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Journal articles on the topic 'V. amygdalina'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Shui, Lanya, Kaisen Huo, Yan Chen, Zilin Zhang, Yanfang Li, and Jun Niu. "Integrated metabolome and transcriptome revealed the flavonoid biosynthetic pathway in developing Vernonia amygdalina leaves." PeerJ 9 (April 26, 2021): e11239. http://dx.doi.org/10.7717/peerj.11239.

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Background Vernonia amygdalina as a tropical horticultural crop has been widely used for medicinal herb, feed, and vegetable. Recently, increasing studies revealed that this species possesses multiple pharmacological properties. Notably, V. amygdalina leaves possess an abundance of flavonoids, but the specific profiles of flavonoids and the mechanisms of fl avonoid bi osynthesis in developing leaves are largely unknown. Methods The total flavonoids of V. amygdalina leaves were detected using ultraviolet spectrophotometer. The temporal flavonoid profiles of V. amygdalina leaves were analyzed by

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2

Nguemfo Tchankugni, Arlette, Mpoame Mbida, Jürgen Hescheler, and Filomain Nguemo. "Effect of Ethanolic Extract of Vernonia amygdalina on the Proliferation, Viability and Function of Mouse Induced Pluripotent Stem Cells and Cardiomyocytes." Plants 12, no. 5 (2023): 1108. http://dx.doi.org/10.3390/plants12051108.

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Vernonia amygdalina (V. amygdalina) leaves are commonly used in traditional medicine around the world for the treatment of a plethora disorders, including heart disease. The aim of this study was to examine and evaluate the cardiac effect of V. amygdalina leaf extracts using mouse induced pluripotent stem cells (miPSCs) and their cardiomyocytes’ (CMs) derivatives. We used a well-established stem cell culture to assess the effect of V. amygdalina extract on miPSC proliferation, EB formation and the beating activity of miPS cell-derived CMs. To study the cytotoxic effect of our extract, undiffer

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3

K, Igwe, Ikpeazu O, and Otuokere I. "Evaluation the Effect of Vernonia amygdalina. Del Leaves Ethanol Extract on Blood Sugar and its Synergism with Glibenclamide in Rats." Al-Anbar Journal of Veterinary Sciences 13, no. 1 (2020): 26–34. http://dx.doi.org/10.37940/ajvs.2020.13.1.4.

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Antidiabetic activity of Vernonia amygdalina and its possible synergism with glibenclamide was checked. Forty eight rats were used for the research, for hypoglycermic study of V. amygdalina alone, they were grouped into five of six rats each. Group 1 was the negative control and was administered distilled water orally. Groups 2, 3, and 4 were the treatment groups which received 100, 200 and 300 mg/kg body weight of the V. amygdalina extract respectively orally by intubation. Group 5 was the positive control group which received a known antidiabetic drug, glibenclamide. Diabetes was induced wit

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4

D.O., Ejembi,, Daniel, B.C., Adejoh, O., et al. "Comparative Study on the Effect of Aqueous Extract of Moringa Oleifera and Vernonia Amygdalina Leaves on Some Biochemical Indices of Male Wistar Rats." International Journal of Research and Scientific Innovation XII, no. V (2025): 220–26. https://doi.org/10.51244/ijrsi.2025.12060019.

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Metabolic disturbances are sometimes due to alterations in some biochemical parameters and thereby become an indicator for the assessment of metabolic syndrome. The present study evaluates the comparative effects of aqueous extract of Moringa oleifera and Vernonia amygdalina on some biochemical indices in male adult Wister rats. Thirty-two adult male Wister rats of average weight of 152 g. Rats were randomly assigned into four groups of eight each. Group one served as the control and each rat in this group received 2ml of distilled water orally and daily. Groups two and three received 2.5 g/ml

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5

Oklusola-Mainde, Olubukola Olayemi, and Michael Tosin Bayode. "Comparative antimicrobial study of Vernonia amygdalina Del. and Lawsonia inermis L. against microorganisms from aqueous milieu." European Journal of Biological Research 11, no. 3 (2021): 283–93. https://doi.org/10.5281/zenodo.4742538.

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Limitations have been concurrent with the use of antibiotics in chemotherapy. Hence, antimicrobial potency of aqueous and ethanol leaf extracts of <em>Vernonia amygdalina</em> and <em>Lawsonia inermis</em> on some selected multiple antibiotic resistant bacteria and fungi isolated from stream were compared. The phytochemical evaluation and antimicrobial susceptibility test of MAR bacteria and fungi was achieved via CLSI reference standard of perfloxacin (10 µg) and ketoconazole (150 mg/ml) with susceptibility index (>14.00 mm and >15.00 mm, respectively) as control for bacteria and

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6

OSAGIE, O. A., N. B. AGUEBOR-OGIE, and G. E. ERIYAMREMU. "THE EFFECT OF METHANOLIC EXTRACT OF Vernonia amygdalina ON LIPID PEROXIDATION AND SOME ANTIOXIDANT ENZYME ACTIVITIES IN THE EARLY STAGE OF CYCASIN INDUCED TESTICULAR CARCINOGENESIS IN RATS." Nigerian Journal of Life Sciences (ISSN: 2276-7029) 4, no. 1 (2022): 175–80. http://dx.doi.org/10.52417/njls.v4i1.169.

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This study evaluated the effect of Vernonia amygdalina (V. amygdalina) on testicular lipid peroxidation, Superoxide Dismutase (SOD) and catalase (CAT) activities in the early stages of cycasin-induced testicular carcinogenesis in rats. Fifty male Wistar rats with an average weight of 175g were divided into five groups of 10 animals each. Group 1 was fed with a Normal Diet (ND) and acted as experimental control. Group 2 was fed with a Normal Diet compounded with cycasin for 6 weeks. Group 3 to Group 5 were fed with Normal Diet compounded with cycasin V. amygdalina in varied amount and duration

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7

Afuye, O. O., and S. O. Omotayo. "Evaluation of In vitro Anti-Diabetic Properties of Biosynthesized Magnesium Oxide Nanoparticles from Vernonia amygdalina (Bitter Leaf) Aqueous Leaf Extract." European Journal of Medicinal Plants 35, no. 1 (2024): 45–55. http://dx.doi.org/10.9734/ejmp/2024/v35i11178.

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Introduction: Vernonia amygdalina is a common shrub that is widely used and extracts from them have been traditionally used as remedies for treating diabetes mellitus in various parts of the world. The use of V. amygdalina to synthesize MgO nanoparticles has been used for various biomedical applications and it is compatible with anti-diabetic studies. This research investigates the in vitro anti-diabetic potentials of biosynthesized from aqueous V. amygdalina leaf extract. Methodology: Aqueous extract of V. amygdalina-MgO nanoparticles were characterized using Fourier Transform Infrared, X-ray

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8

Sukarjati, Sukarjati, and Ganda Adi Nugroho. "Potensi Ekstrak Daun Afrika (Vernonia amygdalina), Daun Pepaya (Carica papaya L) Serta Kombinasi Kedua Ekstrak Terhadap Jumlah Folikel Primer, Sekunder dan Tersier Pada Mencit (Mus musculus)." Wahana 73, no. 2 (2021): 39–57. http://dx.doi.org/10.36456/wahana.v73i2.4513.

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African leaf (Vernonia amygdalina) and papaya leaf (Carica papaya L) are plants that contain secondary metabolites and are thought to have antifertility effects. V amygdalina and C papaya L leaves contain flavonoids, saponins, tannins, and alkaloids. The purpose of this study was to prove that V amygdalina leaf extract, C papaya L leaf and the combination of the two extracts could reduce the number of primary, secondary and tertiary follicles. This study used 44 female mice. Extraction was carried out by maceration . The doses of V amygdalina leaf extract and C papaya L leaf extract used were

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9

Ajayi, Abayomi, Titilayo Ige, Nich Arawa Ude, et al. "Aqueous extract of bitter leaf Vernonia amygdalina Delile (Asterales: Asteraceae) ameliorates testosterone-induced benign prostatic hyperplasia (BPH) in Wistar rats." Brazilian Journal of Biological Sciences 4, no. 7 (2017): 45–52. http://dx.doi.org/10.21472/bjbs.040706.

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Benign prostatic hyperplasia (BPH) is an age-dependent condition involving prostate enlargement which may lead to lower urinary tract symptoms (LUTS). This study was designed to study the ameliorative effect of the aqueous extract of bitter leaf Vernonia amygdalina Delile (Asterales: Asteraceae) on testosterone-induced BPH in a rat model. Thirty adult male Wister rats were randomly divided into six groups (A to F), with BPH induced through a single subcutaneous injection of 5 mg/kg of testosterone propionate (TP) and Vernonia amygdalina administered in various doses through oral gavage for 14

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10

Emiri, U. N., and E. B. Enaregha. "Phytochemical screening and antifungal potency of Vernonia amygdalina (bitter leaf) extract against post harvest mycodeterioration of tomato (Lycopersicum esculentum)." Brazilian Journal of Biological Sciences 7, no. 17 (2020): 327–37. http://dx.doi.org/10.21472/bjbs(2020)071708.

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The study investigated fungi associated with post harvest tomato fruits sold in the open market in Port Harcourt Metropolis. The antifungal activity (bitter leaf) extracts against spoilage was studied using well-in-agar diffusion method. Results showed that mean percentage incidence of fungi isolated from tomato fruits were Rhizopus stolonifer (56%), Aspergillus niger (62%) and Altermaria altermata (35%). Aqueous and ethanolic extracts of Vernonia amygdalina at different concentrations (20%, 40%, and 60%) (w/v) were used against fungi isolates, while water and ketoconzole (0.5 mg/mL) served as

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11

Awwaliah, Mardhatillah, Mukhriani Mukhriani, Nur Asma, and Muhammad Ikhlas Arsul. "Korelasi Kadar Fenol dan Flavonoid terhadap Indeks Aktivitas Antioksidan Ekstrak Batang Vernonia amygdalina." Jurnal Sains dan Kesehatan 5, no. 5 (2023): 652–58. http://dx.doi.org/10.25026/jsk.v5i5.1959.

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Bitter leaf (in Africa) is the most widely cultivated species of the genus Vernonia which is the most prominent in the family Asteraceae that has been studied in Africa. African leaves have been widely used for traditional medicine and/or treating various human diseases. This study aimed to determine the bioactive compounds that correlate to the antioxidant activity of V. amygdalina stem. Extraction of V. amygdalina stem was carried out by reflux method. Determination of total phenol and flavonoid content was done spectroscopically. Antioxidant activity was measured based on antioxidant activi

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Awwaliah, Mardhatillah, Mukhriani Mukhriani, Nur Asma, and Muhammad Ikhlas Arsul. "Korelasi Kadar Fenol dan Flavonoid terhadap Indeks Aktivitas Antioksidan Ekstrak Batang Vernonia amygdalina." Jurnal Sains dan Kesehatan 5, no. 5 (2024): 652–58. https://doi.org/10.30872/jsk.v5i5.561.

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Daun afrika merupakan spesies yang paling banyak dibudidayakan dari genus Vernonia yang paling menonjol dalam famili Asteraceae yang telah dipelajari di Afrika. Daun afrika telah banyak digunakan untuk pengobatan tradisional dan/atau mengobati berbagai penyakit pada manusia. Tujuan dari penelitian ini adalah untuk mengetahui senyawa bioaktif yang berkorelasi terhadap aktivitas antioksidan dari batang V. amygdalina. Ekstraksi batang V. amygdalina dilakukan dengan metode refluks. Penentuan kadar fenol dan flavonoid total dilakukan secara spektroskopi. Aktivitas antioksidan diukur berdasarkan ind

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13

Davies, Koofreh, Emmanuel Olorunsola, Nathaniel Udokang, Kubiat Umana, Mfonobong Alozie, and Innocent Edagha. "Ameliorative Effects of Vernonia amygdalina and Moringa oleifera Extracts on Cognitive Impairment in Diabetic Wistar Rats." NIgerian Journal of Neuroscience 13, no. 2 (2022): 67–76. http://dx.doi.org/10.47081/njn2022.13.2/004.

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This study investigated the ameliorative effects of Vernonia amygdalina and Moringa oleifera on cogni-tive impairment in alloxan-induced diabetes mellitus in male Wistar rats. The animals were allotted into eight groups of five. Group 1 were not induced nor treated. Diabetes was induced with alloxan (135 mg/kg body weight) in groups 2-8. Group 2 which served as diabetic control received distilled water (10 mL/kg). Groups 3-8 were administered ethanol extracts of V. amygdalina (200 mg), M. oleifera (500 mg), V. amygdalina (400 mg), M. oleifera (1,500 mg), V. amygdalina (300 mg) + M. oleifera (1

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14

Rotimi, Damilare Emmanuel, Goodnews Mavoghenegbero Ben-Goru, Ikponmwosa Owen Evbuomwan, et al. "Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain." Evidence-Based Complementary and Alternative Medicine 2022 (September 26, 2022): 1–9. http://dx.doi.org/10.1155/2022/9470178.

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The study investigated the effects of Zingiber officinale root and Vernonia amygdalina leaf on the brain redox status of Wistar rats. Twenty-four (24) rats weighing 160 ± 20 g were randomly assigned into four (4) groups, each with six (6) rats. Animals in Group 1 (control) were orally administered distilled water (1 mL), while the test groups were orally administered 5 mg/mL of either Z. officinale, V. amygdalina infusion, or a combination of both, respectively, for 7 days. The rats were sacrificed at the end of treatments and blood and tissue were harvested and prepared for biochemical assays

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15

Chainanta, Jiratchaya, Kittiporn Yakajay, Chanakarn Chinda, et al. "Vernonia amygdalina Extract Loaded Microspheres for Controlling Phytophthora palmivora." Sustainability 15, no. 14 (2023): 10842. http://dx.doi.org/10.3390/su151410842.

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The adverse effects of modern fungicide consumption have caused many issues in the agroecosystem. Hence, under sustainable agriculture concepts, it is important to research alternatives to the currently used fungicide. The use of secondary metabolite-containing herbal extracts for treating plant diseases has become the latest trend in sustainable and green agriculture. However, the poor solubility and volatile nature of many compounds cause practical issues when using them in the field. Hence, bioactive compound delivery through nano- or micro-particles has become a successful technique to imp

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16

Haqqi, Arini Nurul, and Wahyuni Wahyuni. "Uji EfektiviUji Efektivitas Ekstrak Etanol Kombinasi Daun Afrika (Vernonia Amygdalina Del.) dan Daun Kluwih (Artocarpus Camansi) Terhadap Penurunan Kadar Asam Urat Pada Mencit (Mus Musculus)tas Ekstrak Etanol Kombinasi Daun Afrika (Vernonia Amygdalina Del.) dan Daun Kluwih (Artocarpus Camansi) Terhadap Penurunan Kadar Asam Urat Pada Mencit (Mus Musculus)." Pharmacy Genius 2, no. 1 (2023): 1–12. http://dx.doi.org/10.56359/pharmgen.v2i1.168.

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Pendahuluan: Penyakit asam urat atau gout merupakan salah satu kategori penyakit kronis tidak menular, yang di tandai dengan adanya hiperurisemia atau peningkatan kadar asam urat dalam darah. Tujuan: Untuk mengetahui konsentrasi berapa dari kombinasi ekstrak daun afrika (Vernonia amygdalina Del.) dan daun kluwih (Artocarpus camansi) yang efektif dalam menurunkan kadar asam urat mencit (Mus musculus). Metode: Penelitian ini merupakan eksperimental laboratorium dengan menggunakan metode RAL (Rancangan Acak Lengkap) dan selanjutnya dilakukan analisis data menggunakan uji one way ANOVA yang dibagi

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17

Chijindu, Pass C., Onyeka B. Onyeukwu, and Udomah Ogheneoruese. "Evaluation of Nutritional, Phytochemicals and Antioxidant Capacity of Telfairia Occidentalis F. and Vernonia Amygdalina Delile Leaves." Nigerian Journal of Biochemistry and Molecular Biology 39, no. 3 (2024): 170–77. https://doi.org/10.4314/njbmb.v39i3.8.

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This study assessed the nutritional composition, phytochemical constituents, and antioxidant activities of Telfairia occidentalis and Vernonia amygdalina leaves. Standard analytical methods were employed to evaluate the powdered and aqueous extracts of both plants. Findings indicated that T. occidentalis exhibited higher levels of moisture (11.43%), crude fiber (9.11%), protein (8.19%), and crude lipid (3.67%) compared to V. amygdalina. No significant difference was observed in total ash content between the two species. Qualitative phytochemical analysis identified the presence of saponins, ca

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18

C. Oladele, Funmilola. "Therapeutic Efficacy of Vernonia amygdalina and Persea americana Extracts in Mitigating Endothelial Dysfunction, Oxidative Stress, and Cardiac Biomarkers in Lipopolysaccharide-Induced Hypertension during Pregnancy." Journal of Obstetrics Gynecology and Reproductive Sciences 9, no. 3 (2025): 01–10. https://doi.org/10.31579/2578-8965/264.

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Objective: This study investigates the therapeutic efficacy of Vernonia amygdalina and Persea americana extracts in mitigating lipopolysaccharide-induced hypertension during pregnancy, focusing on endothelial dysfunction, oxidative stress, and cardiac biomarkers in albino rats. Materials and Methods: V. amygdalina and P. americana samples were collected, dried, powdered, and extracted using ethanol. Fifty-four pregnant Wistar rats were divided into nine groups, including a control group, an LPS-only group, and groups treated with various dosages of V. amygdalina and P. americana extracts. The

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Elizabeth Obioma Nweke, Cosmas Chiedozie Ofoegbu, Melford Uche Elendu, Chijioke Ikejiaku Ugboaja, and Eziamaka Okechukwu Daniel. "Evaluation of the effect of ethanol leaf extract of Vernonia amygdalina on the Testicle of Diabetic Wistar Rats." GSC Biological and Pharmaceutical Sciences 20, no. 2 (2022): 220–25. http://dx.doi.org/10.30574/gscbps.2022.20.2.0300.

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The aim of this study was to evaluate the effect of ethanol leaf extract of V. amygdalina on the testicle of alloxan induced diabetic wistar rats. Freshly harvested leaves of V. amygdalina was washed with clean tap water and subsequently dried at room temperature prior to being ground to fine powder. Twenty (20) adult male wistar rats were divided into four (4) groups of five (5) rats per group. · Group I was the normal control and was fed rat chow and water · Group II was induced diabetes without treatment, while · Groups III and IV were diabetic rats administered with 100 mg/kg and 200 mg/kg

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Bbosa, Godfrey S., Robert Lubajo, Aloysius M. Lubega, Gordon Odia, and John Katerega. "Effects of leaf extracts of Vernonia amygdalina on the force and rate of contractility of an isolated mammalian heart." International Journal of Basic & Clinical Pharmacology 8, no. 11 (2019): 2389. http://dx.doi.org/10.18203/2319-2003.ijbcp20194773.

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Background: Vernonia amygdalina is a common medicinal plant that is widely used by local communities and traditional herbalists in central Uganda in management of various conditions including hypertension that occurs as a result of changes in heart contractility. However, there is limited scientific information of V. amygdalina effects on the force and rate of contractility of the heart. The study evaluated the inotropic and chronotropic effect of methanol, aqueous, ether and total crude leaf extracts of V. amygdalina on isolated perfused rabbit heart.Methods: An experimental laboratory based

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Omeodu, SI, and PO Uahomo. "ANTI-HYPERGLYCEMIC AND HEPATOPROTECTIVE PROPERTIES OF COMBINED AQUEOUS LEAF EXTRACT OF Vernonia amygdalina AND Moringa oleifera IN EXPERIMENTALLY INDUCED DIABETIC RAT MODEL." International Journal of Recent Research in Life Sciences (IJRRLS) 10, no. 1 (2023): 1–7. https://doi.org/10.5281/zenodo.7496485.

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<strong>Abstract:</strong> This study was carried out to investigate the anti-hyperglycemic and hepato-protective properties of combined leaf extracts of <em>Vernonia amygdalina</em> and <em>Moringa oleifera</em> in alloxan-induced diabetic Wistar rats. The study design involved 25 rats weighing 140 to 2100g which were randomly divided into 5 groups of 5 rats each. Group 1 received distilled water and feed; group 2 received no treatment; group 3 received 4% extract combination of <em>V. amygdalina</em> and <em>M. oleifera</em>; group 4 received 8% extract combination of <em>V. amygdalina</em>

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Ilechukwu, C. C., C. O. Ezenwelu, J. C. Ifemeje, J. N. Ilechukwu, and I. H. Iheukwumere. "Comparative Assessment of the In vitro Antioxidant Activity and Phytochemical Analysis of Vernonia amygdalina Leaf and Ocimum gratissimum Leaf." IPS Journal of Drug Discovery Research and Reviews 3, no. 1 (2025): 38–43. https://doi.org/10.54117/ijddrr.v3i2.33.

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Vernonia amygdalina and Ocimum gratissimum are a major part of the diet in many Nigerian families due to their wide culinary applications and appeal. This study, therefore, compared the in-vitro antioxidant activity and phytochemical content of the extracts of these two plants. The methanol extracts of freshly plucked leaves of Vernonia amygdalina and Ocimum gratissimum were obtained and extracted using standard procedures. The phytochemical composition and in-vitro antioxidant parameters (nitric oxide and hydrogen peroxide) were assessed. The results of the phytochemical screening of methanol

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Mwanda, R. Nasson, A. Luseko Chilagane, R. Belmain Steven, and S. Loth Mulungu. "Effects of Combination of Plant Extracts for the Control of Black Bean Aphids and other Beneficial Insects on Common Beans." INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGICAL SCIENCES 7, Jan & Feb 2023 (2023): 32–46. https://doi.org/10.5281/zenodo.7689151.

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<em>An experiment was conducted during wet and dry seasons at Ndugutu village from December, 2020 to August, 2021 to investigate effects of combinations of three selected pesticidal plants for the control of Black Bean Aphids(BBAs) and their effects on beneficial insects on common bean crop (Phaseolus vulgaris L). The experimental design was Randomized Complete Block Design with three replications. The combinations of pesticidal plant species extracts of D. trifoliata, D. ambrosioides and V. amygdalina (DT: DA: VA), D. trifoliata and D. ambrosioides (DT: DA), D. trifoliata and V. amygdalina (D

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Alara, OR, NH Abdurahman, CI Ukaegbu, and OU Osazuwa. "Antibacterial Activity of Vernonia amygdalina and Vernonia cinerea Leaf Extracts through Microwave-Assisted Extraction Technique." Nigerian Research Journal of Engineering and Environmental Sciences 07, no. 02 (2022): 413–19. https://doi.org/10.5281/zenodo.7496588.

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<em>The occurrence of multi-drug-resistant bacteria has been a great challenge facing public health care in recent times. Therefore, this study investigated the antibacterial activity of extracts from two species of Vernonia (Vernonia amygdalina and Vernonia cinerea) against Bacillus cereus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli. The results obtained showed that the tested bacteria were sensitive to extracts from both plant samples in the concentration range of 6 to 30 mg/mL. Higher sensitivities were seen at a concentration of 30 mg/mL. Moreover, the sensitivitie

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Boadu, A., S. Singh, R. Karpoormath, and M. Nlooto. "REVIEW ON ETHNOMEDICINAL USES, PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL EVIDENCE ON LEAF EXTRACT OF PERSEA AMERICANA AND VERNONIA AMYGDALINA OF THE AFRICAN CONTINENT - A REVIEW." INDIAN DRUGS 56, no. 01 (2019): 7–24. http://dx.doi.org/10.53879/id.56.01.11623.

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People on the African continent frequently consume Persea americana and Vernonia amygdalina for food and medicinal purposes. The review is an effort to compile ethnomedicinal, phytochemical and pharmacological knowledge is the above two plants from the year 2000 till now. A search was carried out using a combination of several keywords : Persea americana, Vermonia amygdalina, traditional medicine, ethnomedicine, avocado, bitter leaf and integrated approaches. Published papers in English language were retrieved from the online bibliographical databases: Web of Science, PubMed, Google Scholar, S

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Eraga, LI, E. Aganbi, AA Anigboro, SO Asagba, and NJ Tonukari. "Antigenotoxicity and antioxidant activities of bitter leaf (Vernonia amygdalina del.) accessions from different parts of Nigeria." African Journal of Food, Agriculture, Nutrition and Development 22, no. 4 (2022): 20161–80. http://dx.doi.org/10.18697/ajfand.109.20355.

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Bitter leaf (Vernonia amygdalina Del.) plant is a tree species that is highly cultivated in Nigeria for its nutritive and therapeutic values. This study aimed to determine the antioxidant and antigenotoxicity effects (in vitro) of 52 accessions of V. amygdalina collected from six geopolitical zones of Nigeria (North East, North West, North Central, South South, East and West) by evaluating the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO-) scavenging antioxidant activities, flavonoid and phenolic contents as well as ethidium bromide-induced DNA (deoxyribonucleic acid) damage of bi

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A., I. Nta, E. Agbo B., and S. Udoekong N. "Bio-insecticidal and Grain Protectant Activities of Mixed Powder of Ocimum gratissimum and Vernonia amydalina against Callosobruchus maculatus (Coleoptera: Bruchidae) in Calabar, Nigeria." Asian Journal of Biology 2, no. 3 (2017): 1–7. https://doi.org/10.9734/AJOB/2017/33500.

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The bio-insecticidal and grain protectant activities of mixed powder of <em>Ocimum gratissimum</em> and <em>Vernonia amygdalina </em>upon <em>Callosobruchus maculatus</em> was carried out in Calabar, Nigeria during the dry season (August to November) of 2015. The mortality rate of cowpea weevil treated <em>V. amygdalina</em>: <em>O. gratissimum</em> at 100: 0 concentrations were 17.0%, 27.0%, and 47.0% for a period of 24hrs, 48hrs and 72hrs, respectively. Concentrations 0:100 gave a percentage mortality of 47.0%, 67.0% and 73.0% at 24hrs, 48hrs and 72hrs, respectively. 80: 20 and 20: 80 concen

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EHI-Omosun, MB, and GI EZE. "Effects of Aqueous Leaf Extract of Vernonia amygdalina on High-Fat Diet-Induced Injury in the Heart and Aorta of the Adult Wistar Rat." Journal of Phytopharmacology 12, no. 2 (2023): 93–99. http://dx.doi.org/10.31254/phyto.2023.12205.

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The aim of this study was to investigate the effects of aqueous leaf extract of Vernonia amygdalina in Wistar rats fed with high-fat diet. 30 adult Wistar rats weighing between 250g and 280g were randomly assigned into 5 groups of 6 rats per group. Group A rats were placed on rat food and water only. Group B rats received 1000mg/kg body weight / day (BWT/D) of margarine. Group C rats received 300mg/kg BWT/D of V. amygdalina. Group D rats received 1000mg/kg BWT/D of margarine and 150mg/kg BWT/D of V. amygdalina. Group E rats received 1000mg/kg BWT/D of margarine and 300mg/kg BWT/D of V. amygdal

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Elizabeth, Obioma Nweke, Chiedozie Ofoegbu Cosmas, Uche ElenduChijioke Ikejiaku Ugboaja Melford, Ikejiaku Ugboaja Chijioke, and Okechukwu Daniel Eziamaka. "Evaluation of the effect of ethanol leaf extract of Vernonia amygdalina on the Testicle of Diabetic Wistar Rats." GSC Biological and Pharmaceutical Sciences 20, no. 2 (2022): 220–25. https://doi.org/10.5281/zenodo.7139834.

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The aim of this study was to evaluate the effect of ethanol leaf extract of <em>V. amygdalina</em> on the testicle of alloxan induced diabetic wistar rats. Freshly harvested leaves of <em>V. amygdalina</em> was washed with clean tap water and subsequently dried at room temperature prior to being ground to fine powder. Twenty (20) adult male wistar rats were divided into four (4) groups of five (5) rats per group. ·         Group I was the normal control and was fed rat chow and water ·      

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Gloria, N. Elemo, O. Malik Lasisi, B. Mercy Adekunle, A. Prosper Akinleye, and T. Precious Bello. "Biochemical Evaluation of Vernonia amygdalina on the Haematology, Kidney Profile and Liver Function Tests in Wistar Rats." International Journal of Innovative Science and Research Technology 8, no. 5 (2023): 581–89. https://doi.org/10.5281/zenodo.7950874.

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Obesity and overweight contribute significantly to the burden of chronic diseases and complications globally. The rising prevalence of these conditions in Nigeria, especially among middle-class workers has been attributed to the acculturation of Western dietary patterns, reduced intake of dietary fibre, and sedentary lifestyles. Considering the risks associated with obesity and the associated side effects of orthodox medicine, a lot of studies have been dedicated to finding alternative treatments with limited side effects that are affordable hence, the use of medicinal plants such as Vernonia

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Okanume, Ogochukwu Esther, Solomon Gabriel Abok, and Oluwatobi Adekunle Oso. "Leaf epidermal and petiole anatomical features as taxonomic characters in some Vernonia species in Nigeria." Bio-Research 20, no. 1 (2022): 1388–97. http://dx.doi.org/10.4314/br.v20i1.1.

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Foliar and petiole micro-morphological characteristics of some members of the genus Vernonia namely; Vernonia amygdalina Del. (bitter variety), Vernonia amygdalina Del. (non-bitter variety), Vernonia cinerea (L) Less., Vernonia galamensis (Cass.) Less., and Vernonia adoensis Sch. Bip. in Jos, Nigeria was investigated to provide additional micro-morphological characters to support existing taxonomic information regarding the species. Epidermal peels of fresh leaves were made and transverse sections of petioles were cut using a rotary microtome. Staining was done using Safranin and slides observ

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Medjiofack Djeujo, Francine, Federico Cusinato, Eugenio Ragazzi та Guglielmina Froldi. "α-Glucosidase and advanced glycation end products inhibition with Vernonia amygdalina root and leaf extracts: new data supporting the antidiabetic properties". Journal of Pharmacy and Pharmacology 73, № 9 (2021): 1240–49. http://dx.doi.org/10.1093/jpp/rgab057.

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Abstract Objective This study aims to investigate antidiabetic activity of several Vernonia amygdalina extracts to study their potential use in medicine. Methods Aqueous and ethanol extracts were obtained by maceration and Soxhlet extraction from roots and leaves of V. amygdalina. The extracts were tested as inhibitors of α-glucosidase activity and of advanced glycation end products (AGEs) formation. Further, radical scavenging activity was examined detecting the oxygen radical absorbance capacity, while the potential cytotoxicity of extracts was estimated with MTT assay. Key findings In aqueo

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Bukar, AM, MA Isa, HS Bello, and AS Abdullahi. "Antibacterial Activityof Aqueous And Ethanolic Leaf Extracts Of Vernonia Amygdalina On Selected Species Of Gram Positive And Gram Negative Bacteria." International Journal of Environment 2, no. 1 (2013): 147–52. http://dx.doi.org/10.3126/ije.v2i1.9217.

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The phytochemical screening and antibacterial activity of ethanolic and Methanolic leaves extract of Vernonia amygdalina against five clinical isolates (Staphylococcus aureus, E. coli, Pseudomonas species, Salmonella species and Proteus species) was determined using standard method of analysis. The results of the antibacterial activity of ethanol, methanol and aqueous extract of leaves of V. amygdalina have diameters ranging between 0.4 to 10mm. The plant extracts from the plants had profound activities against gram-positive than gram negative bacteria. From the above studies, it has clearly i

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Abdulrahman, A., M. G. Garba, S. Gaddafi, and A. Yusuf. "RESPONSE OF YANKASA RAMS TO VARIOUS INCLUSION LEVELS OF PROPAGATED BITTER LEAF (Vernonia amygdalina) ON PERFORMANCE AND RUMEN ECOLOGY." FUDMA Journal of Animal Production and Environmental Science 1, no. 1 (2025): 46–51. https://doi.org/10.33003/japes.2025.v1i1.46-51.

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The experiment evaluated the response of Yankasa rams fed graded levels of propagated Bitter Leaf (Vernonia amygdalina) on growth performance, nutrient digestibility, rumen ecology, and blood profile. Twenty (20) rams were randomly allocated into four dietary treatments consisting of 0%, 5%, 10%, and 15% inclusion levels of dry bitter leaf. Growth performance, nutrient digestibility trail and rumen fluid were collected and analyzed accordingly. Data obtained were analyzed using statistical analysis system (SAS,2002). Growth performance results showed that T3(15%) had an outstanding (P<0.05)

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Lubis, Muhammad Fauzan, Poppy Anjelisa Zaitun Hasibuan, Hafid Syahputra, Ririn Astyka, and Intan Baruna. "Phytochemical Profile and Pharmacological Activity of Vernonia amygdalina Delile Stem Bark Extracts Using Different Solvent Extraction." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 860–66. http://dx.doi.org/10.3889/oamjms.2022.8921.

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BACKGROUND: Vernonia amygdalina is a native plant from Africa which is widely distributed to Asia, especially in Indonesia. Parts of V. amygdalina such as roots, leaves, and bark are used by the community as traditional medicines such as antidiabetic, antibacterial, and anticancer. AIM: This study aims to show the effect of solvents in the V. amygdalina stem bark extraction process on phytochemical’s content and their correlation with pharmacological activities. METHODS: V. amygdalina extract from stem bark in this study was obtained using the maceration method with different solvents. The ext

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Yeigba B Japhet and Tule Godgift. "Effect of Vernonia amygdalina leaf extract on growth performance, carcass characteristics of pullet and broiler birds." International Journal of Science and Research Archive 3, no. 2 (2021): 209–13. http://dx.doi.org/10.30574/ijsra.2021.3.2.0164.

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A six week experimental trial was conducted to determine “The effect of Vernonia amygdalina leaf extract on the growth performance, carcass characteristics of broilers and pullets birds”. The experiment was carried out at the poultry unit of the Teaching and Research Farm of the Niger Delta University, Wilberforce Island Bayelsa state. Forty (40) day old chicks were used for the experiment comprising of two genotypes, twenty broilers and twenty pullets. Each genotype was divided into treatment and control. The treatment was administered 50ml V. amygdalina leaf extract was diluted into 1 litre

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I. Nwabueze, Rose. "ANALYSIS OF THE SECONDARY METABOLITES OF VERNONIA AMYGDALINA AND THE ANTIMICROBIAL EFFECTS ON PATHOGENIC ORGANISMS." International Journal of Advanced Research 10, no. 02 (2022): 686–92. http://dx.doi.org/10.21474/ijar01/14256.

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Medicinal plants have assumed the basis of traditional treatment and have proven effective in human health care worldwide. There is an increasing interest in complementary and alternative therapies to treat various illnesses. The continued consumption of antibiotics with little or no impact on bacteria has negatively affected health care delivery. Bitter leaf (Vernonia amygdalina) is a common shrub belonging to the family Asteraceae and a perennial shrub usually cultivated as a homestead vegetable and fodder tree in various parts of Nigeria. The current study examined the effect of bitter leaf

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Dégbé, Mlatovi, Françoise Debierre-Grockiego, Amivi Tété-Bénissan, et al. "Extracts of Tectona grandis and Vernonia amygdalina have anti-Toxoplasma and pro-inflammatory properties in vitro." Parasite 25 (2018): 11. http://dx.doi.org/10.1051/parasite/2018014.

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Tectona grandis (teak) and Vernonia amygdalina (bitter leaf) are plants used in traditional medicine in West Africa. In this study, we tested ethanolic and hydro-ethanolic extracts of bark and leaves of T. grandis and ethanolic extract of leaves of V. amygdalina for their inhibitory effect on Toxoplasma gondii, a protozoan parasite responsible for toxoplasmosis. Ethanolic extract of V. amygdalina leaves had proportional contents of phenols, tannins, flavonoids, and polysaccharides. This extract presented the highest efficacy against T. gondii, the lowest cytotoxicity to mammalian cells, but mo

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Musyoki, David. "Exploring the Antibacterial Properties of Vernonia amygdalina (Bitter Leaf) Extract: A Potential Alternative to Conventional Antibiotics." NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES 5, no. 1 (2024): 60–67. http://dx.doi.org/10.59298/nijbas/2024/5.1.606711.

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As part of the ongoing search for potent and resistance-free antibacterial medicinal plants, this study aimed to evaluate the antibacterial properties of the plant extract of Vernonia amygdalina, commonly known as bitter leaf. Standard procedures were used to provide a potential cheap alternative to conventional medication for treating bacterial infections. The aqueous extract of V. amygdalina leaves was prepared and subjected to phytochemical screening, which revealed the presence of tannins, phlobatannins, saponins, terpenoids, cardiac glycosides and alkaloids. The antibacterial activity of

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Adheline, Ghaaliya Dyah. "DAUN AFRIKA (Vernonia amygdalina) SEBAGAI ALTERNATIF ANTIBIOTIK INFEKSI NOSOKOMIAL YANG DISEBABKAN OLEH Pseudomonas aeruginosa." Jurnal Ilmu Kedokteran dan Kesehatan 6, no. 3 (2019): 242–46. http://dx.doi.org/10.33024/jikk.v6i3.2211.

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Infeksi nosokomial saat ini merupakan salah satu penyebab meningkatnya angka kesakitan (morbiditas) dan angka kematian (mortalitas) di rumah sakit. Infeksi nosokomial banyak disebabkan oleh bakteri Pseudomonas aeruginosa. Pemberian antibiotik menjadi salah satu terapi dalam menyembuhkan infeksi yang disebabkan oleh P. aeruginosa. Namun, apabila pemberian antibiotik tidak dilakukan secara rasional dapat menimbulkan resistensi. Oleh karena itu pengobatan alternatif dengan menggunakan tanaman herbal banyak digunakan pada saat ini. Daun afrika (Vernonia amygdalina) telah dikenal oleh masyarakat Ni

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Bihonegn, Temesgen, Mirutse Giday, Getnet Yimer, Abebe Animut, and Mekonnen Sisay. "Antimalarial activity of hydromethanolic extract and its solvent fractions of Vernonia amygdalina leaves in mice infected with Plasmodium berghei." SAGE Open Medicine 7 (January 2019): 205031211984976. http://dx.doi.org/10.1177/2050312119849766.

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Background: Vernonia amygdalina Del. (Asteraceae) is reported to be traditionally used for the treatment of malaria. Based on folkloric repute of this plant in Ethiopian traditional medicine and crude extract-based ethnopharmacological studies conducted in few countries, this study was undertaken to evaluate the in vivo antimalarial activity of 80% methanol extract and its solvent fractions of the leaves of V. amygdalina in mice infected with Plasmodium berghei. Methods: A 4-day suppressive test was conducted on mice infected with P. berghei to find out antimalarial effect of chloroform, butan

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Ikechi–Nwogu, G. C., S. E. Okere, and N. R. Elendu. "Effectiveness of some plant leaves in the preservation Habanero pepper (Capsicum chinense)." Journal of Applied Sciences and Environmental Management 26, no. 1 (2022): 47–50. http://dx.doi.org/10.4314/jasem.v26i1.7.

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The effectiveness of Persea americana (Avocado), Musa sapientum (Plantain), Veronia amygdalina (Bitter leaf), Colocasia esculenta (Cocoyam) and Carica papaya (Pawpaw) leaves were compared in the preservation of habanero pepper (Caspicum chinense) against storage rot for a period of six weeks. Habanero pepper are tender and have high water content which makes them enormously perishable and susceptible to fungal attack thereby making storage a problem. Habanero pepper was wrapped in surface sterilized leaves of the above-mention plants and control was kept in a different basket without leaves. A

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Agu, Augustine, Patience Orji, Samuel Chime, Kelechi Duru, and Vivian Nwannadi. "Protective effect of aqueous leaf extract of vernonia amygdalina (bitter leaf) on gentamicin induced nephrotoxicity in adult wistar rat." Journal of Medical pharmaceutical and allied sciences 12, no. 3 (2023): 5790–95. http://dx.doi.org/10.55522/jmpas.v12i3.4662.

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This study evaluated the protective effect of an aqueous leaf extract of Vernonia amygdalina on the kidney functions and histological architecture of gentamicin-induced nephrotoxicity in adult Wistar rats. Twenty-five (25) Wistar rats were divided into five groups (groups 1–5), with five rats in each group. Group 1 served as the normal control. Group 2 was the negative control and received 40 mg/kg of body weight of gentamicin. Groups 3, 4, and 5 received an aqueous extract of V. amygdalina at doses of 100 mg, 200 mg, and 400 mg/kg of body weight, respectively, for 21 days. The gentamicin was

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Amushie, Ifeanyi, and O.A. T. Ebuehi. "Therapeutic Effect of Vernonia Amygdalina Aqueous Leaf Extract on Salmonella Typhimurium-Infected Female Wistar Rats." International Journal Of Pharmaceutical And Bio-Medical Science 02, no. 07 (2022): 211–22. https://doi.org/10.5281/zenodo.6881667.

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This study investigated the therapeutic effects of Vernonia amygdalina aqueous leaf extract administration on Salmonella typhimurium infected Wistar rats. Rats were infected orally by a single dose administration of Salmonella typhimurium (1.5 x 10<sup>8</sup> CFU). Negative control groups were infected and treated orally with vehicle (distilled water), neutral control group were not infected, while the four test groups were treated up to 24 days with 50 mg/kg. 100 mg/kg, 150 mg/kg and 200 mg/kg body weight of aqueous leaf extract of V. amygdalina respectively.  The effects of leaf extrac

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Raji, Modinat, Florence Kemi Amoo, Kamoru Abdulazeez Adeniyi, et al. "ANTIBACTERIAL ACTIVITY OF BITTER LEAF (Vernonia amygdalina) EXTRACTS ON Escherichia coli AND Staphylococcus aureus." FUDMA JOURNAL OF SCIENCES 9, no. 4 (2025): 155–60. https://doi.org/10.33003/fjs-2025-0904-3344.

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In recent years, there has been a growing global health concern, necessitating the search for potent, resistance-free medicinal plants with antibacterial properties. This study evaluates the phytochemical and antibacterial properties of Vernonia amygdalina (bitter leaf) extracts as an alternative treatment for bacterial infections. Ethanolic and aqueous extracts of V. amygdalina leaves were prepared and subjected to phytochemical screening, revealing the presence of quinones, tannins, steroids, saponins, terpenoids, alkaloids, phenols, and flavonoids. The antibacterial activity was assessed ag

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Ogunjinmi, Oluwasayo Esther, Olumayowa Vincent Oriyomi, and Adedoyin Adetutu Olasunkanmi. "Phytochemical, Antioxidant and Anti-diabetic Potentials of the Ethanol Leave Extracts of four Medicinal Plants." European Journal of Medicinal Plants 34, no. 5 (2023): 1–11. http://dx.doi.org/10.9734/ejmp/2023/v34i51135.

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For many years, medicinal plants have been a resource for healing in several local communities around the world and the phytochemicals in them such as flavonoids, alkaloids, phenolic, tannins, and terpenoids are attributed to their many medicinal values. Vernonia amydalina, Senna alata, Jatropha curcas, and Grewia pubescens are important plants with immense value. In this study, phytochemical screening, antioxidant analysis and the potential anti-hyperglycemic properties of the plants was investigated in-vitro. The ethanol leave extracts of the plants were subjected to qualitative phytochemica

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Bakpo, Awèdéou, Agbekonyi Kokou Agbodan, Kwami Lumo Awaga, Cynthia Adjo Kouakou, Eyawèdeou Yelegue, and Koffi Jondo. "Improvement of the Quality of the Local Beer «Tchukoutou» by Addition of Two Antioxidant Plants: Ocimum Gratissimum and Vernonia Amygdalina." Oriental Journal Of Chemistry 37, no. 5 (2021): 1068–76. http://dx.doi.org/10.13005/ojc/370508.

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Tchoukoutou are the most widely consumed alcoholic beverages in Africa. However, several constraints undermine this sector of activity. The overall objective of this study is to improve the quality and stability of “Tchoukoutou” by adding leaves of Ocimum gratissimum and Vernonia amygdalina. Two methods of evaluating the alcoholic degree: densimetry and refractometry were used to find the physic and chemical characteristics. From the results obtained, it appears that the red sorghum (Kadag) gives the best organoleptic quality of beers. The addition of the leaves of O. gratissimum and V. amygda

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Ogunbinu, Akinola O., Guido Flamini, Pier L. Cioni, Isiaka A. Ogunwande, and Sunday O. Okeniyi. "Essential Oil Constituents of Eclipta Prostrata (L.) L. and Vernonia amygdalina Delile." Natural Product Communications 4, no. 3 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400321.

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The chemical composition of the essential oils from the leaves and stem bark of Eclipta prostrata (L.) L. and the aerial parts of Vernonia amygdalina Delile (Asteraceae) have been analyzed by capillary gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The investigation led to the identification of 33 and 30 compounds in the oils of the leaves and stem of E. prostrate, respectively, and 40 compounds in the oil of V. amygdalina. While the oil of the leaves of E. prostrata was highly dominated by sesquiterpenoids (89.3%), the stem bark was comprised of sesquiteprenoids (47

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Oluwajobi, Iyanuloluwa, Adamu Yusuf Kabiru, and Ali Audu Jigam. "Flavonoids extracts from Psidium guajava, Vernonia amygdalina, and Azadiracta indica exhibited synergetic inhibitory activities against some food spoilage microorganisms." AROC in Food and Nutrition 1, no. 1 (2021): 15–21. http://dx.doi.org/10.53858/arocfn01011521.

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Background: Flavonoids from medicinal plants have been reported to be a possible alternative to synthetic drugs due to their antimicrobial activities. In the present study, flavonoids extracts from the leaves of Psidium guajava, Vernonia amygdalina, and Azadiracta indica were evaluated for antibacterial and anti-fungi activities against some microbial isolates from spoiled tomato fruit. Methodology: Food spoilage microorganisms were isolated from spoiled tomato fruit. Flavonoids were isolated from the leaves of P. guajava, V. amygdalina, and A. indica, and were evaluated for their inhibitory a

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Farbinah, Channya, Zakari Bawa, Chimbekwujo Ishaku, and Talba Usman. "Control of Ear Rot Fungal Disease of Maize (Zea mays L.) Caused by Fusarium graminearum Using Plant Extracts." AROC in Natural Products Research 03, no. 01 (2023): 01–07. http://dx.doi.org/10.53858/arocnpr03010107.

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Background: This study investigated fungal ear rot disease of maize caused by Fusarium graminearum in Southern Borno state Nigeria. Methods: Aqueous extracts of waltheria (W indica), sickle pod (S. tora) and bitter leaf (Vernonia amygdalina) root, stem, leaf, seed and flower were tested for their efficacy in controlling ear rot fungal pathogen of maize. Completely randomized design (CRD) with three replications protocol was used. Results: The results obtained revealed that the three plant extracts studied, all were found to have inhibitory effect on conidial growth of F. graminearum. The V, am

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