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Journal articles on the topic 'Utilization cascades'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Xie, Guo Wei, Peng Li, and Hui Dong. "Method and Technique of Grade Recovery and Cascade Utilization (GRUC) Based on Sintering and Cooling Integration." Applied Mechanics and Materials 268-270 (December 2012): 1011–15. http://dx.doi.org/10.4028/www.scientific.net/amm.268-270.1011.

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The key problems and causes of recovery and Utilization of sintering waste heat were analyzed firstly, on the basis of sintering and cooling integration , the method and technique of grade recovery and cascade utilization (GRUC) was put forward according to the first and second laws of thermodynamics. The waste heat was recovered in grades according to the quality firstly, and then different qualities of residual heat recovered were utilized in cascades. The higher temperature part of sinter cooling waste gas was used for power recovery, the medium temperature part was used for direct thermal

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Doskolovich, Leonid L., Daniil V. Soshnikov, Georgy A. Motz, et al. "Design of Cascaded DOEs for Focusing Different Wavelengths to Different Points." Photonics 11, no. 9 (2024): 791. http://dx.doi.org/10.3390/photonics11090791.

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We propose a task-specific method for calculating cascaded phase diffractive optical elements (DOEs) for focusing Q incident beams with different wavelengths to Q given points. Due to the utilization of a special optimization criterion, the proposed method makes it possible to calculate the elements of the cascaded DOE in a sequential way. In addition, the calculation of the diffractive microrelief of each DOE in the cascade is reduced to solving a set of independent and computationally simple “pointwise” optimization problems. Using the proposed method, cascades of two DOEs were designed to f

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3

Kim, David D., Allan T. Daly, Benjamin C. Koethe, et al. "Low-Value Prostate-Specific Antigen Test for Prostate Cancer Screening and Subsequent Health Care Utilization and Spending." JAMA Network Open 5, no. 11 (2022): e2243449. http://dx.doi.org/10.1001/jamanetworkopen.2022.43449.

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ImportanceDelivering low-value care can lead to unnecessary follow-up services and associated costs, and such care cascades have not been well examined in common clinical scenarios.ObjectiveTo evaluate the utilization and costs of care cascades of prostate-specific antigen (PSA) tests for prostate cancer screening, as the routine use of which among asymptomatic men aged 70 years and older is discouraged by multiple guidelines.Design, Setting, and ParticipantsThis cross-sectional study included men aged 70 years and older without preexisting prostate conditions enrolled in a Medicare Advantage

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Turcotte, Lorraine P., and Marcia J. Abbott. "Contraction-induced signaling: evidence of convergent cascades in the regulation of muscle fatty acid metabolism." Canadian Journal of Physiology and Pharmacology 90, no. 11 (2012): 1419–33. http://dx.doi.org/10.1139/y2012-124.

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The regulation of fatty acid utilization during muscle contraction and exercise remains to be fully elucidated. Evidence suggests that the metabolic responses of skeletal muscle induced by the contraction-induced changes in energy demand are mediated by the activation of a multitude of intracellular signaling cascades. This review addresses the roles played by 3 intracellular signaling cascades of interest in the regulation of fatty acid uptake and oxidation in contracting skeletal muscle; namely, the AMP-activated protein kinase (AMPK), calcium/calmodulin-dependent protein kinases (CaMKs), an

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Kirby, Amy E., Natalie D. King, and Terry D. Connell. "RhuR, an Extracytoplasmic Function Sigma Factor Activator, Is Essential for Heme-Dependent Expression of the Outer Membrane Heme and Hemoprotein Receptor of Bordetella avium." Infection and Immunity 72, no. 2 (2004): 896–907. http://dx.doi.org/10.1128/iai.72.2.896-907.2004.

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ABSTRACT Genes involved in iron (Fe) acquisition often are regulated in response to the local availability of Fe. In many bacteria, Fe-dependent responsiveness is mediated by Fur, a global Fe-dependent transcriptional repressor. Tighter regulatory control of Fur-responsive genes is afforded by incorporating additional regulators into Fur-dependent regulatory cascades. RhuI, a Fur-dependent extracytoplasmic function sigma factor of Bordetella avium, in response to the dual stimulation of Fe starvation and the presence of heme (or hemoproteins), regulates P bhuR , a heme-responsive promoter whic

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Löwe, Jana, and Harald Gröger. "Fatty Acid Hydratases: Versatile Catalysts to Access Hydroxy Fatty Acids in Efficient Syntheses of Industrial Interest." Catalysts 10, no. 3 (2020): 287. http://dx.doi.org/10.3390/catal10030287.

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The utilization of hydroxy fatty acids has gained more and more attention due to its applicability in many industrial building blocks that require it, for example, polymers or fragrances. Furthermore, hydroxy fatty acids are accessible from biorenewables, thus contributing to a more sustainable raw material basis for industrial chemicals. Therefore, a range of investigations were done on fatty acid hydratases (FAHs), since these enzymes catalyze the addition of water to an unsaturated fatty acid, thus providing an elegant route towards hydroxy-substituted fatty acids. Besides the discovery and

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Altieri, Andrew H., and Andrew D. Irving. "Species coexistence and the superior ability of an invasive species to exploit a facilitation cascade habitat." PeerJ 5 (February 21, 2017): e2848. http://dx.doi.org/10.7717/peerj.2848.

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Facilitation cascades generated by co-occurring foundation species can enhance the abundance and diversity of associated organisms. However, it remains poorly understood how differences among native and invasive species in their ability to exploit these positive interactions contribute to emergent patterns of community structure and biotic acceptance. On intertidal shorelines in New England, we examined the patterns of coexistence between the native mud crabs and the invasive Asian shore crab in and out of a facilitation cascade habitat generated by mid intertidal cordgrass and ribbed mussels.

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Höglmeier, Karin, Gabriele Weber-Blaschke, and Klaus Richter. "Utilization of recovered wood in cascades versus utilization of primary wood—a comparison with life cycle assessment using system expansion." International Journal of Life Cycle Assessment 19, no. 10 (2014): 1755–66. http://dx.doi.org/10.1007/s11367-014-0774-6.

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9

Sokic-Lazic, Daria, Adalgisa Rodrigues de Andrade, and Shelley D. Minteer. "Utilization of enzyme cascades for complete oxidation of lactate in an enzymatic biofuel cell." Electrochimica Acta 56, no. 28 (2011): 10772–75. http://dx.doi.org/10.1016/j.electacta.2011.01.050.

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10

DuShane, Jeanne K., and Melissa S. Maginnis. "Human DNA Virus Exploitation of the MAPK-ERK Cascade." International Journal of Molecular Sciences 20, no. 14 (2019): 3427. http://dx.doi.org/10.3390/ijms20143427.

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The extracellular signal-regulated kinases (ERKs) comprise a particular branch of the mitogen-activated protein kinase cascades (MAPK) that transmits extracellular signals into the intracellular environment to trigger cellular growth responses. Similar to other MAPK cascades, the MAPK-ERK pathway signals through three core kinases—Raf, MAPK/ERK kinase (MEK), and ERK—which drive the signaling mechanisms responsible for the induction of cellular responses from extracellular stimuli including differentiation, proliferation, and cellular survival. However, pathogens like DNA viruses alter MAPK-ERK

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Faqihi, Fahimeh, Marcus A. Stoodley, and Lucinda S. McRobb. "The Evolution of Safe and Effective Coaguligands for Vascular Targeting and Precision Thrombosis of Solid Tumors and Vascular Malformations." Biomedicines 9, no. 7 (2021): 776. http://dx.doi.org/10.3390/biomedicines9070776.

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In cardiovascular and cerebrovascular biology, control of thrombosis and the coagulation cascade in ischemic stroke, myocardial infarction, and other coagulopathies is the focus of significant research around the world. Ischemic stroke remains one of the largest causes of death and disability in developed countries. Preventing thrombosis and protecting vessel patency is the primary goal. However, utilization of the body’s natural coagulation cascades as an approach for targeted destruction of abnormal, disease-associated vessels and tissues has been increasing over the last 30 years. This vasc

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Hepperle, Frieder, Teuffel Konstantin von, and Frank Brodbeck. "Rural development towards a bio-based economy – the contribution of Forest Research." Folia Forestalia, Series A - Forestry 51(1) (March 1, 2009): 49–53. https://doi.org/10.5281/zenodo.30735.

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The bio-economy, using biomass from various sources and in a wide range of sectors, has reached a significant scale in Europe. The current and the potential importance of the bio-economy is illustrated with data from Germany. While the potential uses of biomass are manifold, its availability is limited. This paper discusses the resulting competition for biomass and shows possibilities to increase the biomass-potential. To satisfy the increasing demand for biomass, further research in the forestry sector is needed.

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Darmawan, I. Dewa Made Bayu Atmaja. "Implementation of Face Recognition for Attendance Recording in Online Learning." Jurnal Ilmu Komputer 16, no. 2 (2023): 7. http://dx.doi.org/10.24843/jik.2023.v16.i02.p06.

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The utilization of facial recognition technology has become increasingly imperative within the realm of online learning. The current study introduces a novel system that utilizes face recognition technology to record attendance in online learning environments. The attendance system necessitates students to activate an attendance button, whereby their attendance is subsequently documented through facial recognition technology. The system recognizes students as present solely based on facial recognition. The system stores the duration of online learning activities in a database. Implementing mac

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Morselli, Eugenia, Roberta de Souza Santos, Su Gao та ін. "Impact of estrogens and estrogen receptor-α in brain lipid metabolism". American Journal of Physiology-Endocrinology and Metabolism 315, № 1 (2018): E7—E14. http://dx.doi.org/10.1152/ajpendo.00473.2017.

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Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes increased food intake and induces the expansion of adipose tissues, for which much is known. An area of estrogenic research that has received less attention is the role of estrogens and their receptors in influencing intermediary lipid metabolism in organs such as the brain. In this review, we highlight the actions of estrogens and their receptors in regulating their impact on modulating fatty acid content, utilization, and oxidation

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Jonas, Brian A., Natalia Varlakhanova, Fumihiko Hayakawa, Michael Goodson, and Martin L. Privalsky. "Response of SMRT (Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor) and N-CoR (Nuclear Receptor Corepressor) Corepressors to Mitogen-Activated Protein Kinase Kinase Kinase Cascades Is Determined by Alternative mRNA Splicing." Molecular Endocrinology 21, no. 8 (2007): 1924–39. http://dx.doi.org/10.1210/me.2007-0035.

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Abstract The SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors are important mediators of transcriptional repression by nuclear hormone receptors. SMRT is regulated by MAPK kinase kinase (MAPKKK) cascades that induce its release from its receptor partners, its export from nucleus to cytoplasm, and derepression of target gene expression. Intriguingly, the otherwise closely related N-CoR is refractory to MAPKKK signaling under the same conditions. However, both SMRT and N-CoR are expressed as a series of alternatively sp

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Huang, Tzu-Lun, Jia-Kang Wang, Pei-Yao Chang, et al. "Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives." International Journal of Molecular Sciences 23, no. 14 (2022): 7908. http://dx.doi.org/10.3390/ijms23147908.

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Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system characterized by relapses and autoimmunity caused by antibodies against the astrocyte water channel protein aquaporin-4. Over the past decade, there have been significant advances in the biologic knowledge of NMOSD, which resulted in the IDENTIFICATION of variable disease phenotypes, biomarkers, and complex inflammatory cascades involved in disease pathogenesis. Ongoing clinical trials are looking at new treatments targeting NMOSD relapses. This review aims to provide an update on recent stu

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Hegedüs, Imre, Kitti Andreidesz, József L. Szentpéteri, et al. "The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc." International Journal of Molecular Sciences 23, no. 19 (2022): 11165. http://dx.doi.org/10.3390/ijms231911165.

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Nutritional interventions may highly contribute to the maintenance or restoration of human health. Grapes (Vitis vinifera) are one of the oldest known beneficial nutritional components of the human diet. Their high polyphenol content has been proven to enhance human health beyond doubt in statistics-based public health studies, especially in the prevention of cardiovascular disease and cancer. The current review concentrates on presenting and classifying polyphenol bioactive molecules (resveratrol, quercetin, catechin/epicatechin, etc.) available in high quantities in Vitis vinifera grapes or

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Feraldi, Alessandro, Virginia Zarulli, Kent Buse, Sarah Hawkes, and Angela Y. Chang. "Sex-disaggregated data along the gendered health pathways: A review and analysis of global data on hypertension, diabetes, HIV, and AIDS." PLOS Medicine 22, no. 5 (2025): e1004592. https://doi.org/10.1371/journal.pmed.1004592.

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Background Health data disaggregated by sex is vital for identifying the distribution of illness, and assessing risk exposures, service access, and utilization. Disaggregating data along a health pathway, i.e., the measurable continuum from risk factor exposure to final health outcome (death), and including disease prevalence and a three-step care cascade (diagnosis, treatment, and control), has the potential to provide a holistic and systematic source of information on sex- and gender-based health inequities and identify opportunities for more tailored interventions to reduce those inequities

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19

Jain, Naini, and Neha Makkar. "A Comparative Study on Water Management Practices in India with Special Reference to Gujarat and Meghalaya." Ushus - Journal of Business Management 18, no. 4 (2019): 9–21. http://dx.doi.org/10.12725/ujbm.49.2.

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India is experiencing the most terrible water emergency in its history and a large number of lives are under risk. The fast development of populace joined with rising degrees of utilization and contamination has expanded water frailty in India. Meghalaya, concealed in the slopes of eastern sub-Himalayas is one of the most excellent states in the nation. Nature has favoured her with plenteous precipitation, sun-sparkle, virgin timberlands, high levels, tumbling cascades, completely clear waterways, wandering streamlets or more all with strong, shrewd and accommodating individuals. Yet Meghalaya

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20

Zhong, Bangyu, Wen Zhang, Liangshan Ming, et al. "Innovative Application of Medicinal Insects: Employing UHPLC-MS, Bioinformatics, In Silico Studies and In Vitro Experiments to Elucidate the Multi-Target Hemostatic Mechanism of Glenea cantor (Coleoptera: Cerambycidae) Charcoal-Based Medicine." Pharmaceuticals 18, no. 4 (2025): 479. https://doi.org/10.3390/ph18040479.

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Background: Longhorn beetles, a widely recognized group of Chinese traditional medicinal insects, are characterized by their notable hemostatic properties. However, the comprehensive understanding of their medicinal potential has been hindered by the limitations of current research methodologies. Methods: This study focuses on the species Glenea cantor (Fabricius), which can produce several generations per year, and introduces a novel method using microwave carbonization techniques. By employing an in vitro coagulation test, UHPLC-MS, network pharmacology, molecular docking, and molecular dyna

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21

Frank, Roman G., Christian Wacker, and Reinhard Niehuis. "Loss Characterization of a Conventional Variable Inlet Guide Vane." International Journal of Turbomachinery, Propulsion and Power 6, no. 3 (2021): 30. http://dx.doi.org/10.3390/ijtpp6030030.

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Variable inlet guide vanes (VIGVs) are most commonly used as the major control unit of integrally geared centrifugal compressors (IGCCs). In order to enhance the efficient operating range of the compressor, the loss mechanisms and utilization limits of state-of-the-art VIGVs need to be better understood. Field measurements in the wake of a typical, commercially used configuration were therefore conducted at the VIGV test facility of the Bundeswehr University Munich. The investigations were carried out at application oriented subsonic flow conditions and stagger angles from 50∘ to 90∘ covering

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Mikkola, Satu. "Nucleotide Sugars in Chemistry and Biology." Molecules 25, no. 23 (2020): 5755. http://dx.doi.org/10.3390/molecules25235755.

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Nucleotide sugars have essential roles in every living creature. They are the building blocks of the biosynthesis of carbohydrates and their conjugates. They are involved in processes that are targets for drug development, and their analogs are potential inhibitors of these processes. Drug development requires efficient methods for the synthesis of oligosaccharides and nucleotide sugar building blocks as well as of modified structures as potential inhibitors. It requires also understanding the details of biological and chemical processes as well as the reactivity and reactions under different

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23

Sarkar, Deepranjan, Amitava Rakshit, Ahmad I. Al-Turki, R. Z. Sayyed, and Rahul Datta. "Connecting Bio-Priming Approach with Integrated Nutrient Management for Improved Nutrient Use Efficiency in Crop Species." Agriculture 11, no. 4 (2021): 372. http://dx.doi.org/10.3390/agriculture11040372.

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The increasing demand for qualitative and varietal foods by the consumer society is a big concern for energy production, and utilization of that energy in a judicious manner for sustainable management of resources is a big challenge in the eminent future. Existing resources (land, water, fertilizer, etc.) and their socioeconomic aspects warrant the farming community to adopt alternative strategies aimed at enhancing the use efficiency of inputs and improve the environmental quality. The adaptability of microbes to thrive in different environments has prompted scientists to introduce microbial

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Luo, John Zeqi, and Luguang Luo. "Ginseng on Hyperglycemia: Effects and Mechanisms." Evidence-Based Complementary and Alternative Medicine 6, no. 4 (2009): 423–27. http://dx.doi.org/10.1093/ecam/nem178.

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It has been reported that American ginseng attenuates hyperglycemia and may present itself as a supplement to diabetes therapy. However, the lack of standardization in the usage of ginseng root leads to inconclusive results when applied to diabetes treatment. The mechanisms of American ginseng root in the treatment of diabetes remains a mystery. This greatly limits the effective utilization of American ginseng in facilitating diabetic therapy. Initiating studies have shown that American ginseng increases insulin production and reduces cell death in pancreatic β-cells. Also, studies have reveal

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McMahon, S. B., and J. G. Monroe. "A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes." Molecular and Cellular Biology 15, no. 2 (1995): 1086–93. http://dx.doi.org/10.1128/mcb.15.2.1086.

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Induction of the primary response gene egr-1 occurs rapidly following antigen receptor cross-linking in B lymphocytes. Antisense studies have demonstrated that this induction is necessary for their subsequent activation to this signal. The present study examines the molecular mechanism whereby the receptor-generated signals interact with the egr-1 promoter to elicit transcription. Deletion mapping and point mutations have indicated that two of the five serum response elements (SREs) in the egr-1 promoter can mediate induction. Of the two critical SREs, both are capable of mediating maximal ind

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Sarna, Sushil K. "Neuronal locus and cellular signaling for stimulation of ileal giant migrating and phasic contractions." American Journal of Physiology-Gastrointestinal and Liver Physiology 284, no. 5 (2003): G789—G797. http://dx.doi.org/10.1152/ajpgi.00451.2001.

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We investigated the neuronal locus, the role of PKC activation, and utilization of extracellular Ca2+ and intracellular Ca2+ release in smooth muscle cells for the generation of giant migrating contractions (GMCs) and rhythmic phasic contractions (RPCs) in intact normal and inflamed canine ileum. Calcitonin gene-related peptide (CGRP), administered close intra-arterially, stimulated GMCs at higher doses and RPCs at smaller doses. These effects were blocked by prior close intra-arterial infusions of CGRP8–37, atropine, hexamethonium, and TTX but not by tachykinin, serotonin, and histaminergic r

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Klawitter, Felix, Johannes Ehler, Rika Bajorat, and Robert Patejdl. "Mitochondrial Dysfunction in Intensive Care Unit-Acquired Weakness and Critical Illness Myopathy: A Narrative Review." International Journal of Molecular Sciences 24, no. 6 (2023): 5516. http://dx.doi.org/10.3390/ijms24065516.

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Mitochondria are key structures providing most of the energy needed to maintain homeostasis. They are the main source of adenosine triphosphate (ATP), participate in glucose, lipid and amino acid metabolism, store calcium and are integral components in various intracellular signaling cascades. However, due to their crucial role in cellular integrity, mitochondrial damage and dysregulation in the context of critical illness can severely impair organ function, leading to energetic crisis and organ failure. Skeletal muscle tissue is rich in mitochondria and, therefore, particularly vulnerable to

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Salem, Mohamed, P. Brett Kenney, Caird E. Rexroad, and Jianbo Yao. "Microarray gene expression analysis in atrophying rainbow trout muscle: a unique nonmammalian muscle degradation model." Physiological Genomics 28, no. 1 (2006): 33–45. http://dx.doi.org/10.1152/physiolgenomics.00114.2006.

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Muscle atrophy is a physiological response to diverse physiological and pathological conditions that trigger muscle deterioration through specific cellular mechanisms. Despite different signals, the biochemical changes in atrophying muscle share many common cascades. Muscle deterioration as a physiological response to the energetic demands of fish vitellogenesis represents a unique model for studying the mechanisms of muscle degradation in non-mammalian animals. A salmonid microarray, containing 16,006 cDNAs, was used to study the transcriptome response to atrophy of fast-switch muscles from g

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Liu, Zhendong, Senbiao Shu, Simin Li, et al. "Anthocyanin of Black Highland Barley Alleviates H2O2-Induced Cardiomyocyte Injury and Myocardial Infarction via Activating the Phosphatase and Tensin Homolog/Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway." Foods 13, no. 9 (2024): 1417. http://dx.doi.org/10.3390/foods13091417.

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Cardiovascular disease (CVD) represents a substantial global health challenge, with its impact on mortality and morbidity rates surpassing that of cancer. The present study was designed to explore the cardioprotective properties of anthocyanin (ACN), a compound derived from black barley, against oxidative stress-induced damage in myocardial cells and to uncover the molecular mechanisms at play. Utilizing both in vitro and in vivo experimental models, our findings indicate that ACN notably reduced cell damage caused by oxidative stress and effectively prevented apoptosis. High-throughput RNA se

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Zhao, Yue, and Jiancheng Xu. "An Improved Micro-Expression Recognition Method Based on Necessary Morphological Patches." Symmetry 11, no. 4 (2019): 497. http://dx.doi.org/10.3390/sym11040497.

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Micro-expression is a spontaneous emotional representation that is not controlled by logic. A micro-expression is both transitory (short duration) and subtle (small intensity), so it is difficult to detect in people. Micro-expression detection is widely used in the fields of psychological analysis, criminal justice and human-computer interaction. Additionally, like traditional facial expressions, micro-expressions also have local muscle movement. Psychologists have shown micro-expressions have necessary morphological patches (NMPs), which are triggered by emotion. Furthermore, the objective of

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Wang, Zhixin, Yingzhi He, and Zhen Tan. "Transcription Analysis of Liver and Muscle Tissues from Landrace Finishing Pigs with Different Feed Conversion Ratios." Genes 13, no. 11 (2022): 2067. http://dx.doi.org/10.3390/genes13112067.

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The efficiency of feed utilization determines the cost and economic benefits of pig production. In the present study, two pairs of full-sibling and two pairs of half-sibling female Landrace finishing pigs were selected, with each pair including individuals with different feed conversion rates, with liver and longissimus muscle tissue samples collected from each group for transcriptome analysis. A total of 561 differentially expressed genes (DEGs), among which 224 were up-regulated and 337 were down-regulated, were detected in the liver transcriptomes in the high-feed efficiency group compared

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AlAshqar, Abdelrahman, Lauren Reschke, Gregory W. Kirschen, and Mostafa A. Borahay. "Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†." Biology of Reproduction 105, no. 1 (2021): 7–31. http://dx.doi.org/10.1093/biolre/ioab054.

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Abstract Emerging evidence supports the notion that inflammation fosters the development of common benign gynecologic disorders, including uterine leiomyoma, endometriosis, and adenomyosis. Numerous cytokines, chemokines, and growth and transcription factors have indisputable roles in the establishment and maintenance of benign gynecologic disorders by initiating complex cascades that promote proliferation, angiogenesis, and lesion progression. The interaction between inflammation and benign gynecologic disorders is orchestrated by a plethora of factors, including sex steroids, genetics, epige

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Harpaz, Dorin, Raymond C. S. Seet, Robert S. Marks, and Alfred I. Y. Tok. "B-Type Natriuretic Peptide as a Significant Brain Biomarker for Stroke Triaging Using a Bedside Point-of-Care Monitoring Biosensor." Biosensors 10, no. 9 (2020): 107. http://dx.doi.org/10.3390/bios10090107.

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Stroke is a widespread condition that causes 7 million deaths globally. Survivors suffer from a range of disabilities that affect their everyday life. It is a complex condition and there is a need to monitor the different signals that are associated with it. Stroke patients need to be rapidly diagnosed in the emergency department in order to allow the admission of the time-limited treatment of tissue plasminogen activator (tPA). Stroke diagnostics show the use of sophisticated technologies; however, they still contain limitations. The hidden information and technological advancements behind th

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Horvatić, Anita, Andrea Gelemanović, Boris Pirkić, et al. "Multi-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation." International Journal of Molecular Sciences 22, no. 21 (2021): 11678. http://dx.doi.org/10.3390/ijms222111678.

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Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approaches. To identify molecular networks and pathways which may play important roles in intervertebral disc herniation, as well as to reveal the potential features which could be useful for monitoring disease progression and prognosis, multi-omics profiling, including high-resolution liquid chromatography-

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Awasthi, Mayanka, Kumari Sushmita, Manish Singh Kaushik, Peeyush Ranjan, and Suneel Kateriya. "Novel Modular Rhodopsins from Green Algae Hold Great Potential for Cellular Optogenetic Modulation Across the Biological Model Systems." Life 10, no. 11 (2020): 259. http://dx.doi.org/10.3390/life10110259.

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Light-gated ion channel and ion pump rhodopsins are widely used as optogenetic tools and these can control the electrically excitable cells as (1) they are a single-component system i.e., their light sensing and ion-conducting functions are encoded by the 7-transmembrane domains and, (2) they show fast kinetics with small dark-thermal recovery time. In cellular signaling, a signal receptor, modulator, and the effector components are involved in attaining synchronous regulation of signaling. Optical modulation of the multicomponent network requires either receptor to effector encoded in a singl

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Grundberg, Elin, Helena Brändström, Kevin C. L. Lam, et al. "Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells." Physiological Genomics 33, no. 3 (2008): 301–11. http://dx.doi.org/10.1152/physiolgenomics.00028.2008.

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Osteoblasts are key players in bone remodeling. The accessibility of human primary osteoblast-like cells (HObs) from bone explants makes them a lucrative model for studying molecular physiology of bone turnover, for discovering novel anabolic therapeutics, and for mesenchymal cell biology in general. Relatively little is known about resting and dynamic expression profiles of HObs, and to date no studies have been conducted to systematically assess the osteoblast transcriptome. The aim of this study was to characterize HObs and investigate signaling cascades and gene networks with genomewide ex

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Bergsneider, Marvin, David A. Hovda, Ehud Shalmon, et al. "Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study." Journal of Neurosurgery 86, no. 2 (1997): 241–51. http://dx.doi.org/10.3171/jns.1997.86.2.0241.

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✓ Experimental traumatic brain injury studies have shown that cerebral hyperglycolysis is a pathophysiological response to injury-induced ionic and neurochemical cascades. This finding has important implications regarding cellular viability, vulnerability to secondary insults, and the functional capability of affected regions. Prior to this study, posttraumatic hyperglycolysis had not been detected in humans. The characteristics and incidence of cerebral hyperglycolysis were determined in 28 severely head injured patients using [18F]fluorodeoxyglucose—positron emission tomography (FDG-PET). Th

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Vakakis, Alexander F. "Passive nonlinear targeted energy transfer." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 376, no. 2127 (2018): 20170132. http://dx.doi.org/10.1098/rsta.2017.0132.

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Nonlinearity in dynamics and acoustics may be viewed as scattering of energy across frequencies/wavenumbers. This is in contrast with linear systems when no such scattering exists. Motivated by irreversible large-to-small-scale energy transfers in turbulent flows, passive targeted energy transfers (TET) in mechanical and structural systems incorporating intentional strong nonlinearities are considered. Transient or permanent resonance captures are basic mechanisms for inducing TET in such systems, as well as nonlinear energy scattering across scales caused by strongly nonlinear resonance inter

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Harmon, Mark E., and Barbara Marks. "Effects of silvicultural practices on carbon stores in Douglas-fir western hemlock forests in the Pacific Northwest, U.S.A.: results from a simulation model." Canadian Journal of Forest Research 32, no. 5 (2002): 863–77. http://dx.doi.org/10.1139/x01-216.

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We used a new model, STANDCARB, to examine effects of various treatments on carbon (C) pools in the Pacific Northwest forest sector. Simulation experiments, with five replicates of each treatment, were used to investigate the effects of initial conditions, tree establishment rates, rotation length, tree utilization level, and slash burning on ecosystem and forest products C stores. The forest examined was typical of the Cascades of Oregon and dominated by Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) and western hemlock (Tsuga heterophylla (Raf.) Sarg). Simulations were run until a C stea

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Chen, Yang, Yong Zhao, and Jing Rui Zhang. "Analysis on Electricity Pricing Mechanism for Cascade Hydropower Stations in China." Applied Mechanics and Materials 94-96 (September 2011): 2200–2203. http://dx.doi.org/10.4028/www.scientific.net/amm.94-96.2200.

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For the large cascaded hydropower stations, an electricity pricing mechanism of cascade hydropower stations on large basins is proposed. The main idea is that the electricity generated by different hydropower stations on the same river can be sold to the Grid Corporation with the same price. Using five hydropower stations on the middle and lower reaches of some river in China's south-western region as a case, the pricing methods based on the Operation-period pricing method are studied. The changes of hydropower stations' earnings are analyzed through the cascade hydropower stations optimal sch

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Zahlanie, Yorgo, Brenton Hall, Wenjing Wei, et al. "1061. Decreased Utilization of Piperacillin–Tazobactam for Escherichia coli and Klebsiella Bacteremia due to Selective Susceptibility Reporting." Open Forum Infectious Diseases 6, Supplement_2 (2019): S375—S376. http://dx.doi.org/10.1093/ofid/ofz360.925.

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Abstract Background Over 2 million people in the United States are diagnosed with antibiotic-resistant infections annually. The Infectious Diseases Society of America (IDSA) recommends cascade reporting of antibiotic susceptibility data by the clinical microbiology laboratory as an intervention to decrease resistance, though this is based on low-quality evidence. Methods We conducted a retrospective study to assess the effect of cascade susceptibility reporting on prescribing practices and patient outcomes. A cascaded testing algorithm was executed wherein susceptibility data for piperacillin–

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Zhang, Lei, Zahid Hussain, and Zhuanqin Ren. "Recent Advances in Rational Diagnosis and Treatment of Normal Pressure Hydrocephalus: A Critical Appraisal on Novel Diagnostic, Therapy Monitoring and Treatment Modalities." Current Drug Targets 20, no. 10 (2019): 1041–57. http://dx.doi.org/10.2174/1389450120666190214121342.

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Background:Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess Cerebrospinal Fluid (CSF) is accumulated in the brain’s ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, slurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.Objective:The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitor

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Percival, Michael E., Brian J. Martin, Jenna B. Gillen та ін. "Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle". Journal of Applied Physiology 119, № 11 (2015): 1303–12. http://dx.doi.org/10.1152/japplphysiol.00048.2015.

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We tested the hypothesis that ingestion of sodium bicarbonate (NaHCO3) prior to an acute session of high-intensity interval training (HIIT) would augment signaling cascades and gene expression linked to mitochondrial biogenesis in human skeletal muscle. On two occasions separated by ∼1 wk, nine men (mean ± SD: age 22 ± 2 yr, weight 78 ± 13 kg, V̇o2 peak 48 ± 8 ml·kg−1·min−1) performed 10 × 60-s cycling efforts at an intensity eliciting ∼90% of maximal heart rate (263 ± 40 W), interspersed with 60 s of recovery. In a double-blind, crossover manner, subjects ingested a total of 0.4 g/kg body wei

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Franco-Obregón, Alfredo, Yee Kit Tai, Kwan Yu Wu, Jan Nikolas Iversen, and Craig Jun Kit Wong. "The Developmental Implications of Muscle-Targeted Magnetic Mitohormesis: A Human Health and Longevity Perspective." Bioengineering 10, no. 8 (2023): 956. http://dx.doi.org/10.3390/bioengineering10080956.

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Muscle function reflects muscular mitochondrial status, which, in turn, is an adaptive response to physical activity, representing improvements in energy production for de novo biosynthesis or metabolic efficiency. Differences in muscle performance are manifestations of the expression of distinct contractile-protein isoforms and of mitochondrial-energy substrate utilization. Powerful contractures require immediate energy production from carbohydrates outside the mitochondria that exhaust rapidly. Sustained muscle contractions require aerobic energy production from fatty acids by the mitochondr

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Li, Chang. "Research on the traffic flow measurement method of intelligent connected vehicles based on series and cascade technology." Mathematical Modeling and Algorithm Application 2, no. 3 (2024): 17–20. http://dx.doi.org/10.54097/y98dwv38.

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At present, the major cities in our country have entered the development of smart cities, the utilization rate and prevalence rate of intelligent connected cars in smart cities have reached a new peak,to manage the real-time traffic flow of intelligent connected vehicles effectively in smart cities. This paper proposes to calculate the flow of intelligent connected vehicles based on series cascade technology. Firstly, this paper collects multi-source heterogeneous data based on multiple collectors; Secondly, a generative adversarial network is employed for data fusion, synthetic data, closely

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Li, Qi Min. "The Cascaded Utilization of Geothermal Resources." Applied Mechanics and Materials 178-181 (May 2012): 131–34. http://dx.doi.org/10.4028/www.scientific.net/amm.178-181.131.

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The geothermal resource is a clean complex resource, which can be changed into sustainable energy guided by the science theories. Demonstrating the heating engineering of a immigration village in Tianjin, the intention of this paper is to survey the sustainable utilization of geothermal resource meeting basic heating load, containing: (1) the dynamic prediction technologies of the production–reinjection of geothermal wells; (2) the design of inclined geothermal well; (3) the technologies of cascaded utilization of geothermal resource; and (4) the project appraisal. The results show geothermal

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Däbritz, J. Henry M., Maja Milanovic, Zhen Zhao, et al. "Acquired Stem Cell Properties In Therapy-Induced Senescence Of Lymphomas and Acute Leukemias In Vitro and In Vivo." Blood 122, no. 21 (2013): 4193. http://dx.doi.org/10.1182/blood.v122.21.4193.4193.

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Abstract Introduction Premature senescence is a permanent proliferative arrest that occurs in response to oncogenic signaling or DNA-damaging chemotherapy. Although tumor cell senescence has been recognized as a prognostically relevant contribution to long-term outcome post-therapy in hematological tumor models, therapeutic utilization of senescence is still hampered by an incomplete understanding of biological properties and long-term fate of senescent tumor cells in patients. Interestingly, senescence-regulating factors have recently been shown to limit reprogramming of somatic cells to plur

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Guan, Yue, Xiangdong Xu, and Haixiang Jia. "Dynamic Equilibrium Strategy of Power Battery Closed-Loop Supply Chain Based on Stochastic Differential Game." Mathematical Problems in Engineering 2022 (September 28, 2022): 1–17. http://dx.doi.org/10.1155/2022/3892748.

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The industrialization of new energy vehicles has accelerated, and the recycling industry driven by a large number of retired power batteries has exploded rapidly. How to control and deal with decommissioned batteries and balance economic and environmental benefits has become an urgent problem to be solved. Considering the influence of uncertain interference factors, the dynamic equilibrium strategy of power battery closed-loop supply chain members composed of leading manufacturer, recycler, and cascade utilization enterprise was studied. (1) This paper describes the stochastic evolution proces

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Tanyanskiy, D. A., and A. D. Denisenko. "The influence of adiponectin on carbohydrates, lipids, and lipoproteins metabolism: analysis of signaling mechanisms." Obesity and metabolism 18, no. 2 (2021): 103–11. http://dx.doi.org/10.14341/omet12754.

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Dysregulation of adipose tissue functions makes a significant contribution to the pathogenesis of metabolic syndrome, one of the most common diseases in recent years. Adipose tissue is an organ that secretes at least several dozen signaling molecules, adipokines. One of the most studied and at the same time mysterious adipokines is adiponectin. The latter is due to the lack of clear ideas about the biological role of this adipokine, the presence of its several molecular forms with different activity and several types of receptors to this adipokine localized in almost all cells of the body. The

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Bhattacharjee, Soumen. "The Language of Reactive Oxygen Species Signaling in Plants." Journal of Botany 2012 (February 15, 2012): 1–22. http://dx.doi.org/10.1155/2012/985298.

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Reactive oxygen species (ROS) are astonishingly versatile molecular species and radicals that are poised at the core of a sophisticated network of signaling pathways of plants and act as core regulator of cell physiology and cellular responses to environment. ROS are continuously generated in plants as an inevitable consequence of redox cascades of aerobic metabolism. In one hand, plants are surfeited with the mechanism to combat reactive oxygen species, in other circumstances, plants appear to purposefully generate (oxidative burst) and exploit ROS or ROS-induced secondary breakdown products

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