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Journal articles on the topic 'Urinary detrusor'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Musci, R., V. Franchini, T. Meroni, et al. "Neurogenic urinary dysfunction in AIDS patients." Urologia Journal 61, no. 2 (1994): 137–41. http://dx.doi.org/10.1177/039156039406100209.

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From May 1992 to December 1993 (17 months), 18 patients with AIDS, 15 male and 3 female, age range from 25 to 50, were found to have severe voiding disorders related to neurogenic bladder dysfunction. All patients underwent neurologic, urologic and immunologic evaluation and were staged as AIDS-IVB. The neurological evaluation demonstrated: cryptococcal abscess of the brain in 1 patient, progressive and diffuse leukoencephalopathy in 3 patients, AIDS Dementia Complex in 3 patients and no neurologic abnormalities in 11 patients. The urodynamic tests demonstrated: detrusor areflexia in 5 patient

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2

Sakakibara, Ryuji, Ayami Shimizu, Osamu Takahashi, et al. "Lower Urinary Tract Function in Familial Spastic Paraplegia." European Neurology 80, no. 3-4 (2018): 121–25. http://dx.doi.org/10.1159/000494030.

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In order to investigate lower urinary tract function in hereditary spastic paraplegia (HSP), we recruited 12 HSP patients: 8 men, 4 women; mean age, 64.6 years; mean disease duration, 18.9 years; walk without cane, 2, walk with cane, 6, wheelchair bound, 3. We performed urinary symptom questionnaires and a urodynamic testing in all patients. As a result, urinary symptoms were observed in all but 3, including urinary urgency/frequency (also called overactive bladder) in 9 and hesitancy/poor stream in 6. Urodynamic abnormalities included detrusor overactivity during bladder filling in 10, undera

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3

Andersson, Karl-Erik, and Anders Arner. "Urinary Bladder Contraction and Relaxation: Physiology and Pathophysiology." Physiological Reviews 84, no. 3 (2004): 935–86. http://dx.doi.org/10.1152/physrev.00038.2003.

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The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its ability to contract over a large length interval and to relax determines the bladder function during filling and micturition. These processes are regulated by several external nervous and hormonal control systems, and the detrusor contains multiple receptors and signaling pathways. Functional changes of the detrusor can be found in several clinically important conditions, e.g., lower urinary tract symptoms (LUTS) and bladder outlet obstruction. The aim of this review is to summarize and synthesize basic in

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Gorbunov, Aleksandr I., Aleksandr N. Murav’ev, Evgenij G. Sokolovich, and Petr K. Yablonsky. "Neurogenic urinary disorders in patients with tuberculous spondylitis before and after surgical treatment." Urology reports (St. - Petersburg) 11, no. 1 (2021): 27–32. http://dx.doi.org/10.17816/uroved52482.

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ABSTRACT: Tuberculosis inflammation of vertebral column (spondylitis) can lead to neurogenic lower urinary tract dysfunction. There is lack of available publications for neurogenic lower urinary tract dysfunction in spinal tuberculosis. OBJECTIVE: To evaluate urodynamic disturbances in spinal tuberculosis before and after surgery for spondylitis. MATERIALS AND METHODS: We observed 19 patients with spinal tuberculosis, who had symptoms of micturitions impairment. 14 patients (73,6%) were male and 5 (26,4%) were female, average age was 43,7 7,9 years (2766). Control evaluation was pe

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Griffiths, D. J., C. E. Constantinou, and R. van Mastrigt. "Urinary bladder function and its control in healthy females." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 251, no. 2 (1986): R225—R230. http://dx.doi.org/10.1152/ajpregu.1986.251.2.r225.

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Recordings in eight healthy female volunteers of bladder (detrusor) pressure and flow rate, obtained during bladder filling and during voiding, both through the urethra and through a catheter, demonstrate that a model of bladder function in which the detrusor muscle is considered as completely passive during filling and fully activated during voiding is inadequate. Assessment of the detrusor contraction strength by a new method (described in APPENDIX A) shows that in ideal normal voidings the contraction strength rises to values of 11-24 W/m2 and is sustained or rises slightly until the bladde

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OKAMOTO-KOIZUMI, Takako, Masayuki TAKEDA, Takeshi KOMEYAMA, et al. "Pharmacological and molecular biological evidence for ETA endothelin receptor subtype mediating mechanical responses in the detrusor smooth muscle of the human urinary bladder." Clinical Science 96, no. 4 (1999): 397–402. http://dx.doi.org/10.1042/cs0960397.

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The aim of this study was to characterize endothelin receptor subtypes of the detrusor muscle of the human urinary bladder. The receptor subtypes mediating endothelin (ET)-1-induced activity in the human detrusor smooth muscles have been characterized using isometric contraction and reverse transcription–polymerase chain reaction (RT–PCR). ET-1 (a non-selective ET receptor agonist; 10-10 M to 10-6 M) exhibited concentration-dependent contractions in human urinary bladder with a plateau at concentrations above 3×10-7 M. Neither IRL1620 nor sarafotoxin S6c (both ETB-selective agonists; 10-10 M t

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Heppner, Thomas J., Jeffrey J. Layne, Jessica M. Pearson, Hagop Sarkissian, and Mark T. Nelson. "Unique properties of muscularis mucosae smooth muscle in guinea pig urinary bladder." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 301, no. 2 (2011): R351—R362. http://dx.doi.org/10.1152/ajpregu.00656.2010.

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The muscularis mucosae, a type of smooth muscle located between the urothelium and the urinary bladder detrusor, has been described, although its properties and role in bladder function have not been characterized. Here, using mucosal tissue strips isolated from guinea pig urinary bladders, we identified spontaneous phasic contractions (SPCs) that appear to originate in the muscularis mucosae. This smooth muscle layer exhibited Ca2+ waves and flashes, but localized Ca2+ events (Ca2+ sparks, purinergic receptor-mediated transients) were not detected. Ca2+ flashes, often in bursts, occurred with

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Al-Shukri, S. Kh, T. G. Giorgobiani, R. E. Amdiy, and A. S. Al-Shukri. "Urinary dysfunction in patients with unsatisfactory results of surgical treatment of benign prostatic hyperplasia." Grekov's Bulletin of Surgery 176, no. 6 (2017): 66–70. http://dx.doi.org/10.24884/0042-4625-2017-176-6-66-70.

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OBJECTIVE. The study aimed to develop diagnostics and treatment of urinary dysfunction in patients with unsatisfactory results of surgery of benign prostatic hyperplasia (BPH). MATERIAL AND METHODS. The urodynamic studies were made for 93 (72,7 %) patients after transurethral resection of the prostate and 35 (27,3 %) patients after open adenomectomy. All the patients had urinary dysfunctions after surgery of BPH. RESULTS. Detrusor hyperactivity was revealed in 51 (39,9 %) patients. Detrusor hypoactivity was noted in 21 (16,4 %) patients. Combination of detrusor hyperactivity during storage pha

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Noronha, R., H. Akbarali, A. Malykhina, R. D. Foreman, and Beverley Greenwood-Van Meerveld. "Changes in urinary bladder smooth muscle function in response to colonic inflammation." American Journal of Physiology-Renal Physiology 293, no. 5 (2007): F1461—F1467. http://dx.doi.org/10.1152/ajprenal.00311.2007.

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Visceral organ “cross talk” is suspected to contribute to multiorgan symptomatology found in conditions such as irritable bowel syndrome and interstitial cystitis. The goal of the present study was to investigate the short- and long-term effects of acute colitis on bladder detrusor muscle contractility. We hypothesized that inflammation of the colon leads to changes in bladder function via direct changes in detrusor smooth muscle contractility. In this study, colonic inflammation was induced in male rats via an enema of trinitrobenzenesulfonic acid (TNBS) (50 mg/kg, 0.5 ml, 25% ethanol). Colit

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Rusina, Yelena Ivanovna. "The role of complex preoperative urodynamic testing of continent women when planning surgery for pelvic organ prolapse." Journal of obstetrics and women's diseases 63, no. 1 (2014): 17–25. http://dx.doi.org/10.17816/jowd63117-25.

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Women with significant genitourinary prolapse may be continent in spite of a weak urethral sphincter because of kinking of the poorly supported urethra. After the surgery for prolapse 19-30 % of the patients identify “occult” urinary incontinence due to a weak urethral sphincter. The aim of this study is to evaluate the role of complex urodynamic testing to identify “occult” urinary incontinence, neuromuscular dysfunction of the bladder and urethra for adequate combined therapy. Methods: 257 female patients with no urinary incontinence at the age of 30-86 years old were examined, before the su

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Radziszewski, P., R. Crayton, J. Zaborski, et al. "Multiple sclerosis produces significant changes in urinary bladder innervation which are partially reflected in the lower urinary tract functional status-sensory nerve fibers role in detrusor overactivity." Multiple Sclerosis Journal 15, no. 7 (2009): 860–68. http://dx.doi.org/10.1177/1352458509106210.

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Background Detrusor overactivity is often observed in patients with multiple sclerosis (MS), and neurotoxins are emerging as second-line therapies albeit with different degrees of success per patient basis. Objective To investigate lower urinary tract (LUT) functional status and bladder innervation (calcitonin gene related peptide [CGRP] and substance P [SP] positive nerve fibers) in patients with MS. Method Eighteen MS patients with LUT symptoms underwent urodynamic investigations, and six non-MS patients undergoing cystoscopy due to microscopic hematuria served as controls. Cold cut bladder

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Ingargiola, G. B., M. Lamartina, and A. Di Girolamo. "Urodynamics in urinary incontinence." Urologia Journal 65, no. 1 (1998): 28–32. http://dx.doi.org/10.1177/039156039806500104.

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This study outlines the main urethral-bladder disorders responsible, on a neurological basis, for incontinence. It also defines the forms of detrusorial and urethral origin, due to hyper- or hypoactivity of the detrusor and urethra respectively. Brief reference is made to clinical aspects.

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Gad, Parag N., Nelly Kokikian, Kari L. Christe, V. Reggie Edgerton, and Leif A. Havton. "Noninvasive neurophysiological mapping of the lower urinary tract in adult and aging rhesus macaques." Journal of Neurophysiology 119, no. 4 (2018): 1521–27. http://dx.doi.org/10.1152/jn.00840.2017.

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The lower urinary tract (LUT) may be activated by spinal cord stimulation, but the physiological mapping characteristics of LUT activation with noninvasive transcutaneous spinal cord stimulation (TSCS) are not known. The effects of aging on the contractile properties of the detrusor are also not well understood. Therefore, TSCS was applied over the T10/T11 to L6/L7 spinous processes in adult ( n = 6) and aged ( n = 9) female rhesus macaques. A combination of urodynamic studies and electromyography recordings of the external urethral sphincter (EUS), external anal sphincter (EAS), and pelvic fl

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Ballaro, Andrew. "The Elusive Electromyogram in the Overactive Bladder: A Spark of Understanding." Annals of The Royal College of Surgeons of England 90, no. 5 (2008): 362–67. http://dx.doi.org/10.1308/003588408x301217.

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It has been said that a technique capable of recording a urinary bladder electromyogram could be useful in the clinical evaluation of the detrusor neuropathies and myopathies implicated in the generation of lower urinary tract symptoms. However, in contrast to electromyography of skeletal and cardiac muscle, detrusor smooth muscle electromyography has remained in its infancy despite 50 years of scientific effort. The principal problems appear to be isolation of the real signal from artefacts, and the doubtful existence of electromyographic activity during cholinergic muscle contraction. The di

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Smolnova, Tatyana Yu, and D. M. Lukyanova. "The role of genetic polymorphisms and growth factors in pathogenesis of urgent and mixed urinary incontinence in women." Medical Journal of the Russian Federation 22, no. 6 (2016): 325–28. http://dx.doi.org/10.18821/0869-2106-2016-22-5-325-328.

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The purpose of study. To analyze genetic polymorphisms of receptors of bladder, structural components of intercellular matrix of urinary excretion organs, molecular biochemical mechanisms of regulation of function of bladder and urethra resulting in urinary incontinency. Materials and methods. The analysis of publication data concerning genetic polymorphisms and molecular biochemical mechanisms of development of urinary incontinence in women. The results. The publication data is presented concerning impact of genetic polymorphisms of receptors of detrusor on development of urgent and mixed uri

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Islianti, Putri Iradita, Harrina Erlianti Rahardjo, Nur Rasyid, and Arry Rodjani. "PREVALENCE OF LOWER URINARY TRACT SYMPTOMS POST KIDNEY TRANSPLANTATION AND ITS URODYNAMIC PROFILE." Indonesian Journal of Urology 28, no. 2 (2021): 158–63. http://dx.doi.org/10.32421/juri.v28i2.683.

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Objective: This study aimed to describe the urodynamic characteristics of post-transplant kidney patients with LUTS who were indicated for urodynamics. Material & Methods: This research is a cross-sectional study conducted at Cipto Mangunkusumo General Hospital between 2011-2017. Data were collected from patients who had undergone urodynamic examination after kidney transplantation due to LUTS/urinary retention. Data were collected from the patient’s medical record. Results: A total of 536 patients underwent kidney transplants at Cipto Mangunkusumo General Hospital from 2011-2017. Eleven p

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CALVERT, Robert C., Faiz H. MUMTAZ, Mick R. DASHWOOD, et al. "Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl." Clinical Science 103, s2002 (2002): 459S—463S. http://dx.doi.org/10.1042/cs103s459s.

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Endothelin-1 (ET-1) causes urinary bladder smooth muscle contraction and the endothelin receptors A and B (ETA and ETB) are both known to be present in the rabbit urinary bladder. Alterations in ET-1 signalling have been implicated in the pathophysiology of urinary tract disorders secondary to bladder outlet obstruction and also in diabetic cystopathy. Naftidrofuryl (Naf) (marketed under the trade name Praxilene) improves walking distance in patients with peripheral vascular disease, an effect which may be partially attributed to ET-1 antagonism. The purpose of this study is to assess whether

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Klinger, Mary Beth, Abbey Dattilio, and Margaret A. Vizzard. "Expression of cyclooxygenase-2 in urinary bladder in rats with cyclophosphamide-induced cystitis." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293, no. 2 (2007): R677—R685. http://dx.doi.org/10.1152/ajpregu.00305.2007.

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These studies examined the expression of cyclooxygenase-2 (COX-2) expression in the urothelium and suburothelial space and detrusor from rats treated with cyclophosphamide (CYP) to induce acute (4 h), intermediate (48 h), or chronic (10-day) cystitis. Western blot analysis and immunohistochemistry were used to demonstrate COX-2 expression. In whole mount preparations of urinary bladder, nerve fibers in the suburothelial plexus, and inflammatory cell infiltrates were characterized for COX-2 expression after CYP-induced cystitis. COX-2 expression significantly ( P ≤ 0.01) increased in the urothe

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Minaldi, G., B. Ventimiglia, M. Finocchiaro, et al. "Sexual Activity and Urinary Incontinence in Women." Urologia Journal 76, no. 3 (2009): 203–6. http://dx.doi.org/10.1177/039156030907600306.

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Urinary incontinence during sexual intercourse refers to overactive bladder (OAB) syndrome and it is divided in incontinence during penetration and during orgasm. 480 women with low urinary tract symptoms (LUTS) were divided in a) affected by probable genuine stress incontinence, b) probable Urge-stress incontinence, c) probable Urge Incontinence, to specify incidence. Materials and Methods In Group C (186 women) 36 women, age range 24 to 56 years, with urinary incontinence only during sexual intercourse, were selected: 16 during orgasm (group I), 20 during penetration (group II). These patien

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LaBerge, Jennifer, Susan E. Malley, Katarina Zvarova, and Margaret A. Vizzard. "Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 291, no. 3 (2006): R692—R703. http://dx.doi.org/10.1152/ajpregu.00086.2006.

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Corticotropin-releasing factor (CRF) is a prominent neuropeptide involved in micturition reflexes, and different roles in these reflexes have been suggested. These studies examined the expression of CRF in the urinary bladder and lumbosacral sacral parasympathetic nucleus (SPN) in response to cyclophosphamide (CYP)-induced cystitis (4 h, 48 h, or chronic) in rats. The expression of CRF receptors, CRF1 and CRF2, was examined in urinary bladder from control and CYP-treated rats. Urinary bladder and lumbosacral spinal cord were harvested from rats killed by isoflurane (4%) and thoracotomy. CRF pr

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Chung, Doreen E., Benjamin Dillon, Jordan Kurta, Alexandra Maschino, and Jaspreet S. Sandhu. "Detrusor underactivity is prevalent after radical prostatectomy: A urodynamic study including risk factors." Canadian Urological Association Journal 7, no. 1-2 (2013): 33. http://dx.doi.org/10.5489/cuaj.192.

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Introduction: The objective was to determine the prevalence of, and factors that predict, detrusor underactivity (DU) in patients presenting with incontinence or lower urinary tract symptoms (LUTS) following radical prostatectomy (RP). We also determined the prevalence of bladder outlet obstruction (BOO) and detrusor overactivity (DO) in this population.Methods: Patients who underwent urodynamics post-RP were identified. Detrusor underactivity was defined as a maximum flow rate (Qmax) of ≤15 mL/s and detrusor pressure (Pdet) Qmax <20 cmH20 or maximum Pdet <20 cmH20 during attempted voidi

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Dorsher, Peter T., and Peter M. McIntosh. "Neurogenic Bladder." Advances in Urology 2012 (2012): 1–16. http://dx.doi.org/10.1155/2012/816274.

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Congenital anomalies such as meningomyelocele and diseases/damage of the central, peripheral, or autonomic nervous systems may produce neurogenic bladder dysfunction, which untreated can result in progressive renal damage, adverse physical effects including decubiti and urinary tract infections, and psychological and social sequelae related to urinary incontinence. A comprehensive bladder-retraining program that incorporates appropriate education, training, medication, and surgical interventions can mitigate the adverse consequences of neurogenic bladder dysfunction and improve both quantity a

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Gonzalez, Eric J., and Warren M. Grill. "The effects of neuromodulation in a novel obese-prone rat model of detrusor underactivity." American Journal of Physiology-Renal Physiology 313, no. 3 (2017): F815—F825. http://dx.doi.org/10.1152/ajprenal.00242.2017.

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Obesity is a global epidemic associated with an increased risk for lower urinary tract dysfunction. Inefficient voiding and urinary retention may arise in late-stage obesity when the expulsive force of the detrusor smooth muscle cannot overcome outlet resistance. Detrusor underactivity (DUA) and impaired contractility may contribute to the pathogenesis of nonobstructive urinary retention. We used cystometry and electrical stimulation of peripheral nerves (pudendal and pelvic nerves) to characterize and improve bladder function in urethane-anesthetized obese-prone (OP) and obese-resistant (OR)

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Reinfeldt Engberg, Gisela, Clara Ibel Chamorro, Agneta Nordenskjöld, and Magdalena Fossum. "Expansion of Submucosal Bladder Wall TissueIn VitroandIn Vivo." BioMed Research International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/5415012.

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In order to develop autologous tissue engineering of the whole wall in the urinary excretory system, we studied the regenerative capacity of the muscular bladder wall. Smooth muscle cell expansion on minced detrusor musclein vitroandin vivowith or without urothelial tissue was studied. Porcine minced detrusor muscle and urothelium were culturedin vitrounder standard culture conditions for evaluation of the explant technique and in collagen for tissue sectioning and histology. Autografts of minced detrusor muscle with or without minced urothelium were expanded on 3D cylinder moulds by grafting

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Bing, Wu, Shaohua Chang, Joseph A. Hypolite, et al. "Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase." American Journal of Physiology-Renal Physiology 285, no. 5 (2003): F990—F997. http://dx.doi.org/10.1152/ajprenal.00378.2002.

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Detrusor smooth muscle (DSM) undergoes hypertrophy after partial bladder outlet obstruction (PBOO) in male rabbits, as it does in men with PBOO induced by benign prostatic hyperplasia. Despite detrusor hypertrophy, some bladders are severely dysfunctional (decompensated). In this study, the rabbit model for PBOO was used to determine the biochemical regulation of the contractile apparatus and force maintenance by the detrusor from decompensated bladders (DB). Bladders from sham-operated rabbits served as a control. On stimulation with 125 mM KCl, the DSM from sham-operated (SB) rabbits showed

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Kawata, Ryoya, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, and Kazunori Kimura. "Effects of High Salt Intake on Detrusor Muscle Contraction in Dahl Salt-Sensitive Rats." Nutrients 13, no. 2 (2021): 539. http://dx.doi.org/10.3390/nu13020539.

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High salt intake has been reported as a risk factor for urinary storage symptoms. However, the association between high salt intake and detrusor muscle contraction is not clear. Therefore, we investigated the effects of high salt intake on the components of detrusor muscle contraction in rats. Six-week-old male Dahl salt-resistant (DR; n = 5) and Dahl salt-sensitive (DS; n = 5) rats were fed a high salt (8% NaCl) diet for one week. The contractile responses of the detrusor muscle to the cumulative administration of carbachol and electrical field stimulation (EFS) with and without suramin and a

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Gomes, Cristiano M., Sami Arap, and Flávio E. Trigo-Rocha. "Voiding dysfunction and urodynamic abnormalities in elderly patients." Revista do Hospital das Clínicas 59, no. 4 (2004): 206–15. http://dx.doi.org/10.1590/s0041-87812004000400010.

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Lower urinary tract dysfunction is a major cause of morbidity and decreased quality of life in elderly men and women. With the progressive aging of the population, it is important to understand common micturitional disorders that may occur in this population. Most urinary problems in the elderly are multifactorial in origin, demanding a comprehensive assessment of the lower urinary tract organs, functional impairments, and concurrent medical diseases. Urodynamics is a highly valuable tool in the investigation of elderly patients with lower urinary tract symptoms. Urodynamic tests are not alway

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KENI, LAXMIKANT G., SAGAR KALBURGI, B. M. ZEESHAN HAMEED, MOHAMMAD ZUBER, MASAAKI TAMAGAWA, and B. SATISH SHENOY. "FINITE ELEMENT ANALYSIS OF URINARY BLADDER WALL THICKNESS AT DIFFERENT PRESSURE CONDITION." Journal of Mechanics in Medicine and Biology 19, no. 05 (2019): 1950029. http://dx.doi.org/10.1142/s0219519419500295.

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In this work, a 3D urinary bladder was subjected to various pressure loading conditions mimicking the bladder filling volume. The bladder layer consisting of adventitia, detrusor and mucosa layer having different mechanical properties produced different deformation and stresses when subjected to the varying loads. The volume of the bladder changed to 231.34[Formula: see text]ml which was 128.91% higher than the assumed initial volume of 50[Formula: see text]ml on application of 18[Formula: see text]kPa of pressure. The detrusor layer which is thickest of the bladder wall reduced to 1.312[Formu

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Jiang, Yuan-Hong, Sheng-Fu Chen, and Hann-Chorng Kuo. "Frontiers in the Clinical Applications of Botulinum Toxin A as Treatment for Neurogenic Lower Urinary Tract Dysfunction." International Neurourology Journal 24, no. 4 (2020): 301–12. http://dx.doi.org/10.5213/inj.2040354.177.

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Patients with neurogenic lower urinary tract dysfunction (NLUTD) experience urinary incontinence with or without difficult urination, which might promote recurrent urinary tract infection (UTI) and exacerbate upper urinary tract function. Nonetheless, appropriate bladder management has been shown to reduce urological complications and improve quality of life. In addition to pharmacological therapy and surgical intervention, botulinum toxin A (BoNT-A) has been widely utilized in NLUTD. The therapeutic efficacy of detrusor BoNT-A injections for neurogenic detrusor overactivity due to spinal cord

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Ghirca, Veronica Maria, D. Porav-Hodade, C. Chibelean, et al. "The Role of Urodynamic Investigations in Management of Stress Urinary Incontinence." Acta Medica Marisiensis 61, no. 4 (2015): 298–302. http://dx.doi.org/10.1515/amma-2015-0115.

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AbstractObjective: The aim of this study is to establish the importance of urodynamic investigations in women diagnosed with stress urinary incontinence (SUI) who have indication of surgical treatment.Methods: We performed a retrospective study over a period of 3 years (January 2012-December 2014) in Clinic of Urology from Tirgu Mures. The inclusion criteria were: female patients diagnosed with SUI having indication of surgical treatment and the existence of urodynamic investigations (uroflowmetry and pressure-flow study). We evaluated 118 patients with SUI. From this patients, 24 cases (20.3%

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Silva, Fabio Henrique, Celso Saragosa Ramos Filho, Fabiano Beraldi Calmasini, et al. "Oxidative Stress Contributes to Overactive Bladder in the Transgenic Sickle Cell Mouse." Blood 126, no. 23 (2015): 4582. http://dx.doi.org/10.1182/blood.v126.23.4582.4582.

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Abstract Introduction: Lower urinary tract symptoms (LUTS) such as nocturia, urinary frequency, and urgency have been clinically reported in children and adults with sickle cell disease (SCD; Portocarrero et al J Urol 2012; Anele et al Neurourol Urodyn 2015), but little is known about the pathophysiology of micturition dysfunction in SCD patients. Transgenic sickle cell mice have been employed to better understand SCD pathophysiology. Recently, we reported that Berkeley SCD mice display underactive bladder and reduced detrusor smooth muscle contractions (Claudino et al Plos One, 2015). The hom

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Weng, Te I., Hsiao Yi Wu, Pei Ying Lin, and Shing Hwa Liu. "Uropathogenic Escherichia coli-Induced Inflammation Alters Mouse Urinary Bladder Contraction via an Interleukin-6-Activated Inducible Nitric Oxide Synthase-Related Pathway." Infection and Immunity 77, no. 8 (2009): 3312–19. http://dx.doi.org/10.1128/iai.00013-09.

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ABSTRACT Escherichia coli is the most common cause of urinary tract infection. Elevated blood and urine interleukin-6 (IL-6) levels have been shown in inflammatory urinary tract diseases. The role of IL-6 in mediating the urodynamic dysfunction in response to E. coli-induced urinary tract infection has not yet been fully elucidated. In this study, we investigated the role of IL-6 in the nitric oxide (NO)-triggered alteration of contractile responses in the urinary bladder under an E. coli-induced inflammatory condition. The electrical field stimulation (EFS)-evoked contractions of the isolated

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Romine, Mary T., and Gordon F. Anderson. "Evidence for oxytocin receptors in the urinary bladder of the rabbit." Canadian Journal of Physiology and Pharmacology 63, no. 4 (1985): 287–91. http://dx.doi.org/10.1139/y85-052.

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Experiments were performed on isolated detrusor smooth muscle from New Zealand White rabbits. Oxytocin was shown to exhibit high intrinsic contractile activity on isolated strips of detrusor muscle, where the maximum contractile amplitude was 12% greater than control responses to 1 μM carbachol. Repeated applications of 1 μM oxytocin were associated with tachyphylaxis representing a 49% decrease in the amplitude which became reproducible after several applications without further decay of contractile strength. Dose–response experiments indicated that threshold contractions to oxytocin occur at

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Bertapelle, Paola, Giovanni Bodo, and Roberto Carone. "Detrusor Acontractility in Urinary Retention: Detrusor Contractility Test as Exclusion Criteria for Sacral Neurostimulation." Journal of Urology 180, no. 1 (2008): 215–16. http://dx.doi.org/10.1016/j.juro.2008.03.054.

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Hui, C., X. Keji, J. Chonghe, et al. "Combined detrusor-trigone BTX-A injections for urinary incontinence secondary to neurogenic detrusor overactivity." Spinal Cord 54, no. 1 (2015): 46–50. http://dx.doi.org/10.1038/sc.2015.143.

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de Sèze, Marianne, Alain Ruffion, Pierre Denys, Pierre-Alain Joseph, and Brigitte Perrouin-Verbe. "The neurogenic bladder in multiple sclerosis: review of the literature and proposal of management guidelines." Multiple Sclerosis Journal 13, no. 7 (2007): 915–28. http://dx.doi.org/10.1177/1352458506075651.

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Vesicourethral dysfunction is very frequent in multiple sclerosis (MS) and has functional consequences for patients' quality of life and also an organic impact following complications of the neurogenic bladder on the upper urinary tract. While the functional impact and its management are well documented in the literature, the organic impact remains underestimated and there are no consensual practical guidelines for the screening and prevention of MS neurogenic bladder complications. The aim of this review of the literature, focused on identifying the risk factors of urinary tract complications

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Wu, Wei-Yi, Shih-Pin Lee, Bing-Juin Chiang, Wei-Yu Lin, and Chiang-Ting Chien. "Urothelial Calcium-Sensing Receptor Modulates Micturition Function via Mediating Detrusor Activity and Ameliorates Bladder Hyperactivity in Rats." Pharmaceuticals 14, no. 10 (2021): 960. http://dx.doi.org/10.3390/ph14100960.

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The urothelium displays mechano- and chemosensory functions via numerous receptors and channels. The calcium-sensing receptor (CaSR) detects extracellular calcium and modulates several physiological functions. Nonetheless, information about the expression and the role of CaSR in lower urinary tract has been absent. We aimed to determine the existence of urothelial CaSR in urinary bladder and its effect on micturition function. We utilized Western blot to confirm the expression of CaSR in bladder and used immunofluorescence to verify the location of the CaSR in the bladder urothelium via coloca

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Powell, Charles R., Albert Kim, Joshua Roth, et al. "Ossabaw Pig Demonstrates Detrusor Fibrosis and Detrusor Underactivity Associated with Oxidative Stress in Metabolic Syndrome." Comparative Medicine 70, no. 5 (2020): 329–34. http://dx.doi.org/10.30802/aalas-cm-20-000004.

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Metabolic Syndrome (MetS) has detrimental effects on the bladder, including detrusor underactivity. The progression and mechanism of disease are poorly understood. A swine model for diabetic bladder dysfunction (DBD) was established because of the pig's human-sized bladder and its ability to develop MetS by dietary modification alone. The hypothesis of this study is that this swine model will demonstrate oxidative stress associated with MetS, which contributes to both bladder fibrosis and detrusor underactivity (DU). Ossabaw pigs underwent dietary modification consisting of a hypercaloric, ath

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Alam, Md Naushad, Md Fazal Naser, Kamrun Nahar, et al. "Association of Detrusor Muscular Activity With the Outcome of Transurethral Resection of Prostate in Patients With Severity of Bladder Outflow Obstruction." Bangladesh Journal of Urology 18, no. 2 (2020): 56–61. http://dx.doi.org/10.3329/bju.v18i2.49277.

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Objective: To evaluate the association of detrusor muscular activity with outcome of TURP in patients with severity of bladder outflow obstruction. Methods: This is a hospital based cross sectional study conducted in the Department of Urology of Dhaka Medical College Hospital, Dhaka.Elderly male patients having lower urinary tract symptoms (IPSS=20-35) with no retention (non-catheterized patient), who attended in Dhaka Medical College Hospital, were included in the study. A total of 73 patients meeting the enrollment criteria were included in the study. They were evaluated by history, ph

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Puri, Basant K., Mussadiq Shah, Peter O. Julu, Michele C. Kingston, and Jean A. Monro. "Urinary Bladder Detrusor Dysfunction Symptoms in Lyme Disease." International Neurourology Journal 17, no. 3 (2013): 127. http://dx.doi.org/10.5213/inj.2013.17.3.127.

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LANGER, R., R. RON-EL, M. NEWMAN, A. HERMAN, and E. CASPI. "Detrusor instability following colposuspension for urinary stress incontinence." BJOG: An International Journal of Obstetrics and Gynaecology 95, no. 6 (1988): 607–10. http://dx.doi.org/10.1111/j.1471-0528.1988.tb09492.x.

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Lowenstein, Lior, Thythy Pham, Shameem Abbasy, et al. "Observations relating to urinary sensation during detrusor overactivity." Neurourology and Urodynamics 28, no. 6 (2008): 497–500. http://dx.doi.org/10.1002/nau.20680.

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El Yazami Adli, Oussama, and Jacques Corcos. "Botulinum neurotoxin-A treatment of lower urinary tract symptoms in multiple sclerosis." Canadian Urological Association Journal 8, no. 1-2 (2014): 61. http://dx.doi.org/10.5489/cuaj.1824.

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Multiple sclerosis (MS) is the most common neuroinflammatory disease of the central nervous system and a leading cause of disability in young adults. Symptoms related to vesicourethral dysfunction are very prevalent, but not specific to underlying urodynamic abnormalities. Detrusor overactivity and detrusor external sphincter dysynergia are the most frequent findings and are usually linked. Botulinum neurotoxin-A injection represents a significant advance in the management of voiding dysfunction among MS patients failing first-line therapy. It significantly improves patients’ urodynamic parame

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Vahabi, Bahareh, Brian A. Parsons, Olena Doran, Anthony Rhodes, Sarah Dean, and Marcus J. Drake. "TRPM8 agonists modulate contraction of the pig urinary bladder." Canadian Journal of Physiology and Pharmacology 91, no. 7 (2013): 503–9. http://dx.doi.org/10.1139/cjpp-2012-0406.

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The transient receptor potential melastin-8 (TRPM8) channel is activated by the “cooling” compounds menthol and icilin. Pathophysiologically, it is implicated in the overactive bladder and bladder cooling reflex, but the activity of TRPM8 in normal bladder physiology is poorly understood. We investigated the distribution of TRPM8 channels and the effect of TRPM8 agonists on the contractile function of pig bladder (n = 35) strips and whole bladders. The distribution of TRPM8 was examined by immunohistochemistry. The effect of vesical or intravascular menthol (0.1–0.3 mmol/L) or icilin (50 μmol/

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Campos-Sousa, Raimundo Nonato, Elizabeth Maria Aparecida Barasnevicius Quagliato, Kelson James Almeida, Inacio Augusto Dias de Castro, and Viriato Campelo. "Urinary dysfunction with detrusor hyperactivity in women with Parkinson's disease cannot be blamed as a factor of worsening motor performance." Arquivos de Neuro-Psiquiatria 71, no. 9A (2013): 591–95. http://dx.doi.org/10.1590/0004-282x20130101.

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Introduction Detrusor hyperactivity is the leading cause of urinary dysfunction in Parkinson's disease (PD). There are few studies correlating PD clinical aspects with this autonomic feature. Methods A cohort of 63 women with PD were prospectively examined for assessment of clinical aspects and disease severity using unified Parkinson's disease rating scale and Hoehn-Yahr scale, respectively. The urologic function was evaluated by the urodynamic study. Two groups were categorized at this time - groups with and without detrusor hyperactivity. After seven years, the same parameters were re-evalu

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Macnab, Andrew J., Lynn S. Stothers, and Babak Shadgan. "Monitoring Detrusor Oxygenation and Hemodynamics Noninvasively during Dysfunctional Voiding." Advances in Urology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/676303.

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The current literature indicates that lower urinary tract symptoms (LUTSs) related to benign prostatic hyperplasia (BPH) have a heterogeneous pathophysiology. Pressure flow studies (UDSs) remain the gold standard evaluation methodology for such patients. However, as the function of the detrusor muscle depends on its vasculature and perfusion, the underlying causes of LUTS likely include abnormalities of detrusor oxygenation and hemodynamics, and available treatment options include agents thought to act on the detrusor smooth muscle and/or vasculature. Hence, near infrared spectroscopy (NIRS),

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Lin, Yu-Hua, Bing-Juin Chiang, and Chun-Hou Liao. "Mechanism of Action of Botulinum Toxin A in Treatment of Functional Urological Disorders." Toxins 12, no. 2 (2020): 129. http://dx.doi.org/10.3390/toxins12020129.

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Intravesical botulinum toxin (BoNT) injection is effective in reducing urgency and urinary incontinence. It temporarily inhibits the detrusor muscle contraction by blocking the release of acetylcholine (Ach) from the preganglionic and postganglionic nerves in the efferent nerves. BoNT-A also blocks ATP release from purinergic efferent nerves in the detrusor muscle. In afferent nerves, BoNT-A injection markedly reduces the urothelial ATP release and increases nitric oxide (NO) release from the urothelium. BoNT-A injection in the urethra or bladder has been developed in the past few decades as t

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Silva, Isabel, Ana Filipa Costa, Sílvia Moreira та ін. "Inhibition of cholinergic neurotransmission by β3-adrenoceptors depends on adenosine release and A1-receptor activation in human and rat urinary bladders". American Journal of Physiology-Renal Physiology 313, № 2 (2017): F388—F403. http://dx.doi.org/10.1152/ajprenal.00392.2016.

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The direct detrusor relaxant effect of β3-adrenoceptor agonists as a primary mechanism to improve overactive bladder symptoms has been questioned. Among other targets, activation of β3-adrenoceptors downmodulate nerve-evoked acetylcholine (ACh) release, but there is insufficient evidence for the presence of these receptors on bladder cholinergic nerve terminals. Our hypothesis is that adenosine formed from the catabolism of cyclic AMP in the detrusor may act as a retrograde messenger via prejunctional A1 receptors to explain inhibition of cholinergic activity by β3-adrenoceptors. Isoprenaline

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Smith, Phillip P., Anthony DeAngelis, and George A. Kuchel. "Detrusor expulsive strength is preserved, but responsiveness to bladder filling and urinary sensitivity is diminished in the aging mouse." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 302, no. 5 (2012): R577—R586. http://dx.doi.org/10.1152/ajpregu.00508.2011.

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The prevalence of urinary symptoms increases with age and is a significant source of distress, morbidity, and expense in the elderly. Recent evidence suggests that symptoms in the aged may result from sensory dysfunction, rather than abnormalities of detrusor performance. Therefore, we employed a pressure/flow multichannel urethane-anesthetized mouse cystometry model to test the hypothesis that in vivo detrusor performance does not degrade with aging. Secondarily, we sought to evaluate sensory responsiveness to volume using pressure-volume data generated during bladder filling. Cystometric dat

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Southern, Jordan B., Jasmine R. Frazier, Amy S. Miner, John E. Speich, Adam P. Klausner, and Paul H. Ratz. "Elevated steady-state bladder preload activates myosin phosphorylation: detrusor smooth muscle is a preload tension sensor." American Journal of Physiology-Renal Physiology 303, no. 11 (2012): F1517—F1526. http://dx.doi.org/10.1152/ajprenal.00278.2012.

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In rabbit bladder wall (detrusor) muscle, the degree of tone induced during physiological filling (filling tone) is the sum of adjustable preload tension and autonomous contractile tension. The present study was designed to determine whether the level of filling tone is dependent on detrusor muscle length. Maximum active tension induced by KCl was parabolic in relation to length [tension increased from 70% to 100% of a reference length ( Lref) and decreased at longer muscle lengths]. Filling tone, however, increased in a linear fashion from 70% to 120% Lref. In the presence of ibuprofen to abo

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