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Journal articles on the topic 'Uric acid Edo state'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

OSADOLOR, B. H., O. G. IGHARO, N. OLUMESE, and J. O. IDEMUDIA. "ANTIOXIDANT EFFECTS OF URIC ACID ON PATIENTS WITH TYPE-2 DIABETES MELLITUS IN NIGERIA." Nigerian Journal of Life Sciences (ISSN: 2276-7029) 3, no. 1 (2022): 154–58. http://dx.doi.org/10.52417/njls.v3i1.118.

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There is paucity of information on the antioxidant role of uric acid in the management of diabetic stress. This study seeks to elucidate the antioxidant usefulness of uric acid in type-2 diabetes mellitus patients visiting the Irrua Specialist Teaching Hospital, Irrua and Ekpoma environs of Edo state, Nigeria. Serum uric acid concentration was estimated in one hundred (100) subjects comprising of sixty (60) type 2 diabetic patients (30 males and 30 females) and forty (40) non-diabetic subjects (20 males and 20 females) using the enzymatic method (uricase). The non-diabetic individuals were app

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Osadolor, H., and J.C. Ihongbe. "EFFECT OF LEPROSY ON NON-ENZYMATIC ANTIOXIDANTS (VITAMIN C, VITAMIN E AND URIC ACID) IN (EDO STATE) NIGERIAN LEPROSY PATIENTS." Continental J. Biomedical Sciences 2 (June 18, 2008): 1–5. https://doi.org/10.5281/zenodo.820318.

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In the study being reported, the plasma levels of vitamin C, vitamin E and uric acid were determined in a total of 86 subjects comprised of 31 leprosy patients on multidrug therapy (MBT), 40 leprosy patients relieved from therapy (RFT) in Ossiomo leprosorium settlement and 15 normal individuals who served as control subjects. Of the MDT group, 10 subjects were paucibacillary (PB) lepers and 21 multibacillary (MB) lepers. The results obtained show that there were significant decreases in the plasma vitamin C and vitamin E (P<0.05) relative to the controls. However the uric acid was higher in

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3

Ajayi, Olulope. "Hepato-renal function assessments in apparently healthy undergraduate students of Edo State University Uzairue: A Pilot study." Journal of Current Biomedical Research 4, no. 5 (2024): 1858–68. https://doi.org/10.54117/jcbr.v4i5.6.

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The prevalence rates of chronic hepatic and renal diseases are increasing globally. Unhealthy lifestyle is a major contributor to the increasing prevalence rates. Due to the asymptomatic nature of these diseases at the early stages, diagnosis is not made early. Most studies have focused on study participants already diagnosed of these diseases; it is therefore imperative to carry out this study on apparently healthy undergraduate students who were predominantly adolescents with the view to identifying individuals at risk of these diseases. Fifty apparently healthy undergraduate students of Edo

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Zellelow, Amanuel Z., Kun-Hae Kim, Ryan E. Sours, and Jennifer A. Swift. "Solid-State Dehydration of Uric Acid Dihydrate." Crystal Growth & Design 10, no. 1 (2010): 418–25. http://dx.doi.org/10.1021/cg9010218.

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5

Angelo, Michele Carella. "Hyperuricemia and global Cardiovascular Risk: State of the art and preventive prospects." Archives of Preventive Medicine 2, no. 1 (2017): 022–27. https://doi.org/10.17352/apm.000008.

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Over the last years, scientific research has focused its interest on a potential role of hyperuricemia as cardiovascular risk factor; main interest has been directed to persistent raised plasma levels of uric acid. Although some studies have not shown a close correlation between hyperuricemia and cardiovascular risk, most scientific evidence agrees that hyperuricemia plays a key role in determining cardiovascular events and in development of other risk factors often associated with only moderately increased serum uric acid levels. Pathophysiological mechanism underlying this association mainly

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6

Housecroft, Catherine E. "What Goes in Must Come out: The Story of Uric Acid." CHIMIA 75, no. 10 (2021): 891. http://dx.doi.org/10.2533/chimia.2021.891.

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Birds and reptiles convert waste ammonia into uric acid, while mammals excrete urea, with only small amounts of uric acid ending up in urine. This column explores the varying roles of uric acid and important calcium and sodium salts, and introduces pi-stacking interactions in solid-state structures.

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7

Jung, Su Woong, Su-Mi Kim, Yang Gyun Kim, Sang-Ho Lee, and Ju-Young Moon. "Uric acid and inflammation in kidney disease." American Journal of Physiology-Renal Physiology 318, no. 6 (2020): F1327—F1340. http://dx.doi.org/10.1152/ajprenal.00272.2019.

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Asymptomatic hyperuricemia is frequently observed in patients with kidney disease. Although a substantial number of epidemiologic studies have suggested that an elevated uric acid level plays a causative role in the development and progression of kidney disease, whether hyperuricemia is simply a result of decreased renal excretion of uric acid or is a contributor to kidney disease remains a matter of debate. Over the last two decades, multiple experimental studies have expanded the knowledge of the biological effects of uric acid beyond its role in gout. In particular, uric acid induces immune

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8

Valigura, M. S. "HYPERURICEMIA INFLUENCE ON THE STATE OF PLATELET HEMOSTASIS IN PATIENTS WITH STAGE II HYPERTENSION." Ukrainian Scientific Medical Youth Journal 103, no. 4 (2017): 16–18. http://dx.doi.org/10.32345/usmyj.4(103).2017.16-18.

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The effect of uric acid on platelet hemostasis in patients with hypertension (HT) was studied. 80 patients with the HT I-II stage and 1-3 degrees of increased blood pressure was examined. Hyperuricemia was diagnosed with a uric acid level of>420 мmol/L. In order to study platelet hemostasis, an estimate of spontaneous aggregation of platelets and induced aggregation with adenosine diphosphate (ADP), arachidonic acid (AA), collagen, and adrenaline before and after cuff tests was performed. An assessment of endothelial dysfunction during cuff tests was also performed. Hyperaggregation was det

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Valigura, M. S. "HYPERURICEMIA INFLUENCE ON THE STATE OF PLATELET HEMOSTASIS IN PATIENTS WITH STAGE II HYPERTENSION." Ukrainian Scientific Medical Youth Journal 106, no. 2 (2018): 13–15. http://dx.doi.org/10.32345/usmyj.2(106).2018.13-15.

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The effect of uric acid on platelet hemostasis in patients with hypertension (HT) was studied. 80 patients with the HT I-II stage and 1-3 degrees of increased blood pressure was examined. Hyperuricemia was diagnosed with a uric acid level of>420 мmol/L. In order to study platelet hemostasis, an estimate of spontaneous aggregation of platelets and induced aggregation with adenosine diphosphate (ADP), arachidonic acid (AA), collagen, and adrenaline before and after cuff tests was performed. An assessment of endothelial dysfunction during cuff tests was also performed. Hyperaggregation was det

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10

Monisha M and Merriwin D. "Renal insufficiency in overt hypothyroidism." International Journal of Research in Pharmaceutical Sciences 11, SPL2 (2020): 13–15. http://dx.doi.org/10.26452/ijrps.v11ispl2.2053.

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Hypothyroidism is a common endocrine disorder worldwide. In hypothyroidism, there is altered regulation of renal hemodynamics and basal metabolic rate. This hospital-based case-control study was done to evaluate the changes in uric acid level in hypothyroid subjects. This study includes 25 hypothyroid cases with age and sex-matched controls. Serum total thyroid profile was estimated by ChemiluminiscenceImmunoassay (CLIA) and uric acid by the Uricase method in fully automated Vitros 5600. The mean uric acid level is increased in hypothyroid. Triiodothyronine(T3)&Thyroxine(T4)levelof hypothy

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Kroll, K., T. R. Bukowski, L. M. Schwartz, D. Knoepfler, and J. B. Bassingthwaighte. "Capillary endothelial transport of uric acid in guinea pig heart." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 2 (1992): H420—H431. http://dx.doi.org/10.1152/ajpheart.1992.262.2.h420.

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Much of the adenosine formed in the heart is degraded by endothelial enzymes to uric acid, which is exported across the coronary capillary endothelial cell membrane before renal excretion. Because previous experiments suggested that cell permeability for uric acid is either very high (similar to water) or very low, multiple indicator-dilution experiments were carried out to distinguish between the two possibilities. An intravascular reference tracer, 131I-labeled albumin, and an extracellular reference tracer, L-[3H]glucose, were injected together with [14C]uric acid as a bolus into the corona

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12

Eguvbe, A. O., E. B. George, D. F. Essiet, and H. E. Slater. "Evaluation of Serum Levels of Lipoprotein-A and Uric Acid and Their Correlation in Hypertensive Patients in Delta State, Nigeria." Journal of Applied Sciences and Environmental Management 28, no. 7 (2024): 2041–47. http://dx.doi.org/10.4314/jasem.v28i7.15.

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Lipoprotein (a) is an independent risk factor for cardiovascular disease. Also, elevated serum uric acid concentration is linked with an increased risk of cardiovascular disease. Therefore, the objective of this paper was to evaluate the serum levels of Lp (a) and uric acid and their correlation in hypertensive patients in Delta State, Nigeria. The study was conducted among 200 hypertensive and 100 normotensive individuals in a hospital-based cross-sectional investigation. Data obtained showed that one hundred and fifteen (57.5%) hypertensive and 15 (15%) normotensive controls had elevated pla

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Dr.Samarjit, Koner, and Arunima Chaudhuri Dr. "An Observational Cross Sectional Study to Evaluate the Effect of Thyroid Hypo Function on Serum Creatinine and Serum Uric Acid Levels to Assess the Renal Status in an Urban Hypothyroid Female Population of Reproductive Age Group in Eastern India." International Journal of Research and Review 6, no. 4 (2019): 161–69. https://doi.org/10.5281/zenodo.3989098.

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<strong>Background:</strong> Thyroid disorders are the most common worldwide and also in India. It is well documented that renal status such as elevated serum creatinine and serum uric acid levels are associated with hypothyroid state of the body. <strong>Aims:</strong> To investigate the effect of hypothyroid state on Serum Creatinine and Serum Uric acid levels in an urban female hypothyroid population of reproductive age group in Eastern India. <strong>Materials & methods:</strong> This present observational cross sectional study was conducted on 200 hypothyroid subjects i

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Joshi, Amrita, Andrew Kimball, Matthew Schaller, et al. "Modulation of Xanthine metabolism ameliorates inflammation and accelerates diabetic wound healing." Journal of Immunology 200, no. 1_Supplement (2018): 170.13. http://dx.doi.org/10.4049/jimmunol.200.supp.170.13.

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Abstract Wound healing in diabetic patients is impaired because of dysregulated innate immune response that results in a chronic inflammatory state. It has been shown by our group and others that metabolites can contribute to a state of chronic inflammation in diabetic tissues. In a murine model of Type-2 diabetes (diet-induced obese mice; DIO), we assessed role of uric acid in driving macrophage-mediated inflammation and delayed wound healing. Using liquid chromatography-mass spectrometry, we show that macrophages from DIO mice have reduced levels of xanthine, a precursor in the uric acid pat

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15

Salas, J. A., K. Johnstone, and D. J. Ellar. "Role of uricase in the triggering of germination of Bacillus fastidiosus spores." Biochemical Journal 229, no. 1 (1985): 241–49. http://dx.doi.org/10.1042/bj2290241.

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The likelihood that uric acid was the only compound capable of triggering germination of Bacillus fastidiosus spores was reinforced by the finding that ureidoglycollic acid, urea, NH4Cl, 2,8-dihydroxypurine and a combination of L-alanine and O-carbamoyl-D-serine were ineffective as germinants. Uric acid-triggered germination of B. fastidiosus was prevented by a range of inhibitors that also inhibited uricase activity in dormant spore extracts. O2 uptake during germination started immediately after addition of uric acid, possibly as a consequence of the oxidation of uric acid by the enzyme uric

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16

Halán, Miloš, Lucia Kottferová, Karol Račka, and Anthony Lam. "The Amount of Food Ingested and Its Impact on the Level of Uric Acid in the Blood Plasma of Snakes." Animals 12, no. 21 (2022): 2959. http://dx.doi.org/10.3390/ani12212959.

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In mammals, lipemic blood from sampling too soon after an animal feeds can have substantial effects on biochemical values. Plasma biochemical values in reptiles may be affected by species, age, season, and nutritional state. However, fasting status is not routinely considered when sampling reptile blood. Assessing uric acid levels in snakes is an important part of the diagnosis of the renal disease. However, the use of this biochemical indicator is undervalued without knowledge of natural uric acid fluctuations and the lack of differentiation from pathological changes. This study aimed to look

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17

Minyailova, N. N., Yu I. Rovda, Yu N. Shishkova, A. V. Vedernikova, O. V. Shmakova, and O. S. Zeleznyak. "RELATIONSHIPS BETWEEN HYPERHOMOCYSTEINEMIA AND THE FUNCTIONAL STATE OF THE KIDNEYS IN CHILDREN WITH IMPAIRED PURINE METABOLISM." Pediatria. Journal named after G.N. Speransky 101, no. 6 (2022): 30–36. http://dx.doi.org/10.24110/0031-403x-2022-101-6-30-36.

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Among the modified risk factors for chronic kidney disease hyperhomocysteinemia (HHC) and hyperuricemia (HU) play an important role in the development of the cardiorenal continuum. The purpose of the research was to study the relationship between HHC and the functional state of the kidneys in children with impaired purine metabolism. Materials and methods used: a single-center one-stage (cross-sectional) study was conducted in 54 pediatric patients aged 9 to 15 y/o with purine metabolism disorders (in the form of isolated HU or in combination with hyperuricosuria) in Feb. 2017 - March 2021. Th

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Arian, Mahnaz, Mina AkbariRad, Ahmad Bagheri Moghaddam, Abdollah Firoozi, and Mohammad Jami. "Allopurinol and Loss of Consciousness in a 78-old Year Man Suffering from Gout." Infectious Disorders - Drug Targets 20, no. 2 (2020): 253–56. http://dx.doi.org/10.2174/1871526519666190128102039.

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: Allopurinol is an FDA -Approved xanthine oxidase inhibitor, which is effective in the treatment of gout, hyperuricemia and uremic kidney stones in patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine into uric acid, and therefore its inhibition results in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction. Case Presentation: This report represents a case of drug-indu

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19

Abreu, M. C. A., R. C. Guimarães, and H. Krieger. "Serum uric acid levels in Chagas' disease." Memórias do Instituto Oswaldo Cruz 84, no. 2 (1989): 151–55. http://dx.doi.org/10.1590/s0074-02761989000200002.

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Uricemia was studied in a sample of 192 individuals from a highly endemic site for Chagas' disease (Bambuí, State of Minas Gerais, Brazil). The sample had serologically negative individuals (controls) and the positive ones were classified on the basis of the presence of electrocardiographic alterations (63), altered esophageal emptying (16), or without any sign on sympton of the disease (76). Only the individuals with the digestive form of chronic Chagas' disease showed hyperuricemia, when compared with the appropriate controls. Family data suggest that hyperuricemia is an effect of the digest

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Eraga, LI, E. Aganbi, AA Anigboro, SO Asagba, and NJ Tonukari. "Antigenotoxicity and antioxidant activities of bitter leaf (Vernonia amygdalina del.) accessions from different parts of Nigeria." African Journal of Food, Agriculture, Nutrition and Development 22, no. 4 (2022): 20161–80. http://dx.doi.org/10.18697/ajfand.109.20355.

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Bitter leaf (Vernonia amygdalina Del.) plant is a tree species that is highly cultivated in Nigeria for its nutritive and therapeutic values. This study aimed to determine the antioxidant and antigenotoxicity effects (in vitro) of 52 accessions of V. amygdalina collected from six geopolitical zones of Nigeria (North East, North West, North Central, South South, East and West) by evaluating the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO-) scavenging antioxidant activities, flavonoid and phenolic contents as well as ethidium bromide-induced DNA (deoxyribonucleic acid) damage of bi

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Țăpoi, Laura, Delia Lidia Șalaru, Radu Sascău, and Cristian Stătescu. "Uric Acid—An Emergent Risk Marker for Thrombosis?" Journal of Clinical Medicine 10, no. 10 (2021): 2062. http://dx.doi.org/10.3390/jcm10102062.

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Hyperuricemia is nowadays an established cardiovascular risk factor. Experimental studies linked elevated serum uric acid (SUA) levels with endothelial dysfunction (ED), inflammation, and prothrombotic state. The purpose of this review is to summarize the current evidence that emphasizes the possible role of uric acid as a biomarker for a prothrombotic state. A large number of clinical trials correlated SUA levels with both incident and recurrent cases of venous thromboembolism (VTE), independent of other confounding risk factors. Moreover, increased SUA levels may be an important tool for the

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Coelho, Mariana O. C., Alistair J. Monteyne, Ishara D. Kamalanathan, et al. "Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults." Nutrients 12, no. 4 (2020): 1115. http://dx.doi.org/10.3390/nu12041115.

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Circulating uric acid concentrations have been linked to various metabolic diseases. Consumption of large boluses of nucleotides increases serum uric acid concentrations. We investigated the effect of a nucleotide-rich mixed meal on postprandial circulating uric acid, glucose, and insulin responses. Ten healthy adults participated in a randomised, controlled, double-blind, crossover trial in which they consumed a mixed-meal containing either nucleotide-depleted mycoprotein (L-NU) or high-nucleotide mycoprotein (H-NU) on two separate visits. Blood samples were collected in the postabsorptive st

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Popovych, Igor, Igor Bombushkar, Nataliya Badiuk, Inna Korda, Walery Zukow, and Anatoliy Gozhenko. "Features of the state of neuro-endocrine factors of adaptation under different options of uric acid metabolism in healthy female rats." Journal of Education, Health and Sport 10, no. 3 (2020): 352–62. http://dx.doi.org/10.12775/jehs.2020.10.03.038.

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Background. As part of the project "Physiological activity of uric acid", we previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immunity parameters, which to one degree or another correlate with uricemia and uricosuria. The aim of this study was to identify autonomic and endocrine adaptogenic factors, the combination of which differentiates previously formed quantitative and qualitative variants of uric acid metabolism in rats. Materials and Methods. Experiment was perfor

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Crișan, Tania O., Maartje C. P. Cleophas, Marije Oosting, et al. "Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra." Annals of the Rheumatic Diseases 75, no. 4 (2015): 755–62. http://dx.doi.org/10.1136/annrheumdis-2014-206564.

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ObjectivesThe study of the proinflammatory role of uric acid has focused on the effects of its crystals of monosodium urate (MSU). However, little is known whether uric acid itself can directly have proinflammatory effects. In this study, we investigate the priming effects of uric acid exposure on the cytokine production of primary human cells upon stimulation with gout-related stimuli.MethodsPeripheral blood mononuclear cells (PBMCs) were harvested from patients with gout and healthy volunteers. Cells were pretreated with or without uric acid in soluble form for 24 h and then stimulated for 2

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Ara, Shahin, Taslima Nigar, and Md Anwar Habib. "Biomarkers of Oxidative Stress in Normal and Pre-eclamptic Women." KYAMC Journal 4, no. 2 (2017): 406–8. http://dx.doi.org/10.3329/kyamcj.v4i2.32280.

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Preeclampsia is a serious pregnancy complication. Little is known about which clinical risk factors are associated with the progression from normal to preeclampsia. Recent evidence suggests that the oxidative stress is one of the important factor associated with preeclampsia. High uric acid and MDA levels are indicative of oxidative stress. The purpose of this study was to evaluate the possible relationship between the biochemical markers (Uric acid & MDA) of oxidative stress in preeclamptic & normal pregnant women. In our study we investigated total number of 40 healthy pregnant and c

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Samuel, Echioda, Salisu Salisu, Abdulraheed Amina, Babai Mahdi, Judith Omogbeme, and Rita Sule Hadiza. "Variations on the Physiochemical, Microbiological and Selected Heavy Metals of Different Palm Oil Samples Sourced from Galadima, Tarauni, Sabon-Gari, Yan-Kura of Kano State and Samples from Kogi and Edo States of Nigeria." Chemistry Research Journal 5, no. 6 (2020): 189–94. https://doi.org/10.5281/zenodo.13148494.

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<strong>Abstract </strong>This study involves the physiochemical, microbiological and selected heavy metals variations of palm oil samples sourced from <em>galadima, tarauni, yan-kura</em> markets of kano State and samples from Kogi and Edo States of Nigeria. The samples were evaluated using standard documented procedures. The result showed; samples from Edo had: oil acid value 0.73±0.13, iodine value 29.25±0.09, peroxides value 2.68±0.09, saponification value 194.31±2.21, moisture content 1.13±0.56, ester value 195.04±2.08. The samples from Kogi had;

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Chernyaeva, A. O., M. R. Mykytyuk, and Yu I. Karachentsev. "Analysis of parameters of purine metabolism in patients with diabetes mellitus type 2." Medicni perspektivi 28, no. 4 (2023): 4–12. http://dx.doi.org/10.26641/2307-0404.2023.4.293972.

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The aim of this research is to comprehensively analyze the current state of purine metabolism as well as assess its features in patients with diabetes mellitus type 2, taking into account the clinical and metabolic polymorphism of the disease. The authors examined 327 patients with diabetes mellitus type 2 (144 men and 183 women), a group of individuals with an average age of 57.8±10.1 years. The average duration of the disease was (9.3±7.3) years. All subjects received oral hypoglycemic therapy. The researchers determined anthropometric indicators, indicators of carbohydrate metabolism, conce

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Chernyaeva, A.O., M.R. Mykytyuk, and Yu.I. Karachentsev. "Analysis of parameters of purine metabolism in patients with diabetes mellitus type 2." Medicni perspektivi 28, no. 4 (2023): 4–12. https://doi.org/10.26641/2307-0404.2023.4.293972.

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The aim of this research is to comprehensively analyze the current state of purine metabolism as well as assess its features in patients with diabetes mellitus type 2, taking into account the clinical and metabolic polymorphism of the disease. The authors examined 327 patients with diabetes mellitus type 2 (144 men and 183 women), a group of individuals with an average age of 57.8±10.1 years. The average duration of the disease was (9.3±7.3) years. All subjects received oral hypoglycemic therapy. The researchers determined anthropometric indicators, indicators of carbohydrate met

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MA. Naji, Zahraa, Shaimaa M.Mohammed, and Mays F. Muhammad. "Uric Acid as a Natural Scavenger of Peroxynitrite in a Sample of Iraqi Patients with Rheumatoid Arthritis." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 2 (2017): 51–55. http://dx.doi.org/10.31351/vol21iss2pp51-55.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with decreased antioxidant state .This study aim to investigate the status of oxidant/antioxidant in a sample of Iraqi patients with RA and the role of peroxynitrite and its natural scavenger uric acid in them .This case-controlled study was conducted at Baghdad teaching hospital /Baghdad from December 2010-May 2011 . Twenty-five patients with mean age 39 years and 25 apparently healthy subject as controls with mean age 29 years were included in the study .Investigations include estimation of serum levels of nitric oxide (N

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Maya savira. "Association of Uric Acid Level and Body Mass Index in Type 2 Diabetes Mellitus Patients." Journal of Saintech Transfer 3, no. 1 (2020): 71–76. http://dx.doi.org/10.32734/jst.v3i1.3957.

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Body Mass Index (BMI) or formerly called Quetelet Index is the measurement for scoring nutrient state in adults by using body weight (in kilogram) and body height (in metre). Obesity and overweight are defined as an abnormality of fat accumulation that can damage our health. Uric acid is a substance that is formed when the breaking process of purine occur. Hyperuricemia are condition that are closely related with gout. Uric acid level increased significantly towards those having obesity. It is also concluded that obesity was the usual cause in patients with recurrent gout attack. Strong relati

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DUBETSKA, H. S., and E. Y. SKLYROV. "Systemic osteoporosis and osteopenia in men with hyperuricemia." Experimental and Clinical Physiology and Biochemistry 97, no. 3 (2023): 42–51. http://dx.doi.org/10.25040/ecpb2023.03.042.

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The article presents the results of own research on the study of the incidence of osteoporosis and osteopenia in men with different levels of uric acid and the influence of hyperuricemia on the mineral density of bone tissue. The aim of the study was to examine the structural and functional state of bone tissue (indicators of mineral density) in men with different levels of uric acid and to establish the incidence of osteoporosis and osteopenia in patients with hyperuricemia. Materials and methods of research. 140 men aged 50–80 years were examined. Determination of the level of uric acid in t

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Maltsev, S. V., V. M. Davydova, and E. I. Zemlyakova. "Clinic and diagnosis of metabolic nephropathies in children." Kazan medical journal 67, no. 5 (1986): 358–60. http://dx.doi.org/10.17816/kazmj70701.

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We examined 70 patients with metabolic nephropathy (51 with oxaluria predominance, 19 with uric acid metabolism disorders). Distribution of patients into groups was carried out according to the results of multistage research, including analysis of pedigree; repeated biochemical studies, clinical and radiological comparisons. Endogenous creatinine clearance, residual nitrogen level, urea in blood, acid-base balance were determined to characterize the functional state of the kidneys. Renal tubular function was assessed by urinary excretion of calcium, phosphates, amino acids, titratable acids, Z

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Olotu, Y., D. Elamah, I. Yusuf, I.N. Gimba, and A.J. Arohunmolase. "Mineral Exploitation and Environmental Consequences in Edo State, Nigeria." European Journal of Advances in Engineering and Technology 10, no. 5 (2023): 46–52. https://doi.org/10.5281/zenodo.10636701.

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<strong>ABSTRACT </strong> The economic growth of Edo State has greatly benefited from the extraction of solid minerals. Numerous people engage in it as a source of income because it is one of the State's sources of foreign exchange. However, it has been discovered that there are numerous difficulties associated with the extraction and processing of solid minerals as a result of improper mining and exploitative operations utilizing convectional techniques, which have severely damaged the environment and ecology. The air quality (AQ) in the mining region has largely been polluted, and the value

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Jamshidi, Neema, Kabir B. Nigam, and Sanjay K. Nigam. "Loss of the Kidney Urate Transporter, Urat1, Leads to Disrupted Redox Homeostasis in Mice." Antioxidants 12, no. 3 (2023): 780. http://dx.doi.org/10.3390/antiox12030780.

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High uric acid is associated with gout, hypertension, metabolic syndrome, cardiovascular disease, and kidney disease. URAT1 (SLC22A12), originally discovered in mice as Rst, is generally considered a very selective uric acid transporter compared to other closely-related kidney uric acid transporters such as OAT1 (SLC22A6, NKT) and OAT3 (SLC22A8). While the role of URAT1 in regulating human uric acid is well-established, in recent studies the gene has been linked to redox regulation in flies as well as progression of renal cell carcinoma. We have now identified over twenty metabolites in the Ur

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Ren, Lu, Shangshang Wang, Shiting Liu, et al. "Postbiotic of Pediococcus acidilactici GQ01, a Novel Probiotic Strain Isolated from Natural Fermented Wolfberry, Attenuates Hyperuricaemia in Mice through Modulating Uric Acid Metabolism and Gut Microbiota." Foods 13, no. 6 (2024): 923. http://dx.doi.org/10.3390/foods13060923.

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Hyperuricaemia (HUA) is a disorder of purine metabolism, which manifests itself as an increase in uric acid production and a decrease in uric acid excretion, as well as a change in the structure of the intestinal microbiota. Most of the drugs currently used to treat HUA have significant side effects, and it is essential to find a treatment for HUA that is free of side effects. In this study, a novel strain, Pediococcus acidilactici GQ01, was screened from natural fermented wolfberry. The effects of both live bacteria GQ01 and its heat-killed G1PB postbiotic on HUA were investigated. The result

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Susanti, Nila, Yosi Sri Astuti, and Harlyanti Muthma'innah Mashar. "Literatur Review: Peran konseling gizi dan senam ergonomik dalam menurunkan kadar asam urat pada penderita gout." AcTion: Aceh Nutrition Journal 7, no. 2 (2022): 240. http://dx.doi.org/10.30867/action.v7i2.628.

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Gout is a disorder caused by inflammation of the joints due to the deposition of uric acid crystals stored in the joints. The causative factors are age, excessive purine intake, obesity, alcoholic beverages, and lack of physical activity. Various efforts can be made to overcome this, including nutritional counseling and physical activity, such as gymnastics. The study aims to provide descriptive information regarding the effect of nutritional counseling on a low-purine diet and ergonomic gymnastics in reducing uric acid levels in patients with gout. Literature review research was conducted usi

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Lumintang, Cyntia. "PENDIDIKAN KESEHATAN UNTUK MENGONTROL KADAR ASAM URAT PADA PENDERITA GOUT ARTHRITIS." Lasallian Abdimas: Jurnal Pengabdian kepada Masyarakat 2, no. 1 (2022): 17–21. http://dx.doi.org/10.52159/jla.v2i1.16.

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Gout arthritis is a metabolic disorder that attacks the joints, causing inflammation and pain. A person in this condition can experience limitations in activities, even affecting their mental state because they cannot carry out their role, thus impacting the quality of life of sufferers of gout arthritis. Health education about efforts to control uric acid levels so that gout arthritis does not occur or experience a relapse can increase people's knowledge and attitudes so that changes in good behavior can occur. This health education activity aims to increase the knowledge and attitudes of the

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Dasegowda, Shashikala Magadi, Ashok Kumar Jeppu, Sushith, and Kavitha Ashok Kumar. "Relation of Serum Adenosine Deaminase to Some Risk Factors in Type 2 Diabetes Mellitus." Journal of Health Science Research 1, no. 1 (2016): 13. http://dx.doi.org/10.18311/jhsr/2016/v1/i1/4726.

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<strong>Aim</strong>: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus. <strong>Materials and Method</strong>: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose. <st

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Bombushkar, Igor, Anatoliy Gozhenko, Inna Korda, Nataliya Badiuk, Walery Zukow, and Igor Popovych. "Features of the exchange of electrolytes and nitrogenous metabolites under different options of uric acid exchange in healthy female rats." Journal of Education, Health and Sport 10, no. 4 (2020): 405–15. http://dx.doi.org/10.12775/jehs.2020.10.04.043.

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Background. We previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immune, autonomic and endocrine parameters, which correlate with uricemia and uricosuria. The aim of this study was to identify the electrolytes and nitrogenous metabolites, the combination of which differentiates previously formed quantitative and qualitative variants of uric acid metabolism in rats. Materials and Methods. Experiment was performed on 60 healthy female Wistar rats 220-300 g. The plasma and

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Zinellu, Angelo, and Arduino A. Mangoni. "A Systematic Review and Meta-Analysis of the Association between Uric Acid and Allantoin and Rheumatoid Arthritis." Antioxidants 12, no. 8 (2023): 1569. http://dx.doi.org/10.3390/antiox12081569.

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Alterations in the circulating concentrations of uric acid and its degradation product, allantoin, might account for the systemic pro-oxidant state and the increased cardiovascular risk in rheumatoid arthritis (RA). We sought to address this issue by conducting a systematic review and meta-analysis of the association between the plasma/serum concentrations of uric acid and allantoin and RA. We searched PubMed, Scopus, and Web of Science from inception to 20 June 2023 for studies comparing plasma/serum concentrations of uric acid and allantoin between RA patients and healthy controls. We assess

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Sholan, Rashad, Rufat Aliyev, Ulduz Hashimova, Seymur Karimov, and Elvin Bayramov. "Urinary Stone Composition Analysis of 1465 Patients: The First Series from Azerbaijan." Archives of Iranian Medicine 27, no. 11 (2024): 618–23. http://dx.doi.org/10.34172/aim.32026.

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Background: Urinary stone disease is a prevalent health issue worldwide, with varying incidence influenced by multiple factors. This study aims to provide the first comprehensive analysis of urinary stone composition in Azerbaijan. Methods: A retrospective study was conducted on 1465 patients, aged 1‒83 years, who underwent biochemical urinary stone analysis at the Department of Renal Diseases and Organ Transplantation, Azerbaijan State Security Service Military Hospital, between April 2015 and December 2023. Stone samples were analyzed using Fourier transform infrared (FTIR) spectroscopy. Sta

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Wahyudi, Nizar, I. Wayan Getas, Ida Bagus Wiadnya, and Lalu Srigede. "Description of Uric Acid Levels and Blood Pressure In Pulmonary Tuberculosis Patients Consuming Anti Tuberculosis Drug (ATD) in the Working Area of Sakra Public Health Center." Jurnal Analis Medika Biosains (JAMBS) 10, no. 1 (2023): 37. http://dx.doi.org/10.32807/jambs.v10i1.302.

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Background: Anti-tuberculosis (ATD) used is the standard blend of INH, PAS and streptomycin for one to two years. The amino salylic (pas) acids are then replaced with pirazinacids. Pirazinbacteria is a drug that can cause increased levels of uric acid in the body (hyacinth). Hiperurisemia is the state of concentration of the veins in the plasma or the serum has exceeded the limit of the monosodium ligament of 7.0 milligrams /dl. Hyperuricemia is also cited as an important risk factor for hypertension and other cardiovascular diseases. Research purposes: For details of uric acid and blood press

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Catarino, Cristina, Alice Santos-Silva, Luís Belo, et al. "Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood." Journal of Pregnancy 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/684384.

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Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity. PE is associated with an inflammatory state and with oxidative stress, in maternal circulation. Our aim was to evaluate and compare the levels of oxidative stress and inflammatory markers in maternal and umbilical cord blood (UCB), in normal and PE pregnancies. We measured acute-phase proteins (CRP and α1-antitrypsin), proinflammatory cytokines (IL-6 and TNF-α), leukocyte activation (elastase, lactoferrin, sL-selectin, sVCAM, sPECAM), total antioxidant status (TAS), thiobarbituric acid reactive substance

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He, Haoxuan, Hui Zeng, Yongming Fu, et al. "A self-powered electronic-skin for real-time perspiration analysis and application in motion state monitoring." Journal of Materials Chemistry C 6, no. 36 (2018): 9624–30. http://dx.doi.org/10.1039/c8tc03296c.

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Gawlik, K., J. W. Naskalski, D. Fedak, et al. "Markers of Antioxidant Defense in Patients with Type 2 Diabetes." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/2352361.

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Aims. Diabetes is considered a state of increased oxidative stress. This study evaluates blood concentrations of selected markers of antioxidant defense in patients with type 2 diabetes.Methods. The study included 80 type 2 diabetes patients and 79 apparently healthy controls. Measured markers included ferric reducing ability of plasma (FRAP), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR),γ-glutamyltransferase (GGT) and uric acid serum, and plasma and/or hemolysate levels.Results. FRAP, uric acid, CRP, and GGT levels were significantly higher in patients w

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SOLOMON, M. UVOH, A. AZIBALUA ASARA, and NGAIKEDI NNAMDI CHARLES. "EFFECT OF CONTAMINATED AIR ON RENAL INDICES OFNON-PREGNANT WOMEN IN BAYELSA STATE NIGERIA." GPH-International Journal of Biological & Medicine Science 05, no. 05 (2021): 01–08. https://doi.org/10.5281/zenodo.6778250.

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This study determines some renal parameters of non-pregnant women exposed to polluted air and ascertains whether the increase in renal dysfunction is linked to the indiscriminate gas flares in Bayelsa state. A random sampling technique was used in this study. Participants within the ages of31-40 years of age had a non-significant higher uric acid concentration (4.03mg/dl) compared with age 41-50 (2.53mg/dl), age 21-30 had a significant increased urea (3.44mmol/l) compared to age 31-40 (3.41mmol/l) and 41-50 (3.06mmol/l).Creatinine concentration was significantly higher among age 31-40 (93.29&m

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Jun, Pang, Huang Bo-ling, Li Yu-shun, Zhou Yu-yan, Han Zhi-yong, and Faye Richardson. "Treatment of Gout with Acupuncture." Acupuncture in Medicine 18, no. 1 (2000): 29–31. http://dx.doi.org/10.1136/aim.18.1.29.

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Gout is a disorder of purine metabolism in which a high serum uric acid is found and there is deposit of urate crystals within joints causing exquisite pain and tenderness. The pharmacological treatment relies upon non-steroidal anti-inflammatory drugs in the acute stage, and prophylactic drugs in the chronic state to control the level of circulating uric acid. In traditional Chinese medicine an over-rich diet is thought to cause a build-up of damp and heat internally that causes phlegm to stagnate. There is also disturbance of the Spleen and Kidney. Treatment thus involves Spleen and Stomach

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Bi, Yun-Shuai, Bo Liu, Xu-Ying Liu, Ying Qin, and Ben-Xue Zou. "A h-BCN for Electrochemical Sensor of Dopamine and Uric Acid." Journal of Nanomaterials 2020 (January 16, 2020): 1–9. http://dx.doi.org/10.1155/2020/4604820.

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A hexagonal boron carbon nitride hybrid (h-BCN) is developed by in situ high-temperature solid-state reaction and subsequent chemical reduction with hydrazine. The XRD and TEM results show that the h-BCN features interlayered structures with two characteristic d-spacing of 0.33 and 0.21 nm. The obtained h-BCN exhibits significant electrochemical sensor for dopamine and uric acid. The cyclic voltammetric and amperometric experiments revealed a good linear relationship between current densities and concentrations of dopamine (DA) of 10-300 μM and uric acid (UA) of 10-500 μM, with high sensitivit

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Bombushkar, Igor. "Features of the state of the neuroendocrine-immune complex and electrolyte-nitrogenous exchange under different variations of uric acid metabolism in female rats." Journal of Education, Health and Sport 10, no. 5 (2020): 410–21. http://dx.doi.org/10.12775/jehs.2020.10.05.044.

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Background. This article concludes the experimental part of the project "Physiological activity of uric acid". Our group previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immune, autonomic and endocrine parameters as well as plasma and urine electrolytes and nitrogenous parameters, which to one degree or another correlate with uricemia and uricosuria. Because the autonomic, endocrine and immune parameters interact with each other within the neuro-endocrine-immune complex

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Fenech, Goël, Gérald Rajzbaum, Mikaël Mazighi, and Jacques Blacher. "Serum uric acid and cardiovascular risk: State of the art and perspectives." Joint Bone Spine 81, no. 5 (2014): 392–97. http://dx.doi.org/10.1016/j.jbspin.2014.01.008.

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