To see the other types of publications on this topic, follow the link: Uterine fibroids.
Journal articles on the topic 'Uterine fibroids'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Uterine fibroids.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Nadir qızı Kərimova, Sevinc. "Uterine fibroids." NATURE AND SCIENCE 07, no. 02 (April 23, 2021): 22–24. http://dx.doi.org/10.36719/2707-1146/07/22-24.
Full textAbstract:
Fibroids (especially large ones) deform the uterine cavity, compressing the fallopian tubes, making it difficult for sperm to move. In addition, in women with fibroids, in many cases, the hormonal background is disturbed, as a result of which a woman may not ovulate. The factors we have listed can lead to infertility in women. Doctors recommend women with fibroids to treat fibroids during the planning stage of pregnancy or, in some cases, to remove fibroids before pregnancy. A woman can plan a pregnancy 6 months after the fibroid is removed. Key words: fibroma, uterus, pregnancy
2
Golubka, Paweł, Agnieszka Wańkowicz, Marian Przylepa, Marek Gogacz, Ivan Golubka, Kristiana Golubka, Dominik Dłuski, Wiktoria Golubka, and Dorota Darmochwał-Kolarz. "Pregnant women suffering from uterine fibroids." Polish Journal of Public Health 125, no. 3 (September 1, 2015): 166–68. http://dx.doi.org/10.1515/pjph-2015-0047.
Full textAbstract:
Abstract Introduction. Uterine fibroids are the most frequent benign tumors affecting sexual organs in women. It is estimated that they affect 20% of the female population, with the frequency in pregnant women ranging between 0.1-5%. In spite of the progress in the field of medicine, the actual cause of uterine fibroids has yet to be discovered. Aim. Analysis of the recent methods of dealing with uterine fibroids during pregnancy. Material and methods. A review of literature about dealing with pregnant, lying-in and parturient women suffering from uterine fibroids. Results. The research studies by Aydeniz, Vergani, Rice showed that cesarean sections are much more frequent in pregnant women with uterine fibroids than in control group (52.9% vs 27.9%; 23% vs 12%; 35.1% vs 21.5%). However, it was shown that the rate of cesarean sections was much higher in women with uterine fibroids located in the lower part of the uterus than in the fundus uteri (respectively 39% and 18%). Also, the rate increased when the diameter of the fibroid exceeded 5 cm, unlike in case of those smaller than 5 cm (respectively 35% and 17%). Conclusions. 1. The number of cesarean sections in women with uterine fibroids is higher than in control group. 2. The frequency of cesarean sections in pregnancies with uterine fibroids depends on their position and size. 3. There is no relationship between the number of complications and the amount of fibroids in pregnant women. 4. There is no agreement concerning the recommendations for removing the fibroid during cesarean section.
3
Carrino, David A., Sam Mesiano, Nichole M. Barker, William W. Hurd, and Arnold I. Caplan. "Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition." Biochemical Journal 443, no. 2 (March 27, 2012): 361–68. http://dx.doi.org/10.1042/bj20111996.
Full textAbstract:
Fibrosis is the formation of excess and abnormal fibrous connective tissue as a result of either a reparative or reactive process. A defining feature of connective tissue is its extracellular matrix, which provides structural support and also influences cellular activity. Two common human conditions that result from fibrosis are uterine fibroids (leiomyomas) and keloid scars. Because these conditions share a number of similarities and because their growth is due primarily to excessive extracellular matrix deposition, we compared the proteoglycans of uterine fibroids and keloid scars with corresponding normal tissues. Our analysis indicates that uterine fibroids and keloid scars contain higher amounts of glycosaminoglycans relative to normal myometrium and normal adult skin respectively. Proteoglycan composition is also different in the fibrotic tissues. Compared with unaffected tissues, uterine fibroids and keloid scars contain higher relative amounts of versican and lower relative amounts of decorin. There is also evidence for a higher level of versican catabolism in the fibrotic tissues compared with unaffected tissues. These qualitative and quantitative proteoglycan differences may play a role in the expansion of these fibroses and in their excessive matrix deposition and matrix disorganization, due to effects on cell proliferation, TGF (transforming growth factor)-β signalling and/or collagen fibril formation.
4
Khan, Maimoona Qadir, Zubeida Akhtar, and Jamila M. Naib. "Uterine Fibroids in Pregnancy." Journal of Gandhara Medical and Dental Science 9, no. 3 (July 1, 2022): 30–33. http://dx.doi.org/10.37762/jgmds.9-3.314.
Full textAbstract:
OBJECTIVES: To determine the maternal and fetal outcomes associated with uterine fibroids in pregnancy. METHODOLOGY: This study was conducted in the Gynaecology Department of Mardan Medical Complex from January 2018 to December 2019. All pregnant women of any age or parity or gestational age with sonographic evidence of uterine fibroids were included. Demographic details, gestational age, symptoms related to fibrosis, size, number and location of the fibroid, mode of delivery, antenatal, intrapartum and postnatal complication, and neonatal outcome were entered in a predesigned proforma. RESULTS: The incidence of uterine fibroids in pregnancy was 0.8%.77 patients were enrolled. The mean age was 26.5 + 3.22 years. The mode of delivery was a caesarean section in 32.4%, and vaginal delivery in 53% of patients.14% of patients miscarried. Fibroids were multiple in 58.4% and single in 41.5% of patients. Submucosal fibroids were seen in 23%, intramural in 18% and subserosal in 58% of cases. The most common maternal complication was abdominal pain (25%), followed by postpartum haemorrhage(23%) and antepartum haemorrhage(19%). Neonatal outcome was good, with 57% of babies being healthy and 9% being admitted to the Neonatal Intensive Care Unit (NICU) and discharged later. CONCLUSION: Pregnant women with fibroids should be cautiously screened during antenatal to avoid obstetric complications.
5
Abdelmtalab, Mohammed A. A., O. Tahir, K. Hussein, and Kamal Badawi. "Anatomical locations of uterine fibroids in Sudanese women." Anatomy Journal of Africa 9, no. 1 (April 5, 2020): 1701–6. http://dx.doi.org/10.4314/aja.v9i1.6.
Full textAbstract:
Uterine fibroids are the commonest uterine neoplasms, they are benign tumors of smooth muscle origin. The study was done to look for the anatomical locations of uterine fibroids and their incidence in Sudanese women at Omdurman Maternity Hospital between 1st July 2014 to 5th October 2015. Their sociodemographic and ultrasound data were collected using a prepared questionnaire. The study included 138 confirmed cases of uterine fibroids out of 2968 investigated cases representing incidence rate of 4.6%. The highest incidence was found in the age group 36-40 years. Most dominant anatomical locations of uterine fibroids were intramural as a single mass (34.78%), followed by the intramural-subserosal in multiple masses (20.29%). The anatomical positions of uterine fibroids, posterior position was seen in (27.5%) which was the most dominant in single uterine fibroid mass, followed by the anterior-posterior position in multiple uterine one (18.1%). Intramural anatomical locations in single mass are the commonest uterine fibroids types which affect the Sudanese women.
Key words: Anatomical locations; Uterine fibroid and leiomyomas
6
Alhainiah, Maha, Elaf Aljifry, Ayman Alghamdi, Lujain Alrabghi, Abdullah Alharbi, Ezdehar Alrowaithi, Fatimah Almuallem, Elaf Fakeih, Bassmah Alrowaithi, and Hassan Allam. "Safety of pregnancy in uterine fibroids." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 8 (July 26, 2018): 2985. http://dx.doi.org/10.18203/2320-1770.ijrcog20182924.
Full textAbstract:
Uterine fibroid is one of the most common intrauterine masses among females at the reproductive age. Pregnancy and uterine fibroids are highly correlated. Pregnancy-related hormones influence the size of uterine fibroids, and fibroids have many impacts on pregnancy. Although most if the uterine fibroids are asymptomatic during pregnancy, serious complications may occur. The main complications include abortion, premature rupture of membranes, premature labor, abruptio placentae, peripartum hemorrhage, fetal malpresentation, fetal intrauterine growth retardation, small for gestational age infants, and fetal anomalies. The main risk factors for complications are related to the fibroid number, size, volume, location, and type. Large, multiple, retroplacental, submucosal, subserosal, pedunculated, or low-lying fibroids carries the highest risk for complications during pregnancy. This review will address the prevalence of uterine fibroids during pregnancy, its effects, and complications.
7
Islam, Dr Md Menhazul, Dr Farzana Alam, Dr Syeeda Showkat, Dr Muhammad Mahbubur Rahman, Dr Mahbuba Shirin, Dr Hafiza Lona, Dr Md Mahbubur Rahman, and Dr Shahjada Selim. "Impact of Vitamin D Supplementation among the Women with Uterine Fibroid in Different Age Groups." Scholars Journal of Applied Medical Sciences 10, no. 11 (November 30, 2022): 2052–56. http://dx.doi.org/10.36347/sjams.2022.v10i11.042.
Full textAbstract:
Background: Uterine fibroid (UF) is a common tumor of the female reproductive system. Though most of the women with fibroids are asymptomatic, approximately 30% of them can mention about some severe symptoms like abnormal uterine bleeding, pelvic pain, anemia, back pain, urinary frequency and even infertility etc. Generally, among the patients with uterine fibroids, prevalence of vitamin D deficiency is found. But, the impact of vitamin D on reduction of the sizes the uterine fibroids are still unknown. Aim of the study: The aim of this study was to assess the impact of vitamin D supplementation among the women with uterine fibroid in different age groups. Methods: This prospective observational study was conducted in the department of Radiology & Imaging, BSMMU, Dhaka, Bangladesh during the period from January 2020 to December 2020. In total 75 women with uterine fibroid were enrolled in this study as study population. Before data collection proper written consents were taken from all the participants. Along with the data regarding fibroids and vitamin D status, all the demographic and clinical data were collected and analyzed. In data collection, a predesigned questioner was used. All data were processed, analyzed and disseminated by using MS Excel and SPSS version 23.0 program as per necessity. Results: In this study, in assessing the fibroid’s sizes of several age group patients, between baseline and follow-up we found that, at baseline, in 20-30, 31-45 and >45 year’s age groups, the mean ±SD sizes of fibroids were 3.32±0.46, 3.91±0.50 and 4.05±0.51 cm respectively. On the other hand, at follow-up stage in those groups the mean ±SD sizes of fibroids were found as 2.64 ±0.40, 3.66±0.48 and 3.5±0.47 cm respectively. Finally, in evaluating the impact of vitamin D supplementation among our participants, comparing the fibroid sizes between baseline and follow-up stages, we observed that, in >45 years’ age group the fibroid size change was non-significant (P<0.05). ..
8
Made Indira Dianti Sanjiwani and I Made Widianantara. "Peranan Resveratrol terhadap Progresivitas Uterine Fibroid." KELUWIH: Jurnal Kesehatan dan Kedokteran 2, no. 2 (June 30, 2021): 102–9. http://dx.doi.org/10.24123/kesdok.v2i2.4189.
Full textAbstract:
Uterine fibroids or leiomyomas are benign neoplasms that occur in the uterus and still become a health problem among women of reproductive age. Predominantly, uterine fibroids are found at productive age but some cases are found after menopause. Based on previous studies, there were 145 cases of uterine fibroids in 2014 and 69.7% were found in women over 40 years. Patients with uterine fibroids show a decreased quality of life with symptoms such as heavy uterine bleeding, pelvic pain, and loss of pregnancy. The pathogenesis of uterine fibroids is still unknown, but genetic factors, cytokines, growth factors, and steroid hormones are weak and play an important role in the development of uterine fibroids. Several studies have shown the effect of resveratrol that can be obtained from grape skins. Resveratrol can reduce extracellular matrix deposition and uterine fibroid cell proliferation. Looking at the induced events then resveratrol is effective in preventing the progression of uterine fibroids.
9
Yadav, Rajni, Isotou Drammeh, and Mahendra Kumar Sahu. "Exploring uterine fibroids and its treatment in current scenario." IP International Journal of Comprehensive and Advanced Pharmacology 8, no. 3 (November 15, 2023): 143–48. http://dx.doi.org/10.18231/j.ijcaap.2023.025.
Full textAbstract:
Uterine Fibroids (leiomyoma) are made of muscle cells and other grow tissues grow in and around of the wall of the uterus. Uterine fibroids benign tumors in women reproduction age worldwide. Many are discovered incidentally on clinically examination. Approximately 30% of women with uterine fibroids will present with severe symptoms, which can include abdominal uterine bleeding, anemia, pelvic pain and constipation. Infertility and recurrent miscarriage may also be symptoms of fibroids, depending on their location and size, especially for sub mucous and intramural myelomas distorting the uterine cavity. Current option for symptomatic fibroid treatment includes expectant medical and surgical management radiology procedures. Ultrasound can be done, when a patient is symptomatic of uterine fibroids. Fibroids are generally classified by their location; intramural fibroids, subserosal fibroids, submucosal fibroids. The cause of uterine fibroids is unknown, But research and clinical experience proposes that genetics, hormonal imbalance, other growth factor and extracellular matrix accumulation could be the contributing factors .Although uterine fibroids are usually not dangerous, they can cause discomfort and lead to complication such as, drop in red blood cell (anemia) which causes fatigue from heavy bleeding. Our aim is to highlight the new treatments and advancements in treating uterine fibroids. Later we have also highlighted the future advancements and innovations that are used in developed countries for same.
10
Poly, Rosemol, Anju Alex, and Usha Christopher. "Wandering Uterine Leiomyoma: A Case Report." International Journal of Research and Review 10, no. 3 (March 10, 2023): 10–12. http://dx.doi.org/10.52403/ijrr.20230303.
Full textAbstract:
Wandering fibroids, commonly referred to as parasitic fibroids, are a relatively uncommon kind of extrauterine benign tumour in women of reproductive age. It has no myometrial connections and frequently develops in conjunction with other abdominopelvic structures' blood supply. Due to their odd placements and symptoms, these fibroids are challenging to diagnose by imaging. There are several hypotheses on the origin of parasitic fibroids, including the iatrogenic seeding of fibroid pieces after morcellation in laparoscopic myomectomy, and pedunculated subserosal fibroid separating from its stalk and joining other abdominopelvic structures. We discuss a case of parasitic fibroid in a 41-year-old nulliparous woman who suffered from abdominal pain and whose usg findings were indicative of an atypical fibroid in this report (broad ligament fibroid).
11
Ugwu, Favour Ebube, and Hyma P. "UTERINE FIBROIDS-A COMPREHENSIVE REVIEW." Journal of Advanced Scientific Research 14, no. 02 (February 28, 2023): 01–08. http://dx.doi.org/10.55218/jasr.202314201.
Full textAbstract:
Uterine fibroid is a non-cancerous growth in the female uterus of a reproductive woman, ranging from age 40s andabove. Even though according to research, females of age 20s and 30s also have few chances of this growth in theiruterus, as long as they have reach a child bearing age (reproductive age); in this stage it is encouraged that such individualis treated with immediate effect to avoid the continuous multiplication of this growth. “Uterine fibroid embolism” can bea good choice for treatment, which is a minimally invasive technique. In other cases, where the fibroid case hasmultiplied so much,” myomectomy”, “hysterectomy” or “laparoscopy” can be considered to remove the fibroid growthand/or remove the uterus entirely if the woman is no more interested to bear child or in the case that removal of theuterus, could terminate the fibroid permanently. According to research, it has been discovered that uterine fibroids affectBlack women more (about 80%) than white women (about 70-75%). Various risk factors that causes fibroids includes;family history, smoking, vitamin D deficiency etc. Avoiding junk foods, avoiding foods rich in fats, avoid high caffeineand High sugary food is also a very good health lifestyle to avoid or maintain proper healthy lifestyle against UFs.Mifepristone, Asoprisnil (ASP), telapristone are good pharmaceutical formulation for maintenance of UFs. UFs tends todecrease its multiplication in the therapy of gonadotropin releasing hormone agonist (GnRH). Some of the classificationsof uterine fibroids includes; Intramural fibroid, Submucosal fibroid, Sub-serosal fibroid, Cervical fibroids etc.
12
Dobrokhotova, Yu E., and I. Yu Ilina. "Uterine fibroids in premenopausal women." Medical Council, no. 13 (October 10, 2019): 123–28. http://dx.doi.org/10.21518/2079-701x-2019-13-123-128.
Full textAbstract:
Uterine fibroids are one of the commonest benign pelvic tumours with an estimated incidence of 20–40% in women during their reproductive years. Incidence rates for uterine fibroid diagnoses were highest in premenopausal age. The gynecologists are frequently faced with need for the administration of menopausal hormone therapy (MHT) in this group of patients with the onset of symptoms associated with estrogen deficiency; however, uterine fibroids represent a relative contraindication for the administration of MHT. In the present paper, we point out the need for conservative therapy of uterine fibroids in premenopausal patients to prepare for the administration of MHT. The paper reflects the efficacy of the drug treatment of uterine fibroids using antigestagens (gynestril).
13
Tskhay, V. B., S. Zh Badmaeva, A. N. Narkevich, I. I. Tskhay, and A. V. Mikhaylova. "A predictive model for calculating the likelihood of recurrent uterine fibroids after surgical intervention." Fundamental and Clinical Medicine 6, no. 3 (September 26, 2021): 64–70. http://dx.doi.org/10.23946/2500-0764-2021-6-3-64-70.
Full textAbstract:
Aim. To develop a predictive model for calculating the likelihood of recurrent uterine fibroids after myomectomy.Materials and Methods. We consecutively recruited 149 women aged 19 to 45 years who underwent myomectomy. Prediction of uterine fibroids was carried out using multivariate analysis including a classification tree (IBM SPSS Statistics). To construct a classification tree for predicting recurrent uterine fibroids, the following patient-related parameters were used as the input features: age, family history, nulliparity, past medical history of myomectomy, obesity, rapid fibroid growth, multiple fibroids at myomectomy, BCL-2, Ki-67, and VEGF expression.Results. When analyzing the resulting classification tree, we can conclude that the most significant factors defining the recurrence of uterine fibroids are low parity, multiple fibroids at myomectomy, intensive VEGF expression, and weak expression of BCL-2.Conclusion. Our original model allows the identification of the most significant predictors of recurrent uterine fibroids and might be proposed as a useful tool for clinical practice.
14
Kanwar, Pushp, Mahesh Dixit, and Narendra Kumar Meena. "A Literary Review of Garbhashayarbuda in Ayurveda w.s.r. to Uterine Fibroid." International Research Journal of Ayurveda & Yoga 05, no. 02 (2022): 105–7. http://dx.doi.org/10.47223/irjay.2022.5218.
Full textAbstract:
Uterine fibroids are most common disease of women in reproductive age. Though uterine fibroids are benign in Nature; they reveal a wide range of symptoms like metrorrhagia, dysmenorrhea, menorrhagia, low back pain etc. Morden treatment protocols include hormonal therapy, myomectomy hysterectomy, and uterine artery embolization. Unwillingness for sustained hormone therapy and panic for surgery brings patients towards to Ayurveda. Ayurveda classics mention various pathological conditions that have features similar to fibroids. Ayurveda it is mandatory to know the correlation of uterine fibroids with Garbhashayarbuda. Arbuda is the disease described in Ayurvedic Samhitas and its corresponds to tumours. The treatment is aimed towards reducing the size of fibroids using Ushna, Tikshna, Lekhana Dravyas along with management of symptoms. So this article focuses on potentials of Ayurveda in management of different aspects of uterine fibroid.
15
Thomas, Lizann Elizabeth, Elizabeth Abraham, and Renjitha Bhaskaran. "Does vitamin D play a role in uterine fibroids? A case control study." Panacea Journal of Medical Sciences 13, no. 2 (July 15, 2023): 323–27. http://dx.doi.org/10.18231/j.pjms.2023.062.
Full textAbstract:
Uterine fibroids are monoclonal tumors of uterine smooth muscle cells. They are found in 20-40% of females in the reproductive age group. Ovarian hormones play an important role in its etiology. Recent studies have shown that low serum 25(OH)vitamin D levels are associated with increased risk of uterine fibroids. To investigate the association between serum vitamin D levels and uterine fibroids.A case control study was conducted in a tertiary care hospital among 183 women between the age of 18-50 years with uterine fibroids who attended obstetrics and gynecology department and 183 women of the same age group who had no uterine fibroids attending comprehensive health checkup clinic. Serum 25(OH)vitamin D levels were estimated in both groups by electrochemiluminescence immunoassay.Statistical analysis was performed using IBM SPSS version 20.0. P value of <0.05 was considered statistically significant. The mean serum 25(OH) vitamin D levels of women with uterine fibroids were 15.03 ± 6.996 ng/mL and 16.629 ± 8.020 ng/mL in women without uterine fibroids. There was no statistically significant difference in serum 25(OH) vitamin D levels between women with and without uterine fibroids (P-0.132).Serum 25(OH) vitamin D levels were found to be deficient in both groups irrespective of the presence or absence of uterine fibroids. Hence, it can be concluded that the study conducted in 366 women could not find a direct association between low serum 25(OH) vitamin D levels and uterine fibroids.
16
Jones, Siân, Peter O'Donovan, and David Toub. "Radiofrequency Ablation for Treatment of Symptomatic Uterine Fibroids." Obstetrics and Gynecology International 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/194839.
Full textAbstract:
The use of thermal energy-based systems to treat uterine fibroids has resulted in a plethora of devices that are less invasive and potentially as effective in reducing symptoms as traditional options such as myomectomy. Most thermal ablation devices involve hyperthermia (heating of tissue), which entails the conversion of an external electromagnetic or ultrasound waves into intracellular mechanical energy, generating heat. What has emerged from two decades of peer-reviewed research is the concept that hyperthermic fibroid ablation, regardless of the thermal energy source, can create large areas of necrosis within fibroids resulting in reductions in fibroid volume, associated symptoms and the need for reintervention. When a greater percentage of a fibroid's volume is ablated, symptomatic relief is more pronounced, quality of life increases, and it is more likely that such improvements will be durable. We review radiofrequency ablation (RFA), one modality of hyperthermic fibroid ablation.
17
Anuradha, R., and G. Rathi. "Presence and Impact of Uterine Fibroids in Women with Menstrual and Premenstrual Syndrome – A Statistical Analysis." International Journal of Membrane Science and Technology 10, no. 2 (August 8, 2023): 3107–13. http://dx.doi.org/10.15379/ijmst.v10i2.3055.
Full textAbstract:
A number of non-invasive alternatives to hysterectomy are available for treating uterine fibroids, but they may not effectively relieve all symptoms. As a result, it has become increasingly important to use patient-reported outcomes to assess the success of these alternative therapies in reducing uterine fibroid symptoms. These symptoms can range from heavy menstrual bleeding to dysmenorrhea for women who experience menstrual and premenstrual syndrome. To standardize the assessment of fibroid-related symptoms, the Uterine Fibroid Indicators and Analysis of Patient Recovery survey form (UFS-APR) was developed as a patient-recovery report analysis. The UFS APR is used to analyze womenfolk with uterine fibroids existing with menstrual and premenstrual syndrome. In our study, we had translated and validated the UFS-APR in India to examine its reliability, correctness, scope, validity and responsiveness in assessing the treatment of uterine fibroids.
18
Micić, Jelena, Maja Macura, Mladen Andjić, Katarina Ivanović, Jelena Dotlić, Dušan D. Micić, Vladimir Arsenijević, et al. "Currently Available Treatment Modalities for Uterine Fibroids." Medicina 60, no. 6 (May 26, 2024): 868. http://dx.doi.org/10.3390/medicina60060868.
Full textAbstract:
Uterine fibroids (leiomyomas and myomas) are the most common benign gynecological condition in patients presenting with abnormal uterine bleeding, pelvic masses causing pressure or pain, infertility and obstetric complications. Almost a third of women with fibroids need treatment due to symptoms. Objectives: In this review we present all currently available treatment modalities for uterine fibroids. Methods: An extensive search for the available data regarding surgical, medical and other treatment options for uterine fibroids was conducted. Review: Nowadays, treatment for fibroids is intended to control symptoms while preserving future fertility. The choice of treatment depends on the patient’s age and fertility and the number, size and location of the fibroids. Current management strategies mainly involve surgical interventions (hysterectomy and myomectomy hysteroscopy, laparoscopy or laparotomy). Other surgical and non-surgical minimally invasive techniques include interventions performed under radiologic or ultrasound guidance (uterine artery embolization and occlusion, myolysis, magnetic resonance-guided focused ultrasound surgery, radiofrequency ablation of fibroids and endometrial ablation). Medical treatment options for fibroids are still restricted and available medications (progestogens, combined oral contraceptives andgonadotropin-releasing hormone agonists and antagonists) are generally used for short-term treatment of fibroid-induced bleeding. Recently, it was shown that SPRMs could be administered intermittently long-term with good results on bleeding and fibroid size reduction. Novel medical treatments are still under investigation but with promising results. Conclusions: Treatment of fibroids must be individualized based on the presence and severity of symptoms and the patient’s desire for definitive treatment or fertility preservation.
19
Winata, I. Gede Sastra, and Nicholas Renata Lazarosony. "Procedures to Reduce Haemorrhage during Myomectomy for Fibroids." Cermin Dunia Kedokteran 49, no. 10 (October 3, 2022): 589–91. http://dx.doi.org/10.55175/cdk.v49i10.312.
Full textAbstract:
Uterine fibroids are the most common solid tumors in the female pelvis. Myomectomy is the first choice of treatment for woman who want to keep their uterus. Haemorrhage, uterine perforation, cervical injury, and metabolic problems from excessive absorption of the distension medium, such as glycine, are risks of hysteroscopic myomectomy. There are several procedures and techniques to reduce haemorrhage during myomectomy for fibroids. Some research demonstrated excellent outcomes with uterine artery ligation. Mioma uteri adalah tumor jinak yang paling sering dijumpai pada wanita. Tindakan miomektomi adalah salah satu pilihan terapi padawanita yang tetap ingin mempertahankan rahim. Perdarahan, perforasi uterus, cedera serviks, dan masalah metabolisme akibat penyerapan berlebihan media distensi, seperti glisin, adalah risiko prosedur histeroskopi miomektomi. Beberapa prosedur dan teknik dapat mengurangi perdarahan saat miomektomi pada kasus mioma uteri. Beberapa penelitian menunjukkan hasil yang sangat baik dengan ligasi arteri uterina.
20
Rawat, Rajneesh, Manik Gedam, Jyoti Baghel, and Shalini Baghel. "A rare association of uterine leiomyoma with mesenteric vein thrombosis and bowel gangrene: case report." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 4 (March 24, 2021): 1721. http://dx.doi.org/10.18203/2320-1770.ijrcog20211167.
Full textAbstract:
Uterine fibroids are the most common benign pelvic tumors in women. There are many complications reported with fibroids. However, mesenteric vein thrombosis and small bowel gangrene caused by a uterine fibroid are rare. This manuscript reports a rare case of 40 year female with a large uterine fibroid associated with mesenteric vein thrombosis and bowel ischemia. She underwent exploratory laparotomy in which resection of gangrenous bowel including jejunum and ileum was done along with left sided jejunostomy and right sided ileostomy. Total abdominal hysterectomy with bilateral salpingooophorectomy was done followed by jejunoileal anastomosis 6 weeks later. Hence, in patients presenting with acute abdomen and uterine fibroids, bowel gangrene must be included in the differential diagnosis.
21
Goswami, Sunita, and Rashmi Sharma. "AN AYURVEDIC REVIEW OF UTERINE FIBROIDS." International Journal of Advanced Research 10, no. 01 (January 31, 2022): 177–81. http://dx.doi.org/10.21474/ijar01/14028.
Full textAbstract:
Uterine fibroidsare the most common solid benign tumours in women of reproductive age. Histologically this tumour is composed of smooth muscle and fibrous connective tissue, called as uterine leiomyoma, myoma, fibromyoma. Uterine fibroid related symptoms negatively impact physical and social activities, womens health related quality of life and work productivity.The postmenopausal incidence, although postmenopausal leiomyomas are smaller and fewer. Though uterine fibroids are non-cancerous in character they exhibit a wide range of symptoms like dysmenorrhea, menorrhagia, metrorrhagia, lower backache. Ayurveda classics mention various pathological conditions that have features similar to fibroids. Owing to its muscular origin, with slow growth may be better compared to Granthi/Arbud in Garbhashaya. In the modern era of busy lifestyle, intake of junk food, lack of exercise etc had led to Agnivaishamya and Aama formation. This in turn vitiates Doshas like Kapha and Vata and Dushyas like Rasa, Raktha, Mamsa, MedasandArthava resulting in Dhatwagnimandya leading to formation of GarbhashayaGranthi.
22
Obiozor AA and Obiozor CG. "Large submucous uterine fibroid mass." Ibom Medical Journal 7, no. 2 (May 1, 2024): 362–64. http://dx.doi.org/10.61386/imj.v7i2.453.
Full textAbstract:
Background: Uterine fibroids or leiomyomas, are common benign tumors originating from the smooth muscle cells of the uterus. While typically asymptomatic, large submucous fibroids can cause significant clinical manifestations, including abnormal uterine bleeding, pelvic pain, and reproductive issues. Radiological imaging, such as ultrasound, played a crucial role in the accurate diagnosis and characterization of these fibroids, guiding appropriate clinical management decisions. Methods: We present a case report of a 28-year-old female with complaints of heavy menstrual bleeding and pelvic discomfort. Clinical evaluation prompted the utilization of radiological imaging techniques to assess the uterine anatomy. Ultrasound was employed to visualize and characterize the large submucous uterine fibroid mass. Imaging findings were correlated with clinical symptoms to formulate an appropriate treatment plan. Results: ultrasound revealed a large submucous uterine fibroid mass measuring 105.7mm x 75.6mm x 79.6mm in its dimensions. The fibroid was heterogeneous in its echo texture and it is located in the submucosal layer of the uterus. Doppler imaging demonstrated some areas of flow within the fibroid mass. The correlation of imaging findings with clinical symptoms aided in determining the extent of fibroid-related symptoms and guiding further management decisions. Conclusion: This case report underscores the significance of radiological imaging, particularly ultrasound in diagnosing and characterizing large submucous uterine fibroid masses. Accurate radiological assessment is crucial for determining the appropriate course of clinical management, which may include medical therapy, minimally invasive procedures, or surgical intervention. The collaborative approach between gynecologists and radiologists is pivotal in optimizing patient care for individuals with symptomatic uterine fibroids.
23
Ahn, Dao Le Thi, Vu Duong Van, Thang Vuong Toan, and Anh Nguyen Duy. "#357 : Uterine Fibroids Treatment Using Radio Frequency Ablation at Hanoi Obstetrics and Gynecology Hospital, Vietnam: A Preliminary Assessment." Fertility & Reproduction 05, no. 04 (December 2023): 538. http://dx.doi.org/10.1142/s2661318223742935.
Full textAbstract:
Complicated uterine fibroids in young women, who wish to preserve fertility, and/ or unwilling to undergo surgery, or those having uterine fibroids deemed difficult for surgical intervention, need a less invasive and effective treatment method. Objectives: To evaluate the results of treatment of uterine fibroids by Radio Frequency Ablation (RFA) at Hanoi Obstetrics and Gynecology Hospital, Vietnam (HOGH) for 8 months. Materials and Methods: A cross-sectional study with longitudinal follow-up. Patients with symptomatic uterine fibroids including abnormal uterine bleeding, pelvic pain, anemia; in need of preserving fertility; without any RFA contra-indications. Results: 18 patients with 20 fibroids were met with the study’s inclusion criteria. The average fibroid size was 4.6±1.3 cm. 77,8% of patients having anemia. Average thermal ablation time was 12.2±4.1 minutes. Fibroids’ size decreased 43.6% after 1 month, 69.6% after 3 months and 83.6% after 6 months. Menstrual disorders and pelvic pain were considerably improved after 1 month and 3 months. Conclusions: RFA had good initial results in reducing fibroids size and improving relating symptoms during the study period.
24
TATARCHUK, T. F., N. V. KOSEY, S. I. REGEDA, O. V. ZANKO, and K. D. PLAKSIIEVA. "TO THE QUESTION ON UTERINE FIBROIDS DURING PREGNANCY." Scientific digest of association of obstetricians and gynecologists of Ukraine, no. 1(47) (September 8, 2021): 54–59. http://dx.doi.org/10.35278/2664-0767.1(47).2021.242698.
Full textAbstract:
Uterine fibroids is an extremely common tumor of the female reproductive system, among whose manifestations are infertility, spontaneous abortions, incorrect fetal position, placenta previa, premature delivery, bleeding during and after delivery, and an increased risk of cesarean section. According to the literature, myomas are changing in size during pregnancy and in the postpartum period. Aim of the study. To assess the dynamics of uterine fibroid size change during pregnancy and the effect of an existing uterine fibroid on the course of pregnancy and labor. Materials and methods. Outpatient records of patients aged 24 to 45 years (mean age 33.36 ± 4.63 years) who were diagnosed with Pregnancy and uterine fibroids from 2016 to 2021 at Verum Medical Center were evaluated (n = 57). The size of the fibroids (volume and diameter) before, during (I or II prenatal screening) and after pregnancy (first pelvic ultrasound after delivery) was used for statistical analysis. Forty-one of the 57 patients had pelvic ultrasound before, during, and after pregnancy and were included in the statistical analysis of changes in uterine myoma size. Results. Among the patients included in the statistical analysis, uterine fibroids increased in volume by 194.38% ± 86.9 (40.98% ± 18.4 in diameter) during pregnancy, and decreased by 53.98% ± 14.93 in diameter and by 54.28% ± 29.62 of baseline in the postpartum period. A significant number of fibroids (39.47%) did undergo involutionary changes and were not visualized in the first postpartum ultrasound. The live birth rate was high at 90% (64% of deliveries were through natural childbirth and 26% through cesarean section). Conclusions. There was no effect of intramural, intramural-subserosal, and subserosal uterine fibroids with an average diameter of £20 mm on pregnancy and live birth in women. A great amount of uterine fibroids nearly triple in size during pregnancy, but after delivery they return to their original size and even halve in size. This can be regarded as a confirmation of the absence of a negative effect of pregnancy, or, possibly, a positive effect on uterine fibroid size, which requires further investigation.
25
R. Podder, Manjiri, Rahul Podder, and Poonam V. Shivkumar. "Demographic parameters of women with uterine fibroids presenting as abnormal uterine bleeding." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 7 (June 27, 2018): 2915. http://dx.doi.org/10.18203/2320-1770.ijrcog20182906.
Full textAbstract:
Background: Uterine fibroids are commonest benign uterine tumors. Only about 25% women with fibroids are symptomatic. Around 70-80% are discovered incidentally during routine pelvic examination. Using ultrasonography screening, some authors have estimated a cumulative incidence of 70% in all women by age 50. Symptoms attributable to fibroids are mainly abnormal uterine bleeding (AUB), pelvic pressure, pain, and reproductive dysfunction. Heavy and/or prolonged menses is the typical bleeding pattern with myomas. Uterine fibroids are a leading cause of hysterectomy in perimenopausal women, thus, this study was done to find out its prevalence and demography in women presenting with AUB. The objectives of the present investigation were to find out the prevalence of uterine fibroid in women with AUB and to find out the various demographic features of womenMethods: The study was done for 2 years in the Dept of Obstetrics and Gynecology of a rural tertiary institute after taking clearance from institutional ethical committee. All the women presenting with AUB were included in the study. History and demographic features was enquired and entered in a predesigned proforma. All women were clinically examined after consent. Women with suspicion of fibroid were subjected to diagnostic modalities and the reports were followed and correlated.Results: Total 11,841 patients came to Gynaeological OPD during the study period. Out of these 3,878 (32.75%) presented with AUB, 2,126 were diagnosed as having fibroids after examination and investigations. Hence, the prevalence of fibroids amongst the women with AUB was 54.82% and 17.95% amongst all gynaecological patients. Maximum women were between 31-40 years, (64.78% rural and 62.73% urban). Majority were having parity between 1-2 (40.73% in urban, 38.96% in rural).Conclusions: Uterine fibroids are the commonest reason of AUB in reproductive age group with the prevalence of 54.82%. The trends in age incidence have remained the same over the years, commonly affecting women in third decade. There is no difference in incidence of fibroids amongst various socioeconomic classes.
26
Hutchins, Francis L. "UTERINE FIBROIDS." Obstetrics and Gynecology Clinics of North America 22, no. 4 (December 1995): 659–65. http://dx.doi.org/10.1016/s0889-8545(21)00659-8.
Full text
27
Bulun, Serdar E. "Uterine Fibroids." New England Journal of Medicine 369, no. 14 (October 3, 2013): 1344–55. http://dx.doi.org/10.1056/nejmra1209993.
Full text
28
Doherty, Leo, Levent Mutlu, Donna Sinclair, and Hugh Taylor. "Uterine Fibroids." Reproductive Sciences 21, no. 9 (May 12, 2014): 1067–92. http://dx.doi.org/10.1177/1933719114533728.
Full text
29
Markowski, Dominique N., Burkhard M. Helmke, Sabine Bartnitzke, Thomas Löning, and Jörn Bullerdiek. "Uterine Fibroids." International Journal of Gynecological Pathology 33, no. 6 (November 2014): 568–72. http://dx.doi.org/10.1097/pgp.0000000000000096.
Full text
30
Stewart, Elizabeth A. "Uterine Fibroids." New England Journal of Medicine 372, no. 17 (April 23, 2015): 1646–55. http://dx.doi.org/10.1056/nejmcp1411029.
Full text
31
Kenney, A., and A. J. Papadopoulos. "Uterine fibroids." Current Obstetrics & Gynaecology 11, no. 5 (October 2001): 285–89. http://dx.doi.org/10.1054/cuog.2001.0197.
Full text
32
Stewart, Elizabeth A. "Uterine fibroids." Lancet 357, no. 9252 (January 2001): 293–98. http://dx.doi.org/10.1016/s0140-6736(00)03622-9.
Full text
33
Hildreth, Carolyn J. "Uterine Fibroids." JAMA 301, no. 1 (January 7, 2009): 122. http://dx.doi.org/10.1001/jama.301.1.122.
Full text
34
Don, Emma E., Mei-An Middelkoop, Wouter J. K. Hehenkamp, Velja Mijatovic, Arjan W. Griffioen, and Judith A. F. Huirne. "Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids—A Systematic Review." International Journal of Molecular Sciences 24, no. 8 (April 10, 2023): 7011. http://dx.doi.org/10.3390/ijms24087011.
Full textAbstract:
Uterine fibroids are the most common benign tumors in women, with abnormal uterine bleeding (AUB) as the main reported symptom. Additionally, an association between fibroids and infertility has been established, especially if the fibroid protrudes in the uterine cavity. Hormonal therapy is associated with side-effects and as well as hysterectomy, which is incompatible with a desire to conceive. To improve treatment, it is essential to unravel the etiology of fibroid-related symptoms. We aim to evaluate endometrial angiogenesis in women with fibroids, with and without AUB, and the influence of pharmaceutical therapies in these patients. Furthermore, we explore the possible role of altered angiogenesis in patients with fibroids and infertility. We performed a systematic review according to PRISMA-guidelines (PROSPERO: CRD42020169061), and included 15 eligible studies. Endometrial expression of vascular endothelial growth factor (VEGF) and adrenomedullin was increased in patients with fibroids. This suggests aberrant angiogenesis, potentially involving disturbed vessel maturation, resulting in immature and fragile vessels. Treatment with gonadotropin-releasing hormone agonist, ulipristal acetate, and continuous oral contraception pills reduced several angiogenic parameters, including VEGF. If infertile and fertile patients with fibroids were compared, a significant decreased expression of the bone morphogenetic protein/Smad-protein pathway was found, possibly caused by the increased expression of transforming growth factor-beta. For future therapeutic development, these different angiogenic pathways could be of interest as possible targets to treat fibroid-related symptoms.
35
Emmanuel Kobina Mesi, Edzie, Dzefi-Tettey Klenam, Brakohiapa Edmund Kwakye, Gorleku Philip Narteh, Aidoo Eric, Amoah Stephen Kwaku, Asiamah Samuel, et al. "Evaluation of the anatomical locations and sizes of uterine fibroids from ultrasound examination in Ghana." African Health Sciences 23, no. 4 (December 27, 2023): 438–50. http://dx.doi.org/10.4314/ahs.v23i4.48.
Full textAbstract:
Background: Uterine fibroids locations and sizes, have significant influences on the quality of life of women especially pregnantwomen and on live birth rate.Objectives: To determine the anatomical locations and sizes of uterine fibroids and assess any possible associations with age groups.Methods: This retrospective study reviewed the locations and sizes of a total of 3,542 patients who were ultrasonographically diagnosed with uterine fibroids from January 2019 to December 2021. The obtained data were analysed using GNU PSPP, and Python on Jupyter Notebook with statistical significance level set at p≤0.05.Results: The overall average diameter of uterine myoma was 5.50±2.60cm (95%CI=5.41–5.58, range=1.00cm–19.10cm) and the respective mean diameter of intramural, subserosal and submucosal fibroids were 5.53±2.60cm (95%CI=5.44–5.62), 5.50±2.27cm (95%CI=5.27–5.74) and 5.82±2.77cm (95%CI=5.49–6.14). Most of the fibroid nodules were small (48.36%, n=1713) and only 5.84% (n=207) were large (>10cm). Posterofundal fibroids and lower anterior myomas were mostly seen in the 35-44 years age class.Conclusion: The majority of the uterine fibroids were intramural and were mostly at the anterior uterine wall. The submucosalfibroids, even though the rarest, were averagely larger than the other types of uterine myomas. The diameter of uterine fibroidsincreased with age.
36
Jamaluddin, M. Fairuz B., Yi-An Ko, Manish Kumar, Yazmin Brown, Preety Bajwa, Prathima B. Nagendra, David A. Skerrett-Byrne, et al. "Proteomic Profiling of Human Uterine Fibroids Reveals Upregulation of the Extracellular Matrix Protein Periostin." Endocrinology 159, no. 2 (December 13, 2017): 1106–18. http://dx.doi.org/10.1210/en.2017-03018.
Full textAbstract:
Abstract The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies, which relate to MED12. We performed extensive genetic and proteomic analyses of clinically annotated fibroids and adjacent normal myometrium to identify the composition and expression patterns of ECM proteins in MED12 mutation–positive and mutation–negative uterine fibroids. Genetic sequencing of tissue samples revealed MED12 alterations in 39 of 65 fibroids (60%) from 14 patients. Using isobaric tagged–based quantitative mass spectrometry on three selected patients (n = 9 fibroids), we observed a common set of upregulated (>1.5-fold) and downregulated (<0.66-fold) proteins in small, medium, and large fibroid samples of annotated MED12 status. These two sets of upregulated and downregulated proteins were the same in all patients, regardless of variations in fibroid size and MED12 status. We then focused on one of the significant upregulated ECM proteins and confirmed the differential expression of periostin using western blotting and immunohistochemical analysis. Our study defined the proteome of uterine fibroids and identified that increased ECM protein expression, in particular periostin, is a hallmark of uterine fibroids regardless of MED12 mutation status. This study sets the foundation for further investigations to analyze the mechanisms regulating ECM overexpression and the functional role of upregulated ECM proteins in leiomyogenesis.
37
Yoon, Sang-Wook, Chan Lee, Kyoung Ah Kim, and Sang Heum Kim. "Contrast-Enhanced Dynamic MR Imaging of Uterine Fibroids as a Potential Predictor of Patient Eligibility for MR Guided Focused Ultrasound (MRgFUS) Treatment for Symptomatic Uterine Fibroids." Obstetrics and Gynecology International 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/834275.
Full textAbstract:
Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a non-invasive treatment approach for symptomatic uterine fibroids. One imaging characteristic considered in selecting patients who may benefit from MRgFUS of their uterine fibroids is the signal intensity of the fibroid compared with surrounding myometrium on T2-weighted MR images. Previous reports suggest that hyper-intense fibroids are less amenable to MRgFUS compared with iso- or hypo-intense fibroids. In this case study, we utilized contrast-enhanced dynamic MR imaging to further characterize the vascularity of a hyper-intense fibroid. Based on the results of dynamic T1-weighted contrast-enhanced images, we assumed that the hyper-intense appearance resulted from high fluid content rather than high vascularity and predicted that the fibroid would respond to MRgFUS. The patient underwent the MRgFUS without complication and reported significant decrease in fibroid symptoms at 3 and 12 months post-treatment. This case suggests that pre-treatment dynamic contrast-enhanced imaging used in conjunction with T2-weighted imaging may improve the criteria for selecting uterine fibroids amenable to treatment with MRgFUS, potentially leading to improved patient outcomes.
38
Rafique, Saima, James Segars, and Phyllis Leppert. "Mechanical Signaling and Extracellular Matrix in Uterine Fibroids." Seminars in Reproductive Medicine 35, no. 06 (November 2017): 487–93. http://dx.doi.org/10.1055/s-0037-1607268.
Full textAbstract:
AbstractFibroids (uterine leiomyomas) are the most common benign tumors of the female reproductive tract. Steroid hormones, growth factors, and cytokines have long been implicated in fibroid growth; however, research suggests that changes in the extracellular matrix and mechanical signaling play a critical role in fibroid growth and differentiation. Studies have shown that growth of fibroids is related to the change in the volume and composition of extracellular matrix with increased deposition of abnormal collagen, glycoproteins, laminins, fibronectins, and an increased osmotic stress. These changes generate mechanical stress which is converted to chemical signals in the cells through mechanotransduction and eventually affects gene expression and protein synthesis. Current studies also suggest that mechanical signaling in fibroid cells is abnormal as evidenced by decreased apoptosis of abnormal cells and deposition of a stiff extracellular matrix promoting fibrosis. Understanding and defining these mechanisms could help design new therapies for the treatment of fibroids.
39
Dubinskaya, E. D., S. N. Kolesnikova, E. V. Aleshkina, and A. S. Gasparov. "Chronic sterile inflammation in the pathogenesis of benign myometrial diseases." Voprosy ginekologii, akušerstva i perinatologii 23, no. 1 (2024): 84–93. http://dx.doi.org/10.20953/1726-1678-2024-1-84-93.
Full textAbstract:
This article presents an analysis of current literary sources on the role of chronic sterile inflammation in the development of proliferative diseases of the myometrium (adenomyosis, uterine fibroids). DAMPs (damage-associated molecular patterns) are considered as a significant marker of inflammation severity in these diseases. The pathogenesis of both uterine fibroids and adenomyosis is based on similar mechanisms related to chronic sterile inflammation in response to abnormal cell division. Neoangiogenesis, neoneurogenesis and fibrosis are likely to be the result of inflammation and contribute to the progression of pathological process, as well as determine its clinical manifestations (pain, heavy menstrual bleeding, infertility, miscarriage, etc.). The development of a particular pattern of pathological processes (uterine fibroids or adenomyosis) is determined by genetic and epigenetic mechanisms. Further studies of proliferative diseases of the myometrium should examine in more detail the systemic immune profile and cellular composition of the myometrium, uterine fibroids and adenomyosis to better understand the role of chronic inflammatory processes in the pathogenesis of myometrial proliferative diseases. Key words: chronic sterile inflammation, DAMPs, adenomyosis, uterine fibroids, fibrosis
40
Winata, I. Gede Sastra, and Nicholas Renata Lazarosony. "Procedures to Reduce Haemorrhage during Myomectomy for Fibroids." Cermin Dunia Kedokteran 49, no. 10 (October 3, 2022): 589. http://dx.doi.org/10.55175/cdk.v49i10.2076.
Full textAbstract:
<p>Uterine fibroids are the most common solid tumors in the female pelvis. Myomectomy is the first choice of treatment for woman who want to keep their uterus. Haemorrhage, uterine perforation, cervical injury, and metabolic problems from excessive absorption of the distension medium, such as glycine, are risks of hysteroscopic myomectomy. There are several procedures and techniques to reduce haemorrhage during myomectomy for fibroids. Some research demonstrated excellent outcomes with uterine artery ligation.</p><p>Mioma uteri adalah tumor jinak yang paling sering dijumpai pada wanita. Tindakan miomektomi adalah salah satu pilihan terapi pada wanita yang tetap ingin mempertahankan rahim. Perdarahan, perforasi uterus, cedera serviks dan masalah metabolisme akibat penyerapan berlebihan media distensi, seperti glisin, adalah risiko prosedur histeroskopi miomektomi. Beberapa prosedur dan teknik dapat mengurangi perdarahan saat miomektomi pada kasus mioma uteri. Beberapa penelitian menunjukkan hasil yang sangat baik dengan ligasi arteri uterina.</p>
41
Ivanova, Yoana G., Muhammad Gohar, Elitsa H. Gyokova, Angel D. Yordanov, and Dobromir D. Dimitrov. "Use of High-Intensity Focused Ultrasound (HIFU) in Treating Uterine Fibroids: A Case Report." Journal of Biomedical and Clinical Research 15, no. 2 (December 1, 2022): 178–81. http://dx.doi.org/10.2478/jbcr-2022-0025.
Full textAbstract:
Summary Uterine fibroids are the most common benign uterine tumours in women of reproductive age. They can present with different symptoms, including menorrhagia, cramping lower abdominal pain, bloating, urinary/bowel symptoms, spotting, and infertility. Management could be medical and surgical. Other options include uterine artery embolization and non-invasive treatment with high-intensity focused ultrasound (HIFU). We present a case of a 32-year-old woman with menorrhagia and severe pelvic pain. Ultrasound examination revealed an intramural myoma measuring 93x98x87 mm. The patient signed informed consent for HIFU ablation of the fibroid. Three months after the procedure, an MRI scan showed the fibroid had shrunk to 75% of its original size with dimensions 32x35x29. After six months, she became pregnant and gave birth to a healthy infant at 38-weeks gestation with caesarean section, at which point the fibroid measured 2 cm. HIFU is an alternative to surgical therapies and is highly beneficial in women wishing for future pregnancies. Preserving the option for future pregnancies in patients with uterine fibroids is only one of its benefits and might be the key solution for these women. HIFU treatment of uterine fibroids is an innovative approach. It should be encouraged: it is widely adopted in similar cases where it has positively impacted the treatment of uterine fibroids.
42
Costa, Ana R., Ana P. Carvalho, Diana R. Martins, Maria J. Carvalho, Pedro T. Silva, Sílvia C. Roque, and Daniel P. Silva. "Series of 55 pregnancies following ulipristal acetate treatment of symptomatic uterine fibroids." Journal of Endometriosis and Pelvic Pain Disorders 12, no. 3-4 (July 20, 2020): 170–75. http://dx.doi.org/10.1177/2284026520932468.
Full textAbstract:
Introduction: Treatment with ulipristal acetate effectively controls excessive bleeding due to uterine fibroids and reduces their size. Uterine fibroid size reduction is expected to improve the results of the myomectomy and the reproductive prospects of the patient. Methods: Retrospective and descriptive analysis of a series of 53 patients who achieved pregnancy after being treated for symptomatic uterine fibroids. The primary endpoints were pregnancy and birth outcomes in women with symptomatic uterine fibroids that conceived following at least one course of therapy with ulipristal acetate 5 mg/day. The secondary endpoints were time until pregnancy, reasons for ulipristal acetate treatment, number of treatment courses completed, hemorrhagic control achievement, hemoglobin levels, fibroid FIGO classification, largest fibroid diameter, and type of myomectomy (if any). Results: Fifty-five pregnancies were registered in 53 patients following ulipristal acetate therapy (43 live births, 9 miscarriages, and 3 ongoing pregnancies). Half of the patients became pregnant without interval surgery. Bleeding control was achieved in 96% of the cases. A significant increase (p < 0.001) in hemoglobin levels and a reduction (p < 0.001) in uterine fibroid size was observed after treatment. No malformations were reported among newborns after ulipristal acetate therapy. Conclusion: So far, this is the largest case series reporting both pregnancy and birth outcomes following ulipristal acetate therapy for uterine fibroids. Our data support favorable outcomes after therapy for this population subset.
43
Matsushima, Hisakazu, Ken Kageyama, Akira Yamamoto, Atsushi Jogo, Etsuji Sohgawa, Takehito Nota, Kazuki Murai, et al. "Observation of Intramural Fibroid Expulsion on MRI after Uterine Artery Embolization." Case Reports in Radiology 2021 (August 14, 2021): 1–5. http://dx.doi.org/10.1155/2021/7970894.
Full textAbstract:
Uterine artery embolization (UAE) is a type of noninvasive treatment for symptomatic uterine fibroids. One of the complications of UAE is fibroid expulsion. Here, we report a case of a 45-year-old woman who underwent UAE for an intramural fibroid, which resulted in fibroid expulsion. To the best of our knowledge, there are only few reports of expulsion of intramural fibroids. The process of fibroid protrusion from the myometrium into the uterine cavity was depicted on magnetic resonance imaging (MRI) in this case. We discuss the risk factors and mechanisms of fibroid expulsion after UAE.
44
Khotanlou, Hassan, Alireza Fallahi, Mohammad Ali Oghabian, and Mohammad Pooyan. "SEGMENTATION OF UTERINE FIBROID ON MR IMAGES BASED ON CHAN–VESE LEVEL SET METHOD AND SHAPE PRIOR MODEL." Biomedical Engineering: Applications, Basis and Communications 26, no. 02 (March 12, 2014): 1450030. http://dx.doi.org/10.4015/s1016237214500306.
Full textAbstract:
Uterine fibroids are common tumors of female pelvis. Uterine artery embolization (UAE) is an effective treatment of symptomatic uterine fibroids by shrinkage of the size of these tumors. Segmentation of the fibroid region is essential for an accurate treatment strategy. Complex fibroids anatomy, nonhomogeneity region and missing boundary in some cases make this task very challenging. In this paper, we present a method to robustly segment these fibroids on magnetic resonance image (MRI). Our method is based on combination of two steps; Chan–Vese level set method and geometric shape prior model. By calculating an initial region inside the fibroid using Chan–Vese level sets method, rough segmentation can be obtained followed by a prior shape model. We found this algorithm efficient, which provides good and reliable result.
45
Zaitseva, Marina, Sarah J. Holdsworth-Carson, Luke Waldrip, Julia Nevzorova, Luciano Martelotto, Beverley J. Vollenhoven, and Peter A. W. Rogers. "Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids." REPRODUCTION 146, no. 2 (August 2013): 91–102. http://dx.doi.org/10.1530/rep-13-0087.
Full textAbstract:
Uterine fibroids are the most common benign tumour afflicting women of reproductive age. Despite the large healthcare burden caused by fibroids, there is only limited understanding of the molecular mechanisms that drive fibroid pathophysiology. Although a large number of genes are differentially expressed in fibroids compared with myometrium, it is likely that most of these differences are a consequence of the fibroid presence and are not causal. The aim of this study was to investigate the expression and regulation of NR2F2 and CTNNB1 based on their potential causal role in uterine fibroid pathophysiology. We used real-time quantitative RT-PCR, western blotting and immunohistochemistry to describe the expression of NR2F2 and CTNNB1 in matched human uterine fibroid and myometrial tissues. Primary myometrial and fibroid smooth muscle cell cultures were treated with progesterone and/or retinoic acid (RA) and sonic hedgehog (SHH) conditioned media to investigate regulatory pathways for these proteins. We showed that NR2F2 and CTNNB1 are aberrantly expressed in fibroid tissue compared with matched myometrium, with strong blood vessel-specific localisation. Although the SHH pathway was shown to be active in myometrial and fibroid primary cultures, it did not regulateNR2F2orCTNNB1mRNA expression. However, progesterone and RA combined regulatedNR2F2mRNA, but notCTNNB1, in myometrial but not fibroid primary cultures. In conclusion, we demonstrate aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids compared with normal myometrium, consistent with the hypothesis that these factors may play a causal role uterine fibroid development.
46
Li, Bo, Fangfang Wang, Lingying Chen, and Haofei Tong. "Global epidemiological characteristics of uterine fibroids." Archives of Medical Science 19, no. 6 (October 30, 2023): 1802–10. http://dx.doi.org/10.5114/aoms/171786.
Full textAbstract:
IntroductionThe aim of the study was to examine the burden of uterine fibroids at global, regional and national levels in terms of age and the Socio-demographic Index (SDI).Material and methodsData were extracted from the GBD 2019 dataset. Estimated annual percentage changes (EAPCs) were calculated to assess the incidence of uterine fibroids, and trends in disability-adjusted life years (DALYs) were examined. All measures examined were stratified by region, country, age and SDI to assess the effects of these variables on the incidence of uterine fibroids.ResultsThe global age-standardized incidence rate of uterine fibroids increased from 1990 to 2019, with an EAPC of 0.25 (95% confidence interval (CI): 0.24 to 0.27). In contrast, the global age-standardized DALY rate decreased from 1990 to 2019, with an EAPC of –0.27 (95% CI: –0.31 to –0.23). High and low-middle SDI regions experienced significantly higher age-standardized incidence rates. Moreover, in 2019, low and low-middle SDI regions had significantly higher age-standardized DALY rates due to uterine fibroids than other SDI regions. Regionally, Eastern Europe had the highest age-standardized incidence rate of uterine fibroids in 2019, and Tropical Latin America experienced the greatest increase in age-standardized incidence rates from 1990 to 2019. Nationally, Brazil (EAPC = 1.46; 95% CI: 1.35–1.57) and India (EAPC = 1.09; 95% CI: 0.94–1.25) experienced the most significant increases in age-standardized uterine fibroid incidence. Age-standardized DALY rates increased the most in Tropical Latin America, high-income North America and Oceania.ConclusionsGlobally, the age-standardized incidence of uterine fibroids has been increasing in recent years. In contrast, age-standardized DALY rates have exhibited a decreasing trend. Eastern Europe, Tropical Latin America, Brazil and India experience the greatest uterine fibroid burden. Globally, women aged 35–39 years and older have an increased risk of uterine fibroids, as reflected in the higher incidence rates among these age groups.
47
Singh, Shikha, "Kavita ", and Neha Garg. "Treatment Of Uterine Fibroid Through Complementary Medicine And Alternative Therapy Approaches: A Case Series." Migration Letters 20, S12 (December 14, 2023): 1086–96. http://dx.doi.org/10.59670/ml.v20is12.8228.
Full textAbstract:
The study aims to provide the alternative methods for the management of uterine fibroid. In this case series, we conducted a case series of 8 patients with symptomatic uterine fibroids. The patients were assigned to take Ayurvedic medicines and Intrauterine Uttarbasti with 4-5ml with Kapharbuda-har oil for 3 months. Intrauterine Uttarbasti was given for 7 days in a month, after the end of mensuration. Investigations like USG (pelvis region) and % haemoglobin, were conducted before and after the treatment. Investigations revealed a decrease in uterine fibroid size, after the treatment. In 3 patients there was about 40%-80% reduction in fibroid size. In 3 patient’s fibroids were completely cured while in 2 patients, 16-27 % of fibroid size got decreased. Concurrently, menstrual blood flow as well as other symptoms like abdominal pain associated with fibroids also got resolved, after the treatment. Based on the results, we can conclude that Ayurvedic treatments are very effective in managing the size of uterine fibroid as well as symptoms associated with uterine fibroid. Further research is required to evaluate the mechanism of drug action, effectiveness and unfavourable consequences of the treatment.
48
Pandey, Dr Surendra, and Dr Harvinder Singh. "Pharmacological Activity and Effectiveness of Electrohomoeopathy Medicine on Uterine Fibroids Individuals." International Journal of Innovative Research in Medical Science 6, no. 10 (October 2, 2021): 649–55. http://dx.doi.org/10.23958/ijirms/vol06-i10/1239.
Full textAbstract:
Electropathy/Electrohomoeopathy is a comparatively modern medical technique that falls under the genre of complementary and alternative medicine. This medical technique was discovered in Italy in 1865 by Count Ceaser Mattei. Its drugs are composed entirely of herbal/medicinal plants and are manufactured with purified water and a sophisticated process of extracting spagiric essence from medicinal plants at room temperature. Uterine fibroids are noncancerous uterine growths that commonly arise during childbearing year. Uterine fibroids, also known as leiomyomas (lie-o-my-O-muhs) or myomas, aren't linked to an increased risk of uterine cancer and almost never turn cancerous. Fibroids range in size from microscopic seedlings that are undetectable to large masses that deform and expand the uterus. A single fibroid or a group of them can be present. Multiple fibroids can cause the uterus to enlarge to the point where it reaches the rib cage, causing weight gain. Uterine fibroids affect many women at some point in their life. However, because uterine fibroids rarely cause symptoms, people may be unaware that they have them. During a pelvic exam or a pregnancy ultrasound, fibroids may be encounter by chance. By the time they reach at the age 50, 20% to 80% of women experience fibroids. Women in their age forties and early fifties are the most susceptible to develop get fibroids. In this article we are going to discussed effectiveness of Electrohomoeopathy medicine on Uterine fibroids. How a new medical science which is totally plants-based source cost effective and accelerating its mechanism of action due to specialization of its unique fundamental principal and philosophy and satisfaction of patient due to the extraordinary result of Electrohomoeopathy medicine.
49
Batool, Mussarat, Ayesha Ahmed, Sidra Rauf, Shirza Sharafat, and Shabnum Rasheed. "Prolapsed Fibroid in Pregnancy." Journal of Islamabad Medical & Dental College 12, no. 3 (October 17, 2023): 222–24. http://dx.doi.org/10.35787/jimdc.v12i3.999.
Full textAbstract:
Uterine fibroids are commonly encountered in clinical practice. Majority of the fibroids are usually asymptomatic during pregnancy, however they may lead to complications in all three trimesters of pregnancy and even in the post natal period, causing a management dilemma. Vaginal prolapse of uterine fibroids is a rare phenomenon during pregnancy, delivery or puerperium. While most of the fibroids are managed conservatively, a few require surgical intervention Despite of multiple publications in the medical literature on the gynecological aspects of fibroids, scanty data is available on management during pregnancy and labor, posing a therapeutic dilemma. We present a case of a G4P3, presenting at 30weeks gestation with large degenerated prolapsed uterine fibroid which was successfully managed by vaginal myomectomy concurrently with cesarean section.
50
karlsen, kamilla, Ulrik Schiøler Kesmodel, Ole Mogensen, Peter Humaidan, and Pernille Ravn. "Relationship between a uterine fibroid diagnosis and the risk of adverse obstetrical outcomes: a cohort study." BMJ Open 10, no. 2 (February 2020): e032104. http://dx.doi.org/10.1136/bmjopen-2019-032104.
Full textAbstract:
ObjectiveThe aim was to investigate the association between clinically significant uterine fibroids and preterm birth, caesarean section (CS), postpartum haemorrhage (PPH), placental abruption, intrauterine growth restriction (IUGR) and uterine rupture.Methods, participants and settingA historical cohort study based on data from the Danish National Birth Cohort, the Danish National Patient Registry and the Danish National Birth Registry (DNBR). The final study population consisted of 92 696 pregnancies and was divided into four groups for comparison. Group 1: pregnancies of women without a fibroid diagnosis code or fibroid operation code; group 2: pregnancies of women with a fibroid diagnosis code before pregnancy, during pregnancy or up to 1 year after delivery, and no fibroid operation code before pregnancy; group 3: pregnancies of women with a fibroid diagnosis code given more than 1 year after delivery; and group 4: pregnancies of women with a fibroid operation code given before pregnancy.ResultsA diagnosis of fibroids before pregnancy yielded an increased risk of preterm birth (gestational age (GA) ≤37 weeks) (OR 2.27 (1.30─3.96)) and extreme preterm birth (GA 22+0─27+6 weeks, OR 20.09 (8.04─50.22)). The risk of CS was increased (OR 1.83 (1.23─2.72)) for women with a fibroid diagnosis code given before pregnancy; significantly increased risk of elective CS (OR 1.92 (1.11─3.32)), but not acute CS (OR 1.54 (0.94─2.52)). The risks of PPH, placental abruption or IUGR were not increased in any of the groups.ConclusionWe found a strong association between clinically significant uterine fibroids and preterm birth, and an association between clinically significant uterine fibroids and CS. In contrast, no association between clinically significant uterine fibroids and PPH, placental abruption or IUGR was seen.