Log in

Relevant bibliographies by topics / VAP proteins / Dissertations / Theses

To see the other types of publications on this topic, follow the link: VAP proteins.

Dissertations / Theses on the topic 'VAP proteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'VAP proteins.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Di, Mattia Thomas. "Identification et caractérisation de la protéine MOSPD2, un bâtisseur de sites de contact membranaire impliquant le réticulum endoplasmique." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ043.

Full text

Abstract:

Les sites de contact membranaire (SCM) sont des régions subcellulaires où deux organites sont physiquement connectés. Ces micro-domaines, moléculairement définis par des interactions protéine-protéine et/ou protéine-membrane, sont impliqués dans la dynamique des organites et la communication inter-organites. Le champ disciplinaire des SCM s’enrichit constamment grâce à la découverte de nouveaux acteurs moléculaires impliqués dans l'attachement des organites entre eux. Dans ce contexte de recherche, nous avons identifié un nouvel acteur impliqué dans la formation de SCM, appelé MOSPD2 (motile s

APA, Harvard, Vancouver, ISO, and other styles

2

Zhang, Wendy W. "The Role of ALS8-linked VAMP-associated Protein B (VAPB) in Caenorhabditis elegans Motor Neurons." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32242.

Full text

Abstract:

Amyotrophic Lateral Sclerosis (ALS) is a fatal, late-onset, progressive neurodegenerative disease. A familial form of ALS, autosomal dominant ALS8, is characterized by a mutation in an ER membrane protein, VAPB. To characterize the role of VAPB in motor neurons, two C. elegans models were generated: one expressing human VAPB-P56S and another with the knockdown of C. elegans VAPB ortholog, VPR-1. Overexpression of human VAPB in DA neurons caused backward locomotion defects, enhanced vulnerability to oxidative stress and premature neuronal death. Knockdown of vpr-1 in C. elegans recapitulated th

APA, Harvard, Vancouver, ISO, and other styles

3

Malhotra, Shikha. "B-cell-antigen receptor endocytosis uses a distinct signaling pathway, involving LAB, Vav, dynamin and Grb2." Oklahoma City : [s.n.], 2009.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

4

Jerkovic, Ante. "Proteomics of wheat bran (Triticum aestivum var. Babbler)." Australia : Macquarie University, 2006. http://hdl.handle.net/1959.14/43954.

Full text

Abstract:

Thesis (MSc (Hons))--Macquarie University, Division of Environmental & Life Sciences, Dept. of Chemistry & Biomolecular Sciences, 2006.<br>Bibliography: leaves 153-158.<br>Wheat is a major crop in Australia with around 25 million tonnes of grain harvested in an average year. Improved wheat grain cultivars and wheat grain milling can result in higher biological yields and flour quality. The introduction covers the general aspects of the wheat grain from bran development and structure through to millings and the importance of flour quality in flour-based products. It also highlights the problem

APA, Harvard, Vancouver, ISO, and other styles

5

Tickle, Joseph. "The role of vascular adhesion protein (VAP)-1 during inflammatory liver disease." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8217/.

Full text

Abstract:

Liver disease is the fifth largest killer in the United Kingdom and with the numbers of diagnoses increasing each year there is an urgent need for novel therapeutic interventions. This thesis examines one potential target, Vascular Adhesion Protein (VAP)-1: an amine oxidase enzyme with reported adhesin functionality. The results herein confirm a primarily sinusoidal localisation of VAP-1, expression of which was upregulated in the liver during chronic inflammation correlated with diminished enzyme activity. Functional analysis of sinusoidal VAP-1 in vitro did not demonstrate any effect of inhi

APA, Harvard, Vancouver, ISO, and other styles

6

Premsler, Thomas [Verfasser], Albert [Akademischer Betreuer] Sickmann, and Jan Georg [Gutachter] Hengstler. "Mass spectrometry based interaction study of the STIM1 and VASP proteins : (Massenspektrometrie-basierte Interaktionsstudie der Proteine STIM1 und VASP) / Thomas Premsler. Betreuer: Albert Sickmann. Gutachter: Jan Georg Hengstler." Dortmund : Universitätsbibliothek Dortmund, 2012. http://d-nb.info/1110892373/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Opitz, Robert [Verfasser]. "Inhibition von Protein-Protein-Wechselwirkungen : Peptidomimetika für VASP-EVH1 / Robert Opitz." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1035182467/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Mügschl, Monika. "Charakterisierung molekularer und genetischer Interaktionen von RasGAP in Drosophila melanogaster : Untersuchungen zur Neurodegenerationsmutante vap." kostenfrei, 2008. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1051/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Chen, X. "Ena/VASP proteins interact directly with the WAVE complex." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1332888/.

Full text

Abstract:

Ena/VASP proteins have emerged as key regulators of the actin cytoskeleton during cell migration. They are conserved from flies to mammals, where they consist of three family members: Mena, VASP and Evl. All three proteins localise to sites of cell adhesion and the leading edge of migrating cells, where they play an important role in regulating actin polymerization. Ena/VASP proteins consist of three domains, EVH1 and EVH2 domains, which are separated by a proline rich region. The EVH1 domain mediates the intra-cellular targeting of Ena/VASP proteins by interacting with FPPPP motifs found in p

APA, Harvard, Vancouver, ISO, and other styles

10

Zhang, Ben. "The role of VAMP proteins in K+ channel regulation." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6230/.

Full text

Abstract:

SNARE (soluble N-ethylmaleimide-sensitive factor protein attachment protein receptor) proteins drive vesicle traffic, delivering membrane and cargo to target sites within the cell and at its surface. They contribute to cell homeostasis, morphogenesis and pathogen defense. A subset of SNAREs, including the Arabidopsis SNARE SYP121, are known also to coordinate solute uptake via physical interactions with K+ channels and to moderate their gating at the plasma membrane. R-SNAREs, also known as vesicle-associated membrane proteins (VAMPs), are most commonly associated with trafficking vesicles. In

APA, Harvard, Vancouver, ISO, and other styles

11

Vesterlund, Katja, and Alexandra Adamovic. "Proteiner : En kvantitativ studie om individers kunskap och val av proteiner." Thesis, Luleå tekniska universitet, Institutionen för hälsovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-74932.

Full text

Abstract:

Vi påverkas av allt runt omkring oss vilket direkt eller indirekt styr våra beslut av matval. Tidigare studier indikerar vikten av en balanserad kosthållning med ett likvärdigt intag av animalisk och växtbaserad protein för en hälsofrämjande livshållning. Studiens syfte var att ta del av allmänhetens kunskap och val kring proteiner. En webbaserad enkätundersökning delades ut via sociala medier för ett bredare urval. Bland de 105 respondenterna fanns en överrepresentation inom åldrarna 18-32 år och majoriteten var högutbildade. De främsta skälen till deras val av proteiner var pris, smak och dj

APA, Harvard, Vancouver, ISO, and other styles

12

Trivedi, Palak. "An exploration of Vascular Adhesion Protein (VAP)-1 expression in Primary Sclerosing Cholangitis (PSC)." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6569/.

Full text

Abstract:

Primary sclerosing cholangitis (PSC) is an immune-mediated cholangiopathy and extra-intestinal manifestation of inflammatory bowel disease (IBD). It is hypothesised that long-lived, α4β7\(^+\) CCR9\(^+\) effector memory T-cells generated within the intestine drive hepatobiliary injury in PSC, being recruited to the liver via hepatic endothelial expression of mucosal addressin cell adhesion molecule (MAdCAM)-1 and CCL25. Previous studies (mainly murine) claim CCL25 expression and CCR9\(^+\) T-cells as confined to small bowel under homeostatic and inflammatory conditions, whereas PSC is typified

APA, Harvard, Vancouver, ISO, and other styles

13

Mir, Ali N. "Protein improvement in Triticum turgidum var. durum (Desf.) by induced mutations and hybridization with Triticum turgidum var. diccoides (Korn.)." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377457.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

van, Beijeren Peter [Verfasser]. "Membrane Adsorption for the Capturing of Proteins / Peter van Beijeren." München : Verlag Dr. Hut, 2012. http://d-nb.info/102939931X/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Scott, Jeanie Anne. "The role of Ena/VASP proteins in cadherin-based adhesion /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18771.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Bhavsar, Parag Jayprakash. "The role of Vav proteins in macrophage morphology and migration." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444025/.

Full text

Abstract:

The Rho family GTPases are key signalling components that regulate the cytoskeleton and adhesion during cell migration. The Vav family of proteins act as guanine nucleotide exchange factors for several Rho GTPases. There are three isoforms of Vav expressed in mammalian cells: Vav1, the expression of which is largely restricted to haematopoietic cells, Vav2 and Vav3. In this study the role of Vav proteins in macrophage migration has been investigated using macrophages derived from mice lacking one or all three Vav isoforms. Cell migration and morphology were not significantly affected when sing

APA, Harvard, Vancouver, ISO, and other styles

17

Clayton, E. "The role of p110δ and Vav proteins in BCR signalling". Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597761.

Full text

Abstract:

B-lymphocytes participate in the generation of effective immune responses capable of specifically recognising and selectively eliminating foreign microorganisms and molecules. The binding of an antigen to receptors on B cells activates signalling cascades that induce B cell proliferation, differentiation into memory and antibody secreting plasma cells that facilitate elimination of the antigen. PI3K and Vav are activated downstream of B cell receptor (BCR) and the CD19 co-receptor, p110δ isoform of catalytic subunit of PI3Kinase was chosen as a candidate for immunological assessment as its exp

APA, Harvard, Vancouver, ISO, and other styles

18

Adusei-Danso, Felix. "Systematic approach to protein crystallization :emphasis on Vaccinia virus complement control protein (VCP)." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4781_1188474852.

Full text

Abstract:

<p>This work examined the systematic approach to protein crystallization, exploring some of the techniques that have been developed to enhance the success rate of crystallization. The work was centered on two proteins<br>namely Vaccinia virus complement control protein (VCP) and glutamate dehydrogenase (GDH) from Bacteriodes fragilis. The crystal structures of the full lengthe native VCP and VCP bound to heparin had already been determined. In the same way, the structure of GDH from Bacteriodes fragilis is not known, even though structures of other GDHs from different organisms have been deter

APA, Harvard, Vancouver, ISO, and other styles

19

Ghanim, Mustafa. "Les aspects génétiques des démences frontotemporales." Paris 6, 2010. http://www.theses.fr/2010PA066039.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Armiento, Aurora. "Inverse problems and data assimilation methods applied on protein polymerisation." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC022/document.

Full text

Abstract:

Cette thèse a pour objectif la mise en place d'une stratégie mathématique pour l'étude du processus physique de l'agrégation des protéines. L'étude de ce processus largement inconnu est particulièrement importante puisqu'il a été identifiée comme un élément clé d'une vaste gamme de maladies incurables, appelées maladies amyloïdes. Les maladies à prions appartiennent à cette classe et sont causées par l'agrégation d'une configuration mal pliée de la protéine prion. Notre travail contribue à la recherche sur les maladies à prions, en se concentrant sur deux types d'agrégats : les oligomères et l

APA, Harvard, Vancouver, ISO, and other styles

21

Baumann, Claudia. "Erzeugung und Charakterisierung von Knockout-Mäusen des Maus-Vas-Deferens- Proteins." [S.l. : s.n.], 2004. http://www.diss.fu-berlin.de/2004/135/index.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Menzies, Annabelle Sheila 1972. "Ena/VASP proteins regulate vertebrate nervous system development : a thesis presented." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28675.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.<br>Includes bibliographical references.<br>Nervous system development is a complex morphogenetic process. Cell migration, axon guidance and many other regulated cell shape changes build a functional nervous system. These processes depend upon regulation of the actin cytoskeleton. Ena/VASP proteins are able to remodel the actin cytoskeleton in response to extracellular signals and have been shown to regulate the motility and morphology of a variety of cells. I have investigated the in vivo requirement for the verteb

APA, Harvard, Vancouver, ISO, and other styles

23

Watkins, Jason Derrick. "X-ray structures of P22 c2 repressor-DNA complexes the mechansism of direct and indirect readout /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26709.

Full text

Abstract:

Thesis (Ph.D)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.<br>Committee Chair: Loren D. Williams; Committee Member: Donald Doyle; Committee Member: Nicholas V. Hud; Committee Member: Roger Wartell; Committee Member: Stephen Harvey. Part of the SMARTech Electronic Thesis and Dissertation Collection.

APA, Harvard, Vancouver, ISO, and other styles

24

Fox, Helen Mary. "Toca-1 driven actin polymerisation at membranes." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275610.

Full text

Abstract:

Regulation of the actin cytoskeleton is key to cellular function and underlies processes including cell migration, mitosis and endocytosis. Motile cells send out dynamic actin protrusions that enable them to sense and interact with their environment, as well as generating physical forces. Linking of the actin cytoskeleton to the cell membrane is essential for the formation of these protrusions. The proteins that are thought to fulfil such a role have a membrane interacting domain (such as the PH domain in lamellipodin, or I-BAR protein in IRSp53) and a domain which interacts with actin regulat

APA, Harvard, Vancouver, ISO, and other styles

25

Kwiatkowski, Adam Vincent 1974. "Characterization of Tuba, a novel Ena/VASP ligand, and function of Ena/VASP proteins in mouse development." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28936.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, February 2005.<br>Includes bibliographical references.<br>Regulated actin assembly drives cells movement, adhesion and shape change. The EnaNASP family of proteins controls actin filament elongation and are important regulators of axon guidance and cell motility. In vertebrates, the family consists of Mena (Mammalian Enabled), VASP (Vasodilator Stimulated Phosphoprotein), and EVL (Ena-VASP-Like). This thesis work focused on understanding the vertebrate EnaNASP protein family by discovering pathways that regulate EnaNASP

APA, Harvard, Vancouver, ISO, and other styles

26

Häggblom, Jenny. "Ämnesfördjupning proteintillskott och dess konsekvenser : Är proteintillskott att förespråka, vad rekommenderas och när?" Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-25362.

Full text

Abstract:

I dagens samhälle finns en stor marknad för proteintillskott. Kosttillskottsföretagen gör stora pengar för att atleter tror sig dra nytta av tillskotten och pulvren. Är proteintillskott i form av vassle, kasein, soja och kreatin att föredra eller är det vanlig kost som är bäst för att bygga muskler i samband med träning? Syftet med denna ämnesfördjupning är att fokusera på proteiner som näringsämne samt som ett tillskott får både erfarna och icke-erfarna styrkeidrottare samt en jämförelse mellan olika typer av proteintillskott. Ämnesfördjupningen försöker också att svara på vilket tillskott so

APA, Harvard, Vancouver, ISO, and other styles

27

Breitsprecher, Dennis [Verfasser]. "Molecular mechanism of actin filament elongation by Ena/VASP proteins / Dennis Breitsprecher." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover, 2010. http://d-nb.info/1008374679/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Deshmukh, Mandar Vinayakrao. "NMR investigations on structure, dynamics and function of VAT-N and DOTATOC." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972317864.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Leroux, Florence. "Etude in vitro d'inhibiteurs de tyrosine kinases et de phosphodiesterases et d'un analogue du vasoactive intestinal peptide potentiellement actifs dans l'asthme." Lille 2, 1996. http://www.theses.fr/1996LIL2P253.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Jang, HyeIn. "FUNCTIONAL CHARACTERIZATION OF SCAFFOLD PROTEIN SHOC2." UKnowledge, 2018. https://uknowledge.uky.edu/biochem_etds/39.

Full text

Abstract:

Signaling scaffolds are critical for the correct spatial organization of enzymes within the ERK1/2 signaling pathway and proper transmission of intracellular information. However, mechanisms that control molecular dynamics within scaffolding complexes, as well as biological activities regulated by the specific assemblies, remain unclear. The scaffold protein Shoc2 is critical for transmission of the ERK1/2 pathway signals. Shoc2 accelerates ERK1/2 signaling by integrating Ras and RAF-1 enzymes into a multi-protein complex. Germ-line mutations in shoc2 cause Noonan-like RASopathy, a disorder wi

APA, Harvard, Vancouver, ISO, and other styles

31

Nozaki, Shohei. "Architecture of the BBSome and its role in ciliary protein trafficking." Kyoto University, 2019. http://hdl.handle.net/2433/242664.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Van, Veen John Edward. "Repulsive axonal pathfinding requires the Ena/VASP family of actin regulatory proteins in vertebrates." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/73777.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Vertebrate nervous system development requires the careful interpretation of many attractive and repulsive guidance molecules. For the incredibly complicated wiring diagram comprising the vertebrate nervous system to elaborate properly, the highly motile "growth cone" at the tip of an axon must sense extracellular embryonic cues and respond through a number of intracellular interactions leading ultimately to coordinated changes in c

APA, Harvard, Vancouver, ISO, and other styles

33

Burger, Willem Jacobus. "Die verbetering van die benutting van laegraadse ruvoer vir wol- en vleisproduksie deur aanvulling van beskermde proteienbronne en/of aminosure." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52798.

Full text

Abstract:

Thesis (MScAgric) -- University of Stellenbosch, 2002.<br>ENGLISH ABSTRACT: Low quality roughage is often used in the Western Cape as the only source of roughage for the young growing ruminant. Production levels of these animals is unsatisfactory and therefore supplementation is required. It is necessary when small grains are fed to also include protein sources in the diets. For high production, these protein sources must also be protected against rumen degradation. Good results are reported with the treatment of sunflower oilcakemeal (SFOCM) with formaldehyde (0.86 g formaldehyde per 10

APA, Harvard, Vancouver, ISO, and other styles

34

Zhu, Kaiyuan, and 祝开元. "Polo-like kinase 1 (Plk1) phosphorylates VCP T76 during mitosis for the fragmentation of Golgi in mammalian cell." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Silbernagel, Nicole [Verfasser], and Niels [Akademischer Betreuer] Decher. "VAP-Proteine sind wesentliche Bestandteile nativer HCN2-Kanalkomplexe und regulieren die Funktion deskardialen If -Schrittmacherstroms / Nicole Silbernagel ; Betreuer: Niels Decher." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1140834959/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Prathapa, Siriyara Jagannatha [Verfasser], and Sander van [Akademischer Betreuer] Smaalen. "Dynamic charge densities of amino acids and proteins / Prathapa Siriyara Jagannatha. Betreuer: Sander van Smaalen." Bayreuth : Universität Bayreuth, 2013. http://d-nb.info/1059353083/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

TAUBENBLATT, PATRICE. "Tri intracellulaire de la vamp et etude de la proteine moteur kif 1a." Paris 11, 2001. http://www.theses.fr/2001PA112142.

Full text

Abstract:

La vamp 2 est une proteine de la vesicule synaptique essentielle au phenomene d'exocytose. La formation d'un complexe entre la vamp et 2 proteines de la membrane presynaptique (syntaxine et snap 25) va permettre la fusion entre ces 2 structures membranaires et la liberation du neurotransmetteur. Dans un premier temps, nous nous sommes interesses a la localisation subcellulaire de la vamp a la terminaison nerveuse. Grace a une technique de marquages apres cryofracture, nous montrons que la vamp est associee a la membrane presynaptique. Ces resultats suggerent qu'en plus d'une localisation vesic

APA, Harvard, Vancouver, ISO, and other styles

38

Clairmont, François. "Structure of the insecticidal crystal protein from Bacillus thuringiensis var. kurstaki HD-73." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/NQ48094.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Offner, Kristin [Verfasser], and Kai [Gutachter] Schuh. "SH3-mediated protein interactions of Mena and VASP / Kristin Offner ; Gutachter: Kai Schuh." Würzburg : Universität Würzburg, 2017. http://d-nb.info/1144862493/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Abraham, Sonny T. "Denervation Supersensitivity of the Rat Vas Deferens: A Role for Protein Kinase C." Digital Commons @ East Tennessee State University, 1994. https://dc.etsu.edu/etd/2622.

Full text

Abstract:

A role for protein kinase C (PKC) in the denervation-induced supersensitivity of the rat vas deferens was investigated. Chronic, surgical denervation of the rat vas deferens (up to 8 days) resulted in tissues that produced enhanced contractile responses to norepinephrine (NE) in isolated organ baths. Single challenges of NE (10 $\mu$M) produced 0.6 $\pm$ 0.1 g of maximal tension in the control vas whereas in the paired, denervated tissue 2.2 $\pm$ 0.3 g of tension was recorded (n = 6). Cumulative concentration-effect curves to NE produced in the denervated vas deferens were shifted 18-fold to

APA, Harvard, Vancouver, ISO, and other styles

41

Budnik-Zawilska, Milka. "Characterising the role of Valosin Containing Protein (VCP) in autophagy and cell differentiation." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/58434/.

Full text

Abstract:

Valosin containing protein (VCP)/p97 is a hexameric ATPase of the AAA family, which regulates a wide array of essential cellular processes. Dominant mutations in the N-domain of the VCP give rise to the complex disease syndrome known as Inclusion body myopathy with Paget disease of the bone and frontotemporal dementia (IBMPFD). VCP plays a key role in the ubiquitin-proteasome dependent protein degradation although mutations in VCP seem to result in a late stage autophagy defect. Osteoclast precursors containing VCP mutations are hyper-responsive to RANKL and M-CSF treatment. This suggests that

APA, Harvard, Vancouver, ISO, and other styles

42

Parry, Katherine Elizabeth. "Investigation of the interactions of DVAP-33A, the orthologue of human VAPB." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5538.

Full text

Abstract:

Amyotrophic Lateral Sclerosis is the most common type of motor neuron disease, characterized by progressive degeneration of the upper and lower motor neurons. Sufferers present with symptoms of muscle weakness and this quickly develops on to paralysis and finally death due to respiratory failure within 5 years of disease onset. Although the majority of cases are sporadic, about 10% are familial and it is hoped that through the investigation of these few cases a greater understanding of the disease process, the reasons for its delayed onset and vulnerability of motor neurons will be achieved. R

APA, Harvard, Vancouver, ISO, and other styles

43

Schulze, Andrea. "A role for the ubiquitin domain protein HERP in ER-associated protein degradation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15575.

Full text

Abstract:

Die ER-assoziierte Proteindegradation (ERAD) ist Teil des Qualitätskontrollsystems am ER, um der Akkumulation von fehlgefalteten Proteinen im ER entgegenzuwirken. Hierbei werden ERAD-Substrate mit Hilfe von E3-Ligasen wie z.B. HRD1 ubiquityliert und anschließend durch den p97-Ufd1-Npl4 Komplex aus der ER-Membran extrahiert. Im Zytosol werden diese extrahierten Proteine vom 26S Proteasom abgebaut. Für die Retrotranslokation von ERAD- Substraten werden zudem die Membranproteine Derlin-1 und VIMP benötigt, welche mit p97 assoziieren und einen Proteinkomplex bilden. HERP ist ein ER-lo

APA, Harvard, Vancouver, ISO, and other styles

44

Mebane, Leslie Marie. "The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65293.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>During central nervous system development cortical neurons extend a primary axon and multiple collateral branches to connect to numerous synaptic targets. While many guidance cues and their receptors have well-characterized roles in cortical axon guidance, the pathways that link these signals to cytoskeletal remodeling remain poorly understood. The Ena/VASP family of proteins function as key signaling molecules that influences actin

APA, Harvard, Vancouver, ISO, and other styles

45

van, Dijck Phillip [Verfasser]. "Die Rolle von inaktivem Rhomboid-Protein 2 (iRhom2) im akuten Myokardinfarkt / Phillip van Dijck." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1241540004/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Darbyson, Angie L. "ORP-3 Rescues ER Membrane Expansions Caused by the VAPB-P56S Mutation in Familial ALS." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/29054.

Full text

Abstract:

A mutation in ER membrane protein VAPB is responsible for causing a familial form of ALS (ALS8). The VAPB-P56S mutation causes protein aggregation and a nuclear envelope defect, where retrograde transport is disrupted. Over-expression of a FFAT peptide from OSBP1 reduces the size of VAPB-P56S aggregates and restores retrograde transport. A screen was performed on FFAT-motif containing ORPs to determine if any could rescue the mutant phenotype. ORP3 successfully reduced aggregate size and restored transport to the nuclear envelope. ER membrane protein Sac1, a PI4P phosphatase cycles between

APA, Harvard, Vancouver, ISO, and other styles

47

REVIRON, MARIE-PIERRE. "Caracterisation d'une proteine induite par la contrainte hydrique chez brassica napus var. Oleifera l. (colza)." Paris 6, 1991. http://www.theses.fr/1991PA066618.

Full text

Abstract:

Le colza presente des adaptations morphologiques et physiologiques a la secheresse. L'analyse des profils proteiques par electrophorese bidimensionnelle (ebd) a revele une quarantaine de variations proteiques dans les feuilles jeunes de plantes soumises a la secheresse, reversibles apres rehydratation. Parmi elles, un doublet de polypeptides de 22 kda et de points isoelectriques d'environ 5. 1, a ete etudie et nomme bnd22. Il n'a pas ete detecte dans les plantes arrosees, s'accumule fortement sous contrainte hydrique (secheresse, choc hydrique, traitement par le nacl), mais pas sous choc therm

APA, Harvard, Vancouver, ISO, and other styles

48

Taragnat, Catherine. "Mise en evidence, androgenodependance et ontogenese d'une proteine majeure de 34 kd specifique du canal deferent de souris." Clermont-Ferrand 2, 1988. http://www.theses.fr/1988CLF21093.

Full text

Abstract:

Mise en evidence d'une proteine majeure de 34,5 kd par methode electrophoretiques dans le canal deferent chez la souris. Proteine basique appelee mvdp (mouse vas deferens protein), glycosylee (presence de fucose) represente 17 % des proteines solubles de l'homogenese et 42 % du fluide deferentiel. Cette proteine possede une specificite tissulaire revelee par les anticorps poly- et monoclonaux diriges contre elle. Hors de l'ontogenese, cette proteine n'apparait qu'au 20**(eme) jour de vie postnatale et augmente ensuite de concert avec les androgenes circulants et deferentiels. Des experience de

APA, Harvard, Vancouver, ISO, and other styles

49

Hill, Jakob, and Olle Segestam. "Vad smakar Peaso? : Ett sensoriskt konsumenttest på Peaso med 4 och 8 veckorfermenteringstid." Thesis, Örebro universitet, Restaurang- och hotellhögskolan, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94068.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Viviers, Swys Francois. "Effect of dietary energy and protein on the production parameters of slaughter ostriches (Struthio camelus var. domesticus)." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/98065.

Full text

Abstract:

Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: When modern man assumed the responsibility of domesticating animals for his own purposes, he directly accepted the responsibility associated with feeding and caring for them. Considering intensive production systems, nutrition is one of the most important aspects in maintaining healthy livestock as well as ensuring profitability is achieved. This is due to the fact that the feeding of the livestock is often the most expensive overhead cost encountered. In ostrich production systems, nutrition costs total an estimated 70 – 80% of

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!