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Journal articles on the topic 'Urease inhibition'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Mohammed, Salih Osman, Sayed H. El El Ashry, Asaad Khalid, et al. "Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives." Molecules 27, no. 3 (2022): 865. http://dx.doi.org/10.3390/molecules27030865.

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The urease enzyme has been an important target for the discovery of effective pharmacological and agricultural products. Thirteen regio-selectively alkylated benzimidazole-2-thione derivatives have been designed to carry the essential features of urease inhibitors. The urease enzyme was isolated from Helicobacter pylori as a recombinant urease utilizing the His-tag method. The isolated enzyme was purified and characterized using chromatographic and FPLC techniques showing a maximal activity of 200 mg/mL. Additionally, the commercial Jack bean urease was purchased and included in this study for

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2

Zusfahair, Zusfahair, Amin Fatoni, Dian Riana Ningsih, and Anung Riapanitra. "Determination of Cu and Pb concentrations based on urease activity inhibition of Durio zibethinus L. seeds." Molekul 16, no. 2 (2021): 92. http://dx.doi.org/10.20884/1.jm.2021.16.2.736.

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The determination of heavy metal concentrations has been carried out using sophisticated instruments, and therefore a simple and reliable alternative method is needed as a comparison. The study aimed to determine Cu and Pb concentration of standard solution using the urease activity inhibition method of Durio zibethinus L. seeds. The research started with urease extraction from Durio D. zibethinus L. seeds. The activity of the obtained extract was determined using the Nessler method. The optimum substrate concentration was also determined. Urease activity inhibition was carried out using vario

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3

Tan, Lirong, Jiyan Su, Dianwei Wu, et al. "Kinetics and Mechanism Study of Competitive Inhibition of Jack-Bean Urease by Baicalin." Scientific World Journal 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/879501.

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Baicalin (BA) is the principal component of Radix Scutellariae responsible for its pharmacological activity. In this study, kinetics and mechanism of inhibition by BA against jack-bean urease were investigated for its therapeutic potential. It was revealed that the IC50of BA against jack-bean urease was2.74 ± 0.51 mM, which was proved to be a competitive and concentration-dependent inhibition with slow-binding progress curves. The rapid formation of initial BA-urease complex with an inhibition constant ofKi=3.89 × 10−3 mM was followed by a slow isomerization into the final complex with an over

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4

Kataria, Ritu, and Anurag Khatkar. "Lead Molecules for Targeted Urease Inhibition: An Updated Review from 2010 -2018." Current Protein & Peptide Science 20, no. 12 (2019): 1158–88. http://dx.doi.org/10.2174/1389203720666190320170215.

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The field of enzyme inhibition is a tremendous and quickly growing territory of research. Urease a nickel containing metalloenzyme found in bacteria, algae, fungi, and plants brings hydrolysis of urea and plays important role in environmental nitrogen cycle. Apart from this it was found to be responsible for many pathological conditions due to its presence in many microorganisms such as H. Pylori, a ureolytic bacteria having urease which elevates pH of gastric medium by hydrolyzing urea present in alimentary canal and help the bacteria to colonize and spread infection. Due to the infections ca

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5

Rana, Muhammad Ajmal, Rashid Mahmood, and Sajid Ali. "Soil urease inhibition by various plant extracts." PLOS ONE 16, no. 10 (2021): e0258568. http://dx.doi.org/10.1371/journal.pone.0258568.

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Urea is the most popular and widely used nitrogenous fertilizer. High soil urease activity rapidly hydrolyses applied urea to ammonia which contributes to soil nitrogen (N) losses and reduces N use efficiency of crop plants. The ammonia losses can be minimized by the inhibition of soil urease activity which has been explored using various potential chemical inhibitors. However, the soil urease activity inhibition potential of plant extracts is rarely explored to date. In the present study, extracts of 35 plant materials were taken and evaluated against jack bean urease. Eleven extracts, showin

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Wang, Xiao Feng, Huai Dong Bao, and Jie Min Cheng. "The Effect of nanoFe₃O₄ Particles on the Soil Urease and Catalase Activity." Advanced Materials Research 864-867 (December 2013): 853–56. http://dx.doi.org/10.4028/www.scientific.net/amr.864-867.853.

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Effects of nanoFe3O4 particles with different content on the soil urease and catalase activities in pakchoi planting soil were analyzed by pot culture. The results showed that after nanoFe3O4 was added the soil urease and catalase activities were significantly inhibited. In the groups treated with 1%, 2% and 3% nanoFe3O4, the soil urease activity was significantly decreased by 13.9%25.2%33.6% , and the soil catalase activity was significantly decreased by 9.59%10.26%33.04% compared with the control group. It followed that nanoFe3O4 played an inhibiting role in the soil urease and catalase acti

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7

Zhang, Xiaoyin, Yue He, Zhanbo Xiong, et al. "Chelerythrine Chloride: A Potential Rumen Microbial Urease Inhibitor Screened by Targeting UreG." International Journal of Molecular Sciences 22, no. 15 (2021): 8212. http://dx.doi.org/10.3390/ijms22158212.

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Inhibition of ruminal microbial urease is of particular interest due to its crucial role in regulating urea-N utilization efficiency and nitrogen pollution in the livestock industry. Acetohydroxamic acid (AHA) is currently the only commercially available urease inhibitor, but it has adverse side effects. The urease accessory protein UreG, which facilitates the functional incorporation of the urease nickel metallocentre, has been proposed in developing urease inhibitor through disrupting urease maturation. The objective of this study was to screen natural compounds as potential urease inhibitor

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8

Rauf, Abdur, Muhammad Ibrahim, Naveed Muhammad, et al. "Enzyme Inhibitory Activities of Extracts and Carpachromene from the Stem of Ficus benghalensis." BioMed Research International 2022 (December 20, 2022): 1–6. http://dx.doi.org/10.1155/2022/7053655.

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Ficus benghalensis is one of the potential medicinal plants which is used locally for the treatment of various ailments such as diabetes, antiasthmatic, and wound healing. To provide a scientific background to these folklores, the current study was designed to evaluate the extract and isolated compound against various enzymes such as ureases, tyrosinase, and phosphodiesterase. The methanolic extract and carpachromene demonstrated a significant urease inhibition effect with maximum percent inhibition of 72.09 and 92.87%, respectively. Regarding the tyrosinase inhibition, the percent antagonist

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9

Kumar, Sandeep. "Urease: Occurrence, inhibition and immobilization." South Asian Journal of Food Technology and Environment 02, no. 3and4 (2016): 418–31. http://dx.doi.org/10.46370/sajfte.2016.v02i03and04.01.

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10

Aniceto, Natália, Tânia S. Albuquerque, Vasco D. B. Bonifácio, Rita C. Guedes, and Nuno Martinho. "Using Machine Learning and Molecular Docking to Leverage Urease Inhibition Data for Virtual Screening." International Journal of Molecular Sciences 24, no. 9 (2023): 8180. http://dx.doi.org/10.3390/ijms24098180.

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Urease is a metalloenzyme that catalyzes the hydrolysis of urea, and its modulation has an important role in both the agricultural and medical industry. Even though numerous molecules have been tested against ureases of different species, their clinical translation has been limited due to chemical and metabolic stability as well as side effects. Therefore, screening new compounds against urease would be of interest in part due to rising concerns regarding antibiotic resistance. In this work, we collected and curated a diverse set of 2640 publicly available small-molecule inhibitors of jack bea

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11

Nie, Jin Xia, Ping Huang, and Da Chao Zhang. "Study on Effect of Heavy Metal and Rare Earth Metal on Soil Activities." Advanced Materials Research 356-360 (October 2011): 1126–30. http://dx.doi.org/10.4028/www.scientific.net/amr.356-360.1126.

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In recent years, as public awareness on environmental problems increasing, soil pollutions are received more and more attention. Choosing a suburban garden soil as objective, adding exogenous heavy metal cadmium (Cd) and rare-earth element lanthanide (La) in the soil, Cd/La single stress and combined stress on soil urease and catalase were studied. The results showed that under Cd/La single or combined processing, both soil urease and catalase activities decrease while the concentration increases. With the incubation time extending, soil urease activities first increase and then decrease, and

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12

Yadav, Neelam, Sonu Chauhan, Sarita Sangwan, Ravi Kumar, and Deepak. "Recent Advances in Anti-Urease Activity of Schiff Bases and their Metal Complexes." Asian Journal of Chemistry 36, no. 4 (2024): 779–94. http://dx.doi.org/10.14233/ajchem.2024.31333.

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The urease enzyme, found in plants, fungi and bacteria, plays a crucial role in catalyzing the hydrolysis of urea, a process integral to microbial metabolism. Its ureolytic activities have garnered significant attention for their impact on agriculture and the health of living organisms. Notably, urease activity in the human stomach, urinary tract and animal cells can lead to pathogenic outcomes. Schiff bases, characterized by their carbonyl-type imine or azomethine linkage, are recognized for their diverse biological effects, including anti-urease activity. Additionally, the metal complexes de

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13

Khuram, Ashfaq* Bashir A. choudhary Muhammad Uzair Muhammad Naeem Qaisar Sajid N. Hussain1 Muhammad A. Ghaffari. "EVALUATION OF α-GLUCOSIDASE, UREASE INHIBITION AND ANTIOXIDANT POTENTIAL OF ACACIA JACQUEMONTII AND RHAMNUS PERSICA." Indo American Journal of Pharmaceutical Sciences 04, № 10 (2017): 3913–18. https://doi.org/10.5281/zenodo.1035239.

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The aim of this study was to investigate antioxidant, urease and α-glucosidase inhibition activities of the plants Acacia jacquemontii and Rhamnus persica. Dichloromethane and methanol extracts of the plants were evaluated for described activities. In α-glucosidase inhibition assay, dichloromethane and methanolic extracts of Acacia jacquemontii exhibited inhibitory activity of 97.9 % and 98.9 % with IC50 of 4.8 μg/ml and 1.2 μg/ml respectively while that of Rhamnus persica showed 68.8 % and 24.5% with IC50 values of 29.3 and 614.5 μg/ml respectively. The results were compared with standard, Ac

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14

Nakamura, Hiroki, Hironori Yoshiyama, Hiroaki Takeuchi, Tomoko Mizote, Kiwamu Okita, and Teruko Nakazawa. "Urease Plays an Important Role in the Chemotactic Motility of Helicobacter pylori in a Viscous Environment." Infection and Immunity 66, no. 10 (1998): 4832–37. http://dx.doi.org/10.1128/iai.66.10.4832-4837.1998.

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ABSTRACT Helicobacter pylori exhibits chemotactic responses to urea, flurofamide, acetohydroxamic acid, and sodium bicarbonate. In buffer, the chemotactic activities of a urease-positive strain were higher than those of the isogenic urease-negative strain. Moreover, the chemotactic activities of the urease-positive strain were increased in a viscous solution containing 3% polyvinylpyrrolidone, whereas those of the urease-negative mutant were not. These results are in accordance with the fact that the mutant strain did not show swarming in motility agar regardless of having flagella. Incubation

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15

Ahmad, Saghir, Muhammad Abdul Qadir, Mahmood Ahmed, et al. "New Acetamide-Sulfonamide-Containing Scaffolds: Antiurease Activity Screening, Structure-Activity Relationship, Kinetics Mechanism, Molecular Docking, and MD Simulation Studies." Molecules 28, no. 14 (2023): 5389. http://dx.doi.org/10.3390/molecules28145389.

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The development of novel scaffolds that can increase the effectiveness, safety, and convenience of medication therapy using drug conjugates is a promising strategy. As a result, drug conjugates are an active area of research and development in medicinal chemistry. This research demonstrates acetamide–sulfonamide scaffold preparation after conjugation of ibuprofen and flurbiprofen with sulfa drugs, and these scaffolds were then screened for urease inhibition. The newly designed conjugates were confirmed by spectroscopic techniques such as IR, 1HNMR, 13CNMR, and elemental analysis. Ibuprofen con

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16

Amtul, Z., Bentham Science Publisher Atta-ur-Rahman, R. Siddiqui, and M. Choudhary. "Chemistry and Mechanism of Urease Inhibition." Current Medicinal Chemistry 9, no. 14 (2002): 1323–48. http://dx.doi.org/10.2174/0929867023369853.

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17

Zaborska, Wiesława, Barbara Krajewska, Maciej Leszko, and Zofia Olech. "Inhibition of urease by Ni2+ ions." Journal of Molecular Catalysis B: Enzymatic 13, no. 4-6 (2001): 103–8. http://dx.doi.org/10.1016/s1381-1177(00)00234-4.

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18

Cao, Xuan, Hui Fen Liu, Jian Chao Hao, and Chong Mei She. "The Influence of Hg on Soil Enzyme Activity under Different Nitrogen Levels." Advanced Materials Research 955-959 (June 2014): 3701–4. http://dx.doi.org/10.4028/www.scientific.net/amr.955-959.3701.

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The effect of heavy metal Hg on activities of soil urease, catalase and invertase in corn field with different nitrogen supplying levels.. The concentrations of Hg2+ were 0, 0.3125, 0.625, 1.25, 2.50 mg·kg-1 dried soil, respectively. The three enzymes responded differently to Hg stress under different N treatments, the inhibition effect of Hg on urease activity was most significant, while the inhibition on catalase only existed at high nitrogen levels, the response of soil invertase under Hg stress firstly increased and then decreased. Under different nitrogen levels, the inhibition of Hg on t

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19

Shahzadi, Kiran, Syed Majid Bukhari, Asma Zaidi, et al. "Novel Coumarin Derivatives as Potential Urease Inhibitors for Kidney Stone Prevention and Antiulcer Therapy: From Synthesis to In Vivo Evaluation." Pharmaceuticals 16, no. 11 (2023): 1552. http://dx.doi.org/10.3390/ph16111552.

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The presence of ammonium ions in urine, along with basic pH in the presence of urease-producing bacteria, promotes the production of struvite stones. This causes renal malfunction, which is manifested by symptoms such as fever, nausea, vomiting, and blood in the urine. The involvement of urease in stone formation makes it a good target for finding urease enzyme inhibitors, which have the potential to be developed as lead drugs against kidney stones in the future. The documented ethnopharmacology of coumarin 2-one against bacterial, fungal and viral strains encouraged us to synthesize new deriv

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20

Lisnyak, Yu. V., and A. V. Martynov. "DOCKING STUDY OF MOLECULAR MECHANISM BEHIND THE QUERCETIN INHIBITION OF MYCOBACTERIUM TUBERCULOSIS UREASE." Annals of Mechnikov Institute, no. 2018-4 (January 23, 2019): 54–60. https://doi.org/10.5281/zenodo.2547472.

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<strong>Introduction. </strong><em>          Mycobacterium tuberculosis</em> urease (MTU), being an important factor of the bacterium viability and virulence, is an attractive target for anti-tuberculosis drugs acting by inhibition of urease activity. However, known urease inhibitors (phosphorodiamidates, hydroxamic acid derivatives and imidazoles) are toxic and/or unstable, that prevent their clinical use. Therefore, the development of novel efficient and safe MTU inhibitors is necessary. To achieve this goal, we have chosen flavonoid quercetin as

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21

Ismail, Muhammad, Javid Hussain, Arif-ullah Khan, et al. "Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities ofGeranium wallichianum." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/305906.

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The present study describes the phytochemical investigations of the crude extracts of rhizomes and leaves ofGeranium wallichianum. The crude extracts were fractionated to obtainn-hexane, ethyl acetate, andn-butanol fractions, which were subjected to different biological activities and enzyme inhibition assays to explore the therapeutic potential of this medicinally important herb. The results indicated that the crude extracts and different fractions of rhizomes and leaves showed varied degree of antimicrobial activities and enzyme inhibitions in different assays. Overall, the rhizome extract a

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22

Lekmine, Sabrina, Ouided Benslama, Bachir Bensalah, et al. "Bioactive Phenolics of Hyoscyamus muticus L. Subsp. Falezlez: A Molecular and Biochemical Approach to Antioxidant and Urease Inhibitory Activities." International Journal of Molecular Sciences 26, no. 1 (2025): 370. https://doi.org/10.3390/ijms26010370.

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This study examines the chemical composition, antioxidant properties, and urease inhibitory effects of Hyoscyamus muticus L. subsp. falezlez (Coss.) Maire. Using LC-ESI-MS/MS, 19 distinct phenolic compounds were identified, with chlorogenic acid being the most abundant. The ethanol extract demonstrated notable antioxidant activity, highlighting its potential for therapeutic use. Urease inhibition assays revealed a remarkable 91.35% inhibition by the H. muticus extract, with an IC50 value of 5.6 ± 1.20 μg/mL, indicating its promising role in addressing conditions linked to urease activity. Mole

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Breitenbach, J. M., and R. P. Hausinger. "Proteus mirabilis urease. Partial purification and inhibition by boric acid and boronic acids." Biochemical Journal 250, no. 3 (1988): 917–20. http://dx.doi.org/10.1042/bj2500917.

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Urease was purified 800-fold and partially characterized from Proteus mirabilis, the predominant microorganism associated with urinary stones. Boric acid is a rapid reversible competitive inhibitor of urease. The pH-dependence of inhibition exhibited pKa values of 6.25 and 9.3, where the latter value is probably due to the inherent pKa of boric acid. Three boronic acids also were shown to inhibit urease competitively.

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You, Zhonglu, Mingyang Liu, Cunfang Wang, et al. "Inhibition studies of Helicobacter pylori urease with Schiff base copper(ii) complexes." RSC Advances 6, no. 20 (2016): 16679–90. http://dx.doi.org/10.1039/c6ra00500d.

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Nine new copper(ii) complexes derived from various Schiff bases were prepared. Five complexes show effective urease inhibitory activities. Complex5has the most effective activity against urease, with a mixed competitive inhibition mechanism.

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25

Headon, D. R., and G. Killeen. "Effects of Yucca schidigera extract on Bacillus pasteurii urease activity." Proceedings of the British Society of Animal Production (1972) 1993 (March 1993): 160. http://dx.doi.org/10.1017/s0308229600024843.

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Yucca schidigera extracts have been reported to reduce noxious gases such as ammonia in animal rearing facilities when incorporated into the diet. Ammonia reduction effects have been hypothesised to be due to inhibition of microbial urease by the extract The effect of a commercial extract, (De-Odorase, Alltech Inc., Nicholasville, Kentucky, U.S.A.), on the activity of urease enzyme from Bacillus pasteurii was determined by measuring the ammonia generated from the breakdown of urea using a modified Berthelot assay. The basis of this assay is the reaction of ammonia, hypochlorite and phenol to g

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Fareed, Ghulam, Nighat Afza, Ali Versiani, et al. "Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives." Journal of the Serbian Chemical Society 78, no. 8 (2013): 1127–34. http://dx.doi.org/10.2298/jsc120917126f.

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A series of 4-aryl methylidene-2-phenyl/methyl-5-(4H)-oxazolone derivatives (2-7) have been synthesized using the reported method by condensation of aldehydes with N-benzoyl / N-acetyl glycine in the presence of zinc oxide as a catalyst and acetic anhydride at room temperature in ethanol. The compounds (2-6) are new derivatives. The structures of compounds were evaluated on the basis of 1H-NMR, 13C-NMR, EIMS, FT-IR and elemental analysis. All the compounds were screened for their antibacterial and urease inhibition activity. Antibacterial activity was tested by agar well diffusion method using

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27

Yakan, Hasan, Seyhan Ozturk, Elvan Uyar Tolgay, et al. "Kinetic Studies, Antioxidant Activities, Enzyme Inhibition Properties and Molecular Docking of 1,3-Dihydro-1,3-Dioxoisoindole Derivatives." Acta Chimica Slovenica 70, no. 1 (2023): 29–43. http://dx.doi.org/10.17344/acsi.2022.7808.

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The acid catalyzed hydrolysis of the N-(p-substitutedphenyl) phthalimides in three different acids was investigated at 50.0 ± 0.1 °C. Two different antioxidant activity tests as DPPH• and ABTS•+ scavenging activities, and three various enzyme inhibition activity tests as urease, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibition activities, were applied. Compound 3c (2.03 μg/mL ) has higher antioxidant activity than other compounds and standards according to DPPH test. In AChE assay, compounds 3a and 3b (13.13 and 9.59 μg/mL) has higher enzyme inhibition activity than the

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Blessing Onyeka Olebunne, Ozadheoghene Eriarie Afieroho, Mikailu Suleiman, and Kio Anthony Abo. "Evaluation of urease inhibitory and free radical scavenging activities of Microsorum pustulatum (G. Frost) copel leaves (Polypodiaceae)." International Journal of Biological and Pharmaceutical Sciences Archive 4, no. 1 (2022): 025–32. http://dx.doi.org/10.53771/ijbpsa.2022.4.1.0075.

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Microsorum pustulatum is an epiphytic fern. Young leaves and stems are edible, used in wound healing (ulcer), treatment of inflammation and skin infections. This study is reporting the effect of the leaves extracts and fractions of Microsorum pustulatum on the urease enzyme as well as their free radical scavenging activity. The leaves extracts were obtained by successive cold maceration in n-hexane, acetone and 70% aqueous ethanol. Phytochemical screening was done using standard methods. Urease inhibition assay was done using the modified Berthelot method with thiourea as reference standard ur

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Juhr, N. C., and M. Ladeburg. "Intestinal accumulation of urea in germ-free animals - a factor in caecal enlargement." Laboratory Animals 20, no. 3 (1986): 238–41. http://dx.doi.org/10.1258/002367786780865665.

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To examine the connection between caecal size and urea concentration in the caecal contents urease inhibition was tested in conventional animals and urea and urease were administered to germ-free rats and mice. Administration of alloxan and barbituric acid and immunization with urease led to slightly larger caeca in conventional animals. Neomycin treatment caused a clear enlargement of the caecum. In germ-free animals urease administration led to a reduction in the caecal size, whereas urea in the drinking water caused enlargement. The urea concentration and the urease activity in the caecal c

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Bonne, Samuel, Muhammad Saleem, Muhammad Hanif, et al. "Synthesis, Urease Inhibition, Molecular Docking, and Optical Analysis of a Symmetrical Schiff Base and Its Selected Metal Complexes." Molecules 29, no. 20 (2024): 4899. http://dx.doi.org/10.3390/molecules29204899.

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Designing and developing small organic molecules for use as urease inhibitors is challenging due to the need for ecosystem sustainability and the requirement to prevent health risks related to the human stomach and urinary tract. Moreover, imaging analysis is widely utilized for tracking infections in intracellular and in vivo systems, which requires drug molecules with emissive potential, specifically in the low-energy region. This study comprises the synthesis of a Schiff base ligand and its selected transition metals to evaluate their UV/fluorescence properties, inhibitory activity against

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Park, Hyun Jun, and Jin Hee Park. "Effect of pyroligneous acids on urease inhibition." Journal of Applied Biological Chemistry 60, no. 2 (2017): 173–78. http://dx.doi.org/10.3839/jabc.2017.028.

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Bugnoli, Massimo, Pietro F. Bayeli, Rino Rappuoli, Carlo Pennatini, Natale Figura, and Jean E. Crabtree. "Inhibition of Helicobacter pylori urease by omeprazole." European Journal of Gastroenterology & Hepatology 5, no. 9 (1993): 683–86. http://dx.doi.org/10.1097/00042737-199309000-00003.

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Tarun, E. I., D. B. Rubinov, and D. I. Metelitza. "Inhibition of soybean urease by polycarbonyl compounds." Applied Biochemistry and Microbiology 41, no. 1 (2005): 12–17. http://dx.doi.org/10.1007/s10438-005-0003-y.

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Tarun, E. I., D. B. Rubinov, and D. I. Metelitza. "Inhibition of soybean urease by triketone oximes." Biochemistry (Moscow) 69, no. 12 (2004): 1344–52. http://dx.doi.org/10.1007/s10541-005-0079-2.

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Kot, M., W. Zaborska, and A. Juszkiewicz. "Inhibition of jack bean urease by thiols." Thermochimica Acta 354, no. 1-2 (2000): 63–69. http://dx.doi.org/10.1016/s0040-6031(00)00451-2.

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36

Volotovsky, Viatcheslav, and Namsoo Kim. "EDTA Determination by Urease-Based Inhibition Biosensor." Electroanalysis 10, no. 1 (1998): 61–63. http://dx.doi.org/10.1002/(sici)1521-4109(199801)10:1<61::aid-elan61>3.0.co;2-1.

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Hendrickson, L. L., and M.-J. O'Connor. "Urease inhibition by decomposition products of phenylphosphorodiamidate." Soil Biology and Biochemistry 19, no. 5 (1987): 595–97. http://dx.doi.org/10.1016/0038-0717(87)90104-0.

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38

Ghauri, Aymen Owais, Muhammad Adeel Arshad, Sana Khalid, and Muhammad Bilal. "In vitro Anti-ulcer potential of Raphanus sativus L. seeds." International Journal of Natural Medicine and Health Sciences 1, no. 1 (2021): 1–8. http://dx.doi.org/10.52461/ijnms.v1i1.742.

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Background: Raphanus sativus L. is an indigenous plant that is traditionally used to treat peptic ulcer. Objective: This study assessed anti- Helicobacter pylori, antioxidant, and anti-urease activities of R. sativus seeds. Methods: this study targeted in-vitro model. The antioxidant activity of the methanol extract and n-butanol, aqueous, n- hexane and chloroform fractions of R. sativus seeds was determined using DPPH. Moreover, the inhibitory effects of the extract and fractions on the activity of urease and antibacterial activity against Helicobacter pylori were also evaluated. Results: The

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Rasheed, Samina, Mubashir Aziz, Aamer Saeed, et al. "Analysis of 1-Aroyl-3-[3-chloro-2-methylphenyl] Thiourea Hybrids as Potent Urease Inhibitors: Synthesis, Biochemical Evaluation and Computational Approach." International Journal of Molecular Sciences 23, no. 19 (2022): 11646. http://dx.doi.org/10.3390/ijms231911646.

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Urease is an amidohydrolase enzyme that is responsible for fatal morbidities in the human body, such as catheter encrustation, encephalopathy, peptic ulcers, hepatic coma, kidney stone formation, and many others. In recent years, scientists have devoted considerable efforts to the quest for efficient urease inhibitors. In the pharmaceutical chemistry, the thiourea skeleton plays a vital role. Thus, the present work focused on the development and discovery of novel urease inhibitors and reported the synthesis of a set of 1-aroyl-3-[3-chloro-2-methylphenyl] thiourea hybrids with aliphatic and ar

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Elif, Ayşe Erdoğan Eliuz, and Sıcak Yusuf. "Antimicrobial and Urease Inhibition Activity of Volatile Oil Obtained from Aerial Parts of Thyme (Thymus vulgaris L.)." Journal of Ongoing Chemical Research 3, no. 2 (2018): 67–70. https://doi.org/10.5281/zenodo.2555611.

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The demand for T. vulgaris L. (Thyme) and its derivates has become popular since it has many biologically active components such as mainly antimicrobial, antiinflammatory, antioxidant characteristics. Especially, there are many studies on the antimicrobial performance oTf. vulgaris L. essential oil. In this study, we analyzed the content of the essential oil of T. vulgaris aerial parts by using GCMS, its antimicrobial activity to some pathogens and urease inhibition activity. The major components of the oil in thyme were thymol (48.80%)γ, -terpinene (15.26%),&nbs

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Kim, Sung-A., Jin-Hong Baek, and Shin-Young Lee. "Effect of DIS Process on in vitro Physiological Functionality of Aloe vera Gel." Food Engineering Progress 13, no. 4 (2009): 251–61. http://dx.doi.org/10.13050/foodengprog.2009.13.4.251.

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In vitro physiological functions such as jack bean (Canavalia ensiformis) urease inhibitory activity and retarding effect of glucose/bile acid of Aloe vera gel concentrated by the optimized DIS (Dewatering Impregnation & Soaking) process conditions were examined. Urease inhibitory activity of DIS aloes ranged from 84.6 to 94.4%, which was similar to or higher than 86.3% of fresh aloe. Also, urease inhibitory activity of DIS aloes was maintained at initial levels after heat treatment (90°C, 10 min.) and drying treatment (freeze or hot air drying). Urease inhibition pattern from Lineweaver-B

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Alamzeb, Muhammad, Muhammad Omer, Mamoon Ur-Rashid, et al. "NMR, Novel Pharmacological and In Silico Docking Studies of Oxyacanthine and Tetrandrine: Bisbenzylisoquinoline Alkaloids Isolated fromBerberis glaucocarpaRoots." Journal of Analytical Methods in Chemistry 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/7692913.

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Urease enzyme is responsible for gastric cancer, peptic ulcer, hepatic coma, and urinary stones in millions of people across the world. So, there is a strong need to develop new and safe antiurease drugs, particularly from natural sources. In search for new and effective drugs from natural sources bioassay-guided fractionation and isolation ofBerberis glaucocarpaStapf roots bark resulted in the isolation and characterization, on the basis of 1D and 2D NMR data, of two bisbenzylisoquinoline alkaloids, oxyacanthine (1) and tetrandrine (2), followed by urease inhibition studies. Crude extract, al

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Kataria, Ritu, and Anurag Khatkar. "In-silico Designing, ADMET Analysis, Synthesis and Biological Evaluation of Novel Derivatives of Diosmin Against Urease Protein and Helicobacter pylori Bacterium." Current Topics in Medicinal Chemistry 19, no. 29 (2019): 2658–75. http://dx.doi.org/10.2174/1568026619666191114123452.

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Background: Designing drug candidates against the urease enzyme, which has been found responsible for many pathological disorders in human beings as well as in animals, was done by insilico means. Methods: Studies were carried out on a designed library of diosmin derivatives with the help of Schrodinger’s maestro package of molecular docking software against a crystallographic complex of plant enzyme Jack bean urease (PDB ID: 3LA4). Best twelve derivatives of diosmin were selected for synthesis by considering their interaction energy along with docking score and were further investigated for a

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Suenaga, Shunya, Yu Takano, and Toru Saito. "Unraveling Binding Mechanism and Stability of Urease Inhibitors: A QM/MM MD Study." Molecules 28, no. 6 (2023): 2697. http://dx.doi.org/10.3390/molecules28062697.

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Soil bacteria can produce urease, which catalyzes the hydrolysis of urea to ammonia (NH3) and carbamate. A variety of urease inhibitors have been proposed to reduce NH3 volatilization by interfering with the urease activity. We report a quantum mechanics/molecular mechanics molecular dynamics (QM/MM MD) study on the mechanism employed for the inhibition of urease by three representative competitive inhibitors; namely, acetohydroxamic acid (AHA), hydroxyurea (HU), and N-(n-butyl)phosphorictriamide (NBPTO). The possible connections between the structural and thermodynamical properties and the ex

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& et al., Hussein. "DETERMINATION OF THE OPTIMUM CONDITIONS FOR UREASE INHIBITTION EXTRACTED FROM SOME LOCAL PLANTS." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 52, no. 4 (2021): 802–9. http://dx.doi.org/10.36103/ijas.v52i4.1389.

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In the current study, four types of plants commonly used namely Soybean, chickpea, bean, pea were obtained and screened for urease activity, among this plants, chickpea was chosen with maximum enzymatic activity, and it had the highest productivity of urease enzyme (1243 U/mg protein). Also sodium acetate buffer (0.2 M, pH 5.0) was chosen as a best extraction buffer with specific activity 1460 U/mg protein. The optimum extraction ratio represented by 1:8 (w:v) after 15 min, it was given 1988 U/mg protein. As well as four types of plants include garlic, red onion, green onion and cabbage were u

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Xue, Ling-Wei, Qiao-Ru Liu, and Yong-Jun Han. "Synthesis, Characterization, Crystal Structures and Urease Inhibition of Some Thiosemicarbazones." Acta Chimica Slovenica 71, no. 1 (2024): 39–46. http://dx.doi.org/10.17344/acsi.2023.8027.

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Six new thiosemicarbazones were prepared and structurally characterized by elemental analysis, NMR and IR spectra and single-crystal X-ray diffraction. The compounds were evaluated for their Jack bean urease inhibitory activities. Among the compounds, those with hydroxyl and chloro substituent groups have effective activity with IC50 values of 1.8-12.7 μmol L–1. Docking simulations were performed to insert the molecules of the compounds into the active urease site determined by the crystal structure to determine their probable binding modes.

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Iqbal, Sarosh, Ajmal Khan, Rashid Nazir та ін. "Synthesis ofβ-Ketosulfone Derivatives As New Non-Cytotoxic Urease InhibitorsIn Vitro". Medicinal Chemistry 16, № 2 (2020): 244–55. http://dx.doi.org/10.2174/1573406415666190415163309.

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Background:Peptic ulcer and urolithiasis are largely due to infection caused by ureaseproducing bacteria. Therefore, the discovery of urease inhibitors is an important area of medicinal chemistry research.Objective:The main aim of the work was to identify novel urease inhibitors with no cytotoxicity.Method:During the current study, a series of β-ketosulfones 1-26 was synthesized in two steps and evaluated for their in vitro urease inhibition potential.Results:Out of twenty-six compounds, seventeen have shown good to significant urease inhibitory activity with IC50 values ranging between 49.93-

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Khan, Haroon, and Murad Ali Khan. "Antiulcer Effect of Extract/Fractions of Eruca sativa: Attenuation of Urease Activity." Journal of Evidence-Based Complementary & Alternative Medicine 19, no. 3 (2014): 176–80. http://dx.doi.org/10.1177/2156587214527452.

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Eruca sativa (Rocket salad) is known for its antiulcer properties in the traditional system of treatment. The present study was, therefore, designed to scrutinize its effect on urease activity in vitro. The results demonstrated marked attenuation of urease by the crude extract of various test concentrations with IC50 value of 7.77 mg/mL. On fractionation, marked change in inhibitory profile was observed. The ethyl acetate fraction was the most potent urease inhibitor with IC50 value of 4.17 mg/mL followed by the aqueous fraction with an IC50 value of 5.83 mg/mL. However, hexane did not show si

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Hanif, Muhammad, Khurram Shoaib, Muhammad Saleem, Nasim Hasan Rama, Sumera Zaib, and Jamshed Iqbal. "Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives." ISRN Pharmacology 2012 (August 13, 2012): 1–9. http://dx.doi.org/10.5402/2012/928901.

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A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluated in vitro for their urease inhibitory activities, most of the investigated compounds were potent inhibitors of Jack bean urease. The molecular docking studies were performed b

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Nayab, S., A. Alam, F. A. Khan, H. Khan, S. Khan, and F. A. Khan. "Synthesis, characterization and urease inhibitory activities of Zn(II) complexes bearing C1-symmetric ligands derived from (R)-phenylethanamine." Bulletin of the Chemical Society of Ethiopia 35, no. 2 (2021): 301–14. http://dx.doi.org/10.4314/bcse.v35i2.7.

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ABSTRACT. A series of Zn(II) complexes, supported with N-substituted phenylethanamine derivatives, [LnZnCl2] (where Ln = LA ((R)-1-phenyl-N-(thiophene-2-ylmethyl)ethanamine; LB (R)-N-(5-meyhylthiophene-2-yl)methyl-1-phenylethanamine; LC ((R)-N-(furan-2-ylmeththyl)-1-phenylethanamine and LD (R)-N-((5-methylfuran-2-yl)methyl)-1-phenylethanamine) were synthesized and characterized. The urease inhibitory activities of these complexes were determined against selected urease inhibitors where [LBZnCl2] was found to be the most prominent inhibitor of Jack bean urease (J. B. urease) (IC50 = 10.39±0.78

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