Log in

Relevant bibliographies by topics / Variation (Genetics) / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Variation (Genetics).

Dissertations / Theses on the topic 'Variation (Genetics)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Variation (Genetics).'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

De, Bustos Cecilia. "Genetic and Epigenetic Variation in the Human Genome : Analysis of Phenotypically Normal Individuals and Patients Affected with Brain Tumors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6629.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Walker, Tina Kay. "Genetic variation in schistosomes." Thesis, Brunel University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278245.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Pandya, Arpita. "Human Y-chromosomal DNA variation." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298658.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Keightley, Peter D. "Studies of quantitative genetic variation." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/12340.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Loh, Yong-Hwee Eddie. "Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41148.

Full text

Abstract:

Cichlid fishes from the East African Rift lakes Victoria, Tanganyika and Malawi represent a preeminent example of replicated and rapid evolutionary radiation. In this single natural system, numerous morphological (eg. jaw and tooth shape, color patterns, visual sensitivity), behavioral (eg. bower-building) and physiological (eg. development, neural patterning) phenotypes have emerged, much akin to a mutagenic screen. This dissertation encompasses three studies that seek to decipher the underpinnings of such rapid evolutionary diversification, investigated via the genetic variation in East Afri

APA, Harvard, Vancouver, ISO, and other styles

6

Gunn, Melissa Rose School of Biological Earth &amp Environmental Science UNSW. "The use of microsatellites as a surrogate for quantitative trait variation in conservation." Awarded by:University of New South Wales. School of Biological, Earth and Environmental Science, 2003. http://handle.unsw.edu.au/1959.4/22457.

Full text

Abstract:

Conservation biologists are interested in maintaining genetic variation in small populations, with a view to maintaining fitness and the ability of the species to adapt to changing environmental conditions. The most important type of genetic variation is therefore that which affects fitness and reproduction, and is therefore subject to natural selection. Such fitness traits are often quantitative, i.e. are the result of a suite of loci, and are continuously variable. Microsatellite markers are a popular method of determining the level of variation present in a species??? genome. The assumption

APA, Harvard, Vancouver, ISO, and other styles

7

Roussos, Athanasios. "Morphological variation, population genetics and genetic relatedness in three species of Callopora." Thesis, Swansea University, 2007. https://cronfa.swan.ac.uk/Record/cronfa42590.

Full text

Abstract:

The genus Callopora is typical of a very large number of encrusting neocheilostomate genera and can be used to demonstrate the range of autozooid morphology seen in the group. Morphometric analyses of zooid length (ZL), zooid width (ZW), ovicell length (OL) and ovicell width (OW) were conducted in order to study morphological variation in different populations of Callopora dumerilii, Callopora lineata and CaUopora rylandi and to partition the morphological variation within and between sites and colonies for each species using a nested analysis of variance and a principal component analysis app

APA, Harvard, Vancouver, ISO, and other styles

8

Rudd, Danielle Song. "Genomic copy number variation in schizophrenia." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4739.

Full text

Abstract:

Schizophrenia (OMIM 181500) is an incurable and severe psychiatric disorder comprised of three symptom domains (positive symptoms, negative symptoms and cognitive impairments) with a worldwide prevalence of approximately 1%. There is a substantial amount of evidence demonstrating that schizophrenia has a strong a genetic component. Broad-sense heritability estimates range from 64-80% and first-degree relatives of schizophrenia patients have 10-fold increased risk of developing the disorder compared to the general population. It is thought that both single nucleotide polymorphisms and copy numb

APA, Harvard, Vancouver, ISO, and other styles

9

Cotsapas, Chris Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "The genetics of variation in gene expression." Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2005. http://handle.unsw.edu.au/1959.4/30204.

Full text

Abstract:

The majority of genetic differences between species and individuals have been hypothesised to impact on the regulation, rather than the structure, of genes. As the details of genetic variation are uncovered by the various genome sequencing projects, understanding the functional effects on gene regulation will be key to uncovering the molecular mechanisms underying the genesis and inheritance of common phenotypes, such as complex human disease and commercially important traits in plants and animals. Unlike coding sequence polymorphisms, genetic variants affecting gene expression will reside in

APA, Harvard, Vancouver, ISO, and other styles

10

Bromham, Lindell. "Rate variation in DNA sequence evolution." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339362.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Rootsi, Siiri. "Human Y-chromosomal variation in European populations /." Tartu : Tartu University Press, 2004. http://dspace.utlib.ee/dspace/bitstream/10062/1252/5/rootsi.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Goropashnaya, Anna. "Phylogeographic Structure and Genetic Variation in Formica Ants." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3803.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Ehrenreich, Ian Michael. "The Genetics of Phenotypic Variation in Arabidopsis thaliana." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-08062008-162151/.

Full text

Abstract:

All organisms exhibit substantial quantitative trait variation within populations. Such variation is important because it can affect fitness and serve as the substrate for adaptive evolution. Identifying the quantitative trait genes (QTGs) responsible for phenotypic variation is necessary to understand the mechanisms that generate trait variation and to determine the historical action of natural selection on quantitative traits and QTGs. However, in most complex organisms, the genetic mapping of QTGs is difficult and presently not feasible to do systematically at a gene-level resolution. Model

APA, Harvard, Vancouver, ISO, and other styles

14

Russell, Joanne Ritchie. "Molecular variation in Theobroma species." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386981.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Mathieson, Iain. "Genes in space : selection, association and variation in spatially structured populations." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:85f051b6-2121-49cf-9468-3ca7ba77cc4a.

Full text

Abstract:

Spatial structure in a population creates distinctive patterns in genetic data. There are two reasons to model this process. First, since the genetic structure of a population is induced by its historical spatial structure, it can be used to make inference about history and demography. Second, these models provide corrections to other analyses that are confounded by spatial structure. Since is it is now common to collect genome-wide data on many thousands of samples, a major challenge is to develop fast, scalable, approximate algorithms that can analyse these datasets. A practical approach is

APA, Harvard, Vancouver, ISO, and other styles

16

Gresham, David J. "Genetic variation and disease in the Roma (Gypsies)." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2001. https://ro.ecu.edu.au/theses/1516.

Full text

Abstract:

The Roma (Gypsies) are a European people composed of a mosaic of culturally heterogeneous populations. Linguistic analyses point to their origins in the Indian subcontinent. Cultural diversity in extant Romani populations suggests that they are descended from a mixture of Indian populations. Previous population genetic studies of the Roma have supported this claim by demonstrating the genetic heterogeneity of Romani populations. More recently, medical genetic research has detected identical founder mutations in separated Romani populations, which provides evidence of their relatedness. In this

APA, Harvard, Vancouver, ISO, and other styles

17

Archer, Jason Allan. "Genetic variation in the efficiency of feed utilisation by animals." Title page, table of contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09pha6711.pdf.

Full text

Abstract:

Bibliography: leaves 186-200. Analyses feed intake and growth data from cattle, which indicates that genetic variation exists in post-weaning effiency and growth. Concludes with a consideration of how post-weaning feed intake information can be used in genetic improvement programs.

APA, Harvard, Vancouver, ISO, and other styles

18

Rogell, Björn. "Genetic variation and local adaptation in peripheral populations of toads." Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107395.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Murtagh, Gareth James. "Sex and variation in lichen-forming fungi." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285566.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Stewart, John E. B. (John Edward Bakos). "Genetic Variation in a Population of the Plains Woodrat Neotoma micropus." Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc500709/.

Full text

Abstract:

Neotoma micropus from Jack County, Texas, were studied over a 9-month period. Loci from blood and saliva were used to determine genetic variation within the population. Deviations from Hardy-Weinberg equilibrium were found at one locus. The average temporal F over all seven loci was 0.040. Genetic structuring was subtle, fluctuated on a seasonal basis, and was due to differential migration or predation on genotypes. Heterozygotes tended to move more than homozygotes, and a greater proportion of heterozygotes were lost from the population during each season. Genetic variation was maintained in

APA, Harvard, Vancouver, ISO, and other styles

21

Elis, Mabon. "Evolutionary genetics of flower colour variation in Antirrhinum." Thesis, University of East Anglia, 2018. https://ueaeprints.uea.ac.uk/69572/.

Full text

Abstract:

Phenotypic differences between species and populations can reveal much about how they have adapted and responded to a complex set of environmental cues. Studies have shown that genetic control of some traits is centralised to single genomic regions, while others are regulated at many unlinked loci dispersed throughout the genome. One trait that shows an enormous degree of variation between plant species is flower colour, and its tractability makes it an ideal trait for studying genetic differences underlying species differentiation. Antirrhinum majus has long been used as a model for studying

APA, Harvard, Vancouver, ISO, and other styles

22

Rowell, Jennie Lynn. "GENETIC VARIATION IN THE DOMESTICATED DOG AS A MODEL OF HUMAN DISEASE." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338237356.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

SUSCA, Roberta Rosa. "Patterns of genetic and linguistic variation. A study of uniparental markers." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2488149.

Full text

Abstract:

This dissertation is divided in three sections and focuses on two of the projects I worked on during my three-years PhD, funded by a European Research Council (ERC) grant LanGeLin. Both the projects share the uniparental markers as tool used for the investigation of the human evolutionary history, but each of them addresses different scientific questions by means of a different combination of molecular and statistical methods. Part I is a technical summary on current knowledge about uniparental markers features and on the pros and cons of their usage for addressing questions stemming from th

APA, Harvard, Vancouver, ISO, and other styles

24

Hamilton, Katherine Elaine. "Structural and regulatory gene variation in Salmonid fishes." Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356872.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

De, Winter Gunnar. "The ecology and evolution of individual behavioural variation." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/44995/.

Full text

Abstract:

Central to this thesis is the investigation of how several factors (e.g. morphology, ecology, and social conditions) co-vary with consistent individual behavioural variation. Additionally, conceptual work explores the reach of consistent inter-individual behavioural variation in several novel contexts. In doing so, the aim is to contribute novel findings to the quickly growing compendium of knowledge concerning 'animal personality' in various settings. In summary, during this PhD the following research has been performed: • Through the use of lab-reared juvenile three-spined stickleback (Gaste

APA, Harvard, Vancouver, ISO, and other styles

26

Fredman, David. "Computational exploration of human genome variation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-025-7/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Kvernes, Macpherson Carina. "Studying genetics of leaf shape variation in Arabidopsis lyrata." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-160116.

Full text

Abstract:

The relationship between leaf and its environment has resulted in a tremendous diversification of leaf shape within and between plants species, which is important to cope with the differing environmental conditions. Arabidopsis lyrata is a prime model plant that shows leaf shape variation within species and between related species. In Cardamine and Capsella, the RCO genes (homeodomain leucine zipper family transcription factors) are involved in shaping leaves, yielding more complex shaped leaves (leaflets). In A. thaliana, over the course of evolution, the RCO-A and RCO-B paralogous genes have

APA, Harvard, Vancouver, ISO, and other styles

28

Marcar, Nico Emile. "Genotypic variation for manganese efficiency in cereals /." Title page, abstract and contents only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phm313.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Scheet, Paul A. "A flexible and computationally tractable model for patterns of population genetic variation/." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8932.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Patel, Tulsi. "Investigating genetic variation in Alzheimer's disease." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52447/.

Full text

Abstract:

Alzheimer's disease (AD) is the most common form of dementia, now the leading cause of death in the UK, which affects more than 35 million people worldwide. Genome-wide association studies identified 20 genetic loci associated with disease susceptibility, however these only exerted small effects on risk. Next-generation sequencing is now being employed to identify more of the missing heritability. This project utilised whole-exome sequencing to explore genetic variation using the Brains for Dementia Research (BDR) resource, a well-characterised cohort of neuropathologically confirmed samples.

APA, Harvard, Vancouver, ISO, and other styles

31

Young, J. R. "The molecular genetics of antigenic variation in Trypanosoma brucei." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372285.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Forsberg, Lena. "Genetic variation and regulation of oxidative stress related genes /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4241-2/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Sharkey, Andrew M. "Genetic variation in the rodent malaria parasite Plasmodium chabaudi." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/14391.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Whiteley, Rachel. "Quantitative and molecular genetic variation in Ulmus laevis Pall. /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/s313.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Cardno, Alastair George. "The quantitative genetics of clinical variation in psychotic illnesses." Thesis, Cardiff University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394591.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Modin, Helena. "Multiple sclerosis : linkage analysis and DNA variation in a complex trait /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-792-4/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Shringarpure, Suyash. "Statistical Methods for studying Genetic Variation in Populations." Research Showcase @ CMU, 2012. http://repository.cmu.edu/dissertations/117.

Full text

Abstract:

The study of genetic variation in populations is of great interest for the study of the evolutionary history of humans and other species. Improvement in sequencing technology has resulted in the availability of many large datasets of genetic data. Computational methods have therefore become quite important in analyzing these data. Two important problems that have been studied using genetic data are population stratification (modeling individual ancestry with respect to ancestral populations) and genetic association (finding genetic polymorphisms that affect a trait). In this thesis, we develop

APA, Harvard, Vancouver, ISO, and other styles

38

Ochola, Harold Martin Owino. "Using genomics and population genetics to understand genetic variation in Malawi Plasmodium falciparum clinical isolates." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/15753/.

Full text

Abstract:

The natural selection imposed by host immunity and antimalarial drugs has driven extensive adaptive evolution in Plasmodium falciparum, leading to an ever-changing landscape of genetic variation. We have carried out whole-genome sequencing of 93 P. falciparum clinical isolates from Malawi and used population genetic methods to investigate the genetic diversity and regions under selection. In addition, by computing XP-EHH, PCA and FST we have compared the Malawi isolates to five dispersed others (Kenya, Mali, Burkina Faso, Cambodia and Thailand), and identified genes potentially under positive

APA, Harvard, Vancouver, ISO, and other styles

39

Lee, Peter Daniel. "Building a model for mapping genetic variation affecting gene expression." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85931.

Full text

Abstract:

The majority of genetic traits including most common diseases are believed to be multigenic and arise both from variations in coding sequences as well as from regulatory polymorphisms. Genome-wide approaches are needed to develop models for understanding this complexity. This thesis develops approaches for studying genetic variation affecting gene expression on a genome-wide scale. This included development of experimental design principles and analytical methods for microarray data. These principles were then applied to characterize differences between commonly-used A/J and C57BL/6J in

APA, Harvard, Vancouver, ISO, and other styles

40

Whittaker, S. L. "Genetics of P. infestans - variation in DNA content and ploidy." Thesis, Bangor University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280024.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Yue, Wei. "Characterization of genetic variation in secondary metabolites in Fusarium." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/36235.

Full text

Abstract:

Doctor of Philosophy<br>Genetics Interdepartmental Program<br>Christopher Toomajian<br>Secondary metabolites (SMs), low molecular weight molecules that are not essential for normal organism growth and development, may confer a selective advantage in some environments. Fungal SMs are structurally and functionally diverse and include mycotoxins, plant regulators and pigments, and the genes that work together in SM biosynthetic pathways are physically clustered in the genome. Fusarium, a genus of filamentous fungi, is noted for SM production, especially mycotoxins, which may contribute to plant p

APA, Harvard, Vancouver, ISO, and other styles

42

King, Rachel, and n/a. "Spatial Structure and Population Genetic Variation in a Eucalypt Species Complex." Griffith University. Australian School of Environmental Studies, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050113.091713.

Full text

Abstract:

In this study, the relative influences of selection, gene flow, and other evolutionary forces on the spatial structure of genetic variation within a eucalypt species complex (the spotted gums: genus Corymbia, section Politaria) were assessed. The study investigated the spatial genetic structure among four putative species of spotted gum (broad-scale), as well as within a single population (fine-scale)of one species, using both molecular and quantitative markers. The spotted gum complex occurs naturally across a range of 2500 km in eastern Australia. Spatial genetic variation within and between

APA, Harvard, Vancouver, ISO, and other styles

43

King, Rachel. "Spatial Structure and Population Genetic Variation in a Eucalypt Species Complex." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/365496.

Full text

Abstract:

In this study, the relative influences of selection, gene flow, and other evolutionary forces on the spatial structure of genetic variation within a eucalypt species complex (the spotted gums: genus Corymbia, section Politaria) were assessed. The study investigated the spatial genetic structure among four putative species of spotted gum (broad-scale), as well as within a single population (fine-scale)of one species, using both molecular and quantitative markers. The spotted gum complex occurs naturally across a range of 2500 km in eastern Australia. Spatial genetic variation within and between

APA, Harvard, Vancouver, ISO, and other styles

44

Judson, Olivia P. "Parasites, sex and genetic variation in a model metapopulation." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296922.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Goulson, David. "Maintenance of phenotypic variation in the butterfly, Maniola jurtina." Thesis, Oxford Brookes University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293305.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Smith, Thomas C. A. "Within genome variation of germ-line and somatic mutation." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/68212/.

Full text

Abstract:

Variation in the mutation rate along the human genome, if not properly understood and accounted for, has the potential to confound evolutionary studies, produce spurious driver candidates in cancer studies, and hinder the diagnostics aimed at understanding the etiologies of genetic diseases. In this thesis I consider mutation rate variation in both the germ-line and somatic tissues, at varying scales. In the germ-line, the major advance of this thesis over previous works is use of direct methods to analyse the magnitude, scale and determinants of mutation rate variation. This has enabled us to

APA, Harvard, Vancouver, ISO, and other styles

47

SSEKIMPI, PUPULIO SSEMOMBWE NKUNA ABBY. "CHROMOSOME VARIATION IN DROSOPHILA SPECIES OF THE MULLERI COMPLEX." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183809.

Full text

Abstract:

Drosophila species in mulleri complex show five rod-shaped and one pair of dot-shaped chromosome. The sex-chromosomes represent the largest pair in the female, but are heteromorphic in the male, the Y-chromosome being shorter than the X-chromosome. The purpose of the research presented here is to determine whether chromosomes in the mulleri cluster species are longer than in the mojavensis cluster. The length of X-, Y-chromosomes and the rod-like autosomes were compared among the ten species studied. All the rod-like chromosomes were measured in 30 or more brain cells in each of the ten specie

APA, Harvard, Vancouver, ISO, and other styles

48

Barrera, Luis A. "Towards a Systematic Approach for Characterizing Regulatory Variation." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718710.

Full text

Abstract:

A growing body of evidence suggests that genetic variants that alter gene expression are responsible for many phenotypic differences across individuals, particularly for the risk of developing common diseases. However, the molecular mechanisms that underlie the vast majority of associations between genetic variants and their phenotypes remain unknown. An important limiting factor is that genetic variants remain difficult to interpret, particularly in noncoding sequences. Developing truly systematic approaches for characterizing regulatory variants will require: (a) improved annotations for th

APA, Harvard, Vancouver, ISO, and other styles

49

Sawyer, Sarah Lynn. "Using SNPs to study complex genetic disease : a population and evolutionary genetics perspective /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-967-6/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Johansson, Åsa. "Genome Variation in Human Populations : Exploring the Effects of Demographic History and the Potential for Mapping of Complex Traits." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7293.

Full text

Abstract:

<p>A major challenge in human genetics is to understand the genetic variation underlying common diseases. In this thesis, I focus on forces creating differences between individuals and genomic regions, methods for characterizing genomic variation, and the association between genomic and phenotypic variation. Genetic markers are widely used to locate genes associated with different phenotypes. In my first paper, I describe novel algorithms for automatic genotype determination of microsatellite markers, a procedure which is currently both time-consuming and error prone. </p><p>The co-segregation

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!