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Journal articles on the topic 'Vanillin biosynthesis'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Dong, Zeyu, Shaoguan Zhao, Yizhang Xing, et al. "Time-Series Metabolome and Transcriptome Analyses Reveal the Genetic Basis of Vanillin Biosynthesis in Vanilla." Plants 14, no. 13 (2025): 1922. https://doi.org/10.3390/plants14131922.

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Vanillin, the principal aromatic compound in vanilla, is primarily derived from mature pods of vanilla (Vanilla planifolia Andrews). Although the biosynthetic pathway of vanillin has been progressively elucidated, the specific key enzymes and transcription factors (TFs) governing vanillin biosynthesis require further comprehensive investigation via combining transcriptomic and metabolomic analysis. For this study, V. planifolia (higher vanillin producer) and V. imperialis (lower vanillin producer) were selected. Time-series metabolomics analysis revealed 160–220 days after pollination (DAPs) a

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2

Cai, Yingying, Fenglin Gu, Yinghua Hong, Yonggan Chen, Fei Xu, and Kejing An. "Metabolite Transformation and Enzyme Activities of Hainan Vanilla Beans During Curing to Improve Flavor Formation." Molecules 24, no. 15 (2019): 2781. http://dx.doi.org/10.3390/molecules24152781.

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This paper compares the differences in metabolites of vanilla beans at five different curing stages. Key vanilla flavors, vanillin precursors and main enzymes during the curing process of Hainan vanilla beans were also analyzed. Hundreds of metabolites were detected based on metabolic analyses of a widely targeted metabolome technique, compared with blanched vanilla beans (BVB), sweating vanilla beans (SVB) and drying vanilla beans (DVB), the total peak intensity of cured vanilla beans (CVB) is on the rise. The score plots of principal component analysis indicated that the metabolites were gen

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3

Santos, Luísa D. F., Sylvie Lautru, and Jean-Luc Pernodet. "Genetic Engineering Approaches for the Microbial Production of Vanillin." Biomolecules 14, no. 11 (2024): 1413. http://dx.doi.org/10.3390/biom14111413.

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Vanilla flavour is widely used in various industries and is the most broadly used flavouring agent in the food industry. The demand for this flavour is, therefore, extremely high, yet vanilla bean extracts can only meet about 1% of the overall demand. Vanillin, the main constituent of vanilla flavour, can easily be obtained through chemical synthesis. Nonetheless, consumer demands for natural products and environmentally friendly industrial processes drive the development of biotechnological approaches for its production. Some microorganisms can naturally produce vanillin when fed with various

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4

Hansen, Esben H., Birger Lindberg Møller, Gertrud R. Kock, et al. "De Novo Biosynthesis of Vanillin in Fission Yeast (Schizosaccharomyces pombe) and Baker's Yeast (Saccharomyces cerevisiae)." Applied and Environmental Microbiology 75, no. 9 (2009): 2765–74. http://dx.doi.org/10.1128/aem.02681-08.

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ABSTRACT Vanillin is one of the world's most important flavor compounds, with a global market of 180 million dollars. Natural vanillin is derived from the cured seed pods of the vanilla orchid (Vanilla planifolia), but most of the world's vanillin is synthesized from petrochemicals or wood pulp lignins. We have established a true de novo biosynthetic pathway for vanillin production from glucose in Schizosaccharomyces pombe, also known as fission yeast or African beer yeast, as well as in baker's yeast, Saccharomyces cerevisiae. Productivities were 65 and 45 mg/liter, after introduction of thre

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5

Negishi, Osamu, Kenji Sugiura, and Yukiko Negishi. "Biosynthesis of Vanillin via Ferulic Acid in Vanilla planifolia." Journal of Agricultural and Food Chemistry 57, no. 21 (2009): 9956–61. http://dx.doi.org/10.1021/jf901204m.

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6

Jiang, Wankui, Xiaoyue Chen, Yifan Feng, et al. "Current Status, Challenges, and Prospects for the Biological Production of Vanillin." Fermentation 9, no. 4 (2023): 389. http://dx.doi.org/10.3390/fermentation9040389.

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Vanillin has been widely used as a flavoring agent in the food industry and as a precursor in the medicine and polymer industries. However, the use of chemically synthesized vanillin is prohibited in food and some other industries. Additionally, the harsh conditions and toxic substrates in chemically synthesized vanillin lead to some environmental challenges and energy waste. With the rapid development of synthetic biology, the biological production of vanillin from renewable resources through microbial fermentation has gained great attention owing to its high selectivity and environmentally f

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7

Ye, Qi, Weizhuo Xu, Yanan He, et al. "Biosynthesis of Vanillin by Rational Design of Enoyl-CoA Hydratase/Lyase." International Journal of Molecular Sciences 24, no. 17 (2023): 13631. http://dx.doi.org/10.3390/ijms241713631.

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Vanillin holds significant importance as a flavoring agent in various industries, including food, pharmaceuticals, and cosmetics. The CoA-dependent pathway for the biosynthesis of vanillin from ferulic acid involved feruloyl-CoA synthase (Fcs) and enoyl-CoA hydratase/lyase (Ech). In this research, the Fcs and Ech were derived from Streptomyces sp. strain V-1. The sequence conservation and structural features of Ech were analyzed by computational techniques including sequence alignment and molecular dynamics simulation. After detailed study for the major binding modes and key amino acid residue

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8

Walton, Nicholas J., Arjan Narbad, CraigB Faulds, and Gary Williamson. "Novel approaches to the biosynthesis of vanillin." Current Opinion in Biotechnology 11, no. 5 (2000): 490–96. http://dx.doi.org/10.1016/s0958-1669(00)00125-7.

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9

Ignea, Codruta, Anastasia Athanasakoglou, Efstathia Ioannou, et al. "Carnosic acid biosynthesis elucidated by a synthetic biology platform." Proceedings of the National Academy of Sciences 113, no. 13 (2016): 3681–86. http://dx.doi.org/10.1073/pnas.1523787113.

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Synthetic biology approaches achieving the reconstruction of specific plant natural product biosynthetic pathways in dedicated microbial “chassis” have provided access to important industrial compounds (e.g., artemisinin, resveratrol, vanillin). However, the potential of such production systems to facilitate elucidation of plant biosynthetic pathways has been underexplored. Here we report on the application of a modular terpene production platform in the characterization of the biosynthetic pathway leading to the potent antioxidant carnosic acid and related diterpenes in Salvia pomifera and Ro

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10

Qiu, Di, Minghai Wang, Chao Zhou, Jinyu Zhao, and Genlin Zhang. "De novo biosynthesis of vanillin in engineered Saccharomyces cerevisiae." Chemical Engineering Science 263 (December 2022): 118049. http://dx.doi.org/10.1016/j.ces.2022.118049.

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11

Cai, Shun-Ju, Jia-Chun Lin, Min-Yu Wang, Xiao-Jun Ji, and Zhi-Gang Zhang. "Biosynthesis of vanillin from vanillyl alcohol by recombinant Escherichia coli cells expressing 5-hydroxymethylfurfural oxidase." Industrial Crops and Products 204 (November 2023): 117285. http://dx.doi.org/10.1016/j.indcrop.2023.117285.

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12

Zhu, Daochen, Lingxia Xu, Sivasamy Sethupathy, et al. "Decoding lignin valorization pathways in the extremophilic Bacillus ligniniphilus L1 for vanillin biosynthesis." Green Chemistry 23, no. 23 (2021): 9554–70. http://dx.doi.org/10.1039/d1gc02692e.

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13

Yang, Hailian, Jaime Barros-Rios, Galina Kourteva, et al. "A re-evaluation of the final step of vanillin biosynthesis in the orchid Vanilla planifolia." Phytochemistry 139 (July 2017): 33–46. http://dx.doi.org/10.1016/j.phytochem.2017.04.003.

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14

Lu, Xin-Yi, Xiao-Mei Wu, Bao-Di Ma, and Yi Xu. "Enhanced Thermostability of Pseudomonas nitroreducens Isoeugenol Monooxygenase by the Combinatorial Strategy of Surface Residue Replacement and Consensus Mutagenesis." Catalysts 11, no. 10 (2021): 1199. http://dx.doi.org/10.3390/catal11101199.

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Vanillin has many applications in industries. Isoeugenol monooxygenase (IEM) can catalyze the oxidation of isoeugenol to vanillin in the presence of oxygen under mild conditions. However, the low thermal stability of IEM limits its practical application in the biosynthesis of natural vanillin. Herein, two rational strategies were combined to improve the thermostability of IEM from Pseudomonas nitroreducens Jin1. Two variants (K83R and K95R) with better thermostability and one mutant (G398A) with higher activity were identified from twenty candidates based on the Surface Residue Replacement met

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15

Hansen, Chad A. "Vanillin biosynthesis from sucrose ex-sugarcane: authentication of an alternative vanillin source through stable isotope data analysis." Heliyon 7, no. 5 (2021): e06970. http://dx.doi.org/10.1016/j.heliyon.2021.e06970.

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16

Marrano, Nicola, Rosaria Spagnuolo, Giuseppina Biondi, et al. "Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival." Plants 10, no. 2 (2021): 286. http://dx.doi.org/10.3390/plants10020286.

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Extra virgin olive oil (EVOO) is a major component of the Mediterranean diet and is appreciated worldwide because of its nutritional benefits in metabolic diseases, including type 2 diabetes (T2D). EVOO contains significant amounts of secondary metabolites, such as phenolic compounds (PCs), that may positively influence the metabolic status. In this study, we investigated for the first time the effects of several PCs on beta-cell function and survival. To this aim, INS-1E cells were exposed to 10 μM of the main EVOO PCs for up to 24 h. Under these conditions, survival, insulin biosynthesis, gl

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17

Gallage, Nethaji J., and Birger Lindberg Møller. "Vanillin–Bioconversion and Bioengineering of the Most Popular Plant Flavor and Its De Novo Biosynthesis in the Vanilla Orchid." Molecular Plant 8, no. 1 (2015): 40–57. http://dx.doi.org/10.1016/j.molp.2014.11.008.

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18

Kunjapur, Aditya M., and Kristala L. J. Prather. "Development of a Vanillate Biosensor for the Vanillin Biosynthesis Pathway in E. coli." ACS Synthetic Biology 8, no. 9 (2019): 1958–67. http://dx.doi.org/10.1021/acssynbio.9b00071.

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19

Kelly, Christine, Opal Jones, Christopher Barnhart, and Curtis Lajoie. "Effect of Furfural, Vanillin and Syringaldehyde on Candida guilliermondii Growth and Xylitol Biosynthesis." Applied Biochemistry and Biotechnology 148, no. 1-3 (2008): 97–108. http://dx.doi.org/10.1007/s12010-007-8103-1.

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20

Wu, Weihua, Fang Liu, and Seema Singh. "Toward engineeringE. coliwith an autoregulatory system for lignin valorization." Proceedings of the National Academy of Sciences 115, no. 12 (2018): 2970–75. http://dx.doi.org/10.1073/pnas.1720129115.

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Efficient lignin valorization could add more than 10-fold the value gained from burning it for energy and is critical for economic viability of future biorefineries. However, lignin-derived aromatics from biomass pretreatment are known to be potent fermentation inhibitors in microbial production of fuels and other value-added chemicals. In addition, isopropyl-β-d-1-thiogalactopyranoside and other inducers are routinely added into fermentation broth to induce the expression of pathway enzymes, which further adds to the overall process cost. An autoregulatory system that can diminish the aromati

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21

Acosta Lopez, Manuel J., Eva Trevisson, Marcella Canton, et al. "Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6." Oxidative Medicine and Cellular Longevity 2019 (July 10, 2019): 1–11. http://dx.doi.org/10.1155/2019/3904905.

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Coenzyme Q (CoQ), a redox-active lipid, is comprised of a quinone group and a polyisoprenoid tail. It is an electron carrier in the mitochondrial respiratory chain, a cofactor of other mitochondrial dehydrogenases, and an essential antioxidant. CoQ requires a large set of enzymes for its biosynthesis; mutations in genes encoding these proteins cause primary CoQ deficiency, a clinically and genetically heterogeneous group of diseases. Patients with CoQ deficiency often respond to oral CoQ10 supplementation. Treatment is however problematic because of the low bioavailability of CoQ10 and the poo

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22

Kłosowski, Grzegorz, and Dawid Mikulski. "Impact of Lignocellulose Pretreatment By-Products on S. cerevisiae Strain Ethanol Red Metabolism during Aerobic and An-aerobic Growth." Molecules 26, no. 4 (2021): 806. http://dx.doi.org/10.3390/molecules26040806.

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Understanding the specific response of yeast cells to environmental stress factors is the starting point for selecting the conditions of adaptive culture in order to obtain a yeast line with increased resistance to a given stress factor. The aim of the study was to evaluate the specific cellular response of Saccharomyces cerevisiae strain Ethanol Red to stress caused by toxic by-products generated during the pretreatment of lignocellulose, such as levulinic acid, 5-hydroxymethylfurfural, furfural, ferulic acid, syringaldehyde and vanillin. The presence of 5-hydroxymethylfurfural at the highest

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23

Varman, Arul M., Lian He, Rhiannon Follenfant, et al. "Decoding how a soil bacterium extracts building blocks and metabolic energy from ligninolysis provides road map for lignin valorization." Proceedings of the National Academy of Sciences 113, no. 40 (2016): E5802—E5811. http://dx.doi.org/10.1073/pnas.1606043113.

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Sphingobiumsp. SYK-6 is a soil bacterium boasting a well-studied ligninolytic pathway and the potential for development into a microbial chassis for lignin valorization. An improved understanding of its metabolism will help researchers in the engineering of SYK-6 for the production of value-added chemicals through lignin valorization. We used13C-fingerprinting,13C metabolic flux analysis (13C-MFA), and RNA-sequencing differential expression analysis to uncover the following metabolic traits: (i) SYK-6 prefers alkaline conditions, making it an efficient host for the consolidated bioprocessing o

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24

Chen, Qi Hang, Dao Tao Xie, Shan Qiang, Ching Yuan Hu, and Yong Hong Meng. "Developing efficient vanillin biosynthesis system by regulating feruloyl-CoA synthetase and enoyl-CoA hydratase enzymes." Applied Microbiology and Biotechnology 106, no. 1 (2021): 247–59. http://dx.doi.org/10.1007/s00253-021-11709-w.

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25

Fock-Bastide, Isabelle, Tony Lionel Palama, Séverine Bory, Aurélie Lécolier, Michel Noirot, and Thierry Joët. "Expression profiles of key phenylpropanoid genes during Vanilla planifolia pod development reveal a positive correlation between PAL gene expression and vanillin biosynthesis." Plant Physiology and Biochemistry 74 (January 2014): 304–14. http://dx.doi.org/10.1016/j.plaphy.2013.11.026.

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26

Mishra, Sonali, Shilpi Singh, Arif Ali, et al. "Microwave-assisted Single Step Cinnamic Acid Derivatization and Evaluation for Cytotoxic Potential." Current Pharmaceutical Biotechnology 21, no. 3 (2020): 236–43. http://dx.doi.org/10.2174/1389201020666191015161429.

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Background: Phenylpropylene biosynthesis pathway plays a crucial role in the vanillin and their derivative(s) production in the plants. The intermediate of vanillin synthesis i.e. cinnamic acid (CA) is converted into 2-Hydroxy 4-MethoxyBenzaldehyde (HMB) in Decalepis arayalpathra having a number of therapeutic value. Objective : Microwave-assisted modifications in cinnamic acid were planned for potential anticancer properties with better yield and efficiency. The present study also confirms the presence of HMB and its precursor i.e. cinnamic acid in D. arayalpathra tubers. Methods: We used a s

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27

Latif, Sajid, Paul A. Weston, Russell A. Barrow, Saliya Gurusinghe, John W. Piltz, and Leslie A. Weston. "Metabolic Profiling Provides Unique Insights to Accumulation and Biosynthesis of Key Secondary Metabolites in Annual Pasture Legumes of Mediterranean Origin." Metabolites 10, no. 7 (2020): 267. http://dx.doi.org/10.3390/metabo10070267.

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Annual legumes from the Mediterranean region are receiving attention in Australia as alternatives to traditional pasture species. The current study employed novel metabolic profiling approaches to quantify key secondary metabolites including phytoestrogens to better understand their biosynthetic regulation in a range of field-grown annual pasture legumes. In addition, total polyphenol and proanthocyanidins were quantified using Folin–Ciocalteu and vanillin assays, respectively. Metabolic profiling coupled with biochemical assay results demonstrated marked differences in the abundance of coumes

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Zheng, Dongyun, Chengguo Hu, Tian Gan, Xueping Dang, and Shengshui Hu. "Preparation and application of a novel vanillin sensor based on biosynthesis of Au–Ag alloy nanoparticles." Sensors and Actuators B: Chemical 148, no. 1 (2010): 247–52. http://dx.doi.org/10.1016/j.snb.2010.04.031.

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29

Yang, Gui-Ying, Gao-Wei Zheng, Bu-Bing Zeng, Jian-He Xu, and Qi Chen. "Engineering of halide methyltransferases for synthesis of SAE and its application in biosynthesis of ethyl vanillin." Molecular Catalysis 550 (November 2023): 113533. http://dx.doi.org/10.1016/j.mcat.2023.113533.

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30

Li, Qi, Linghui Kong, Yu-Cai He та Cuiluan Ma. "Efficient biosynthesis of vanillylamine via biological transamination of lignin-derived vanillin in a β-cyclodextrin-water medium". Sustainable Chemistry and Pharmacy 38 (квітень 2024): 101437. http://dx.doi.org/10.1016/j.scp.2024.101437.

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31

Liao, Jieren, Veronika Lederer, Alba Bardhi, et al. "Acceptors and Effectors Alter Substrate Inhibition Kinetics of a Plant Glucosyltransferase NbUGT72AY1 and Its Mutants." International Journal of Molecular Sciences 24, no. 11 (2023): 9542. http://dx.doi.org/10.3390/ijms24119542.

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One of the main obstacles in biocatalysis is the substrate inhibition (SI) of enzymes that play important roles in biosynthesis and metabolic regulation in organisms. The promiscuous glycosyltransferase UGT72AY1 from Nicotiana benthamiana is strongly substrate-inhibited by hydroxycoumarins (inhibitory constant Ki < 20 µM), but only weakly inhibited when monolignols are glucosylated (Ki > 1000 µM). Apocarotenoid effectors reduce the inherent UDP-glucose glucohydrolase activity of the enzyme and attenuate the SI by scopoletin derivatives, which could also be achieved by mutations. Here, we

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32

Zhao, Xinyue, Yuting Zhang, Hanyi Jiang, et al. "Efficient vanillin biosynthesis by recombinant lignin-degrading bacterium Arthrobacter sp. C2 and its environmental profile via life cycle assessment." Bioresource Technology 347 (March 2022): 126434. http://dx.doi.org/10.1016/j.biortech.2021.126434.

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33

Iqbal, Husna, Muhammad Imran, Adnan Shahzad, et al. "Inhibition Potential of Schiff Bases Against the Target Enzymes of Mycobacterium Tuberculosis Using Molecular Docking." Journal of Microbiological Sciences 4, no. 01 (2025): 84–96. https://doi.org/10.38211/jms.2025.04.124.

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Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (MT), an acid-fast, gram-positive bacillus that poses a major global health threat. Despite the availability of first-line and second-line anti-TB drugs, TB remains one of the top causes of mortality from infectious diseases, particularly in low- and middle-income countries. The emergence of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains has significantly reduced the efficacy of existing treatment regimens, highlighting the urgent need to discover and develop novel therapeutic agents

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34

Chen, Long, Purna Kumar Khatri, Mauro Paolini та ін. "Authentic Aroma and Compound-Specific Isotope Ratios (δ13C, δ2H) Profiles of Vanilla Pods (V. planifolia and V. tahitensis)". Molecules 30, № 4 (2025): 825. https://doi.org/10.3390/molecules30040825.

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Stable isotope ratio analysis of carbon (δ13C) and hydrogen (δ2H) in vanillin has become a valuable tool for differentiating natural vanilla from synthetic or biosynthetic alternatives and for tracing its geographical origins. However, increasingly sophisticated fraud techniques necessitate ongoing refinement of analytical methods to ensure accurate detection. This study advanced the field by investigating minor volatile organic compounds as potential biomarkers for identifying botanical and geographical origins of vanilla products. Vanilla pods from the two main vanilla species, V. planifolia

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Hirayama, Haruka, Takuya Akiyama, Satoshi Kimura та ін. "Influence of the p-hydroxyphenyl/guaiacyl ratio on the biphenyl and β-5 contents in compression wood lignins". Holzforschung 73, № 10 (2019): 923–35. http://dx.doi.org/10.1515/hf-2019-0012.

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Abstract Reaction woods of three softwoods, Pinus merkusii, Cryptomeria japonica and Cedrus deodara, were investigated by alkaline nitrobenzene oxidation (NBO) to characterize the condensed-type structures in compression wood lignins. A novel biphenyl-type NBO product carrying guaiacyl (G)- and p-hydroxyphenyl (H)-units, dehydrovanillin-p-hydroxybenzaldehyde (HG-biphenyl product), was identified using the authentic standard compound. On the basis of the yield of this novel NBO product, as well as those of GG-biphenyl-, β-5-, and uncondensed-type products [e.g. dehydrodivanillin, 5-formylvanill

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36

Li, Qian, Xiaoman Zhu, Ying Zhao, and Yanli Xie. "The antifungal activity of o-vanillin against Aspergillus flavus via disrupting ergosterol biosynthesis and promoting oxidative stress, and an RNA-seq analysis thereof." LWT 164 (July 2022): 113635. http://dx.doi.org/10.1016/j.lwt.2022.113635.

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37

Li, Qian, Xiaoman Zhu, Ying Zhao, and Yanli Xie. "The antifungal activity of o-vanillin against Aspergillus flavus via disrupting ergosterol biosynthesis and promoting oxidative stress, and an RNA-seq analysis thereof." LWT 164 (July 2022): 113635. http://dx.doi.org/10.1016/j.lwt.2022.113635.

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Cao, Bo, Junzhi Lin, Zhenfeng Wu, et al. "Mechanisms exploration of Xiaojin Pills on lung cancer based on metabolomics and network pharmacology." Journal of Pharmacy and Pharmacology 73, no. 8 (2021): 1071–79. http://dx.doi.org/10.1093/jpp/rgab050.

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Abstract Objectives This study was designed to evaluate the pharmacological activity and therapeutic mechanism of Xiaojin Pills (XJW) on lung cancer. Methods Mice were orally administered with Xiaojin Pills for 21 days. Tumour samples were collected to evaluate the antilung cancer effect, and blood samples were collected to identify differential metabolites with metabolomics. Through the analysis of network pharmacology, the active ingredients and targets related to XJW therapy for lung cancer were filtered. Key findings Different expression of seven metabolites related to seven pathways, incl

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Istyastono, Enade Perdana, Rr Sri Untari Siwi S.M.P, Andreas Asdi Utama, and Supardjan A.M. "SYNTHESIS NEW POTENTIAL ANTI-INFLAMMATORY AGENT SODIUM SALT OF PENTAGAMAVUNON-0." Indonesian Journal of Chemistry 4, no. 3 (2010): 180–85. http://dx.doi.org/10.22146/ijc.21850.

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Inflammation is the response of living tissues to injury. The process affects physiological changes such as erythema, edema, asthma and fever. Non-steroid Anti-inflammatory Drugs (NSAIDs) have been developed since they could inhibit inflammation process because of its ability to inhibit biosynthesis of prostaglandin, one of inflammation mediators, through inhibition of cyclooxigenase (COX) enzymes. Molecules, which have been reported having anti-inflammatory activity, for example, are curcumin, some curcumin derivatives and curcumin analogues. One of curcumin analogues that has been developed

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Abdelgawad, Fatma Alzahra M., Seham S. El-Hawary, Essam M. Abd El-Kader, et al. "Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E." Plants 12, no. 15 (2023): 2813. http://dx.doi.org/10.3390/plants12152813.

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Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential −19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, qu

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Heng, Ding, Min Zhang, Yuhan Yuan, and Xinyun Qiu. "Alteration of Colonic Bacterial and Fungal Composition and Their Inter- and Intra-Kingdom Interaction in Patients with Adenomas with Low-Grade Dysplasia." Microorganisms 11, no. 5 (2023): 1327. http://dx.doi.org/10.3390/microorganisms11051327.

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Colorectal cancer (CRC) develops from pre-cancerous cellular lesions in the gut epithelium and mainly originates from specific types of colonic adenomas with dysplasia. However, gut microbiota signatures among sampling sites in patients with colorectal adenomas with low-grade dysplasia (ALGD) and normal control (NC) remain uncharacterized. To characterize gut microbial and fungal profiles in ALGD and normal colorectal mucosa tissues. We used 16S and ITS1-2 rRNA gene sequencing and bioinformatics analysis on the microbiota of ALGD and normal colorectal mucosa from 40 subjects. Bacterial sequenc

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Sasi, Minnu, Sandeep Kumar, Om Prakash, et al. "Evaluation of Sensory Properties and Short-Chain Fatty Acid Production in Fermented Soymilk on Addition of Fructooligosaccharides and Raffinose Family of Oligosaccharides." Fermentation 11, no. 4 (2025): 194. https://doi.org/10.3390/fermentation11040194.

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High potential is attributed to the concomitant use of probiotics and prebiotics in a single food product, called “synbiotics”, where the prebiotic component distinctly favours the growth and activity of probiotic microbes. This study implemented a detailed comparison between the prebiotic effect of Fructooligosaccharides (FOSs) and Raffinose family oligosaccharides (RFOs) on the viable count of bacteria, hydrolysis into monosaccharides, the biosynthesis of short-chain fatty acids and sensory attributes of soymilk fermented with 1% (v/v) co-cultures of Lacticaseibacillus rhamnosus JCM1136 and

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Gallage, Nethaji J., Kirsten JÃ¸rgensen, Christian Janfelt, et al. "The Intracellular Localization of the Vanillin Biosynthetic Machinery in Pods of Vanilla planifolia." Plant and Cell Physiology 59, no. 2 (2017): 304–18. http://dx.doi.org/10.1093/pcp/pcx185.

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44

Kundu, Anish. "Vanillin biosynthetic pathways in plants." Planta 245, no. 6 (2017): 1069–78. http://dx.doi.org/10.1007/s00425-017-2684-x.

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Jang, Siyoung, Minjeong Park, Do-Gyeong Lee, Jung-Hyun Lim, Ji-Won Jung, and Byoung-Cheorl Kang. "Breeding Capsicum chinense Lines with High Levels of Capsaicinoids and Capsinoids in the Fruit." Agriculture 11, no. 9 (2021): 819. http://dx.doi.org/10.3390/agriculture11090819.

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Capsaicinoids, which cause a hot sensation when eaten, are uniquely present in pepper (Capsicum sp.) and are biosynthesized by combining vanillyl amine with branched fatty acids. A mutation in the gene encoding putative aminotransferase (pAMT)—the enzyme that normally biosynthesizes the capsaicinoid precursor vanillyl amine—leads instead to the biosynthesis of vanillyl alcohol, which combines with branched fatty acids to form capsinoids. Here, we report a method for increasing the capsaicinoid and capsinoid contents using quantitative trait locus (QTL) alleles involved in capsaicinoid biosynth

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Mehari, Teame Gereziher, Jungfeng Tang, Haijing Gu, et al. "Insights into the Role of GhTAT2 Genes in Tyrosine Metabolism and Drought Stress Tolerance in Cotton." International Journal of Molecular Sciences 26, no. 3 (2025): 1355. https://doi.org/10.3390/ijms26031355.

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Gossypium hirsutum is a key fiber crop that is sensitive to environmental factors, particularly drought stress, which can reduce boll size, increase flower shedding, and impair photosynthesis. The aminotransferase (AT) gene is essential for abiotic stress tolerance. A total of 3 Gossypium species were analyzed via genome-wide analysis, and the results unveiled 103 genes in G. hirsutum, 47 in G. arboreum, and 53 in G. raimondii. Phylogenetic analysis, gene structure examination, motif analysis, subcellular localization prediction, and promoter analysis revealed that the GhAT genes can be classi

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Sadler, Joanna C., and Stephen Wallace. "Microbial synthesis of vanillin from waste poly(ethylene terephthalate)." Green Chemistry 23, no. 13 (2021): 4665–72. http://dx.doi.org/10.1039/d1gc00931a.

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Girawale, Savita D., Surya N. Meena, Vinod S. Nandre, Suresh B. Waghmode, and Kisan M. Kodam. "Biosynthesis of vanillic acid by Ochrobactrum anthropi and its applications." Bioorganic & Medicinal Chemistry 72 (October 2022): 117000. http://dx.doi.org/10.1016/j.bmc.2022.117000.

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Adiputra, I. Gede Ketut. "SUGAR BIOSYNTHESIS IN VANILLA PLANTS AND PHALAENOPSIS SEEDLINGS AFTER APPLICATION OF FERTILIZERS." Jurnal Biologi Udayana 21, no. 2 (2018): 43. http://dx.doi.org/10.24843/jbiounud.2017.vol21.i02.p01.

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In tropical country, vanilla encounters two main environmental conditions, wet and dry seasons. In the wet seasons when the amount of water available favours high growth rate, plants acquire more nutrients. However during dry seasons when water uptake via the root is limited and water loss from the shoot is increasing, vanilla will experience severe desiccations. In other cases, under condition of culture in bottle, phalaenopsis seedlings develop a very thin cuticle layers. These seedlings will experience a high rate of water loss when it is then transferred into ex vitro environmental conditi

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Petrulova, Veronika, Maria Vilkova, Zuzana Kovalikova, Matus Sajko, and Miroslav Repcak. "Ethylene Induction of Non-Enzymatic Metabolic Antioxidants in Matricaria chamomilla." Molecules 25, no. 23 (2020): 5720. http://dx.doi.org/10.3390/molecules25235720.

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Phytochemical investigations of Matricaria chamomilla L. (Asteraceae) stated the presence of several compounds with an established therapeutic and antioxidant potential. The chamomile non-enzymatic antioxidant system includes low molecular mass compounds, mainly polyphenols such as cinnamic, hydroxybenzoic and chlorogenic acids, flavonoids and coumarins. The objective of this work was to evaluate the role of the non-enzymatic antioxidant system after stimulation by ethylene in tetraploid chamomile plants. Seven days of ethylene treatment significantly increased the activity of phenylalanine am

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