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Journal articles on the topic 'Vaccine naïve'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Ebrahim, Fawzi, Salah Tabal, Yosra Lamami, et al. "Anti-SARS-CoV-2 IgG Antibodies Post-COVID-19 or Post-Vaccination in Libyan Population: Comparison of Four Vaccines." Vaccines 10, no. 12 (2022): 2002. http://dx.doi.org/10.3390/vaccines10122002.

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Measurement of strength and durability of SARS-COV-2 antibody response is important to understand the waning dynamics of immune response to both vaccines and infection. The study aimed to evaluate the level of IgG antibodies against SARS-CoV-2 and their persistence in recovered, naïve, and vaccinated individuals. We investigated anti-spike RBD IgG antibody responses in 10,000 individuals, both following infection with SARS-CoV-2 and immunization with SARS-COV-2 AstraZeneca, Sputnik V, Sinopharm, and Sinovac. The mean levels of anti-spike IgG antibodies were higher in vaccinated participants wi

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Nugraha, Rivan Adi, Teguh Iman Hermanto, and Imam Ma’ruf Nugroho. "NAÏVE BAYES ALGORITHM OPTIMIZATION USING PARTICLE SWARM OPTIMIZATION (PSO) FOR COVID-19 VACCINE SENTIMENT ANALYSIS ON TWITTER." Jurnal Sistem Informasi dan Ilmu Komputer Prima(JUSIKOM PRIMA) 6, no. 1 (2022): 23–28. http://dx.doi.org/10.34012/jurnalsisteminformasidanilmukomputer.v6i1.2776.

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The Covid-19 vaccine is a vaccine that is quite popular, because it is the most needed and most discussed vaccine. There are 5 types of vaccines that are very popular including AstraZeneca, Moderna, Pfizer, Sinopharm and Sinovac. Sentiment analysis is a branch of text classification with computational linguistics and natural language processing that refers to a broad field, and text mining has a function to analyze opinions, judgments, sentiments, attitudes, evaluations and emotions of a person regarding an individual, organization, certain topics, services and other activities. This study aim

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3

Rodero-Romero, Alexander, Susana Sainz de la Maza, José Ignacio Fernández-Velasco, et al. "Blood CD8+ Naïve T-Cells Identify MS Patients with High Probability of Optimal Cellular Response to SARS-CoV-2 Vaccine." Vaccines 11, no. 9 (2023): 1399. http://dx.doi.org/10.3390/vaccines11091399.

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This single-center study included 68 multiple sclerosis (MS) patients who received the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination from one of several approved vaccine preparations in Spain. Blood samples were collected one to three months after the second dose of the vaccine had been administered. Cellular immune responses to the vaccine were assessed using QuantiFERON analysis, and peripheral blood mononuclear cell subsets were assayed using flow cytometry. Response associated with higher percentages of total lymphocytes, naïve CD4+ T-cells (p = 0.028), CD8+ T-ce

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Goel, Rishi R., Sokratis A. Apostolidis, Mark M. Painter, et al. "Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination." Science Immunology 6, no. 58 (2021): eabi6950. http://dx.doi.org/10.1126/sciimmunol.abi6950.

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Novel mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their efficacy in clinical trials, data on mRNA vaccine-induced immune responses are mostly limited to serological analyses. Here, we interrogated antibody and antigen-specific memory B cells over time in 33 SARS-CoV-2 naïve and 11 SARS-CoV-2 recovered subjects. SARS-CoV-2 naïve individuals required both vaccine doses for optimal increases in antibodies, particularly for neutralizing titers against the B.1.351 variant. Memory B cells specific for full-length spike protein and the spike receptor binding domain (R

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Pan, Yi-Kan, Laurent Bartolo, Ruozhang Xu, and Yi-Kan Pan. "Naive phenotype antigen-specific CD4 +T cells persist in the memory repertoire after vaccination." Journal of Immunology 210, no. 1_Supplement (2023): 252.11. http://dx.doi.org/10.4049/jimmunol.210.supp.252.11.

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Abstract Immunization leads to activation and differentiation of antigen-specific T cells, resulting in the development of immunological memory. However, how the human immune repertoire changes after vaccination remains incompletely understood. Here, we used the live attenuated yellow fever virus (YFV) vaccine or the SARS-CoV-2 mRNA vaccine as models to track post-vaccine kinetics in healthy donors. We quantified and characterized 36 distinct YFV-specific T cell populations and 25 SARS-CoV-2-specific populations by direct ex vivo peptide-MHC tetramer staining. Unexpectedly, we found naïve-phen

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Gelanew, Tesfaye, Andargachew Mulu, Markos Abebe, et al. "A Single Dose of ChAdOx1 nCoV-19 Vaccine Elicits High Antibody Responses in Individuals with Prior SARS-CoV-2 Infection Comparable to That of Two-Dose-Vaccinated, SARS-CoV-2-Infection-Naïve Individuals: A Longitudinal Study in Ethiopian Health Workers." Vaccines 10, no. 6 (2022): 859. http://dx.doi.org/10.3390/vaccines10060859.

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Single-dose COVID-19 vaccines, mostly mRNA-based vaccines, are shown to induce robust antibody responses in individuals who were previously infected with SARS-CoV-2, suggesting the sufficiency of a single dose for those individuals in countries with limited vaccine supply. However, these important data are limited to developed nations. We conducted a prospective longitudinal study among Ethiopian healthcare workers who received a ChAdOx1 nCoV-19 vaccine. We compared the geometric mean titers (GMTs) of the SARS-CoV-2 receptor-binding domain (RBD)-specific IgG antibodies in 39 SARS-CoV-2 naïve p

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Jalil, Maaz, John M. Abraham, and Robert Hostoffer. "The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine." Allergy & Rhinology 12 (January 2021): 215265672110497. http://dx.doi.org/10.1177/21526567211049744.

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Introduction Different subtypes of vaccines have been developed to help protect populations from COVID-19. Currently, three vaccines have been authorized by the United States Food and Drug Administration for emergency use to combat the COVID-19 pandemic. With COVID-19 vaccination rates increasing, it is important to know whether immunodeficient patients have the capacity to mount an immune response with the available vaccines. Case Report A 78-year-old female with Common Variable Immunodeficiency and anti-IgA antibodies who is naïve to IVIgG treatment responded positively to a COVID-19 mRNA va

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Uprichard, Susan L., Amornrat O’Brien, Monika Evdokimova, et al. "Antibody Response to SARS-CoV-2 Infection and Vaccination in COVID-19-naïve and Experienced Individuals." Viruses 14, no. 2 (2022): 370. http://dx.doi.org/10.3390/v14020370.

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Understanding the magnitude of responses to vaccination during the ongoing SARS-CoV-2 pandemic is essential for ultimate mitigation of the disease. Here, we describe a cohort of 102 subjects (70 COVID-19-naïve, 32 COVID-19-experienced) who received two doses of one of the mRNA vaccines (BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna)). We document that a single exposure to antigen via infection or vaccination induces a variable antibody response which is affected by age, gender, race, and co-morbidities. In response to a second antigen dose, both COVID-19-naïve and experienced subjects exhi

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Fu, Jia, Xiaoying Shen, Mark Anderson, et al. "Correlation of Binding and Neutralizing Antibodies against SARS-CoV-2 Omicron Variant in Infection-Naïve and Convalescent BNT162b2 Recipients." Vaccines 10, no. 11 (2022): 1904. http://dx.doi.org/10.3390/vaccines10111904.

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In vaccine clinical trials, both binding antibody (bAb) levels and neutralization antibody (nAb) titers have been shown to be correlates of SARS-CoV-2 vaccine efficacy. We report a strong correlation bAb and nAb responses against the SARS-CoV-2 Omicron (BA.1) variant in infection-naïve and previously infected (convalescent) individuals after one and two doses of BNT162b2 vaccination. The vaccine-induced bAb levels against Omicron were significantly lower compared to previous variants of concern in both infection-naive and convalescent individuals, with the convalescent individuals showing sign

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He, Mingyue, Rui Song, Zakir Shaik, et al. "COVID-19 Vaccine Antibody Response in a Single-Center Urban Hemodialysis Unit." Vaccines 11, no. 7 (2023): 1252. http://dx.doi.org/10.3390/vaccines11071252.

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Background: The longitudinal response to the COVID-19 vaccines among patients on hemodialysis with and without prior SARS-CoV-2 infection has not been well characterized. Methods: To guide vaccination strategies in patients on hemodialysis, it is critical to characterize the longevity and efficacy of the vaccine; therefore, we conducted a prospective single-center monthly antibody surveillance study between March 2021 and March 2022 to investigate the dynamic humoral response to a series of COVID-19 mRNA vaccines in patients on hemodialysis with and without prior SARS-CoV-2 infection. Monthly

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Ge, Pan, and Ted M. Ross. "Evaluation of Pre-Pandemic Trivalent COBRA HA Vaccine in Mice Pre-Immune to Historical H1N1 and H3N2 Influenza Viruses." Viruses 15, no. 1 (2023): 203. http://dx.doi.org/10.3390/v15010203.

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Initial exposure to influenza virus(es) during early childhood produces protective antibodies that may be recalled following future exposure to subsequent viral infections or vaccinations. Most influenza vaccine research studies use immunologically naïve animal models to assess vaccine effectiveness. However, most people have an extensive influenza immune history, with memory cells produced by viruses or vaccines representing multiple influenza viruses. In this study, we explored the effect influenza seasonal virus-induced immunity has on pre-pandemic influenza virus vaccination. The mice that

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Shurrab, Farah M., Duaa W. Al-Sadeq, Haissam Abou-Saleh, et al. "Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative Study." Vaccines 10, no. 2 (2022): 191. http://dx.doi.org/10.3390/vaccines10020191.

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The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was shown that the magnitude of the neutralizing antibody (NAbs) response correlates with the degree of protection. However, the difference between the immune response in naïve mRNA-vaccinated and previously infected (PI) individuals is not well studied. We investigated the level of NAbs in naïve and PI individuals after 1 to 26 (median = 6) weeks of the second dose of BNT162b2 or m

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Juarez, Ignacio, Isabel Pérez-Flores, Arianne S. Aiffil Meneses, et al. "Immunosuppressive Therapy Modifies Anti-Spike IgG Subclasses Distribution After Four Doses of mRNA Vaccination in a Cohort of Kidney Transplant Recipients." Vaccines 13, no. 2 (2025): 123. https://doi.org/10.3390/vaccines13020123.

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Background: IgG4 is the least immunogenic subclass of IgG. Immunization with mRNA vaccines against SARS-CoV-2, unlike other vaccines, induces an increase in IgG4 against the spike protein in healthy populations. This study investigated whether immunosuppressive therapy affects the immune response, focusing on IgG subclass changes, to four doses of mRNA vaccine in kidney transplant recipients (KTRs). Methods: This study includes 146 KTRs and 23 dialysis patients (DPs) who received three mRNA-1273 vaccine doses and a BNT162b2 booster. We evaluated anti-spike IgG titers and subclasses, T-CD4+ and

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Ben Hamouda, Wafa, Mariem Hanachi, Sonia Ben Hamouda, et al. "A Longitudinal Study in Tunisia to Assess the Anti-RBD IgG and IgA Responses Induced by Three Different COVID-19 Vaccine Platforms." Tropical Medicine and Infectious Disease 9, no. 3 (2024): 61. http://dx.doi.org/10.3390/tropicalmed9030061.

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Background: Vaccination constitutes the best strategy against COVID-19. In Tunisia, seven vaccines standing for the three main platforms, namely RNA, viral vector, and inactivated vaccines, have been used to vaccinate the population at a large scale. This study aimed to assess, in our setting, the kinetics of vaccine-induced anti-RBD IgG and IgA antibody responses. Methods: Using in-house developed and validated ELISA assays, we measured anti-RBD IgG and IgA serum antibodies in 186 vaccinated workers at the Institut Pasteur de Tunis over 12 months. Results: We showed that RNA vaccines were the

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Prendecki, Maria, Candice Clarke, Helena Edwards, et al. "Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression." Annals of the Rheumatic Diseases 80, no. 10 (2021): 1322–29. http://dx.doi.org/10.1136/annrheumdis-2021-220626.

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ObjectiveThere is an urgent need to assess the impact of immunosuppressive therapies on the immunogenicity and efficacy of SARS-CoV-2 vaccination.MethodsSerological and T-cell ELISpot assays were used to assess the response to first-dose and second-dose SARS-CoV-2 vaccine (with either BNT162b2 mRNA or ChAdOx1 nCoV-19 vaccines) in 140 participants receiving immunosuppression for autoimmune rheumatic and glomerular diseases.ResultsFollowing first-dose vaccine, 28.6% (34/119) of infection-naïve participants seroconverted and 26.0% (13/50) had detectable T-cell responses to SARS-CoV-2. Immune resp

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Mancuso, Roberta, Simone Agostini, Lorenzo Agostino Citterio, Debora Chiarini, Maria Antonia Santangelo, and Mario Clerici. "Systemic and Mucosal Humoral Immune Response Induced by Three Doses of the BNT162b2 SARS-CoV-2 mRNA Vaccines." Vaccines 10, no. 10 (2022): 1649. http://dx.doi.org/10.3390/vaccines10101649.

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BNT162b2 (BioNTech/Pfizer) was the first SARS-CoV-2 mRNA vaccine approved by the European Medicines Agency. We monitored the long-term humoral responses of healthcare workers (HCWs) who received three vaccine doses. A total of 59 healthcare workers were studied: 47 were never SARS-CoV-2-infected (naïve-HCWs), and 12 (infected-HCWs) recovered from COVID-19 before the first vaccine. Serum and saliva were collected at baseline (before the first dose), just before the second dose, 1, 3, 6, and 9 months after the second dose, and 10 days after the third vaccine. SARS-CoV-2-specific IgG and IgA were

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M. Khairul Anam, Rahmaddeni, Muhammad Bambang Firdaus, Hadi Asnal, and Hamdani. "Sentiment Analysis to analyze Vaccine Enthusiasm in Indonesia on Twitter Social Media." JAIA - Journal of Artificial Intelligence and Applications 1, no. 2 (2021): 23–27. http://dx.doi.org/10.33372/jaia.v1i2.794.

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Vaccines are one way to prevent the coronavirus from entering the human body, although it is not 100% accurate. However, the implementation of vaccination in Indonesia is still controversial. People give their opinions directly or through social media such as Twitter. Retrieval of tweets using the Twitter API and using python. The data obtained is then preprocessed using case folding, cleaning, tokenizing, filtering, and stemming. After that, the model was evaluated using the Naive Bayes method. Naïve Bayes is a classification method that can predict the probability of a class to produce decis

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Nufia Alfi Rohyana, Aris Wahyu Murdiyanto, and Kharisma. "Analisis Sentimen Di Media Sosial Twitter Dengan Studi Kasus Vaksinasi Covid-19." INDONESIAN JOURNAL ON DATA SCIENCE 1, no. 1 (2023): 20–31. http://dx.doi.org/10.30989/ijds.v1i1.861.

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    With the COVID-19 pandemic, the World Health Organization or WHO conducted research and research trials on the COVID-19 vaccine. The Indonesian government has made several policies, one of which is the "Mass Vaccination Program". However, the COVID-19 vaccination program in the field received mixed responses in the community, there were those who supported the vaccine program and some who rejected the vaccine program. In this study, researchers conducted research on sentiment analysis on the opinion of vaccination programs against anti-vaccine community groups based

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Gobbi, Federico, Dora Buonfrate, Lucia Moro, et al. "Antibody Response to the BNT162b2 mRNA COVID-19 Vaccine in Subjects with Prior SARS-CoV-2 Infection." Viruses 13, no. 3 (2021): 422. http://dx.doi.org/10.3390/v13030422.

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Although antibody levels progressively decrease following SARS-CoV-2 infection, the immune memory persists for months. Thus, individuals who naturally contracted SARS-CoV-2 are expected to develop a more rapid and sustained response to COVID-19 vaccines than naïve individuals. In this study, we analyzed the dynamics of the antibody response to the BNT162b2 mRNA COVID-19 vaccine in six healthcare workers who contracted SARS-CoV-2 in March 2020, in comparison to nine control subjects without a previous infection. The vaccine was well tolerated by both groups, with no significant difference in th

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Tu, Hsin-Fang, Julia Tao, Ming-Hung Hu, et al. "Type I Interferon Modulates the Function of Ly6C High-Expressing Naïve CD8+ T Cells to Promote an Antitumor Response." Vaccines 13, no. 3 (2025): 246. https://doi.org/10.3390/vaccines13030246.

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Background: Ly6C expression in naïve CD8+ T cells plays a crucial role in enhancing their effector activity, suggesting potential implications for cancer immunotherapy. This study investigates the functional impact of Ly6C expression on CD8+ T cells and explores albumin-conjugated IFNβ (Alb-IFNβ) as a strategy to modulate Ly6C expression and improve cancer vaccine efficacy. Methods: We analyzed the functional differences between Ly6C high-expressing (Ly6Chi) and Ly6C low-expressing (Ly6Clo) naïve CD8+ T cells in tumor suppression. To assess the role of type I interferon signaling, we administe

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Skarlupka, Amanda L., Xiaojian Zhang, Uriel Blas-Machado, Spencer F. Sumner, and Ted M. Ross. "Multi-Influenza HA Subtype Protection of Ferrets Vaccinated with an N1 COBRA-Based Neuraminidase." Viruses 15, no. 1 (2023): 184. http://dx.doi.org/10.3390/v15010184.

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The influenza neuraminidase (NA) is a promising target for next-generation vaccines. Protection induced by vaccination with the computationally optimized broadly reactive NA antigen (N1-I COBRA NA) was characterized in both influenza serologically naive and pre-immune ferret models following H1N1 (A/California/07/2009, CA/09) or H5N1 (A/Vietnam/1203/2004, Viet/04) influenza challenges. The N1-I COBRA NA vaccine elicited antibodies with neutralizing ELLA activity against both seasonal and pandemic H1N1 influenza, as well as the H5N1 influenza virus. In both models, N1-I COBRA NA-vaccinated ferr

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Kuwata, Keisuke, Naotoshi Kuninaga, Yoko Kimura, et al. "Evaluation of Immune Status of Pigs against Classical Swine Fever for Three Years after the Initiation of Vaccination in Gifu Prefecture, Japan." Pathogens 13, no. 8 (2024): 616. http://dx.doi.org/10.3390/pathogens13080616.

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In 2018, classical swine fever (CSF) reemerged in Gifu Prefecture, Japan, after 26 years of absence, and vaccination of domestic pigs using a live attenuated vaccine was initiated in 2019. Because the vaccine efficacy in piglets is influenced by the maternal antibody levels, vaccination should be administered at the optimal age by assuming the antibody level in sows. In this study, the shift in the antibody titer distribution in sows due to the initiation of vaccination to naïve herds and its influence on the vaccine-induced immunity rate in fattening pigs were investigated for 3 years. The re

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Hampson, Alan W. "Vaccines for Pandemic Influenza. The History of our Current Vaccines, their Limitations and the Requirements to Deal with a Pandemic Threat." Annals of the Academy of Medicine, Singapore 37, no. 6 (2008): 510–17. http://dx.doi.org/10.47102/annals-acadmedsg.v37n6p510.

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Fears of a potential pandemic due to A(H5N1) viruses have focussed new attention on our current vaccines, their shortcomings, and concerns regarding global vaccine supply in a pandemic. The bulk of current vaccines are inactivated split virus vaccines produced from egggrown virus and have only modest improvements compared with those first introduced over 60 years ago. Splitting, which was introduced some years ago to reduce reactogenicity, also reduces the immunogenicity of vaccines in immunologically naïve recipients. The A(H5N1) viruses have been found poorly immunogenic and present other ch

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Noor, Laiba, Syeda Momna Ishtiaq, Farhat Batool, and Muhammad Imran Arshad. "Age-dependent trends in adverse reactions of SARS-CoV-2 vaccines: A narrative review." AIMS Allergy and Immunology 8, no. 3 (2024): 146–66. http://dx.doi.org/10.3934/allergy.2024008.

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<p>Since the initiation of immunization against SARS-CoV-2, the adverse reactions of vaccines have remained a major contributor to vaccine hesitancy. Their occurrence has been attributed to the immune response against the administered antigen, which is affected by different factors including the age of the vaccine recipient. The trends of the adverse reactions of COVID-19 vaccines have shown a higher frequency in younger adults (18–64 years old) than in the older population (≥65 years). One of the potential reasons is the healthy and efficient immune systems of younger individuals, which

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Sekiya, Toshiki, Marumi Ohno, Naoki Nomura, et al. "Selecting and Using the Appropriate Influenza Vaccine for Each Individual." Viruses 13, no. 6 (2021): 971. http://dx.doi.org/10.3390/v13060971.

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Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global threat to humans, causing high morbidity and mortality each year. The effectiveness of the vaccine is largely dependent on how well matched the vaccine strains are with the circulating influenza virus strains. Furthermore, low vaccine efficacy in naïve populations such as young children, or in the elderly, who possess weakened immune systems, indicates that influenza vaccines need to be more personalized to provide broader community protection. Advances in both vaccine

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Karachi, Aida, Farhad Dastmalchi, Ashley O’Malley, Megan Saia, Duane Mitchell, and Maryam Rahman. "IMMU-07. CELLULAR IMMUNOTHERAPY TO OVERCOME TEMOZOLOMIDE INDUCED T CELL EXHAUSTION IN GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (2019): vi120. http://dx.doi.org/10.1093/neuonc/noz175.501.

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Abstract INTRODUCTION We have previously demonstrated that standard dose (SD) temozolomide results in T cell exhaustion in glioblastoma. In this study, we hypothesized that cellular immunotherapies will prevent T cell exhaustion. We tested temozolomide treatment with adoptive T cell transfer alone, dendritic cell (DC) vaccines alone and T cell transfer in combination with DC vaccines. METHOD GL-261-gp100 tumor-bearing mice were treated with SD (50 mg/kg for 5 days) or metronomic dose (MD) (25 mg/kg for 10 days) temozolomide. CD3+ T cells were isolated from Pmel mice and infused intravenously.

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Hatabah, Dunia, Sneh Lata Gupta, Grace Mantus, et al. "Longitudinal Surveillance of COVID-19 Antibodies in Pediatric Healthcare Workers." Vaccines 13, no. 2 (2025): 163. https://doi.org/10.3390/vaccines13020163.

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Background: Vaccines against COVID-19 target the spike protein. There is minimal information on longitudinal COVID-19 immune profiling in recovered versus naïve and vaccinated versus non-vaccinated healthcare workers (HCWs). Methods: This is a prospective longitudinal observational cohort of pediatric HCWs (pHCWs) conducted during 2020–2022 at an academic center, exploring the impact of COVID-19 vaccination on immunoglobulin G (IgG) antibody titers over time and cross-reactivity with other coronaviruses, including SARS-CoV-1, MERS-CoV, and seasonal coronaviruses (HCoV-HKU1 and HCoV-OC43). Resu

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Hwang, Ji-Young, Yunhwa Kim, Kyung-Min Lee, et al. "Humoral and Cellular Responses to COVID-19 Vaccines in SARS-CoV-2 Infection-Naïve and -Recovered Korean Individuals." Vaccines 10, no. 2 (2022): 332. http://dx.doi.org/10.3390/vaccines10020332.

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In the face of a global COVID-19 vaccine shortage, an efficient vaccination strategy is required. Therefore, the immunogenicity of single or double COVID-19 vaccination doses (ChAdOX1, BNT162b2, or mRNA-1273) of SARS-CoV-2-recovered individuals was compared to that of unvaccinated individuals with SARS-CoV-2 infection at least one year post-convalescence. Moreover, the immunogenicity of SARS-CoV-2-naïve individuals vaccinated with a complete schedule of Ad26.CoV2.S, ChAdOX1, BNT162b2, mRNA-1273, or ChAdOX1/BNT162b2 vaccines was evaluated. Anti-SARS-CoV-2 S1 IgG antibody (S1-IgG), pseudotyped v

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Coccia, Margherita, Wivine Burny, Marie-Ange Demoitié, Paul Gillard, Robert A. van den Berg, and Robbert van der Most. "Subsequent AS01-adjuvanted vaccinations induce similar transcriptional responses in populations with different disease statuses." PLOS ONE 17, no. 11 (2022): e0276505. http://dx.doi.org/10.1371/journal.pone.0276505.

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Transcriptional responses to adjuvanted vaccines can vary substantially among populations. Interindividual diversity in levels of pathogen exposure, and thus of cell-mediated immunological memory at baseline, may be an important determinant of population differences in vaccine responses. Adjuvant System AS01 is used in licensed or candidate vaccines for several diseases and populations, yet the impact of pre-existing immunity on its adjuvanticity remains to be elucidated. In this exploratory post-hoc analysis of clinical trial samples (clinicalTrials.gov: NCT01424501), we compared gene express

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Ramadhan, Nur Ghaniaviyanto, and Faisal Dharma Adhinata. "Sentiment analysis on vaccine COVID-19 using word count and Gaussian Naïve Bayes." Indonesian Journal of Electrical Engineering and Computer Science 26, no. 3 (2022): 1765. http://dx.doi.org/10.11591/ijeecs.v26.i3.pp1765-1772.

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Since the <span>Coronavirus disease 2019 (COVID-19) pandemic hit the world, it had a significant negative impact on individuals, governments, and the global economy. One way to reduce the negative impact of COVID-19 is to vaccinate. Briefly, vaccination aims to enable the formed immune system to remember the characteristics of the targeted viral pathogen and be able to initiate an immune response that is rapid and strong enough to defeat future live viral pathogens. However, there are still many people in the world who are anti-vaccine. This certainly greatly hampers the process of accel

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Indriyani, Eva Rahma, Paradise Paradise, and Merlinda Wibowo. "Perbandingan Metode Naïve Bayes dan Support Vector Machine Untuk Analisis Sentimen Terhadap Vaksin Astrazeneca di Twitter." JURNAL MEDIA INFORMATIKA BUDIDARMA 6, no. 3 (2022): 1545. http://dx.doi.org/10.30865/mib.v6i3.4220.

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The implementation of Covid-19 vaccination in Indonesia turned out to have various pro and contra opinions from the public. The discovery of disinformation and misinformation about vaccines spread through social media content affects a person's absorption of information so which leads to vaccine delays. When in fact, vaccination is one of the biggest and most effective contributions to preventing the Covid-19 pandemic. Astrazeneca is one of the vaccines provided by the Indonesian government. This vaccine used to be controversial amongst the public regarding its halalness and the safety of the

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Bai, Jian-ying, Yong-tao Yang, Rong Zhu, et al. "CpG oligodeoxynucleotides discriminately enhance binding capacity of human naïve B cells to Hepatitis B virus epitopes." Canadian Journal of Microbiology 58, no. 6 (2012): 752–59. http://dx.doi.org/10.1139/w2012-045.

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CpG oligodeoxynucleotides (CpG ODN) have the potential to enhance the antigen-presenting cells function of human naïve B cells. In this study, we aim to define the effect of CpG ODNs on the binding capacity of human naïve B cells for different Hepatitis B virus (HBV) epitopes. Three HLA-A2 restricted epitopes were selected to incubate with CpG ODN-primed human naïve B cells. Binding capacity for each epitope and expression of CD80, CD86, class I major histocompatibility complex (MHC), and class II MHC of naïve B cells was tested, respectively, by flow cytometry. CpG ODNs, especially ODN 2216,

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Babaer, Duaa, Suneetha Amara, Brenda S. McAdory, et al. "Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells." Cancers 11, no. 5 (2019): 672. http://dx.doi.org/10.3390/cancers11050672.

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Mammaglobin-A (MamA) is overexpressed in 40–80% of all human breast cancers. Recent phase I clinical trials of the MamA DNA vaccine showed encouraging safety outcomes. However, this vaccine elicited only a modest increase in MamA specific CD8+T lymphocyte (CTL) activation. As vaccine adjuvants play a critical role in enhancing the immunotherapeutic efficiency of vaccines, we tested the potential role of three synthetic CpG oligodeoxynucleotides (ODN2216—class A ODN, ODN2006—class B ODN, and ODN M362—class C ODN) to further enhance MamA specific CTL responses. Towards this, naïve CD8+T cells we

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Wolff, Janika, Martin Beer, and Bernd Hoffmann. "Cross-Protection of an Inactivated and a Live-Attenuated Lumpy Skin Disease Virus Vaccine against Sheeppox Virus Infections in Sheep." Vaccines 11, no. 4 (2023): 763. http://dx.doi.org/10.3390/vaccines11040763.

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Sheeppox virus (SPPV) (genus Capripoxvirus, family Poxviridae) infections are a highly virulent and contagious disease of sheep with a high morbidity and mortality, especially in naïve populations and young animals. For the control of SPPV, homologous and heterologous live-attenuated vaccines are commercially available. In our study, we compared a commercially available live-attenuated lumpy skin disease virus (LSDV) vaccine strain (Lumpyvax) with our recently developed inactivated LSDV vaccine candidate regarding their protective efficacy against SPPV in sheep. Both vaccines were proven to be

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Ramadhani, Slamet Harry, and Muhammad Iwan Wahyudin. "Analisis Sentimen Terhadap Vaksinasi Astra Zeneca pada Twitter Menggunakan Metode Naïve Bayes dan K-NN." Jurnal JTIK (Jurnal Teknologi Informasi dan Komunikasi) 6, no. 4 (2022): 526–34. http://dx.doi.org/10.35870/jtik.v6i4.530.

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The number of positive examples of Coronavirus continues to grow every day, especially in Indonesia. In an effort to reduce the surge in the higher case, the government carried out vaccination programs provided free for all Indonesian people. One vaccine given to Masyara-kat is the Astra Zeneca vaccine. In the provision of these vaccines bring benefits and losses in the community, some are supported and doubtful, some even refuse. On social media Twitter, Astra Zeneca is one of the most widely discussed in social media because of the many opinions or opinions that have sprung up from various c

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Galvez, Nicolas M. S., Jorge A. Soto, Susan M. Bueno, and Alexis M. Kalergis. "The humoral immune response elicited upon immunization with recombinant BCG vaccines protects against hRSV and hMPV in a murine preclinical model." Journal of Immunology 204, no. 1_Supplement (2020): 245.23. http://dx.doi.org/10.4049/jimmunol.204.supp.245.23.

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Abstract Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are among the main etiological agents responsible of acute lower respiratory tract infections in vulnerable populations worldwide. Despite their clinical relevance, the licensing of a safe and effective vaccine has not been achieved. Considering this, our laboratory developed two different recombinant Mycobacterium bovis BCG strains as vaccine candidates. These recombinant BCGs express either the hRSV-Nucleoprotein (rBCG-N) or the hMPV-Phosphoprotein (rBCG-P). Both vaccines prototypes were able to promote cellul

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Vega-Magaña, Natali, José Francisco Muñoz-Valle, Marcela Peña-Rodríguez, et al. "Specific T-Cell Immune Response to SARS-CoV-2 Spike Protein over Time in Naïve and SARS-CoV-2 Previously Infected Subjects Vaccinated with BTN162b2." Vaccines 10, no. 7 (2022): 1117. http://dx.doi.org/10.3390/vaccines10071117.

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Due to the COVID-19 pandemic, the rapid development of vaccines against SARS-CoV-2 has been promoted. BNT162b2 is a lipid-nanoparticle mRNA vaccine with 95% efficacy and is the most administered vaccine globally. Nevertheless, little is known about the cellular immune response triggered by vaccination and the immune behavior over time. Therefore, we evaluated the T-cell immune response against the SARS-CoV-2 spike protein and neutralization antibodies (nAbs) in naïve and SARS-CoV-2 previously infected subjects vaccinated with BTN162b2. Methods: Forty-six BTN162b2 vaccinated subjects were inclu

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Masyeni, Sri, Edison Johar, Anak Agung Gede Budhitresna, et al. "Immunogenicity and Reactogenicity of CoronaVac: A Cohort Study." COVID 2, no. 4 (2022): 485–91. http://dx.doi.org/10.3390/covid2040035.

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The ongoing COVID-19 pandemic remained a major public health concern despite a large-scale deployment of vaccines. One of the vaccines is CoronaVac, an inactivated vaccine. The efficacy of the vaccine was estimated at 50.7–83.5% in clinical trials. However, the real-world efficacy often differed. This study described CoronaVac post-vaccination reactogenicity and immunogenicity. Serum was collected on days 0, 28, 56 and 84 from participants who received CoronaVac in March–May 2021. Anti-SARS-CoV-2 Spike receptor binding domain was measured using an Elecsys® quantitative assay. Participants were

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Perez-Contreras, Ana, Catalina Barboza-Solis, Shahnas M. Najimudeen, et al. "Pathogenic and Transmission Potential of Wildtype and Chicken Embryo Origin (CEO) Vaccine Revertant Infectious Laryngotracheitis Virus." Viruses 13, no. 4 (2021): 541. http://dx.doi.org/10.3390/v13040541.

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Infectious laryngotracheitis (ILT) is an infectious upper respiratory tract disease that impacts the poultry industry worldwide. ILT is caused by an alphaherpesvirus commonly referred to as infectious laryngotracheitis virus (ILTV). Vaccination with live attenuated vaccines is practiced regularly for the control of ILT. However, extensive and improper use of live attenuated vaccines is related to vaccine viruses reverting to virulence. An increase in mortality and pathogenicity has been attributed to these vaccine revertant viruses. Recent studies characterized Canadian ILTV strains originatin

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Imelda, Imelda, and Arief Ramdhan Kurnianto. "Naïve Bayes and TF-IDF for Sentiment Analysis of the Covid-19 Booster Vaccine." Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) 7, no. 1 (2023): 1–6. http://dx.doi.org/10.29207/resti.v7i1.4467.

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The booster vaccine polemic became a trending topic on Twitter and reaped many pros and cons. This booster vaccine began to be distributed on January 12, 2022. This booster vaccine program was implemented free of charge for the people of Indonesia to prevent the new variant of Covid-19, Omicron. The contribution of this study is to analyze the sentiment of booster vaccines to prevent covid-19 using the Naïve Bayes and TF-IDF methods. We conducted sentiment analysis to determine whether the tweet was positive, negative, or neutral. The solution used is the Naïve Bayes method and TF-IDF. The rol

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Moncunill, Gemma, Anja Scholzen, Maximillian Mpina, et al. "Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization." Science Translational Medicine 12, no. 543 (2020): eaay8924. http://dx.doi.org/10.1126/scitranslmed.aay8924.

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Identifying immune correlates of protection and mechanisms of immunity accelerates and streamlines the development of vaccines. RTS,S/AS01E, the most clinically advanced malaria vaccine, has moderate efficacy in African children. In contrast, immunization with sporozoites under antimalarial chemoprophylaxis (CPS immunization) can provide 100% sterile protection in naïve adults. We used systems biology approaches to identifying correlates of vaccine-induced immunity based on transcriptomes of peripheral blood mononuclear cells from individuals immunized with RTS,S/AS01E or chemoattenuated sporo

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Ferrari, Ludovica, Mirko Compagno, Laura Campogiani, et al. "Increased Mild Vaccine-Related Side Effects and Higher Specific Antibody Titers in Health Care Workers with Previous SARS-CoV-2 Infection after the mRNA BNT162b2 Vaccine." Vaccines 10, no. 8 (2022): 1238. http://dx.doi.org/10.3390/vaccines10081238.

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Background: to evaluate whether prior SARS-CoV-2 infection affects side effects and specific antibody production after vaccination with BNT162b2. Methods: We included 1106 health care workers vaccinated with BNT162b2. We assessed whether prior SARS-CoV-2 infection affects the number and type of side effects and performed a nested case–control analysis comparing plasma levels of specific IgG titers between SARS-CoV-2-naïve and previously infected subjects after the first and the second vaccine doses. Results: After the first dose, SARS-CoV-2-naïve subjects experienced side effects more often th

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Singh, Nishith K., Joseph W. Kim, Christopher Ryan Heery, et al. "A randomized phase II clinical trial of enzalutamide in combination with the therapeutic cancer vaccine, PSA tricom, in metastatic, castration resistant prostate cancer." Journal of Clinical Oncology 31, no. 15_suppl (2013): TPS5104. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.tps5104.

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TPS5104 Background: There is a strong rationale to combine therapeutic cancer vaccines with hormonal abrogation in prostate cancer. Androgen abrogation augments T-cell trafficking to prostate, decreases immune tolerance, increases production of naïve thymic T-cells, enhances cytotoxic T-cell repertoire. PSA TRICOM (PROSTVAC) is a therapeutic, viral-vector based, off-the-shelf, cancer vaccine of PSA & 3 co-stimulatory molecules in phase III testing. This was developed at the NCI in collaboration with Bavarian Nordic Immunotherapeutics. It has demonstrated safety and survival benefit in a ra

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Manurip, Kevin, and Debi Irawan. "Analisis Sentimen Distribusi Vaksin COVID-19 di Indonesia Menggunakan Algoritma Naïve Bayes Classifier." Jurnal Ilmiah Universitas Batanghari Jambi 22, no. 2 (2022): 1205. http://dx.doi.org/10.33087/jiubj.v22i2.2397.

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Since the Indonesian government officially announced the first case of COVID-19, traditional media and social media content related to COVID-19 has increased dramatically. On the one hand, the media talks about prevention, symptom recognition and about prevention, symptom recognition and treatment are massive. Sentiment Analysis or commonly called opinion mining, is a field of study that analyzes opinions, sentiments, evaluations, judgments, attitudes, and emotions towards entities and is implemented on social media content. This becomes interesting and important for certain parties who want t

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Bement, Zachary James, Stephanie K. Norwood, and Lisa M. Shollenberger. "Understanding the early steps of the adaptive immune response to differentially-effective vaccines during chronic schistosomiasis." Journal of Immunology 204, no. 1_Supplement (2020): 167.14. http://dx.doi.org/10.4049/jimmunol.204.supp.167.14.

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Abstract Schistosomiasis is the second most burdensome parasitic disease in the world after malaria and is classified as a neglected tropical disease. Schistosomiasis is caused by an immunomodulatory helminth that can induce a Th2 biased response, which can cause Tc1 vaccine failure. Interestingly, the use of pathogenic Listeria monocytogenes vaccine vectors can overcome this failure through an unknown mechanism. Despite the promise of Listeria-vectored vaccines, there is reluctance among the vaccine community and the public to incorporate this vector into immunization programs, due to safety

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Bagno, Flávia F., Luis A. F. Andrade, Sarah A. R. Sérgio, et al. "Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine." Viruses 14, no. 3 (2022): 510. http://dx.doi.org/10.3390/v14030510.

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Previous studies have indicated that antibody responses can be robustly induced after the vaccination in individuals previously infected by SARS-CoV-2. To evaluate anti-SARS-CoV-2 humoral responses in vaccinated individuals with or without a previous history of COVID-19, we compared levels of anti-SARS-CoV-2 antibodies in the sera from 21 vaccinees, including COVID-19-recovered or -naïve individuals in different times, before and after immunization with an inactivated COVID-19 vaccine. Anti-SARS-CoV-2-specific antibodies elicited after COVID-19 and/or immunization with an inactivated vaccine w

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Livingstone, Morag, Sean Ranjan Wattegedera, Javier Palarea-Albaladejo, et al. "Efficacy of Two Chlamydia abortus Subcellular Vaccines in a Pregnant Ewe Challenge Model for Ovine Enzootic Abortion." Vaccines 9, no. 8 (2021): 898. http://dx.doi.org/10.3390/vaccines9080898.

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Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of commercial inactivated or live whole organism-based vaccines, although both have limitations particularly in terms of efficacy, safety and disease-associated outbreaks. Here we report a comparison of two experimental vaccines (chlamydial outer membrane complex (COMC) and octyl glucoside (OG)-COMC) based on detergent extracted outer membrane prepara

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Fernández-Ciriza, Leire, Álvaro González, José Luis del Pozo, et al. "COVID-19 Vaccine Booster Dose Fails to Enhance Antibody Response to Omicron Variant in Reinfected Healthcare Workers." Viruses 17, no. 1 (2025): 78. https://doi.org/10.3390/v17010078.

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The emergence of new variants and diverse vaccination regimens have raised uncertainty about vaccine effectiveness against SARS-CoV-2. This study aims to investigate the impact of Omicron primo-/reinfection and primary vaccination schedules on the immunogenicity of an mRNA-based booster dose over a six-month period. We conducted a prospective cohort study to assess the durability and level of antibodies of 678 healthcare workers fully vaccinated against COVID-19. They were categorized based on their primary vaccination regimen. Blood samples were collected before the booster dose and 1 and 6 m

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Ramadhan, Nur Ghaniaviyanto, and Faisal Dharma Adhinata. "Sentiment analysis on vaccine COVID-19 using word count and Gaussian Naïve Bayes." Indonesian Journal of Electrical Engineering and Computer Science 26, no. 3 (2022): 1765–72. https://doi.org/10.11591/ijeecs.v26.i3.pp1765-1772.

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Since the Coronavirus disease 2019 (COVID-19) pandemic hit the world, it had a significant negative impact on individuals, governments, and the global economy. One way to reduce the negative impact of COVID-19 is to vaccinate. Briefly, vaccination aims to enable the formed immune system to remember the characteristics of the targeted viral pathogen and be able to initiate an immune response that is rapid and strong enough to defeat future live viral pathogens. However, there are still many people in the world who are anti-vaccine. This certainly greatly hampers the process of accelerating the

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Dangi, Tanushree, Nicole M. Palacio, Sarah Sanchez, and Pablo Penaloza-MacMaster. "Characterization of cross-reactive immunity following coronavirus vaccination or natural infection." Journal of Immunology 206, no. 1_Supplement (2021): 103.13. http://dx.doi.org/10.4049/jimmunol.206.supp.103.13.

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Abstract SARS-CoV-2 has infected more than 100 million people worldwide. Several vaccine candidates have been deployed under emergency use authorization, but it is unclear whether a coronavirus (CoV) vaccine can protect against other CoV. To investigate this proof-of-concept, we evaluated cross-reactive immunity following vaccination with a modified vaccinia Ankara expressing SARS-CoV-1 spike protein. We first vaccinated C57BL/6 mice intramuscularly and then measured heterologous antibodies (SARS-CoV-2, OC43 and mouse hepatitis virus, MHV) by ELISA. Interestingly, the SARS-CoV-1 vaccine elicit

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