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Journal articles on the topic 'Valethamate bromide'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Puram, Mounika, and Ambika Patil. "Drotaverine hydrochloride and valethamate bromide action in management of labor." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 12 (2024): 3648–53. http://dx.doi.org/10.18203/2320-1770.ijrcog20243599.

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Background: Labor duration impacts maternal and perinatal morbidity. Antispasmodics like drotaverine hydrochloride and valethamate bromide are used to shorten labor by facilitating cervical dilation. This study compares the efficacy of these drugs in labor management. Methods: A prospective study was conducted with 200 primigravida women in the active phase of labor. Participants were randomly divided into two groups: Group I received drotaverine hydrochloride (80 mg), and Group II received valethamate bromide (8 mg). Maternal and fetal outcomes, labor progression, and adverse effects were mon

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Palii, Sudhir Babu, Vijaya Lakshmi Akkupalli, and Suneetha Maddi. "The Comparative Study of Drotaverine Hydrochloride and Valethamate Bromide in First Stage of Labor." Journal of South Asian Federation of Obstetrics and Gynaecology 5, no. 2 (2013): 52–56. http://dx.doi.org/10.5005/jp-journals-10006-1223.

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ABSTRACT Objective To evaluate and compare the effects of drotaverine and valethamate on cervical dilatation. Materials and methods Total of 100 patients (aged 20 to 30 years) including both primigravidae and multigravidae in first stage of labor, were divided randomly into two groups with 50 patients in each. The drotaverine (D) and valethamate (V) groups were given intravenously, 40 mg drotaverine hydrochloride to the former with every 2 hours for a maximum of 3 doses and 8 mg valethamate bromide to the latter with maximum of 6 doses half an hour apart. Results In primigravidae and multigrav

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3

Sagar, Ram, Atul Saxena, Sharad Kumar, and Sudhir Kumar. "Clinical Study of Incomplete Cervical Dilation in Dairy Cattle and Buffaloes." Indian Journal of Veterinary Sciences and Biotechnology 17, no. 02 (2021): 99–101. http://dx.doi.org/10.21887/ijvsbt.17.2.21.

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A total of 17 clinical cases of cows and buffaloes suffering from incomplete cervical dilation (ICD) were included in the study. Among these cases, 35.29% and 64.71% cases were observed in cows and buffaloes, respectively. Pluripara were more affected as compared to primiparous animals. Treatment procedures adopted in these cases were mechanical manipulation of the cervix and a combination of four drugs (PGF2andalpha;, Betamethasone, Estrogen, and Valethamate bromide). All the animals responded to the treatment protocol. The combined hormonal treatment (PGF2andalpha;, Betamethasone, Estrogen,

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Agarwal, Shonali N., Vidhi H. Shah, Ashish V. Gokhale, and Juhi V. Amin. "Randomized control comparative study to evaluate the effect of camylofin dihydrochloride and valethamate bromide in active phase of first stage of labour." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 6 (2024): 1452–58. http://dx.doi.org/10.18203/2320-1770.ijrcog20241425.

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Background: Numerous drugs have been used to shorten the active phase of labor. Do they really shorten the duration of labor? What adverse effects do they have on the baby and the mother? These questions were the basis to perform the present study of comparing two of such drugs, injection Camylofin dihydrochloride and injection Valethamate bromide with control subjects. Aim of the study was to assess the effect of camylofin dihydrochloride and valethamate bromide on active phase of first stage of labour. Methods: This is an open label randomized controlled study of 120 eligible women with spon

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Dahal, P., B. Banerjee, DK Uprety, BP Das, A. Thakur, and A. Agrawal. "Comparative study of efficacy of drotaverine hydrochloride and valethamate bromide with control in first stage of labour." Health Renaissance 11, no. 1 (2013): 38–42. http://dx.doi.org/10.3126/hren.v11i1.7600.

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Background: Labour is the most perilous journey a woman has to undertake. Painless and short labour is desired by every woman and is a constant aim for obstetrician.Objective: To analyze and compare the efficacy and safety of drotaverine and valethamate with control group on improving cervical dilatation and promoting progress of labour. Method: Three hundred demographically similar women, both primigravida and multigravida with a term pregnancy in established labour were randomly divided into three groups. One hundred women (group 1) were given injection valethamate intramuscularly,100 women

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., Deepshikha, Monica Soni, Deepak Gupta, and Santosh Godara. "Drotaverine hydrochloride versus valethamate bromide for cervical dilatation in labour: a comparative study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 5 (2020): 1986. http://dx.doi.org/10.18203/2320-1770.ijrcog20201793.

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Background: Labor is the most perilous journey a woman has to undertake. Painless and short labor is desired by every woman and is a constant aim for obstetrician. Objective of this study was to compare the efficacy of drotaverine hydrochloride with valethamate bromide for cervical dilatation in labor in primigravida.Methods: The present study was conducted in the department of obstetrics and gynecology, S. P. Medical College and Associated Group of Hospitals, Bikaner, Rajasthan from 1st August 2018 to 31st July 2019 over a period of 1 year. Total of 300 patients were included in the study wit

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R., Sairam Aditya, Tengli Anandkumar, Ramesha, S. Chandan R., Anupama K., and M. Gurupadayya B. "Development and Validation of Stability Indicating UFLC Method for the Estimation of Anti-spasmodic Drug - Valethamate Bromide." Journal of Advances in Medical and Pharmaceutical Sciences 13, no. 3 (2017): 1–12. https://doi.org/10.9734/JAMPS/2017/26825.

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A stability indicating Ultra-Fast Liquid Chromatography (UFLC) method has been developed to estimate valethamate bromide (V&B) in tablet dosage forms and to separate analyte from other degradants and to carryout forced degradation studies. The chromatographic separation was achieved by using phenomenex kinetex 5 μ C<sub>18</sub> 100A (250x 4.6 mm) column with a flow rate of 1 mL/min in an isocratic mode with the mobile phase consisting of 0.05 M potassium dihydrogen phosphate buffer pH 7.5 (adjusted with potassium hydroxide) and acetonitrile in the ratio of 50:50. The eluents were monitore

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Thirunavukkarasu, ArunBabu, and Vijayan Sharmila. "Valethamate bromide: Conflicting evidence and continuing use." Journal of Pharmacology and Pharmacotherapeutics 1, no. 2 (2010): 120. http://dx.doi.org/10.4103/0976-500x.72365.

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9

Tuladhar, Lujaw Ratna, A. Shrestha, and R. K. Shrestha. "Adverse Drug Reaction with Hyoscine and Valethamate for Cervical Dilation during Labour." Nepal Medical College Journal 21, no. 2 (2019): 128–33. http://dx.doi.org/10.3126/nmcj.v21i2.25112.

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Adverse drug reaction (ADR) is an injury caused by taking medication. ADR may occur following single dose or prolong administration of drug or combination of two or more drugs. While major advancements of discipline of pharmacovigilance have taken place in the West, not much has been achieved in Asian countries. Labour is characterised by forceful and painful uterine contraction that result in cervical dilation and foetus decent from the birth canal. Anti-spasmodic drugs like hyoscine butylbromide and valethamate bromide have been used to accelerate cervical dilation and thus reduce the labor

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10

Sharma, J. B., P. Pundir, A. Kumar, and N. S. Murthy. "Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor." International Journal of Gynecology & Obstetrics 74, no. 3 (2001): 255–60. http://dx.doi.org/10.1016/s0020-7292(01)00448-9.

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11

Selvaraj S, Mallika, and Sumathi Natarajan. "COMPARISON OF DROTAVERINE HYDROCHLORIDE AND VALETHAMATE BROMIDE ON CERVICAL DILATATION." Journal of Evolution of Medical and Dental Sciences 5, no. 52 (2016): 3391–94. http://dx.doi.org/10.14260/jemds/2016/783.

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12

Yilmaz, Bulent, Cavit Kart, Sefa Kelekci, et al. "Meperidine versus valethamate bromide in shortening the duration of active labor." International Journal of Gynecology & Obstetrics 107, no. 2 (2009): 126–29. http://dx.doi.org/10.1016/j.ijgo.2009.06.021.

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13

Kuruvila, S., P. Jasper, A. Peedicayil, and M. Mathai. "A randomized controlled trial of valethamate bromide in acceleration of labor." International Journal of Gynecology & Obstetrics 38, no. 2 (1992): 93–96. http://dx.doi.org/10.1016/0020-7292(92)90042-h.

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14

Goswami, B., B. Goswami, M. Sarkar, and B. Biswas. "Efficacy of drotaverine and valethamate bromide in active management of labor." International Journal of Gynecology & Obstetrics 70 (2000): C37. http://dx.doi.org/10.1016/s0020-7292(00)81535-0.

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15

Sunita, Sunita, Saritha A, Hindumathi M, and Sivajyothi I. "THE COMPARATIVE STUDY OF DROTAVERINE HYDROCHLORIDE VS VALETHAMATE BROMIDE IN LABOR." Journal of Evolution of Medical and Dental Sciences 4, no. 78 (2015): 13671–79. http://dx.doi.org/10.14260/jemds/2015/1953.

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16

Jadav, Ravindra, Sachin Kalaswa, Vipul Solanki, et al. "Therapeutic and Obstetrical Management of Twin Mummified Fetuses in Surti Doe: A Case Study." Annual Research & Review in Biology 39, no. 4 (2024): 48–53. http://dx.doi.org/10.9734/arrb/2024/v39i42074.

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Fetal mummification is uncommon in small ruminants like goat and sheep. The twin mummification of fetuses confirmed by history, a clinical sign, ultrasonographical and per-vaginal examination in five year old Surti doe of fourth parity. The case was successfully managed therapeutically using intravenous administration of 3.0 ml Dexamethasone®, 20IU- Oxytocin®, 500ml-Normal saline and 30ml-Calcium magnesium borogluconate, whereas 5ml-Valethamate bromide (Epidosin®) was given intramuscularly. The goat resumed to normal appetite and appearing active and alert within a week post treatment.

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17

Mehra, Dinesh, Madhubala Chouhan, and Shatendra Goyal. "A randomized comparative study of effect of intramuscular valathemate bromide (epidosin) and intramuscular camylofin dihydrochloride (anafortan) on cervical dilatation in labour." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 12 (2021): 4488. http://dx.doi.org/10.18203/2320-1770.ijrcog20214647.

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Background: Our aim is to search for a good cervical dilating agent which is not only more efficacious in cervical dilatation but also effective in relieving pain during labour with no or very little harmful effects on mother and foetus.Methods: The type of study was simple randomized comparative study. The present study was conducted in R. N. T. Medical College, Udaipur between October 2019 and December 2020. 118 patients were selected randomly. Two groups were made each consisting of 59 patients. First group received intramuscular camylofin dihydrochloride, second group received intramuscula

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18

Ravi, Dutt Amandeep Mohit Kumar Naveen Vishal Rahul Sujata Jinagal Jasmer Dalal and Anil. "Addressing Primary Uterine Inertia Dystocia in Sows: A Therapeutic Approach." Science World a monthly e magazine 3, no. 8 (2023): 2077–79. https://doi.org/10.5281/zenodo.8275133.

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Dystocia resulting from uterine inertia is an occasional occurrence in sows. A pluriparous Large White Yorkshire (LWY) pig, aged 4 years, was presented with difficulty in the farrowing process. This difficulty persisted for the last 4 hours following the delivery of one fetus. Following a comprehensive clinico-gynaecological examination, the condition was identified as dystocia due to primary uterine inertia. To address the issue, the sow was administered a combination of therapeutic agents, including Cloprostenol, Methylergometrine, Valethamate bromide, Oxytocin, and Calcium. This treatment r

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19

Dr., Rita D., and Bhawna Bajar Dr. "Comparative Study of Normal Progression of Labour Vs use of Injection Drotaverine Hydrochloride and Injection Valethamate Bromide on Cervical Dilatation and Progression of Labour." International Journal of Innovative Science and Research Technology (IJISRT) 9, no. 12 (2024): 1557–62. https://doi.org/10.5281/zenodo.14565211.

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Objective: To compare the normal progression of labour vs use of injection Drotaverine Hydrochloride and injection Valethamate Bromide on cervical dilatation and progression of labour.  Method: This prospective randomised study was conducted in obstetrics and gynecology department at Navodaya Medical College Hospital and Research Centre , Raichur involved 100 pregnant women admitted to labour room for delivery during the study period of one year . Written informed consent was taken. After taking history, general and obstetrics examination was done and contracted pelvis was ruled out. Group I

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20

Kocak, A., O. Aldemir, M. Turgal, and S. Erkaya. "Effect of valethamate bromide in accelerating labor: a prospective randomized controlled trial." Clinical and Experimental Obstetrics & Gynecology 45, no. 5 (2018): 767–72. http://dx.doi.org/10.12891/ceog4477.2018.

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21

Kalaswa, Sachin, Ravindra Jadav, Keshav, et al. "Therapeutic with Obstetrical Management to Deliver Live Three Male Foetuses in a Surti Doe." Advances in Research 25, no. 3 (2024): 117–21. http://dx.doi.org/10.9734/air/2024/v25i31056.

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Dystocia is common occurrence in small ruminants like goat and sheep. A case tentatively diagnosed as a foetal dystocia due to foetal dorso-pubic position and malpostures of foetus in seven year old surti doe based on the history, clinical signs and vaginal examination. The present case described a successful delivery of three live male foetuses by obstetrical mutational approach following therapeutically intravenous administration of 20IU- Oxytocin, 30ml-calcium borogluconate and 500ml Normal saline, whereas 5ml valethamate bromide and antihistamine were administered intramuscularly. Supporti

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22

Khan Mandal, Aparna, and Nargis Molla. "Comparison of efficacy of Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour: a hospital based randomized trial." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 4 (2018): 1579. http://dx.doi.org/10.18203/2320-1770.ijrcog20181359.

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Background: Labour is a process of contraction with the goal of producing progressive cervical effacement and dilatation in order to expel the uterine foetus from the intrauterine to the extra-uterine environment. The objective of this study was to compare the efficacy and safety of drotaverine hydrochloride and valethamate bromide for shortening the duration of labour.Methods: This randomized trial was conducted at R. G. Kar Medical College over one year. Total 360 primigravida or multigravidae mothers satisfying the criteria of having singleton term pregnancy with cephalic presentation with

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23

Gitanjali, B. "Valethamate bromide: Is there any proof of efficacy and safety for its use in labor?" Journal of Pharmacology and Pharmacotherapeutics 1, no. 1 (2010): 2. http://dx.doi.org/10.4103/0976-500x.64528.

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24

Madhu, Chendrimada, Suvarna Mahavarkar, and Sudhir Bhave. "A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour." Archives of Gynecology and Obstetrics 282, no. 1 (2009): 11–15. http://dx.doi.org/10.1007/s00404-009-1188-8.

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Köstü, B., G. Kiran, Ö. Ercan, et al. "A randomised controlled study comparing valethamate bromide and placebo in shortening the duration of active labour." Journal of Obstetrics and Gynaecology 36, no. 2 (2015): 196–99. http://dx.doi.org/10.3109/01443615.2015.1041883.

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26

Aditya, R., Anandkumar Tengli, Ramesha, R. Chandan, K. Anupama, and B. Gurupadayya. "Development and Validation of Stability Indicating UFLC Method for the Estimation of Anti-spasmodic Drug - Valethamate Bromide." Journal of Advances in Medical and Pharmaceutical Sciences 13, no. 3 (2017): 1–12. http://dx.doi.org/10.9734/jamps/2017/26825.

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SURBHI, SAINI, BALWINDER KAUR, and ARVINDER KAUR. "COMPARISON OF EFFECT OF DROTAVARINE WITH HYOSCINE-N-BUTYL BROMIDE AND VALETHAMATE ON RATE OF CERVICAL DILATATION." International Journal of Scientific & Engineering Research 8, no. 6 (2017): 1806–16. http://dx.doi.org/10.14299/ijser.2017.06.006.

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28

Jadav, Ravindra, Sachin Kalaswa, Keshav, et al. "Obstetrical Management of Dystocia Due to Uterine Torsion and Faulty Disposition of Foetus in Banni Buffalo." International Journal of Biochemistry Research & Review 33, no. 5 (2024): 63–69. http://dx.doi.org/10.9734/ijbcrr/2024/v33i5876.

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A Banni buffalo in 3rd parity was presented with the history of completed gestation period and violent straining for more than forty eight hours without any progress in calving. On per-vaginum and per-rectum revealed dystocia due to 180° post-cervical right sided uterine torsion. Caudal epidural anesthesia was applied by injecting 5 ml of 2% lignocaine and the animal was calmed down with 0.2 ml xylazine (IV) and cast on the side of torsion because highly furious and uncontrol or unable to restrained, then the rolling was applied as described by Modified Schaffer‘s detorsion method. After secon

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Kalaswa, Sachin, Ravindra Jadav, Janak Panchal, et al. "Cesarean Sectional as a Treatment of Dystocia Caused by Uterine Torsion in Mehsana Buffalo." Annual Research & Review in Biology 39, no. 5 (2024): 1–7. http://dx.doi.org/10.9734/arrb/2024/v39i52076.

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A case of dystocia due to post-cervical right side uterine torsion with the history of colic and straining since (days) in a pluriparous Mehsana buffalo was presented at the clinics of Veterinary Gynaecology and Obstetrics of Veterinary College, Sardarkrushinagar, Dantiwada, Gujarat, India. Maternal dystocia due to of uterine torsion was diagnosed by history, a clinical sign, per rectal and per vaginal examinations. At first we used modified Schaffer’s method for management of uterine torsion in buffalo. After the three rolls torsion was detorted successfully, but due to insufficient dilated c

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30

Vijaya, Chaganti, and Deepa x. "A Comparative Study on the Efficacy of Drotaverine Hydrochloride and Valethamate Bromide on Cervical Dilatation in Active Phase of Labour in Tertiary Care Hospital." International Journal of Science and Research (IJSR) 11, no. 11 (2022): 798–802. http://dx.doi.org/10.21275/sr221111192600.

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31

YADAV, RISHIPAL, GYAN SINGH, POOJA YADAV, et al. "Comparative evaluation of valethamate bromide and hyoscine butyl bromide on cervical dilatation in water buffaloes after detorsion." Indian Journal of Animal Sciences 93, no. 3 (2023). http://dx.doi.org/10.56093/ijans.v93i3.131037.

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After detorsion, incomplete cervical dilatation is major cause of dystocia. The present study aimed to investigate the comparative efficacy of valethamate bromide and hyoscine butyl bromide on cervical dilation after detorsion and their effect on haematological and biochemical parameters of torsion detorted water buffaloes. A total of 18 buffaloes were selected for study which were divided into three groups of six animals each. After detorsion by Sharma’s Modified Schaffer’s method, animals with grade I and grade II cervix were selected for the study. Group I (control group) buffaloes were adm

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32

Jha, Archana, Satyendra Kumar, [Prof ]. Usha Kumari, and Debarshi Jana. "TO COMPARE THE EFFICACY OF DROTAVERINE HYDROCHLORIDE AND VALETHAMATE BROMIDE IN SHORTENING OF THE FIRST STAGE OF LABOUR AT OBSTETRICS AND GYNAECOLOGY DEPARTMENT OF JLNMCH, BHAGALPUR, BIHAR." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, February 1, 2021, 80–82. http://dx.doi.org/10.36106/ijsr/3633120.

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Background: To compare the efcacy of Drotaverine Hydrochloride and Valethamate Bromide in shortening of the rst stage of Labor. Drotaverine is more effective in regards of shorten the 1st stage of labor, rate of cervical dilatation with less side effects in compare to Valethamate Bromide. Methods:Two Hundred demographically similes woman with full term pregnancy in active labour were included in the study and divided into two groups viz. First Group: 100 women were given injection Drotaverine Hydrochloride (Drotin) 40 mg intramuscularly at 3-4 cm dilation at two hour interval. Second Group:

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S, Dev,, Sultana, I, Dey, T, and B. C. Sutradhar. "Management of incomplete cervical dilation in a Jersey crossbreed cow." Bangladesh Journal of Veterinary and Animal Sciences, August 22, 2016. http://dx.doi.org/10.60015/bjvas/v04i1_2a2.

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A pluriparous Jersey crossbreed cow was presented in the Large Animal Obstetrics out Patient Unit of Madras Veterinary College Teaching Hospital, TANUVAS, Tamilnadu, India with the history of labour pain. Defecation and urination was normal. The case was diagnosed as improper dilation of cervix and was treated with Cloprostenol Sodium, Dexamethasone and Valethamate bromide. Per-vaginal examination revealed an indurated cervix with no fetal movement. The dead fetus was removed by snare fetotomy under tranquilization and local analgesia. The cow had normal appetite after five days of postoperati

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Shah, Samipa, Shuchi Patel, Shuchi Patel, and Pankti Jayswal. "Comparative Study of Drotaverine Hydrochloridand Valethamate Bromide in Rate of Cervical Dilatation." Indian journal of applied basic medical sciences 29, no. 20B (2017). http://dx.doi.org/10.26860/ijabms.2017.29.20b.7.

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Changede, Pradnya. "Comparison of injection drotaverine and injection valethamate bromide on duration and course of labor." International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016, 1836–42. http://dx.doi.org/10.18203/2320-1770.ijrcog20161673.

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36

Saini, Surbhi. "Effect of Drotavarine Hydrochloride and A Combination of - Hyoscine–NButyl Bromide With Valethamate Bromide on the Duration of Active Phase of Labor - A Comparative Study." journal of medical science and clinical research 5, no. 9 (2017). http://dx.doi.org/10.18535/jmscr/v5i9.74.

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Jogi, Sangeeta. "To compare the efficacy of Drotaverine hydrochloride and Valethamate bromide in shortening of the first stage of labour." International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2015, 1038–43. http://dx.doi.org/10.18203/2320-1770.ijrcog20150402.

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Sarbhjit, Kaur. "To Compare the Effect of Camylofin Dihydrochloride (Anafortin) with Combination of Valethamate Bromide (Epidosin) and Hyoscine Butyl-N-Bormide (Buscopan) on Cervical Dilation." JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013. http://dx.doi.org/10.7860/jcdr/2013/6231.3345.

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