Academic literature on the topic 'Uterine leiomyosarcoma'

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Journal articles on the topic "Uterine leiomyosarcoma"

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Ajayi, Olusola Lawrence, Moshood Olajire Olaniyi, Olugbenga Olayinka Alaka, Richard Edem Antia, and Temitope Morenikeji Oladipo. "Uterine Leiomyosarcoma Associated with Cystic Endometrial Polyps, Chondriod Metaplasia and Uterine Horn Intussusception in a Greater Cane Rat (Thryonomys swinderianus)." Macedonian Veterinary Review 43, no. 2 (2020): 197–204. http://dx.doi.org/10.2478/macvetrev-2020-0019.

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AbstractA rare case of uterine leiomyosarcoma associated with chondriod metaplasia, cystic endometrial polyps and uterine horn intussusception in a greater cane rat was macroscopically, histopathologically, immuno-histochemically and ultrastructurally evaluated. The histopathological findings for this tumour were similar to those for leiomyosarcomas described in other species. Immunohistochemical examination demonstrated positive immunoreactivity of neoplastic cells with α-smooth muscle actin, desmin and vimentin. Ultrastructurally, nuclear and cytoplasmic features were consistent with leiomyo
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Sindhu, Sekar. "An Unusual Presentation of Uterine Leiomyosarcoma and Diagnostic Challenges." MAR Clinical Case Reports 4, no. 10 (2023): 8. https://doi.org/10.5281/zenodo.10012270.

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<i><strong>Abstract</strong></i><i>Uterine leiomyosarcoma (ULMS) is a rare and aggressive type of uterine cancer that is difficult to diagnose due to its nonspecific symptoms and resemblance to other gynaecological conditions. This case report describes a 66-year-old woman who was initially diagnosed with carcinosarcoma following hysteroscopic endometrial polypectomy and curettage, post-operative histology revealed stage 1B leiomyosarcoma with no metastasis. This report highlights the diagnostic challenges of distinguishing between leiomyosarcoma and carcinosarcoma and emphasises the importanc
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Peters, Ann, Amanda M. Sadecky, Daniel G. Winger, et al. "Characterization and Preoperative Risk Analysis of Leiomyosarcomas at a High-Volume Tertiary Care Center." International Journal of Gynecologic Cancer 27, no. 6 (2017): 1183–90. http://dx.doi.org/10.1097/igc.0000000000000940.

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IntroductionUterine morcellation in minimally invasive surgery has recently come under scrutiny because of inadvertent dissemination of malignant tissue, including leiomyosarcomas commonly mistaken for fibroids. Identification of preoperative risk factors is crucial to ensure that oncologic care is delivered when suspicion for malignancy is high, while offering minimally invasive hysterectomies to the remaining patients.ObjectivesThe aim of this study was to characterize risk factors for uterine leiomyosarcomas by reviewing preoperative, intraoperative, and postoperative data with an emphasis
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Hensley, Martee L., Brigitte A. Barrette, Klaus Baumann, et al. "Gynecologic Cancer InterGroup (GCIG) Consensus Review: Uterine and Ovarian Leiomyosarcomas." International Journal of Gynecologic Cancer 24, Supp 3 (2014): S61—S66. http://dx.doi.org/10.1097/igc.0000000000000261.

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ObjectivesThe Gynecologic Cancer InterGroup aimed to provide an overview of uterine and ovarian leiomyosarcoma management.MethodsPublished articles and author experience were used to draft management overview. The draft manuscript was circulated to international members of the Gynecologic Cancer InterGroup for review and comment, and appropriate revisions were made.ResultsThe approach to management of uterine and ovarian leiomyosarcoma management is reviewed.ConclusionsUterine and ovarian leiomyosarcomas are rare and aggressive cancers that require specialized expertise for optimal management.
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Irizarry-Villafañe, Gabriel, Nadyeschka Rivera-Santana, Michelle Mangual-García, et al. "A Rare Case of Uterine Leiomyosarcoma with Metastasis to the Thyroid Gland." Case Reports in Endocrinology 2020 (June 30, 2020): 1–4. http://dx.doi.org/10.1155/2020/8889843.

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Uterine leiomyosarcomas are aggressive tumors associated with a poor prognosis. These neoplasms have high metastatic potential, more frequently affecting the lungs, liver, and peritoneum. There are very few cases of metastasis to the thyroid described in the literature. We present the case of a 47-year-old female diagnosed with uterine leiomyosarcoma metastatic to the thyroid gland. In this case report, we want to emphasize the utility of ancillary studies to help differentiate a leiomyosarcoma from anaplastic thyroid carcinoma since cytologic evaluation alone can be challenging.
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Sah, Shatrughan P., and W. Glenn McCluggage. "DOG1 immunoreactivity in uterine leiomyosarcomas." Journal of Clinical Pathology 66, no. 1 (2012): 40–43. http://dx.doi.org/10.1136/jclinpath-2012-201150.

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AimsDOG1 is a recently described marker of gastrointestinal stromal tumour (GIST) which is considered to be extremely sensitive and, among mesenchymal neoplasms, quite specific for this tumour type. Following the identification of DOG1 immunoreactivity in a uterine leiomyosarcoma, we wished to ascertain how prevalent DOG1 immunoreactivity was in this tumour type.MethodsWe stained a series of uterine leiomyosarcomas (n=26) with DOG1 and with CD117 (c-kit), another marker of GIST. Staining with both markers was classified as negative, focal (&lt;50% tumour cells positive) or diffuse (≥50% tumour
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Hosseini, H., O. Vele, P. Unger, et al. "Uterine Leiomyosarcoma with a Novel RAB2A-PLAG1 Gene Fusion." American Journal of Clinical Pathology 158, Supplement_1 (2022): S88—S89. http://dx.doi.org/10.1093/ajcp/aqac126.185.

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Abstract Introduction/Objective Uterine leiomyosarcoma is a malignant neoplasm with three distinct histologic subtypes: spindle, epithelioid, and myxoid. Distinguishing leiomyosarcoma from mesenchymal uterine neoplasms such as endometrial stromal sarcoma can be challenging as they may exhibit a similar histology and immunohistochemical profile. In such cases, molecular studies can help achieve the definitive diagnosis. It has been shown that ~25% of the uterine myxoid leiomyosarcomas harbor TRPS1-PLAG1 and RAD51B-PLAG1 gene fusions. To our knowledge, no uterine leiomyosarcoma with RAB2A-PLAG1
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L. Byar, MSN, APN, BC, BMTCN, Katherine, and Tricia Fredericks, MD, MPH. "Uterine Leiomyosarcoma." Journal of the Advanced Practitioner in Oncology 13, no. 1 (2022): 70–76. http://dx.doi.org/10.6004/jadpro.2022.13.1.6.

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Leiomyosarcoma (LMS) is the most common soft tissue sarcoma in adults and can occur in any part of the body. Uterine leiomyosarcoma (uLMS) is the most common location for LMS, making up 2% to 5% of all uterine malignancies. It is an aggressive tumor that is challenging to treat because of its resistance to standard therapy. The majority of patients (60%) are diagnosed with early-stage disease. However, regardless of the stage, uLMS has a poor prognosis. Surgical resection is the cornerstone of treatment for patients with localized LMS independent of the site of origin. Adjuvant chemotherapy fo
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Juhasz-Böss, Ingolf, Lena Gabriel, Rainer M. Bohle, Lars C. Horn, Erich-Franz Solomayer, and Georg-Peter Breitbach. "Uterine Leiomyosarcoma." Oncology Research and Treatment 41, no. 11 (2018): 680–86. http://dx.doi.org/10.1159/000494299.

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Gockley, Allison A., J. Alejandro Rauh-Hain, and Marcela G. del Carmen. "Uterine Leiomyosarcoma." International Journal of Gynecological Cancer 24, no. 9 (2014): 1538–42. http://dx.doi.org/10.1097/igc.0000000000000290.

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Dissertations / Theses on the topic "Uterine leiomyosarcoma"

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Matsumura, Noriomi. "Oncogenic property of acrogranin in human uterine leiomyosarcoma : direct evidence of genetic contribution in in vivo tumorigenesis." Kyoto University, 2007. http://hdl.handle.net/2433/135712.

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Ricci, Anamaria Ritti. "FOXO3a em leiomioma e leiomiossarcoma uterinos: avaliação de seu potencial para terapia alvo in vitro." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27022019-123144/.

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Os tumores de musculatura liso do útero se desenvolvem a partir do miométrio e podem apresentar carcterísticas clínicas malignas e benignas. Dentre eles, o leiomiossarcoma (LMS) é o tumor maligno mais comum, com altas taxas de metástase e recidiva, mesmo sendo diagnosticado em estágios iniciais. Já os leiomiomas (LM) são os tumores benignos mais frequentes em mulheres em idade reprodutiva. Ambos possuem mesma diferenciação celular, porém com comportamentos clínico e biológico bastante distintos, e até o momento não se dispõe de tratamento específico ou curativo. Nesse contexto, a busca por nov
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Anjos, Laura Gonzalez dos. "Estudo da expressão de microRNAs em amostras de carcinossarcomas e sarcomas uterinos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-07032017-115512/.

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Introdução: Os sarcomas uterinos constituem uma forma rara de neoplasia maligna que compreende cerca de 3% de todos os canceres uterinos. Os fatores de risco são pouco conhecidos e as formas de tratamento escassas, sendo o papel da quimioterapia e radioterapia limitado. Nesse contexto, torna-se importante a compreensão dos mecanismos moleculares envolvidos no processo de carcinogênese, tanto para diagnóstico e prognóstico mais precisos, quanto para ampliar os avanços terapêuticos. Um dos mecanismos moleculares envolvidos no desenvolvimento de canceres é a regulação da expressão gênica por micr
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Garcia, Natalia. "Via de sinalização do Sonic Hedgehog em leiomioma e leiomiossarcoma uterinos: estudo da expressão transcricional e protéica de moléculas envolvidas na via." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12052015-105036/.

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Leiomioma (LMU) e leiomiossarcoma (LMSU) são tumores mesenquimais que se desenvolvem no útero e apresentam comportamento clínico variável. Ambos são neoplasias do miométrio (MM), com mesmo padrão de diferenciação celular, porém com progressão clínica completamente diferente. Até o momento, existe grande controvérsia quanto aos fatores relacionados ao surgimento dessas neoplasias e uma possível malignização de um leiomioma pré-existente. Foi demonstrado que a ativação da via de sinalização do Sonic hedgehog (SHH) está relacionada ao desenvolvimento de diversos tipos de tumor, uma vez que a mesm
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Almeida, Thaís Gomes de. "Análise da expressão do fator de crescimento HER-2 e do fator de transcrição FOXO3a em sarcomas e carcinossarcomas uterinos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12012016-113204/.

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Sarcomas uterinos são tumores mesodérmicos raros que compreendem, aproximadamente, 3% de todos os cânceres uterinos. Até o momento não há consenso quanto os fatores de risco para determinar um pior prognóstico e tratamento mais adequado. A radioterapia adjuvante não tem impacto na sobrevida e o papel da quimioterapia ainda é limitado. Nesse contexto, a busca por marcadores moleculares mostra-se importante tanto para a individualização do tratamento, quanto para o diagnóstico e prognóstico desses tumores. O objetivo deste estudo foi avaliar a expressão de HER-2 e do fator de transcrição FOXO3a
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Books on the topic "Uterine leiomyosarcoma"

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Carton, James. Gynaecological pathology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198759584.003.0012.

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This chapter covers gynaecological pathology and includes vulval skin diseases, benign vulval tumours, vulval carcinoma, vaginal infections, vaginal tumours, cervical carcinoma, cervical screening, endometriosis, endometrial carcinoma, uterine leiomyomas (fibroids), uterine leiomyosarcoma, functional ovarian cysts, benign non-epithelial ovarian tumours, benign epithelial ovarian tumours, borderline epithelial ovarian tumours, ovarian carcinomas, pelvic inflammatory disease, ectopic pregnancy, polycystic ovarian syndrome, hydatidiform mole, and pre-eclampsia.
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Book chapters on the topic "Uterine leiomyosarcoma"

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Mocellin, Simone. "Uterine Leiomyosarcoma." In Soft Tissue Tumors. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-58710-9_250.

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del Carmen, Marcela G. "Uterine Leiomyosarcoma." In Uncommon Gynecologic Cancers. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118655344.ch15.

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Kotani, Yasushi, and Noriomi Matsumura. "Differential Diagnosis of Uterine Leiomyosarcoma and Uterine Sarcoma (Leiomyosarcoma, Endometrial Stromal Sarcoma)." In MRI and CT for Decision-Making in Obstetrics and Gynecology Practice. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-5120-4_23.

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Banjar, Mai Adnan, Louise Elizabeth Pearce, Yingting Mok, Jason Yong Sheng Chan, and James Thomas Patrick Decourcy Hallinan. "Smooth Muscle Tumours: Leiomyosarcoma (Non-uterine)." In Clinical Management of Bone and Soft Tissue Tumors. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-96-2163-7_21.

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Low, Jeffrey Jen Hui, Jeslyn Wong, Diana Gkeok Stzuan Lim, et al. "Uterine Sarcomas (Leiomyosarcoma, Endometrial Stromal Sarcoma and Adenosarcoma)." In Clinical Management of Bone and Soft Tissue Tumors. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-96-2163-7_26.

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Nitecki, Roni, and J. Alejandro Rauh-Hain. "Uterine Leiomyosarcoma." In Uterine Fibroids. CRC Press, 2020. http://dx.doi.org/10.1201/9780429155734-23.

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Hinchcliff, Emily, Barrett Lawson, Ravin Ratan, and Pamela Soliman. "Uterine leiomyosarcoma." In Diagnosis and Treatment of Rare Gynecologic Cancers. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-82938-0.00009-4.

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Pritts, Elizabeth A. "Leiomyosarcoma." In Modern Management of Uterine Fibroids. Cambridge University Press, 2020. http://dx.doi.org/10.1017/9781108332798.017.

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Rekha, Upadhya, Vidyashree G. Poojari, Muralidhar V. Pai, and Jayaraman Nambiar. "A Rare Uterine Cancer: Epithelioid Leiomyosarcoma." In New Frontiers in Medicine and Medical Research Vol. 16. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/nfmmr/v16/1906c.

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Shakeel, Hoosdally. "Computational Methods for Personalized Targeted Therapy in Uterine Leiomyosacoma." In Gynecological Cancers - New Perspectives and Applications in Their Treatment [Working Title]. IntechOpen, 2024. https://doi.org/10.5772/intechopen.1007909.

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Uterine leiomyosarcoma (ULMS) is an uncommon gynecological cancer, and treatments such as surgical debulking, chemotherapy, and radiotherapy have had limited results. This investigation study is about a scenario of a 53- year-old woman, whereby conventional protocol through combining doxetatacel, gemcitabine, pazopanib, pemetrexed, and doxorubicin with surgery and radiation did not avoid metastasis, resulting in the death of the patient. A strategy of personalized tumor therapy was used. Through the recommendation of a ctdna (circulating tumor DNA) next-generation sequencing (NGS) using blood
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Conference papers on the topic "Uterine leiomyosarcoma"

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Garg, Poonam. "Leiomyosarcoma: Case report." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685339.

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Introduction: Uterine sarcomas are rare aggressive mesenchymal tumours with limited prognosis which accounts for only 2%-8% of all uterine malignancies. The most frequent type in uterine sarcomas is leiomyosarcoma (LMS) which is seen in about 60% of cases. Case Report: We report 2 cases who presentated with different symptomology. After examination and imaging modalities, definitive diagnosis was made after histopathology report. Treatment in the form of neo adjuvant chemotherapy followed by Surgery and chemotherapy/radiotherapy was given. On follow up, both patients had relapse and later they
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Seo, Yumi, Wooyoung Kim, and E. Sun Paik. "Leiomyosarcoma: a commonly misdiagnosed uterine tumor." In The 39th Annual Meeting of the Korean Society of Gynecologic Oncology. Korean Society of Gynecologic Oncology, 2024. http://dx.doi.org/10.3802/jgo.2024.35.s2.p86.

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Ng, Chun Wai, and Kwong-Kwok Wong. "Abstract 2963: A novel uterine leiomyosarcoma mouse model." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2963.

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Khafagy, Rana T. M., Mohanad Ghonim, Mohamed Ghonim, and Karim A. Abd El Tawab. "An Unexpected Giant Uterine Fibroid Mimic: Post-uterine Artery Embolization Diagnosis of Leiomyosarcoma." In PAIRS 2024 Annual Congress. Thieme Medical and Scientific Publishers Pvt. Ltd., 2024. http://dx.doi.org/10.1055/s-0044-1785934.

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Xu, Tian-Min, Kun Zhang, Man-Hua Cui, Shu-Ying Wu, Yang Liu, and Wei-Qin Chang. "The Research on Diagnosis and Treatment of Uterine Leiomyosarcoma." In 2015 International Conference on Medicine and Biopharmaceutical. WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789814719810_0066.

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Mizuta, C., S. Nakagawa, K. Hiramatsu, et al. "379 Downregulating KIF4A significantly suppressed growth of uterine leiomyosarcoma." In ESGO 2021 Congress. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/ijgc-2021-esgo.263.

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Dall, Genevieve, Cassandra Vandenberg, Amandine Carmagnac, et al. "Abstract PO021: Developing pre-clinical models of uterine leiomyosarcoma." In Abstracts: AACR Virtual Special Conference: Endometrial Cancer: New Biology Driving Research and Treatment; November 9-10, 2020. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1557-3265.endomet20-po021.

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Almeida, Bruna Cristine De, Natalia Garcia, Edmund Chada Baracat, and Kátia Candido Carvalho. "Abstract A15: Oncomirs expression profiling in uterine leiomyosarcoma cells." In Abstracts: AACR International Conference held in cooperation with the Latin American Cooperative Oncology Group (LACOG) on Translational Cancer Medicine; May 4-6, 2017; São Paulo, Brazil. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1557-3265.tcm17-a15.

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Baghdasaryan, N., K. Quinn, and M. H. Garabedian. "Uterine Leiomyosarcoma Presenting as Hemoptysis Secondary to Pulmonary Metastases." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4174.

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Lee, EJ, HS Kim, GW Yim, JW Kim, and NH Park. "EP558 Favorable factors of surgical resection for recurrent uterine leiomyosarcoma." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.615.

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