely, the presence of uracil in the genome can be beneficial: it is an important step in the adaptive immunity processes of class switch recombination and somatic hypermu

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24

MAGRI, ANDREA. "Exploration of new uracil-based compounds as novel inhibitors of Hepatitis C Virus replication." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115181.

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Hepatitis C Virus (HCV) is a major public health problem worldwide. While highly efficacious directly-acting antiviral agents have been developed in recent years, their high costs and relative inaccessibility make their use limited. In this thesis, new uracil-based compounds have been evaluated as potential antiviral drugs against HCV. Using several biochemical and virological assays to investigate virus infection and replication, it has been shown that these compounds are able to significantly reduce viral genomic replication with their IC50 values in the nanomolar range. Finally, these compo

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25

Gould, Poppy Aeron. "The role of DNA repair in DNA methylation dynamics." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274360.

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The mammalian epigenome is globally reprogrammed at two stages of development; this involves the erasure and re-establishment of DNA methylation by both passive and active mechanisms, including DNA repair pathways, and occurs concurrently with an increase in developmental potency. In addition to Uhrf1 and the Tet enzymes, the interplay between activation induced cytidine deaminase (AID) and the DNA repair machinery has been implicated in epigenetic reprogramming of various in vivo and in vitro systems including mouse primordial germ cells, zygotes and induced pluripotent stem cells. AID deamin

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26

Pietsch, E. [Verfasser]. "Elektron-Spin-Resonanz-Messungen and α- und γ-bestrahltem Thymin, Uracil und Adenin / E. Pietsch". Karlsruhe : KIT-Bibliothek, 2012. http://d-nb.info/1190100762/34.

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27

Ivanov, A. Yu, S. G. Stepanian, L. Adamowicz, and V. A. Karachevtsev. "Enhancement of infrared absorption of low-temperature uracil thin films by a nanostructured silver surface." AMER INST PHYSICS, 2016. http://hdl.handle.net/10150/622721.

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Enhancement of infrared absorption (SEIRA) of adsorbed biological molecules by a nanostructured metal surface is one of the main routes to increasing the sensitivity of modern optical biosensors. The FTIR absorption spectra of thin films of the RNA base uracil deposited on low-temperature substrate (T = 6K) with nanoscale silver structures were investigated in the spectral range 2700-600 cm(-1). It was shown that the intensity of the absorption bands corresponding to nu CO stretching vibrations (range 1800-1600 cm(-1)) of uracil (Ur) thin films increases 3-4 fold. For multi-layer films, the in

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28

Grippon, Ayse Seden. "Protein complexes in base excision repair : biochemical and kinetic analysis of mismatch uracil DNA glycosylase." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5666.

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Mismatch uracil DNA glycosylase (MUG) is an E. coli enzyme involved in the repair of ethenocytosine and uracil through the base excision repair pathway. MUG is known to bind the abasic site tightly. This may act to protect the abasic lesion, but the question then is how is the site handed over to the AP Endonuclease? Much has been made of the increase in turnover of some DNA glycosylases by AP endonucleases, but it is not clear whether this occurs via an active displacement mechanism or by passive diffusion. We are addressing these questions by studying the kinetics of MUG interactions with it

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29

Bellamy, Stuart Robert William. "A kinetic analysis of substrate recognition by uracil DNA glycosylase from herpes simplex virus type 1." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250977.

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30

Kreutzer, Deborah A. "Oxidative DNA damage : mutagenic properties of 5-hydorxycytosine, 5-hydroxyuracil and uracil glycol in Eschericia coli." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50413.

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31

Earl, Christopher. "Structure and mechanism of a uracil-DNA glycolase essential for γ-herpesviral DNA maintenance and replication". Thesis, Birkbeck (University of London), 2017. http://bbktheses.da.ulcc.ac.uk/227/.

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Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus belonging to the -herpesvirus subfamily. KSHV is the etiologic agent of all forms of Kaposi's sarcoma (KS) and has been linked with the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman's disease. Effcient -herpesvirus DNA replication requires a virally encoded uracil-DNA glycosylase (UNG) as a structural element of the viral replisome. This replication-associated role of viral UNG is independent of UNG substrate catalysis but is mediated by the DNA binding region of UNG. The UNG leuc

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32

Frantz, Eric A. "The Use of Nucleobases in Organic Photodiodes." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448275149.

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33

Starkuviene, Vytaute. "Identification and characterization of thermostable uracil glycosylases from the archaeon Methanobacterium thermoautotrophicum and the bacterium Thermus thermophilus." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965254992.

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34

Cowley, Michael James. "Structural and mechanistic implications of the incorporation of Ethynyl-Uracil into the Coordination Sphere of Transition Metals." Thesis, University of York, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495865.

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35

Lühnsdorf, Bork [Verfasser]. "Einfluss von Uracil in der DNA auf die Genexpression : die Rolle der Basen-Exzisions-Reparatur / Bork Lühnsdorf." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/1072392712/34.

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36

Hendricks, Umraan. "Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/11049.

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In this thesis I will investigate the binding pocket and analyse the nature of binding of the 6-(4-Alkylanilino)-uracil inhibitors in hsvUDG and hUDG to provide a platform for the development of improved inhibitors.

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37

Siddig, Yousif Ashraf. "Differential regulation of S-region hypermutation and class switch recombination by noncanonical functions of uracil DNA glycosylase." Kyoto University, 2014. http://hdl.handle.net/2433/189357.

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The final publication is available at http://dx.doi.org/10.1073/pnas.1402391111. Ashraf S. Yousif, Andre Stanlie, Samiran Mondal, Tasuku Honjo, and Nasim A. Begum. Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase. PNAS 2014 111 (11) E1016-E1024; published ahead of print March 3, 2014.<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医科学)<br>甲第18464号<br>医科博第55号<br>新制||医科||4(附属図書館)<br>31342<br>京都大学大学院医学研究科医科学専攻<br>(主査)教授清水章, 教授萩原正敏, 教授武田俊一<br>学位規則第4条第1項該当

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38

Churchill, Cassandra D. M. "A computational investigation of the formation and structure of DNA intrastrand cross-links initiated by the uracil radical." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, c2011, 2011. http://hdl.handle.net/10133/3117.

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Using computational methods, the formation pathways and structures of four experimentally-observed DNA intrastrand cross-links are determined. These lesions originate from the uracil radical and are of particular importance due to their potential role in the activity of the 5-halouracils as radiosensitizing agents in anti-tumour treatments. The formation pathways are studied with density functional theory under conditions relevant to both UV and ionizing radiation. Results reveal these intrastrand cross-links are likely to form under therapeutic conditions and provide an explanation for their

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39

Hüttermann, Jürgen [Verfasser]. "Elektronenspin-Resonanz freier Radikale in bestrahlten Einkristallen von 5-Halo-Uracil-Derivaten, Desoxyribose und weiteren Nukleinsaeurekomponenten / Jürgen Hüttermann." Karlsruhe : KIT-Bibliothek, 2008. http://d-nb.info/1186272260/34.

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40

Nguyen, My Thanh. "Discovery and Understanding an EffectiveDoor Stopper Inhibitor of the Human Uracil-DNA Glycosylase to Target Base Excision Repair." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case161981808736262.

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41

Guo, Chunguang. "Ugene, a Newly Identified Protein that is Commonly Over-Expressed in Cancer, and that Binds to Uracil DNA-Glycosylase." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1217422102.

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42

Shaw, Ryan W. "Kinetic characterization of site-directed mutants of the conserved active-site phenylalanine of uracil-DNA glycosylase from Escherichia coli." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001448.

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43

Borges, Gleice Rocha Ferreira. "Atividade de derivados de diindolilmetano e de uracil em receptores de ácidos graxos 1 e 4 (FFAR1 e FFAR4)." reponame:Repositório Institucional da UnB, 2018. http://repositorio.unb.br/handle/10482/32264.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas, 2018.<br>Submitted by Raquel Viana (raquelviana@bce.unb.br) on 2018-07-12T18:07:51Z No. of bitstreams: 1 2018_GleiceRochaFerreiraBorges.pdf: 4033638 bytes, checksum: bdf4bec06138b02aaabefb94f878dbde (MD5)<br>Approved for entry into archive by Raquel Viana (raquelviana@bce.unb.br) on 2018-07-14T20:17:47Z (GMT) No. of bitstreams: 1 2018_GleiceRochaFerreiraBorges.pdf: 4033638 bytes, checksum: bdf4bec06138b02aaabefb94f878dbde (MD5)<br>Made available in DSpace on 201

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BROGNARA, Eleonora. "Biological activity of anti-miR-221 Peptide Nucleic Acids and relative building blocks." Doctoral thesis, Università degli studi di Ferrara, 2012. http://hdl.handle.net/11392/2389258.

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The study of new molecules able to selectively and stably interact with DNA and RNA is a field of great interest in consideration all the possible applications in medicine. Our study is related to the biomedical applications of the final product of PNA synthesis (the PNA itself) and the intermediate molecules obtained during the synthetic activity. In all the chemical synthesis approach of any pharmaceutical laboratory several molecules are produced, which are usually not considered for biological assays and technology transfer. We screened a set of C(5) uracil derivatives monomers, tha

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45

Yan, Yan. "Characterization of Uracil DNA Glycosylase as a Therapeutic Target for Sensitization of Floxuridine in Cancer with P53 Mutation or Deficiency." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1499644338014377.

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46

Weeks, Lachelle Dawn. "Elucidating a role for uracil DNA glycosylase (UNG)-initiated DNA base excision repair in the cellular sensitivity to the antifolate, pemetrexed." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386198769.

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47

Villela, Anne Drumond. "Estudos bioquímicos e nocaute gênico da enzima uracil fosforribosil transferase de Mycobacterium tuberculosis como alvo para o desenvolvimento de cepas atenuadas." Pontifícia Universidade Católica do Rio Grande do Sul, 2011. http://hdl.handle.net/10923/1281.

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Made available in DSpace on 2013-08-07T18:41:24Z (GMT). No. of bitstreams: 1 000437675-Texto+Completo-0.pdf: 3014292 bytes, checksum: 10c5c967edfd4e61677f7867c8186a73 (MD5) Previous issue date: 2011<br>Tuberculosis (TB) is an infectious disease mainly caused by Mycobacterium tuberculosis, which currently infects one-third of the world’s population. Despite the availability of the Bacille Calmette-Guérin vaccine and effective short-course chemotherapy, the increasing global burden of TB has been linked to the co-infection with HIV, the emergence of multi, extensively and now totally drug-resi

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Thomas, Holly Reed. "Genetic and epigenetic regulation of dihydropyrimidinase and beta-ureidopropionase in individuals with altered uracil catabolism and normal dihydropyrimidine dehydrogenase enzyme activity." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/thomas.pdf.

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Prado, Fernanda Manso. "Hidroperóxido de timina como fonte biológica de oxigênio molecular singlete [O2 (1Δg)]." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-20072010-162617/.

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A oxidação do DNA por espécies reativas de oxigênio, como o oxigênio molecular singlete [O2 (1Δg)] , pode estar relacionada ao aparecimento de mutações e ao desenvolvimento de doenças. O O2 (1Δg) pode ser gerado biologicamente por reação de fotossensibilização, pela reação de H2O2 e HOCl e pela decomposição de peróxidos orgânicos contendo hidrogênio alfa (α-ROOH), na presença de metais de transição (Fe2+, Cu2+) ou HOCl. A decomposição de α-ROOH, como hidroperóxidos de lipídeos ou proteínas na presença de metais de transição, pode gerar O2 (1Δg) via mecanismo de Russel

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Winters, Thomas Andrew. "Identification, purification, and characterization of two chromatographically distinct species of uracil-DNA glycosylase from herpes simplex virus type 2 infected human cells /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487686243821847.

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