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Journal articles on the topic 'Urinary Kidney Injury Molecule – 1(KIM-1)'

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Published: 5 June 2025

Last updated: 2 August 2025

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1

Vinodkumar, R. P., K. Sathiya, R. Kalaiselvi, and K. Suganya. "Urinary Kidney Injury Molecule 1 - A Marker of Kidney Injury in Renal Transplant Patients." International Journal of Pharmaceutical and Clinical Research 16, no. 3 (2024): 118–24. https://doi.org/10.5281/zenodo.10952543.

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<strong>Background:</strong> Chronic kidney disease (CKD) is a public health problem, with rising incidence of kidney failure, with poor outcome. Kidney injury molecule – 1 (KIM-1) is markedly induced in acute and chronic kidney disease. <strong>Aim:</strong> To determine the role of KIM – 1 in   assessing the severity of renal injury in renal transplant recipients. <strong>Methodology:</strong> A case control study included 45 individuals (group A) of both genders above 18 years with renal transplant recipients and 45 age and sex matched healthy

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van Timmeren, Mirjan M., Stephan J. L. Bakker, Vishal S. Vaidya, et al. "Tubular kidney injury molecule-1 in protein-overload nephropathy." American Journal of Physiology-Renal Physiology 291, no. 2 (2006): F456—F464. http://dx.doi.org/10.1152/ajprenal.00403.2005.

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Kim-1, a recently discovered membrane protein, is undetectable in normal kidneys but markedly induced in proximal tubules after ischemic and toxic injury. The function of Kim-1 is unclear, but it is implicated in damage/repair processes. The Kim-1 ectodomain is cleaved by metalloproteinases and detectable in urine. We studied Kim-1 in a nontoxic, nonischemic, model of tubulointerstitial damage caused by acute proteinuria. Uninephrectomized (NX) rats received daily (ip) injections of 2 g BSA (NX+BSA, n = 12) or saline (NX, n = 6) for 3 wk. Kidneys were stained for various damage markers by immu

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Wajda, Justyna, Paulina Dumnicka, Witold Kolber, et al. "The Marker of Tubular Injury, Kidney Injury Molecule-1 (KIM-1), in Acute Kidney Injury Complicating Acute Pancreatitis: A Preliminary Study." Journal of Clinical Medicine 9, no. 5 (2020): 1463. http://dx.doi.org/10.3390/jcm9051463.

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Acute pancreatitis (AP) may be associated with severe inflammation and hypovolemia leading to organ complications including acute kidney injury (AKI). According to current guidelines, AKI diagnosis is based on dynamic increase in serum creatinine, however, creatinine increase may be influenced by nonrenal factor and appears late following kidney injury. Kidney injury molecule-1 (KIM-1) is a promising marker of renal tubular injury and it has not been studied in AP. Our aim was to assess if urinary KIM-1 may be used to diagnose AKI complicating the early stage of AP. We recruited 69 patients wi

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Al-Tu'ma, Fadhil Jawad, Maha Hamood Dheyauldeen, and Ryiadh Mohi Al-Saegh. "Measurement of urinary kidney injury molecule-1 as a predictive biomarker of contrast-induced acute kidney injury." Journal of Contemporary Medical Sciences 3, no. 9 (2017): 178–81. https://doi.org/10.22317/jcms.v3i9.133.

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Objective The aim of the present study is to evaluate the urinary KIM-1 level in the patients after 24 h angiography as a predictive biomarker of contrast-induced acute kidney injury. Methods This study included 80 selective patients attending in the cardiology unit (48 males, 32 females). The study was conducted in the cardiac catheterization unit at Al- Hussein Medical City/ Kerbala. Clinical examination and laboratory investigations were made before and 24 h after angiography, these investigations include: serum creatinine, blood urea and estimated GFR. Urinary KIM-1 was measured before and

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Vijayasimha, M., and R. K. Jha. "Kidney injury molecule-1 and its diagnostic ability in various clinical conditions." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 583–85. http://dx.doi.org/10.22270/jddt.v9i2-s.2499.

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Objectives: This review evaluates the diagnostic ability of Kidney Injury Molecule 1 (Kim-1) in various clinical conditions. Methods: We screened literature in electronic database from January 2016 to March 2016 by the words “Kidney Injury Molecule-1”or “Kim-1” and “Acute Kidney Injury”. Specific studies were selected for inclusion if they were published in English journals, in which Kim-1 was measured for diagnosis of various forms of Acute Kidney Injury in different articles. Results: There were eight articles which met the selection criteria for inclusion in our study. Compared to non acute

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Ichimura, Takaharu, Cheng Chieh Hung, Soon Ae Yang, James L. Stevens, and Joseph V. Bonventre. "Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury." American Journal of Physiology-Renal Physiology 286, no. 3 (2004): F552—F563. http://dx.doi.org/10.1152/ajprenal.00285.2002.

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Nephrotoxicity is a common side effect of therapeutic interventions, environmental insults, and exposure to toxicants in the workplace. Although biomarkers for nephrotoxicity are available, they often lack sensitivity and are not specific as indicators of epithelial cell injury. Kidney injury molecule-1 (Kim-1) is a type 1 membrane protein with extracellular immunoglobulin and mucin domains. The mRNA and protein for Kim-1 are expressed at very low levels in normal rodent kidney, but expression increases dramatically after injury in proximal tubule epithelial cells in postischemic rodent kidney

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Vaidya, Vishal S., Victoria Ramirez, Takaharu Ichimura, Norma A. Bobadilla, and Joseph V. Bonventre. "Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury." American Journal of Physiology-Renal Physiology 290, no. 2 (2006): F517—F529. http://dx.doi.org/10.1152/ajprenal.00291.2005.

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Sensitive and specific biomarkers are needed to detect early kidney injury. The objective of the present work was to develop a sensitive quantitative urinary test to identify renal injury in the rodent to facilitate early assessment of pathophysiological influences and drug toxicity. Two mouse monoclonal antibodies were made against the purified ectodomain of kidney injury molecule-1 (Kim-1), and these were used to construct a sandwich Kim-1 ELISA. The assay range of this ELISA was 50 pg/ml to 5 ng/ml, with inter- and intra-assay variability of <10%. Urine samples were collected from rats t

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Khreba, Nora A., Mostafa Abdelsalam, A. M. Wahab, et al. "Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients." International Journal of Nephrology 2019 (March 12, 2019): 1–6. http://dx.doi.org/10.1155/2019/6265307.

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Introduction. Postoperative acute kidney injury is associated with a higher mortality, a more complicated hospital course with longer hospital stay. Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery. Methods. We evaluated 45 patients who underwent open heart surgery from January 2016 to June 2016. Both urinary kidney injury molecule 1 and serum creatinine were evaluated before operation and 3hs and 24hs after operation. Acute kidney injury was diagnosed according to Kidney Disease: Improving Globa

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Zeng, Xu, Deloar Hossain, David G. Bostwick, Guillermo A. Herrera та Ping L. Zhang. "Urinary β2-Microglobulin Is a Good Indicator of Proximal Tubule Injury: A Correlative Study with Renal Biopsies". Journal of Biomarkers 2014 (20 листопада 2014): 1–7. http://dx.doi.org/10.1155/2014/492838.

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Objective. After filtration through glomeruli, β2-microglobulin is reabsorbed in proximal tubules. Increased urinary β2-microglobulin indicates proximal tubule injury and measurement of β2-microglobulin in urine is useful to determine the source of renal injury. Kidney injury molecule-1 (KIM-1) has been characterized as a selective proximal tubule injury marker. This study was designed to evaluate the correlation of urinary β2-microglobulin concentration and KIM-1 expression as evidence of proximal tubule injury. Methods. Between 2009 and 2012, 46 patients with urine β2-microglobulin (RenalVys

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Danjuma, Mohammed I., Shaikha Al Shokri, Nadia Bakhsh, Mohammed A. Alamin, Mohamed GH Mohamedali, and Igbiks Tamuno. "The utility of kidney injury molecule-1 as an early biomarker of kidney injury in people living with HIV." International Journal of STD & AIDS 31, no. 13 (2020): 1228–37. http://dx.doi.org/10.1177/0956462420918515.

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There are increasing reports of antiretroviral therapy (ART) drug-related kidney dysfunction. Traditional markers of kidney dysfunction such as urine protein/creatinine ratio and estimated glomerular filtration rate (eGFR) have thus far proven ineffective at detecting some sub-clinical forms of ART-related kidney injury. This is a cross-sectional examination of 114 people living with HIV (PLWH), either naïve ( N =104) or treatment experienced ( N =10). Urinary kidney injury molecule-1 (KIM-1 ng/mg) thresholds were estimated using electrochemiluminescent assays from stored urine samples and nor

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Tian, Lei, Xinghua Shao, Yuanyuan Xie, et al. "Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway." Cellular Physiology and Biochemistry 41, no. 2 (2017): 769–83. http://dx.doi.org/10.1159/000458737.

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Background/Aims: Kidney injury molecule-1 (KIM-1) is highly expressed in renal tubular cells after injury and is usually regarded as an early biomarker of acute kidney injury(AKI). The aim of this study was to determine the role of KIM-1 in the development of renal tubular injury Methods: Clinical samples, three different animal models and in vitro experiments were utilized to determine the possible mechanism underlying the involvement of KIM-1 in kidney injury. Results: Both plasma and urinary KIM-1 expression levels were significantly higher in AKI and chronic kidney disease (CKD) patients t

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Zhao, Wen-Ting, Jun-Wen Huang, Ping-Ping Sun, et al. "Diagnostic roles of urinary kidney injury molecule 1 and soluble C5b-9 in acute tubulointerstitial nephritis." American Journal of Physiology-Renal Physiology 317, no. 3 (2019): F584—F592. http://dx.doi.org/10.1152/ajprenal.00176.2019.

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Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury characterized by inflammatory cells infiltrating in the interstitium. The present study aimed to explore noninvasive biomarkers that might indicate activity of pathological injuries and help direct treatment. Fifty-four patients with clinical-pathologically diagnosed ATIN from January 1, 2014, to June 30, 2016, at Peking University First Hospital were enrolled. Urine samples were collected on the morning of renal biopsy and assessed for urinary kidney injury molecule-1 (KIM-1) and urinary soluble C5b-9 (sC5b-9).

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Bonventre, J. V. "Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more." Nephrology Dialysis Transplantation 24, no. 11 (2009): 3265–68. http://dx.doi.org/10.1093/ndt/gfp010.

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Shahin, Walaa, Ahmed Bader, Rawdah Ahmed, Mona Alattar, Mona Alfalaki, and Walaa Rabie. "Assessment of Urinary Kidney Injury Molecule-1 as an Indicator of Early Renal Insult in Children with Cystic Fibrosis." Open Access Macedonian Journal of Medical Sciences 8, B (2020): 262–67. http://dx.doi.org/10.3889/oamjms.2020.4160.

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BACKGROUND: The risk of acute kidney injury in cystic fibrosis (CF) patients is due to renal tubular affection by CFTR gene. AIM: Our study aimed at early detection of renal impairment in CF patients, to enable careful monitoring and adjustment of nephrotoxic medications. METHODS: Fifty patients with CF were enrolled in our study; they were age- and sex-matched to 40 healthy control children. All subjects were screened by urine analysis, measurements of kidney function tests, fractional excretion of sodium, β2-microglobulin (beta-2-M) excretion, and renal ultrasound examination. Ur

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Shahin, Walaa, Ahmed Bader, Rawdah Ahmed, Mona Alattar, Mona Alfalaki, and Walaa Rabie. "Assessment of Urinary Kidney Injury Molecule-1 as an Indicator of Early Renal Insult in Children with Cystic Fibrosis." Open Access Macedonian Journal of Medical Sciences 8, B (2020): 262–67. http://dx.doi.org/10.3889/oamjms.2020.4160.

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BACKGROUND: The risk of acute kidney injury in cystic fibrosis (CF) patients is due to renal tubular affection by CFTR gene. AIM: Our study aimed at early detection of renal impairment in CF patients, to enable careful monitoring and adjustment of nephrotoxic medications. METHODS: Fifty patients with CF were enrolled in our study; they were age- and sex-matched to 40 healthy control children. All subjects were screened by urine analysis, measurements of kidney function tests, fractional excretion of sodium, β2-microglobulin (beta-2-M) excretion, and renal ultrasound examination. Ur

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Guo, Meiling, Yanjie Li, and Haibo Li. "Predictive value of NGAL and KIM-1 on survivors of acute kidney injury requiring dialysis." European Journal of Inflammation 17 (January 2019): 205873921985683. http://dx.doi.org/10.1177/2058739219856830.

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To investigate the predictive effects of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) on renal-replacement therapy for traumatic acute kidney injury (TAKI). The urinary NGAL and KIM-1 levels of TAKI patients underwent renal-replacement therapy were assessed. The correlation and predictive model were also analyzed. Short-term (28 days) survival rate of patients were 54.5%. As TAKI stage increased, urinary KIM-1 and NGAL level increased significantly ( P < 0.05). The urinary KIM-1 and NGAL level, negatively correlated with 28-day survial, were all hig

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Mineev, V. N., T. S. Vasilieva, A. V. Smirnov, O. V. Galkina, and V. I. Trofi mov. "KIM-1 level in urine with initial reduction of glomerular filtration rate in patients with various bronchial asthma variants." Nephrology (Saint-Petersburg) 25, no. 4 (2021): 64–70. http://dx.doi.org/10.36485/1561-6274-2021-25-4-64-70.

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INTRODUCTION. Previously, we postulated the common pathogenetic mechanisms in bronchial asthma (BA) and chronic kidney disease (CKD). The kidney injury molecule-1 (KIM-1) is considered as an early biomarker of the proximal renal tubules damage. In the available literature, there is only one clinical study of KIM-1 in children BA.THE AIM of the study is to assess KIM-1 levels in different variants of BA.PATIENTS AND METHODS. The 24 BA patients were examined. Glomerular filtration rate (eGFR) by CKD-EPI was calculated. The concentration of the kidney injury molecule -1 (KIM-1) in urine was deter

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Aljorani, Raghda Hisham, Eman Saadi Saleh, and Khalaf Gata Hussein Al Mohammadawi. "Correlation of Kidney Injury Molecule-1 and Nephrin Levels in Iraqi Patients with Diabetic Nephropathy." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 5 (July 30, 2023): 99–104. http://dx.doi.org/10.54133/ajms.v5i.167.

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Background: Diabetic nephropathy is characterized by persistent microalbuminuria and metabolic changes that decline renal functions. Researchers have been prompted to explore new biomarkers such as KIM-1 and nephrin that may enhance the identification of disease. Objective: To Evaluate biomarker levels of kidney injury molculre-1 (KIM-1) concentration and nephrin as early and sensitive markers of nephropathy in type 2 diabetic patients. Method: One hundred T2DM patients were included in a cross-sectional study at the specialized center for endocrinology and diabetes, Baghdad. The first group i

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Geng, Like, Qun Dang, Guo Lv, Luzhao Wang, and Sanjun He. "Effect of urinary kidney injury molecule-1 levels on short-term prognosis of chronic heart failure." Journal of the Pakistan Medical Association 73, no. 10 (2023): 1973–77. http://dx.doi.org/10.47391/jpma.7428.

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Objective: To explore the influential elements of urinary kidney injury molecule-1 levels in chronic heart failure, and to judge its ability to predict 90-day rehospitalisation. Method: The cross-sectional case-control study was conducted from November 2020 to April 2021, at Hanzhong Central Hospital, China, and comprised adult patients having chronic heart failure with normal renal function in group A and healthy subjects in control group B. Patients in group A received anti-heart failure therapy for 1 week in hospital and were followed up for 90 days after discharge. Blood pressure (BP), kid

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Musiał, Kinga, Monika Augustynowicz, Izabella Miśkiewicz-Migoń, Krzysztof Kałwak, Marek Ussowicz, and Danuta Zwolińska. "Clusterin as a New Marker of Kidney Injury in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Pilot Study." Journal of Clinical Medicine 9, no. 8 (2020): 2599. http://dx.doi.org/10.3390/jcm9082599.

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Background and aims: The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney injury molecule (KIM)-1) and functional (cystatin C) markers. Material and methods: Serum and urinary clusterin, KIM-1 and cystatin C concentrations were assessed by ELISA in 27 children before alloHSCT, 24 h, 1, 2, 3 and 4 weeks after alloHSCT and in controls. Results: All paramet

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Sandelius, Åsa, Jayati Basak, Mikko Hölttä, et al. "Urinary Kidney Biomarker Panel Detects Preclinical Antisense Oligonucleotide-Induced Tubular Toxicity." Toxicologic Pathology 48, no. 8 (2020): 981–93. http://dx.doi.org/10.1177/0192623320964391.

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Sensitive kidney safety assessment is important for successful drug development in both preclinical and clinical stages. The Food and Drug Administration recently qualified a composite measure of 6 urine creatinine-normalized biomarkers, such as clusterin, cystatin C, kidney injury molecule 1 (KIM-1), N-acetyl-β-d-glucosaminidase, neutrophil gelatinase-associated lipocalin (NGAL), and osteopontin, for monitoring kidney toxicity in early clinical trials. The qualification was based on small molecule drugs in humans, and the full panel has not been assessed in other species or for other drug mod

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Demir, Ayşegül Doğan, Nilufer Goknar, Faruk Oktem та ін. "Renal tubular function and urinary N-acetyl-β-d-glucosaminidase and kidney injury molecule-1 levels in asthmatic children". International Journal of Immunopathology and Pharmacology 29, № 4 (2016): 626–31. http://dx.doi.org/10.1177/0394632016651448.

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Background: Asthma is a chronic inflammatory disorder of the airways which results in chronic hypoxia. Chronic hypoxia and inflammation can affect renal tubular function. Objectives: The aim of this study was to investigate renal tubular function and early kidney injury molecules such as urinary N-acetyl-betaglucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) excretion in children with asthma. Methods: Enrolled in the study were 73 children diagnosed with asthma and 65 healthy age- and gender-matched control subjects. Urine pH, sodium, phosphorus, potassium, microalbumin, creatinine, NA

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Hong, Ming-Yuan, Chin-Chung Tseng, Chia-Chang Chuang, Chia-Ling Chen, Sheng-Hsiang Lin, and Chiou-Feng Lin. "Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis." Mediators of Inflammation 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/381358.

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Conventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known. In this study, we showed that elevated urinary MIF levels accompanied the development of AKI during kidney infection in patients with acute pyelone

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Cuesta, Cristina, Isabel Fuentes-Calvo, Sandra M. Sancho-Martinez, et al. "Urinary KIM-1 Correlates with the Subclinical Sequelae of Tubular Damage Persisting after the Apparent Functional Recovery from Intrinsic Acute Kidney Injury." Biomedicines 10, no. 5 (2022): 1106. http://dx.doi.org/10.3390/biomedicines10051106.

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Acute kidney injury (AKI) poses an increased risk factor for new AKI episodes, progression to chronic kidney disease, and death. A worsened evolution has been linked to an incomplete renal repair beyond the apparent functional recovery based on plasma creatinine (pCr) normalization. However, structural sequelae pass largely unnoticed due to the absence of specific diagnostic tools. The urinary kidney injury molecule 1 (KIM-1) participates in renal tissue damage and repair and is proposed as a biomarker of early and subclinical AKI. Thus, we study in this paper the evolution of KIM-1 urinary ex

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Pereira, Mariana Elisa, Darlan Henrique Canei, Yolanda Paim Arruda Trevisan, et al. "Urinary NGAL and KIM-1 in Canine Monocytic Ehrlichiosis." Veterinary Sciences 12, no. 2 (2025): 105. https://doi.org/10.3390/vetsci12020105.

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Glomerulonephritis, caused by the deposition of immune complexes, can lead to kidney damage in dogs with canine monocytic ehrlichiosis (CME). The early diagnosis of renal insult is important to prevent severe kidney disease in infected dogs by Ehrlichia canis. This study aimed to investigate urinary biomarkers of renal function, neutrophil gelatinase (uNGAL), and kidney injury molecule-1 (uKIM-1) using the Luminex® xMAP® platform, and the proportion of mixed or high molecular weight proteinuria in dogs with CME. This study included blood samples of thirty dogs with clinical signs of CME and am

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MUNAZZA YASMEEN, SUMBLA GHAZNAVI, HAFIZ MOHAMMAD KHALID MEHMOOD, and NADIA AWAN. "COMPARISON OF URINARY KIDNEY INJURY MOLECULE1/CREATININE RATIO IN PATIENTS WITH RENAL STONE SIZE 5 MM - 20 MM." Pakistan Postgraduate Medical Journal 26, no. 2 (2015): 34–37. http://dx.doi.org/10.51642/ppmj.v26i2.154.

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Introduction: Urolithiasis ( stone formation in urine) is a common disease that affects the excretory system of urine in all age groups. Urolithiasis may be associated with complications such as infection, obstructive uropathy leading to acute renal failure, chronic kidney damage and in the worst scenario, to the loss of a kidney. Methodology: In this study, KIM-1 was measured in patients who were divided into three groups - A comprising controls(without renal stone), B contained patients each of whom having been suffering from renal stone size 5 to 10.9mm, C composed of patients having

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Saeedi Ghaheh, Maryam, Saeed Mardani, Afsaneh Malekpour, et al. "Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery." Journal of Nephropharmacology 10, no. 1 (2020): e04-e04. http://dx.doi.org/10.34172/npj.2021.04.

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Introduction: Serum creatinine level is currently being used as an indicator to detect acute kidney injury (AKI) after cardiac surgery, which is delayed and unreliable. Objectives: This study was conducted to determine the AKI in patients undergoing coronary artery bypass graft (CABG) surgery by measurement of urinary creatinine and plasma kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Patients and Methods: In this cross-sectional study, 96 patients undergoing CABG were divided based on their serum creatinine level of the fourth day after procedure into t

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Ghadrdan, Elliyeh, Sholeh Ebrahimpour, Sanambar Sadighi, Samira Chaibakhsh, and Zahra Jahangard-Rafsanjani. "Evaluation of urinary neutrophil gelatinase-associated lipocalin and urinary kidney injury molecule-1 as biomarkers of renal function in cancer patients treated with cisplatin." Journal of Oncology Pharmacy Practice 26, no. 7 (2020): 1643–49. http://dx.doi.org/10.1177/1078155220901756.

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Introduction Cisplatin-associated acute kidney injury (AKI) is the major limitation to the use of cisplatin-based chemotherapy regimens. Serum creatinine as a traditional marker did not increase in a timely enough fashion in AKI patients. Therefore, recently, the novel markers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) were considered for early detection of AKI. The aim of this study was to compare the sensitivity and specificity of urinary NGAL and KIM-1 with serum creatinine in cisplatin related AKI. Methods Patients ≥18 years with solid tu

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SAMIR K. ABDUL-HAMID, M.D., SALWA S. EL-GENDI, M. D. ;., and ASMAA O. AHMED, M. D. ;. SALMA M. MOHAMMED, M.Sc. "Urinary Kidney Injury Molecule 1 (U-KIM-1) as a Predictor of Lupus Nephritis." Medical Journal of Cairo University 86, no. 9 (2018): 2621–31. http://dx.doi.org/10.21608/mjcu.2018.58066.

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Gu, Yi-Zhong, Larry Handt, Katerina Vlasakova, et al. "Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling." Toxicologic Pathology 50, no. 1 (2021): 35–46. http://dx.doi.org/10.1177/01926233211049171.

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Kidney biopsies are used sparingly to diagnose kidney injury in the clinic. Here we have conducted a small exploratory study to directly compare the low-grade kidney injury monitoring performance of serum safety biomarkers, novel urine safety biomarkers, microscopic histopathology and targeted gene expression alterations in kidney biopsy specimens in rhesus monkeys treated with tobramycin. Targeted gene expression increases were observed in the kidney biopsy samples and whole kidney sections for kidney injury molecule 1 ( KIM-1), clusterin ( CLU), osteopontin ( OPN) messenger RNA transcripts.

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Mohammed Abdullah Ajeel and Zaid Mohammed Mubarak Al-Mahdawi. "The Relation between Kidney Injury Molecule -1 and its role as promising biomarker in kidney stone patients." Tikrit Journal of Pure Science 23, no. 8 (2018): 26–29. http://dx.doi.org/10.25130/tjps.v23i8.539.

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Urea and creatinine is the most sensitive markers of Kidney Diseases progression in clinical practice, especially when combined with GFR, but these have limitations. Hence, early, more sensitive, biomarkers are required. Recently, promising biomarkers have been identified for CKD progression such as kim-1 has been investigated as a novel biomarkers of kidney diseases progression. This study aimed to evaluate urinary Kidney Injury Molecule-1(KIM-1) in kidney stone patients.75 patients diagnosed with renal stone diseases and all patients were screened and followed up in the out-patients clinics

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McMahon, Kelly R., Hayton Chui, Shahrad Rod Rassekh, et al. "Urine Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 to Detect Pediatric Cisplatin-Associated Acute Kidney Injury." Kidney360 3, no. 1 (2021): 37–50. http://dx.doi.org/10.34067/kid.0004802021.

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BackgroundFew studies have described associations between the AKI biomarkers urinary neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) with AKI in cisplatin-treated children. We aimed to describe excretion patterns of urine NGAL and KIM-1 and associations with AKI in children receiving cisplatin.MethodsParticipants (n=159) were enrolled between 2013 and 2017 in a prospective cohort study conducted in 12 Canadian pediatric hospitals. Participants were evaluated at early cisplatin infusions (at first or second cisplatin cycle) and late cisplatin infusions (la

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Lee, Hahn-Ey, Sun Hee Lee, Minki Baek, Hwang Choi, and Kwanjin Park. "Urinary Measurement of Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 Helps Diagnose Acute Pyelonephritis in a Preclinical Model." Journal of Biomarkers 2013 (December 14, 2013): 1–6. http://dx.doi.org/10.1155/2013/413853.

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Background. The study assessed whether measurement of urinary biomarkers of acute kidney injury could be helpful in diagnosing acute pyelonephritis and subsequent scarring. Method. Escherichia coli J96 (0.3 mL inoculum containing 1×109/mL) was directly injected into the renal cortex of 3-week-old female Sprague Dawley rats (n=20), with saline substituted in a control group (n=10). Following the injection, urine was collected 2, 7, 14, 28, and 42 days after injection. Urinary neutrophil gelatinase associated lipocalin (NGAL), kidney injury molecule-1 (Kim-1), and interleukin-18 were quantitativ

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Bano, Gulnaz, Mohammad Tarique Imam, Ram Bajpai, et al. "Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study." Journal of Personalized Medicine 13, no. 4 (2023): 577. http://dx.doi.org/10.3390/jpm13040577.

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The purpose of the study was to examine the urinary levels of kidney injury molecule-1 (KIM-1) and angiopoietin-like protein-4 (ANGPTL-4) in individuals with diabetic kidney disease (DKD) and their association with established DKD diagnostic markers such as albuminuria and estimated glomerular filtration rate (eGFR). Levels of ANGPTL-4 and KIM-1 were estimated in urine samples. A total of 135 participants were recruited into three groups: 45 diabetes type 2 patients in the control group and 90 DKD patients in two disease groups. Concentrations of ANGPTL-4 and KIM-1 were conclusively related to

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Rejeki, Marliana Sri, Wawaimuli Arozal, Rianto Setiabudy, and Djumhana Atmakusuma. "Evaluation of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Urinary Levels for Detecting Kidney Dysfunction in Patients With Nasopharyngeal Cancer Treated With Cisplatin-Based Treatment." Indonesian Journal of Cancer 12, no. 2 (2018): 60. http://dx.doi.org/10.33371/ijoc.v12i2.581.

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Background: Cisplatin has a potency of causing nephrotoxicity. Serum BUN and creatinine levels have been well-known for detecting kidney dysfunction; while KIM-1 and NGAL urine levels are relatively new measurements. The study was aimed to evaluate urinary KIM-1 and NGAL level to detect kidney dysfunction in patients with advanced stage NPC who received cisplatin-based chemotherapy.Methods: The study was a cohort-prospective study with 3 subject groups, i.e. patients who had never received and who had received 75-100 mg/m2 cisplatin-based chemotherapy as well as those who had never received 40

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Ding, Y., L.-M. Nie, Y. Pang, et al. "Composite urinary biomarkers to predict pathological tubulointerstitial lesions in lupus nephritis." Lupus 27, no. 11 (2018): 1778–89. http://dx.doi.org/10.1177/0961203318788167.

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Objective This study aimed to evaluate the clinical value of urinary biomarkers including kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemoattractant protein-1 (MCP-1) in lupus nephritis. Methods A total of 109 biopsy-proven lupus nephritis patients were included and 50 healthy individuals were used as normal controls. Urinary KIM-1, NGAL, and MCP-1 levels were measured by ELISA and their correlations with clinical and histological features were assessed. Receiver operating characteristic curves were performed and the Cox regression model w

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Huang, Jiayan, Ezgi Caliskan Guzelce, Shadi K. Gholami, et al. "Effects of Mineralocorticoid Receptor Blockade and Statins on Kidney Injury Marker 1 (KIM-1) in Female Rats Receiving L-NAME and Angiotensin II." International Journal of Molecular Sciences 24, no. 7 (2023): 6500. http://dx.doi.org/10.3390/ijms24076500.

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Kidney injury molecule-1 (KIM-1) is a biomarker of renal injury and a predictor of cardiovascular disease. Aldosterone, via activation of the mineralocorticoid receptor, is linked to cardiac and renal injury. However, the impact of mineralocorticoid receptor activation and blockade on KIM-1 is uncertain. We investigated whether renal KIM-1 is increased in a cardiorenal injury model induced by L-NAME/ANG II, and whether mineralocorticoid receptor blockade prevents the increase in KIM-1. Since statin use is associated with lower aldosterone, we also investigated whether administering eiSther a l

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Kanukoev, K. Yu, N. S. Sergeeva, T. A. Karmakova, et al. "KIM-1 (kidney injury molecule 1) in the urine of renal cell carcinoma patients." Cancer Urology 16, no. 3 (2020): 21–28. http://dx.doi.org/10.17650/1726-9776-2020-16-3-21-28.

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Objective: to assess the potential clinical significance of KIM-1 (kidney injury molecule 1) as a urinological marker for kidney cancer.Materials and methods. An enzyme-linked immunosorbent assay was used to assess urinary KIM-1 (uKIM-1 — kidney injury molecule 1) levels in 67 patients with renal cell carcinoma (RCC) and 36 healthy volunteers (a control group).Results. Both in patients and in healthy individuals, uKIM-1 levels were age independent. A difference between mean uKIM-1 values in RCC patients (2.4 ± 0.2 ng/ml) and the control group (0.7 ± 0.1 ng/ml) was statistically significant (p

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Barreto, R., C. Fagundes, R. Moreira, et al. "1018 URINARY KIDNEY INJURY MOLECULE-1 (KIM-1) IN THE ASSESSMENT OF ACUTE KIDNEY INJURY IN PATIENTS WITH CIRRHOSIS." Journal of Hepatology 58 (April 2013): S419. http://dx.doi.org/10.1016/s0168-8278(13)61019-3.

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Nan-ya, Ken-ichiro, Masatomo Kajihara, Natsuki Kojima, and Masakuni Degawa. "Usefulness of urinary kidney injury molecule-1 (Kim-1) as a biomarker for cisplatin-induced sub-chronic kidney injury." Journal of Applied Toxicology 35, no. 2 (2014): 124–32. http://dx.doi.org/10.1002/jat.2999.

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Ashida, Chisato, Yuji Nozaki, Jinhai Li, et al. "Urinary Kim-1 Correlates with Interstitial Nephritis Activity in Patients with Microscopic Polyangiitis." Current Issues in Molecular Biology 47, no. 3 (2025): 196. https://doi.org/10.3390/cimb47030196.

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Background: Microscopic polyangiitis (MPA) is a type of necrotizing vasculitis that primarily affects small vessels and belongs to the spectrum of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs). While previous studies have identified potential prognostic biomarkers, further research is needed to validate a reliable marker for risk stratification in clinical practice. Kidney injury molecule-1 (Kim-1), a transmembrane protein expressed on proximal tubular epithelial cells, has been implicated in tubular damage. This study investigated the potential of Kim-1 as a bioma

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Kuzmin, O. B., V. V. Zhezha, V. V. Belaynin, N. V. Buchneva, L. N. Landar, and S. V. Serdyuk. "DIAGNOSTIC AND PROGNOSTIC VALUE OF RENAL TUBULAR INJURY BIOMARKERS NGAL, KIM-1, L-FABP IN CHRONIC KIDNEY DISEASE PATIENTS." Nephrology (Saint-Petersburg) 21, no. 2 (2017): 24–32. http://dx.doi.org/10.24884/1561-6274-2017-21-2-24-32.

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The review summarized data on the diagnostic and prognostic value of biomarkers of kidney injury NGAL (neutrophil gelatinaseassociated lipocalin), KIM-1 (kidney injury molecule-1) and L-FABP (liver type fatty acid-binding protein) in patients with CKD. The most studied of these is NGAL, increase of its level in urine reflects the severity of CKD. Elevated levels of urinary NGAL evaluated also as a prognostic criterion which allows identifying patients with high risk of unfavorable course of disease. Elevated levels of urinary KIM-1 inpatients with CHF can detect individuals with tubulointersti

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Kramer, Andrea B., Mirjan M. van Timmeren, Theo A. Schuurs, et al. "Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time." American Journal of Physiology-Renal Physiology 296, no. 5 (2009): F1136—F1145. http://dx.doi.org/10.1152/ajprenal.00541.2007.

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Tubulointerstitial lesions are important in the progression of proteinuric renal disease. Tubular kidney injury molecule-1 (Kim-1) is induced in acute renal injury and reversible as a natural course. Kim-1 is also present in chronic renal damage; however, the dynamics of Kim-1 in chronic renal damage and effects of antiproteinuric treatment on Kim-1 are unknown. We studied Kim-1 in adriamycin nephrosis (AN) before and after renin-angiotensin system blockade. A renal biopsy was taken 6 wk after adriamycin injection to study renal damage and Kim-1 expression. Subsequently, ACE inhibition (ACEi;

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Abed Kadhem, Ahmed, Qutaiba Samir Sabea, Anmar Jabbar Maftool, and Ali Adil Murtadha. "The Role of Kidney Injury Molecule-1(KIM-1) In Early Location Nephropathy of Iraqi Diabetic Patients." Osol Journal for Medical Sciences 3, no. 1 (2025): 1–9. https://doi.org/10.69946/ojms/2025.03.001.

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Background: Serum KIM1 is the most effective diagnostic method for type 2 diabetes with microalbuminuria (increasing the level of albumin in urine). About 50% of diabetics develop diabetic nephropathy, which is another typical consequence of hyperglycemia. Objective: This study evaluates the impact of serum renal damage in the initial stages of diabetic nephropathy. Study design: The current study was conducted at the Department of Medical Laboratories at Osol AL- Elm University and Baghdad Hospital in the Medical City between December 2023 and June 2024. There were 90 participants in the tria

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Tsai, Kai-Fan, Pai-Chin Hsu, Chien-Te Lee, et al. "Association between Enzyme-Linked Immunosorbent Assay-Measured Kidney Injury Markers and Urinary Cadmium Levels in Chronic Kidney Disease." Journal of Clinical Medicine 11, no. 1 (2021): 156. http://dx.doi.org/10.3390/jcm11010156.

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Cadmium exposure is associated with chronic kidney disease (CKD), but the optimal biomarker for early cadmium-associated nephrotoxicity in low-level exposure has not yet been established. We conducted a cross-sectional investigation involving 167 CKD patients stratified according to tertiles of urinary cadmium levels (UCd), in which enzyme-linked immunosorbent assay (ELISA)-measured novel renal biomarkers were utilized to assess the extent of renal injury associated with cadmium burden. In the analyses, urinary kidney injury molecule-1 (KIM-1) levels and age were the independent factors positi

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Ahn, Moon Bae, Kyoung Soon Cho, Seul Ki Kim, et al. "Poor Glycemic Control Can Increase the Plasma Kidney Injury Molecule-1 Concentration in Normoalbuminuric Children and Adolescents with Diabetes Mellitus." Children 8, no. 5 (2021): 417. http://dx.doi.org/10.3390/children8050417.

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Diabetic nephropathy (DN) is a serious microvascular complication in childhood diabetes and microalbuminuria has been a solid indicator in the assessment of DN. Nevertheless, renal injury may still occur in the presence of normoalbuminuria (NA) and various tubular injury biomarkers have been proposed to assess such damage. This case-controlled study aimed to evaluate plasma and urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 (KIM-1) levels in diabetic children particularly in those with normo- and high-NA stages and determine their role in predicting DN. Fifty-f

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Kin Tekce, Buket, Hikmet Tekce, Gulali Aktas, and Mustafa Sit. "Evaluation of the Urinary Kidney Injury Molecule-1 Levels in Patients With Diabetic Nephropathy." Clinical & Investigative Medicine 37, no. 6 (2014): 377. http://dx.doi.org/10.25011/cim.v37i6.22242.

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Purpose: Kidney Injury Molecule-1 is a protein that increases in urine following tubular damage. Kidney Injury Molecule-1 levels were correlated with the level of chronic kidney disease secondary to diabetic nephropathy in patients with type 2 Diabetes Mellitus. Methods: Clinical and laboratory findings of 142 patients with diabetic nephropathy and 34 control subjects were analysed. Creatinine and HbA1c levels in blood samples and albumin, creatinine and Kidney Injury Molecule-1 levels in urine samples were assessed. Results: Urinary Kidney Injury Molecule-1 levels were significantly increased

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Guarda, Naiara S., Yãnaí S. Bollick, José Antonio M. de Carvalho, Melissa O. Premaor, Fabio V. Comim, and Rafael N. Moresco. "High Serum Uric Acid Is Associated with Tubular Damage and Kidney Inflammation in Patients with Type 2 Diabetes." Disease Markers 2019 (April 11, 2019): 1–9. http://dx.doi.org/10.1155/2019/6025804.

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Background. Uric acid presents different roles in an organism. High serum uric acid concentrations may induce inflammatory pathways and promote kidney damage through different mechanisms. Therefore, this study investigated the association among high serum uric acid concentrations, renal tubular damage, and renal inflammation assessed via estimation of urinary kidney injury molecule-1 (KIM-1) and inflammatory cytokines in patients with type 2 diabetes (T2D). Methods. Urinary concentrations of KIM-1, IL-1, IL-6, IL-10, and TNF-alpha, as well as other biochemical parameters, were assessed in 125

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McDuffie, James Eric, Jing Ying Ma, Marciano Sablad, et al. "Time Course of Renal Proximal Tubule Injury, Reversal, and Related Biomarker Changes in Rats Following Cisplatin Administration." International Journal of Toxicology 32, no. 4 (2013): 251–60. http://dx.doi.org/10.1177/1091581813493013.

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Cisplatin (CDDP) is known to produce renal proximal tubule injury. Various renal biomarkers have been related to CDDP nephrotoxicity in previous research, but the temporal and spatial relationship of these biomarkers to injury reversal has not been well defined. In this study, the progression and reversal of renal histopathology findings relative to serum and urinary biomarker changes were examined during a 4-week postdose period following single intraperitoneal administration of CDDP (1 mg/kg) or 0.9% saline. Degeneration, vacuolation, inflammation, and regeneration of the S3 segment of proxi

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Sivertsson, Ebba, Malou Friederich-Persson, Carl M. Öberg, et al. "Inhibition of mammalian target of rapamycin decreases intrarenal oxygen availability and alters glomerular permeability." American Journal of Physiology-Renal Physiology 314, no. 5 (2018): F864—F872. http://dx.doi.org/10.1152/ajprenal.00033.2017.

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An increased kidney oxygen consumption causing tissue hypoxia has been suggested to be a common pathway toward chronic kidney disease. The mammalian target of rapamycin (mTOR) regulates cell proliferation and mitochondrial function. mTOR inhibitors (e.g., rapamycin) are used clinically to prevent graft rejection. mTOR has been identified as a key player in diabetes, which has stimulated the use of mTOR inhibitors to counter diabetic nephropathy. However, the effect of mTOR inhibition on kidney oxygen consumption is unknown. Therefore, we investigated the effects of mTOR inhibition on in vivo k

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