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Journal articles on the topic 'Vaginal gel'

Author: Grafiati

Published: 18 May 2024

Last updated: 25 July 2025

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1

Mehta, Anirudh, Saurabh Dani, and Alaka Godbole. "A multicentre, randomized, double blind, placebo controlled pilot study to evaluate the efficacy and safety of colloidal Nano silver gel (SilverSol) in the treatment of bacterial vaginosis, vulvovaginal candidiasis and trichomoniasis." Indian Journal of Obstetrics and Gynecology Research 11, no. 1 (2024): 83–89. http://dx.doi.org/10.18231/j.ijogr.2024.015.

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The study evaluated the efficacy and safety of colloidal nano silver gel (SilverSol Vagigel) (A patented technology from American Biotech Labs, USA) in combination with 0.2% lactic acid in the female subjects for the treatment of vaginal infections.This study was a multicenter, randomized, double-blind, placebo-controlled pilot study in which post-menarchal female subjects between 18 and 65 years of age clinically diagnosed with bacterial vaginosis and vulvovaginal candidiasis were enrolled. The participants were randomized to receive treatment with SilverSol Vagigel or placebo (vehicle) gel (

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2

Strandberg, Kristi L., Marnie L. Peterson, Ying-Chi Lin, Melinda C. Pack, David J. Chase, and Patrick M. Schlievert. "Glycerol Monolaurate Inhibits Candida and Gardnerella vaginalis In Vitro and In Vivo but Not Lactobacillus." Antimicrobial Agents and Chemotherapy 54, no. 2 (2009): 597–601. http://dx.doi.org/10.1128/aac.01151-09.

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ABSTRACT We investigated the effects of glycerol monolaurate (GML) on Lactobacillus, Candida, and Gardnerella vaginalis human vaginal microflora. Our previous work demonstrated that 6 months of GML treatment vaginally does not alter lactobacillus counts in monkeys. Candida and G. vaginalis are commonly associated with vaginal infections in women, many becoming chronic or recurrent. In vitro growth inhibition studies determined the effects of GML (0 to 500 μg/ml) against multiple Candida species and G. vaginalis. A randomized, double-blind study investigated the effects of GML on vaginal microf

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Bulavenko, O. V., V. O. Rud, and S. A. Bosui. "Vaginal gel Lactagel in correction of vaginal biocenosis in patients after gynecological operations." HEALTH OF WOMAN, no. 7(123) (September 30, 2017): 116–18. http://dx.doi.org/10.15574/hw.2017.123.116.

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The objective: to evaluate the clinical efficacy of using Lactagel for the correction of vaginal biocenosis in patients after gynecological operations. Patients and methods: 50 women of reproductive age with a violation of biocenosis of the vagina, which occurred after gynecological operations, participated in the study. We evaluated the clinical efficacy of the treatment after its conducting using the microbiological and clinical criteria of effectiveness: 1) the dynamics of the subjective signs of bacterial vaginosis on the visual-analog scale in the first day after the operation and before

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Provotorova, T. V. "Analysis of long-term results of Metrogil vaginal gel and Metrogil plus in the treatment of recurrent vaginal biocenosis disorders." Obstetrics, Gynecology and Reproduction 12, no. 2 (2018): 32–38. http://dx.doi.org/10.17749/2313-7347.2018.12.2.032-038.

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Aim: to study the efficacy of Metrogil vaginal gel and Metrogil plus in patients with recurrent vaginal biocenosis disorders. Materials and methods. A total of 234 patients were examined. Among them, 115 women with mixed flora without Candida spp in their vaginal microbiome, received Metrogil vaginal gel treatment (group 1), and 119 women with mixed flora and Candida spp. in their vaginal microbiome, received treatment with Metrogil plus applied as an intravaginal gel (group 2). To assess the treatment efficacy, patients’ complaints, objective examination data, pH-metry, smear microscopy, and

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Marques, Carlos Alberto Sá, Paloma de Barros Henrique, Haliny da Silva Magalhães, Tahira Souza Melo, and Jan Carlo Delorenzi. "In vitro antimicrobial activity of Schinus terebinthifolia Raddi metronidazole, clindamycin against Lactobacillus gasseri lauer and kandler and its implications in recurrent bacterial vaginosis." Brazilian Journal of Health Review 8, no. 1 (2025): e77790. https://doi.org/10.34119/bjhrv8n1-441.

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Bacterial vaginosis (BV) is a highly prevalent condition and the leading cause of vaginal discharge globally. It is characterized by dysbiosis, wherein hydrogen peroxide- and lactic acid-producing lactobacilli are replaced by anaerobic bacteria at elevated concentrations, including Gardnerella vaginalis, Prevotella spp., Mobiluncus spp., Atopobium spp., and others. BV can be self-diagnosed based on classical symptoms or clinically and laboratory-confirmed using Amsel criteria or Nugent scoring. Recommended treatments include oral metronidazole, secnidazole, and tinidazole, as well as vaginal f

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Uvarova, E. V., and Z. K. Batyrova. "Advantage of complex correction of vaginal microbiocenosis at an early reproductive age." Medical Council, no. 13 (October 10, 2019): 142–47. http://dx.doi.org/10.21518/2079-701x-2019-13-142-147.

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Aim of the study: evaluation of the effectiveness of the integrated use of the Vagilac line of intimate hygiene products in young women with bacterial vaginosis (BV). Design of the study: prospective randomized intervention open study. Materials and methods: 45 menstruating young women diagnosed with «BW» at the age of 11-17 years, divided into 3 equal groups, were examined. In the 1st group adolescents received oral probiotic with Lactobacillus rhamnosus GR-1® and Lactobacillus reuteri RC-14® within 15 days, in the 2nd group within 30 days. Group 3 girls, along with probiotic, used liquid soa

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Kenney, Jessica, Aixa Rodríguez, Larisa Kizima, et al. "A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 InfectionIn Vivo." Antimicrobial Agents and Chemotherapy 57, no. 8 (2013): 4001–9. http://dx.doi.org/10.1128/aac.00796-13.

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ABSTRACTWe previously showed that a prototype gel comprising zinc acetate (ZA) in carrageenan (CG) protected mice against vaginal and rectal herpes simplex virus 2 (HSV-2) challenge as well as macaques against vaginal simian-human immunodeficiency virus reverse transcriptase (SHIV-RT) challenge. In this work, we modified buffers and cosolvents to obtain a stable, nearly iso-osmolal formulation and evaluated its safety and efficacy against SHIV-RT and HSV-2.In vitrotoxicity to lactobacilli andCandida albicanswas determined. Macaques were given daily doses of ZA and CG (ZA/CG) or CG alone vagina

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Oliveira, Laura Maria Andrade, Cláudio Galuppo Diniz, Aline Augusta Sampaio Fernandes, et al. "Assessment of vaginal microbiota in Brazilian women with and without bacterial vaginosis and comparison with Nugent score." Journal of Infection in Developing Countries 12, no. 02 (2018): 127–36. http://dx.doi.org/10.3855/jidc.9532.

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Introduction: Bacterial vaginosis (BV) is characterized by the depletion of Lactobacillus spp. population and increase of other species, especially Gardnerella vaginalis and Atopobium vaginae. This study aimed to investigate the vaginal microbiota structure of Brazilian women with and without BV according to Nugent Score and to assess the correlation among Nugent score and the quantification of BV-associated bacteria. Methodology: Polymerase Chain Reaction-Denaturing Gradient Gel Electrophoresis (PCR-DGGE) assay was employed to characterize the vaginal microbiota structure. Quantificatio

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Stryha, O. A., G. V. Zaychenko, S. I. Savosko, and K. Y. Sorokopud. "THE INVESTIGATION OF PHARMACOLOGICAL PROPERTIES OF VAGINAL GEL WITH RESVERATROL AND HYALURONIC ACID IN CONDITIONS OF EXPERIMENTAL HYPOESTROGENIC STATE IN RATS." Medical Science of Ukraine (MSU) 17, no. 1 (2021): 74–82. http://dx.doi.org/10.32345/2664-4738.1.2021.10.

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Relevance. The menopausal period due to irreversible loss of ovarian function is accompanied by various clinical symptoms and systemic changes. In turn, hormone replacement therapy has a number of contraindications and side effects, so now there is a need to find and create prophylactic and therapeutic agents based on natural compounds that are related to β-estrogen receptors. Vaginal gel with resveratrol and hyaluronic acid can reduce atrophic manifestations of the vaginal mucosa and affect various symptoms of menopause. However, the nature of the effect, dosage, and consequences of long-term

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Mardikasari, Sandra Aulia, Arfian Junior Amir, Aliyah ., et al. "DEVELOPMENT OF METRONIDAZOLE MICROSPONGE INCORPORATED INTO CARBOMER-BASED VAGINAL GEL." Journal of Experimental Biology and Agricultural Sciences 9, Spl-2-ICOPMES_2020 (2021): S241—S247. http://dx.doi.org/10.18006/2021.9(spl-2-icopmes_2020).s241.s247.

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Bacterial vaginosis (BV) is a vaginal infection caused by excessive bacterial growth, thus disrupting the natural balance of bacteria inside the vagina. Metronidazole becomes a drug of choice and a widely prescribed drug for the treatment of BV. However, when applied topically, metronidazole has a low vaginal residence time because of the natural washing mechanism of the vagina. This study aimed to improve the retention time of metronidazole inside the vagina and control its release profile. This study was prepared 4 formulas of gel for metronidazole microsponges with some concentration ratio

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Kumar, Abhijeet, and Raju Agarwal. "Role and efficacy of vaginal dinoprostone gel (PGE2) plus vaginal misoprostol (PGE1) in second trimester termination of pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 3 (2018): 888. http://dx.doi.org/10.18203/2320-1770.ijrcog20180455.

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Background: The addition of dinoprostone gel (PGE2) to standard regimen of second trimester abortion using vaginal misoprostol (PGE1) reduces failure rate and decrease induction abortion time interval. We evaluated the role and efficacy of vaginal dinoprostone gel with vaginal misoprostol in women undergoing second trimester abortion. Objective of present study was to assess the safety and effectiveness of vaginal dinoprostone gel plus vaginal misoprostol for second trimester termination of pregnancy.Methods: This study was a prospective cohort involving 100 women with 12-20 weeks gestation re

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Tiwari, Sarika Sharma, Shailesh K. Gupta, Sumeet Dwivedi, and Raghvendra Dubey. "Formulation and evaluation of in situ herbal gel containing aqueous and methanolic extract of fruits of Quercus infectoria Oliv. for vaginal application." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 495–503. http://dx.doi.org/10.22270/jddt.v8i5.1913.

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Conventional vaginal dosage forms frequently produce leakages and drip. There is a need for the development of innovative vaginal formulation technology that fulfills certain criteria such as desirable product dispersion throughout the vagina, retention for intended intervals, and adequate release of drug. These features can be achieved by the use of bioadhesive based novel delivery systems. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied the site. Formulation and evaluation of one such bioadhesive based novel drug

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Shetty, Ektha M., and Asha Neravi. "A comparative study of vaginal misoprostol, dinoprostone gel, foley catheter, extra amniotic saline infusion along with vaginal misoprostol for induction of labor at term." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 9 (2020): 3683. http://dx.doi.org/10.18203/2320-1770.ijrcog20203840.

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Background: Objective of this study was to study the effect of vaginal misoprostol, dinoprostone gel, foley catheter, extra amniotic saline infusion along with vaginal misoprostol for induction of labor at term on maternal and fetal outcome.Methods: A one-year prospective observational study was conducted in the department of obstetrics and gynecology, SDM College of Medical Science and Hospital, Dharwad. Totally 100 postdated primigravida women with singleton gestation, vertex presentation and intact membrane who were induced with any four methods of induction 1) Tab. misoprostol 25 µg vagina

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Schlievert, Patrick M., Kristi L. Strandberg, Amanda J. Brosnahan, et al. "Glycerol Monolaurate Does Not Alter Rhesus Macaque (Macaca mulatta) Vaginal Lactobacilli and Is Safe for Chronic Use." Antimicrobial Agents and Chemotherapy 52, no. 12 (2008): 4448–54. http://dx.doi.org/10.1128/aac.00989-08.

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ABSTRACT Glycerol monolaurate (GML) is a fatty acid monoester that inhibits growth and exotoxin production of vaginal pathogens and cytokine production by vaginal epithelial cells. Because of these activities, and because of the importance of cytokine-mediated immune activation in human immunodeficiency virus type 1 (HIV-1) transmission to women, our laboratories are performing studies on the potential efficacy of GML as a topical microbicide to interfere with HIV-1 transmission in the simian immunodeficiency virus-rhesus macaque model. While GML is generally recognized as safe by the FDA for

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Janssen, Laura E., Rubin J. T. Verduin, Christianne J. M. de Groot, Martijn A. Oudijk, and Marjon A. de Boer. "The association between vaginal hygiene practices and spontaneous preterm birth: A case-control study." PLOS ONE 17, no. 6 (2022): e0268248. http://dx.doi.org/10.1371/journal.pone.0268248.

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Background Spontaneous preterm birth (SPTB) is a major cause of neonatal morbidity and mortality worldwide and defining its risk factors is necessary to reduce its prevalence. Recent studies have pointed out that bacterial vaginosis, a disturbance in the vaginal microbiome, is associated with SPTB. It is hypothesized that vaginal hygiene practices can alter the vaginal microbiome and are therefore associated with SPTB, but there are no studies investigating this matter. Methods and findings A case-control study was conducted between August 2018 and July 2021 in two affiliated university medica

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Parvinroo, Shirin, Maede Eslami, Heshmatollah Ebrahimi-Najafabadi, and Zahra Hesari. "Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods." Vojnosanitetski pregled, no. 00 (2020): 121. http://dx.doi.org/10.2298/vsp200804121p.

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Background/Aim. Vinegars are of the main international traditional nutraceuticals which have been used as vaginal health protectant due to vagina pH balance maintenance and antimicrobial properties. Since the main used form of vinegar was liquid, it was difficult for vaginal application with low residence time; in this study a vaginal mucoadhesive gel of vinegar was designed. Methods. Xanthan gum (XG) and tragacanth (TG) were utilized as natural gel forming polymers. The effects of Xanthan gum and tragacanth on mucoadhesion strength and drug release of the gel formulations were optimized using

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Nesalin, J. Adlin Jino, and Shafiya Khanum. "CURCUMIN LOADED POLYMERIC MICROSPHERES FOR VAGINAL DELIVERY: FORMULATION DESIGN, IN VITRO EVALUATION, KINETICS AND STABILITY STUDIES." Journal of Pharmaceutical and Scientific Innovation 10, no. 2 (2021): 56–60. http://dx.doi.org/10.7897/2277-4572.102206.

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The main objective of this research is to evaluate a new approach for the preparation of bio adhesive microparticles and to design an innovative vaginal delivery system for curcumin which is able to enhance the drug anticancer activity. Curcumin encapsulated microspheres were prepared by solvent evaporation method. The microspheres were found to be discrete, spherical with free-flowing properties and evaluated for particle size analysis, shape (scanning electron microscopy), drug encapsulation efficiency, FTIR, DSC studies and in vitro release performance. The best selected microsphere formula

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Merriam, Kathryn S., Kristina A. Leake, Mollie Elliot, Michelle L. Matthews, Rebecca S. Usadi, and Bradley S. Hurst. "Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial." International Journal of Endocrinology 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/685281.

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Objective.To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse.Study Design.Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual partners randomized to receive vaginal progesterone gel (Crinone 8% gel, Actavis Inc., USA) or placebo cream. Serum progesterone for both male and female partners were measured 10 hours after intercourse. One week later, subjects were crossed over to receive the opposite formulation. In the third week,

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Ahmad, Farhan, Mohd Alam, Zeenat Khan, Roop Khar, and Mushir Ali. "Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections." Acta Pharmaceutica 58, no. 4 (2008): 407–19. http://dx.doi.org/10.2478/v10007-008-0023-2.

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Development andin vitroevaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infectionsAn acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropyl methylcelullose K4M formed a good combination of bioadhesive polymers to develop the ABBV gel. Monosodium citrate was used as an acid buffering agent to provide acidic pH

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Baloglu, Esra, Andreas Bernkop-Schnürch, Sinem Yaprak Karavana, and Zeynep Ay Senyigit. "Strategies to Prolong the Intravaginal Residence Time of Drug Delivery Systems." Journal of Pharmacy & Pharmaceutical Sciences 12, no. 3 (2009): 312. http://dx.doi.org/10.18433/j3hp41.

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The vagina has been studied as a favorable site for local and systemic delivery of drugs for female-related conditions. There are a large number of vaginal medications on the market and most of them require frequent application due to their short vaginal residence time. A prolonged vaginal residence time of formulations is therefore a key parameter for improved therapeutic efficacy. Promising approaches to prolong the residence time base on mucoadhesion, in- situ sol-gel transition and mechanical fixation. Mucoadhesive drug delivery systems can be tailored to adhere to the vaginal tissue. In-s

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Rochani, Ankit, Vivek Agrahari, Neelima Chandra, et al. "Development and Preclinical Investigation of Physically Cross-Linked and pH-Sensitive Polymeric Gels as Potential Vaginal Contraceptives." Polymers 14, no. 9 (2022): 1728. http://dx.doi.org/10.3390/polym14091728.

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This study explored the development of cross-linked gels to potentially provide a physical barrier to vaginal sperm transport for contraception. Two types of gels were formulated, a physically cross-linked iota-carrageenan (Ci) phenylboronic acid functionalized hydroxylpropylmethyacrylate copolymer (PBA)-based (Ci-PBA) gel, designed to block vaginal sperm transport. The second gel was pH-shifting cross-linked Ci-polyvinyl alcohol-boric acid (Ci-PVA-BA) gel, designed to modulate its properties in forming a viscoelastic, weakly cross-linked transient network (due to Ci gelling properties) on vag

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Destache, Christopher J., Subhra Mandal, Zhe Yuan, et al. "Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model." Antimicrobial Agents and Chemotherapy 60, no. 6 (2016): 3633–39. http://dx.doi.org/10.1128/aac.00450-16.

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Preexposure prophylaxis (PrEP) with 1% tenofovir (TFV) vaginal gel has failed in clinical trials. To improve TFV efficacy in vaginal gel, we formulated tenofovir disoproxil fumarate nanoparticles in a thermosensitive (TMS) gel (TDF-NP-TMS gel). TDF-NPs were fabricated using poly(lactic-co-glycolic acid) (PLGA) polymer and an ion-pairing agent by oil-in-water emulsification. The efficacy of TDF-NP-TMS gel was tested in humanized bone marrow-liver-thymus (hu-BLT) mice. Hu-BLT mice in the treatment group (Rx;n= 15) were administered TDF-NP-TMS gel intravaginally, having TDF at 0.1%, 0.5%, and 1%

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Marques, Carlos Alberto Sá, Paloma de Barros Henrique, Haliny da Silva Magalhães, Tahira Souza Melo, Amouni Mohmoud Mourad, and Jan Carlo Morais Oliveira Bertassoni Delorenzi. "Vaginose bacteriana – avaliação da atividade antimicrobiana seletiva de gel de Schinus terebinthifolia raddi." Brazilian Journal of Health Review 7, no. 2 (2024): e68360. http://dx.doi.org/10.34119/bjhrv7n2-202.

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O microbioma vaginal sofre contínua flutuação durante o ciclo menstrual e após a menopausa. Albert Döderlein foi o primeiro a descrever sobre bactérias produtoras de ácido láctico na cavidade vaginal. Tais bactérias são capazes de inibir o crescimento de microrganismos anaeróbios e patogênicos. Quando há a redução desses lactobacilos, há proliferação de bactérias oportunistas como as do gênero Gardnerella. A vaginose bacteriana (VB) é uma patologia não sexualmente transmissível, caracterizada pelo aumento do número de bactérias anaeróbias e do pH vaginal, ocasionando um corrimento vaginal acin

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Patton, D. L., Y. T. Cosgrove Sweeney, T. D. McCarthy, and S. L. Hillier. "Preclinical Safety and Efficacy Assessments of Dendrimer-Based (SPL7013) Microbicide Gel Formulations in a Nonhuman Primate Model." Antimicrobial Agents and Chemotherapy 50, no. 5 (2006): 1696–700. http://dx.doi.org/10.1128/aac.50.5.1696-1700.2006.

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ABSTRACT Three gel formulations (1%, 3%, and 5% [wt/wt]) of SPL7013, a dendrimer known to have antiviral (anti-human immunodeficiency virus and anti-herpes simplex virus) activities, completed a range of preclinical tests in the pigtailed macaque models for vaginally and rectally applied topical microbicide safety assessments. The vaginal safety profile of the 3% SPL7013 gel formulation was equal to that of the 1% formulation but was superior to that of the 5% formulation. The 3% SPL7013 gel was further evaluated for rectal safety and for antichlamydial efficacy with cervical challenge with Ch

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Mirzaeei, Shahla, Maryam Zangeneh, Firoozeh Veisi, Somayeh Parsa, and Maryam Hematti. "Chlorhexidine, clotrimazole, metronidazole and combination therapy in the treatment of vaginal infections." Journal of Medicine and Life 14, no. 2 (2021): 250–56. http://dx.doi.org/10.25122/jml-2019-0160.

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This was a clinical trial study that aimed to investigate the efficacy of vaginal chlorhexidine gel in the treatment of vulvovaginal candidiasis, bacterial vaginosis, and nonspecific vaginitis. The study population included patients who complained of vaginal discharge and presented to our University Gynecology Clinic. The data were analyzed using the Statistical Package for the Social Sciences (SPSS) software. The student t-test and Mann-Whitney U test were used to analyze the quantitative and ordinal data, respectively. In order to analyze the qualitative data, the Chi-square or Fischer’s exa

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Saunders, Helen, Cass Khan, Thomas D’Hooghe, Thora Björg Magnúsdóttir, Ingrid Klingmann, and Sigrún Hrafnsdóttir. "Efficacy, safety and tolerability of progesterone vaginal pessaries versus progesterone vaginal gel for luteal phase support after in vitro fertilisation: a randomised controlled trial." Human Reproduction 35, no. 2 (2020): 355–63. http://dx.doi.org/10.1093/humrep/dez261.

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Abstract STUDY QUESTION Are progesterone vaginal pessaries 400 mg twice a day (bid) non-inferior to progesterone vaginal gel (90 mg) once a day (od) in the primary endpoint of clinical pregnancy rate after 38 days of luteal phase support in women undergoing in vitro fertilisation (IVF)? SUMMARY ANSWER Non-inferiority of progesterone vaginal pessaries 400 mg bid to progesterone 8% vaginal gel (90 mg od) was shown for clinical pregnancy rate after 38 days of luteal phase support. WHAT IS KNOWN ALREADY To maximise successful embryo transfer after IVF, additionally administered progesterone is use

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Hiba, Salmo M. "Investigation the effect of different concentrations of carbomer & Co solvent propylene glycol on the releasing process of tinidazole from vaginal aqueous gel." Al Mustansiriyah Journal of Pharmaceutical Sciences 3, no. 1 (2006): 75–85. http://dx.doi.org/10.32947/ajps.v3i1.411.

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The ability of local mucoadhesive vaginal aqueous gel to deliver the antibacterial, antiprotozoal tinidazole (TND) to vaginal endolayers is dependent on its releasing out of the drug from vehicle to the mucosal layer of the vagina and then exert its local effect. This depends upon the physicochemical properties of the drug, vehicle & the composition of the releasing medium used.The effect of different concentration of carbomer 941(0.5, 1&2% w/w) on the release of TND (2%w/w) from the aqueous gel base in absence & presence of various concentration of propylene glycol (PG) to the sti

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Taran, O. A., O. V. Bulavenko, D. G. Konkov, and T. V. Lobastova. "The clinical experience for optimizing the reparative processes of the cervix after destructive surgical interventions." HEALTH OF WOMAN, no. 3(139) (April 30, 2019): 38–42. http://dx.doi.org/10.15574/hw.2019.139.38.

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The objective: to evaluate the therapeutic approach in order to improve regenerate the epithelium of the cervical mucosa and restore of the vaginal biocenosis after laser vaporization in women of reproductive age with CIN I with including the vaginal gel which consist of decametoxinum and hyaluronic acid. Materials and methods. 60 women of reproductive age were examined with CIN І, confirmed by histological examination, which underwent laser vaporization. The main clinical group (n=30), for patients were prescribed 5 ml vaginal gel which consist of decametoxinum and hyaluronic acid (Ginodek®)

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&NA;. "Dapivirine vaginal gel well tolerated." Reactions Weekly &NA;, no. 1265 (2009): 3. http://dx.doi.org/10.2165/00128415-200912650-00006.

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Varuni, Sharma, and Shukla Navin. "The Efficacy of Chlorhexidine Gel in Managing Vaginal Infections." International Journal of Pharmaceutical and Clinical Research 14, no. 5 (2022): 790–96. https://doi.org/10.5281/zenodo.13830394.

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<strong>Introduction:</strong> Vaginal infections are prevalent among the population. It complicates pregnancy, lactation and also deteriorates the quality of life. There are antifungal and antimicrobial medications, which are more precise in their therapy, are already available for such infections. a novel bio-adhesive vaginal gel with % chlorhexidine gluconate was recently developed using a patented technique. This formulation provides for a longer release of Chlorhexidine throughout time because of its bio-adhesive properties it is important to investigate this medication in vaginal in

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Lima, Sonia M. Rolim Rosa, Silvia Saito Yamada, Benedito Fabiano Reis, Sostenes Postigo, Maria Antonieta L. Galvão da Silva, and Tsutomu Aoki. "Effective treatment of vaginal atrophy with isoflavone vaginal gel." Maturitas 74, no. 3 (2013): 252–58. http://dx.doi.org/10.1016/j.maturitas.2012.11.012.

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Wain, A. M. "Metronidazole vaginal gel 0.75% (MetroGel-Vaginal�): A brief review." Infectious Diseases in Obstetrics and Gynecology 6, no. 1 (1998): 3–7. http://dx.doi.org/10.1002/(sici)1098-0997(1998)6:1<3::aid-idog2>3.0.co;2-0.

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Campaner, Adriana Bittencourt, Ana Carolina Alves Rosário Sica, Flavia Salomão d’ Avila Curi, Giulia Marchetti, Grazielle Suhett Dias, and Bianca Luise Teixeira. "In vivo assessment of the effect of gel containing lactic acid and glycogen on vaginal microbiota and pH of asymptomatic women of reproductive age." PLOS One 20, no. 4 (2025): e0321737. https://doi.org/10.1371/journal.pone.0321737.

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Background Vaginal dysbiosis is considered a risk factor for the development of gynecological and obstetric complications. This study aimed to evaluate the effects of vaginal gel containing lactic acid on vaginal pH, microbiota composition, and Candida species in asymptomatic women of reproductive age. Methods: 55 menstruating women, with no gynecological complaints, participated in the study, using a gel containing lactic acid twice a week, for 8 weeks. Assessments were conducted before and after the intervention, including measurements of vaginal pH, Nugent score, vaginal microbiota characte

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Ayala, Salomón, Juan Rojas, David Díaz, José Juárez, and Carlos Delgado. "Evaluación de la toxicidad vaginal de Croton lechleri en conejas." Anales de la Facultad de Medicina 71, no. 2 (2011): 83. http://dx.doi.org/10.15381/anales.v71i2.78.

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Objetivo: Evaluar la toxicidad vaginal de una preparación en gel de Croton lechleri en conejas. Diseño: Estudio experimental. Institución: Centro de Investigación de Bioquímica y Nutrición Alberto Guzmán Barrón, Instituto de Investigaciones Clínicas, Instituto de Patología de la Facultad de Medicina, y Facultad de Farmacia, Universidad Nacional Mayor de San Marcos, Lima, Perú. Material biológico: Resina de Croton lechleri y conejos hembras, blancos, Nueva Zelanda. Métodos: Los animales fueron distribuidos en tres grupos (n=5): I. Control, vehículo; II, C. lechleri 1%; y III, C. lechleri 5%; lo

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Pereira, Lara E., Pedro M. M. Mesquita, Anthony Ham, et al. "Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques." Antimicrobial Agents and Chemotherapy 60, no. 3 (2015): 1393–400. http://dx.doi.org/10.1128/aac.02201-15.

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We evaluated thein vivopharmacokinetics and used a complementaryex vivococulture assay to determine the pharmacodynamics of IQB3002 gel containing 1% IQP-0528, a nonnucleoside reverse transcriptase inhibitor (NNRTI), in rhesus macaques (RM). The gel (1.5 ml) was applied vaginally to 6 simian-human immunodeficiency (SHIV)-positive female RM. Blood, vaginal fluids, and rectal fluids were collected at 0, 1, 2, and 4 h. RM were euthanized at 4 h, and vaginal, cervical, rectal, and regional lymph node tissues were harvested. Anti-human immunodeficiency virus (HIV) activity was evaluatedex vivoby co

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Vaidya, Dakshaja, Arun H. Nayak, Shweta Khade, and Smurti Kamble. "Primary amenorrhea with transverse vaginal septum." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 12 (2024): 3751–55. http://dx.doi.org/10.18203/2320-1770.ijrcog20243618.

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Transverse vaginal septum is a rare congenital anomaly with an incidence of 1:2100 due to incomplete fusion of mullerian duct and the urogenital sinus component of the vagina. Surgical management of the transverse vaginal septum is based on its thickness and its location in the vagina. A 13-year-old girl presented with cyclical abdominal pain for 3 months without attaining menarche. Examination revealed a blind ending vagina. Ultrasound and MRI revealed hematocoplos and hematometra. Septum was located 2.5 cm away from vaginal introitus, of 3.4 mm thickness. Vaginal septal resection was perform

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Chougala, Ashwini, and Arati Mahishale. "A Randomized Clinical Trial to evaluate the Effect of Therapeutic Ultrasound and Low-level Laser Therapy on Perineal Pain following Vaginal Delivery with Episiotomy." Journal of South Asian Federation of Obstetrics and Gynaecology 7, no. 3 (2015): 152–56. http://dx.doi.org/10.5005/jp-journals-10006-1346.

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ABSTRACT Background and objectives Vaginal delivery has an enormous amount of pressure on the perineum, the area between vagina and anus, which must stretch to accommodate the baby's head during its passage through the birth canal. During childbirth, the perineum may tear or the obstetrician may decide to incise to make wider opening for baby's head to pass, a procedure called as episiotomy. The area of episiotomy may be uncomfortable and painful for several days. The present study aimed to evaluate the effect of therapeutic ultrasound and low-level laser therapy (LLLT) on perineal pain follow

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Kalpana, Priya Sharma, Amit Kaushik, Priyanka Rao, Neelam Swaroop, and Neetu Singh. "A comparative study of low dose vaginal misoprostol and dinoprostone gel for induction of labour at term of pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 1 (2016): 207. http://dx.doi.org/10.18203/2320-1770.ijrcog20164659.

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Background: The aim of this study was to compare the low dose of vaginal misoprostol and dinoprostone gel for the induction of labour at term of pregnancy.Methods: The study was conducted on 90 women, randomized into two groups, each group having 45 women. First group received misoprostol per vaginally and second group received the dinoprostone gel. The duration of induction to delivery interval, mode of delivery and complications related to labour or foetus were recorded.Results: The mean induction to delivery interval in the misoprostol group was 11.68 ± 4.49 hours and in the dioprostone gel

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Kong, Lin, Jie Kong, Zhihong Chai та ін. "Recombinant Interferon α-2B Gel Combined with Lactobacillus as a Vaginal Capsule in Patients with Cervical High-Risk Human Papillomavirus". Current Topics in Nutraceutical Research 21, № 1 (2022): 47–52. http://dx.doi.org/10.37290/ctnr2641-452x.21:47-52.

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This study was performed to investigate the effects of Lactobacillus vaginal capsules combined with recombinant human interferon α-2b gel on clinical efficacy, vaginal microbial function indicators, vaginal microecological balance, inflammation levels, and drug safety in patients with persistent cervical high-risk human papillomavirus infection. Patients with human papillomavirus infection (n = 128) were randomly divided into control and observation groups of equal size. Patients in the control group were treated with recombinant human interferon α-2b gel alone. Patients in the observation gro

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Jitesh, Satija, Bhadra Avishek, Biswas Rumela, Kumar Mistri Pallab, and Talukdar Vipanchi. "Effect of Vaginal PH on Efficacy of Dinoprostone Gel for Labour Induction: A Cross-Sectional Study in Eastern India." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 276–81. https://doi.org/10.5281/zenodo.14034263.

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<strong>Objectives: </strong>To evaluate whether vaginal pH alters the efficacy of dinoprostone gel for induction of labor, to find out whether vaginal pH affects cervical ripening and Bishop’s score prior to induction, and to evaluate whether parity or age affects vaginal pH. <strong>Materials and Methods:</strong> This prospective study was conducted at a tertiary care center in Kolkata for a period of 18 months, and included 200 women undergoing induction with dinoprostone gel. Participants were categorized based on vaginal pH: Group A (pH ≤4.5) and Group B (pH >4

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Zaychenko, Ganna, Olena Stryga, Oksana Sinitsyna, et al. "Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms." Molecules 27, no. 15 (2022): 4916. http://dx.doi.org/10.3390/molecules27154916.

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Phytoestrogen resveratrol (R) has been demonstrated to benefit human reproductive health. However, R bioavailability and pharmacokinetics are still problematic under oral supplementation. We used an experimental vaginal gel with R and hyaluronic acid (HA) to improve bioavailability and pharmacokinetic properties. The study aimed to assess the impact of vaginal R-HA gel on the reproductive system in ovariectomized rats. Methods: The study was carried out on Wistar female rats. It investigated the body weight, tail temperature, vaginal pH, estrogen and progesterone blood levels, and immunohistoc

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Md, Tanweer A. Syed, A. Qureshi, Seyed Ali Ahmad, and Shahida M. Ali. "Management of intravaginal warts in women with 5-fluorouracil (1%) in vaginal hydrophilic gel: a placebo-controlled double-blind study." International Journal of STD & AIDS 11, no. 6 (2000): 371–74. http://dx.doi.org/10.1258/0956462001916074.

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The purpose of this placebo-controlled, double-blind study was to determine the safety, tolerability and clinical efficacy of 5-fluorouracil (1%) in a vaginal hydrophilic gel (hydroxyethylcellulose, 1%) to cure intravaginal papillomas in women. Pre-selected, 60 women ranging between 18 and 50 years of age (mean 24.6), having 312 vaginal condylomas (mean 5.2) joined the study. The diagnosis of human papillomavirus (HPV) was established with clinical, histopathological and polymerase chain reaction (PCR) techniques. Subjects were randomized into 2 parallel groups. Each patient was allocated a pr

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Sukhanova, A. A., V. V. Sumenko, and R. R. Tkachuk. "Alternative possibilities of hyaluronic acid in genitourinary symptoms treatment." REPRODUCTIVE ENDOCRINOLOGY, no. 59 (July 22, 2021): 92–100. http://dx.doi.org/10.18370/2309-4117.2021.59.92-100.

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Research objective: to evaluate the clinical efficacy of vaginal gel with hyaluronic acid Revitaxa gel in comparison with synthetic estrogen-like topical agent in the treatment of women with genitourinary syndrome, to determine the recurrence rate of atrophic changes as a result of these schemes.Materials and methods. The study included 60 women with genitourinary manifestations and atrophic changes of the vaginal mucosa and cervical epithelium. Clinical, cytological and colposcopic studies were performed to analyze the vaginal epithelium, vaginal microbiocenosis and vaginal tissues. All women

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Boregowda, Sateesha S., Sadanand R. Maggidi, Rajamma A. Jayaramu, Nethravathi Puttegowda, and Nikhat Parbin. "Development of an In situ Gel Polymer Composite for Local and Sustained Delivery of Drugs in Vaginal Cavity." Drug Delivery Letters 9, no. 3 (2019): 211–21. http://dx.doi.org/10.2174/2210303109666190226152857.

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Objective: The present research work is aimed at the development of an in situ gel polymer composite to provide local and sustained delivery of therapeutic agents in the vaginal cavity. Administration of medicated gel into a vaginal cavity is very complicated, inconvenient and needs expert assistance. There is a chance of expulsion of liquid formulation from site of application, leads to poor therapeutic efficacy. The effective drug delivery system for the vaginal cavity should be of liquid for application and gel to reside in the cavity. Methods: In situ gel composed of chitosan (0.8%) cross-

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T. Tawfeeq, Alaa, Muayad S. Abbood, and Mufeda A. Jwad. "The Comparison Between The Effect of Different Medical Drugs used To Improve Endometrial Receptivity in patients with Thin Poorly Vascularized Endometrium." IraQi Journal of Embryos and Infertility Researches 13, no. 2 (2023): 99–115. http://dx.doi.org/10.28969/ijeir.v13.i2.r8.23.

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In a perfect world, the peak of receptivity of the endometrial lining would occur simultaneously with the entry into the uterine cavity of a healthy blastocyst, which would then be able to adhere, attach, invade, and develop protected until the time of delivery. This would be the ideal scenario. The study was carried out on 200 infertile women who have thin , poorly vascularized endometrium, those patients were divided into five groups ; 40 patients in each group, group A received esterofem oral, group B received vagifem vaginal tablets, group C received sildenafil citrate gel, group D receive

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Powar, P. V., and K. Kanade. "FORMULATION AND IN VITRO EVALUATION OF GEL BASED POLYHERBAL VAGINAL WASH." INDIAN DRUGS 55, no. 08 (2018): 25–30. http://dx.doi.org/10.53879/id.55.08.10696.

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Vaginal Infection is quite common in India, a multi-city study estimated that more than 90% of women between the ages 25 and 35 suffer with vaginal infection and 93% do not follow the best personal hygiene practices. The vaginal yeast infection is caused by Candida albicans. Which is characterized by Itching, irritation in tissues at the vaginal opening (vulva), burning sensation, redness /swelling of the vulva, vaginal pain ,soreness, vaginal rash, watery vaginal discharge . The objective of the present study was to develop poly-herbal vaginal wash for prevention of Candida albicans infection

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Barnable, Patrick, Giulia Calenda, Thierry Bonnaire, et al. "MIV-150/Zinc Acetate Gel Inhibits Cell-Associated Simian-Human Immunodeficiency Virus Reverse Transcriptase Infection in a Macaque Vaginal Explant Model." Antimicrobial Agents and Chemotherapy 59, no. 7 (2015): 3829–37. http://dx.doi.org/10.1128/aac.00073-15.

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ABSTRACTThe transmission of both cell-free and cell-associated immunodeficiency viruses has been demonstrated directly in multiple animal species and possibly occurs in humans, as suggested by genotyping of the infecting human immunodeficiency virus (HIV) in acutely infected women and in semen from their partners. Therefore, a microbicide may need to block both mechanisms of HIV transmission to achieve maximum efficacy. To date, most of the preclinical evaluation of candidate microbicides has been performed using cell-free HIV. New models of mucosal transmission of cell-associated HIV are need

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Jodar, Aaron, Luis Soto, Eva Turell, and Javier Cortés. "Monotherapy With a Non-Hormonal Centella Asiatica, Hyaluronic Acid, and Prebiotic-Based Vaginal Gel in Women With Bacterial Vaginosis: Case Series." Clinical Medicine Insights: Case Reports 16 (January 2023): 117954762311572. http://dx.doi.org/10.1177/11795476231157244.

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Bacterial vaginosis (BV) affects nearly one-third of women worldwide and may predispose patients to sexually transmitted infections or pelvic inflammatory disease. Currently recommended treatment is based on antibiotic use, which poses problems such as antibiotic resistance and the development of secondary vaginal candidiasis. Palomacare® is a non-hormonal vaginal gel containing hyaluronic acid, Centella asiatica and prebiotics, with repairing and moisturizing properties used for dysbiosis healing as an adjuvant treatment. A series of 3 cases using the vaginal gel as a monotherapy showed that

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Saleem, Faiqa, Munazza Malik, Muhammad Sohaib Shahid, and Muhammad Tayyab. "BACTERIAL VAGINOSIS;." Professional Medical Journal 24, no. 02 (2017): 252–57. http://dx.doi.org/10.29309/tpmj/2017.24.02.520.

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In women of reproductive age bacterial vaginosis is a most common polymicrobialdisease and is the leading reason for vaginal discharge in this age group. Additionally itis further linked with sizeable disease burden of community problem in terms of infectiouscomplications. Clindamycin vaginal cream and metronidazole vaginal gel are effective in themanagement of vaginal infections caused by multi bacteria. Objectives: To compare thetherapeutic efficacy of Metronidazole vaginal gel and clindamycin vaginal cream as modality oftreatment for bacterial vaginosis. Study Design: Randomized control tri

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Andrade, Ana Ochoa, María Emma Parente, and Gastón Ares. "Screening of mucoadhesive vaginal gel formulations." Brazilian Journal of Pharmaceutical Sciences 50, no. 4 (2014): 931–41. http://dx.doi.org/10.1590/s1984-82502014000400029.

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Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum). The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests) and the effect of dilution with simulated vaginal fluid (SVF) on spreadability. Res

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