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Relevant bibliographies by topics / Valve interstitial cells / Dissertations / Theses

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Dissertations / Theses on the topic 'Valve interstitial cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Rattazzi, Marcello. "Contribution of Interstitial Valve Cells to Aortic Valve Calcification." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425639.

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Background. The traditional view of aortic valve calcification as a slow, ineluctable event has been recently questioned by evidence showing the importance of a balance between promoting and inhibiting factors, and the relevance of osteogenic cellular-driven processes. The aortic valve leaflets are comprised of a heterogeneous population of interstitial cells (VIC) whose specific contribution to the degenerating valve has not been defined yet. Aim. The major aim is to identify and describe the phenotypic characteristics of a subpopulation of aortic VIC able to acquire a pro-calcific profile

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2

Heaney, Allison Mahoney. "Culture and phenotype of canine valvular interstitial cells." Thesis, Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/319.

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3

Salhiyyah, Kareem. "The role of hypoxia on interstitial mitral valve cells." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/41078.

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Mitral valve disease is a multifactorial process. The valve is a complex structure that contains an amalgam of extracellular proteins, cellular components, nerves and blood vessels. It is predicted that some of the central portions of the valve leaflets could exist under hypoxic conditions. Hypoxia could play a role in initiating the structural changes in the valve that lead to dysfunction of the valve. It is known to cause the up-regulation of hypoxia-induced factor (HIF) that can regulate the differentiation of cells, the production of extracellular matrix (ECM) and expression of matrix remo

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4

Poggio, P. "THE ROLE OF VALVE INTERSTITIAL CELLS IN THE PATHOGENESIS OF CALCIFIC AORTIC VALVE DISEASE." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229415.

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Calcific aortic valve disease (CAVD) is the most common etiology of acquired aortic valve disease. The early stage is characterized by thickening of the leaflets and none or marginal effect on the mechanical properties of the valve, while the end stage disease is associated with impaired leaflet motion and resistances to blood flow. These conditions are known as aortic valve sclerosis (AVSc) and calcific aortic valve stenosis (AVS), respectively. AVSc is present in 25–30% of patients over 65 years of age and in up to 40% of those over 75 years of age. Moreover, since AVSc hemodynamics are comp

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5

Adesanya, T. M. Ayodele. "MG53 protein protects aortic valve interstitial cells from membrane injury and fibrocalcific remodeling." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534515427092756.

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6

Butcher, Jonathan Talbot. "The Effects of Steady Laminar Shear Stress on Aortic Valve Cell Biology." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/4824.

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Aortic valve disease (AVD) affects millions of people of all ages around the world. Current treatment for AVD consists of valvular replacement with a non-living prosthetic valve, which is incapable of growth, self-repair, or remodeling. While tissue engineering has great promise to develop a living heart valve alternative, success in animal models has been limited. This may be attributed to the fact that understanding of valvular cell biology has not kept pace with advances in biomaterial development. Aortic valve leaflets are exposed to a complex and dynamic mechanical environment unlike

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7

Cirka, Heather Ann. "Mechanical Regulation of Apoptosis and Calcification within Valvular Interstitial Cells." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-dissertations/213.

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Calcific aortic valvular disease (CAVD) is the most common valvular pathology in the developed world. CAVD results in calcifications forming on the aortic valve leaflets, inhibiting proper closure and causing complications of stenosis and regurgitation. Although, the mechanisms behind the disease initiation are unknown, it is believed to be a cell-mediated phenomenon, and not the result of passive degradation of the valve as once believed due to the increased prevalence with age. Currently, there are no pharmaceutical options for the prevention or reversal of calcifications, the only treatment

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8

Smith, Sally. "Characterisation of the forces generated by human heart valve interstitial cells : relevance to tissue engineering." Thesis, University of Westminster, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434306.

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9

Liu, Mengmeng. "Tissue-engineered canine mitral valve constructs as in vitro research models for myxomatous mitral valve disease." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10060.

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Myxomatous mitral valve disease (MMVD) is one of the most common degenerative cardiac diseases affecting humans and dogs; however, its pathogenesis is not completely understood. This study focussed on developing tissue-engineered fibrin based canine mitral valve constructs, which can be used as an in vitro platform to study the pathogenesis of MMVD. Prior to three dimensional (3D) construct fabrication, primary canine mitral valve endothelial cells (VECs) and valve interstitial cells (VICs) were isolated, cultured and characterized utilising a variety of techniques. Moreover, preliminary exper

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10

Dye, Bailey Katherine. "Cellular Mechanisms of VIC Activation in Mitral Valve Prolapse." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1594995213439086.

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11

Shayhidin, Elnur Elyar. "Evaluation of quinazolin-4-piperidine sulfamides as inhibitors of human NPP1 : relevance in the treatment of pathologic mineralization of valve interstitial cells." Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/26750.

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Le rétrécissement valvulaire aortique calcifié (RAC) est le trouble valvulaire le plus fréquent chez les personnes âgées des pays développés. La seule option de traitement possible le remplacement de la valve aortique. L'identification du rôle de l’enzyme ecto-nucleotidase NPP1 dans le processus de calcification suggère que cette enzyme pourrait être une cible potentielle pour le développement d'un inhibiteur pharmacologique contre la calcification de la valve aortique. Jusqu’à présent, les composés qui ont été développés en tant qu'inhibiteurs de NPP1 manquent de puissance et de spécificité.

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12

Boroomand, Seti. "Valvular interstitial cell transformation : implications for aortic valve calcification." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/47138.

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Aortic valve stenosis (AVS) involves the transformation of valvular interstitial cells (VIC) into an osteoblastic phenotype. Such valvular disease is mostly associated with both thickening and calcification of the valve cusps, which is accompanied by inflammation and remodeling of the tissue. This process is mediated by the VIC that carry out an impressive array of functions throughout the calcification process. For this dissertation, I hypothesized that in AVS, VIC transform from a myofibroblast phenotype to osteoblast-like cells and that the canonical Wnt and TGFβ pathways and vitamin D3 int

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13

Hinds, Heather C. "Evaluating terminal differentiation of porcine valvular interstitial cells in vitro." Link to electronic thesis, 2006. http://www.wpi.edu/Pubs/ETD/Available/etd-050506-113014/.

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14

Throm, Quinlan Angela M. "Mechanical Activation of Valvular Interstitial Cell Phenotype: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/640.

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During heart valve remodeling, and in many disease states, valvular interstitial cells (VICs) shift to an activated myofibroblast phenotype which is characterized by enhanced synthetic and contractile activity. Pronounced alpha smooth muscle actin (αSMA)-containing stress fibers, the hallmark of activated myofibroblasts, are also observed when VICs are placed under tension due to altered mechanical loading in vivo or during in vitro culture on stiff substrates or under high mechanical loads and in the presence of transforming growth factor-beta1 (TGF-β1). The work presented herein describes th

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15

Kural, Mehmet Hamdi. "Regulating Valvular Interstitial Cell Phenotype by Boundary Stiffness." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-dissertations/303.

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"A quantitative understanding of the complex interactions between cells, soluble factors, and the biological and mechanical properties of biomaterials is required to guide cell remodeling towards regeneration of healthy tissue rather than fibrocontractive tissue. The goal of this thesis was to elucidate the interactions between the boundary stiffness of three-dimensional (3D) matrix and soluble factors on valvular interstitial cell (VIC) phenotype with a quantitative approach. The first part of the work presented in this thesis was to characterize the combined effects of boundary stiffness and

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16

Cui, Lin Lin. "Investigating the role of matrix vesicles during aortic valve interstitial cell calcification." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31182.

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Vascular calcification is a prominent cardiovascular condition found worldwide. This condition is predominantly found in the elderly population, and patients who suffer from chronic kidney disease, due to an imbalance of serum phosphate and calcium levels. For many years, vascular calcification was believed to be a passive pathological process which develops with ageing and/or lifestyle. Little has been documented about the disease until the 20th century, when interest in cardiovascular research grew amongst scientists. Indeed, vascular calcification underpins severe clinical outcomes and card

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17

Han, Richard I.-Ming. "Morphological, cellular and proteomic features of canine myxomatous mitral valve disease." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4286.

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Myxomatous mitral valve degeneration (MMVD) is the single most common cardiac disease of the dog, and is analogous to Mitral Valve Prolapse in humans. Very little is known about the aetiopathogenesis of this disease or the changes in valvular interstitial cell populations in diseased valves. The aim of this study was to identify morphological, cellular and molecular changes associated with MMVD. Mitral valve leaflets from both normal and varying grades (Whitney’s 1-4) of diseased dogs were subject to image analysis, immunophenotyping, proteomics and RT-PCR. Image analysis - leaflet thickening

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18

Ambrose, Emma. "Characterization of autologous cell sources for alternatives to aortic valvular interstitial cells in tissue engineered heart valves." 2016. http://hdl.handle.net/1993/31804.

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The gold standard treatment for patients with AVD is surgical replacement of the aortic valve with either mechanical or fixed tissue prostheses. These implants have a limited lifespan and are associated with serious adverse events. Patient autologous tissue engineered heart valves (TEHVs) offer a solution. Vital to the development of a TEHV is determining a source of donor tissue(s) that most closely mimics the native valve tissue. In pursuit of determining an alternative cell source for patient autologous TEHVs we compared a number of phenotypic and genotypic characteristics of atrial fibrobl

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19

Liu, Haijiao. "Mechanical Characterization of Aortic Valve Interstitial Cells and their Nuclei using Atomic Force Microscopy." Thesis, 2012. http://hdl.handle.net/1807/33306.

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The cellular mechanical environment, including the elasticity of the extracellular matrix, profoundly affects cellular mechanical and biological responses. This responsiveness depends on and may influence the inherent mechanical properties of the cell and the nucleus. In this thesis, the local and global elastic moduli of valve interstitial cells (VICs) cultured on substrates of varying stiffness were characterized using atomic force microscopy (AFM). A novel AFM technique used to directly determine nuclear elastic moduli in situ was also tested and preliminary results for VIC nuclear elastici

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20

Watt, Derek Randall. "The Effects of Mechanical Loading on the Local Myofibrogenic Differentiation of Aortic Valve Interstitial Cells." Thesis, 2008. http://hdl.handle.net/1807/10442.

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Calcific aortic valve sclerosis is characterized by focal lesions in the valve leaflet. These lesions are rich in myofibroblasts that express α-SMA and cause fibrosis. Lesions tend to occur in regions of the leaflet that are subjected to large bending loads, suggesting a mechanobiological basis for myofibrogenic differentiation and valve pathogenesis. In this thesis, a bioreactor was developed to study the effect of physiological loading on myofibrogenic differentiation of valve interstitial cells. Cyclic loading of native porcine aortic valve leaflets ex vivo resulted in increased α-SMA expre

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21

Fayet, Cristina. "Role of cardiac valve interstitial cells in valve repair : deposition of fibronectin and formation of fibrillar adhesions in response to injury." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=95135&T=F.

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22

Yip, Cindy Ying Yin. "Pathology of Calcific Aortic Valve Disease: The Role of Mechanical and Biochemical Stimuli in Modulating the Phenotype of and Calcification by Valvular Interstitial Cells." Thesis, 2010. http://hdl.handle.net/1807/26520.

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Calcific aortic valve disease (CAVD) occurs through multiple mutually non-exclusive mechanisms that are mediated by valvular interstitial cells (VICs). VICs undergo pathological differentiation during the progression of valve calcification; however the factors that regulate cellular differentiation are not well defined. Most commonly recognized are biochemical factors that induce pathological differentiation, but little is known regarding the biochemical factors that may suppress this process. Further, the contribution of matrix mechanics in valve pathology has been overlooked, despite increas

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23

Chen, Jan-Hung. "Roles of Matrix Mechanics in Regulating Aortic Valve Interstitial Cell Pathological Differentiation." Thesis, 2011. http://hdl.handle.net/1807/31716.

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Calcific aortic valve disease (CAVD) is associated with increased presence of myofibroblasts, osteoblastic cells and, occasionally, adipocytes and chondrocytes in lesions. The ectopic cell types in diseased valves may be elaborated by an unidentified multipotent progenitor subpopulation within the valve interstitial cells (VICs) that populate the valve interstitium. Notably, lesions form preferentially in the fibrosa layer, the stiffer layer of the valve leaflet. It has been shown that differentiation of VICs to myofibroblasts and osteoblasts is modulated by matrix stiffness. However, the

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24

Xu, Songyi. "Valve Interstitial Cell Activation and Proliferation are Associated with Changes in Beta-catenin." Thesis, 2012. http://hdl.handle.net/1807/32290.

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Heart valve interstitial cells (VICs) undergo activation and proliferation in repair and disease, but the mechanisms are not fully understood. We hypothesize that the establishment of N-cadherin/β-catenin cell-cell contacts may decrease VIC activation, and that Wnt3a/β-catenin signaling may increase VIC proliferation. VIC cultures of different densities are stained for α-SMA, cofilin, TGF-β, pSmad2/3, N-cadherin and β-catenin, and probed for phospho-β-catenin by Western blot. Low density VIC cultures are treated with exogenous Wnt3a and measured for cell number, proliferation, apoptosis, α-SMA

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25

Tseng, Hubert. "The characterization of the microstructure of the aortic valve for tissue engineering applications." Thesis, 2013. http://hdl.handle.net/1911/72051.

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The aortic valve maintains unidirectional blood flow between the left ventricle and the systemic circulation. When diseased, the valve is replaced either by a mechanical or a bioprosthetic heart valve, that carry issues such as thrombogenesis, long term structural failure, and calcification, necessitating the development of more structurally and biologically sufficient long-term replacements. Tissue engineering provides a possible avenue for development, combining cells, scaffolds, and biochemical factors to regenerate tissue. The overall goal of this dissertation was to create a foundation fo

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26

Zhao, Ruogang. "The Development and Application of Tools to Study the Multiscale Biomechanics of the Aortic Valve." Thesis, 2012. http://hdl.handle.net/1807/33866.

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Calcific aortic valve disease (CAVD) is one of the most common causes of cardiovascular disease in North America. Mechanical factors have been closely linked to the pathogenesis of CAVD and may contribute to the disease by actively regulating the mechanobiology of valve interstitial cells (VICs). Mechanical forces affect VIC function through interactions between the VIC and the extracellular matrix (ECM). Studies have shown that the transfer of mechanical stimulus during cell-ECM interaction depends on the local material properties at hierarchical length scales encompassing tissue, cell and cy

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