Academic literature on the topic 'Vanderbilt University. Center for Lung Research'

e14047 Background: There is currently a lack of easily-accessible data regarding the volume and type of cancer patients seen at VUMC, despite extensive use of an electronic medical record (EMR) with a dedicated tumor registry. This leads to errors in estimating metrics that depend on subject accrual to clinical trials. We aimed to develop a tool to determine the number of head and neck squamous cell carcinoma (HNSCC) patients, stratified by desired subsets, seen yearly at the VUMC in order to achieve a more accurate and efficacious approach to estimating future patient accrual to clinical trials. Methods: Working with Nashville Biosciences, we identified patients with HNSCC using ICD codes in combination with VUMC’s Tumor Registry data (collected for patients diagnosed and treated at VUMC). We estimated the rate of accrual of HNSCC patient blood samples (a proxy for ICD code) based on the number of specimens acquired over the past 3 years. Each patient was counted only once based on their first blood sample acquired during this period, based on a comprehensive list of laboratories and clinical procedures that require a specimen to be drawn. We then evaluated the distribution of patients by primary site, standardized to SEER registry terminology. We also investigated what fraction of patients received treatment with surgery, radiation, and/or chemotherapy (we expect that this includes treatment with biologics) using a combination of ICD9/10 and CPT coding. Results: We identified a total of 1,131 HNSCC patients. SEER summary staging information was available for 603 patients - 432 (72%) had Stage 1-3 disease and 171 (28%) had Stage 4 disease. Primary site data was available for 717 patients - 648 (90%) HNSCC of the oral cavity, 20 (3%) had HNSCC of the oropharynx, 29 (4%) HNSCC of the larynx, 20 (3%) HNSCC of the hypopharynx. Of all patients, we found that 598 had at least 1 code for chemotherapy, 540 for radiotherapy, and 825 for surgery such that the majority (96%) received cancer treatment. We have not evaluated the timing of the treatment relative to diagnosis. Conclusions: By using ICD codes and tumor registry data extracted from VUMC’s EMR, we determined the site distribution and type of treatment for HNSCC over a 3-year period. The disease site distribution did not match prior experience Refinements are ongoing. However, once improved, these methods may be used to estimate future clinical trial accrual, thus reducing start-up time, cost and poor trial site performance, while increasing accrual.

This discussion was moderated by Michael McGoon, MD, Professor of Medicine and Consultant in the Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota. Participants included members of the Editorial Advisory Board of Advances in Pulmonary Hypertension: Victor F. Tapson, MD, Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, and Editor-in-Chief of the journal; Richard N. Channick, MD, Associate Professor of Medicine, Pulmonary and Critical Care Division, University of California, San Diego Medical Center, San Diego, California; Vallerie V. McLaughlin, MD, Associate Professor of Medicine, Director, Pulmonary Hypertension Program, University of Michigan Health System, Ann Arbor, Michigan; Ronald J. Oudiz, MD, Associate Professor of Medicine, UCLA School of Medicine, and Director, Liu Center for Pulmonary Hypertension, Division of Cardiology, Harbor-UCLA Medical Center, Torrance, California; and Ivan M. Robbins, MD, Director, Pulmonary Hypertension Center, Vanderbilt University, Nashville, Tennessee.

Journal of Mathematics Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated.Many authors, regardless of whether Journal of Mathematics Research publishes their work, appreciate the helpful feedback provided by the reviewers.Reviewers for Volume 9, Number 6 Cinzia Bisi, Ferrara University, ItalyGuy Biyogmam, Georgia College & State University, USAJalal Hatem, Baghdad University, IraqKong Liang, University of Illinois at Springfield, USAKuldeep Narain Mathur, University Utara Malaysia, MalaysiaMaria Alessandra Ragusa, University of Catania, ItalyMaria Cecília Santos Rosa, Instituto Politecnico da Guarda, PortugalMohammad A. AlQudah, German Jordanian University, JordanN. V. Ramana Murty, Andhra Loyola College, IndiaRami Ahmad El-Nabulsi, Athens Institute for Education and Research, GreeceSanjib Kumar Datta, University of Kalyani, IndiaShenghua Ni, Vanderbilt University Medical Center, USAXinyun Zhu, University of Texas of the Permian Basin, USAYaqin Feng, Ohio University, USAYifan Wang, University of Houston, USAYoussef El-Khatib, United Arab Emirates University, United Arab Emirates Sophia WangOn behalf of,The Editorial Board of Journal of Mathematics ResearchCanadian Center of Science and Education

Journal of Mathematics Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated.Many authors, regardless of whether Journal of Mathematics Research publishes their work, appreciate the helpful feedback provided by the reviewers.Reviewers for Volume 9, Number 5 Arman Aghili, University of Guilan, IranEnrico Jabara, Universita di Ca Foscari, ItalyJingbo Xia, Huazhong agricultural Univ, ChinaKhalil Ezzinbi, Cadi Ayyad University, MoroccoKuldeep Narain Mathur, University Utara Malaysia, MalaysiaLuca Di Persio, University of Verona, ItalyMaria Alessandra Ragusa, University of Catania, ItalyOmur Deveci, Kafkas University, TurkeyÖzgür Ege, Celal Bayar University, TurkeyRami Ahmad El-Nabulsi, Athens Institute for Education and Research, GreeceRovshan Bandaliyev, National Academy of Sciences of Azerbaijan, AzerbaijanSaima Anis, Comsats Institute of Information Technology, PakistanSanjib Kumar Datta, University of Kalyani, IndiaSelcuk Koyuncu, University of North Georgia, USASergiy Koshkin, University of Houston Downtown, USAShenghua Ni, Vanderbilt University Medical Center, USAVishnu Narayan Mishra, Sardar Vallabhbhai National Institute of Technology, IndiaZhongming Wang, Florida International University, USAZoubir Dahmani, University of Mostaganem, Algeria Sophia WangOn behalf of,The Editorial Board of Journal of Mathematics ResearchCanadian Center of Science and Education

A panel of experts convened by telephone on April 20, 2011 to discuss their experiences and recommendations regarding diagnosis and management of patients with Group 2 PH. The conversation was facilitated by Myung Park, MD, Associate Professor of Medicine and Director, Pulmonary Vascular Disease Program, Division of Cardiology at University of Maryland School of Medicine and guest editor of this issue. The participants were Rene Alvarez, MD, Associate Professor of Medicine and Director, Advanced Heart Failure/Pulmonary Hypertension Outreach Program, University of Pittsburgh School of Medicine; Teresa De Marco, MD, Professor of Medicine, Director, Heart Failure and Pulmonary Hypertension Program and Director, Heart Transplantation, University of California San Francisco Medical Center; Marc Semigran, MD, Medical Director of the Heart Failure and Cardiac Transplant Program at the Massachusetts General Hospital Center and Associate Professor of Medicine at Harvard Medical School; and Ivan Robbins, MD, Assistant Professor of Medicine and Director, Lung Transplant Program, Vanderbilt University Medical Center.

Abstract Introduction: Pregnant women with sickle cell disease (SCD) are at increased risk for both pregnancy and SCD related morbidity and mortality. At the Korle-Bu Teaching Hospital (KBTH), a national referral center in Accra, Ghana, the estimated maternal mortality ratio of women with and without SCD is 8,300 and 690 per 100,000 live births respectively (US, general population, maternal mortality ratio 14 per 100, 000 live births). In 2015, a multi-disciplinary obstetric SCD team was formed comprising obstetricians, hematologists, pulmonologists and nurses. In a before and after study design, we tested the hypothesis that implementing a multi-disciplinary team for care of pregnant women with SCD would significantly decrease maternal mortality. Methodology: The study received ethical approval from the Ethical and Protocol Review Committee, College of Health Sciences, University of Ghana Institutional Review Board and Vanderbilt University Medical Center (Data Coordinating Center (DCC). The pre-intervention period was from January 2014 to April 2015, and the post intervention period was May 2015 to May 2016. During the intervention period, members of the multi-disciplinary team evaluated participants at enrollment, during outpatient visits and during acute illnesses (inpatient and outpatient). Simple protocols were implemented for preventing and treating Acute Chest Syndrome (ACS). Balloons were purchased (substituted for incentive spirometry devices) and used routinely during management of acute pain episodes and after surgery. Multiple pulse oximetry machines were integrated into routine clinical practice for monitoring of oxygen desaturation. Close maternal and fetal monitoring were implemented. During the pre-intervention period, pregnant women were admitted to multiple wards throughout the hospital. Post-intervention, pregnant women were primarily admitted to two designated wards at the Obstetrics Department, for better coordinated care. All participants in the post-intervention period were followed from enrollment until six weeks postpartum. Members of the clinical research team and DCC adjudicated every vaso-occlusive pain episode, ACS episode, and acute event requiring hospitalization. Pain was defined as an acute episode, unrelated to labor and requiring hospitalization. ACS was defined based on the presence of at least 2 of the following criteria: fever, increased respiratory rate, chest pain, pulmonary auscultatory findings, increased O2 requirement or new radiodensity on chest roentgenogram. Results: A total of 154 and 91 deliveries by women with SCD were evaluated in the pre- and post-intervention period, respectively. The median age for cases in the pre-intervention period was 29 (range 18- 43) years. The median age for cases in post-intervention period was 29 (range 18-41) years and 35 participants had hemoglobin SSand 56had HbSC. Among the 91 participants, rates of pain and ACS were 194.6 (64/32.89) and 42.6 (14/32.89) events per 100 patient-years, respectively. Median gestational age at enrollment was 24 (range 7 - 40) weeks. Median gestational age at delivery was 38 (range 26 - 41) weeks. Perinatal mortality rates pre- and post-intervention were 74.3 per 1000 total births (11/ 148 X 1000) and 54.9 per 1000 total births (5/91 X 1000) respectively. Maternal mortality pre- and post-intervention were 9.7% (15 of 154) and 1.1% (1 of 91) of total deliveries respectively. The maternal mortality ratio pre- and post-intervention were 10,949 (15/137) and 1,163 (1/86) per 100,000 live births respectively. Cause of death pre-intervention period included: cardiopulmonary disease-60.0%, preeclampsia-6.67%, acute kidney injury-6.67%, severe anemia-20.0%, hypovolemic shock-6.67%. During the post-intervention period, the only death was an autopsy confirmed massive pulmonary embolism four days postpartum. Conclusion: In a low and middle income setting, a multidisciplinary team approach to care of pregnant women with SCD can dramatically decrease maternal mortality, as well as perinatal mortality. Further strategies must be employed to decrease the SCD related maternal mortality and perinatal mortality rates to levels expected in the non-SCD population and to implement multi-disciplinary SCD obstetric teams in other regions. Disclosures Asare: Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Adomakoh:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Olayemi:Intramural University of Ghana Research fund: Research Funding; Vanderbilt University Medical Center Gift Funds: Research Funding. Mensah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Ghansah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Osei- Bonsu:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Crabbe:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Musah:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Hayfron- Benjamin:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Boafor:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. Kassim:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding. James:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research Fund: Research Funding. Oppong:Vanderbilt University Medical Center Gift Funds: Research Funding; Intramural University of Ghana Research fund: Research Funding.

Journal of Mathematics Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated.Many authors, regardless of whether Journal of Mathematics Research publishes their work, appreciate the helpful feedback provided by the reviewers.Reviewers for Volume 9, Number 2 Alberto Simoes, University of Beira Interior, PortugalAli Berkol, Space and Defense Technologies & Baskent University, TurkeyArman Aghili, University of Guilan, IranCecilia Maria Fernandes Fonseca, Polytechnic of Guarda, PortugalGane Sam Lo, Universite Gaston Berger de Saint-Louis, SenegalMarek Brabec, Academy of Sciences of the Czech Republic, Czech RepublicMaria Alessandra Ragusa, University of Catania, ItalyMohammad Sajid, Qassim University, Saudi ArabiaMohd Hafiz, Universiti Sains Malaysia, , MalaysiaN. V. Ramana Murty, Andhra Loyola College, IndiaOlivier Heubo-Kwegna, Saginaw Valley State University, USAOmur Deveci, Kafkas University, TurkeyÖzgür Ege, Celal Bayar University, TurkeyPeng Zhang, State University of New York at Stony Brook, USAPhilip Philipoff, Bulgarian Academy of Sciences, BulgariaRovshan Bandaliyev, National Academy of Sciences of Azerbaijan, AzerbaijanSanjib Kumar Datta, University of Kalyani, IndiaSelcuk Koyuncu, University of North Georgia, USASergiy Koshkin, University of Houston Downtown, USAShenghua Ni, Vanderbilt University Medical Center, USAVishnu Narayan Mishra, Sardar Vallabhbhai National Institute of Technology, IndiaWaleed Al-Rawashdeh, Montana Tech, USAYifan Wang, University of Houston, USAYoussef Ei Foutayeni, Modeling and Simulation Laboratory Lams Hassan II University, MoroccoYoussef El-Khatib, United Arab Emirates University, United Arab EmiratesZoubir Dahmani, University of Mostaganem, Algeria Sophia WangOn behalf of,The Editorial Board of Journal of Mathematics ResearchCanadian Center of Science and Education

Journal of Mathematics Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated. Many authors, regardless of whether Journal of Mathematics Research publishes their work, appreciate the helpful feedback provided by the reviewers. Reviewers for Volume 11, Number 3   Abdessadek Saib, University of Tebessa, Algeria Arman Aghili, University of Guilan, Iran Cinzia Bisi, Ferrara University, Italy Gabriela Ciuperca, University Lyon 1, France Gener Santiago Subia, NUeva Ecija University of Science and Technology, Philippines Kong Liang, University of Illinois at Springfield, USA Kuldeep Narain Mathur, University Utara Malaysia, Malaysia Maria Alessandra Ragusa, University of Catania, Italy Rami Ahmad El, Athens Institute for Education and Research, Greece Rovshan Bandaliyev, National Academy of Sciences of Azerbaijan, Azerbaijan Sanjib Kumar Datta, University of Kalyani, India Shenghua Ni, Vanderbilt University Medical Center, USA Sreedhara Rao Gunakala, The University of The West Indies, Trinidad and Tobago Xiaofei Zhao, Texas A&M University, United States Yaqin Feng, Ohio University, USA Yifan Wang, University of Houston, USA   Sophia Wang On behalf of, The Editorial Board of Journal of Mathematics Research Canadian Center of Science and Education

Chapter 5 examines how Samuel P. Hayes, Jr., an early Point Four official who later helped design the Peace Corps, tried to “use” the University of Michigan to establish a program of multidisciplinary organized research on economic development, the Center for Research on Economic Development (CRED). The resistance he encountered from university administrators and economics department colleagues suggests that traditional academic norms did not always yield completely to interdisciplinary organized research. Yet the establishment of CRED, which had parallels at the University of Chicago, Vanderbilt, and Yale, suggests the importance of economic development as a focus for organized research in the instrumental university. This chapter also provides an account of the new subfield of development economics and of the relationship between the economics discipline and the behavioral science paradigm.

Abstract Primary blast injury (PBI), which relates gross blast-related trauma or traces of injury in air-filled tissues or those tissues adjacent to air-filled regions (rupture/lesions, contusions, hemorrhaging), has been documented in a number of marine mammal species after blast exposure [1, 2, 3]. However, very little is known about marine mammal susceptibility to PBI except in rare cases of opportunistic studies. As a result, traditional techniques rely on analyses using small-scale terrestrial mammals as surrogates for large-scale marine mammals. For an In-house Laboratory Independent Research (ILIR) project sponsored by the Office of Naval Research (ONR), researchers at the Naval Undersea Warfare Center, Division Newport (NUWCDIVNPT), have undertaken a broad 3-year effort to integrate computational fluid-structure interaction techniques with marine mammal anatomical structure. The intent is to numerically simulate the dynamic response of a marine mammal thoracic cavity and air-filled lungs to shock loading, to enhance understanding of marine mammal lungs to shock loading in the underwater environment. In the absence of appropriate test data from live marine mammals, a crucial part of this work involves code validation to test data for a suitable surrogate test problem. This research employs a surrogate of an air-filled spherical membrane structure subjected to shock loading as a first order approximation to understanding marine mammal lung response to underwater explosions (UNDEX). This approach incrementally improves upon the currently used one-dimensional spherical air bubble approximation to marine mammal lung response by providing an encapsulating boundary for the air. The encapsulating structure is membranous, with minimal simplified representation not accounting for marine mammal species-specific and individual animal differences in tissue composition, rib mechanics, and mechanical properties of interior lung tissue. NUWCDIVNPT partnered with the Naval Submarine Medical Research Laboratory (NSMRL) to design and execute a set of experiments to investigate the shock response of an air-filled rubber dodgeball in a shallow underwater environment. These tests took place in the 2.13 m (7-ft) diameter pressure tank at the University of Rhode Island, with test measurements including pressure data and digital image correlation (DIC) data captured with high-speed cameras in a stereo setup. The authors developed 3-dimensional computational models of the dodgeball experiments using Dynamic System Mechanics Advanced Simulation (DYSMAS), a Navy fluid-structure interaction code. DYSMAS models of a variety of different problems involving submerged pressure vessel structures responding to hydrostatic and/or UNDEX loading have been validated against test data [4]. Proper validation of fluid structure interaction simulations is quite challenging, requiring measurements in both the fluid and structure domains. This paper details the development of metrics for comparison between test measurements and simulation results, with a discussion of potential sources of uncertainty.