Relevant bibliographies by topics / Variable number of tandem repeats

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
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  5. Conference papers

Academic literature on the topic 'Variable number of tandem repeats'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 February 2022

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Journal articles on the topic "Variable number of tandem repeats"

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Kim, Song, Ha, et al. "Variable Number Tandem Repeats in the Mitochondrial DNA of Lentinula edodes." Genes 10, no. 7 (2019): 542. http://dx.doi.org/10.3390/genes10070542.

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Variable number tandem repeats (VNTRs) in mitochondrial DNA (mtDNA) of Lentinula edodes are of interest for their role in mtDNA variation and their application as genetic marker. Sequence analysis of three L. edodes mtDNAs revealed the presence of VNTRs of two categories. Type I VNTRs consist of two types of repeat units in a symmetric distribution, whereas Type II VNTRs contain tandemly arrayed repeats of 7- or 17-bp DNA sequences. The number of repeat units was variable depending on the mtDNA of different strains. Using the variations in VNTRs as a mitochondrial marker and the A mating type as a nuclear type marker, we demonstrated that one of the two nuclei in the donor dikaryon preferentially enters into the monokaryotic cytoplasm to establish a new dikaryon which still retains the mitochondria of the monokaryon in the individual mating. Interestingly, we found 6 VNTRs with newly added repeat units from the 22 mates, indicating that elongation of VNTRs occurs during replication of mtDNA. This, together with comparative analysis of the repeating pattern, enables us to propose a mechanistic model that explains the elongation of Type I VNTRs through reciprocal incorporation of basic repeat units, 5’-TCCCTTTAGGG-3’ and its complementary sequence (5’-CCCTAAAGGGA-3’).
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Huang, Ying, Xin Huang, Xuming Zhou, et al. "Immune activation by a multigene family of lectins with variable tandem repeats in oriental river prawn ( Macrobrachium nipponense )." Open Biology 10, no. 9 (2020): 200141. http://dx.doi.org/10.1098/rsob.200141.

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Genomic regions with repeated sequences are unstable and prone to rapid DNA diversification. However, the role of tandem repeats within the coding region is not fully characterized. Here, we have identified a new hypervariable C-type lectin gene family with different numbers of tandem repeats (Rlecs; R means repeat) in oriental river prawn ( Macrobrachium nipponense ) . Two types of repeat units (33 or 30 bp) are identified in the second exon, and the number of repeat units vary from 1 to 9. Rlecs can be classified into 15 types through phylogenetic analysis. The amino acid sequences in the same type of Rlec are highly conservative outside the repeat regions. The main differences among the Rlec types are evident in exon 5. A variable number of tandem repeats in Rlecs may be produced by slip mispairing during gene replication. Alternative splicing contributes to the multiplicity of forms in this lectin gene family, and different types of Rlecs vary in terms of tissue distribution, expression quantity and response to bacterial challenge. These variations suggest that Rlecs have functional diversity. The results of experiments on sugar binding, microbial inhibition and clearance, regulation of antimicrobial peptide gene expression and prophenoloxidase activation indicate that the function of Rlecs with the motif of YRSKDD in innate immunity is enhanced when the number of tandem repeats increases. Our results suggest that Rlecs undergo gene expansion through gene duplication and alternative splicing, which ultimately leads to functional diversity.
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Bakhtiari, Mehrdad, Sharona Shleizer-Burko, Melissa Gymrek, Vikas Bansal, and Vineet Bafna. "Targeted genotyping of variable number tandem repeats with adVNTR." Genome Research 28, no. 11 (2018): 1709–19. http://dx.doi.org/10.1101/gr.235119.118.

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Ghosh, Raikamal, G. Balakrish Nair, Li Tang, et al. "Epidemiological study ofVibrio choleraeusing variable number of tandem repeats." FEMS Microbiology Letters 288, no. 2 (2008): 196–201. http://dx.doi.org/10.1111/j.1574-6968.2008.01352.x.

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Danandeh, Mostafa, Seyed Reza Moadab, Mohammad Asgharzadeh, Naser Alizadeh, and Reza Ghotaslou. "Mycobacterium tuberculosis Diversity by Exact Tandem Repeats-Variable Number Tandem Repeat Method in Azerbaijan, Iran." Infectious Diseases in Clinical Practice 26, no. 2 (2018): 80–83. http://dx.doi.org/10.1097/ipc.0000000000000561.

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Subirana, Juan A., and Xavier Messeguer. "Tandem Repeats in Bacillus: Unique Features and Taxonomic Distribution." International Journal of Molecular Sciences 22, no. 10 (2021): 5373. http://dx.doi.org/10.3390/ijms22105373.

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Little is known about DNA tandem repeats across prokaryotes. We have recently described an enigmatic group of tandem repeats in bacterial genomes with a constant repeat size but variable sequence. These findings strongly suggest that tandem repeat size in some bacteria is under strong selective constraints. Here, we extend these studies and describe tandem repeats in a large set of Bacillus. Some species have very few repeats, while other species have a large number. Most tandem repeats have repeats with a constant size (either 52 or 20–21 nt), but a variable sequence. We characterize in detail these intriguing tandem repeats. Individual species have several families of tandem repeats with the same repeat length and different sequence. This result is in strong contrast with eukaryotes, where tandem repeats of many sizes are found in any species. We discuss the possibility that they are transcribed as small RNA molecules. They may also be involved in the stabilization of the nucleoid through interaction with proteins. We also show that the distribution of tandem repeats in different species has a taxonomic significance. The data we present for all tandem repeats and their families in these bacterial species will be useful for further genomic studies.
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Broza, Yoav Y., Yael Danin-Poleg, Larisa Lerner, Lea Valinsky, Meir Broza, and Yechezkel Kashi. "Epidemiologic Study ofVibrio vulnificusInfections by Using Variable Number Tandem Repeats." Emerging Infectious Diseases 15, no. 8 (2009): 1282–85. http://dx.doi.org/10.3201/eid1508.080839.

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Porrini, S. Costanzi, A. Sciarra, N. Sulli, M. Piane, R. Gualtieri, and G. Del Porto. "Variable Number of Tandem Repeats in Zygosity Diagnosis in Twins." Acta geneticae medicae et gemellologiae: twin research 39, no. 4 (1990): 473–77. http://dx.doi.org/10.1017/s000156600000369x.

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AbstractThe use of DNA restriction fragment length polymorphisms (RFLP) to analyze variable number of tandem repeat (VNTR) sequences dispersed in the human genome, has become a powerful tool for the study of population genetics due to the very substantial polymorphism involved. Because the markers usually employed for twin zygosity determination (such as sex combination, placentation, HLA typing, blood group antigens, etc) may not be uniformly informative, we propose the use of synthetic olygonucleotides, representing VNTR “core” sequences, for the determination of zygosity in twins.
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Monot, M., N. Honore, C. Baliere, et al. "Are Variable-Number Tandem Repeats Appropriate for Genotyping Mycobacterium leprae?" Journal of Clinical Microbiology 46, no. 7 (2008): 2291–97. http://dx.doi.org/10.1128/jcm.00239-08.

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Urbančič, Dunja, Alenka Šmid, Gabriele Stocco, Giuliana Decorti, Irena Mlinarič-Raščan, and Nataša Karas Kuželički. "Novel motif of variable number of tandem repeats in TPMT promoter region and evolutionary association of variable number of tandem repeats with TPMT*3 alleles." Pharmacogenomics 19, no. 17 (2018): 1311–22. http://dx.doi.org/10.2217/pgs-2018-0123.

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Dissertations / Theses on the topic "Variable number of tandem repeats"

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SaidQasem, Osama. "Temporal and spatial explorations of Clostridium difficile variable number tandem repeats." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211224.

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Clostridium difficile infection (CDI) has recently emerged as a major health problem. An understanding of the micro-epidemiology of the infection is decisive for the design and implementation of control polices. Presently, typing using PCR ribotyping (RT), Multi-locus Sequence Typing (MLST) and Multi-locus Variable Number Tandem Repeat Analysis (MLVA) can be used to investigate recent transmission events of C. difficile. In the case of MLVA, different criteria have been used to classify strains and this reflects inconsistencies in the contemporary knowledge of change in MLVA polymorphisms. In this study, temporal and spatial investigations were conducted to better understand the dynamics of change in C. difficile VNTR loci. The 164 isolates from the collection yielded 25 different STs, with ST161 and ST171 being newly described. The congruence of MLST to the other typing methods of RT and tcdC, strengthens the robustness of discrimination of these methods. Sub-typing using MLVA, however yielded 139 strains, and again there was congruence to the aforementioned methods. Clustering of MLVA strains into groups revealed Single and Multi-Isolate Strains linked together as single locus variants with groups coordinating with MLST types within ST1 and ST3. The lowest MLVA diversity was seen in the Period of Increased Incidence and was primarily responsible for high incidence rates. These groups of MLVA related isolates were used to characterise the instability of the repeat sequences of MLVA loci. 2 Locus differences were examined from the perspective of the genetic role of the locus, DNA polymerase amplification, the impact of different growth conditions on the fitness of the repeat sequences and of the frequency of repeat changes in the natural population. These studies have focused on the on the drivers of change of VNTR loci in general and will allow a more rational approach to using MLVA loci in epidemiological studies.
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Manca, Maurizio. "Role of Variable Number Tandem Repeats (VNTRs) on gene expression in the CNS." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3007520/.

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It is now known that at least 80% of the human genome is composed of non-coding DNA which has a biochemical activity and is involved in a wide range of activities and mechanisms. Among these, epigenetic modifications, cis-trans gene expression regulation, transcription factor binding sequences, are the most studied. Non-coding DNA is often characterised by a polymorphic and repetitive nature and it is composed of a high density of GC nucleotides. These polymorphic and repetitive regions within the population may represent either protective elements or risk factors, based on population studies in various diseases, for several conditions and at the same time have the power to shape our behaviours or wellbeing. The compositions of transcription factor binding sites (BSs) and epigenetic factors at these regions act in concert with external and environmental factors to modify gene function and gene expression. This combined effect of environmental and genetic factors capable of influence people's wellbeing or disease risk is known as Gene - Environment Interaction (GxE) and it is a key feature that allows us to adapt to our surrounding. The data presented in this thesis will try to address some of the well characterised polymorphic variants associated with Central Nervous System (CNS) conditions, such as the Monoamine oxidase A (MAOA) gene, and I will show how they can modify gene expression in response to environmental stimuli. We also report two regulatory regions in the CACNA1C (Calcium Voltage-Gated Channel Subunit Alpha1 C) gene, strongly associated to schizophrenia by GWAS (Genome-Wide Association Study) investigations. Finally I will also report a novel polymorphic microsatellite in the promoter region of the gene that has been defined 'the master regulator' of transcription, the RE1-Silencing Transcription factor (REST) gene, that strongly suggests an association with Alzheimer's disease. Therefore I demonstrate a similarity in mechanisms and in the activity of these repeat elements in the promoter regions of three key genes for CNS behaviour and illustrate the potential power of these elements as transcriptional regulatory DNA regions.
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Kunorozva, Lovemore. "PERIOD3 variable number tandem repeat genotype associations with performance, injury, illness and re-entrainment." Doctoral thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22812.

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Background: Circadian rhythms are internally driven biological variations that fluctuate with a period of approximately 24 hours, even in the absence of external environmental time cues. These rhythms enable organisms to synchronise their internal clock time with external environmental time. This ensures appropriate timing of biological and metabolic processes, and allows anticipation of daily changes in the environment. Circadian rhythms also play an important role in sports in terms of optimising performance time-of-day and aiding adjustment to global time zone changes. Thus, performance, which is under the control of the athlete, may be impacted by event time-of-day scheduling in the new time zone. It has previously been shown that individual sport athletes in South Africa tend to be morning-types and carry the PERIOD3 (PER3) Variable Number Tandem Repeat (VNTR) 5-repeat allele, which has been associated with a preference for mornings. The distribution of the PER3 VNTR polymorphism in combination with an individual's preference for mornings or evenings has not yet been described in team sports. Differences in the PER3 VNTR genotype between team and individual sport athletes are expected, given that individual sport athletes may be free to choose the time-of-day at which they train. In contrast, team sport athletes usually train in groups, thus these individuals may not have the flexibility to choose their preferred training times. There are notable inter-individual differences in adjustment to jet-lag after time zone changes. A possible genetic candidate that may be responsible for some of this variation is the PER3 VNTR gene. This gene consist of two alleles corresponding in size to 4-repeats (PER34) or 5-repeats (PER35). Individuals are either homozygous for the 4-repeat allele (PER⁴⁄⁴) or the 5-repeat allele (PER3⁵⁄⁵), while others are heterozygous for the PER3 gene (PER34/5). The PER3 VNTR genotype might explain individual sensitivity to bright light and has been reported to be associated with sleep pressure- an increase in the brain's pressure and need for sleep, following an extended period of awakening. Individuals homozygous for the longer variant of the gene (i.e. PER3⁵⁄⁵) experience a higher sleep pressure during extended wakefulness. The PER3⁵⁄⁵ genotype has been reported to be more sensitive to the alerting and melatonin suppression effects of blue enriched light than the PER⁴⁄⁴ genotype. Aims: Therefore, the aim of Study 1 was to compare the chronotype and PER3 VNTR genotype distribution of South African Super Rugby players to individuals of low physical activity (i.e. those who are physically active ≤2 times per week). The aim of Study 2 was to determine whether PER3 VNTR genotype might contribute to inter-individual variation in the extent to which game involvement and quality of play are affected following trans-meridian travel. Further, the aim of Study 3 was to compare the impact of time zone travel during the 2012 Super Rugby competition in South African players genotyped as PER⁴⁄⁴, PER34/5 and PER3⁵⁄⁵ on the incidence of illnesses and injuries. Lastly, the aim of Study 4 was to compare the extent to which individuals genotyped as PER⁴⁄⁴ or PER3⁵⁄⁵ respond to appropriately-timed blue light exposure in order to resynchronise their circadian rhythm, following simulated eastward travel, based on changes in dim-light melatonin onset and cortisol circadian phases.
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Schlaphoff, Theresa Elizabeth-Anne. "A study to evaluate variable number of tandem repeat DNA polymorphisms in disputed paternity testing." Thesis, Cape Technikon, 1993. http://hdl.handle.net/20.500.11838/1465.

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Thesis (MDip (Medical Technology))--Cape Technikon, 1993<br>The use of genetic marker testing to resolve cases of disputed paternity, is well established. The number and range of systems used depends on the expertise of the laboratory, and for this reason various laboratories offer different systems. Standard testing includes tests in the following genetic marker systems: human leukocyte antigen (tissue) typing; red cell blood groups; and red cell enzyme and serum protein testing. The Provincial Laboratory for Tissue Immunology currently offers a range of 16 genetic marker systems capable of excluding >99% of falsely accused men. Following the discovery DNA polymorphisms, particularly VNTR DNA polymorphisms, and the commercial availability of VNTR DNA probes, PLTI decided to offer this service to our clients. This study was the initial phase in the establishment of a VNTR DNA typing laboratory and covered the determination of inter-and intra-gel accuracy and precision, selection of restriction enzyme/probe combination, and evaluation and comparison of the results of 100 disputed paternity cases tested using both standard and VNTR DNA typing. Of the 100 cases tested, in 33 cases, the putative father was excluded using standard testing. These exclusions were confirmed using VNTR DNA typing, and, furthermore, an additional two exclusions of paternity were shown using only VNTR DNA typing. In another two cases of disputed paternity, the exclusions obtained using standard tests required further confirmation. VNTR DNA typing convincingly excluded both falsely accused putative fathers. The VNTR DNA typing laboratory now functions as an integral part of the disputed paternity service. Due to the cost and time involved in VNTR DNA typing it is reserved at this stage for: those cases which require further confirmation of the results of standard testing; when the probability of paternity is low (<99.7%); or when a specific request is made.
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Ng, Sau-wah, and 吳秀華. "Population genetics study on the variable number of Tandem repeats (VNTR) loci of a Han Chinese population in Hong Kong and itsapplication in human identity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31224994.

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Weipert, Christine [Verfasser]. "Die Heterozygotie des Längenpolymorphismus "variable number of tandem repeats" des thrombozytären Glykoproteins Iba alpha als Risikofaktor für koronare Herzkrankheit und Myokardinfarkt in Niedrigrisikogruppen / Christine Weipert." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068591617/34.

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Box, Matthew. "Multiple-locus variable-number tandem-repeat analysis (MLVA) for clonal characterization of methicillin resistant Staphylococcus aureus strains." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2006. https://www.mhsl.uab.edu/dt/2008r/box.pdf.

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Radtke, Andreas. "Molecular Methods for Typing of Streptococcus agalactiae with Special Emphasis on the Development and Validation of a Multi-Locus Variable Number of Tandem Repeats Assay (MLVA)." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for laboratoriemedisin, barne- og kvinnesykdommer, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-17135.

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Molekylære metoder for typing av Streptococcus agalactiae med særlig vektlegging av utvikling og validering av et multi-locus variable number of tandem repeats assay (MLVA) Sammendraget: Streptococcus agalactiae eller gruppe B streptokokker (GBS) forårsaker livsfarlige infeksjoner hos nyfødte, gravide eller voksne med kroniske sykdommer. Den forårsaker også jurbetennelse i storfe. Typing av GBS gir innblikk i bakteriens epidemiologi og dens fylogenetiske slektskap. Ulike deler av bakteriene kan være mål for typingsmetoder. Eldre immunologiske metoder fokuserer ofte på overflateegenskaper som polysakkarid- eller proteinstrukturer. Nyere molekylære metoder benytter bakteriens genmateriale til typing. Studien undersøkte om molekylære metoder hadde potensiale til å gi en bedre oppløsning av en stammesamling. I detalj ble typingen av overflateproteiner med både immunologiske og molekylære metoder sammenlignet og en multi-locus variable number of tandem repeats assay (MLVA) ble utviklet og evaluert. Sistnevnte metode er basert på variabiliteten i repeterte områder i bakteriens genom. Sammenligning av sero- og genotyping av GBS overflateproteiner er kompleks på grunn av kryssreaksjoner mellom de ulike proteinene som er sammensatt fra "samme byggesett". Positive resultat for begge metoder ble funnet for 122 av 147 stammer. Av disse hadde 74 % overensstemmende resultater. Ikke overensstemmende resultater ble funnet for tre og delvis overensstemmede resultater for 29 stammer. Utvikling av en MLVA for GBS ble gjort gjennom analyse av publiserte, helgenomer for tre stammer som resulterte i testing av i alt 18 kandidatloci. Videre undersøkelser identifiserte fem loci som ble inkludert i studiens MLVA. En stammesamling av 126 stammer fra nyfødte ble delt inn i 70 grupper av MLVA metoden, noe som representerte en klart overlegen oppløsning sammenlignet med to referansemetoder. Videre ble metodens egnethet for typing av epidemiologisk relaterte stammer demonstrert ved å undersøke 187 stammer som hadde forårsaket jurbetennelse hos storfe. Stammene var samlet inn fra 34 gårder og det ble funnet 37 typer, stort sett en type per gård. På en gård som var representert med 48 stammer ble en forandring av et av MLVA områdene under innsamlingsperioden observert og kan gjenspeile stabiliteten av repeterte områder under in-vivo forhold. Oppsummert ble det vist at immunologiske og molekylære metoder viser overensstemmende eller delvis overensstemmende resultater i det store flertall av stammer. Molekylære metoder er overlegen i typingssammenheng siden det fører til mindre tvetydighet. MLVA metoden for GBS fungerte eksellent i studien og viste veldig god evne til å skille stammene i epidemiologisk relaterte grupper.
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Ng, Sau-wah. "Population genetics study on the variable number of Tandem repeats (VNTR) loci of a Han Chinese population in Hong Kong and its application in human identity." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2292582X.

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Fujita, Kohei. "Association between polyclonal and mixed mycobacterial Mycobacterium avium complex infection and environmental exposure." Kyoto University, 2014. http://hdl.handle.net/2433/188673.

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Books on the topic "Variable number of tandem repeats"

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Threlfall, E. J., J. Wain, and C. Lane. Salmonellosis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0030.

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Salmonellosis remains the second most common form of bacterial food-poisoning in the UK and in most of the developed economies. Although the number of isolations per annum has declined since 2000, over 10,000 laboratory-confirmed cases are recognised each year in England and Wales, and over 150,000 in Europe. Most of infections are associated with contaminated food, particularly of poultry origin, but also may originate from cattle and pigs, and to a lesser extent, sheep. The most common serovars from cases of human infection is Enteritidis, followed by Typhimurium. Contact with pets, particularly reptiles and amphibians is becoming an increasing problem and infections can be severe, particularly in children. Accurate and reproducible methods of identification and subtyping are crucial for meaningful epidemiological investigations, and traditional phenotypic methods of typing are now being supplemented by DNA- based methods such as pulsed-field gel electrophoresis, variable number of tandem repeats analysis, and multilocus sequence typing. The use of such methods in combination with phenotypic methods has been invaluable for outbreak control at the international level. The occurrence of resistance to antimicrobial drugs is an increasing problem, particularly in relation to the development of resistance to antimicrobials regarded as ‘critically-important’ for last resort therapy in humans. Control measures such as vaccination of poultry flocks appear to have had a substantial impact on the number of infections with Salmonella Enteritidis. Nevertheless good hygiene practices in both catering establishments and the home remain essential for the control of infections at the local level.
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Book chapters on the topic "Variable number of tandem repeats"

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Arnemann, J. "Variable number of tandem repeats (VNTRs)." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_3631-1.

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Arnemann, J. "Variable number of tandem repeats (VNTRs)." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_3631.

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Vergnaud, Gilles, and Christine Pourcel. "Multiple Locus Variable Number of Tandem Repeats Analysis." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-999-4_12.

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Wirawan, Adrianto, Chee Keong Kwoh, Li Yang Hsu, and Tse Hsien Koh. "INVERTER: INtegrated Variable numbER Tandem rEpeat findeR." In Communications in Computer and Information Science. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-16750-8_14.

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Yazdankhah, Siamak P., and Bjørn-Arne Lindstedt. "Variable Number Tandem Repeat Typing of Bacteria." In Comparative Genomics. Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-515-2_25.

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Vergnaud, Gilles, and Christine Pourcel. "Multiple Locus VNTR (Variable Number of Tandem Repeat) Analysis." In Molecular Identification, Systematics, and Population Structure of Prokaryotes. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/978-3-540-31292-5_4.

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Brown, T. J., V. N. Nikolayevskyy, and F. A. Drobniewski. "Typing Mycobacterium tuberculosis Using Variable Number Tandem Repeat Analysis." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-207-6_25.

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Breen, Gerome. "Practical Informatics Approaches to Microsatellite and Variable Number Tandem Repeat Analysis." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-367-1_10.

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Hübner, G., K. Battmer, H. Poliwoda, and H. Link. "Analysis of Variable Number of Tandem Repeats Reveals Differences Between Leukemic Cells and Remission Phase Leukocytes." In Haematology and Blood Transfusion / Hämatologie und Bluttransfusion. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78350-0_11.

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Holmlund, G., and B. Lindblom. "Evaluation of Variable Number of Tandem Repeat (VNTR) Alleles in Mother-Child Combinations." In DNA — Technology and Its Forensic Application. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76632-9_14.

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Conference papers on the topic "Variable number of tandem repeats"

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Ang, Kim Loon, Shing Chiang Tan, Chia Sui Ong, and Yun Fong Ngeow. "Finding an optimal loci combination of variable number tandem repeats using genetic algorithms." In 2015 International Symposium on Technology Management and Emerging Technologies (ISTMET). IEEE, 2015. http://dx.doi.org/10.1109/istmet.2015.7359009.

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Ohta, H., J. Shiihara, F. Kudo, et al. "Genetic Polymorphism of Variable Number Tandem Repeat Region of Mucin 4 Might Have Some Relevance to Severe Lung Injury." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6134.

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Rovina, Nikoletta, Simona Karabella, Pantelis Konstantoulakis, et al. "Investigation Of Molecular Fingerprinting Of Mycobacterium Tuberculosis Isolates In New Cases Of Tuberculosis Using Mycobacterial Interspersed Repetitive Unit–Variable Number Tandem Repeat Genotyping (MIRU-VNTR) In Greece." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4766.

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Vlahovic, I., M. Gluncic, K. Dekanic, et al. "Global repeat map algorithm (GRM) reveals differences in alpha satellite number of tandem and higher order repeats (HORs) in human, Neanderthal and chimpanzee genomes – novel tandem repeat database." In 2020 43rd International Convention on Information, Communication and Electronic Technology (MIPRO). IEEE, 2020. http://dx.doi.org/10.23919/mipro48935.2020.9245278.

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O'hara, Patrick J., Frank A. Grant, A. Betty, J. Haldmen, and Mark J. Murray. "Structure of the Human Factor VII Gene." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643786.

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Factor VII is a member of a family of vitamin K-dependent, gamma-carboxylated plasma protein which includes factor IX, factor X, protein C, protein S and prothrombin. Activated factor VII (factor Vila) is a plasma serine protease which participates in a cascade of reactions leading to the coagulation of blood. Two overlapping genomic clones containing sequences encoding human factor VII were isolated and characterized. The complete sequence of the gene was determined and found to span 12.8 kilobases. The mRNA for factor VII as demonstrated by cDNA cloning is polyadenylated at multiple sites but contains only one AAUAAA poly-A signal sequence. The mRNA can undergo alternative splicing forming one transcript containing eight segments as exons and another with an additional exon which encodes a larger pre-pro leader sequence. The portion of the pre-pro leader coded for by the additional exon has no known counterpart in the other vitamin K-dependent proteins. The positions of the introns with respect to the amino acid sequence encoded by the eight essential exons of factor VII are the same as those present in factor IX, factor X, protein C and the first three exons of prothrombin. These exons code for domains generally conserved among members of this gene family, including a pre-pro leader (the essential exon la and alternative exon lb), a gamma-carboxylated domain (exons 2 and 3) a growth factor domain (exons 4 and 5) an activation region (exon 6) and a serine protease (exon 8). The corresponding introns in these genes are dissimilar with respect to size and sequence, with the exception of the third intron in factor VII and protein C. Four introns and a portion of exon 8 in factor VII contain regions made up of tandem repeats of oligonucleotide monomer elements. More than a quarter of the intron sequences and more than a third of the 3' untranslated portion of the mRNA transcript consist of these minisatellite tandem repeats. This type of structure is responsible for polymorphisms due to allelic variation in repeat copy number in other areas of the human genome. Tandem repeats can evolve as a result of random crossover in DNA whose sequence is not maintained by selection. This suggests that much of the sequence information present in the introns and untranslated portion of the message is dispensable.
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6

Lopez, J. A., D. W. Chung, K. Fujikawa, F. S. Hagen, T. Papavannopoulou, and G. J. Roth. "MOLECULAR CLONING OF HUMAN PLATELET GLYCOPROTEIN Ib." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642927.

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Glycoprotein Ib (GPIb) mediates von Willebrand factor-dependent platelet adhesion and participates in the resulting platelet activation process. In the present investigation, the primary structure of human platelet GPIb was studied. GPIb and its proteolytic fragment glycocalicin were purified to near homogeneity from human platelets by affinity chromatography using wheat germ agglutinin and anti-GPIb monoclonal antibody (D. Nugent, University of Washington) coupled to Sepharose. GPIba chain, β chain, and glycocalicin were isolated, reduced and carboxymethylated, and then fragmented by trypsin and S. aureus V8 protease. Peptides were isolated by HPLC and subjected to amino acid sequence analysis. Approximately 200 amino acid residues were identified. Affinity purified rabbit antibodies directed against the a chain, the ft chain, and glycocalicin were prepared and shown to be monospecific by Western blot analysis. Total RNA was prepared from human erythroleukemia cells grown in the presence of phorbol acetate. Poly(A)+ RNA was selected and used to prepare a cDNA library in λgt11. The library was screened with [125]I-labeled polyclonal antibody to glycocalicin. The clone with the largest cDNA insert was sequenced and shown to code for amino acid sequences corresponding to those determined by Edman degradation of glycocalicin. The predicted amino acid sequence contains at least six tandem repeats of 24 amino acids that are highly homologous with 13 repeats present in leucine rich α2 glycoprotein of human plasma. Another region in the protein contains a second repeat rich in threonine and serine, which shows some homology to a 9 amino acid repeat in the connecting region of human factor V. This region is probably the major site of attachment of clusters of O-linked carbohydrate in GPIbα. These results indicate that human platelet glycoprotein Ibα has a multi-domain structure composed of a number of repetitive sequences. Supported in part by grants from the American Heart Association, Robert Wood Johnson Foundation, Veterans Administration, and National Institutes of Health.
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7

Erdmenger, Rodrigo R., Katya Menter, Rogier Giepman, et al. "Development of a New Low-Cost Tandem VGT Concept for Turbocharger Applications." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-77048.

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The air handling system for large diesel/gas engines such as those used on locomotive, marine, and power generation applications require turbochargers with a high reliability and with turbomachinery capable to adjust to different operating conditions and transient requirements. The usage of variable geometry turbocharging (VGT) provides flexibility to the air handling system but adds complexity, cost and reduces the reliability of the turbocharger in exchange for improved engine performance and transient response. For this reason, it was desirable to explore designs that could provide the variability required by the air handling system, without the efficiency penalty of a conventional waste gate and with as little added complexity as possible. The current work describes a new low-cost variable geometry turbine design to address these requirements. The new tandem nozzle concept proposed is applicable to both axial and radial turbines, and has been designed using conventional 1D models and 2D/3D CFD methods. The concept has furthermore been validated experimentally on two different test rigs. In order to avoid the long lead times of procuring castings, the nozzle for the axial turbine was manufactured using new additive manufacturing techniques. Both the axial turbine and the radial turbine designs showed that the concept is capable to achieve a mass flow variability of more than 15% and provide a robust and cost-effective alternative to conventional VGT designs by significantly reducing the number of moveable parts.
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8

Cheng, Hao, Bo Liu, Xiaodong Yang, and Jun Li. "Design and Optimization of Tandem Cascade Based on Parallel Differential Evolution Algorithm." In ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/gt2016-56908.

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A method of tandem airfoil geometry generation and an algorithm of master-slave parallel differential evolution are first developed for the later optimization. An initial tandem cascade is roughly designed and significantly outperforms the original conventional cascade. Based on the parallel differential evolution algorithm and a Navier-Stokes solver, five configuration variables of the initial tandem cascade are then numerically optimized at an inlet Mach number of 0.7 and an approximately minimum-loss incidence of 1.9°. The result shows that the total pressure loss coefficient of the optimum design decreases by 8.67%. The history data of the optimization is statistically analyzed, which reveals the influence levels of the five configuration variables on tandem performance. The performances of the initial and optimum designs at a range of incidence angles are then numerically calculated, showing that the optimum design outperforms the initial design at small or negative incidence angles and performs more poorly at high incidence angles. It is proposed and verified that the different front-rear distributions of camber and chord leads to this phenomenon. Finally, a new-defined variable is proposed to measure the distribution above.
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