Relevant bibliographies by topics / Uracilo

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Uracilo'

Author: Grafiati
Published: 7 September 2021
Last updated: 14 February 2022

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Journal articles on the topic "Uracilo"

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Lindo-Samanamud, Saúl, Mario Cornejo-Olivas, Olimpio Ortega, Victoria Marca, Keren Espinoza-Huertas, and Pilar Mazzetti. "Estrategia de genotipado del gen FMR1: Método de diagnóstico alternativo para el Síndrome X Frágil y otras enfermedades por expansión de trinucleotidos." Revista Medica Herediana 24, no. 4 (2013): 269. http://dx.doi.org/10.20453/rmh.v24i4.269.

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Objetivos: Diseñar una estrategia alternativa por PCR para el genotipado de secuencias ricas en citosinas, basada en modificación nucleotídica. Material y métodos: Se modificó el gen FMR1 nativo de ocho individuos clínicamente no afectados por el Síndrome X frágil, cambiando las citosinas por uracilos, empleando bisulfito de sodio. El ADN modificado fue purificado y cuantificado por espectrofotometría. Las estructuras alternativas y potenciales islas CpG que adopta el microsatélite inestable fueron simuladas con los programas MFOLD y CpGplot. Se generaron cebadores específicos que hibriden tan
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Trilleras, Jorge, Omar Rodríguez, and Edwin Javier González López. "5-Deazaflavinas: síntesis química." Revista de Ciencias 21, no. 1 (2018): 133. http://dx.doi.org/10.25100/rc.v21i1.6346.

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Las 5-Deazaflavinas, están involucradas en reacciones enzimáticas redox de una variedad de sistemas biológicos y guardan similitud estructural con la riboflavina. Las propiedades electroquímicas y fotoquímicas son resultado de la sustitución del N-5 del anillo de la isoaloxazina por un átomo de carbono. En esta revisión, se describen los avances en la obtención de 5-deazaflavinas y análogos a partir de ácido barbitúrico, análogos de uracilo, triamino-tricloropirimidinas y quinolincarbonitrilos. El grado y tipo de sustitución de las 5-deazaflavinas, se obtiene a través de los aldehídos y aminas
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Bojarska, Elżbieta, Jarosław Kamiński, Ryszard Stolarski, and Zygmunt Kazimierczuk. "Novel Electrochemically Derived Dimers of Methylated Uracils." Zeitschrift für Naturforschung B 52, no. 6 (1997): 742–48. http://dx.doi.org/10.1515/znb-1997-0612.

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Abstract Electrolysis of acetic acid/sodium acetate solutions of N-methylated uracils results in the formation of 5-substituted methyl and acethoxy derivatives. Electrolysis of trifluoroacetic acid/potassium trifluoroacetate solutions of N-1-and N-3-methylated uracils provided, be­ sides 5-trifluoromethyl derivatives, novel N-C uracil dimers. In the case of 1,3-dimethyluracil in trifluoroacetic acid. N-l demethylathion was also observed.
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Maruyama, Tokumi, Shigetada Kozai, Tetsuo Yamasaki, et al. "Synthesis and Antiviral Activity of 1,3-Disubstituted Uracils against HIV-1 and HCMV." Antiviral Chemistry and Chemotherapy 14, no. 5 (2003): 271–79. http://dx.doi.org/10.1177/095632020301400506.

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The development of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) is an efficient strategy for finding new therapeutic agents against human immunodeficiency virus (HIV). A large number of 6-substituted uracil derivatives have been prepared in order to explore new NNRTIs. However, there are few approaches to anti-HIV agents from 1,3-disubstituted uracil derivatives. Therefore, we tried to prepare several 1,3-disubstituted uracils, which were easily obtainable from uracil by preparation under alkali and Mitsunobu conditions, and examined their antiviral activity against HIV-1 and h
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Girelli Zubani, Giulia, Marija Zivojnovic, Annie De Smet, et al. "Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs." Journal of Experimental Medicine 214, no. 4 (2017): 1169–80. http://dx.doi.org/10.1084/jem.20161576.

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During somatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs, respectively. Paradoxically, the MMR-nicking complex Pms2/Mlh1 is apparently dispensable for A-T mutagenesis. Thus, how detection of U:G mismatches is translated into the single-strand nick required for error-prone synthesis is an open question. One model proposed that UNG could cooperate with MMR by excising a second uracil in the vicinity of the
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Isono, Yohei, Norikazu Sakakibara, Paula Ordonez, et al. "Synthesis of 1-benzyl-3-(3,5-dimethylbenzyl)Uracil Derivatives with Potential Anti-HIV Activity." Antiviral Chemistry and Chemotherapy 22, no. 2 (2011): 57–65. http://dx.doi.org/10.3851/imp1844.

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Background: Nine novel uracil analogues were synthesized and evaluated as inhibitors of HIV-1. Methods: Key structural modifications included replacement of the 6-chloro group of 1-benzyl-6-chloro-3-(3,5-dimethylbenzyl)uracil by other functional groups or N1-alkylation of 3-(3,5-dimethylbenzyl)-5-fluorouracil. Results: These compounds showed only micromolar potency against HIV-1 in MT-4, though two of them; 6-azido-1-benzyl-3-(3,5-dimethylbenzyl) uracil and 6-amino-1-benzyl-3-(3,5-dimethylbenzyl) uracil were highly potent (half maximal effective concentration =0.067 and 0.069 μM) and selective
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Heidari, Ali, Arash Ghorbani-Choghamarani, Maryam Hajjami, and Robert H. E. Hudson. "Fluorescent Biaryl Uracils with C5-Dihydro- and Quinazolinone Heterocyclic Appendages in PNA." Molecules 25, no. 8 (2020): 1995. http://dx.doi.org/10.3390/molecules25081995.

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There has been much effort to exploit fluorescence techniques in the detection of nucleic acids. Canonical nucleic acids are essentially nonfluorescent; however, the modification of the nucleobase has proved to be a fruitful way to engender fluorescence. Much of the chemistry used to prepare modified nucleobases relies on expensive transition metal catalysts. In this work, we describe the synthesis of biaryl quinazolinone-uracil nucleobase analogs prepared by the condensation of anthranilamide derivatives and 5-formyluracil using inexpensive copper salts. A selection of modified nucleobases we
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Colasurdo, Diego D., Matías N. Pila, Dacio A. Iglesias, Sergio L. Laurella, and Danila L. Ruiz. "Tautomerism of uracil and related compounds: A mass spectrometry study." European Journal of Mass Spectrometry 24, no. 2 (2017): 214–24. http://dx.doi.org/10.1177/1469066717712461.

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It has been demonstrated that uracil has a preponderant tautomeric form, but it is also known that different tautomers co-exist in this equilibrium. In this work, mass spectrometry is used as a helpful tool to analyse the equilibria, using derivative compounds to forbid the presence of some tautomers and ion trap mass spectrometry to follow relevant fragmentation pathways. Theoretical calculations were performed to confirm tautomers abundance by energy minimization in gas phase. Analysis of mass spectra of uracil, three methyl-substituted uracils, 2-thiouracil and three benzouracils suggest th
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Focher, F., A. Verri, S. Spadari, R. Manservigi, J. Gambino, and G. E. Wright. "Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives." Biochemical Journal 292, no. 3 (1993): 883–89. http://dx.doi.org/10.1042/bj2920883.

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We have purified Herpes simplex type 1 (HSV1) uracil-DNA glycosylase from the nuclei of HSV1-infected HeLa cells harvested 8 h post-infection, at which time the induction of the enzyme is a maximum. The enzyme has been shown to be distinct from the host enzyme, isolated from HeLa cells, by its lack of sensitivity to a monoclonal antibody to human uracil-DNA glycosylase. Furthermore, several uracil analogues were synthesized and screened for their capacity to discriminate between the viral and human uracil-DNA glycosylases. Both enzymes were inhibited by 6-(p-alkylanilino)uracils, but the viral
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Di Noia, Javier M., Gareth T. Williams, Denice T. Y. Chan, Jean-Marie Buerstedde, Geoff S. Baldwin, and Michael S. Neuberger. "Dependence of antibody gene diversification on uracil excision." Journal of Experimental Medicine 204, no. 13 (2007): 3209–19. http://dx.doi.org/10.1084/jem.20071768.

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Activation-induced deaminase (AID) catalyses deamination of deoxycytidine to deoxyuridine within immunoglobulin loci, triggering pathways of antibody diversification that are largely dependent on uracil-DNA glycosylase (uracil-N-glycolase [UNG]). Surprisingly efficient class switch recombination is restored to ung−/− B cells through retroviral delivery of active-site mutants of UNG, stimulating discussion about the need for UNG's uracil-excision activity. In this study, however, we find that even with the overexpression achieved through retroviral delivery, switching is only mediated by UNG mu
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Dissertations / Theses on the topic "Uracilo"

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Matias, Carolina Raquel Guedes. "Decomposição do uracilo por colisões átomo-molécula: formação do anião NCO." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6152.

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Dissertação para obtenção do Grau de Mestre em Engenharia Física<br>A interacção da radiação de alta energia (p.ex. raios-X, raios , partículas ) com o meio fisiológico, produz ao longo do percurso de ionização diversas espécies secundárias (p.ex. iões, radicais, electrões) que podem produzir efeito genotóxico mais relevante do que a radiação primária. Dessas espécies formadas, os electrões secundários são as mais abundantes e podem assim interagir com o ADN celular. Encontra-se bem documentado na literatura que por cada MeV de radiação incidente, produzem-se cerca de 5×104 electrões secundári
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Zamora, F., P. Amo-Ochoa, and B. Lippert. "Nuevos complejos biorganometálicos con iones metálicos pesado por enlace a la posición C(5) del uracilo y la citosina." Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/100135.

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Dias, Cristina Jesus. "Derivados porfirínicos conjugados com uracilalditóis: sínteses e avaliação das suas propriedades antibacterianas e antitumorais." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22680.

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Mestrado em Bioquímica - Métodos Biomoleculares<br>A unidade estrutural uracilo é uma estrutura promissora para a descoberta de novos agentes terapêuticos, uma vez que apresenta uma diversificada atividade biológica. Os derivados de uracilo substituídos na posição C-5, entre os quais se destaca o 5-fluorouracilo, apresentam atividade antitumoral significativa. De igual modo os derivados porfirínicos têm sido amplamente estudados como fotossensibilizadores em terapia fotodinâmica (PDT), destacando-se entre os naturais a clorofila a, precursora de alguns agentes como é o caso da clorina e6 e da
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Galarza, Andrés Fernando Andrade. "Avaliação genotípica e fenotípica da enzima diidropirimidina desidrogenase (DPD) e risco de toxicidade com o uso de fluoropirimidinas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/143351.

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Base teórica: As fluoropirimidinas possuem significativa variabilidade na resposta terapêutica e na ocorrência de toxicidade, o que tem sido relacionado à deficiência na depuração metabólica mediada pela enzima diidropirimidina desidrogenase (DPD). Mutações nos genes codificadores da enzima, bem como fatores ambientais podem levar à baixa ou nula expressão enzimática, provocando efeitos adversos graves devido ao acúmulo destes fármacos. Até o presente, nenhum teste reconhecidamente valido para a identificação de indivíduos em risco de toxicidade severa está estabelecido na prática oncológica.
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Guillet, Marie. "Les sites abasiques, leur origine et les systèmes de répération chez Saccharomyces cerevisiae." Paris 11, 2003. http://www.theses.fr/2003PA112149.

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Les cellules sont constamment soumises à des stress endogène et exogène qui provoquent la formation de lésions de l'ADN. Il a été estimé que les lésions les plus abondantes dans l'ADN sont les sites abasiques (sites AP) provenant du clivage du lien glycosidique entre la base et le désoxyribose. Ce clivage peut être spontané ou médié par une ADN glycosylase au cours la réparation par excision de bases (BER) endommagées ou anormales de l'ADN. Le clivage des sites AP en 5' ou en 3' provoquent la formation de cassures simple brin avec une extrémité 5' ou 3' bloquée, respectivement. Au début de ma
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Studebaker, Adam W. "Targeting uracil exclusion mechanisms for development of anti-viral and anti-cancer therapies." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1056034774.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 210 p.; also includes graphics (some col.). Includes bibliographical references (p. 174-210). Available online via OhioLINK's ETD Center
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Kandasamy, Dineshkumar. "Study on yeast enzymes Urc1p and Urc4p in a novel uracil catabolism pathway (URC)." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185013.

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Purine and pyrimidine bases are the central precursors of DNA and RNA and theirintracellular concentration is balanced by three pathways- de novo, salvage and catabolicpathways. Uracil catabolism pathway has been found in several bacteria and in some fungi(including yeast). Seven genes, URC1-7 have been found to be involved in this novelpathway. There are two “unknown genes” in the yeast Lachancea (Saccharomyces) kluyveri,namelyURC1 and URC4, which play a central role in this pathway and their exact functionremains a mystery.In this project, two S. kluyveri genes, URC1&amp;URC4, were over-expr
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Kemmerich, Kristin. "Studies of genomic uracil and its excision." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610133.

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Brom, Jacques. "Squelettes pyrimidohétérocycliques dérivés d'amino- et d'hydrazino- uraciles." Mulhouse, 1991. http://www.theses.fr/1991MULH0205.

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Les 6-amino-, 6-hydrazino- et 6-(azavinyl) pyrimidinediones riches en électrons réagissent par leur carbone 5 avec différents électrophiles (l’O-tosylisonitrosomalodinitrile (OTMD), le tétracyanoéthylène (TCNE), l'acétylènedicarboxylate de diméthyle (DMAD), et le diméthylacétal du diméthylformamide (DMFDMA) pour conduire après cyclisation à toute une série d'hétérocycles polycycliques. La 6-amino-1,3-diméthylpyrimidine-2,4(1H, 3H)-dione fournit ainsi, avec l'OTMD, une lumazine précurseur de pyrimido [5,4-g] ptéridines, et avec le TCNE, une pyrido [2,3-d] pyrimidine. Une isomérisation du squele
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HANNIER, REGIS. "Les cardiomyopathies au 5 fluoro-uracile (5 fu)." Lille 2, 1990. http://www.theses.fr/1990LIL2M281.

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Books on the topic "Uracilo"

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Pavittiran̲. Uracal ōcaikaḷ. Tēciya Kalai Ilakkiyap Pēravai, 2002.

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McKinnell, Denise. Phototransformation of 5-[inferior t]-butyl uracil derivatives. University of Birmingham, 1997.

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Bouzid, Bachir. Electrochemical behaviour and flow injection determination of uracil derivatives. University of Birmingham, 1987.

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Mutikainen, Ilpo. X-ray structural studies on metal complexes of uracil and orotic acid: A survey of coordination induced changes in the uracil fragment. Suomalainen Tiedeakatemia, 1988.

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National Institute for Clinical Excellence. Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer. National Institute for Clinical Excellence, 2003.

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Paramacivam, Mu. Ti. Ka. Ci. en̲n̲umoru tir̲an̲āyvut ten̲r̲al: 1950-90kaḷil Tamil̲ilakkiya varalāṛṛōṭu tōḷ uraci naṭanta oru man̲itarin̲ carittiram. Narmatā Patippakam, 1999.

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Slupphaug, Geir, and Hans Einar Krokan. Genomic Uracil. WORLD SCIENTIFIC, 2018. http://dx.doi.org/10.1142/10803.

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Krokan, Hans Einar, and Geir Slupphaug. Genomic Uracil: Evolution, Biology, Immunology and Disease. World Scientific Publishing Co Pte Ltd, 2018.

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Sanderson, Russell J. Uracil-DNA glycosylase inhibitor protein: Role of carboxylic acid residues and use for measuring the fidelity of uracil-excision DNA repair synthesis in human cell extracts. 1998.

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Sanderson, Russell J. Uracil-DNA glycosylase inhibitor protein: Role of carboxylic acid residues and use for measuring the fidelity of uracil-excision DNA repair synthesis in human cell extracts. 1998.

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Book chapters on the topic "Uracilo"

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Miyakawa, Shin. "Uracil (Ura)." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_1631-3.

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Miyakawa, Shin. "Uracil (Ura)." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_1631.

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Schomburg, Dietmar, and Dörte Stephan. "Uracil phosphoribosyltransferase." In Enzyme Handbook 12. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_215.

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Miyakawa, Shin. "Uracil (Ura)." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_1631.

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Schomburg, Dietmar, and Dörte Stephan. "Uracil dehydrogenase." In Enzyme Handbook 10. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-57756-7_148.

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Schomburg, Dietmar, and Ida Schomburg. "uracil-DNA glycosylase 3.2.2.27." In Class 2–3.2 Transferases, Hydrolases. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36240-8_123.

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Krokan, Hans E., Frank Skorpen, Marit Otterlei, et al. "Human Uracil-DNA Glycosylase." In Advances in DNA Damage and Repair. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4865-2_18.

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Arnemann, J. "UNG (Uracil-DNA-Glycosidase)." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_3628-1.

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Schomburg, Dietmar, and Dörte Stephan. "tRNA (uracil-5-)-methyltransferase." In Enzyme Handbook 11. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61030-1_33.

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Arnemann, J. "UNG (Uracil-DNA-Glycosidase)." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_3628.

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Conference papers on the topic "Uracilo"

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Stewart, Jessica, Shanqiao Wei, Madhurima Datta, Umesh Varshney, and Ashok Bhagwat. "Abstract 3802: A novel uracil-DNA glycosylase, UdgX, as a new biochemical tool to directly detect uracils in DNA." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3802.

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Kowalski, Konrad, Joanna Skiba, Ingo Ott, Jolanta Solecka, and Bruno Therrien. "Ferrocenylated uracils: synthesis and biology." In XVIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414310.

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Shih, Yu-Chiao, Ying-Shun Liao, Chun-Chi Lin, et al. "Synthesis of 6-substituted uracil and uridine derivatives." In XVIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414129.

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Fritz, Hans-Joachim. "Mechanistic and evolutionary aspects of DNA-uracil glycosylases." In XIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2002. http://dx.doi.org/10.1135/css200205230.

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Lin, Xiumei, Tanja Deckert-Gaudig, Regina Treffer, Volker Deckert, P. M. Champion, and L. D. Ziegler. "Tip-Enhanced Raman Scattering (TERS) Of Uracil Strands." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482412.

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Elkin, P. M., M. A. Erman, and O. V. Pulin. "Anharmonic analysis of vibrational spectra of substituted uracil." In SPIE Proceedings, edited by Vladimir L. Derbov, Leonid A. Melnikov, and Lev M. Babkov. SPIE, 2006. http://dx.doi.org/10.1117/12.696923.

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Grof, P., S. Gaspar, and A. Berces. "Uracil thin layers in dosimetry of UV-radiation." In Europto Biomedical Optics '93, edited by Kazuhiko Atsumi, Cornelius Borst, Frank W. Cross, et al. SPIE, 1994. http://dx.doi.org/10.1117/12.169152.

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Bulgar, Alina, Lachelle D. Weeks, Yanling Miao, et al. "Abstract A104: Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: Overriding the limit with methoxyamine (TRC102) to inhibit base excision repair." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-a104.

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Villar, Vincent, Carlos Casanova, Mari Luz Moreno Sancho, et al. "Antioxidant activity of 5-FU and new fluorinated uracil derivates." In MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition. MDPI, 2017. http://dx.doi.org/10.3390/mol2net-03-04968.

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Fujita, Marta Akemi, Carla Marisa Brito Carvalho, Timothy John Brocksom та Kleber Thiago de Oliveira. "Synthesis and photophysical evaluations of β-fused Uracil- Porphyrin derivatives". У 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013912183035.

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Reports on the topic "Uracilo"

1

González-Pacanowska, Dolores. La dUTPasa, una NTP-pirofosfatasa todo-α que controla el nivel de uracilo en el ADN. Sociedad Española de Bioquímica y Biología Molecular (SEBBM), 2014. http://dx.doi.org/10.18567/sebbmdiv_anc.2014.09.1.

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2

Niedenzu, K., and L. Komorowski. New Boron-Nitrogen Analogues of Uracil Derivatives. Defense Technical Information Center, 1989. http://dx.doi.org/10.21236/ada210164.

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3

Su, Ning, Jerald S. Bradshaw, Xian X. Zhang, Paul B. Savage, and Krzystof E. Krakowiak. Syntheses of Diaza-18-Crown-6 Ligands Containing Two Units Each of 4-Hydroxyazobenzene, Benzimidazole, Uracil, Anthraquinone, or Ferrocene Groups. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada361715.

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