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Dissertations / Theses on the topic 'Valproate de sodium'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Rumbach, Lucien. "Valproate de sodium et métabolisme de l'ammoniaque." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1BH16.

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2

Bromley, Rebecca. "Prenatal exposure to sodium valproate and levetiracetam : consequences for neurodevelopmental outcomes?" Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/prenatal-exposure-to-sodium-valproate-and-levetiracetam-consequences-for-neurodevelopmental-outcomes(441de36f-0499-4f2c-bb9f-ab1f8d53b26e).html.

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Research has demonstrated that prenatal exposure to antiepileptic drugs is associated with an increased risk of physical malformations. The potential risk such exposure conveys to the developing brain and therefore the later cognitive functioning of the child is now the focus of both national and international research. This thesis investigated the relationship between prenatal exposure to antiepileptic drugs and child cognitive functioning. This investigation was undertaken in three phases: a systematic review of the published literature; an original research piece investigating prenatal expo

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3

Pétriat, Marie-Anne. "L'enfant de mère sous valproate." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25132.

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4

Hirsch, Edouard. "Hyperammoniémie induite par les glucides chez l'homme traité par le valproate de sodium." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR1M292.

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5

BEAL, ALINE. "Intoxications massives par le valproate de sodium : a propos d'un cas avec coma prolonge." Lyon 1, 1991. http://www.theses.fr/1991LYO1M025.

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6

BONNETON, VOLPI JOELLE. "Interaction medicamenteuse entre deux antiepileptiques majeurs : la carbamazepine et le valproate de sodium ; etude experimentale et clinique." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX22963.

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7

Astar, Blanchard Isabelle. "Essai dépakine - tegretol dans les épilepsies partielles : étude multicentrique française." Bordeaux 2, 1988. http://www.theses.fr/1988BOR23013.

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8

Yip, Fung-ping, and 葉鳳萍. "Comparison of hormone profiles in Chinese adult epilepsy patients treated with Sodium Valproate or lamotrigine monotherapy: a prospective randomised trial." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B4175797X.

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9

Yip, Fung-ping. "Comparison of hormone profiles in Chinese adult epilepsy patients treated with Sodium Valproate or lamotrigine monotherapy a prospective randomised trial /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4175797X.

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10

Turner, Susan Langston. "Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to the anticonvulsant drug sodium valproate /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487598303837757.

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11

Komulainen, T. (Tuomas). "Disturbances in mitochondrial DNA maintenance in neuromuscular disorders and valproate-induced liver toxicity." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207230.

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Abstract Mitochondrial DNA depletion and deletions are related to mutations in the nuclear genes responsible for replication and maintenance of mitochondrial DNA (mtDNA). The POLG1 gene encodes the enzyme responsible for replication of mtDNA. A particular feature of the POLG1 mutations is an increased risk of acute liver failure (ALF) upon exposure to sodium valproate (VPA), but the pathomechanism is not resolved. The present work studies the molecular genetic aetiology and clinical phenotypes associated with mtDNA depletion and deletion. Another objective was an investigation of clinical phen

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12

Souza, Maria Sigride Thomé de. "Coadministração lamotrigina e valproato de sódio em crianças e adolescentes com epilepsia refratária: estudo clínico." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-25042012-091422/.

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A associação de ácido valpróico/ divalproato de sódio e lamotrigina tem se mostrado eficaz no tratamento das epilepsias refratárias, tendo como limitador ao seu uso os efeitos adversos, principalmente numa população de crianças e adolescentes, onde esses efeitos são maximizados. Este estudo clínico tem como objetivo avaliar as propriedades farmacológicas da associação valproato/divalproato de sódio e lamotrigina em uma população pediátrica refratária ao tratamento medicamentoso usando método de introdução e escalonamento mais lento do que o preconizado, com seguimento prolongado. Para tal, foi

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13

Hynynen, J. (Johanna). "Status epilepticus in mitochondrial diseases and the role of POLG1 variants in the valproic-acid induced hepatotoxicity." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526224244.

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Abstract Various genetic aetiologies — including mitochondrial diseases, chromosomal disorders, and other monogenic diseases — are involved in status epilepticus (SE), a common neurologic emergency occurring in children and adults that exhibits high rates of morbidity and mortality. The exact frequency of mitochondrial SE is currently undefined. Furthermore, patients with pathogenic variants of POLG1 encoding mitochondrial DNA polymerase gamma have an increased risk of acute liver failure (ALF) induced by the common antiepileptic drug, valproic acid (VPA), which is problematic due to these pat

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14

Kuntz-Simon, Gaëlle. "Implication des variations de la concentration intracellulaire en thiols dans la reactivation du virus de l'immunodeficience humaine et du cytomegalovirus humain : effet du valproate de sodium sur la multiplication de ces virus." Université Louis Pasteur (Strasbourg) (1971-2008), 1995. http://www.theses.fr/1995STR13097.

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Comme decrit dans la litterature, nous confirmons que la n-acetyl-l-cysteine (nac), precurseur de glutathion (gsh), inhibe la transactivation de la sequence ltr ainsi que la multiplication du virus de l'immunodeficience humaine (vih) dans des cellules chroniquement infectees. Cependant, nous montrons que ces inhibitions sont independantes de l'augmentation du taux de gsh intracellulaire puisque d'autres precurseurs de gsh, tels l'oxothiazolidine 4-carboxylate ou l'homocysteine, ne produisent pas les memes effets, mais au contraire, stimulent la multiplication du vih. Par ailleurs, une augmenta

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15

Pillans, Peter Ian. "A study of acetylcholinesterase and cholinesterase in the fetal mouse brain and a study of the effects of three teratogens, vitamin A, cyclophosphamide and sodium valproate on the fetal mouse central nervous system." Doctoral thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/27212.

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There were two aims in this thesis. Firstly, to investigate cholinesterase and its isoenzymes in the fetal mouse brain, and secondly to study drug-induced fetal damage with the following objectives in mind: (i) to examine new markers for the evaluation and prediction of the teratogenic potential of drugs, and (ii) to try and throw more light on pathogenic mechanisms of drug injury with particular reference to the developing fetal central nervous system. Acetylcholinesterase activity in brain homogenates was determined colorimetrically and the isoenzymes were separated by polyacrylamide gel ele

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16

Seabi, Mmakgomo Eunice. "Formulation of carbamazepine and sodium valproate fixed dose combination for management of epilepsy." Thesis, 2019. http://hdl.handle.net/10386/3084.

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Thesis ((M. Pharm. (Pharmaceutics)) -- University of Limpopo, 2019<br>Epilepsy is the fourth most common neurological disorder after migraine, stroke and Alzheimer’s disease and it affects about fifty million people worldwide. Careful consideration should be taken when deciding to initiate treatment in epilepsy as it should consider the balance between the possibility of further seizures and their associated risks, including the possible risk of sudden expected death, inconvenience and the risks of taking regular medication for each individual. In the early 1980’s, the first-line treatment for

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17

Chen, YungChang, and 陳永昌. "The Effect of Sodium Valproate to Hepatic Metabolic Rate of Lamotrigine: in vitro study." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/68250039933161428220.

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碩士<br>國立臺灣大學<br>藥學研究所<br>87<br>Lamotrigine, 3,5-diamino-6-(2,3,dichlorophenyl-1,2,4-triazine), is a new antiepileptic drug. It is structurally unrelated to the major antiepileptic agents in current use, and is believed to exert its antiepileptic effect by inhibiting the release of excitatory neurotransmitters. Lamotrigine is a stable white powder with the solubility in water of less than 1 mg/ml and in ethanol of 1 mg/ml. It is well absorbed after oral administration and has absolute oral bioavailability of 98%. The pharmacokinetics of lamotrigine conform to a one compartment model.

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