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Journal articles on the topic 'V-CAD'

Author: Grafiati

Published: 3 June 2025

Last updated: 13 July 2025

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MASUDA, Takatoshi, Toshio NAGASHIMA, and Noboru IMAI. "616 Development of a prototype CAE system using V-CAD Framework." Proceedings of The Computational Mechanics Conference 2005.18 (2005): 299–300. http://dx.doi.org/10.1299/jsmecmd.2005.18.299.

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Walker, Ian. "A Smalltalk/V VLSI CAD application." Computer-Aided Engineering Journal 8, no. 2 (1991): 47. http://dx.doi.org/10.1049/cae.1991.0011.

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Jia, Lixin, Jingyao Fan, Wei Cui, et al. "Endothelial Cell-Derived Microparticles from Patients with Obstructive Sleep Apnea Hypoxia Syndrome and Coronary Artery Disease Increase Aortic Endothelial Cell Dysfunction." Cellular Physiology and Biochemistry 43, no. 6 (2017): 2562–70. http://dx.doi.org/10.1159/000484508.

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Background/Aims: Obstructive sleep apnea hypoxia syndrome (OSAHS) is an independent risk factor for coronary artery disease (CAD). Treatment of OSAHS improves clinical outcome in some CAD patients, but the relationship between OSAHS and CAD is complex. Microparticles (MPs) are shed by the plasma membrane by either physiologic or pathologic stimulation. In the current study, we investigated the role of MPs in the context of OSAHS. Methods and Results: 54 patients with both suspected coronary artery stenosis and OSAHS were recruited and underwent both coronary arteriography and polysomnography. Circulating MPs were isolated and analyzed by flow cytometry. CAD+OSAHS patients exhibited greater levels of total MPs (Annexin V+), erythrocyte-derived MPs (CD235+ Annexin V+), platelet-derived MPs (CD41+ Annexin V+), and leukocyte-derived MPs (CD45+ Annexin V+) compared to CAD alone patients or control. CAD+OSAHS patients expressed the greatest level of endothelial-derived MPs of all cellular origin types (CD144+ Annexin V +). Treatment of human aortic endothelial cells (HAECs) with MPs isolated from CAD+OSAHS patients markedly increased HAEC permeability (as detected by FITC-dextran), and significantly upregulated mRNA levels of ICAM-1, VCAM-1, and MCP-1. Conclusion: OSAHS+CAD patients harbor increased levels of MPs, particularly the endothelial cell-derived subtype. When administered to HAECs, OSAHS+CAD patients MPs increase endothelial cell permeability and dysfunction.

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SOTÁK, Vladimír, Martin KUNÍK, and Robert SOTÁK. "THEORA AND PRACTICE IN THE AREA OF TEACHING AND DEPLOYMENT OF CAD/CAM SYSTEMS." Journal of Technology and Information 3, no. 1 (2011): 49–54. http://dx.doi.org/10.5507/jtie.2011.009.

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Girelli, Domenico, Simonetta Friso, Elisabetta Trabetti, et al. "Methylenetetrahydrofolate Reductase C677T Mutation, Plasma Homocysteine, and Folate in Subjects From Northern Italy With or Without Angiographically Documented Severe Coronary Atherosclerotic Disease: Evidence for an Important Genetic-Environmental Interaction." Blood 91, no. 11 (1998): 4158–63. http://dx.doi.org/10.1182/blood.v91.11.4158.

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Abstract Moderate elevation of plasma total homocysteine (tHcy) is a strong and independent risk factor for coronary artery disease (CAD). It can result from genetic or nutrient-related disturbances in the transsulfuration or remethylation pathways for Hcy metabolism. A point mutation (C677T; Ala-to-Val) in the gene encoding the 5,10-methylenetetrahydrofolate reductase (MTHFR) has been recently reported to render the enzyme thermolabile and less active. Studies on the role of this mutation as a risk factor for CAD have given conflicting results. We studied a total of 415 subjects, 278 with angiographically documented multivessel CAD and 137 with angiographically documented normal coronary arteries. The overall frequency of the MTHFR V/V homozygous genotype was 15.7% (with 52.5% heterozygous and 31.8% normal). Subgroup analysis showed no significant differences between CAD and CAD-free subjects. A genotype/phenotype correlation study showed a marked effect of folate on the association between MTHFR genotypes and tHcy. Among individuals with folate levels below the median (11.5 nmol/L), fasting tHcy was significantly increased not only in V/V homozygotes (by 59%) but also, at intermediate values, in A/V heterozygotes (by 21% on average). Conversely, the mutation resulted neutral with respect to tHcy levels in subjects with adequate folate levels. We conclude that, in our population, the MTHFR C677T mutation is rather common, but it does not appear to be associated per se to CAD. A genetic-environmental interaction may contribute to the vascular risk by elevating tHcy when folate status is low.

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Moderate elevation of plasma total homocysteine (tHcy) is a strong and independent risk factor for coronary artery disease (CAD). It can result from genetic or nutrient-related disturbances in the transsulfuration or remethylation pathways for Hcy metabolism. A point mutation (C677T; Ala-to-Val) in the gene encoding the 5,10-methylenetetrahydrofolate reductase (MTHFR) has been recently reported to render the enzyme thermolabile and less active. Studies on the role of this mutation as a risk factor for CAD have given conflicting results. We studied a total of 415 subjects, 278 with angiographically documented multivessel CAD and 137 with angiographically documented normal coronary arteries. The overall frequency of the MTHFR V/V homozygous genotype was 15.7% (with 52.5% heterozygous and 31.8% normal). Subgroup analysis showed no significant differences between CAD and CAD-free subjects. A genotype/phenotype correlation study showed a marked effect of folate on the association between MTHFR genotypes and tHcy. Among individuals with folate levels below the median (11.5 nmol/L), fasting tHcy was significantly increased not only in V/V homozygotes (by 59%) but also, at intermediate values, in A/V heterozygotes (by 21% on average). Conversely, the mutation resulted neutral with respect to tHcy levels in subjects with adequate folate levels. We conclude that, in our population, the MTHFR C677T mutation is rather common, but it does not appear to be associated per se to CAD. A genetic-environmental interaction may contribute to the vascular risk by elevating tHcy when folate status is low.

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Vargas-Alarcón, Gilberto, Carlos Posadas-Romero, Teresa Villarreal-Molina, et al. "The (G>A) rs11573191 Polymorphism ofPLA2G5Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study." BioMed Research International 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/931361.

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Coronary artery disease (CAD) is a multifactorial disorder that results from an excessive inflammatory response. Secretory phospholipase A2-V (sPLA2-V) encoded byPLA2G5gene promotes diverse proinflammatory processes. The aim of the present study was to analyze ifPLA2G5gene polymorphisms are associated with premature CAD. ThreePLA2G5polymorphisms (rs11573187, rs2148911, and rs11573191) were analyzed in 707 patients with premature CAD and 749 healthy controls. Haplotypes were constructed after linkage disequilibrium analysis. Under dominant, recessive, and additive models, the rs11573191 polymorphism was associated with increased risk of premature CAD (OR = 1.51,Pdom= 3.5 × 10−3; OR = 2.95,Prec= 0.023; OR = 1.51,Padd= 1.2 × 10−3). According to the informatics software, this polymorphism had a functional effect modifying the affinity of the sequence by the MZF1 transcription factor.PLA2G5polymorphisms were in linkage disequilibrium and theCGAhaplotype was associated with increased risk of premature CAD (OR = 1.49,P= 0.0023) and with hypertension in these patients (OR = 1.75,P= 0.0072). Our results demonstrate the association of thePLA2G5rs11573191 polymorphism with premature CAD. In our study, it was possible to distinguish one haplotype associated with increased risk of premature CAD and hypertension.

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Liu, Yong Mei, and Hee Kyung Jang. "A Study on the Functional Characteristics of Apparel 3D CAD System." Advanced Materials Research 627 (December 2012): 501–5. http://dx.doi.org/10.4028/www.scientific.net/amr.627.501.

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The purpose of this study was to provide the reference information for current and potential users of apparel 3D CAD system by studying the functional characteristics of apparel 3D CAD study. The apparel 3D CAD system of Optitex, V-Stitcher and DC-Suite was selected for technical compara tive study.The results were at follows: 1. Three systems are similar in basic 3D system configuration and working flow. 2. In configuring a module, Optitex and V-Stitcher separate a 2D pattern and a 3D simulation, whereas DC-Suite configures a 2D pattern and a 3D simulation in one system. 3. In Optitex, a 3D Runway system performs 3D simulation works linked with its own 2D pattern - making software, Optitex PDS, after the 2D pattern is made. 4. In case of V-Stitcher, 2D pattern making is done linked with Gerber Pattern CAD and a 3D simulation proceeds. 5. DC-Suite was developed based on 3D simulation technologies, different from other systems. It includes its own 2D pattern-making technologies.

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NIIYAMA, Kenji, Yoshikazu ISHIHARA, Toshio NAGASHIMA, and Akitake MAKINOUCHI. "359 Interface between voxel-type X-FEM and V-CAD." Proceedings of The Computational Mechanics Conference 2001.14 (2001): 381–82. http://dx.doi.org/10.1299/jsmecmd.2001.14.381.

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Lin, Wei Min, Hitoshi Ohmori, T. Suzuki, Yoshihiro Uehara, Y. Watanabe, and Shinya MORITA. "Characteristics of Free Form Finishing Applying V-CAM System." Key Engineering Materials 329 (January 2007): 273–78. http://dx.doi.org/10.4028/www.scientific.net/kem.329.273.

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A new CAD system, which is called Volume-CAD (VCAD) have been developed. We carried out research and development of VCAD fabrication process based on VCAD/CAM precision control. In this study, a developed V-CAM had been used for a polishing fundamental experiment of a free form surface. The relationship between NC resolution and form accuracy of polished surface are discussed.

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Churchill-Baird, Jonas, Remus Tutunea-Fatan, and Evgueni Bordatchev. "CAD Framework for Parametric Design of V-Groove-Based Functional Surfaces." Computer-Aided Design and Applications 19, no. 6 (2022): 1109–16. http://dx.doi.org/10.14733/cadaps.2022.1109-1116.

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NIIYAMA, Kenji, Yoshikazu ISHIHARA, Toshio NAGASHIMA, Tomonori YAMADA, and Akitake MAKINOUCHI. "Development of X-FEM Analysis System using V-CAD Data Structure." Proceedings of The Computational Mechanics Conference 2002.15 (2002): 349–50. http://dx.doi.org/10.1299/jsmecmd.2002.15.349.

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Del Mar Rojas-Molina, María, Diego Rubiales, Elena Prats, and Josefina Carmen Sillero. "Effects of Phenylpropanoid and Energetic Metabolism Inhibition on Faba Bean Resistance Mechanisms to Rust." Phytopathology® 97, no. 1 (2007): 60–65. http://dx.doi.org/10.1094/phyto-97-0060.

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Effects on penetration and hypersensitive resistance of the cinnamyl acid dehydrogenase (CAD) suicide inhibitor ([(2-hydroxyphenyl) amino] sulphinyl) acetic acid, 1.1 dimethyl ester, which suppresses phenylpro-panoid biosynthesis, and of D-mannose, which sequesters phosphate and reduces energy available in host cells, were studied in faba bean (Vicia faba) genotypes with differing resistance mechanisms to faba bean rust (Uromyces viciae-fabae). Inhibition of CAD reduced penetration resistance in lines 2N-34, 2N-52, V-1271, and V-1272, revealing an important role for phenylpropanoid biosynthesis in the resistance of these lines. Inhibition of CAD also inhibited hypersensitive cell death in these lines. D-mannose had little or no effect on resistance. By contrast, CAD inhibition did not affect penetration resistance of line BPL-261, which has a high degree of penetration resistance not associated with hypersensitive cell death. In BPL-261, D-mannose inhibited penetration resistance. The parallelism between the faba bean genotype responses to rust observed here and the response of barley genotypes with differing resistance mechanisms to powdery mildew after similar inhibitor treatments is analyzed and discussed.

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Tatarinova, A. A., D. V. Svalov, and K. Y. Lukianets. "Is it possible to determine arrhythmogenic focus localization of ventricular ectopic complexes detected by ambulatory electrocardiogram monitoring?" Medical alphabet 1, no. 7 (2023): 27–33. http://dx.doi.org/10.33667/2078-5631-2023-7-27-33.

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Aim. To study the possibility of using algorithms (developed using resting ECG as a mapping tool) for localization arrhythmogenic focus of ventricular arrhythmias (VA) detected by ambulatory 12-lead ECG monitoring (AECGM) with the identification of predominant origins of VA.Material and methods. The study included 54 patients aged 45 to 80 years with high frequency VA evaluated during AECGM: 29 — with coronary artery disease (CAD), 25 — w ithout CAD, who underwent radiofrequency ablation (RFA). The study included patients with effective ablation based on AECGM performed 6 months after RFA. Verification localization of VA exit site was carried out during endocardial mapping and AECGM («Cardiotechnika-04, СT-07», «Incart»). The following algorithms were considered in the study: D. Kuchar; O. Segal; J. Miller; A. S. Revishvili, R. Y. Snegur (2006, 2007); A. B. Weinstein; M. V. Noskova. It was assessed the percentage of matches applying the comparative analysis of results of the invasive and non-invasive methods, and it was revealed the predominant localization of VA.Results. The following algorithms had the highest percentage of matches: D. Kuchar in patients with CAD; A. S. Revishvili, R. Y. Snegur (2007) and M. V. Noskova in patients without CAD. The predominant origins of VA in patients without CAD were the left sinus of Valsalva, right ventricular outflow tract, and in patients with CAD — b asal inferior left ventricular wall, right ventricular outflow tract.Conclusion. Algorithms for arrhythmogenic focus localization of VA, developed using resting ECG, can be used to determine the origin of VA detecting by 12-lead AECGM, taking into account patient’s medical history (CAD, myocardial infarction).

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Yuniarti, Novi, Retno Andri Pramudyarini, Ang Cheche, and Eva Zulva Ivana. "PENERAPAN TEKNOLOGI DIGITAL PADA TEKNIK PECAH POLA FASHION DESAIN." JSRW (Jurnal Senirupa Warna) 11, no. 2 (2023): 121–41. http://dx.doi.org/10.36806/jsrw.v11i2.188.

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Laporan Penelitian ini dibuat bertujuan untuk mengembangkan metode pembelajaran sistem digital Softwear CAD Richpeach v.8 pada mata kuliah pengembangan pola dan penelitian ini merupakan jenis penelitian R&D (Research & Development) dengan model pengembangan Borg & Gall yang dikutip dalam tim Pusat Penelitian kebijakan dan Inovasi (Puslijaknov). Pengumpul data menggunakan angket dengan skala Guttman untuk para ahli dan skala Likert, lembar observasi, dan lembar wawancara.Teknik analisis data yang digunakan adalah analisis statistik deskriptif kualitatif dan kuantitatif. Hasil penelitian adalah 1)Multimedia tutorial pembuatan materi mata kuliah pengembangan pola dengan sistem digital CAD reacpeach v.8 untuk mahasiswa Desain produk mode dan busana FSRIKJ berhasil dikembangkan melalui penelitian R&D dengan model pengembangan Borg & Gall yang dikutip dalam tim Puslitjaknov; 2) Multimedia tutorial pembuatan materi pengembangan pola sistem digital softwear CAD Richpeace digital dinyatakan layak oleh ahli media dan ahli materi, simpulan agar dapat mengembangkan standar kompetensi, agar kegiatan belajar mengajar pada mata kuliah pengembangan pola dapat lebih menarik dan memotivasi mahasiswa.

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Moinpour, Carol, Donna Lynn Berry, Benjamin Ely, et al. "Preliminary quality-of-life outcomes for SWOG-9346: Intermittent androgen deprivation in patients with hormone-sensitive metastatic prostate cancer (HSM1PC)—Phase III." Journal of Clinical Oncology 30, no. 15_suppl (2012): 4571. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.4571.

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4571 Background: The relative quality of life (QOL) for patients with newly diagnosed, metastatic prostate cancer, treated with intermittent androgen deprivation (IAD) has been assumed and hypothesized, yet never compared in a well-powered randomized trial (RT) to continuous androgen deprivation (CAD). SWOG-9346 provided such a RT in which to test QOL differences between CAD and IAD in men with metastatic prostate cancer. Methods: Patients were randomized to CAD or IAD. Patients completed the SWOG QOL Questionnaire (SF-20/SF-36, Symptom Distress Scale, treatment-specific symptoms, global QOL) at randomization and months (mo) 3, 9, and 15 post-randomization. Five QOL change scores at one time point (mo 3) were designated as primary for the QOL endpoint and are reported in this abstract: impotence, libido, energy/vitality (E/V), physical function (PF), and emotional function (EF). Significance level was adjusted for 5 comparisons (used p=0.01). Results: 615 patients in the CAD arm and 633 in the IAD arm completed the QOL questionnaire at baseline. Change between baseline and 3 months differed for the two arms with CAD reporting statistically significantly more impotence and less libido than IAD. EF was also slightly better for the IAD arm. Conclusions: These results indicate better sexual function in men receiving IAD versus CAD through post-randomization month 3. Additional benefits for IAD may include better PF, E/V and EF. Ongoing analyses will address the role of missing data, additional follow-up assessments, and resumption of therapy in the IAD arm. [Table: see text]

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Wang, B. "CAD Applications in a Formula SAE Project Based on V Designing Process." Computer-Aided Design and Applications 8, PACE (2011): 47–65. http://dx.doi.org/10.3722/cadaps.2011.pace.47-65.

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Kaldas, Marco, Anita Radhakrishnan, Victor Farah, Ronald Williams, Richard Lombardi, and Moneal Shah. "Double Trouble: CAD and Lyme Tick Bite the Heart Till V Tac." Journal of Cardiovascular Magnetic Resonance 26 (2024): 100030. http://dx.doi.org/10.1016/j.jocmr.2024.100030.

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Šupler, Marek, Andrej Jenča, Michal Straka, Juraj Deglovič, and Janka Jenčová. "The success rate of indirect adhesive restorations in the distal dentition fabricated with chairside CAD/CAM system." Stomatológ 33, no. 2 (2023): 10–14. http://dx.doi.org/10.69658/sto.2023.010.

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Hsu, Cheng-Hsun, Chun-Yin Lin, and Jian-Xun Chen. "Wear and Corrosion Performance of Ti-6Al-4V Alloy Arc-Coated TiN/CrN Nano-Multilayer Film." Metals 13, no. 5 (2023): 907. http://dx.doi.org/10.3390/met13050907.

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The objective of this study was to investigate the effect of varying bias parameters (−50 V, −100 V, and −150 V) on the properties of TiN/CrN multilayer films deposited on Ti-6Al-4V alloy using the cathodic arc deposition (CAD) technique. The deposited films were characterized for their composition, structure, morphology, thickness, adhesion, and hardness. Wear and polarization tests were also conducted to determine the optimal bias condition for wear and corrosion resistance. The results showed that the TiN/CrN films possessed a nano-multilayered structure comprising TiN and CrN phases. The hard coating significantly increased the surface hardness of Ti-6Al-4V alloy up to three–five times. The coated specimens demonstrated superior wear resistance compared to the uncoated, with the −150 V specimen exhibiting the least wear rate. Furthermore, the −150 V specimen had the highest polarization impedance value, indicating the best corrosion resistance compared to the other bias conditions. In short, the use of CAD-coated TiN/CrN multilayer film enhanced the surface properties of Ti-6Al-4V alloy, with the best wear and corrosion resistance achieved at −150 V bias. These novel findings have significant implications for improving the performance and durability of Ti-6Al-4V alloy components in various industrial applications.

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Sanjay K Gupta, Satish Bansal, Rakesh S. Jadon,. "Breast Tumor Recognition by Semantic Segmentation of Multiclass Ultrasound Images." International Journal on Recent and Innovation Trends in Computing and Communication 11, no. 9 (2023): 938–46. http://dx.doi.org/10.17762/ijritcc.v11i9.8986.

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Objectives: The main purpose of this paper is to suggest a semantic segmentation model to reduce training time in ultrasound breast cancer images. This is achieved by employing a smaller network with fewer trainable parameters, resulting in faster training while maintaining maximum accuracy. Methods: This paper proposes a modified U-Net model, which we call the V model, for the subdivision of breast tumors. The proposed V architecture is applied explicitly to ultrasound breast cancer datasets for semantic segmentation. Our proposed model achieves semantic segmentation by employing an encoder and decoder on real and mask image datasets. Findings: Therefore, developing a proposed system, namely a V-Net computer-aided diagnosis (CAD) system, is imperative. This CAD system aims to minimize human errors while enhancing accuracy and speed in the premature finding of breast tumors. The proposed model utilizes minimal layers and parameters while maintaining superior results regarding correctness, speed, and computational proficiency. Novelty: The proposed V-net model applies to analysing any medical image for detecting disease and finding more accuracy than other U-net models.

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Subathra, K., M. R. Gokula Pandiasankar, D. Kavitha, and R. Shobana. "Morphological Array of Cardiac and Coronary Artery Diseases in Cases of Sudden Death: An Autopsy-Based Histopathological Study in Rural Setup." Journal of Indian Academy of Forensic Medicine 45, no. 1 (2023): 85–90. http://dx.doi.org/10.48165/jiafm.2023.45.1.20.

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Cardiovascular diseases are the foremost cause of sudden death in adults. The primary objective of this study is to estimate the prevalence of various cardiac and coronary artery diseases in sudden unexpected death cases in rural setup. Estimation of age and sex-wise frequency of coronary atherosclerotic disease (CAD), and grading of CAD by applying the Modified American Heart Association (AHA) classification are secondary objectives. In this three years prospective cross-sectional study, heart specimens were studied from 136 persons whose death was sudden and unexpected. Gross dissection and histopathological examination of coronary arteries and heart were done. Diagnoses were based on both gross and microscopic findings. CAD with or without other diseases was the most frequent pathology (n-100, 73.5%). Left ventricular hypertrophy in 45 cases (33.09%), myocardial infarction in 30 cases (22.06%), valvular abnormalities in three cases (2.2%), infective endocarditis in two cases (1.47%), aortic dissection in one case (0.74%), right ventricular hypertrophy in one case (0.74%) and cardiac myocyte atrophy in one case (0.74%) were observed. Male-female ratio of CAD was 8.09:1. Advanced CADs (type IV, V, VI) were found in 94 (94%) cases. In males, the maximum number of advanced CAD was observed in the fifth decade (n- 27, 31.76%) and in females in the seventh decade (n- 4, 44.44%). This study reveals the increasing trend of CAD in rural populations. This study adds rare entities like young-age aortic dissection and cardiac myocyte atrophy to the existing literature and emphasises the importance of autopsy in sudden death cases.

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Hayashi, Yoko, Hiroko Satake, Satoko Ishigaki, et al. "Kinetic volume analysis on dynamic contrast-enhanced MRI of triple-negative breast cancer: associations with survival outcomes." British Journal of Radiology 93, no. 1106 (2020): 20190712. http://dx.doi.org/10.1259/bjr.20190712.

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Objective: To evaluate the associations between computer-aided diagnosis (CAD)-generated kinetic volume parameters and survival in triple-negative breast cancer (TNBC) patients. Methods: 40 patients with TNBC who underwent pre-operative MRI between March 2008 and March 2014 were included. We analyzed CAD-generated parameters on dynamic contrast-enhanced MRI, visual MRI assessment, and histopathological data. Cox proportional hazards models were used to determine associations with survival outcomes. Results: 12 of the 40 (30.0%) patients experienced recurrence and 7 died of breast cancer after a median follow-up of 73.6 months. In multivariate analysis, higher percentage volume (%V) with more than 200% initial enhancement rate correlated with worse disease-specific survival (hazard ratio, 1.12; 95% confidence interval, 1.02–1.22; p-value, 0.014) and higher %V with more than 100% initial enhancement rate followed by persistent curve type at 30% threshold correlated with worse disease-specific survival (hazard ratio, 1.33; 95% confidence interval, 1.10–1.61; p-value, 0.004) and disease-free survival (hazard ratio, 1.27; 95% confidence interval, 1.12–1.43; p-value, 0.000). Conclusion: CAD-generated kinetic volume parameters may correlate with survival in TNBC patients. Further study would be necessary to validate our results on larger cohorts. Advances in knowledge: CAD generated kinetic volume parameters on breast MRI can predict recurrence and survival outcome of patients in TNBC. Varying the enhancement threshold improved the predictive performance of CAD generated kinetic volume parameter.

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Antonescu, Ovidiu. "Metal Pushing V-Belt Continuously Variable Transmissions (CVT) Used in Motor Vehicles." Applied Mechanics and Materials 823 (January 2016): 229–34. http://dx.doi.org/10.4028/www.scientific.net/amm.823.229.

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The paper presents 3D modeling of a trapezoidal element (V-element) of a metal pushing V-belt. This type of belt is used on the Continuously Variable Transmissions (CVT) with friction pulleys that equip low and medium capacity motor vehicles. Also, the structural analysis of the V-belt element with regards to the material strength is presented. Modeling and simulation have been accomplished by an advanced CAD – CAM – CAE software which permits three-dimensional virtual design of the V-element or the entire belt.

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Suellen Pinheiro, Carvalho Valverde, Alexandre Yahouédéhou Setondji Cocou Modeste, Mota de Oliveira Rodrigo, et al. "HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women." Open Journal of Pain Medicine 6, no. 1 (2022): 012–18. http://dx.doi.org/10.17352/ojpm.000029.

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Reports describe the association between platelet activation, adhesion, and aggregation, as well as polymorphisms in genes encoding platelet membrane glycoproteins with a predisposition to coronary artery disease (CAD). This study investigates associations between HPA-1, -3 and C807T polymorphisms and CAD. A cross-sectional study involving 114 women who underwent coronary angiography was performed. The CAD+ group consisted of 63 women while the CAD- group of 51 women. Hematological and biochemical parameters were evaluated by electronic methods. Polymorphisms were investigated by PCR-RFLP and PCR-SSP and participants answered an epidemiological questionnaire and provided anthropometric data. Blood pressure was also measured. Statistical analyses were performed using EpiInfo v. 7.0 software. Results showed that age, diabetes mellitus, hypertension, and hyperlipidemia were associated with CAD. In addition, CAD+ women showed elevated glucose, TG, and VLDL-c levels and reduced HDL-c levels. No significant difference was observed between the allelic and genotypic distributions of the polymorphisms HPA-1, -3, and C807T in CAD+ and CAD- groups. However, CAD+ women carriers of the variant 3b allele had elevated TG and sP-selectin levels while the carriers of the variant 807T allele had reduced CT and LDL-c levels. Hence, our data suggest that the polymorphism HPA-3 increases, indirectly, the risk of CAD development and occurrence while polymorphism C807T reduces this effec.

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Rouvière, Olivier, Rémi Souchon, Carole Lartizien, et al. "Detection of ISUP ≥2 prostate cancers using multiparametric MRI: prospective multicentre assessment of the non-inferiority of an artificial intelligence system as compared to the PI-RADS V.2.1 score (CHANGE study)." BMJ Open 12, no. 2 (2022): e051274. http://dx.doi.org/10.1136/bmjopen-2021-051274.

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IntroductionProstate multiparametric MRI (mpMRI) has shown good sensitivity in detecting cancers with an International Society of Urological Pathology (ISUP) grade of ≥2. However, it lacks specificity, and its inter-reader reproducibility remains moderate. Biomarkers, such as the Prostate Health Index (PHI), may help select patients for prostate biopsy. Computer-aided diagnosis/detection (CAD) systems may also improve mpMRI interpretation. Different prototypes of CAD systems are currently developed under the Recherche Hospitalo-Universitaire en Santé / Personalized Focused Ultrasound Surgery of Localized Prostate Cancer (RHU PERFUSE) research programme, tackling challenging issues such as robustness across imaging protocols and magnetic resonance (MR) vendors, and ability to characterise cancer aggressiveness. The study primary objective is to evaluate the non-inferiority of the area under the receiver operating characteristic curve of the final CAD system as compared with the Prostate Imaging-Reporting and Data System V.2.1 (PI-RADS V.2.1) in predicting the presence of ISUP ≥2 prostate cancer in patients undergoing prostate biopsy.MethodsThis prospective, multicentre, non-inferiority trial will include 420 men with suspected prostate cancer, a prostate-specific antigen level of ≤30 ng/mL and a clinical stage ≤T2 c. Included men will undergo prostate mpMRI that will be interpreted using the PI-RADS V.2.1 score. Then, they will undergo systematic and targeted biopsy. PHI will be assessed before biopsy. At the end of patient inclusion, MR images will be assessed by the final version of the CAD system developed under the RHU PERFUSE programme. Key secondary outcomes include the prediction of ISUP grade ≥2 prostate cancer during a 3-year follow-up, and the number of biopsy procedures saved and ISUP grade ≥2 cancers missed by several diagnostic pathways combining PHI and MRI findings.Ethics and disseminationEthical approval was obtained from the Comité de Protection des Personnes Nord Ouest III (ID-RCB: 2020-A02785-34). After publication of the results, access to MR images will be possible for testing other CAD systems.Trial registration numberNCT04732156.

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Tanmay Ghosh, Khan Alamgir, Yang Xingyao, Muhammad Fayaz,. "Computer-Aided Diagnostic System for Digital Mammography." INFORMATION TECHNOLOGY IN INDUSTRY 9, no. 2 (2021): 989–95. http://dx.doi.org/10.17762/itii.v9i2.443.

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In this work, Computer-Aided Detection (CADe) and Computer-Aided Diagnosis (CADx) systems are developed and tested using the public and freely available mammographic databases named MIAS and DDSM databases, respectively. CADe system is used to differentiate between normal and abnormal tissues, and it assists radiologists to avoid missing a breast abnormality. At the same time, CADx is developed to distinguish between normal, benign and malignant breast tissues, and it helps radiologists to decide whether a biopsy is needed when reading a diagnostic mammogram or not. Any CAD system is constituted of typical stages including preprocessing and segmentation of mammogram images, extraction of regions of interest (ROI), features removal, features selection and classification. In both proposed CAD systems, ROIs are selected using a window size of 32×32 pixels, then a total of 543 features from four different feature categories are extracted from each ROI and then normalized. After that, the selection of the most relevant features is performed using four different selection methods from MATLAB Pattern Recognition Toolbox v.5 (PRtool5) named Sequential Backward Selection (SBS), Sequential Forward Selection (SFS), Sequential Floating Forward Selection (SFFS) and Branch and Bound Selection (BBS) methods. We also utilized Principal Component Analysis (PCA) as the fifth method to reduce the dimensions of the features set. After that, we used different classifiers such as Support Vector Machines (SVM), K-voting Nearest Neighbor (K-NN), Quadratic Discriminant Analysis (QDA) and Artificial Neural Networks (ANN) for the classification. Both CAD systems have the same implementation stages but different output. CADe systems are designed to detect breast abnormalities while CADx system indicates the likelihood of malignancy of lesions. Finally, we independently compared the performance of all classifiers with each selection method in both modes. The evaluation of the proposed CAD systems is done using performance indices such as sensitivity, specificity, the area under the curve (AUC) of the Receiver Operating Characteristic (ROC) curves, the overall accuracy and Cohen-k factor. Both CAD systems provided encouraging results. These results were different corresponding to the selection method and classifier.

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Jo, Jang-Hoon, and Hun Oh. "Development of Motor for 11,000[V] Class Electrical Submersible Pump using Motor cad." Transactions of The Korean Institute of Electrical Engineers 72, no. 2 (2023): 288–94. http://dx.doi.org/10.5370/kiee.2023.72.2.288.

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Rmandić, Milena, Miloš Rađenović, Jovana Stanković, Ana Protić, Biljana Otašević, and Anđelija Malenović. "PDA-CAD method for the determination of magnesium, pyridoxine and thiamine in a dietary supplement supported by analytical quality by design methodology." Arhiv za farmaciju 71, no. 5 (2021): 378–92. http://dx.doi.org/10.5937/arhfarm71-32093.

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In this research, Analytical Quality by Design (AQbD) methodology was used to develop the HILIC-PDA-CAD method for the determination of magnesium, pyridoxine and thiamine content in a dietary supplement. Experiments were conducted on the Dionex Ulitimate 3000 HPLC system with PDA and CAD detectors. Separations were performed on the ZIC-HILIC PEEK column (100 × 4.6 mm, 5 mm) with a mixture of acetonitrile, acetone and ammonium acetate/ammonium formate aqueous solution (48:12:40, v/v/v) as the mobile phase. The detection was performed at 220 nm. The optimal settings of CAD were defined with the one-factor-at-a-time approach: evaporation temperature 50°C, filter constant 10 s, pressure gas 60 psi. The influence of qualitative (salt type) and quantitative factors (pH and salt concentration) on the magnesium retention factor, k Mg and the selectivity factor between pyridoxine and chloride anion, a B6/Cl-, was tested using the I-optimal design. The design space was defined by Monte Carlo simulations and model coefficients' errors were propagated with the aim of identifying the conditions that meet the following criteria: k Mg <4 and a B6/Cl->3.5, with the probability p=95%. From the derived 2D-Design Space graph, 95 mM of ammonium formate pH 4.4 was selected as the optimal composition of the aqueous phase. The method was validated and its reliability in routine application was confirmed.

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Hampe, R., B. Theelke, N. Lümkemann, M. Eichberger, and B. Stawarczyk. "Fracture Toughness Analysis of Ceramic and Resin Composite CAD/CAM Material." Operative Dentistry 44, no. 4 (2019): E190—E201. http://dx.doi.org/10.2341/18-161-l.

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SUMMARY Objectives: To evaluate and compare the fracture toughness of dental CAD/CAM materials of different material classes intended for in-office milling (glass ceramics, hybrid, resin composites) and the influence of aging on this property. Methods and Materials: The fracture toughness (critical intensity factor, KIc) values of 9 CAD/CAM restorative materials (Ambarino High-Class, Brilliant Crios, Cerasmart, exp. CAD/CAM composite, Katana Avencia, Lava Ultimate, VITA Enamic, IPS Empress CAD, and IPS e.max CAD) were determined using the SEVNB method in a four-point bending setup. Twenty bending bars of each material with a 4 × 3 cross and a minimum length of 12 mm were cut out of CAD/CAM milling blocks. Notching was done starting with a pre-cut and consecutive polishing and v-shaping with a razor blade, resulting in a final depth of v-shaped notches of between 0.8 and 1.2 mm. Half of the specimens were selected for initial fracture toughness measurements. The others were thermocycled in distilled water for 30,000× (5/55°C; 30-second dwell time) before testing. Specimen fracture surfaces were analyzed using confocal laser scanning microscopy. Results: All specimens for each material fractured into two fragments and showed the typical compression curl and brittle failure markings. Comparing initial KIc values, lithium disilicate ceramic IPS e.max CAD showed significantly the highest and leucite-reinforced ceramic IPS Empress CAD significantly the lowest KIc values (p&lt;0.001). All tested CAD/CAM materials with a resin component ranged in the same KIc value group (p&gt;0.999-0.060). After thermal cycling, the highest KIc values were measured for lithium disilicate ceramic IPS e.max CAD, followed by resin composite materials Ambarino High-Class (p&lt;0.001-0.006) and hybrid material VITA Enamic (p&lt;0.001-0.016), while the significantly lowest values were reflected for the resin composite materials Cerasmart, LAVA Ultimate (p&lt;0.001-0.006), and Katana Avencia (p&lt;0.001-0.009). The roughness of the fracture surfaces varied depending on the microstructure of the respective material. The ceramic surfaces showed the smoothest surfaces. The fracture surface of VITA Enamic revealed microstructural inhomogeneities and microcracks. For CAD/CAM resin composite materials, crack paths through the matrix and interfaces of matrix and fillers could be observed at the microstructure level. Conclusions: The materials tested show differences in fracture toughness typical for the class they belong to. With one exception (Ambarino High-Class), thermocycling affected the fracture toughness of materials with a resin component negatively, whereas the leucite and lithium disilicate ceramic showed stability.

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Adam, Luise, Eva Strickler, Meisam K. Borozadi, et al. "Prognostic Role of Polyvascular Involvement in Patients with Symptomatic Peripheral Artery Disease." Journal of Clinical Medicine 12, no. 10 (2023): 3410. http://dx.doi.org/10.3390/jcm12103410.

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Background: Statin therapy is recommended for patients with peripheral artery disease (PAD). However, PAD patients with polyvascular (PV) extent remain threatened by an increased residual cardiovascular (CV) risk. Purpose: To investigate the association of prescribed statin therapy and mortality in PAD patients with or without PV extent. Methods: A single-center retrospective longitudinal observational study originating from a consecutive registry with 1380 symptomatic PAD patients over a mean observational time of 60 ± 32 months. The association of atherosclerotic extent and statin use (PAD, plus one additional region (CAD or CeVD, [+1 V]), +2 vascular regions (+CAD and CeVD [+2 V]) with the risk of all-cause mortality was evaluated using Cox proportional hazard models adjusted for potential confounding factors. Results: The mean age of the study’s participants was 72.0 ± 11.7 years, with 36% being female. PAD patients with PV extent [+1 V] and [+2 V] were older and suffered from diabetes, hypertension, or dyslipidemia more often; they, too, had more severely impaired kidney function (all p < 0.0001) compared to patients with PAD only. PAD patients with PV [+1 V] and [+2 V] received better statin medication and reached the recommended LDL-C target compared to PAD-only patients (p < 0.001). Despite better statin treatment, the rate of all-cause mortality was higher in PV patients than in PAD-only patients (PAD only: 13%; [+1 V]: 22%; [+2 V]: 35%; p < 0.0001). Conclusion: PV patients receive better statin therapy than PAD-only patients but nevertheless still have higher mortality rates. Future studies are needed to explore whether more aggressive LDL-lowering treatment for PAD patients may be translated into better prognosis.

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Gómez-Coba, Ronald Medardo, Sofia Milena Ortiz-Araque, Nicole Patricia Paredes-Mena, and Rómulo Guillermo López-Torres. "Avances tecnológicos en la planificación de cad-cam en diseño de sonrisa." Revista Arbitrada Interdisciplinaria de Ciencias de la Salud. Salud y Vida 8, no. 1 (2024): 1167–73. https://doi.org/10.35381/s.v.v8i1.3897.

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Objetivo: Analizar los avances tecnológicos en la planificación de CAD-CAM en diseño de sonrisa. Método: Descriptiva documental. Conclusión: Las limas Pro Taper Gold tienen una mejor resistencia a la flexión, ya que, en una comparación de las dos limas, Pro Taper Gold ocupó el primer lugar, seguida de V-Taper Fanta Gold, según sus índices de resistencia y deformación para ambas clases de corte. Pro Taper Gold presenta una mejor capacidad de centrado, sin embargo, tenía una menor extrusión de residuos en comparación con V-Taper Gold. Debido a los escasos estudios sobre las limas V-Taper Gold se recomienda utilizar las limas Pro Taper, ya que estas han sido probadas en varios estudios que garantizan su eficiencia.

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Bertol, Charise Dallazem, Maria Tereza Friedrich, Graciela Carlos, and Pedro Eduardo Froehlich. "Analytical Stability-Indicating Methods for Alogliptin in Tablets by LC–CAD and LC–UV." Journal of AOAC INTERNATIONAL 100, no. 2 (2017): 400–405. http://dx.doi.org/10.5740/jaoacint.16-0183.

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Abstract Stability-indicating LC methods using a UV detector and a charged aerosol detector (CAD) simultaneously were validated for the assessment of alogliptin (ALG) in tablets. The analysis was performed on a C8 column (250 × 4.6 mm, 5 μm) at a flow of 0.8 mL/min, using acetonitrile–10 mM ammonium acetate buffer (pH 3.5; 90 + 10, v/v) as mobile phase and UV detection at 275 nm. Validation followed the International Conference on Harmonization guidelines. The method was linear over the range of 25–200 μg/mL. Normality of the residuals showed a normal distribution, no autocorrelation, and homoscedasticity. LODs were 6.25 and 2.65 µg/mL and LOQs were 20.85 and 8.84 µg/mL for the CAD and the UV detector, respectively. The methods were precise and accurate. Excipients and degradation products did not interfere in the methods in studies of specificity. None of the factors studied in the analysis of robustness had a significanteffect on the quantification of the ALG by the Pareto chart. The results of the assay obtained with LC–CAD and LC–UV were similar. The methods could be considered interchangeable and stability-indicating, and can be applied as an appropriate QC tool for analysis of ALG in tablets.

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Chen, Shao Ke, and Hui Qun Chen. "Triangulation Method of 3D Scattered Data Points Based on CAD Model." Applied Mechanics and Materials 52-54 (March 2011): 139–43. http://dx.doi.org/10.4028/www.scientific.net/amm.52-54.139.

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A new method of triangulation for large scale scattered 3D points is proposed. This method is based on the available CAD model, with the thought of DC(divide and conquer).Alignment between the data and the CAD model, registration which establishes correspondence between the data points and those on the CAD trimmed NURBS surface entities;2D-Delaunay triangulation, performed on the corresponding points in the parametric domains(u, v)of each entity, application of the connectivity structure to the 3D data points for each mesh patch; Elimination of redundant triangles of each 3D mesh patch and stitching of patches together. Unlike many other methods, it is not constrained by certain types of measurement distribution or object shape. The experimental results testify that the approach is feasible and efficient.

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Tichánek, Radek, and Sergii Bogomolov. "DESIGN ASSISTANCE SYSTEM APPLICATIONS FOR SIMULATION OF IC ENGINE DYNAMICS." Journal of Middle European Construction and Design of Cars 11, no. 3 (2013): 9–15. http://dx.doi.org/10.2478/mecdc-2013-0011.

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SHRNUTÍ Design Assistance System (DASY)[1] umožňuje použit přistup, kdy konstrukter/vypočtař potřebuje propojit všechny aspekty navrhu pro dosaženi optimalniho řešeni. Tento članek je zaměřen na prezentaci vybranych vypočetnich metod a jejich integrace do DASY. Metody kombinuji CAD konstrukčni navrhy současti spalovaciho motoru s modely pro vypočet dynamiky klikoveho a rozvodoveho mechanismu. Vypočetni modely jsou řešeny v komerčnim softwaru nebo přimo v DASY. Koncept pro navrhovani zdvihove křivky ventilů je představen jako zastupce metod, ktere mohou byt řešeny přimo v DASY pomoci Gauss-Newtonovy iteračni metody. Vyvinute koncepty mohou byt dale začleneny do modelu celeho motoru nebo vozidla diky blokove struktuře DASY

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Patel, Riyaz S., Spiros Denaxas, Laurence J. Howe, et al. "Reproducible disease phenotyping at scale: Example of coronary artery disease in UK Biobank." PLOS ONE 17, no. 4 (2022): e0264828. http://dx.doi.org/10.1371/journal.pone.0264828.

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Importance A lack of internationally agreed standards for combining available data sources at scale risks inconsistent disease phenotyping limiting research reproducibility. Objective To develop and then evaluate if a rules-based algorithm can identify coronary artery disease (CAD) sub-phenotypes using electronic health records (EHR) and questionnaire data from UK Biobank (UKB). Design Case-control and cohort study. Setting Prospective cohort study of 502K individuals aged 40–69 years recruited between 2006–2010 into the UK Biobank with linked hospitalization and mortality data and genotyping. Participants We included all individuals for phenotyping into 6 predefined CAD phenotypes using hospital admission and procedure codes, mortality records and baseline survey data. Of these, 408,470 unrelated individuals of European descent had a polygenic risk score (PRS) for CAD estimated. Exposure CAD Phenotypes. Main outcomes and measures Association with baseline risk factors, mortality (n = 14,419 over 7.8 years median f/u), and a PRS for CAD. Results The algorithm classified individuals with CAD into prevalent MI (n = 4,900); incident MI (n = 4,621), prevalent CAD without MI (n = 10,910), incident CAD without MI (n = 8,668), prevalent self-reported MI (n = 2,754); prevalent self-reported CAD without MI (n = 5,623), yielding 37,476 individuals with any type of CAD. Risk factors were similar across the six CAD phenotypes, except for fewer men in the self-reported CAD without MI group (46.7% v 70.1% for the overall group). In age- and sex- adjusted survival analyses, mortality was highest following incident MI (HR 6.66, 95% CI 6.07–7.31) and lowest for prevalent self-reported CAD without MI at baseline (HR 1.31, 95% CI 1.15–1.50) compared to disease-free controls. There were similar graded associations across the six phenotypes per SD increase in PRS, with the strongest association for prevalent MI (OR 1.50, 95% CI 1.46–1.55) and the weakest for prevalent self-reported CAD without MI (OR 1.08, 95% CI 1.05–1.12). The algorithm is available in the open phenotype HDR UK phenotype library (https://portal.caliberresearch.org/). Conclusions An algorithmic, EHR-based approach distinguished six phenotypes of CAD with distinct survival and PRS associations, supporting adoption of open approaches to help standardize CAD phenotyping and its wider potential value for reproducible research in other conditions.

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IWASE, Hidehito, Ryutaro HIMENO, Shigeho NODA, and Kazuaki FUKASAKU. "Development of Numerical Simulation System of Hemodynamics Based on V-CAD and VOF-FVM." Proceedings of The Computational Mechanics Conference 2004.17 (2004): 339. http://dx.doi.org/10.1299/jsmecmd.2004.17.339.

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Fronczek, Martyna, Joanna Katarzyna Strzelczyk, Tadeusz Osadnik, Krzysztof Biernacki, and Zofia Ostrowska. "VDR Gene Polymorphisms in Healthy Individuals with Family History of Premature Coronary Artery Disease." Disease Markers 2021 (January 29, 2021): 1–9. http://dx.doi.org/10.1155/2021/8832478.

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Aim. The gene encoding the vitamin D receptor (VDR) is considered in many studies to be a good candidate responsible for susceptibility to several diseases such as coronary artery disease (CAD). Epidemiological data show that cardiovascular disease is one of the major health problems in Polish society. Basic studies show that genetic factors play a significant role in the pathogenesis of CAD. We conducted this clinical study to determine if the VDR gene polymorphisms TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) could predispose healthy individuals to an increased risk of premature CAD (P-CAD) incidents. Methods. We genotyped 845 subjects in a cohort consisting of 386 healthy volunteers with a documented P-CAD incident in their first-degree relatives and 459 healthy volunteers without family history (FH) of P-CAD. TaqI, ApaI, and FokI polymorphisms in VDR were genotyped using TaqMan assays and the endpoint genotyping method (qPCR). Statistical analyses were performed using the Power Analysis Software STATISTICA v.13.3. Results. Although no statistical significance was found for TaqI and ApaI genotype frequencies, the AA genotype of FokI polymorphism was significantly more frequent in the study group compared to the control group (24.61% vs. 16.99%). The results of logistic regression analysis suggested a significant association between FokI polymorphism and FH of P-CAD in heathy people under the recessive model (OR: 1.26 (1.07-1.49, p = 0.007 )); however, the frequency of VDR haplotypes did not differ significantly between the control and study populations. Conclusions. FokI polymorphism is may be associated with FH of P-CAD. FokI polymorphism may predispose to the development of P-CAD among healthy people over the next years.

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Sridevi, Ugrappa, Ajay Jain, Velpula Nagalaxmi, Ugrappa Vijay Kumar, and Stuti Goyal. "Expression of E-cadherin in normal oral mucosa, in oral precancerous lesions and in oral carcinomas." European Journal of Dentistry 09, no. 03 (2015): 364–72. http://dx.doi.org/10.4103/1305-7456.163238.

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ABSTRACT Objective: The aim of the present study was to assess the expression of E-cad in oral precancerous lesions and conditions and oral carcinomas in comparison with normal mucosa. Materials and Methods: Total of 50 samples were selected for the study and were categorized into five groups and 10 samples in each group as Group I-oral leukoplakia (OL), Group II-oral lichen planus (OLP), Group III-oral submucous fibrosis (OSMF), Group IV-oral squamous cell carcinoma (OSCC) and Group V-normal oral mucosa (NOM) as control group. All the samples were assessed for the expression of E-cad by immunohistochemical study. Results: Upon assessing the expression of E-cad in OL, OSMF, OLP and OSCC, as majority of the samples with OSCC (90%), OL (80%), OLP (70%) and OSMF (60%) showed mild to moderate expression of E-cad staining, which was suggestive of reduction in dysplastic cells on comparison to NOM cells. This difference in expression and variation of E-cad upon comparison with normal mucosa was statistically significant (P < 0.001). Conclusion: There is significant (P < 0.001) variation of expression of E-cad with the histopathological dysplasia of the oral precancerous lesions and conditions, and the tumor differentiation of the oral cancers. However, there was no correlation of the degree of loss of expression of E-cad with the degree of dysplasia or the tumor differentiation of oral cancers. We conclude with our study that, there is a variation in the expression of E-cad but its value as a prognostic marker is questionable.

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ŠMERINGAIOVÁ, Anna. "CROSS-CURRICULAR INTEGRATION OF TEACHING TECHNICAL DOCUMENTATION AND WORK IN 3D CAD SYSTEM." Journal of Technology and Information 14, no. 1 (2022): 34–48. http://dx.doi.org/10.5507/jtie.2022.008.

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Itani, Norihiko, Y. Watanabe, W. Lin, et al. "R&D of Ray Tracing Simulation Software and Fabrication Technologies Based on VCAD (Volume-CAD) Concept for GRIN Lens." Key Engineering Materials 381-382 (June 2008): 109–12. http://dx.doi.org/10.4028/www.scientific.net/kem.381-382.109.

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We have been developing an intellectual manufacturing process applying IT (V-Cam system fabrication processes) based on Volume-CAD (VCAD) system which can express internal information of materials. This paper introduces the ultra-precision grinding, ray tracing (optical path) simulation software ‘V-Opt’ and the measurement of actual optical functions in the development of optical element taking gradient refractive index (GRIN) lens with functionally graded material properties as a model. In finish ground GRIN lens using SD#8000 wheel, the P-V (Peek to Value) of 27.07 nm, surface roughness (Ra) of 1.83 nm is obtained. ‘V-Opt’ developed for GRIN lens have two main functions; one is the visualizations of ray tracing and the other is the evaluation of spot diagram and focal length.

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Serrano, Pablo E., Amiram Gafni, Chu-Shu Gu, et al. "Positron Emission Tomography–Computed Tomography (PET-CT) Versus No PET-CT in the Management of Potentially Resectable Colorectal Cancer Liver Metastases: Cost Implications of a Randomized Controlled Trial." Journal of Oncology Practice 12, no. 7 (2016): e765-e774. http://dx.doi.org/10.1200/jop.2016.011676.

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Purpose: To evaluate whether positron emission tomography (PET) combined with computed tomography (PET-CT) is cost saving, or cost neutral, compared with conventional imaging in management of patients with resectable colorectal cancer liver metastases. Methods: Cost evaluation of a randomized trial that compared the effect of PET-CT on surgical management of patients with resectable colorectal cancer liver metastases. Health care use data ≤ 1 year after random assignment was obtained from administrative databases. Cost analysis was undertaken from the perspective of a third-party payer (ie, Ministry of Health). Mean costs with 95% credible intervals (CrI) were estimated by using a Bayesian approach. Results: The estimated mean cost per patient in the 263 patients who underwent PET-CT was $45,454 CAD (range, $1,340 to $181,420) and in the 134 control patients, $40,859 CAD (range, $279 to $293,558), with a net difference of $4,327 CAD (95% CrI, −$2,207 to $10,614). The primary cost driver was hospitalization for liver surgery (difference of $2,997 CAD for PET-CT; 95% CrI, −$2,144 to $8,010), which was mainly a result of a longer length of hospital stay for the PET-CT arm (median, 7 v 6 days; P = .03) and a higher postoperative complication rate (20% v 10%; P = .01). Baseline characteristics were similar between groups, including the number of liver segments involved with cancer, number of segments resected, and type of liver resection performed. No difference in survival was detected between arms. Conclusion: PET-CT was associated with limited clinical benefit and a nonsignificant increased cost. Universal funding of PET-CT in the management of patients with resectable colorectal cancer liver metastases does not seem justified.

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Krivoshapova, Kristina, Daria Tsygankova, Evgeny Bazdyrev, and Olga Barbarash. "Frailty as an Independent Predictor of Adverse Outcomes in Patients Undergoing Direct Myocardial Revascularization." Diagnostics 14, no. 13 (2024): 1419. http://dx.doi.org/10.3390/diagnostics14131419.

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The aim of this study was to analyze the incidence and anamnestic characteristics of frail patients with stable coronary artery disease (CAD) and to evaluate the role of frailty in the development of complications and adverse outcomes in the perioperative period and early survival period after coronary artery bypass grafting (CABG). Material and methods: The study included 387 patients admitted to the clinic for a scheduled primary CABG. A seven-item questionnaire, “PRISMA-7”, was used to identify frail elderly patients before the procedure. We divided the study sample into two groups, taking into account the results of the survey: patients without frailty, n0 = 300 (77.5%), and patients with frailty, n1 = 87 (22.5%). The anamnestic and laboratory data, outcome of the surgical intervention, perioperative and early complications, and adverse outcomes were analyzed. Results: We detected frailty in 22.5% of the patients with CAD before the procedure. According to the anamnestic data and paraclinical and intraoperative findings, the groups of patients with and without frailty were comparable. The differences were revealed in the intraoperative and early postoperative periods of CABG. Thus, postoperative rhythm disturbances (19.5% vs. 10.5%, p = 0.025, V = 0.115, respectively) and transient ischemic attacks/stroke (5.7% vs. 1.3%, p = 0.031, V = 0.122, respectively) occurred significantly more often among the frail patients. There were no significant differences between the groups in the frequency of other intraoperative and early postoperative complications. In the group of frail patients, four fatal outcomes due to early postoperative ischemia were recorded, and among patients without frailty, one fatal outcome was recorded (4.5% vs. 0.3%, p = 0.010, V = 0.156, respectively). At the 1-year follow-up visit, the presence of frailty in history served as a predictor of mortality (11.5% vs. 0.6%, p ˂ 0.001, V = 0.290, respectively). Conclusion: The presence of frailty can be used as an independent predictor of an unfavorable prognosis in patients with CAD, both in the perioperative and early survival period after CABG. It should be taken into account during surgical risk assessment.

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Zhetenbayev, Nursultan, Gani Sergazin, and Dinara Seisenova. "Almaty ankle exoskeleton: comparative analysis and structural improvements of versions V.1 and V.2." Vibroengineering Procedia 58 (May 15, 2025): 147–53. https://doi.org/10.21595/vp.2025.24972.

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This paper presents a comparative analysis of the V.1 and V.2 versions of the Almaty Ankle Exoskeleton. The main objective of the study is to identify the structural and functional shortcomings observed in the first version (V.1) and to develop an improved prototype in the second version (V.2) by addressing these issues. The paper compares the kinematic schemes, CAD models, and physical prototypes of both versions, highlighting their structural differences and technical advancements. In addition, the results of a static structural analysis performed on the V.2 prototype using the Finite Element Analysis (FEA) method are presented. This analysis allowed for the evaluation of stress, strain, and displacement distribution within the structure. The results demonstrated that the exoskeleton can effectively handle applied loads, although additional reinforcement is required in certain critical regions. Overall, the findings provide a foundation for engineering solutions aimed at enhancing the functional performance of the ankle exoskeleton and its application in rehabilitation processes.

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Cường, Phan Xuân, Phạm Minh Thông, Nguyễn Khôi Việt та ін. "ÁP DỤNG BẢNG PHÂN LOẠI CAD-RADS TRONG ĐÁNH GIÁ BỆNH ĐỘNG MẠCH VÀNH MẠN TÍNH TRÊN CẮT LỚP VI TÍNH ĐA DÃY". Vietnamese Journal of Radiology and Nuclear Medicine, № 43 (10 січня 2022): 53–62. http://dx.doi.org/10.55046/vjrnm.43.48.2021.

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Mục tiêu: Áp dụng bảng phân loại CAD-RADS trong đánh giá bệnh động mạch vành mạn tính trên cắt lớp vi tính đa dãy.Đối tượng và phương pháp: Mô tả cắt ngang 179 bệnh nhân được chụp cắt lớp vi tính động mạch vành, so sánh mức độ tương hợp kết quả đọc giữa hai bác sỹ độc lập khi áp dụng phân loại CAD-RADS, và so sánh với kết quả chụp mạch vành xâm lấn.Kết quả: Có sự tương hợp mức độ rất tốt giữa 2 bác sỹ đối với CAD-RADS chung (κ=0.904), theo từng phân loại CADRADS (κ=0.827-1.00), theo động mạch vành bị hẹp (κ=0.878-0.931). Sự tương hợp rất tốt cho phân loại bổ sung G (κ=1), và S (κ=1), tương hợp mức độ trung bình cho phân loại V (κ=0.574). Giá trị ngưỡng để dự báo hẹp mạch vành có ý nghĩa là CADRADS ≥ 3. Giá trị chẩn đoán của phân loại CAD-RADS theo đoạn mạch chung: độ nhạy 77.54%, độ đặc hiệu 87.23%, giá trị dự báo dương tính 89.92%, giá trị dự báo âm tính 72.56%.Kết luận: Có mức độ tương hợp rất tốt khi áp dụng phân loại CAD-RADS trong lâm sàng; CAD-RADS có độ nhạy, độ đặc hiệu, độ chính xác cao khi so sánh với chụp mạch vành xâm lấn.

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Silvério, Sónia, Catarina Gomes, Francisco Martins, José Alexandre Reis, Paulo Durão Maurício, and José Eduardo Maté-Sánchez de Val. "Assessing the Aesthetic Performance of CAD/CAM Provisional Restorative Materials: A Spectrophotometric Analysis." Polymers 16, no. 18 (2024): 2636. http://dx.doi.org/10.3390/polym16182636.

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Achieving color match between natural teeth and restorative materials is crucial in dentistry. Factors such as the light source, brightness, and opacity influence tooth color, determined by light absorption and scattering within the material. Advances in CAD/CAM systems have enhanced prosthodontic treatments, particularly with new temporary materials, but data on their color stability and masking ability remains limited. However, data on the color stability and masking ability of these CAD/CAM materials is limited. Telio® CAD-Temp and VITA CAD-Temp® blocks were cut into slices and polished. Composite resin specimens were prepared using a custom-designed metal resin former and light-cured. Samples were paired randomly and assigned to experimental groups based on base type and thickness (n = 30). Samples were stored in a controlled environment for 24 h before color evaluation using an EasyShade® V spectrophotometer. Color difference (ΔE) was calculated using L*, a*, and b* values. Statistical analyses included the Shapiro–Wilk test, Levene’s test, and three-way ANOVA, with post-hoc comparisons using the Bonferroni method (α = 0.05). ΔE was classified according to perceptibility (PT = 1.2) and acceptability (AT = 2.7) values.

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Gutiérrez de Ravé, Eduardo, and Francisco J. Jiménez-Hornero. "A 3D Descriptive Geometry Problem-Solving Methodology Using CAD and Orthographic Projection." Symmetry 16, no. 4 (2024): 476. http://dx.doi.org/10.3390/sym16040476.

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In solving descriptive geometry (DG) problems, board (i.e., hand drawing) methods are frequently used, despite this discipline is still very important to enhance spatial vision. These methods are very different from CAD tools which are used in the field of design. CAD facilitates the realization of geometric constructions and transformations (i.e., rotation, translation, copying, scaling, alignment, and symmetry, among others) are performed analytically. For this reason, a 3D DG problem-solving methodology using CAD and orthographic projection (CADOP) is introduced. Once the principles of DG, orthographic projection, and CAD fundamentals and tools are described, CADOP is applied to obtain (i) orthogonal views; (ii) principal lines of a plane; (iii) true-size view of a plane; (iv) parallelism, perpendicularity, and distance, and (v) angles. Considering the user coordinate system in CADOP allows one to place the horizontal plane in the suitable position to solve DG problems directly in one step. In the traditional methods, the use of auxiliary views must be carried out in several steps instead. The dynamic management of the 3D view of the scene is facilitated in CADOP, improving its understanding, and achieving the precision inherent in analytical calculations.

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Weng, Ruiqiang, Sudong Liu, Xiaodong Gu, and Zhixiong Zhong. "Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes." Open Life Sciences 16, no. 1 (2021): 884–98. http://dx.doi.org/10.1515/biol-2021-0091.

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Abstract Type 2 diabetes mellitus (T2DM) is known as a risk factor for coronary in-stent restenosis (ISR) in patients with coronary artery disease (CAD). Evidence suggests that B cells play a functional role in the progression of atherosclerotic lesions. However, the B cell receptor (BCR) repertoire in patients with ISR remains unclear. This study aims to profile the BCR repertoire in patients with coronary ISR/T2DM. A total of 21 CAD patients with or without ISR/T2DM were enrolled. PBMCs were isolated and examined for BCR repertoire profiles using DNA-seq. Our results showed that the diversity of amino acid sequences in ISR DM patients was higher than that in ISR −DM patients. The frequencies of 21 V/J paired genes differed between ISR DM and −ISR DM patients, while frequencies of 5 V/J paired genes differed between ISR DM and ISR −DM. The −ISR −DM group presented the highest clonotype overlap rate, while ISR DM patients presented the lowest overlap rate. Our study presented the BCR repertoires in patients with ISR/T2DM. The data suggested different BCR signatures between patients with ISR and T2DM. Further analysis of BCR profiles would enhance understanding of ISR.

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Zhang, Wei, and Zheng Wang. "Design and Implementation of a CAD Software System for Hull Lines." Applied Mechanics and Materials 668-669 (October 2014): 1343–46. http://dx.doi.org/10.4028/www.scientific.net/amm.668-669.1343.

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A CAD software system for hull lines based on .NET is introduced in terms of system construction and principle. The system adopts a 3D V-shaped fairing computing model, which sufficiently considers the consistency of lines offsets in three different projection planes. By means of tree structure for parametric hull lines and 3-dimensional modeling technology, the system supports total-process-design of hull lines. Such a system not only can draw main parameter table, lines offsets table and lines plan grid automatically, support interactive design and synchronous adjustment for hull lines, but also can cut the hull synchronously and produce the 3-dimensional model of the hull. The implementation of this CAD software system for hull lines improves the hull design efficiency and quality.

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Attinger, Pascal. "mūt ilī-šu mâtu." Nouvelles Assyriologiques Brèves et Utilitaires N.A.B.U. 5, no. 1 (2014): 8–9. https://doi.org/10.5281/zenodo.3559592.

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Le CAD a proposé de traduire lʹexpression mūt ilī-&scaron;u mâtu, litt. " mourir de la mort de son dieu ", par " to die a natural death " (CAD M/II 319 s.v. mūtu f, 2ʹ), et cette suggestion a été en général acceptée (v. par ex. D. Charpin, Cahiers de N.A.B.U. 1 [1990] 122 n. e ; J. Black/A. George/N. Postgate, A Concise Dictionary of Akkadian [2000] 225 ; A.R. George, The Babylonian Gilgamesh Epic II [2003] 904 ; A Gadotti, " Gilgame&scaron;, Enkidu and the Netherworld " and the Sumerian Gilgame&scaron; Cycle, Ph. D. diss., The Johns Hopkins University [2005] 529 sq.2) ; A.R. George, CUSAS 18 [2013] 65).

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