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Journal articles on the topic 'Uridine compounds'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Berrío Escobar, Jhon Fernando, Victor Hugo Arango Carmona, Elkin Galeano Jaramillo, et al. "Synthesis and cytotoxic activity of tri-acyl ester derivatives of uridine in breast cancer cells." Ars Pharmaceutica (Internet) 57, no. 4 (2016): 183–91. http://dx.doi.org/10.30827/ars.v57i4.5560.

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Aims: Synthesize tri-acyl ester derivatives of uridine, and evaluate its cytotoxicity against breast cancer cells line. Methods: The tri-esterified uridine derivatives were obtained through Steglich esterification reaction by fatty and aromatic acids, and with acetic anhydride. An acetonide derivative from uridine was prepared with acid catalysis. Compounds were characterized by NMR spectroscopy (1H NMR and 13C NMR), and mass spectrometry. Derivatives were assessed in chinese hamster ovary (CHO-K1) and human breast cancer (MCF-7) cell lines. Results: Five tri-acyl ester derivatives of uridine

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2

Postolache, Cristian, George Bubueanu, Catalin Stelian Tuta, and Andi Sebastian Cucoanes. "SYNTHESIS OF TRITIUM LABELLED THYMIDINE AND URIDINE." SMART ENERGY AND SUSTAINABLE ENVIRONMENT 25, no. 1 (2022): 47–54. http://dx.doi.org/10.46390/j.smensuen.25122.447.

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This study present tritium labeling methods for uridine and thymidine in the methyl position. The synthesis of tritiated thymidine has been performed using two different methods: catalytic hydrogenation of brominated derivative and respectively of hydroxymethyl deoxiuridine. The tritiated uridine has been synthesized by catalytic hydrogenation of 5-I Uridine. The labelled compounds were purified by Thin Layer Chromatography and characterized by determination of radioactive concentration, chemical concentration and radiochemical purities. The obtained tritiated thymidine and uridine have been u

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3

Berrio Escobar, Jhon, MH Pastrana Restrepo, E. Galeano Jaramillo, DM Márquez Fernández, ME Márquez Fernández, and A. Martínez Martínez. "Synthesis and cytotoxic activity of per-acetylated and halogenated derivatives of nucleosides in breast cancer cells." Ars Pharmaceutica (Internet) 58, no. 4 (2017): 145–54. http://dx.doi.org/10.30827/ars.v58i4.6441.

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Objectives. To make the synthesis of halogenated derivatives on the nitrogenous base and their respective acyl ester and amide type derivatives for all hydroxyl and amine groups of the uridine and cytarabine nucleosides, and evaluate cytotoxicity against breast cancer cell line. Methods. First, it was accomplished the halogenation reaction on the 5-position of the nitrogenous base, subsequently, the ester and amide derivatives were performed for all hydroxyl and amine group present in the nucleosides. Besides, the uridine acetonide derivatives as prepared by acid catalysis. The products were c

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4

König, Helmut, Otto Kandler, and Walter Hammes. "Biosynthesis of pseudomurein: isolation of putative precursors from Methanobacterium thermoautotrophicum." Canadian Journal of Microbiology 35, no. 1 (1989): 176–81. http://dx.doi.org/10.1139/m89-027.

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In aqueous trichloroacetic acid extracts of Methanobacterium thermoautotrophicum the following compounds, which are supposed to be precursors in the biosynthesis of the glycan strand of the pseudomurein, were isolated and identified: (i) a disaccharide (compound II) composed of uridine 5′-diphosphate, N- acetylglucosamine and N-acetyltalosaminuronic acid with N-acetylglucosamine at the reducing end, (ii) uridine 5′-diphospho-N-acetylglucosamine, and (iii) uridine 5′-diphospho-N-acetylgalactosamine. However, the corresponding monomeric derivative of N-acetyltalosaminuronic acid could not be det

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5

Maowa, Jannatul, Asraful Alam, Kazi M. Rana, et al. "Synthesis, characterization, synergistic antimicrobial properties and molecular docking of sugar modified uridine derivatives." Ovidius University Annals of Chemistry 32, no. 1 (2021): 6–21. http://dx.doi.org/10.2478/auoc-2021-0002.

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Abstract Nucleosides and their analogues are an important, well-established class of clinically useful medicinal agents that exhibit antiviral and anticancer activity. Thus, our research group has focused on the synthesis of new nucleoside derivatives that could be tested for their broad-spectrum biological activity. In this study, two new series of nucleoside derivatives were synthesized from uridine (1) through facile two-step reactions using the direct acylation method, affording 5’-O-acyl uridine derivatives in good yields. The isolated uridine analogs were further transformed into two ser

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6

Munia, Nasrin S., Mohammed M. Alanazi, Youness El Bakri, et al. "Uridine Derivatives: Synthesis, Biological Evaluation, and In Silico Studies as Antimicrobial and Anticancer Agents." Medicina 59, no. 6 (2023): 1107. http://dx.doi.org/10.3390/medicina59061107.

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Nucleoside analogs are frequently used in the control of viral infections and neoplastic diseases. However, relatively few studies have shown that nucleoside analogs have antibacterial and antifungal activities. In this study, a fused pyrimidine molecule, uridine, was modified with various aliphatic chains and aromatic groups to produce new derivatives as antimicrobial agents. All newly synthesized uridine derivatives were analyzed by spectral (NMR, FTIR, mass spectrometry), elemental, and physicochemical analyses. Prediction of activity spectra for substances (PASS) and in vitro biological ev

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7

Bulbul, Md Z. H., Tasneem S. Chowdhury, Md M. H. Misbah, et al. "Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents." Pharmacia 68, no. (1) (2021): 23–34. https://doi.org/10.3897/pharmacia.68.e56543.

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Nucleoside derivatives are important therapeutic drugs and are the focal point in the ongoing search for novel, more potent drug targets. In this study, a new series of pyrimidine nucleoside i.e., uridine (1) derivatives were synthesized via direct method and evaluated for their antimicrobial potential activity. The title compound uridine (1) was treated with triphenylmethyl chloride in pyridine to give the 5´-O-(triphenylmethyl)uridine derivative (2), which was subsequently derivatized to create a series of 2´,3´-di-O-acyl analogs containing a wide variety of functionalities in a single molec

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8

Xue, Ying, Wei Jin, Xian-Shun Xu, et al. "Quality Evaluation of Tricholoma matsutake based on the Nucleic Acid Compounds by UPLC-TOF/MS and UPLC-QqQ/MS." Molecules 24, no. 1 (2018): 34. http://dx.doi.org/10.3390/molecules24010034.

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So far, there has been no quality evaluation of Tricholoma matsutake. Nucleic acid compounds are a kind of functional ingredient in T. matsutake that is beneficial to human health. In this study, a UPLC-TOF/MS method was first used to scan and identify the potential nucleic acid compounds in T. matsutake. Based on the calculation of the molecular formula and subsequent confirmation by authentic standards, 15 nucleic acid compounds were unambiguously identified: adenosine, cytidine, guanosine, inosine, thymidine, uridine, xanthosine dehydrate, 2′-deoxyadenosine, 2′-deoxycytidine, 2′-deoxyguanos

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9

Kayed, Akram M., EL Sayed M. Elghaly, and Atef A. El-Hela. "New Epoxy Megastigmane glucoside from Dactyloctenium aegyptium L.P.Beauv Wild (Crowfootgrass)." Journal of Scientific and Innovative Research 4, no. 6 (2015): 237–44. http://dx.doi.org/10.31254/jsir.2015.4605.

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Phytochemical investigation of Dactyloctenium aegyptium L. Wild herbrevealed the isolation and identification of three new compounds5-hydroxypyrimidine- 2,4 (3H,5H)- dione [6],6'Glyceryl asysgangoside[8],and 2 amino, 2 methyl,(5,6 di hydroxymethyl ), 1,4 dioxane [11]were isolated for the first time from nature in addition tonine known compounds, P.hydroxy benzaldhyde[1], tricin [2],P.hydroxy benzoic acid[3], vanillic acid [4], β-sitosterol-3-O-β-D-glucoside [5], asysgangoside[7] adenine[9], uridine[10] and sucrose[12]The structural elucidations of isolated compounds were established on the bas

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10

Bulbul, Md Z. H., Tasneem S. Chowdhury, Md M. H. Misbah, et al. "Synthesis of new series of pyrimidine nucleoside derivatives bearing the acyl moieties as potential antimicrobial agents." Pharmacia 68, no. 1 (2021): 23–34. http://dx.doi.org/10.3897/pharmacia.68.e56543.

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Nucleoside derivatives are important therapeutic drugs and are the focal point in the ongoing search for novel, more potent drug targets. In this study, a new series of pyrimidine nucleoside i.e., uridine (1) derivatives were synthesized via direct method and evaluated for their antimicrobial potential activity. The title compound uridine (1) was treated with triphenylmethyl chloride in pyridine to give the 5´-O-(triphenylmethyl)uridine derivative (2), which was subsequently derivatized to create a series of 2´,3´-di-O-acyl analogs containing a wide variety of functionalities in a single molec

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11

Dao, Duc Thien, Quoc Thang Le, and Thanh Tam Nguyen. "Nitrogen-containingheterocycliccompounds from the roots of Callerya speciosa." Ministry of Science and Technology, Vietnam 64, no. 3 (2022): 49–52. http://dx.doi.org/10.31276/vjste.64(3).49-52.

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The four nitrogen-containing heterocyclic compounds uridine (1), 2-(β-D-glucopyranosyl)-3-isoxazolin-5-one (2), adenosine (3), and hypaphorine (4) were isolated from the n-butanol extract of the roots of Callerya speciosa. Their structures were characterized on the basis of extensive nuclear magnetic resonane (NMR), mass spectroscopic analyses, and comparison with reported values. This is the first report on the isolation of compounds 1-4 from Callerya speciosa.

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12

Stachowiak, Klaudia, Michal Zabiszak, Jakub Grajewski, Anna Teubert, Anna Bajek, and Renata Jastrzab. "Thermodynamic Studies of Complexes in Cu(II)/Uridine-5′-Diphosphoglucuronic Acid System." Molecules 29, no. 15 (2024): 3695. http://dx.doi.org/10.3390/molecules29153695.

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A binary system of uridine-5′-diphosphoglucuronic acid with copper (II) ions was studied. Potentiometric studies in aqueous solutions using computer data analysis were carried out. The pH of dominance, the overall stability constants (logβ), and the equilibrium constants of the formation reaction (logKe) were determined for each complex compound formed in the studied system. Spectroscopic studies were carried out to determine the mode of coordination in the compounds studied. Cytotoxicity and metabolic activity tests of the compounds obtained showed an increase in the biological activity of th

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13

Jenan, Mohammed Ubaid, Fauzi Al-Rubaye Abeer, and Hadi Hameed Imad. "Analysis of Bioactive Chemical Compounds of Trogoderma granarium (Insecta: Coleoptera: Dermestidae) Using Gas Chromatography – Mass Spectrometry." International Journal of Toxicological and Pharmacological Research 9, no. 3 (2017): 199–205. https://doi.org/10.5281/zenodo.12698026.

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Methanolic extract of bioactive compounds of <em>Trogoderma granarium</em> was assayed. GC-MS analysis of <em>Trogoderma granarium</em> revealed the existence of the Pentanoic acid , 1,1-dimethylpropyl ester , (1H)-Pyrimidinone , 5-chloro-4,6-diphenyl, Cyclobutanemethanol , α-methyl- , Nitro-2-methyl-1,3-propanediol , Hydroxylamine ,O-(2-methylpropyl)- , Uridine , 2′,3′-O-(phenylmethylene)- ,Acetic acid ,2-benzoylthio-,2-oxo-2-phenylethyl ester , methylpropyl)- , Uridine , 2′,3′-O-(phenylmethylene)- , 5′-(4-methylbenzenesulfo , Indolinol

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14

Gerstin, Karin M., Mark J. Dresser, and Kathleen M. Giacomini. "Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT." American Journal of Physiology-Renal Physiology 283, no. 2 (2002): F344—F349. http://dx.doi.org/10.1152/ajprenal.00274.2001.

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To understand the roles that nucleoside transporters play in the in vivo distribution of clinically important nucleoside analogs, the substrate specificity of each transporter isoform should be determined. In the present work, we studied the substrate specificities of the human and rat orthologs of the Na+-dependent purine-selective nucleoside transporter (SPNT; concentrative nucleoside transporter 2), for nucleosides, nucleobases, and base- and ribose-modified nucleoside analogs. The two-electrode voltage-clamp technique in Xenopus laevisoocytes expressing these transporters was used. Purine

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15

Wan, Hongwei, Raja Ben Othman, Laurent Le Corre, et al. "New MraYAA Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole." Antibiotics 11, no. 9 (2022): 1189. http://dx.doi.org/10.3390/antibiotics11091189.

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New inhibitors of the bacterial transferase MraY from Aquifex aeolicus (MraYAA), based on the aminoribosyl uridine central core of known natural MraY inhibitors, have been designed to generate interaction of their oxadiazole linker with the key amino acids (H324 or H325) of the enzyme active site, as observed for the highly potent inhibitors carbacaprazamycin, muraymycin D2 and tunicamycin. A panel of ten compounds was synthetized notably thanks to a robust microwave-activated one-step sequence for the synthesis of the oxadiazole ring that involved the O-acylation of an amidoxime and subsequen

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16

Krylova, Irina B., Albina F. Safonova, and Natalia R. Evdokimova. "Correction of hypoxic state by metabolic precursors of endogenous activator of mitochondrial ATP-dependent K+channels." Reviews on Clinical Pharmacology and Drug Therapy 16, no. 3 (2018): 25–31. http://dx.doi.org/10.17816/rcf16325-31.

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Aim. The antihypoxic properties of uridine and uridine-5'-monophosphate (UMP), which are the metabolic precursors of the natural activator of mitochondrial ATP-dependent K+ channels (mitoKATP channels) uridine diphosphat were investigated on the models of hypoxic hypoxia with hypercapnia (HHH), hemic hypoxia and local circulatory hypoxia. Methods. HHH was created in males and females white mice weighing 28-30 g. The animals were placed one by one in hermetically closed container and the duration of their life was determined. The antihypoxic activity of the substances was compared with th

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17

Abdel-Rahman, Adel A. H., and Takeshi Wada. "Synthesis and Antiviral Evaluation of 5-(1,2,3-Triazol-1-ylmethyl)- uridine Derivatives." Zeitschrift für Naturforschung C 64, no. 3-4 (2009): 163–66. http://dx.doi.org/10.1515/znc-2009-3-402.

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Some 5-(1,2,3-triazol-1-ylmethyl)uridine derivatives were synthesized via the 1,3-dipolar cycloaddition of a 5-azidomethyluridine derivative with substituted acetylenes. The antiviral activities of these compounds against hepatitis A virus (HAV, MBB cell culture-adapted strain) and Herpes simplex virus type-1 (HSV-1) were tested.

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18

Lassota, Piotr, Jarosław T. Kuśmierek, Ryszard Stolarski, and David Shugar. "Pyrimidine Homoribonucleosides: Synthesis, Solution Conformation, and Some Biological Properties." Zeitschrift für Naturforschung C 42, no. 5 (1987): 589–98. http://dx.doi.org/10.1515/znc-1987-0516.

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Conversion of uridine and cytidine to their 5′-O-tosyl derivatives, followed by cyanation with tetraethylammonium cyanide, reduction and deamination, led to isolation of the hitherto un- known homouridine (1-(5′-deoxy-β-D-allofuranosyl)uracil) and homocytidine (1-(5′-deoxy-β-ᴅ-allofuranosyl)cytosine), analogues of uridine and cytidine in which the exocyclic 5′-CH2OH chain is extended by one carbon to CH2CH2OH. Homocytidine was also phosphorylated to its 6′-phosphate and 6′-pyrophosphate analogues. In addition, it was converted, via its 2,2′-anhydro derivative, to arahomocytidine, an analogue o

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19

Wurtman, Richard J. "Involvement of Nutrients in the Pathogenesis or Management of Alzheimer’s Disease." US Neurology 07, no. 02 (2011): 87. http://dx.doi.org/10.17925/usn.2011.07.02.87.

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The number of hippocampal and cortical synapses is diminished in early Alzheimers disease (AD) and this loss, which is well correlated with the onset of cognitive deficits, probably reflects both an acceleration in their breakdown and a slowing in their synthesis, perhaps consequent to the concurrent decrease in dendritic spines. No strategies have been identified for increasing the number of synapses. Synaptogenesis requires adequate amounts of highly specialized synaptic membrane and activation of a process for shaping this membrane, initially into dendritic spines and neurites and then int

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20

Wurtman, Richard J. "Involvement of Nutrients in the Pathogenesis or Management of Alzheimer’s Disease." European Neurological Review 7, no. 1 (2012): 25. http://dx.doi.org/10.17925/enr.2012.07.01.25.

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The number of hippocampal and cortical synapses is diminished in early Alzheimer’s disease (AD) and this loss, which is well correlated with the onset of cognitive deficits, probably reflects both an acceleration in their breakdown and a slowing in their synthesis, perhaps consequent to the concurrent decrease in dendritic spines. No strategies have been identified for increasing the number of synapses. Synaptogenesis requires adequate amounts of highly specialised synaptic membrane and activation of a process for shaping this membrane, initially into dendritic spines and neurites and then int

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21

Tong, Zeen, Vijaya Damaraju, Sylvia Yao, et al. "The Role of Human Nucleoside Transporters In Uptake of 5-Azacitidine, 5-Aza-2′-Deoxycytidine and Gemcitabine." Blood 116, no. 21 (2010): 2884. http://dx.doi.org/10.1182/blood.v116.21.2884.2884.

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Abstract Abstract 2884 5-Azacitidine is a cytidine analog, and is used for the treatment of myelodysplastic syndromes. Cellular uptake of nucleosides and nucleoside analogs are mediated by human concentrative nucleoside transporters (hCNTs) and equilibrative nucleoside transporters (hENTs). The objective of this study was to assess the transportability of 5-azacitidine, 5-aza-2`-deoxycytidine and gemcitabine in Saccharomyces cerevisiae yeast and Xenopus laevis oocytes producing individual recombinant hNTs. The relative abilities of the hNT proteins to interact with 5-azacitidine, 5-aza-2`-deox

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22

LOSSANI, A., A. TORTI, S. GATTI, et al. "Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors." Parasitology 136, no. 6 (2009): 595–602. http://dx.doi.org/10.1017/s0031182009005964.

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SUMMARYEntamoeba histolytica is an intestinal parasite and the causative agent of amoebiasis, which is a significant source of morbidity and mortality in developing countries. Although anti-amoebic drugs such as metronidazole, emetine, chloroquine and nitazoxanide are generally effective, there is always potential for development of drug resistance. In order to find novel targets to control E. histolytica proliferation we cloned, expressed and purified thymidine kinase (Eh-TK) and uridine-cytidine kinase (Eh-UCK) from E. histolytica. Eh-TK phosphorylates thymidine with a Km of 0·27 μm, whereas

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23

Drabikowska, Alicja K., Lidia Lissowska, Marcin Draminski, Anna Zgit-Wroblewska, and David Shugar. "Acyclonucleoside Analogues Consisting of 5-and 5,6-Substituted Uracils and Different Acylic Chains: Inhibitory Properties vs Purified E. coli Uridine Phosphorylase." Zeitschrift für Naturforschung C 42, no. 3 (1987): 288–96. http://dx.doi.org/10.1515/znc-1987-0320.

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Synthetic procedures are described for the preparation of a variety of pyrimidine acyclo- nucleoside analogues, in which the aglycones are 5- and 5,6-substituted uracils, and the ribose moiety is replaced by different acyclic chains. These were examined as potential inhibitors of purified E. coli uridine phosphorylase. None of the compounds was a substrate for uridine phosphorylase, or either a substrate or inhibitor of E. coli thymidine phosphorylase. Kinetic measurements were employed to determine inhibition constants, K1, for inhibition of uridine phosphorylase. One of the more effective of

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24

Lee, C. W. "Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C." Biochemical Journal 300, no. 2 (1994): 407–12. http://dx.doi.org/10.1042/bj3000407.

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The dose-response curves for the inhibition of equilibrative uridine transport by dilazep, dipyridamole and nitrobenzylthioinosine (NBMPR) in undifferentiated HL-60 cells were biphasic. Some 70% of the transport activity was inhibited with IC50 values of 0.7, 1 and 7 nM respectively. No inhibition of the remaining 30% of transport activity was observed until the dilazep, dipyridamole and NBMPR concentrations exceeded 1, 0.1 and 3 microM respectively. Exposure to phorbol 12-myristate 13-acetate (PMA) for 48 h, to induce monocytic differentiation, caused a 20-fold decrease in Vmax. of both NBMPR

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25

Krol, Ewelina, Ilona Wandzik, Gabriela Brzuska, Luděk Eyer, Daniel Růžek, and Boguslaw Szewczyk. "Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus." Molecules 24, no. 6 (2019): 1129. http://dx.doi.org/10.3390/molecules24061129.

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Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system. Although effective vaccines are available on the market, they are recommended only in endemic areas. Despite many attempts, there are still no specific antiviral therapies for TBEV treatment. Previously, we synthesized a series of uridine derivatives of 2-deoxy sugars and proved that some compounds show antiviral activity against viruses from the Flaviviridae and Orthomyxoviridae families targeting the late steps of the N-g

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26

Manfredini, Stefano, Nicola Solaroli, Angela Angusti, et al. "Design and Synthesis of Phosphonoacetic Acid (PPA) Ester and Amide Bioisosters of Ribofuranosylnucleoside Diphosphates as Potential Ribonucleotide Reductase Inhibitors and Evaluation of Their Enzyme Inhibitory, Cytostatic and Antiviral Activity." Antiviral Chemistry and Chemotherapy 14, no. 4 (2003): 183–94. http://dx.doi.org/10.1177/095632020301400403.

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Continuing our investigations on inhibitors of ribonucleotide reductase (RNR), the crucial enzyme that catalyses the reduction of ribonu-cleotides to deoxyribonucleotides, we have now prepared and evaluated 5′-phosphonoacetic acid, amide and ester analogues of adenosine, uridine and cytidine with the aim to verify both substrate specificity and contribution to biological activity of diphosphate mimic moieties. A molecular modelling study has been conducted on the RNR R1 subunit, in order to verify the possible interaction of the proposed bioisosteric moieties. The study compounds were finally

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27

Ruswanto, Ruswanto, Imam Mustaqim Garna, Lilis Tuslinah, Richa Mardianingrum, Tresna Lestari, and Tita Nofianti. "Kuersetin, Penghambat Uridin 5-Monofosfat Sintase Sebagai Kandidat Anti-kanker." ALCHEMY Jurnal Penelitian Kimia 14, no. 2 (2018): 236. http://dx.doi.org/10.20961/alchemy.14.2.14396.236-254.

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<p>Kanker adalah pembentukan jaringan baru yang abnormal dan bersifat ganas. Efek toksisitas yang ditimbulkan pada setiap senyawa obat antikanker selalu menjadi problem dalam pengobatan kanker dengan cara kemoterapi, maka dari itu perlu dicari alternatife lain untuk mengatasi kanker. Kuersetin telah diketahui mempunyai aktivitas sitotoksik pada sel kanker tapi belum diketahui mekanisme kerjanya. Pada penelitian ini telah dilakukan penelitiaan <em>in silico</em> untuk mengetahui target reseptor dari senyawa kuersetin melalui identifikasi target reseptor melalui <a href="htt

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28

Chu, Zhi-Bo, Jun Chang, Ying Zhu, and Xun Sun. "Chemical Constituents of Cordyceps cicadae." Natural Product Communications 10, no. 12 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001233.

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One new bifuran derivative (1), together with fourteen known compounds, were isolated from Cordyceps cicadae X. Q. Shing. The known compounds included nine nucleosides, uracil (2), uridine (3), 2′-deoxyuridine (4), 2′-deoxyinosine (5), guanosine (6), 2′-deoxyguanosine (7), thymidine (8), adenosine (9), and 2′-deoxyadenosine (10); three amino acids tryptophan (11), phenylalanine (12), and tyrosine (13); and two dopamine analogues N-acetylnoradrenaline (14) and its dimer, trans–2-(3′,4′-dihydroxyphenyl)-3-acetylamino-7-( N-acetyl-2″-amino-ethylene)-1,4-benzodioxane (15). Their structures were de

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29

Kuś, Piotr. "Honey as Source of Nitrogen Compounds: Aromatic Amino Acids, Free Nucleosides and Their Derivatives." Molecules 25, no. 4 (2020): 847. http://dx.doi.org/10.3390/molecules25040847.

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The content of selected major nitrogen compounds including nucleosides and their derivatives was evaluated in 75 samples of seven varieties of honey (heather, buckwheat, black locust, goldenrod, canola, fir, linden) by targeted ultra-high performance liquid chromatography-diode array detector - high-resolution quadrupole time-of-flight mass spectrometry (UHPLC-DAD-QqTOF-MS) and determined by UHPLC-DAD. The honey samples contained nucleosides, nucleobases and their derivatives (adenine: 8.9 to 18.4 mg/kg, xanthine: 1.2 to 3.3 mg/kg, uridine: 17.5 to 51.2 mg/kg, guanosine: 2.0 to 4.1 mg/kg; mean

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30

Bhattacharya, Asish K., Florian Stolz, Jürgen Kurzeck, Wolfgang Rüger, and Richard R. Schmidt. "Synthesis and in vitro evaluation of substituted aryl- and hetarylmethyl phosphonate and phosphate UMP derivatives as potential glucosyltransferase inhibitors." Canadian Journal of Chemistry 80, no. 8 (2002): 973–82. http://dx.doi.org/10.1139/v02-119.

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The enzyme β (1[Formula: see text]4)-glucosyltransferase (BGT) catalyses the transfer of glucose from uridine diphosphoglucose (UDP-Glc) to 5-hydroxymethylcytosine (5-HMC) bases in double-stranded DNA. Potential inhibitors of BGT were developed by structure-based design and synthesized. The designed inhibitors 16 provide conformational mimicry of the transition state in glucosyltransfer reactions. The key synthetic steps involve a MichaelisArbuzov reaction followed by coupling with uridine-5'-morpholidophosphate as activated UMP derivative. The compounds were tested for in vitro inhibitory a

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31

Naydenova, Zlatina G., Konstantin C. Grancharov, Dimitar K. Alargov, et al. "Inhibition of UDP-glucuronosyltransferase by 5'-O-amino Acid and Oligopeptide Derivatives of Uridine: Structure-Activity Relationships." Zeitschrift für Naturforschung C 53, no. 3-4 (1998): 173–81. http://dx.doi.org/10.1515/znc-1998-3-406.

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Abstract The inhibitory effect of a series of 5′-O-amino acid and oligopeptide derivatives of uridine on rat liver UDP-glucuronosyltransferase (UGT) activities was investigated using two assay systems. A quantitative structure-activity relationship (QSAR) study was performed. The compounds include a lipophilic residue linked to the nucleoside by a variable spacer. More over, half of the derivatives have two spacers linked to the uridine moiety. Compound 1, a serine derivative of isopropylideneuridine, was found to be the most potent inhibitor of both 4-nitrophenol (4-NP) and phenolphthalein (

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BALZARINI, Jan, Chaoyong ZHU, Erik DE CLERCQ, et al. "Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2." Biochemical Journal 351, no. 1 (2000): 167–71. http://dx.doi.org/10.1042/bj3510167.

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The ribonucleoside analogues (E)-5-(2-bromovinyl)uridine (5-BV-Urd) and 3´-spiro-(4´-amino-1´,2´-oxathiole-2´,2´-dioxide)-5-methyluridine (3´-AOD-5-MeUrd) emerged as potent and selective competitive inhibitors of mitochondrial thymidine kinase (TK)-2 with respect to thymidine (Ki/Km values of 9.0 and 1.2 respectively). Cytosolic TK-1 did not show measurable affinity for these compounds. [32P]Phosphate transfer studies from [γ-32P]ATP to 5-BV-Urd and 3´-AOD-5-MeUrd revealed extremely poor substrate activity but potent inhibitory potential of the compounds. It was concluded that the ribonucleosi

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Rondla, Ramu, Steven J. Coats, Tamara R. McBrayer та ін. "Anti-hepatitis C Virus Activity of Novel β-D-2′-C-methyl-4′-azido Pyrimidine Nucleoside Phosphoramidate Prodrugs". Antiviral Chemistry and Chemotherapy 20, № 2 (2009): 99–106. http://dx.doi.org/10.3851/imp1400.

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Background: 2′- C-methyl and 4′-azido nucleosides have previously demonstrated inhibition of hepatitis C virus (HCV) replication by targeting the RNA-dependent RNA polymerase NS5B. In an effort to discover new and more potent anti-HCV agents, we envisioned synthesizing nucleoside analogues by combining the 2′- C-methylmoiety with the 4′-azido-moiety into one molecule. Methods: 2′- C-methyl-4′-azido pyrimidine nucleosides were synthesized by first converting 2′- C-methyl ribonucleosides to the corresponding 4′-exocyclic methylene nucleosides. Treatment with iodine azide, benzoylation of the 2′-

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Kniess, Torsten, Michaela Grote, Bernhard Noll, and Bernd Johannsen. "Synthesis and Enzymatic Evaluation of Nucleosides Derived from 5-Iodo-2’-Halo-2’-Deoxyuridines." Zeitschrift für Naturforschung B 58, no. 2-3 (2003): 226–30. http://dx.doi.org/10.1515/znb-2003-2-304.

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The synthesis of new nucleosides by alkenylation of 5-iodo-2’-halo-2’-deoxyuridines with E-(1-tributylstannyl)-propene-1-ol via STILLE-coupling is described. The new compounds are characterized by 1H NMR and elemental analysis. All nucleosides are evaluated by an enzymatic assay to be substrates of herpes simplex virus type 1 thymidine kinase (HSV-1 TK) and compared with uridine, thymidine and (E)-5-(2-iodovinyl)-2’-fluoro-2’-deoxyuridine (IVFRU).

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Arnold, Luboš, Jiří Smrt, Jaroslav Zajíček, Günther Ott, Michael Schiesswohl, and Mathias Sprinzl. "Dimethylaminomethylene protected purine H-phosphonates in the synthesis of biologically active RNA (24-mer)." Collection of Czechoslovak Chemical Communications 56, no. 9 (1991): 1948–56. http://dx.doi.org/10.1135/cccc19911948.

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Preparation of 5’-O-(4,4’-dimethoxytrityl)-2’-O-tert-butyldimethylsilyl (tBDMSi) derivatives of N2-dimethylaminomethyleneguanosine (IIIa) and N6-dimethylaminomethyleneadenosine (IVa) and their 3’-H-phosphonates (IIIb, IVb) is described. The compounds IIIb and IVb together with corresponding derivatives of uridine (Vb) and N4-benzoylcytidine (VIb) were used as synthones in machine assisted synthesis of microhelixAla (5’-GGGGCUAUAGCUCUAGCU.CCACCA-3’) (X). The compound X was aminoacylated by means of alanyl-t-RNA synthetase (E.coli).

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Brabec, Viktor, and Katsumi Niki. "Raman scattering from adenine, uracil and their derivatives adsorbed at a silver electrode." Collection of Czechoslovak Chemical Communications 51, no. 1 (1986): 167–74. http://dx.doi.org/10.1135/cccc19860167.

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Adsorption at a silver electrode of adenine, uracil and their monomeric nucleosides and nucleotides from neutral solutions of KCl was studied by means of Raman spectroscopy and the measurement of the double-layer capacitance. It was found that all compounds investigated except uridine 5'-monophosphate were strongly adsorbed at a positively charged electrode. Analysis of the surface Raman spectra was performed with the aim of obtaining qualitative information on the orientation and configuration of nucleic acid components in the adsorbed state. The results of this analysis were compatible with

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Komor, Roman, Gabriela Pastuch-Gawolek, Ewelina Krol, and Wieslaw Szeja. "Synthesis and Preliminary Evaluation of Biological Activity of Glycoconjugates Analogues of Acyclic Uridine Derivatives." Molecules 23, no. 8 (2018): 2017. http://dx.doi.org/10.3390/molecules23082017.

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Herein we present the methodology for obtaining glycosyltransferase inhibitors, analogues of natural enzyme substrates of donor-type: UDP-glucose and UDP-galactose. The synthesis concerned glycoconjugates, nucleoside analogues containing an acyclic ribose mimetic linked to a uracil moiety in their structure. The biological activity of the synthesised compounds was determined on the basis of their ability to inhibit the model enzyme action of β-1,4-galactosyltransferase from bovine milk. The obtained results allowed to expand and supplement the existing library of synthetic compounds that are a

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Nguyen Thien, Truong Van, Thien Tai Phan, Tung Thanh Phan, et al. "Chemical constituents of the ethyl acetate extract from the leaf of mugwort (Artemisia vulgaris L.)." Science and Technology Development Journal 22, no. 4 (2019): 352–255. http://dx.doi.org/10.32508/stdj.v22i4.1744.

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Introduction: Mugwort (Artemisia vulgaris L.) is a familiar herbal medicine and also a daily vegetable. It is one of the ingredients in the famous remedy "Cao ích mẫu" specializing in menstrual disorders or the omelet with mugwort that helps save blood flow to the brain to treat headaches. In both traditional medicine and the new drugs, diseases are usually treated by mugwort as diabetes, epilepsy combination for psychoneurosis, depression, irritability, insomnia, anxiety, and stress. To demonstrate the medicinal uses, the chemical constituents of this herbal were continually studied. Me

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Stuthridge, T. R., S. M. Anderson, J. S. Gifford, M. J. Robinson, and D. L. Straus. "Bioaccumulation of dehydroabietic acid in rainbow trout (Oncorhynchus mykiss): role of biotransformation enzymes." Water Science and Technology 35, no. 2-3 (1997): 365–72. http://dx.doi.org/10.2166/wst.1997.0559.

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The role of Phase I and Phase II metabolism in rainbow trout on the bioaccumulation of dehydroabietic acid, an abundant and persistent compound found in pulp and paper mill effluents, was investigated using known inducer/inhibitor compounds for cytochromes P450 (P450s), ethoxyresorufin O-deethylase (EROD) and uridine diphosphoglucuronosyltransferase (UDPGT). The inducer/inhibitor compounds consisted of piperonyl butoxide (PBO), salicylamide (SAL) and β-naphthoflavone (βNF). PBO induced EROD, SAL had no effect on the measured biotransformation enzyme activities and βNF induced EROD and UDPGT. T

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Pels Rijcken, W. R., B. Overdijk, D. H. Van den Eijnden, and W. Ferwerda. "The effect of increasing nucleotide-sugar concentrations on the incorporation of sugars into glycoconjugates in rat hepatocytes." Biochemical Journal 305, no. 3 (1995): 865–70. http://dx.doi.org/10.1042/bj3050865.

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Treatment of rat hepatocytes with 0.5 mM concentrations of uridine and cytidine results in increased cellular concentrations of UTP, UDP-sugars and CTP, whereas that of CMP-N-acetylneuraminate remained unchanged [Pels Rijcken, Overdijk, Van den Eijnden and Ferwerda (1993) Biochem. J. 293, 207-213]. The incorporation of radioactivity from 3H-labelled sugars into the cell-associated and secreted glycoconjugate fraction was influenced by these altered cellular concentrations of the nucleotides. For [3H]glucosamine, pretreatment with uridine resulted in a reduction of the glycosylation in both fra

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Krol, Ewelina, Gabriela Pastuch-Gawolek, Binay Chaubey, Gabriela Brzuska, Karol Erfurt, and Boguslaw Szewczyk. "Novel Uridine Glycoconjugates, Derivatives of 4-Aminophenyl 1-Thioglycosides, as Potential Antiviral Compounds." Molecules 23, no. 6 (2018): 1435. http://dx.doi.org/10.3390/molecules23061435.

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ISHIKAWA, Ichiro, Tsuneo ITOH, Hiroaki TAKAYANAGI, et al. "The Photocycloaddition Reactions of Uridine and Related Compounds with 2,3-Dimethyl-2-butene." CHEMICAL & PHARMACEUTICAL BULLETIN 39, no. 8 (1991): 1922–30. http://dx.doi.org/10.1248/cpb.39.1922.

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Li, Guiying, Yulong Zhang, Hongwei Sun, et al. "Photocatalytic and photoelectrocatalytic degradation of small biological compounds: A case study of uridine." Catalysis Today 201 (March 2013): 167–74. http://dx.doi.org/10.1016/j.cattod.2012.03.024.

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Li, Siqiang, Fujia Chen, Yun Li, et al. "Rhamnose-Containing Compounds: Biosynthesis and Applications." Molecules 27, no. 16 (2022): 5315. http://dx.doi.org/10.3390/molecules27165315.

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Rhamnose-associated molecules are attracting attention because they are present in bacteria but not mammals, making them potentially useful as antibacterial agents. Additionally, they are also valuable for tumor immunotherapy. Thus, studies on the functions and biosynthetic pathways of rhamnose-containing compounds are in progress. In this paper, studies on the biosynthetic pathways of three rhamnose donors, i.e., deoxythymidinediphosphate-L-rhamnose (dTDP-Rha), uridine diphosphate-rhamnose (UDP-Rha), and guanosine diphosphate rhamnose (GDP-Rha), are firstly reviewed, together with the functio

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Zakharenko, Alexandra L., Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, et al. "Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides." Molecules 25, no. 16 (2020): 3694. http://dx.doi.org/10.3390/molecules25163694.

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Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. New effective Tdp1 inhibitors were found in a series of nucleoside derivatives possessing 2′,3′,5′-tri-O-benzoyl-d-ribofuranose and 5-substituted uracil moieties and have half-maximal inhibitory concentrations (IC50) in the lower micromolar and submicromolar range. 2′,3′,5′-Tri-O-benzoyl-5-iodouridine manifested the strongest inhibitory effect on Tdp1 (IC50 = 0.6 μM). A decrease in the number of benzoic acid residues led

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Ivanova, Antoaneta, Bozhanka Mikhova, Hristo Najdenski, Iva Tsvetkova, and Ivanka Kostova. "Chemical Composition and Antimicrobial Activity of Wild Garlic Allium ursinum of Bulgarian Origin." Natural Product Communications 4, no. 8 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400808.

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The chemical composition of fresh flowers from Allium ursinum (ramsons, bear's garlic, wild garlic) growing in Bulgaria has been studied. Thymidine (1), adenosine (2), astragalin (kaempferol-3-O-β-D-glucopyranoside (3), kaempferol-3-O-D-glucopyranosyl-7-O-D-glucopyranoside (4), kaempferol-3-O-D-neohesperoside (5), and kaempferol-3-O-D-neohesperoside-7-O-D-glucopyranoside (6) were isolated from the n-butanol extract and identified by different spectroscopic and spectrometric methods. Thymine (7), uridine (8), uracil (9) and 5-chloro-uridine (10) were detected in the same extract by GC-MS. This

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Brzuska, Gabriela, Gabriela Pastuch-Gawolek, Monika Krawczyk, Boguslaw Szewczyk, and Ewelina Krol. "Anti-Tick-Borne Encephalitis Virus Activity of Novel Uridine Glycoconjugates Containing Amide or/and 1,2,3-Triazole Moiety in the Linker Structure." Pharmaceuticals 13, no. 12 (2020): 460. http://dx.doi.org/10.3390/ph13120460.

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Tick-borne encephalitis virus (TBEV) transmitted by ticks is a pathogen of great medical importance. As still no effective antiviral treatment is available, in the present study, a series of uridine glycoconjugates containing amide or/and 1,2,3-triazole moiety in the linker structure was synthesized and evaluated for the antiviral activity against two strains of TBEV: a highly virulent Hypr strain and less virulent Neudoerfl strain, using standardized previously in vitro assays. Our data have shown that four compounds from the series (18–21) possess strong activity against both TBEV strains. T

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Rodríguez Lara, Avilene, María Dolores Mesa-García, Karla Alejandra Damián Medina, et al. "Assessment of the Phytochemical and Nutrimental Composition of Dark Chia Seed (Salvia hispánica L.)." Foods 10, no. 12 (2021): 3001. http://dx.doi.org/10.3390/foods10123001.

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Chia seeds are rich sources of different macro and micronutrients associated with health benefits; thus, they may be considered as a functional food. However, the composition depends on the variety, origin, climate and soil. Here, we show a comprehensive characterization of extractable and non-extractable phenolic compounds of dark chia seed Salvia hispanica L. using high-performance liquid chromatography–electrospray ionization–quadrupole time-of-flight (HPLC-ESI-QTOF) and discuss potential health benefits associated with the presence of a number of nutritional and bioactive compounds. We rep

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Oliver, Martin, Laurent Le Corre, Mélanie Poinsot, et al. "A Sub-Micromolar MraYAA Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling." Molecules 27, no. 6 (2022): 1769. http://dx.doi.org/10.3390/molecules27061769.

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New inhibitors of the bacterial tranferase MraY are described. Their structure is based on an aminoribosyl uridine scaffold, which is known to be important for the biological activity of natural MraY inhibitors. A decyl alkyl chain was introduced onto this scaffold through various linkers. The synthesized compounds were tested against the MraYAA transferase activity, and the most active compound with an original (S,S)-tartaric diamide linker inhibits MraY activity with an IC50 equal to 0.37 µM. Their antibacterial activity was also evaluated on a panel of Gram-positive and Gram-negative strain

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Chuluunbaatar, Bayar, Zoltán Béni, Miklós Dékány, et al. "Triterpenes from the Mushroom Hypholoma lateritium: Isolation, Structure Determination and Investigation in Bdelloid Rotifer Assays." Molecules 24, no. 2 (2019): 301. http://dx.doi.org/10.3390/molecules24020301.

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Twelve compounds (1–12) were isolated from the methanol extract of brick cap mushroom (Hypholoma lateritium (Schaeff.) P. Kumm.). The structures of the compounds were elucidated using extensive spectroscopic analyses, including NMR and MS measurements. Lanosta-7,9(11)-diene-12β,21α-epoxy-2α,3β,24β,25-tetraol (1) and 8-hydroxy-13-oxo-9E,11E-octa-decadienoic acid (2) were identified as new natural products, together with ten known compounds, from which 3β-hydroxyergosta-7,22-diene (4), demethylincisterol A2 (5), cerevisterol (6), 3β-O-glucopyranosyl-5,8-epidioxyergosta-6,22-diene (7), fasciculol

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