Academic literature on the topic 'Urinary Kidney Injury Molecule – 1(KIM-1)'

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Journal articles on the topic "Urinary Kidney Injury Molecule – 1(KIM-1)"

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Vinodkumar, R. P., K. Sathiya, R. Kalaiselvi, and K. Suganya. "Urinary Kidney Injury Molecule 1 - A Marker of Kidney Injury in Renal Transplant Patients." International Journal of Pharmaceutical and Clinical Research 16, no. 3 (2024): 118–24. https://doi.org/10.5281/zenodo.10952543.

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<strong>Background:</strong>&nbsp;Chronic kidney disease (CKD) is a public health problem, with rising incidence of kidney failure, with poor outcome. Kidney injury molecule &ndash; 1 (KIM-1) is markedly induced in acute and chronic kidney disease.&nbsp;<strong>Aim:</strong>&nbsp;To determine the role of KIM &ndash; 1 in &nbsp;&nbsp;assessing the severity of renal injury in renal transplant recipients.&nbsp;<strong>Methodology:</strong>&nbsp;A case control study included 45 individuals (group A) of both genders above 18 years with renal transplant recipients and 45 age and sex matched healthy
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van Timmeren, Mirjan M., Stephan J. L. Bakker, Vishal S. Vaidya, et al. "Tubular kidney injury molecule-1 in protein-overload nephropathy." American Journal of Physiology-Renal Physiology 291, no. 2 (2006): F456—F464. http://dx.doi.org/10.1152/ajprenal.00403.2005.

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Kim-1, a recently discovered membrane protein, is undetectable in normal kidneys but markedly induced in proximal tubules after ischemic and toxic injury. The function of Kim-1 is unclear, but it is implicated in damage/repair processes. The Kim-1 ectodomain is cleaved by metalloproteinases and detectable in urine. We studied Kim-1 in a nontoxic, nonischemic, model of tubulointerstitial damage caused by acute proteinuria. Uninephrectomized (NX) rats received daily (ip) injections of 2 g BSA (NX+BSA, n = 12) or saline (NX, n = 6) for 3 wk. Kidneys were stained for various damage markers by immu
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Wajda, Justyna, Paulina Dumnicka, Witold Kolber, et al. "The Marker of Tubular Injury, Kidney Injury Molecule-1 (KIM-1), in Acute Kidney Injury Complicating Acute Pancreatitis: A Preliminary Study." Journal of Clinical Medicine 9, no. 5 (2020): 1463. http://dx.doi.org/10.3390/jcm9051463.

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Acute pancreatitis (AP) may be associated with severe inflammation and hypovolemia leading to organ complications including acute kidney injury (AKI). According to current guidelines, AKI diagnosis is based on dynamic increase in serum creatinine, however, creatinine increase may be influenced by nonrenal factor and appears late following kidney injury. Kidney injury molecule-1 (KIM-1) is a promising marker of renal tubular injury and it has not been studied in AP. Our aim was to assess if urinary KIM-1 may be used to diagnose AKI complicating the early stage of AP. We recruited 69 patients wi
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Al-Tu'ma, Fadhil Jawad, Maha Hamood Dheyauldeen, and Ryiadh Mohi Al-Saegh. "Measurement of urinary kidney injury molecule-1 as a predictive biomarker of contrast-induced acute kidney injury." Journal of Contemporary Medical Sciences 3, no. 9 (2017): 178–81. https://doi.org/10.22317/jcms.v3i9.133.

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Objective The aim of the present study is to evaluate the urinary KIM-1 level in the patients after 24 h angiography as a predictive biomarker of contrast-induced acute kidney injury. Methods This study included 80 selective patients attending in the cardiology unit (48 males, 32 females). The study was conducted in the cardiac catheterization unit at Al- Hussein Medical City/ Kerbala. Clinical examination and laboratory investigations were made before and 24 h after angiography, these investigations include: serum creatinine, blood urea and estimated GFR. Urinary KIM-1 was measured before and
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Vijayasimha, M., and R. K. Jha. "Kidney injury molecule-1 and its diagnostic ability in various clinical conditions." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 583–85. http://dx.doi.org/10.22270/jddt.v9i2-s.2499.

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Objectives: This review evaluates the diagnostic ability of Kidney Injury Molecule 1 (Kim-1) in various clinical conditions. Methods: We screened literature in electronic database from January 2016 to March 2016 by the words “Kidney Injury Molecule-1”or “Kim-1” and “Acute Kidney Injury”. Specific studies were selected for inclusion if they were published in English journals, in which Kim-1 was measured for diagnosis of various forms of Acute Kidney Injury in different articles. Results: There were eight articles which met the selection criteria for inclusion in our study. Compared to non acute
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Ichimura, Takaharu, Cheng Chieh Hung, Soon Ae Yang, James L. Stevens, and Joseph V. Bonventre. "Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury." American Journal of Physiology-Renal Physiology 286, no. 3 (2004): F552—F563. http://dx.doi.org/10.1152/ajprenal.00285.2002.

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Nephrotoxicity is a common side effect of therapeutic interventions, environmental insults, and exposure to toxicants in the workplace. Although biomarkers for nephrotoxicity are available, they often lack sensitivity and are not specific as indicators of epithelial cell injury. Kidney injury molecule-1 (Kim-1) is a type 1 membrane protein with extracellular immunoglobulin and mucin domains. The mRNA and protein for Kim-1 are expressed at very low levels in normal rodent kidney, but expression increases dramatically after injury in proximal tubule epithelial cells in postischemic rodent kidney
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Vaidya, Vishal S., Victoria Ramirez, Takaharu Ichimura, Norma A. Bobadilla, and Joseph V. Bonventre. "Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury." American Journal of Physiology-Renal Physiology 290, no. 2 (2006): F517—F529. http://dx.doi.org/10.1152/ajprenal.00291.2005.

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Sensitive and specific biomarkers are needed to detect early kidney injury. The objective of the present work was to develop a sensitive quantitative urinary test to identify renal injury in the rodent to facilitate early assessment of pathophysiological influences and drug toxicity. Two mouse monoclonal antibodies were made against the purified ectodomain of kidney injury molecule-1 (Kim-1), and these were used to construct a sandwich Kim-1 ELISA. The assay range of this ELISA was 50 pg/ml to 5 ng/ml, with inter- and intra-assay variability of &lt;10%. Urine samples were collected from rats t
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Khreba, Nora A., Mostafa Abdelsalam, A. M. Wahab, et al. "Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients." International Journal of Nephrology 2019 (March 12, 2019): 1–6. http://dx.doi.org/10.1155/2019/6265307.

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Introduction. Postoperative acute kidney injury is associated with a higher mortality, a more complicated hospital course with longer hospital stay. Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery. Methods. We evaluated 45 patients who underwent open heart surgery from January 2016 to June 2016. Both urinary kidney injury molecule 1 and serum creatinine were evaluated before operation and 3hs and 24hs after operation. Acute kidney injury was diagnosed according to Kidney Disease: Improving Globa
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Zeng, Xu, Deloar Hossain, David G. Bostwick, Guillermo A. Herrera та Ping L. Zhang. "Urinary β2-Microglobulin Is a Good Indicator of Proximal Tubule Injury: A Correlative Study with Renal Biopsies". Journal of Biomarkers 2014 (20 листопада 2014): 1–7. http://dx.doi.org/10.1155/2014/492838.

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Objective. After filtration through glomeruli, β2-microglobulin is reabsorbed in proximal tubules. Increased urinary β2-microglobulin indicates proximal tubule injury and measurement of β2-microglobulin in urine is useful to determine the source of renal injury. Kidney injury molecule-1 (KIM-1) has been characterized as a selective proximal tubule injury marker. This study was designed to evaluate the correlation of urinary β2-microglobulin concentration and KIM-1 expression as evidence of proximal tubule injury. Methods. Between 2009 and 2012, 46 patients with urine β2-microglobulin (RenalVys
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Danjuma, Mohammed I., Shaikha Al Shokri, Nadia Bakhsh, Mohammed A. Alamin, Mohamed GH Mohamedali, and Igbiks Tamuno. "The utility of kidney injury molecule-1 as an early biomarker of kidney injury in people living with HIV." International Journal of STD & AIDS 31, no. 13 (2020): 1228–37. http://dx.doi.org/10.1177/0956462420918515.

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There are increasing reports of antiretroviral therapy (ART) drug-related kidney dysfunction. Traditional markers of kidney dysfunction such as urine protein/creatinine ratio and estimated glomerular filtration rate (eGFR) have thus far proven ineffective at detecting some sub-clinical forms of ART-related kidney injury. This is a cross-sectional examination of 114 people living with HIV (PLWH), either naïve ( N =104) or treatment experienced ( N =10). Urinary kidney injury molecule-1 (KIM-1 ng/mg) thresholds were estimated using electrochemiluminescent assays from stored urine samples and nor
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Dissertations / Theses on the topic "Urinary Kidney Injury Molecule – 1(KIM-1)"

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Bukowinski, Andrew. "Novel Urinary Biomarkers of Acute Kidney Injury to Detect Toxicity and Predict Clearance in Pediatric Oncology Patients Treated with High Dose Methotrexate." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427962239.

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Mühlenhardt, Petra. "Funktionelle Untersuchungen zur Bedeutung des Kidney Injury Molecule-1 (Kim-1) bei der Differenzierung der Tubulusepithelzelle von Säugetieren." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-57586.

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Mühlenhardt, Petra [Verfasser]. "Funktionelle Untersuchungen zur Bedeutung des Kidney Injury Molecule-1 (Kim-1) bei der Differenzierung der Tubulusepithelzelle von Säugetieren / Petra Mühlenhardt." München : Universitätsbibliothek München, 2011. http://d-nb.info/1011046423/34.

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Hirt, Marc Nikolaus [Verfasser]. "Untersuchungen zur Signaltransduktion und Funktion von kidney injury molecule-1 (KIM-1) / vorgelegt von Marc Nikolaus Hirt." 2006. http://d-nb.info/981234925/34.

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Mühlenhardt, Petra [Verfasser]. "Funktionelle Untersuchungen zur Bedeutung des kidney injury molecule-1 (Kim-1) bei der Differenzierung der Tubulusepithelzellen von Säugetieren / von Petra Mühlenhardt." 2006. http://d-nb.info/981347304/34.

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John, Anne-Katharina [Verfasser]. "Identifizierung von Kidney injury molecule (KIM 1) als neuer Interaktor von Polycystin 2 und Charakterisierung der Intrazellulärdomäne in Bezug auf die ziliäre Funktion von KIM 1 / vorgelegt von Anne-Katharina John." 2008. http://d-nb.info/994568843/34.

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Book chapters on the topic "Urinary Kidney Injury Molecule – 1(KIM-1)"

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Müller, Andreas, and Martin Meier. "Assessment of Renal Volume with MRI: Experimental Protocol." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_21.

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AbstractRenal length and volume are important parameters in the clinical assessment of patients with diabetes mellitus, kidney transplants, or renal artery stenosis. Kidney size is used in primary diagnostics to differentiate between acute (rather swollen kidneys) and chronic (rather small kidney) pathophysiology. Total kidney volume is also an established biomarker in studies for the treatment of autosomal dominant polycystic kidney disease (ADPKD). There are several factors influencing kidney size, and there is still a debate on the value of the measured kidney size in terms of renal functio
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Echevarría, Lucía, and Aurelie Goyenvalle. "Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_26.

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AbstractAntisense oligonucleotides (ASO) therapeutics hold great promise for the treatment of numerous diseases, and several ASO drugs have now reached market approval, confirming the potential of this approach. However, some candidates have also failed, due to limited biodistribution/uptake and poor safety profile. In pursuit of better delivery and higher cellular uptake, ASO are being optimized, and new chemistries are developed or conjugated with various ligands. While these developments may lead to candidates with higher potency, it is important to keep the safety aspects in sight and scre
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Kumar, Rajesh, Kiran Dahiya, Deepika Dalal, and Neeru Bhaskar. "RECENT URINARY MARKERS IN CHRONIC KIDNEY DISEASE." In Futuristic Trends in Medical Sciences Volume 3 Book 2. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bbms2p3ch2.

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Kidney disease has serious complications whether acute or chronic. CKD cases are in focus due to an unparalleled increase in cases to an unexpected level because of metabolic diseases like diabetes mellitus (DM-II). Other causes of CKD include hypertension (HTN), chronic urinary tract infections, cystic kidney disease and glomerulonephritis. The burden of CKD will rise as the potentiating factors like HTN, DM-2 and obesity are increasing in Asian countries. Recent biomarkers are being tested and used in early and better diagnosis of CKD. These markers are usually present mostly in both serum a
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Conference papers on the topic "Urinary Kidney Injury Molecule – 1(KIM-1)"

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Funke, B., K. E. Jackson, E. D. Siew, et al. "Intravenous Crystalloid Composition Does Not Affect Urinary Kidney Injury Molecule-1 Levels Among Critically Ill Adults." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6707.

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Waikar, S., G. Frendl, A. Mizuguchi, et al. "Urinary KIM-1 for Detection of Acute Kidney Injury after Extrapleural Pneumonectomy." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4483.

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Yoon, Jae-Won, Soo-woong Lee, Md Enamul Haque, et al. "Abstract 1147: A phage display identified peptide selectively binds to kidney injury molecule-1(KIM-1) and detects KIM-1-overexpressing tumorsin vivo." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-1147.

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Yoon, Jae-Won, Soo-woong Lee, Md Enamul Haque, et al. "Abstract 1147: A phage display identified peptide selectively binds to kidney injury molecule-1(KIM-1) and detects KIM-1-overexpressing tumorsin vivo." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-1147.

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