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Journal articles on the topic 'Vaginal immunization'

Author: Grafiati
Published: 14 March 2023
Last updated: 31 July 2025

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1

Parr, Earl L., and Margaret B. Parr. "Immunoglobulin G, Plasma Cells, and Lymphocytes in the Murine Vagina after Vaginal or Parenteral Immunization with Attenuated Herpes Simplex Virus Type 2." Journal of Virology 72, no. 6 (1998): 5137–45. http://dx.doi.org/10.1128/jvi.72.6.5137-5145.1998.

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ABSTRACT This investigation evaluated immunity to vaginal herpes simplex virus type 2 (HSV-2) infection after local or parenteral immunization with attenuated HSV-2. Vaginal immunization induced sterilizing immunity against challenge with a high dose of wild-type virus, whereas parenteral immunizations protected against neurologic disease but did not entirely prevent infection of the vagina. Vaginal immunization caused 86- and 31-fold increases in the numbers of immunoglobulin G (IgG) plasma cells in the vagina at 6 weeks and 10 months after immunization, whereas parenteral immunizations did n
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2

Johansson, Eva-Liz, Carola Rask, Margareta Fredriksson, Kristina Eriksson, Cecil Czerkinsky, and Jan Holmgren. "Antibodies and Antibody-Secreting Cells in the Female Genital Tract after Vaginal or Intranasal Immunization with Cholera Toxin B Subunit or Conjugates." Infection and Immunity 66, no. 2 (1998): 514–20. http://dx.doi.org/10.1128/iai.66.2.514-520.1998.

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ABSTRACT We studied the antibody response including antibody-secreting cells (ASC) in the female genital tract of mice after mucosal immunizations with the recombinant B subunit of cholera toxin (rCTB) perorally, intraperitoneally, vaginally, and intranasally (i.n.). The strongest genital antibody responses as measured with a novel perfusion-extraction method were induced after vaginal and i.n. immunizations, and these routes also gave rise to specific immunoglobulin A (IgA) and IgG ASC in the genital mucosa. Specific ASC in the iliac lymph nodes, which drain the female genital tract, were see
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3

Wira, C. R., and C. P. Sandoe. "Specific IgA and IgG antibodies in the secretions of the female reproductive tract: effects of immunization and estradiol on expression of this response in vivo." Journal of Immunology 138, no. 12 (1987): 4159–64. http://dx.doi.org/10.4049/jimmunol.138.12.4159.

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Abstract Uterine and vaginal secretions collected from intact adult female rats were analyzed to determine whether immunization at sites distal to the reproductive tract had any effect on the presence of specific IgA and IgG antibodies in genital tract secretions. Peyer's patch and i.p. immunization and boost with sheep red blood cells (SRBC) stimulated the appearance of specific IgA antibodies in uterine and vaginal secretions of uterine-ligated animals. IgG antibodies were also induced in uterine but not in vaginal secretions. In contrast, subcutaneous immunization and boost elicited a weak
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4

Eriksson, Kristina, Marianne Quiding-Järbrink, Jacek Osek, et al. "Specific-Antibody-Secreting Cells in the Rectums and Genital Tracts of Nonhuman Primates following Vaccination." Infection and Immunity 66, no. 12 (1998): 5889–96. http://dx.doi.org/10.1128/iai.66.12.5889-5896.1998.

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ABSTRACT To determine optimal strategies to induce specific-antibody-secreting cells (specific ASC) in the rectal and vaginal mucosae, we immunized monkeys with a prototype mucosal immunogen, cholera toxin (CT), given locally or via gastric or parenteral administration. Repeated rectal or vaginal CT immunizations induced strong mucosal and systemic ASC responses. The mucosal responses were, however, confined to the immunization sites and comprised high levels of both specific antitoxin immunoglobulin A (IgA) and IgG. Large numbers of specific IgA and IgG ASC were detected in cell suspensions f
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5

Wang, Jie, Wenbo Li, Ning Li, and Beinan Wang. "Immunization with Multiple Virulence Factors Provides Maternal and Neonatal Protection against Group B Streptococcus Serotypes." Vaccines 11, no. 9 (2023): 1459. http://dx.doi.org/10.3390/vaccines11091459.

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Group B streptococcus (GBS) commonly colonizes the vaginal tract and is a leading cause of life-threatening neonatal infections and adverse pregnancy outcomes. No effective vaccine is clinically available. Conserved bacterial virulence factors, including those of GBS, have been employed as vaccine components. We investigated serotype-independent protection against GBS by intranasal immunization with six conserved GBS virulence factors (GBSV6). GBSV6 induced systemic and vaginal antibodies and T cell responses in mice. The immunity reduced mouse mortality and vaginal colonization by various GBS
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6

Livingston, Julie B., Shan Lu, Harriet Robinson, and Deborah J. Anderson. "Immunization of the Female Genital Tract with a DNA-Based Vaccine." Infection and Immunity 66, no. 1 (1998): 322–29. http://dx.doi.org/10.1128/iai.66.1.322-329.1998.

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ABSTRACT Vaccines are being sought for contraception and the prevention of sexually transmitted diseases. However, progress is slow in this area largely because of lack of information on induction of protective immune responses in genital tract mucosa. In this study, we investigated whether in vivo transfection with a model DNA-based antigen delivered by gene gun technology would induce an antibody response detectable in vaginal secretions. Female rats were immunized with plasmids encoding human growth hormone (HGH) under the control of a cytomegalovirus promoter (pCMV/HGH) via vaginal mucosa
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7

Wang, Yichuan, Yongjun Sui, Jason Steel, John Morris, and Jay Berzofsky. "Vaginal type-II mucosa acts as an inductive site during the generation of primary CD8+ T cell mucosal immune responses (P3186)." Journal of Immunology 190, no. 1_Supplement (2013): 124.4. http://dx.doi.org/10.4049/jimmunol.190.supp.124.4.

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Abstract It is widely believed that primary immune induction in type-II mucosa (vagina, mouth & cornea) occurs in the draining LNs due to a lack of mucosa-associated lymphoid tissue. In this process, naïve T cells located in the draining LNs are primed by antigen (Ag)-bearing dendritic cells migrating from the Ag-exposed mucosa. Primed T cells then travel to the mucosal site through the bloodstream. In contrast to this paradigm, we show that vaginal mucosa itself can act as an immune inductive site for generation of primary CD8+ T cell mucosal immunity. As evidence, we found that naïve C
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8

Medaglini, Donata, Marco R. Oggioni, and Gianni Pozzi. "Vaginal Immunization with Recombinant Gram-Positive Bacteria." American Journal of Reproductive Immunology 39, no. 3 (1998): 199–208. http://dx.doi.org/10.1111/j.1600-0897.1998.tb00354.x.

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9

Uehling, David T., Walter J. Hopkins, Jean Jensen, and Edward Balish. "Vaginal Immunization Against Induced Cystitis in Monkeys." Journal of Urology 137, no. 2 (1987): 327–29. http://dx.doi.org/10.1016/s0022-5347(17)44015-8.

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10

Hogge, Christopher James, Sabrina Helmold Hait, Gospel Enyindah-Asonye, Zuena Mushtaq, Tanya Hoang, and Marjorie Robert-Guroff. "Replicating Ad-SIV recombinant vaccines elicit mucosal humoral immunity in rhesus macaques at both rectal and vaginal sites with potential protective efficacy." Journal of Immunology 202, no. 1_Supplement (2019): 72.2. http://dx.doi.org/10.4049/jimmunol.202.supp.72.2.

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Abstract Humoral immunity, especially at mucosal sites, is important for preventing HIV acquisition. Replicating adenovirus (Ad)-SIV priming/gp120 boosting regimens have elicited mucosal immunity and protection against intrarectal SIV challenge in Rhesus macaques. Here we investigated mucosal responses in female macaques primed intranasally/orally, then intratracheally with Ad5hr-SIV(Env/gag/nef), boosted twice intramuscularly with SIV gp120, and challenged vaginally with repeated low-dose SIVmac251. Vaginal washes and rectal swabs and biopsies were obtained 3-weeks post-immunizations. gp120-s
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11

Hymel, Terri J., Joseph Sherman, Sandra K. Pope, and Kelly J. Kelleher. "Inadequate Immunizations." Clinical Pediatrics 32, no. 3 (1993): 156–60. http://dx.doi.org/10.1177/000992289303200306.

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Immunizations are cost-effective measures for assuring public health. However, recent outbreaks of measles, mumps, and pertussis underscore the inadequacy of current immunization programs. A model identifying those children who are likely to be inadequately immunized could focus the use of limited health funds. A retrospective examination of the medical charts of 101 children in a large inner-city clinic was undertaken to determine if specific factors were associated with inadequate immunization status. Fifty percent of the children were inadequately immunized by 18 months of age (no measles-m
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12

Jersey, James de, Lyn A. Hinds та Mark P. Bradley. "Regulation of reproductive tract immunoglobulins by oestradiol-17β in the European Red Fox (Vulpes vulpes)". Reproduction, Fertility and Development 9, № 5 (1997): 531. http://dx.doi.org/10.1071/r97035.

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The effect of the ovarian hormone, oestradiol-17β, on reproductive tract immunity in the female fox was investigated. Reproductive tract antibody responses were induced by either Peyer’s patch immunization with a recombinant fox sperm protein, or by oral immunization with live, attenuated Salmonella typhimurium. The effect of exogenous oestradiol-17β or the stage of the oestrous cycle on reproductive tract immunity was assessed. The secretion of specific vaginal IgA, but not vaginal IgG, antibodies was reduced by exogenous treatment with oestradiol-17β, while both specific vaginal IgA and vagi
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13

Minesso, Sergio, Amienwanlen Eugene Odigie, Valentina Franceschi, et al. "A Simple and Versatile Method for Ex Vivo Monitoring of Goat Vaginal Mucosa Transduction by Viral Vector Vaccines." Vaccines 12, no. 8 (2024): 851. http://dx.doi.org/10.3390/vaccines12080851.

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Goat may represent a valid large animal model for human pathogens and new vaccines testing. Appropriate vaccine administration is a critical component of a successful immunization program. The wrong route of administration may reduce the efficacy of the vaccine, whereas the proper administration strategy can enhance it. Viral vectors have been employed successfully for goat and sheep immunization; however, no data concerning the vaginal route are available. A viral vector’s ability to transduce the site of inoculation is of primary interest. In this study, a fast and reliable ex vivo assay for
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14

Gillgrass, Amy E., Vera A. Tang, Kate M. Towarnicki, Kenneth L. Rosenthal, and Charu Kaushic. "Protection against Genital Herpes Infection in Mice Immunized under Different Hormonal Conditions Correlates with Induction of Vagina-Associated Lymphoid Tissue." Journal of Virology 79, no. 5 (2005): 3117–26. http://dx.doi.org/10.1128/jvi.79.5.3117-3126.2005.

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ABSTRACT The present study was undertaken to examine the effect of the hormonal environment on immunization with an attenuated strain of herpes simplex virus type 2 (HSV-2 TK−) and subsequent protection against challenge. Ovariectomized mice were administered saline (S; control), estradiol (E2), progesterone (P4), or a combination of estradiol and progesterone (E+P) and immunized intravaginally (IVAG) with HSV-2 TK−. Three weeks later, the immunized mice were challenged IVAG with wild-type HSV-2. Mice that were immunized following E treatment were not protected, whereas complete protection aga
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15

Tucker, Kiersten, Veronica Dave, and Jennifer M. Lund. "Mucosal vaccination provides protection from HSV-2 infection and disease." Journal of Immunology 208, no. 1_Supplement (2022): 64.07. http://dx.doi.org/10.4049/jimmunol.208.supp.64.07.

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Abstract Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that is estimated to infect around 23 million people per year. Despite high global prevalence, there are not any approved vaccines that are therapeutic or preventative. Most vaccines that we use today rely on injecting antigens intramuscularly in order to elicit an adaptive immune response. However, given that most pathogens gain entry to the host across barrier surfaces, a focus on eliciting mucosal immunity may enhance protection; vaccine-induced local immunity at the site of first pathogen exposure may have the
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16

Xiang, Zhi Quan, Susanna Pasquini, and Hildegund C. J. Ertl. "Induction of Genital Immunity by DNA Priming and Intranasal Booster Immunization with a Replication-Defective Adenoviral Recombinant." Journal of Immunology 162, no. 11 (1999): 6716–23. http://dx.doi.org/10.4049/jimmunol.162.11.6716.

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Abstract Mice immunized through different routes such as i.m., intradermally, or intratracheally with a DNA vaccine to rabies virus developed high titers of serum Ab but only borderline levels of mucosal Abs determined from vaginal secretions. DNA vaccines given by either route enhanced vaginal IgA and IgG2a secretion upon a subsequent intranasal booster immunization with an E1-deleted adenoviral recombinant expressing the same Ag of rabies virus. DNA vaccine priming reduced the Ab response to the adenoviral Ags and counterbalanced the impaired B cell response to the rabies virus Ag expressed
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17

Staats, H. F., W. G. Nichols, and T. J. Palker. "Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A)." Journal of Immunology 157, no. 1 (1996): 462–72. http://dx.doi.org/10.4049/jimmunol.157.1.462.

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Abstract To optimize mucosal immune responses to the HIV-1 peptide vaccine candidate T1SP10 MN(A), we intranasally immunized BALB/c and C57BL/6 mice with C4/V3 HIV-1 peptide together with the mucosal adjuvant cholera toxin (CT). Four doses over a 4-wk period resulted in peak serum anti-peptide IgG titers of > 1:160,000 in BALB/c mice and > 1:520,000 in C57BL/6 mice, and significant levels (>1:30,000) persisted in both strains of mice for longer than 6 mo. Furthermore, intranasal immunization with peptide and CT induced serum IgG reactivity to HIV-1 gp120 and HIV-1(MN) neut
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18

Shillova, Nita, Savannah E. Howe, Besmir Hyseni, Deahneece Ridgell, Derek J. Fisher, and Vjollca Konjufca. "Chlamydia-Specific IgA Secretion in the Female Reproductive Tract Induced via Per-Oral Immunization Confers Protection against Primary Chlamydia Challenge." Infection and Immunity 89, no. 1 (2020): e00413-20. http://dx.doi.org/10.1128/iai.00413-20.

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ABSTRACTChlamydia trachomatis is an obligate intracellular pathogen that causes sexually transmitted disease. In women, chlamydial infections may cause pelvic inflammatory disease (PID), ectopic pregnancy, and infertility. The role of antibodies in protection against a primary Chlamydia infection is unclear and was a focus of this work. Using the C. muridarum mouse infection model, we show that intestinal mucosa is infected via intranasal (i.n.) or per-oral (p.o.) Chlamydia inoculation and that unlike the female reproductive tract (FRT) mucosa, it halts systemic Chlamydia dissemination. Moreov
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19

Dupuy, Catherine, Dominique Buzoni-Gatel, Antoine Touzé, Daniel Bout, and Pierre Coursaget. "Nasal Immunization of Mice with Human Papillomavirus Type 16 (HPV-16) Virus-Like Particles or with the HPV-16 L1 Gene Elicits Specific Cytotoxic T Lymphocytes in Vaginal Draining Lymph Nodes." Journal of Virology 73, no. 11 (1999): 9063–71. http://dx.doi.org/10.1128/jvi.73.11.9063-9071.1999.

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ABSTRACT Human papillomavirus type 16 (HPV-16) infects the genital tract and is closely associated with the development of cervical cancer. HPV-16 initiates infection at the genital mucosal surface; thus, mucosal immune responses are likely to contribute to defense against HPV-16 infection. However, little information is available regarding the induction of immune responses in the genital tract mucosa. In this study, we evaluated the potential of intranasally administered papillomavirus vaccines to elicit both systemic and vaginal immune responses. HPV-16 virus-like particles (VLPs) produced b
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20

Kutzler, Michele, Noshin Kathuria, Ashley Curatola, et al. "CCR10 expression is required for immunogenicity of a HIV-1env DNA vaccine encoding CCL28 to enhance HIV-1env-specific IgG and IgA at relevant mucosal sites (VAC7P.986)." Journal of Immunology 192, no. 1_Supplement (2014): 141.31. http://dx.doi.org/10.4049/jimmunol.192.supp.141.31.

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Abstract Development of a vaccine that drives anti-viral mucosal B cell responses is critical for protection against HIV-1 infection. It is currently unknown whether triggering CCR10/CCL28 pathways in a DNA-based vaccine results in induction of HIV-1env specific B cell immunity at mucosal sites of infection. We hypothesized that co-immunization with HIV-1env/CCL28 molecular adjuvant would augment B cell responses at gastrointestinal and vaginal sites and require CCR10. CCL28 co-immunized WT mice displayed a significant enhancement of HIV-1env specific antibody titers in serum, feces and vagina
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21

Matchett, William E., Goda Baddage Rakitha Malewana, Haley Mudrick, Michael J. Medlyn, and Michael A. Barry. "Genetic Adjuvants in Replicating Single-Cycle Adenovirus Vectors Amplify Systemic and Mucosal Immune Responses against HIV-1 Envelope." Vaccines 8, no. 1 (2020): 64. http://dx.doi.org/10.3390/vaccines8010064.

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Most infections occur at mucosal surfaces. Providing a barrier of protection at these surfaces may be a useful strategy to combat the earliest events in infection when there are relatively few pathogens to address. The majority of vaccines are delivered systemically by the intramuscular (IM) route. While IM vaccination can drive mucosal immune responses, mucosal immunization at intranasal (IN) or oral sites can lead to better immune responses at mucosal sites of viral entry. In macaques, IN immunization with replicating single-cycle adenovirus (SC-Ads) and protein boosts generated favorable mu
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22

Whaley, K. J., L. Zeitlin, R. A. Barratt, T. E. Hoen, and R. A. Cone. "Passive Immunization of the Vagina Protects Mice against Vaginal Transmission of Genital Herpes Infections." Journal of Infectious Diseases 169, no. 3 (1994): 647–49. http://dx.doi.org/10.1093/infdis/169.3.647.

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23

Klavinskis, L. S., L. A. Bergmeier, L. Gao, et al. "Mucosal or targeted lymph node immunization of macaques with a particulate SIVp27 protein elicits virus-specific CTL in the genito-rectal mucosa and draining lymph nodes." Journal of Immunology 157, no. 6 (1996): 2521–27. http://dx.doi.org/10.4049/jimmunol.157.6.2521.

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Abstract The major routes of HIV transmission are through the rectal and cervico-vaginal mucosa. To prevent dissemination of HIV to the regional lymph nodes (LNs), an effective vaccine may need to stimulate CTL in the rectal or genital tract and the draining LNs. We report that mucosal immunization by the recto-oral and vagino-oral route or s.c. immunization targeting the iliac LNs with a particulate SIVp27:Ty-VLP vaccine elicits SIVgag-specific CTL in the regional LNs as well as in the spleen and PBMC. Targeted LN immunization with this vaccine elicited MHC class I-restricted CD8+ CTL respons
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24

Shen, Xuzhuang, Teresa Lagergård, Yonghong Yang, Marianne Lindblad, Margareta Fredriksson, and Jan Holmgren. "Systemic and Mucosal Immune Responses in Mice after Mucosal Immunization with Group B Streptococcus Type III Capsular Polysaccharide-Cholera Toxin B Subunit Conjugate Vaccine." Infection and Immunity 68, no. 10 (2000): 5749–55. http://dx.doi.org/10.1128/iai.68.10.5749-5755.2000.

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ABSTRACT Group B streptococci (GBS) colonize the female genital and rectal tracts and can cause invasive infection in susceptible newborns. An optimally effective GBS vaccine should induce mucosal and systemic immunity. In this study, we investigate the local and systemic immune responses to GBS type III capsular polysaccharide (CPS) after mucosal vaccination of mice via intranasal, peroral, rectal, and vaginal routes, with GBS type III CPS conjugated with recombinant cholera toxin B subunit (GBS III CPS-rCTB). Cholera toxin (CT) was added as an adjuvant. Immunoglobulin G (IgG) and IgA antibod
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25

Hillier, Sharon L., Patricia Ferrieri, Morven S. Edwards, et al. "A Phase 2, Randomized, Control Trial of Group B Streptococcus (GBS) Type III Capsular Polysaccharide-tetanus Toxoid (GBS III-TT) Vaccine to Prevent Vaginal Colonization With GBS III." Clinical Infectious Diseases 68, no. 12 (2018): 2079–86. http://dx.doi.org/10.1093/cid/ciy838.

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Abstract Background Group B Streptococcus (GBS) frequently colonizes pregnant women and can cause sepsis and meningitis in young infants. If colonization was prevented through maternal immunization, a reduction in perinatal GBS disease might be possible. A GBS type III capsular polysaccharide (CPS)-tetanus toxoid conjugate (III-TT) vaccine was evaluated for safety and efficacy in preventing acquisition of GBS colonization. Methods Healthy, nonpregnant women aged 18–40 years and screened to be GBS III vaginal and rectal culture negative were randomized to receive III-TT conjugate or tetanus dip
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26

Li, Guocai, Hongmei Jiao, Guihua Jiang, et al. "Neisseria gonorrhoeae NspA Induces Specific Bactericidal and Opsonic Antibodies in Mice." Clinical and Vaccine Immunology 18, no. 11 (2011): 1817–22. http://dx.doi.org/10.1128/cvi.05245-11.

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ABSTRACTNeisseria gonorrhoeaesurface protein A (NspA) is a highly conserved gonococcal antigen. To explore the potential of NspA in vaccine development against gonorrhea, BALB/c mice were immunized with pcNspA containing the NspA gene fromN. gonorrhoeaestrain WHO-A via intramuscular (i.m.) injection, intranasal (i.n.) immunization, or intravaginal (i.vag.) immunization. Following the last DNA immunization, mice were boosted with recombinant NspA (rNspA). Enzyme-linked immunosorbent assays (ELISAs) indicated that all immunized mice generated measurable NspA-specific IgG and IgA in serum and sec
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27

Vagvala, Sri P., Lydia G. Thebeau, Saydra R. Wilson, and Lynda A. Morrison. "Virus-Encoded B7-2 Costimulation Molecules Enhance the Protective Capacity of a Replication-Defective Herpes Simplex Virus Type 2 Vaccine in Immunocompetent Mice." Journal of Virology 83, no. 2 (2008): 953–60. http://dx.doi.org/10.1128/jvi.02022-08.

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ABSTRACT Herpes simplex virus 2 (HSV-2) and, to a lesser extent, HSV-1 cause the majority of sexually transmitted genital ulcerative disease. No effective prophylactic vaccine is currently available. Replication-defective HSV stimulates immune responses in animals but produces no progeny virus, making it potentially useful as a safe form of live vaccine against HSV. Because it does not replicate and spread in the host, however, replication-defective virus may have relatively limited capacity to solicit professional antigen presentation. We previously demonstrated that in mice devoid of B7-1 an
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De Bernardis, Flavia, Maria Boccanera, Daniela Adriani, Antonietta Girolamo, and Antonio Cassone. "Intravaginal and Intranasal Immunizations Are Equally Effective in Inducing Vaginal Antibodies and Conferring Protection against Vaginal Candidiasis." Infection and Immunity 70, no. 5 (2002): 2725–29. http://dx.doi.org/10.1128/iai.70.5.2725-2729.2002.

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ABSTRACT Oophorectomized, estrogen-treated rats were immunized by the intravaginal or intranasal route with a mannoprotein extract (MP) or secreted aspartyl proteinases (Sap) of Candida albicans, with or without cholera toxin as a mucosal adjuvant. Both routes of immunization were equally effective in (i) inducing anti-MP and anti-Sap vaginal antibodies and (ii) conferring a high degree of protection against the vaginal infection by the fungus. These data suggest that appropriate fungal antigens and adjuvant can be used to protect against candidal vaginitis, by either route.
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Garulli, Bruno, Yoshihiro Kawaoka, and Maria R. Castrucci. "Mucosal and Systemic Immune Responses to a Human Immunodeficiency Virus Type 1 Epitope Induced upon Vaginal Infection with a Recombinant Influenza A Virus." Journal of Virology 78, no. 2 (2004): 1020–25. http://dx.doi.org/10.1128/jvi.78.2.1020-1025.2004.

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ABSTRACT The humoral and cellular immune responses in the genital mucosa likely play an important role in the prevention of sexually transmitted infections, including infection with human immunodeficiency virus type 1 (HIV-1). Here we show that vaginal infection of progesterone-treated BALB/c mice with a recombinant influenza virus bearing the immunodominant P18IIIB cytotoxic T-lymphocyte (CTL) epitope of the gp160 envelope protein from an HIV-1 IIIB isolate (P18IIIB; RIQRGPGRAFVTIGK) can induce a specific immune response in regional mucosal lymph nodes, as well as in a systemic site (the sple
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Pettini, Elena, Gennaro Prota, Annalisa Ciabattini, et al. "Vaginal Immunization to Elicit Primary T-Cell Activation and Dissemination." PLoS ONE 8, no. 12 (2013): e80545. http://dx.doi.org/10.1371/journal.pone.0080545.

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31

VanCott, Thomas C., Robert W. Kaminski, John R. Mascola, et al. "HIV-1 Neutralizing Antibodies in the Genital and Respiratory Tracts of Mice Intranasally Immunized with Oligomeric gp160." Journal of Immunology 160, no. 4 (1998): 2000–2012. http://dx.doi.org/10.4049/jimmunol.160.4.2000.

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Abstract Because mucosal surfaces are a primary route of HIV-1 infection, we evaluated the mucosal immunogenicity of a candidate HIV-1 vaccine, oligomeric gp160 (o-gp160). In prior studies, parenteral immunization of rabbits with o-gp160 elicited broad neutralizing serum Ab responses against both T cell line-adapted HIV-1 and some primary HIV-1 isolates. In this study, nasal immunization of mice with o-gp160, formulated with liposomes containing monophosphoryl lipid A (MPL), MPL-AF, proteosomes, emulsomes, or proteosomes with emulsomes elicited strong gp160-specific IgG and IgA responses in se
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32

Leontieva, Galina F., Tatyana A. Kramskaya, Irina V. Koroleva, Evgenia V. Kuleshevich, Nadezhda V. Duplik, and Alexander N. Suvorov. "Hybrid multiepitope recombinant vaccine for protection against infection caused by group B streptococcus." Medical academic journal 24, no. 4 (2024): 60–73. https://doi.org/10.17816/maj635351.

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BACKGROUND: Streptococcus agalactiae, commonly known as group B streptococcus, is an important pathogen responsible for severe and sometimes fatal invasive infections in newborns. It also poses a significant risk to older adults and those with weakened immune systems. Current preventive strategies primarily include the use of antibiotics to prevent maternal-to-fetal transmission of group B streptococcus and to treat established infections. The emergence of antibiotic-resistant strains has reduced the effectiveness of these treatments and highlighted the need for alternative preventive measures
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Wassen, Lotta, and Marianne Jertborn. "Influence of Exogenous Reproductive Hormones on Specific Antibody Production in Genital Secretions after Vaginal Vaccination with Recombinant Cholera Toxin B Subunit in Humans." Clinical and Vaccine Immunology 13, no. 2 (2006): 202–7. http://dx.doi.org/10.1128/cvi.13.2.202-207.2006.

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ABSTRACT The objective of this study was to investigate the influence of exogenous reproductive hormones on the local and systemic production of specific immunoglobulin A (IgA) and IgG antibodies after vaginal vaccination with recombinant cholera toxin subunit B (CTB). Three groups of women using either progesterone-containing intrauterine devices (n = 9), oral contraceptives (n = 8), or no hormonal contraceptive methods (n = 9) were vaginally immunized twice, 2 weeks apart. Cervical secretions, vaginal fluids, and serum were collected before and after vaccination. Total and CTB-specific IgA a
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34

Kuklin, Nelly A., Massoud Daheshia, Sangjun Chun, and Barry T. Rouse. "Role of Mucosal Immunity in Herpes Simplex Virus Infection." Journal of Immunology 160, no. 12 (1998): 5998–6003. http://dx.doi.org/10.4049/jimmunol.160.12.5998.

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Abstract This study evaluates whether the vaginal mucosal surface of immunized mice can prevent invasion by herpes simplex virus (HSV) and aims to identify immune components that affect immunity after challenge at the vaginal mucosa. Despite the induction of both IgA and IgG vaginal Ab following immunization with recombinant vaccinia virus vectors expressing either glycoproteins B or D, viral infection occurred in most animals even after minimal viral dose challenge. Challenged immune animals, including those genetically unable to generate anti-HSV Ab, survived and showed few if any clinical s
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35

Li, Weidang, Ashlesh K. Murthy, M. Neal Guentzel, et al. "Immunization with a Combination of Integral Chlamydial Antigens and a Defined Secreted Protein Induces Robust Immunity against Genital Chlamydial Challenge." Infection and Immunity 78, no. 9 (2010): 3942–49. http://dx.doi.org/10.1128/iai.00346-10.

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ABSTRACT We have previously demonstrated the efficacy of recombinant chlamydial protease-like activity factor (rCPAF; a secreted chlamydial protein) in inducing antigen-specific CD4+ T cell/gamma interferon (IFN-γ)-mediated but not antibody-mediated chlamydial clearance and reduction of upper genital tract (UGT) pathological sequelae. Since chlamydial integral antigens may induce neutralizing antibody protection, we further evaluated induction of protective immunity using a combination of rCPAF and UV-inactivated chlamydial elementary bodies (UV-EB) against vaginal chlamydial challenge in comp
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Gupta, Soumi, Ramesh Janani, Qian Bin, et al. "Characterization of Human Immunodeficiency Virus Gag-Specific Gamma Interferon-Expressing Cells following Protective Mucosal Immunization with Alphavirus Replicon Particles." Journal of Virology 79, no. 11 (2005): 7135–45. http://dx.doi.org/10.1128/jvi.79.11.7135-7145.2005.

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ABSTRACT A safe, replication-defective viral vector that can induce mucosal and systemic immune responses and confer protection against many infectious pathogens, such as human immunodeficiency virus type 1 (HIV-1), may be an ideal vaccine platform. Accordingly, we have generated and tested alphavirus replicon particles encoding HIV-1 Gag from Sindbis virus (SIN-Gag) and Venezuelan equine encephalitis virus (VEE-Gag), as well as chimeras between the two (VEE/SIN-Gag). Following intramuscular (i.m.), intranasal (i.n.), or intravaginal (IVAG) immunization with VEE/SIN-Gag and an IVAG challenge w
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37

Uehling, David T., Walter J. Hopkins, and Edward Balish. "Decreased Immunologic Responsiveness Following Intensified Vaginal Immunization Against Urinary Tract Infection." Journal of Urology 143, no. 1 (1990): 143–45. http://dx.doi.org/10.1016/s0022-5347(17)39898-1.

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38

Uehling, David T., Lori J. James, Walter J. Hopkins, and Edward Balish. "Immunization Against Urinary Tract Infection with a Multi-Valent Vaginal Vaccine." Journal of Urology 146, no. 1 (1991): 223–26. http://dx.doi.org/10.1016/s0022-5347(17)37756-x.

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39

Mulero-Marchese, R. D., K. J. Blank, and T. G. Sieck. "Genetic Basis for Protection against Experimental Vaginal Candidiasis by Peripheral Immunization." Journal of Infectious Diseases 178, no. 1 (1998): 227–34. http://dx.doi.org/10.1086/515602.

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40

Tengvall, Sara, Annika Lundqvist, Roselyn J. Eisenberg, Gary H. Cohen, and Ali M. Harandi. "Mucosal Administration of CpG Oligodeoxynucleotide Elicits Strong CC and CXC Chemokine Responses in the Vagina and Serves as a Potent Th1-Tilting Adjuvant for Recombinant gD2 Protein Vaccination against Genital Herpes." Journal of Virology 80, no. 11 (2006): 5283–91. http://dx.doi.org/10.1128/jvi.02013-05.

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ABSTRACT Although sexually transmitted pathogens are capable of inducing pathogen-specific immune responses, vaginal administration of nonreplicating antigens elicits only weak, nondisseminating immune responses. The present study was undertaken to examine the potential of CpG-containing oligodeoxynucleotide (CpG ODN) for induction of chemokine responses in the genital tract mucosa and also as a vaginal adjuvant in combination with glycoprotein D of herpes simplex virus type 2 (HSV-2) for induction of antigen-specific immune responses. We found that a single intravaginal administration of CpG
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41

Childers, Noel K., Keri L. Miller, Giang Tong, et al. "Adjuvant Activity of Monophosphoryl Lipid A for Nasal and Oral Immunization with Soluble or Liposome-Associated Antigen." Infection and Immunity 68, no. 10 (2000): 5509–16. http://dx.doi.org/10.1128/iai.68.10.5509-5516.2000.

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ABSTRACT The effectiveness of monophosphoryl lipid A (MPL) as a mucosal adjuvant was investigated following oral or intranasal (i.n.) administration of an aqueous adjuvant formulation of MPL (MPL-AF) added to soluble antigen or liposomal antigen or incorporated into liposomal antigen membranes. Groups of BALB/c female mice were immunized with 50 to 100 μg of free or liposomal Streptococcus mutans crude glucosyltransferase (C-GTF) with or without MPL-AF added to the vaccine or incorporated into the liposomal membrane. Plasma, saliva, vaginal wash, and fecal extract samples were collected biweek
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42

Fitriadi, Yogi. "Case Report: Managing Dengue Fever at Home." Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) 4, no. 1 (2021): 23. http://dx.doi.org/10.22146/rpcpe.56865.

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The patient is 6 years old male child, the patient went to the clinic with his parents, complaints of fever since three days ago. The fever goes up and down, reduce with administration of fever medication. The patient complained of nose bleeds 2 times, accompanied by headache. headache feels throbbing, felt constantly, and decreases with rest. The Complaints are not accompanied by coughs, sneeze, dyspnea, epigastric pain, nausea, vomiting, black stool and bloody urine. Patients still want to eat and drink. The patient has no history of traveling out of town in the past 2 weeks.The patient's mo
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43

Lehner, T., L. A. Bergmeier, L. Tao, et al. "Targeted lymph node immunization with simian immunodeficiency virus p27 antigen to elicit genital, rectal, and urinary immune responses in nonhuman primates." Journal of Immunology 153, no. 4 (1994): 1858–68. http://dx.doi.org/10.4049/jimmunol.153.4.1858.

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Abstract A s.c. route of immunization was developed in non-human primates, which targets the genitourinary-rectal associated lymphoid tissue. A vaccine consisting of rSIV gag p27, expressed as hybrid Ty virus-like particles (p27: Ty-VLP) was administered in the proximity of the internal iliac lymph nodes. Secretory IgA and IgG Abs to the p27 Ag were elicited in the vaginal, male urethral, rectal and seminal fluids, urine and serum. Two or more immunodominant B cell epitopes were identified within peptides 51-90 and 121-170 of the sequence of p27, using serum or biliary IgA and IgG Abs. CD4+ T
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44

Newell, Marie-Louise, and Catherine Peckham. "Mother-to-child transmission of hepatitis B infection." Fetal and Maternal Medicine Review 10, no. 2 (1998): 109–19. http://dx.doi.org/10.1017/s0965539597000247.

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Most transmission of hepatitis B virus (HBV) infection occurs around the time of delivery through contact with contaminated vaginal secretions or blood. Hence, interventions to reduce vertical transmission of HBV depend on identification of the infected woman during pregnancy so that the newborn infant exposed to infection can be given immunoglobulin immediately after birth, and a course of immunization can be started.
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45

Bivas-Benita, Maytal, Liat Bar, Geoffrey O. Gillard, et al. "Efficient Generation of Mucosal and Systemic Antigen-Specific CD8+ T-Cell Responses following Pulmonary DNA Immunization." Journal of Virology 84, no. 11 (2010): 5764–74. http://dx.doi.org/10.1128/jvi.02202-09.

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ABSTRACT Although mucosal CD8+ T-cell responses are important in combating mucosal infections, the generation of such immune responses by vaccination remains problematic. In the present study, we evaluated the ability of plasmid DNA to induce local and systemic antigen-specific CD8+ T-cell responses after pulmonary administration. We show that the pulmonary delivery of plasmid DNA formulated with polyethyleneimine (PEI-DNA) induced robust systemic CD8+ T-cell responses that were comparable in magnitude to those generated by intramuscular (i.m.) immunization. Most importantly, we observed that
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46

Uehling, David T., Walter J. Hopkins, Edward Balish, Yina Xing, and Dennis M. Heisey. "Vaginal Mucosal Immunization for Recurrent Urinary Tract Infection: Phase II Clinical Trial." Journal of Urology 157, no. 6 (1997): 2049–52. http://dx.doi.org/10.1016/s0022-5347(01)64671-8.

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47

Mulero-Marchese, Rocio D., Kenneth J. Blank, and T. G. Sieck. "Strain-dependent migration of lymphocytes to the vaginal mucosa after peripheral immunization." Immunogenetics 49, no. 11-12 (1999): 973–80. http://dx.doi.org/10.1007/s002510050581.

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48

Wei, S., W. Zou, T. Zhang, Y. Zhang, Z. Gong, and Y. Li. "Effects of GnRH agonist immunization on vaginal electrical resistance, FSH, LH, and ovaries in prepubertal female sheep." Czech Journal of Animal Science 58, No. 9 (2013): 420–28. http://dx.doi.org/10.17221/6942-cjas.

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The study is aimed at the investigation of the effects of GnRH agonist (alarelin) immunization on the vaginal electrical resistance (VER) and secretion of FSH and LH in sheep. Forty-two prepubertal female sheep were assigned to six groups (n = 7). Animals in experimental groups I (EG-I), II (EG-II), and III (EG-III) were twice subcutaneously injected with 200, 300, and 400 µg of alarelin antigens, respectively. Animals in experimental groups IV (EG-IV) and V (EG-V) were four times subcutaneously injected with 200 and 300 µg of alarelin antigens, respectively. Animals in the
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49

Alpert, Michael D., Andrew R. Rahmberg, William Neidermyer, et al. "Envelope-Modified Single-Cycle Simian Immunodeficiency Virus Selectively Enhances Antibody Responses and Partially Protects against Repeated, Low-Dose Vaginal Challenge." Journal of Virology 84, no. 20 (2010): 10748–64. http://dx.doi.org/10.1128/jvi.00945-10.

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ABSTRACT Immunization of rhesus macaques with strains of simian immunodeficiency virus (SIV) that are limited to a single cycle of infection elicits T-cell responses to multiple viral gene products and antibodies capable of neutralizing lab-adapted SIV, but not neutralization-resistant primary isolates of SIV. In an effort to improve upon the antibody responses, we immunized rhesus macaques with three strains of single-cycle SIV (scSIV) that express envelope glycoproteins modified to lack structural features thought to interfere with the development of neutralizing antibodies. These envelope-m
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50

Wu, Hong-Yin, Samira Abdu, Dana Stinson, and Michael W. Russell. "Generation of Female Genital Tract Antibody Responses by Local or Central (Common) Mucosal Immunization." Infection and Immunity 68, no. 10 (2000): 5539–45. http://dx.doi.org/10.1128/iai.68.10.5539-5545.2000.

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ABSTRACT Genital antibody responses were compared in female mice immunized intravaginally (i.vag.) or intranasally (i.n.) with a bacterial protein antigen (AgI/II of Streptococcus mutans) coupled to the B subunit of cholera toxin. Serum and salivary antibodies were also evaluated as measures of disseminated mucosal and systemic responses. Although i.vag. immunization induced local vaginal immunoglobulin A (IgA) and IgG antibody responses, these were not disseminated to a remote secretion, the saliva, and only modest levels of serum antibodies were generated. In contrast, i.n. immunization was
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