Academic literature on the topic 'Vaginal Smear'
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Journal articles on the topic "Vaginal Smear"
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Sheela, Wills G., P. Vijayalakshmi, Mohanambal, and Deepa Dharishini. "Detection of protozoal Trichomonas vaginalis and abnormal vaginal flora in high vaginal smear." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 2 (January 31, 2017): 563. http://dx.doi.org/10.18203/2320-1770.ijrcog20170382.
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Background: Vagina is the fibro muscular membrane sheath communicating with the uterine cavity and to the exterior at the vulva. Infection of female genital tract results from vaginal flora, extraneous agents and sexually transmitted diseases. The objective of the study was: a) high vaginal smear screening to find out incidence of abnormal vaginal flora of micro-organisms, b) prevalence of protozoal Trichomonas vaginalis.Methods: Rural women from in and around Ammapettai in the age group of 20-50 years attending Gynaecology OPD of SSSMC&RI for vaginal discharge and itching vulva. Exclusion criteria were age less than 20 and above 50 and pruritis vulva due to other causes the study size comprised of 50 women. After getting Institutional ethical committee’s approval and written informed consent from the patients, detailed history regarding type of discharge, odour, itching, and associated bleeding was taken. Per speculum and per vaginal examination done. High vaginal smear for aerobic bacterial profile and Trichomonas infection were taken and transported to microbiology laboratory for staining and culture. Wet mount microscopic examination of Trichomonas vaginalis and Candidiasis with saline and KOH mount done.Results: Out of 100 smears 9 were normal vaginal flora organisms, aerobic pathogens 43%, Trichomonas vaginalis (TV) 30%, and Candida albicans 5% mixed infections on 7 smears. E. coli was seen in 23 samples, Klebsiella in 14, Pseudomonas aeroginosa 4, Staphylococcus in 6 samples. Gram negative organisms were 100% sensitive to imipenem, amikacin and gentamycin and 100% resistant to cefazolin, 80% to ceftazidime, 74% to cefotaxime. Gram positive staphylococcus 50% were resistant to gentamycin, ampicillin.Conclusions: This study reflects on our responsibility to create awareness among women regarding abnormal vaginal discharge through proper health education routine screening targeted treatment to envisage healthy quality life.
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J., Girishma, Rupakala B. M., and Sunil Chavan. "Comparative study of pap smear and microbiological pattern in bacterial vaginosis." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 3 (February 27, 2018): 1039. http://dx.doi.org/10.18203/2320-1770.ijrcog20180888.
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Background: Bacterial vaginosis is the most common cause of vaginal discharge among women in reproductive age group. It is characterized by an increased vaginal pH and loss of normal lactobacilli and overgrowth of anaerobes like Gardnerella vaginalis and other gram-negative rods. Purpose of this study is to compare the characteristics of pap smear and microbiological pattern in patients with abnormal vaginal discharge.Methods: The study was conducted in the Department of Gynecology and Obstetrics of Rajarajeswari Medical College and Hospital (RRMCH) Bangalore, India. All patients with vaginal discharge were included in the study. Vaginal discharge samples were sent to gram staining, culture and pap smear examination.Results: Of the 52 patients, 18 patients (34.6%) showed positive for bacterial vaginosis according to Nugent’s score. Of the 18 patients with positive Gram stains, 8 of them were positive for bacterial vaginosis according to pap’s smear (44%) and 10 had negative pap smears. In our study, of the 18 patients with positive Gram stains, 14 (77%) of them were positive for bacterial vaginosis according to culture.Conclusions: In the present study we found out that correlation of gram stain and pap smear was 44% whereas correlation of gram stain and culture was 77%. Hence, we conclude that gram stain and culture are preferred for the diagnosis of bacterial vaginosis rather than the pap smear evaluation.
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Hajdu, Steven I. "The first vaginal smear." Journal of the American Society of Cytopathology 3, no. 5 (September 2014): 225–26. http://dx.doi.org/10.1016/j.jasc.2014.05.002.
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Eason, Erica, Baldwin Toye, George A. Wells, and Mary Senterman. "Assessment of Two Alternative Sample Transport and Fixation Methods in the Microbiological Diagnosis of Bacterial Vaginosis." Canadian Journal of Infectious Diseases 14, no. 6 (2003): 322–26. http://dx.doi.org/10.1155/2003/312429.
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BACKGROUND: The standard method for specimen collection and transport for microbiological diagnosis of bacterial vaginosis is an air-dried smear of vaginal secretions, promptly heat- or alcohol-fixed, Gram-stained and scored by Nugent's criteria.OBJECTIVE: Two alternative methods are evaluated: sending a swab in transport medium to be smeared and Gram-stained in the laboratory two days later; and sending a smear of vaginal secretions sprayed with cytological fixative to the laboratory for Gram staining seven days later.PATIENTS AND METHODS: One hundred fifty-two women aged 18 years and older who attended a hospital colposcopy clinic or a community healthy sexuality clinic were studied. This was a prospective study: three vaginal swabs were taken from each patient and handled as described above. Each slide was blindly and independently interpreted by two microbiology technologists. The sensitivity, specificity and coefficient of agreement of the transported swab and cytologically fixed methods were compared with the air-dried smear method.RESULTS: Smears from swabs in transport medium and cytologically fixed smears both had 90% sensitivity and 97% specificity for bacterial vaginosis compared with diagnosis from air-dried smears. Cohen's kappa was 0.88 (95% CI 0.79 to 0.97) for each method. Inter-rater reliability assessed over all slides (all sampling techniques) was excellent (kappa 0.94).CONCLUSIONS: For the diagnosis of bacterial vaginosis, both alternative techniques provide results equivalent to air-dried direct smears. A vaginal smear sprayed with cytological fixative provides immediate fixation of material to the slide, permits delays in swab transport and avoids the requirement for transport at a controlled temperature imposed by swabs.
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Гришина, Darya Grishina, Минюк, and Lyudmila Minyuk. "CYTOMORPHOLOGY VAGINAL SMEARS OF DOGS IN DIFFERENT PERIODS OF THE SEXUAL CYCLE." Bulletin Samara State Agricultural Academy 1, no. 4 (October 27, 2016): 86–89. http://dx.doi.org/10.12737/21717.
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The purpose of work is improving the efficiency of fertilization dog breed French Bulldog. The results of cytological examination of vaginal mucus in dogs at different periods of the sexual cycle. This will determine the optimal time for insemination. As a result of vaginal smear cytology of dogs among the signs of days favorable for breeding are the days when cytological smears appear more than 60% of the surface of pycnotic cells, a small amount of red blood cells and white blood cells, superficial cells are arranged in groups of 4-6 cells or clusters in the form of tiles. Proestrus phase corresponds to the presence of only of basal cells in a smear at the beginning. Then trend towards a decrease of intermediate and superficial cell growth. In the smears are found red blood cells and white blood cells. The duration of the stage of 6-8 days. Estrus phase is characterized by the appearance in the smear of more than 60% of the surface of pycnotic cells, a minor amount of red blood cells and white blood cells. The duration of the stage of 10-11 days. It was found that in dogs the most optimal days for mating are 3-4 day estrus. A smear diestrus phase accompanied by the presence of abrupt changes in the cellular structure. The picture a smear vaginal mucus in diestrus are signs are reducing the number of superficial cells, and increasing the number of intermediate cells; changes in the nature and appearance leukocyte, smear of mucus becomes turbid, dusky background. The duration of stage about 60 days. In anestrus cytological picture of the mucous membrane is stable. There are small cell in smears, revealed basal epithelial cells, can occur intermediate unit cells and leukocytes. The duration of the stage about 123 days.
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Pathak, Rakesh, P. Pradhan, S. Pudasaini, S. Maharjan, and AS Basnyat. "Study of Trichomonas Vaginalis and Bacterial Vaginosis in Pap smear at a Tertiary Health Care Centre of Nepal." Nepal Medical College Journal 22, no. 1-2 (July 9, 2020): 8–12. http://dx.doi.org/10.3126/nmcj.v22i1-2.29926.
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Cervical-vaginal infections are common problems in women of reproductive age presented with clinical features like white vaginal discharge, foul smelling odor and pruritis. Trichomonas vaginalis, Candidia and Gardnerella vaginalis are responsible for infectious vaginitis in creating anaerobic environment favoring Bacterial vaginosis caused by organisms like Gardnerella vaginalis, Chlamydia Trachomatis. Papanicolaou (Pap) smear examination is the simple, quick, painless routine screening test used for identification and detection of precancerous changes of uterine cervix as well as the cervico-vaginal infections resulting from bacterial, fungal and candida infections. The prime objective of the study was to identify the age wise distribution of cervical-vaginal infections and determine the frequency of Trichomonas vaginalis (TV) and Bacterial vaginosis (BV). A descriptive cross-sectional study was carried out in the Department of Pathology, Nepal Medical College and Teaching Hospital, Kathmandu. A total of 163 cases of TV and BV diagnosed on Pap smear were taken for the study. However, 564 Pap smears were received in the Department of Pathology for cytological evaluation during the study period. Once the smears were stained, the presence of clue cells, cannon balls and Trichomonas were observed. Out of 564 Pap smears received during the study period, 163 cases were of BV, TV and combined BV and TV. These 163 cases were included in our study. The age ranged from 20 to 65 years with majority (19.1%) of the women belonging to 35-39 years and the mean age was 38.18 ± 10.18 years. There were 97 cases (17.2%) of BV, 50 cases (8.9%) of TV and 16 cases (2.8%) of TV and BV co-infection. Bacterial vaginosis was the most predominant type of cervicovaginal infection followed by TV infection and TV and BV co-infections. Trichomonas vaginalis may create an environment favoring the development of BV. Pap screening could be the beneficial tool in early disease diagnosis and helps in preventing further complications by starting appropriate treatment.
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KARAGIANNIDIS (Α. ΚΑΡΑΓΙΑΝΝΙΔΗΣ), A., Th TSILIGIANNI (Θ. ΤΣΙΛΙΓΙΑΝΝΗ), and I. AMARANTIDIS (Ι. ΑΜΑΡΑΝΤΙΔΗΣ). "The cytological examination of vaginal smears in dogs." Journal of the Hellenic Veterinary Medical Society 50, no. 3 (January 31, 2018): 223. http://dx.doi.org/10.12681/jhvms.15719.
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The cytological examination of vaginal smears is a simple, quick and inexpensive method for determination of the estrous cycle stage in dogs. Also, the procedure of vaginal smear collection is painless for the animal. Smears are examined under light microscope, after they have been stained by a proper staining method. The results are based on the observation of cytological alterations of the epithelium cells under the influence of ovarian hormones.
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Zivaljevic, Biljana, Ilija Golubovic, Jelena Seratlic, Petar Nikolic, Dusan Simic, Ivica Magdic, Snezana Maric-Krejovic, Danijela Markovic-Knezevic, and Snezana Krsmanovic. "Efficiency of fenticonazole for the treatment of vaginal candidiasis." Srpski arhiv za celokupno lekarstvo 140, no. 7-8 (2012): 469–74. http://dx.doi.org/10.2298/sarh1208469z.
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Introduction. Uncomplicated vulvovaginal candidiasis appears in 75% women of reproductive age. The most frequent causes are Candida albicans (85-95%) or C. glabrata, and infrequently C. krusei, C. tropicalis, C. parapsilosis, C. pseudotropicalis, etc. Objective. The aim of the study was to investigate efficiency and safety of fenticonazole for vaginal candidiasis treatment. Methods. Therapeutic effect of a single 600 mg fenticonasole vaginal capsule was observed in 417 women, aged 16-67, in five centers in Serbia. In all women, before the treatment, vaginal candidiasis was confirmed by testing of vaginal smear. Based on smear findings and associated symptoms observed on the 7th and 28th day after therapy administration, treatment results were evaluated. On the next day after drug application the patients recorded by using a questionnaire their own feelings on withdrawal symptoms and possible side effects in the period prior to the first control. Results. Control after seven days showed a statistically significant decrease of symptoms. In 385 women, vaginal smear was found negative to yeast and yeast blastospores. Within the first seven days after treatment 84 women had to repeat therapy due to the persistence of symptoms or positive vaginal smear. After 28 days we recorded full recovery in 392 patients, clinical improvement in eight, no change in 16, and deterioration in one patient only. Side effects were very seldom, mostly in the form of a slight redness of the vulva and vagina, and mild itching during several days. Conclusion. Our observations confirmed good efficacy and safety of fenticonazole in the treatment of vaginal candidiasis.
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Behbakht, Kian, Jennifer Friedman, Ira Heimler, Alla Aroutcheva, Jose Simoes, and Sebastian Faro. "Role of the Vaginal Microbiological Ecosystem and Cytokine Profile in the Promotion of Cervical Dysplasia: A Case–Control Study." Infectious Diseases in Obstetrics and Gynecology 10, no. 4 (2002): 181–86. http://dx.doi.org/10.1155/s1064744902000200.
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Objective:To identify alterations in the cytokine profile and microbial ecosystem of the vagina in association with cervical dysplasia.Methods:Demographics, lifestyle variables and Papanicolau (Pap) smear results of subjects presenting to the same site for gynecologic complaints, obstetric visits or colposcopy were prospectively recorded. Vaginal smear for Gram stain, aerobic and anaerobic culture, pH, and wet mount and KOH examination forTrichomonas vaginalis,Gardnerella vaginalisand yeast organisms were performed. Vaginal lavage specimens were centrifuged, and the pellets and supernatants were assayed for human papillomavirus (HPV) by polymerase chain reaction and for cytokines interleukin (IL)-1ß IL-6, IL-10 and IL-12 by enzyme-linked immunosorbent assay (ELISA) respectively. Subjects with abnormal Pap smears underwent colposcopy and biopsy as indicated.Results: Of 51 patients, 32 were referred for colposcopy, 12 presented with gynecologic needs, and seven presented for obstetric visits. Median age was 24 years. Demographics did not differ significantly between the dysplasia and control groups except for a trend towards more sexual partners in the dysplasia group. Biopsies were performed in 81% (26/32) of patients presenting for colposcopy and 17 revealed cervical intraepithelial neoplasia. IL-1ß, IL-6, IL-10, and IL-12 levels were elevated in 63% (20/32), 38% (15/39), 4% (2/49), and 0% of samples respectively. Elevated vaginal lavage IL-1ß was associated with a 6.1 odds ratio (95% confidence interval 1.06–35) of cervical dysplasia. Alterations in other variables studied were not associated with cervical dysplasia.Conclusions: Elevated IL-1ß, possibly representing a complex host inflammatory response to multiple pathogens, was demonstrated in patients with cervical dysplasia.
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Nadeak, Kristina. "Diagnostic test of urine sample, vaginal smear and combination of urine with vaginal smear to identify Neisseria gonorrhoeae with polymerase chain reaction method." International Journal of Research in Medical Sciences 7, no. 7 (June 28, 2019): 2547. http://dx.doi.org/10.18203/2320-6012.ijrms20192625.
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Background: Gonorrhoea is a disease caused by Neisseria gonorrhoeae that is transmitted through sexual contact. There are several examinations performed on gonorrhoea infection, one of them is Polymerase Chain Reaction (PCR). The objective is to determine the diagnostic test of urine samples, vaginal smear and combination of urine and vaginal smear in identifying Neisseria gonorrhoeae using the PCR method.Methods: This study is a diagnostic test with a cross-sectional design involving 58 female sex workers (FSW). All FSWs are carried out of history and physical examination. Urine sampling, vaginal smear, combination of urine and vaginal smear, and endocervical smear were obtained for identifying Neisseria gonorrhoeae using PCR method, then a diagnostic test analysis of each sample was performed.Results: The diagnostic test of PCR for Neisseria gonorrhoeae from urine samples was found sensitivity 44.4%, specificity 20.0%, positive predictive value (PPV) 83.3%, negative predictive value (NPV) 3.8% and accuracy 42.0%. From vaginal smear, we obtained sensitivity 34.0%, specificity 66.7%, PPV 88.2%, NPV 12.1% and accuracy 38.0%. And from combination of urine and vaginal smear, we obtained sensitivity 51.1%, specificity 20.0%, PPV 85.2%, NPV 4.3% and accuracy 48.0%.Conclusions: From these results the researchers suggested that urine, vaginal and combination of urine and vaginal smear could not be used as an alternative to examine the sensitivity and specificity of Neisseria gonorrhoeae, so the endocervical sample remained the reference sample for examination of nucleic acid amplification tests for Neisseria gonorrhoeae.
Dissertations / Theses on the topic "Vaginal Smear"
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Mandelson, Margaret T. "Cervical cancer : associations with HPV infection, barrier contraceptive use, and Pap smear screening /." Thesis, Connect to this title online; UW restricted, 1994. http://hdl.handle.net/1773/10919.
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Eaker, Sonja. "Optimization of compliance in epidemiologic research and disease prevention : with special emphasis on PAP-smear screening /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-454-2/.
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Vasconcelos, Camila Teixeira Moreira. "IntervenÃÃo comportamental e educativa: efeitos na adesÃo das mulheres à consulta de retorno para receber o resultado do exame colpocitolÃgico." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7701.
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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel SuperiorEsta pesquisa relata os efeitos das intervenÃÃes comportamental e educativa na adesÃo das mulheres à consulta de retorno para receber o resultado do exame colpocitolÃgico. Para tanto, foi realizado um estudo experimental do tipo randomizado controlado com comparaÃÃo entre trÃs grupos: intervenÃÃo educativa (sessÃo educativa e demonstraÃÃo do exame), intervenÃÃo comportamental (fita lembranÃa) e um grupo que recebe a intervenÃÃo-padrÃo (cartÃo contendo a data da consulta de retorno â lembrete grÃfico), aqui denominado de grupo de comparaÃÃo. A pesquisa foi realizada em um Centro de SaÃde da FamÃlia (CESAF), situado no bairro Vicente Pinzon, pertencente à Secretaria Executiva Regional II. A populaÃÃo do estudo foi composta pelas mulheres que realizaram o exame de prevenÃÃo do CCU no referido CESAF. A seleÃÃo da amostra obedeceu aos seguintes critÃrios de inclusÃo: ter iniciado atividade sexual e realizar o exame de prevenÃÃo do CCU no perÃodo de coleta de dados, perfazendo um total de 775 mulheres. O instrumento de coleta de dados utilizado para avaliar o conhecimento, a atitude e prÃtica das mulheres em relaÃÃo ao exame foi o inquÃrito CAP, submetido à validaÃÃo de face e conteÃdo. O perÃodo total da coleta de dados aconteceu em aproximadamente nove meses. Os dados foram analisados atravÃs do programa estatÃstico Statistical Package for the Social Sciences (SPSS), versÃo 18.0. Os dados evidenciaram que apesar de aproximadamente todas as mulheres (98,5%) terem ouvido falar sobre o exame colpocitolÃgico, a avaliaÃÃo do conhecimento foi classificada como inadequada para a maioria (72,3%). Aproximadamente a metade (58,6%) sabia sobre a finalidade do exame de prevenir o CCU. A atitude inadequada tambÃm alcanÃou altos percentuais (63,4%). O principal motivo apontado pelas mulheres para a realizaÃÃo do exame foi a presenÃa de queixas (38,3%). Por outro lado, a prÃtica do exame foi classificada para a maioria das mulheres (69,2%) como adequada, embora os dados quanto à periodicidade de realizaÃÃo do exame sugiram repetiÃÃo desnecessÃria, com alta concentraÃÃo do intervalo anual. Das 775 mulheres que compuseram a amostra, 585 (75,5%) retornaram para receber o resultado do exame com atà 65 dias. Quando comparadas as taxas de retorno entre os grupos, o grupo educativo apresentou o maior percentual de mulheres que retornou (GE = 82%/ GCT= 77%/ GCP= 66%), todavia essa diferenÃa sà foi estatisticamente significante quando comparada ao grupo comportamental (p=0,000). Por outro lado, quando comparadas as mÃdias de dias com que as mulheres retornaram para receber o resultado do exame, as mulheres do grupo educativo o fizeram com intervalo mÃdio de dias menor (Md=43 dias/ GE
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Lee, Yick-Kwong Chris. "A follow-up study of "atypical cells" in gynecologic cytology : the impact of the Bethesda System 2001 /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B34865652.
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Xavier, Júnior José Cândido Caldeira. "Risco estimado das lesões precursoras do colo do útero nos exames citológicos em função do tipo de lesão, intervalo entre os controles e da idade /." Botucatu, 2015. http://hdl.handle.net/11449/142980.
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Orientador: Rozany Mucha DuflothCoorientador: Luiz Carlos Zeferino
Banca: Cesar Cabello dos Santos
Banca: Sophie Françoise Mauricette Derchain
Banca: Gilberto Uemura
Banca: Maria Luiza Cotrim Sartor de Oliveira
Resumo: INTRODUÇAO: A utilização do exame de citologia cérvico-vaginal para rastreamento do carcinoma do colo do útero diminuiu a incidência e mortalidade desse carcinoma e não há dúvidas que a identificação de lesões precursoras é importante nos cuidados com a saúde da mulher. Há poucos estudos sobre a associação do resultado de citologia cérvico-vaginal alterado em mulheres gestantes e mulheres com sangramento genital brasileiras. Além disso, ainda permanece controverso se as gestantes deveriam ser submetidas ao exame de citologia cérvico-vaginal como rotina do pré-natal e se a citologia cérvico-vaignal pode ser utilizada como método único de exclusão de neoplasia do colo do útero para as mulheres com informação clínica de sangramento genital. OBJETIVOS: Estudar os fatores associados ao resultado do exame de citologia cérvico-vaginal alterado para mulheres gestantes e não-gestantes (idade, idade de início da atividade sexual, intervalo entre exames); e para mulheres com informação clínica de sangramento genital. MÉTODOS: Estudo observacional analítico que avaliou os resultados dos exames de citologia cérvico-vaginal encaminhados ao laboratório de Citopatologia Dr José Aristodemos Pinotti do Centro de Atenção Integrada à Saúde da Mulher da Universidade Estadual de Campinas durante o período de Janeiro de 2000 a Dezembro de 2009 (10 anos) oriundos de mais de 70 municípios da região de Campinas, São Paulo - Brasil. O resultado do exame de citologia cérvico-vaginal foi reportado de acordo com o Sistema Bethesda. A partir dos formulários próprios da Instituição foram extraídos dados clínicos, citopatológicos e sociodemográficos necessários para a realização do presente estudo. RESULTADOS: Controlada a idade, idade de início da atividade sexual e intervalo entre exames não há diferença quanto a prevalência de lesão intraepitelial escamosa de alto grau entre mulheres gestantes e...
Abstract: Not available
Doutor
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Xavier, Júnior José Cândido Caldeira [UNESP]. "Risco estimado das lesões precursoras do colo do útero nos exames citológicos em função do tipo de lesão, intervalo entre os controles e da idade." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/142980.
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000865266.pdf: 2803905 bytes, checksum: 8b210e35895c7a340ae000f9b3b39336 (MD5)INTRODUÇAO: A utilização do exame de citologia cérvico-vaginal para rastreamento do carcinoma do colo do útero diminuiu a incidência e mortalidade desse carcinoma e não há dúvidas que a identificação de lesões precursoras é importante nos cuidados com a saúde da mulher. Há poucos estudos sobre a associação do resultado de citologia cérvico-vaginal alterado em mulheres gestantes e mulheres com sangramento genital brasileiras. Além disso, ainda permanece controverso se as gestantes deveriam ser submetidas ao exame de citologia cérvico-vaginal como rotina do pré-natal e se a citologia cérvico-vaignal pode ser utilizada como método único de exclusão de neoplasia do colo do útero para as mulheres com informação clínica de sangramento genital. OBJETIVOS: Estudar os fatores associados ao resultado do exame de citologia cérvico-vaginal alterado para mulheres gestantes e não-gestantes (idade, idade de início da atividade sexual, intervalo entre exames); e para mulheres com informação clínica de sangramento genital. MÉTODOS: Estudo observacional analítico que avaliou os resultados dos exames de citologia cérvico-vaginal encaminhados ao laboratório de Citopatologia Dr José Aristodemos Pinotti do Centro de Atenção Integrada à Saúde da Mulher da Universidade Estadual de Campinas durante o período de Janeiro de 2000 a Dezembro de 2009 (10 anos) oriundos de mais de 70 municípios da região de Campinas, São Paulo - Brasil. O resultado do exame de citologia cérvico-vaginal foi reportado de acordo com o Sistema Bethesda. A partir dos formulários próprios da Instituição foram extraídos dados clínicos, citopatológicos e sociodemográficos necessários para a realização do presente estudo. RESULTADOS: Controlada a idade, idade de início da atividade sexual e intervalo entre exames não há diferença quanto a prevalência de lesão intraepitelial escamosa de alto grau entre mulheres gestantes e...
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Westin, Maria Cristina do Amaral 1949. "Celulas glandulares atipicas e adenocarcinoma "in situ" de acordo com a classificação de Bethesda 2001 : associação cito-histologica." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310570.
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Orientadores: Luiz Carlos Zeferino, Silvia Helena Rabelo dos SantosDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Introdução: Há evidências de que a incidência do adenocarcinoma do colo do útero tem aumentado, apesar dos programas de rastreamento. Foi a classificação do Sistema de Bethesda, em 1988, que incluiu o diagnóstico citológico relativo às células glandulares atípicas, que não estava presente nas classificações anteriores. Em sua revisão de 2001, o Sistema de Bethesda propôs a subclassificação do diagnóstico citológico de Anormalidades em Células Glandulares em: células glandulares atípicas sem outras especificações (AGC-SOE), células glandulares atípicas favorecendo neoplasia (AGC-FN) e adenocarcinoma in situ (AIS). Os diagnósticos citológicos de AGC constituem um problema clínico em consequência da falta de critérios citomorfológicos bem definidos para sua interpretação, do alto grau de variabilidade interobservador e da falta de achados colposcópicos característicos. O diagnóstico citológico de AIS, embora preditivo de neoplasia glandular, não pode diferenciar de modo preciso entre as formas in situ e invasiva, as quais só podem ser confirmadas pela histologia. Há, na literatura, divergentes opiniões quanto à utilidade desta subclassificação e sua análise é de grande relevância para prática clínica. Objetivo: Analisar a associação entre a classificação citológica do Sistema de Bethesda 2001 para as anormalidades do epitélio glandular cervical e o resultado histológico. Métodos: O estudo foi do tipo corte transversal analítico, prospectivo, realizado no Centro de Atenção Integral à Saúde da Mulher (CAISM), UNICAMP, entre 2002 e 2005, e incluiu uma série consecutiva de 155 mulheres com anormalidades glandulares endocervicais no exame citológico. Destas, 91 mulheres foram incluídas por AGC-SOE, 15 por AGC-FN; 14 por AIS e 35 por diagnóstico combinado de AGC associada à lesão escamosa intraepitelial de alto grau (HSIL). Os diagnósticos de AGC e AIS foram confirmados por dois observadores, de acordo com Sistema de Bethesda 2001. As mulheres com alterações glandulares,de origens outras que não endocervical, não foram incluídas no estudo. No primeiro atendimento foi colhido um segundo esfregaço cervical e realizada colposcopia em todas as mulheres. Foi realizada biópsia ou conização naquelas pacientes que tinham indicação, de acordo com a rotina assistencial do serviço. Todas as mulheres incluídas foram submetidas à ecografia pélvica. A magnitude da associação entre o diagnóstico citológico das anormalidades glandulares e o diagnóstico histológico foi estimada utilizando-se Odds ratio (OR), com respectivo intervalo de confiança (IC) de 95%. Resultados: Das 155 mulheres admitidas no estudo, 126 tiveram avaliação histológica. Tomando-se como referência AGC-SOE, os diagnósticos citológicos de AGC-FN e AIS foram significativamente associados com os resultados histológicos de neoplasia escamosa (NIC 2 ou pior diagnóstico) ou adenocarcinoma (in situ ou invasivo) com valores de odds ratio respectivamente de 10,50 (95% IC: 2,94- 37,55) e 156,00 (95% IC: 17,72-1373,46). Tomando-se como referência AGC-FN, o diagnóstico citológico de AIS foi significativamente associado com os resultados histológicos de neoplasia escamosa ou adenocarcinoma (OR=14,86; 95% IC: 1,53-144,23). Uma associação similar foi observada considerando-se os resultados histológicos de adenocarcinoma (in situ ou invasivo). Nenhuma associação foi observada para neoplasia escamosa analisada isoladamente. Os resultados histológicos de NIC 2 ou pior diagnóstico foram fortemente associados com AGC quando a lesão de alto grau (HSIL) também estava presente (OR=57,60; 95%IC: 18,25-181,76), mas nenhuma associação foi observada com resultado histológico de adenocarcinoma. Conclusões: Há uma associação significante entre as subclassificações da categoria de anormalidades em células glandulares de origem endocervical, propostas pelo Sistema de Bethesda 2001, e diagnósticos histológicos significativos, pois os diagnósticos citológicos de AGC-SOE, AGC-FN e AIS indicam um aumento progressivo de risco para adenocarcinoma. A presença de HSIL associada à AGC representa maior probabilidade de neoplasia escamosa, mas não de adenocarcinoma
Abstract: Introduction: There is evidence indicating that incidence of cervical adenocarcinoma has been increasing, despite the screening programs. The cytological diagnosis of atypical glandular cells, absent from previous versions, was included in the 1988 edition of the Bethesda System (TBS). In its review of 2001, the TBS has proposed the sub-classification of the cytological diagnosis of glandular cells abnormalities as: atypical glandular cells not otherwise specified (AGC-NOS), atypical glandular cells favor neoplastic (AGC-FN) and adenocarcinoma in situ "(AIS). The usefulness of the sub-classification of cytological diagnosis as atypical glandular cells not otherwise specified (AGC-NOS), atypical glandular cells favor neoplastic (AGC-FN) and adenocarcinoma in situ (AIS), as proposed in the 2001 TBS, is a controversial issue, but of great importance in clinical practice. AGC in cervical smears constitutes a clinical problem due to the lack of well-defined cytomorphological criteria for the interpretation of this finding, the high degree of interobserver variability and the lack of characteristic colposcopic features. Moreover, cytological AIS cannot specifically differentiate between AIS and invasive adenocarcinoma, which can only be confirmed by histology. Objective: to analyze the association between the 2001 TBS classification of glandular abnormalities and the histological outcome. Method: This cross-sectional and prospective study was conducted at the Center of Health Care of Women (CAISM), UNICAMP, between 2002 and 2005. The sample comprises a series of 155 women with glandular abnormalities in cervical smear. Of those, 91 women were included due to AGC-SOE, 15 due to AGC-FN, 14 due to AIS and 35 for AGC combined with high grade squamous intraepithelial lesions (HSIL). The diagnoses of AGC and AIS were confirmed by two observers according to the TBS 2001. Women with changes of glandular origin other than endocervical were excluded. In their first visit, a second cervical sample was collected from all women, and colposcopy was performed. A biopsy or a conization was performed when necessary, according to CAISM's protocols. All women underwent pelvic ultrassonography. Odds ratios (OR) with 95% confidence interval (95% CI) were used to evaluate the magnitude of the association between the cytological diagnosis of the glandular abnormalities and the significant histologic diagnosis. Results: Of the 155 women admitted to the study, 126 were submitted to histological examination. Taking as reference AGC-NOS, the cytological diagnosis of AGC-FN and AIS were significantly associated with the histological outcome of squamous neoplasia (CIN or worse) or adenocarcinoma (in situ or invasive) with OR values of 10.50 (95% CI: 2.94-37.55) and 156.00 (95% CI: 17.72-1373.46), respectively. Taking as reference AGC-FN, the cytological diagnosis of AIS was significantly associated with the histological outcome of squamous neoplasia or adenocarcinoma (OR=14.86; 95%CI: 1.53-144.23). Similar associations were observed for the histological outcome of adenocarcinoma, but no association was observed for only squamous neoplasia. Histological outcome of CIN2 or worse was strongly associated with AGC when HSIL was also present (OR = 57.60; 95% CI: 18.25- 181.76), but no association was observed with adenocarcinoma as the stand-alone histological outcome. Conclusions: There is an association between the subclassification of glandular cells abnormalities of endocervical origin proposed by 2001 TBS with significant histological outcomes. The cytological diagnoses of AGC-NOS, AGC-FN and AIS were progressively associated with adenocarcinoma. The histological outcome of squamous neoplasia is frequent but does not differ from these cytological interpretations. The presence of HSIL associated with AGC was associated with a greater probability of squamous neoplasia, but not
Mestrado
Ciencias Biomedicas
Mestre em Tocoginecologia
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Lee, Yick-Kwong Chris, and 李亦剛. "A follow-up study of "atypical cells" in gynecologic cytology: the impact of the Bethesda System 2001." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010286.
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Febrônio, Marília Vieira. "Citologia cérvico-vaginal inflamatória associada com atividade da doença no lúpus eritematoso sistêmico juvenil." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5145/tde-18042007-144902/.
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Objetivo: Avaliar a citologia cérvico-vaginal em adolescentes com lúpus eritematoso sistêmico juvenil (LESJ) e comparar com controles. Material e métodos: Cinqüenta e duas adolescentes com LESJ (critérios do American College of Rheumatology) foram comparadas com 52 controles saudáveis. Todos os esfregaços de Papanicolaou foram avaliados por uma mesma citopatologista, que desconhecia o exame ginecológico, e foram classificados de acordo com o Sistema de Bethesda, 2001. Resultados: As médias das idades das pacientes com LESJ e controles foram similares (16,17 ± 1,94 versus 16,13 ± 2,16 anos, p=0,92). A citologia cérvico-vaginal foi similar em ambos os grupos, embora as relações sexuais no último mês tenham sido menos freqüentes nas pacientes com LESJ em relação aos controles (23% versus 59,6%, p=0,0003). Apenas uma paciente (2%) com LESJ e duas controles (4%) tinham displasia cervical (LIE-BG) e papilomavírus humano (HPV) (p=1,0). Citologia cérvico-vaginal inflamatória foi observada em 21 (60%) das pacientes com SLEDAI maior ou igual a 4 e em apenas 4 (23%) daqueles com SLEDAI < 4 (p=0,001). Assim como, uma maior freqüência de achados inflamatórios também foi observada em adolescentes virgens com LESJ (57% versus 8%, p=0,005). Vaginite por Candida spp foi observada em 7 pacientes com LESJ (14%) e em nenhuma dos controles (p=0,012), e foi associada com uso de drogas imunossupressoras (p=0,01) e dose alta de prednisona (p=0,002). Conclusão: Nossos achados indicam que o trato genital feminino é um órgão alvo no LESJ, pois inflamação cérvico-vaginal está associada com atividade da doença independentemente da atividade sexual.Objective: To evaluate cervicovaginal cytology in adolescents with juvenile systemic lupus erythematosus (JSLE) and to compare them to controls. Material and methods: Fifty-two female adolescents with JSLE (American College of Rheumatology criteria) were compared to 52 age-matched healthy controls. All Pap smears were evaluated by the same cytopathologist blinded to gynecology examination, and performed according to the Bethesda Classification System 2001. Results: The mean age of JSLE patients and controls were similar (16.17 ± 1.94 vs. 16.13 ± 2.16 years, p=0.92). The cervicovaginal cytology was found to be similar in both groups, although sexual intercourses in the last month were less frequent in JSLE than controls (23% vs. 59.6%, p=0.0003). Only one patient (2%) with JSLE versus two controls (4%) had cervical dysplasia (LGSIL) and human papilomavirus (p=1.0). Inflammatory cervicovaginal cytology was observed in 21 (60%) of patients with SLEDAI ? 4 and only 4(23%) of those with SLEDAI<4 (p=0.001). Likewise, a higher frequency of inflammatory changes were also observed in virgin JSLE (57% vs. 8%, p=0.005). Candida spp vaginitis was observed in 7 JSLE (14%) versus none in controls (p=0.012) and was associated to immunosuppressive drugs (p=0.01) and high dose of prednisone (p=0.002). Conclusion: Our findings supports the notion that female genital tract is a target organ in SLE since cervical inflammation is associated to disease activity independently of sexual activity.
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Lundgren, Eva-Lisa. "Kunskap, förtrogenhet och upplevd vårdkvalitet - barnmorskors resonemang och kvinnors erfarenheter och upplevelser på den populationsbaserade cervixscreeningen i Stockholm /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-699-9/.
Full textBooks on the topic "Vaginal Smear"
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Boon, Mathilde E. The pap smear. 2nd ed. Leiden, Netherlands: Coulomb Press Leyden, 1993.
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H, Suurmeijer Albert J., ed. The Pap smear. 3rd ed. Australia: Harwood Academic Publishers, 1996.
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Dhurandhar, Nina. Papanicolaou technique: Approved guideline. 2nd ed. Wayne, Pa: NCCLS, 2001.
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Rushing, Lynda. Abnormal pap smears: What every woman needs to know. Amherst, N.Y: Prometheus Books, 2001.
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1957-, Joste Nancy, ed. Abnormal pap smears: What every woman needs to know. Amherst, N.Y: Prometheus Books, 2008.
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Rushing, Lynda. Abnormal pap smears: What every woman needs to know. Amherst, N.Y: Prometheus Books, 2001.
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Illinois. Office of Women's Health. Pap y examen pelvica: Las mujeres de Illinois pueden calificar para examenes gratuitos. Springfield, IL: Illinois Dept. of Public Health, Office of Women's Health, 2004.
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Stoll, Peter. Cytology in gynecological practice: An atlas of phase-contrast microscopy. 2nd ed. Berlin: Springer-Verlag, 1993.
Find full textBook chapters on the topic "Vaginal Smear"
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Lee, Christine U., and James F. Glockner. "Case 10.5." In Mayo Clinic Body MRI Case Review, edited by Christine U. Lee and James F. Glockner, 486–87. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199915705.003.0256.
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81-year-old woman with abnormal Papanicoulaou smear Sagittal FSE T2-weighted images (Figure 10.5.1) obtained after instillation of vaginal US gel demonstrate a large, mildly heterogeneous, well-defined lesion in the anterior proximal vagina. Sagittal arterial phase postgadolinium 3D SPGR images (Figure 10.5.2) reveal moderate diffuse enhancement of the lesion. Axial 3D SPGR image obtained 7 minutes after contrast injection (...
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"Vaginal examination and cervical smear and swab." In Get Through Clinical Finals: A Toolkit for OSCEs, 203–8. CRC Press, 2006. http://dx.doi.org/10.1201/b13262-37.
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"Trichomoniasis." In Oxford Handbook of Genitourinary Medicine, HIV, and Sexual Health, edited by Laura Mitchell, Bridie Howe, D. Ashley Price, Babiker Elawad, and K. Nathan Sankar, 225–32. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198783497.003.0016.
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In this chapter, infection with the flagellated protozoan Trichomonas vaginalis is reviewed. The epidemiology and aetiology of this parasitic infection of the human genitourinary tract is discussed and transmission, including potential routes of non-sexual transmission are detailed. Clinical presentation in women (commonly vaginal discharge, vulvo-vaginitis, strawberry cervix) and men (urethritis) are reviewed. The different diagnostic techniques (microscopy, culture, polymerase chain reaction, and point-of-care test) are compared and contrasted. Incidental diagnosis on a cervical smear is also discussed. The mainstay of management is oral metronidazole with appropriate partner notification. Alternatives for refractory cases are given, and the interplay of Trichomonas vaginalis and HIV is included.
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"Gynaecological problems." In Tasks for Part 3 MRCOG Clinical Assessment, edited by Sambit Mukhopadhyay and Medha Sule. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198757122.003.0019.
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This task assesses the following clinical skills: … ● Patient safety ● Communication with patients and their relatives ● Information gathering ● Applied clinical knowledge … You are in the gynaecology clinic and your next patient is Rachel Sawyer a 38- year- old woman suffering from heavy and irregular periods. She has a BMI of 42 and has been diagnosed with PCOS in the past. Your task is … ● To take a focussed history ● Explain what examination and investigations need to be performed to Rachel ● Make a management plan … You have 10 minutes for this task (+ 2mins initial reading time). Please read instructions to candidate and actor. Allow the candidate to conduct the interview undisturbed unless they are straying off the track of the question (in which case you can show them their instructions again). This patient has heavy and irregular periods. The history of presenting complaint should cover: … ● The extent, duration, and inconvenience caused by the bleeding ● Establish the menstrual history from menarche ● Last menstrual period and present menstrual cycle ● Past gynaecological history, including PCOS ● No medical, surgical, family history ● No allergies ● Normal and regular smears ● Nulliparous ● Wants to preserve fertility … Once the candidate has taken a relevant history, they are expected to explain that they will need to perform a speculum examination and bimanual examination to Rachel. They should explain that this is to rule out any obvious abnormality in the vagina/ cervix and to assess the uterus and adnexa. Abdominal examination— unremarkable: … ● Speculum examination— cervix satisfactory ● Bimanual examination— uterus bulky, retroverted, mobile, no adnexal masses Investigations ● Endometrial sampling— either at this consultation or accept another appointment- This is to assess the endometrium as, although 38, Rachel has risk factors of High BMI, PCOS, and nulliparity ● TVS- as Rachel has a high BMI, the sensitivity of an internal examination is reduced, TVS, not TAS will be useful due to high BMI.
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Dave, Jayshree, and C. Y. William Tong. "Urinary Tract and Genital Infections including Sexually Transmitted Infections (STIs)." In Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0042.
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Urethritis, characterized by inflammation of the urethra in men, is caused by Neisseria gonorrhoeae (gonococcus), Chlamydia trachomatis, Trichomonas vaginalis, and Mycoplasma genitalium. Other causes of non-gonococcal urethritis include ureaplasmas, adenoviruses, and herpes simplex viruses. The presence of urethritis is confirmed by the presence of five or more polymorphs in urethral smear by high-power microscopy. Symptoms can be minor to profound and vary from clear to mucopurulent discharge. Gonococcus is commoner in men who have sex with men (MSM) compared to heterosexuals, and high-risk activities such as chemsex parties increase spread with significant public health consequences. Antibiotic resistance in gonococcus has clinical and public health implications as three cases of extensively drug-resistant Neisseria gonorrhoeae with resistance to ceftriaxone (MIC = 0.5 mg/L) and high-level resistance to azithromycin (MIC > 256 mg/L) have been described compromising current treatment recommended by British Association for Sexual Health and HIV Guidelines (BASHH). In England an outbreak of high level azithromycin-resistant gonococcus has also been described by Public Health England (PHE), who alerted clinicians about the need for follow up and test of cure, contact tracing, and treatment failure. C. trachomatis infection can be treated with azithromycin 1g orally as a single dose or with seven days of oral doxycycline. Risk factors for chlamydia include age younger than twenty-five years, multiple sexual partners, and avoidance of barrier methods for contraception. Metronidazole 2g single dose or 400– 500mg twice daily for seven days is recommended for treatment of trichomonas, which can cause a moderate discharge in up to 60% of males. Resistance to azithromycin and doxycycline is common in M. genitalium strains and management of these patients with urethritis requires GUM referral for comprehensive investigation, contact tracing, and public health notification. Molecular methods are used for the diagnosis of these organisms and gonococcal culture is undertaken to obtain antimicrobial susceptibility data from patients with a previous diagnosis by molecular method, in GUM attendees, and their contacts. Herpes simplex infection results in a painful ulcer preceded by a vesicle. The diagnosis can be confirmed using polymerase chain reaction (PCR) tests of a swab taken from the vesicle or ulcer.
Conference papers on the topic "Vaginal Smear"
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Kiranaputri, Genoveva, Luthfiralda Sjahfirdi, and Ligaya ITA Tumbelaka. "Vaginal Smear and Neutrophil Count as an Alternative Method for Estrous Phase in Female Tiger (Panthera tigris sumatrae, Pocock, 1929)." In 3rd KOBI Congress, International and National Conferences (KOBICINC 2020). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/absr.k.210621.045.
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Sharma, Akanksha, Saritha Shamsunder, Geetika Khanna, Neeti Khunger, and Vijay Zutshi. "Chronic vulval problems: A gynaecologist’s perspective." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685355.
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Introduction: Chronic vulval symptoms are common complaints in women seeking health care and can significantly interfere with a woman’s sexual function and sense of well being. Many practitioners feel diagnostically challenged, particularly by chronic or recurrent forms of vulval disease. The aim of this study was to assess the role of various diagnostic modalities in evaluation of chronic vulval symptoms. Methods: Between August 2012 and February 2014, 100 women presenting with chronic vulval symptoms (i.e. ≥ 3 months duration) were evaluated. All of them had a thorough clinical history taken including use of vulval washes and creams, a general and gynaecological examination. Patients having chronic vaginal discharge in addition had urethral, vaginal and cervical smear and culture. All women had a careful examination of the vulva with and without magnification. Vulval scrape cytology was taken after moistening the vulva with normal saline and stained by Pap stain. Colposcopy of the vulva was then carried out after applying 5% acetic acid and 1% toluidine blue dye. Vulval biopsy was taken from suspicious areas on colposcopy and further management was based on histopathology report. Results: The mean age of women in our study was 43.57 years (range 22-80 years.), 70% women were pre-menopausal and 30% were post-menopausal. The mean duration of symptoms was 1.625 years (range 6 months - 15 years) and atypical vulval hygiene practices (excessive washing with soaps) was used in 77% of women. The commonest presenting complaint was pruritus in 92% of women; visible lesions on vulva were seen in 20%, pain in 6% and burning sensation in vulva in 5% of women. The histopathology was abnormal in 77 patients; the most common histopathological finding was non-neoplastic epithelial disorders in 64 women {Squamous cell hyperplasia (n=52), Lichen Sclerosus et atrophicus (n=6), other dermatoses including lichen Planus (n=6)}. Vulvar Intra-epithelial Neoplasia (VIN) was seen in 6 patients, 5 were squamous type VIN and 1 was non-squamous type (Paget’s disease). Squamous cell carcinoma was seen in 3 patients; malignant melanoma, benign appendiceal tumor, angiofibroma and neurofibroma in 1 patient. Examination without magnification had sensitivity of 25.97% and with magnification was 29.87% and specificity was 100% for both of them. Cytology had sensitivity and specificity of 75.32% and 86.95% respectively and sensitivity and specificity of colposcopy was 77.92% and 17.39% respectively. Conclusion: Clinical examination with and without magnification had low sensitivity but were highly specific in diagnosing vulvar lesions. A normal vulval smear and colposcopy have a high negative predictive value and are very reassuring. Colposcopy and biopsy is the gold standard for diagnosis, however clinical examination with naked eyes and magnifying glass are invaluable and can diagnose most of the neoplastic lesions.
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Tiwari, Alok, Dhananjay Gughe, Radhika Dureja, and Satinder Kaur. "Synchronous primary malignancy of ovary and cervix with different histopathology: A rare case report." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685388.
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Concurrent different histopathological types of gynecologic tumors arise rarely. We present ovarian serous and cervical squamous cell carcinoma formed synchronously. A 51-year-old woman with a poor general condition was admitted with gradual distension of abdomen for 1 year with gradual loss of weight and appetite for the last three months and pain in the abdomen and irregular vaginal bleeding for the last two months. There was no family history of malignancy of genital tract, breast or colon. On examination she was cachexic, pale, dehydrated, tachypnoeic and had edema over feet. Per abdomen examination revealed solid, non-mobile palpable mass arising from pelvis. Per vaginal examination revealed large mass in pelvis and uterus can not be felt separately on per speculum examination there was small endocervical erosion, hypertrophied cervix. On per rectal examination bilateral parametria were free. Her tumor marker were evaluated and CA-125 was found to be raised (CA 125: 915.6 u/ml U/mL); rest tumor markers were normal. Cervical punch biopsy was suggestive of moderately differentiated carcinoma and pap smear was also suggestive of cervical cancer. MRI findings revealed a mass of altered signal intensity 2.5 × 1.5 × 2.2 cm with diffusion restriction and post contrast enhancement in the anterior lip of cervix and another large, lobulated predominantly solid mass, hypo intense on T1, intermediate on T2 with diffusion restriction and post contrast enhancement in the right adnexal region abutting the small bowel and sigmoid colon optimal debulking surgery with standard protocol was done. Histopathology report revealed squamous cell carcinoma of cervix, grade III and high grade serous cystadenocarcinoma of ovary. Tumour deposits from ovary were seen on right fallopian tube and right parametrium. Squamous cell carcinoma cervix involved ectocervix, endocervix and infiltrated near full thickness of cervical stroma, endomyometrium, vaginal cuff, paracervical tissue omentum and appendix were free of tumour. Twenty five right pelvic lymphnodes dissected were free of tumour, (00/25). One out of fifteen lymphnode dissected were involved with extra capsular extent, 01/15 and thirteen para aortic lymph node dissected were free of tumor. Immunohistochemistry markers: Ovarian mass-tumour cell expressed ck, vimentin, wt-1 with focal Ck positivity, no expression of ck20, p63, ck5/6 and CEA seen. Cervical tumour-tumour cells expressed ck, ck7, p63 and ck5/6 no expression of ck20, wt-1. Based on our case report we need to keep in mind that even if patient presents with symptoms pertaining to a single malignancy; still the rare possibility of synchronous malignancies should be looked for by doing proper investigations. In our case, patient had symptoms pertaining to ovarian malignancy; whereas cervical malignancy was diagnosed after investigating the patient. Histologic examination should be done properly as the prognosis depends on the malignancies being metastatic or synchronous one appropriate management should be offered in all such cases. Long term follow up of such patients should be maintained to determine the prognosis.
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Pereira, Vanessa de Brito, Gessilda De Alcantara Nogueira De Melo, Débora De Mello Gonçales Sant’ana, and Jaqueline De Carvalho Rinaldi. "INFECÇÃO CRÔNICA POR TOXOPLASMA GONDII ALTERA O NÚMERO DE FOLÍCULOS OVARIANOS EM CAMUNDONGOS C57BL/6." In II Congresso Brasileiro de Saúde On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1423.
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Introdução: Toxoplasmose é uma parasitose de ampla distribuição causada pelo Toxoplasma gondii. Esta zoonose pode causar abortos em várias espécies, além de desencadear alterações neurológicas e oculares, porém sabe-se pouco sobre seus efeitos nos órgãos da reprodução. Objetivo: Investigar o impacto da infecção crônica pelo T. gondii sobre a quantificação dos folículos ovarianos em camundongos adultos. Material e métodos: Camundongos c C57BL/6 fêmeas foram separadas nos grupos controle (GC, n=8) e infectado (GI, n=8). Enquanto o GC recebeu salina, o GI recebeu 1000 oocistos por gavagem para indução da infecção experimental (protocolo aprovado pela CEUA/UEM sob nº 4092040517). Após 60 dias houve análise do ciclo estral dos animais pelo smear vaginal e foram eutanasiados aqueles que se encontravam em estro, fase caracterizada pela presença de células epiteliais queratinizadas. Após o aprofundamento anestésico com vapor de isoflurano os eutanasiados tiveram os ovários dissecados, pesados, processados e incluídos em parafina. Cortes de 5µm foram corados em Hematoxilina-eosina para análise da morfologia geral da gônada e quantificação dos folículos ovarianos. Os resultados foram submetidos ao teste estatístico t student e considerados significativos quando p<0,05. Resultados: A infecção crônica pelo T. gondii não afetou o peso corpóreo ou do ovário dos animais. A gônada de ambos os grupos apresentou uma organização similar, contendo região cortical constituída por epitélio germinativo, túnica albugínea, tecido conjuntivo e folículos ovarianos em diferentes estágios de desenvolvimento. A região medular apresentou-se organizada em tecido conjuntivo contendo feixe vásculo-nervoso glandular. A análise quantitativa evidenciou um aumento em 32% no número de folículos totais na cortical ovariana do GI em relação ao GC (p<0,001). Sabe-se que o T. gondii é capaz de reduzir significativamente o FSH e o LH tanto em homens quanto mulheres. Assim, uma hipótese que justifica o resultado encontrado é de que o parasito foi capaz de promover desregulação hormonal e assim afetar a maturação folicular ovariana e a ovulação. Conclusão: A infecção crônica pelo T. gondii afetou a quantidade de folículos presentes no córtex ovariano, demonstrando que a infecção pelo parasito pode afetar os estágios mais precoces da reprodução em camundongos C57BL/6 fêmeas.
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Bow, Sing T., and Xia-Fang Wang. "On the Application of Pattern Recognition and AI Technique to the Cytoscreening of Vaginal Smears by Computer." In 1989 Medical Imaging, edited by Samuel J. Dwyer III, R. Gilbert Jost, and Roger H. Schneider. SPIE, 1989. http://dx.doi.org/10.1117/12.953297.
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