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Journal articles on the topic 'Varicellka vaccine'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Srinivas, G., D.V. Ramanjaneyulu, E. Muralinath, et al. "Indications, Mechanism of Action, Administration, Adverse Effects, Contra Indications, Relative Contra Indications and Toxicity MMR Vaccine." Research and Reviews: Neonatal and Pediatric Nursing 3, no. 2 (2025): 1–13. https://doi.org/10.5281/zenodo.15517148.

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<em>Measles-containing vaccines are </em><em>accepted by the US Food and Drug Administration (FDA) and </em><em>utilized for the routine immunization of children and adolescents. These vaccines are also</em><em> highly recommended for adults born after 1970 who have not been immunized. Adults who were born prior to 1970 are typically considered to have developed a natural immunity to measles. In order to protect themselves from potential infection, vulnerable individuals, including healthcare workers, military people, and visitors from outside North America, should get the measles, mumps, and

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Srinivas, G., D.V. Ramanjaneyulu, E. Muralinath, et al. "A Fundamental Parameters of MMR Vaccine Include Indications, Mechanism of Action, Administration, Adverse Effects, Contra Indications, Relative Contra Indications and Toxicity." Journal of Research and Development in Pharmacological Practices 1, no. 1 (2025): 73–83. https://doi.org/10.5281/zenodo.15488368.

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<em>As approved by the US Food and Drug Administration (FDA), measles-containing vaccinations are used to vaccinate children and adolescents on a regular basis. Adults born after 1970 who have not received these vaccinations are likewise strongly advised to do so. Adults born prior to 1970 are typically considered to have developed a natural immunity to measles. Regardless of the situation, vulnerable individuals, including healthcare workers, military people, and visitors from outside North America, should have the measles, mumps, and rubella (MMR) vaccine to protect against very high risk of

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Elizondo-Alzola, Usue, Mireia G. Carrasco, Laia Pinós, Camila Andrea Picchio, Cristina Rius, and Elia Diez. "Vaccine hesitancy among paediatric nurses: Prevalence and associated factors." PLOS ONE 16, no. 5 (2021): e0251735. http://dx.doi.org/10.1371/journal.pone.0251735.

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Objective This study describes the prevalence of vaccine hesitancy associated with the Catalan systematic childhood vaccination calendar and some related psychosocial determinants among paediatric primary care nurses in Barcelona (Spain). Methods Cross-sectional descriptive study. In 2017 we invited the paediatric nurses (N = 165) working in Barcelona public primary health centres with paediatric departments (N = 41) to participate. They answered a questionnaire with sociodemographic and behavioural variables: severity and perceived probability of contracting the diseases of the vaccines in th

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Wang, Wei, Dequan Pan, Tong Cheng, and Hua Zhu. "Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives." Viruses 14, no. 5 (2022): 848. http://dx.doi.org/10.3390/v14050848.

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Primary varicella-zoster virus (VZV) infection causes varicella, which remains a prominent public health concern in children. Current varicella vaccines adopt the live-attenuated Oka strain, vOka, which retains the ability to infect neurons, establish latency and reactivate, leading to vaccine-associated zoster in some vaccinees. Therefore, it is necessary to develop a safer next-generation varicella vaccine to help reduce vaccine hesitancy. This paper reviews the discovery and identification of the skin- and neuro-tropic factor, the open reading frame 7 (ORF7) of VZV, as well as the developme

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Tillieux, Sueli L., Wendy S. Halsey, Elizabeth S. Thomas, John J. Voycik, Ganesh M. Sathe, and Ventzislav Vassilev. "Complete DNA Sequences of Two Oka Strain Varicella-Zoster Virus Genomes." Journal of Virology 82, no. 22 (2008): 11023–44. http://dx.doi.org/10.1128/jvi.00777-08.

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ABSTRACT Varicella-zoster virus (VZV) is a herpesvirus and is the causative agent of chicken pox (varicella) and shingles (herpes zoster). Active immunization against varicella became possible with the development of live attenuated varicella vaccine. The Oka vaccine strain was isolated in Japan from a child who had typical varicella, and it was then attenuated by serial passages in cell culture. Several manufacturers have obtained this attenuated Oka strain and, following additional passages, have developed their own vaccine strains. Notably, the vaccines Varilrix and Varivax are produced by

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Brunell, Philip A., Valerio M. Novelli, Susan V. Lipton, and Betsy Pollock. "Combined Vaccine Against Measles, Mumps, Rubella, and Varicella." Pediatrics 81, no. 6 (1988): 779–84. http://dx.doi.org/10.1542/peds.81.6.779.

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A combined measles, mumps, rubella, and varicella vaccine produced seroconversions for all four components similar to that found if measles, mumps, and rubella vaccine or live varicella vaccine were given separately. In addition, those exposed to varicella were completely protected or had only a mild rash. Moreover, the reaction rates were not increased if the vaccines were combined. The somewhat lower and delayed serologic response to live varicella vaccine as compared with the combined measles, mumps, rubella, and varicella may have been due to the small amount of varicella vaccine virus use

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Aoki, Takahiro, Katsuyoshi Koh, Yutaka Kawano, et al. "Use of the Japanese Live Attenuated High-Titer Varicella Vaccine in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients." Blood 124, no. 21 (2014): 2505. http://dx.doi.org/10.1182/blood.v124.21.2505.2505.

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Abstract Background: Hematopoietic stem cell transplantation (HSCT) recipients carry a high risk of primary varicella and varicella-zoster virus (VZV) reactivation. VZV infections can be fatal, and VZV reactivation can be complicated by postherpetic neuralgia, which worsens the recipients’ post-HSCT quality of life. VZV vaccines may prevent such infections; however, international vaccination guidelines do not recommend VZV vaccination of HSCT recipients because few data regarding safety among HSCT recipients are available. In Japan, we use a high-titer Oka stain vaccine for varicella vaccinati

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8

Weinmann, Sheila, Stephanie Irving, Padma Koppolu, et al. "2767. Variation in Incidence of Pediatric Herpes Zoster by First- and Second-Dose Varicella Vaccine Formulations." Open Forum Infectious Diseases 6, Supplement_2 (2019): S975—S976. http://dx.doi.org/10.1093/ofid/ofz360.2444.

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Abstract Background Varicella (VAR) and measles-mumps-rubella (MMR) vaccines are recommended for children at ages 12–15 months and 4–6 years. These are administered as separate MMR and VAR vaccines (MMR+VAR) or as combined measles-mumps-rubella-varicella (MMRV) vaccine. Herpes zoster (HZ), caused by wild-type or vaccine-strain varicella-zoster virus, can occur in children after varicella vaccination. It is unknown whether HZ incidence after varicella vaccination varies by vaccine formulation or simultaneous receipt of MMR. Methods Using data from six integrated health systems, we examined HZ i

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Cao, Han, Yunfei Wang, Ning Luan, and Cunbao Liu. "Immunogenicity of Varicella-Zoster Virus Glycoprotein E Formulated with Lipid Nanoparticles and Nucleic Immunostimulators in Mice." Vaccines 9, no. 4 (2021): 310. http://dx.doi.org/10.3390/vaccines9040310.

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Theoretically, the subunit herpes zoster vaccine ShingrixTM could be used as a varicella vaccine that avoids the risk of developing shingles from vaccination, but bedside mixing strategies and the limited supply of the adjuvant component QS21 have made its application economically impracticable. With lipid nanoparticles (LNPs) that were approved by the FDA as vectors for severe acute respiratory syndrome coronavirus 2 vaccines, we designed a series of vaccines efficiently encapsulated with varicella-zoster virus glycoprotein E (VZV-gE) and nucleic acids including polyinosinic-polycytidylic aci

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Lee, Chanyeong, Minjee Kim, Jungmin Chun, et al. "Baculovirus Vector-Based Varicella-Zoster Virus Vaccine as a Promising Alternative with Enhanced Safety and Therapeutic Functions." Vaccines 12, no. 3 (2024): 333. http://dx.doi.org/10.3390/vaccines12030333.

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Varicella-zoster virus (VZV) poses lifelong risks, causing varicella and herpes zoster (HZ, shingles). Currently, varicella and HZ vaccines are predominantly live attenuated vaccines or adjuvanted subunit vaccines utilizing VZV glycoprotein E (gE). Here, we propose our vaccine candidates involving a comparative analysis between recombinant baculoviral vector vaccines (AcHERV) and a live attenuated vaccine strain, vOka. AcHERV vaccine candidates were categorized into groups encoding gE only, VZV glycoprotein B (gB) only, or both gE and gB (gE-gB) as AcHERV-gE, AcHERV-gB, and AcHERV-gE-gB, respe

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Luan, Ning, Han Cao, Yunfei Wang, Kangyang Lin, and Cunbao Liu. "Ionizable Lipid Nanoparticles Enhanced the Synergistic Adjuvant Effect of CpG ODNs and QS21 in a Varicella Zoster Virus Glycoprotein E Subunit Vaccine." Pharmaceutics 14, no. 5 (2022): 973. http://dx.doi.org/10.3390/pharmaceutics14050973.

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Varicella zoster virus (VZV) causes two diseases: varicella upon primary infection and herpes zoster when latent viruses in the sensory ganglia reactivate. While varicella vaccines depend on humoral immunity to prevent VZV infection, cell-mediated immunity (CMI), which plays a therapeutic role in the control or elimination of reactivated VZV in infected cells, is decisive for zoster vaccine efficacy. As one of the most abundant glycoproteins of VZV, conserved glycoprotein E (gE) is essential for viral replication and transmission between ganglion cells, thus making it an ideal target subunit v

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Thiele, Sonja, Aljona Borschewski, Judit Küchler, Marc Bieberbach, Sebastian Voigt, and Bernhard Ehlers. "Molecular Analysis of Varicella Vaccines and Varicella-Zoster Virus from Vaccine-Related Skin Lesions." Clinical and Vaccine Immunology 18, no. 7 (2011): 1058–66. http://dx.doi.org/10.1128/cvi.05021-11.

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ABSTRACTTo prevent complications that might follow an infection with varicella-zoster virus (VZV), the live attenuated Oka strain (V-Oka) is administered to children in many developed countries. Three vaccine brands (Varivax from Sanofi Pasteur MSD; Varilrix and Priorix-Tetra, both from Glaxo-Smith-Kline) are licensed in Germany and have been associated with both different degrees of vaccine effectiveness and adverse effects. To identify genetic variants in the vaccines that might contribute to rash-associated syndromes, single nucleotide polymorphism (SNP) profiles of variants from the three

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Liu, Hongjing, Lingyan Cui, Sibo Zhang, et al. "Research Progress on Varicella-Zoster Virus Vaccines." Vaccines 13, no. 7 (2025): 730. https://doi.org/10.3390/vaccines13070730.

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Varicella-zoster virus (VZV) poses significant public health challenges as the etiological agent of varicella (chickenpox) and herpes zoster (HZ), given its high transmissibility and potential for severe complications. The introduction of VZV vaccines—particularly the vOka-based live attenuated and glycoprotein gE-based recombinant subunit vaccines—has substantially reduced the global incidence of these diseases. However, live attenuated vaccines raise concerns regarding safety and immunogenicity, especially in immunocompromised populations, while recombinant subunit vaccines, such as Shingrix

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Alharbi, Sadan, Mohammed Alsubaie, Remah Alzayyat, Batool Alattas, Hassan AlAhmadi, and Hanoof Alabdullatif. "Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature." Medical Archives 77, no. 2 (2023): 142. http://dx.doi.org/10.5455/medarh.2023.77.142-144.

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Background: According to WHO, there have been 9205 fatal COVID-19 cases confirmed in Saudi Arabia out of 793,729 cases overall (5). During the development of COVID-19 vaccines, several technologies were used including DNA-based, RNA-based vaccines, non-replicating viral vector vaccines, and inactivated vaccines. Objective: We present a case of varicella zoster virus reactivation post COVID-19 vaccine in a young medically free 16 years old female and review of the literature using the keywords “Herpes Zoster, “varicella zoster”,” shingles”, “post COVID-19 vaccine”, “Post COVID-19 cutaneous mani

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Alharbi, Sadan, Mohammed Alsubaie, Remah Alzayyat, Batool Alattas, Hassan AlAhmadi, and Hanoof Alabdullatif. "Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature." Medical Archives 77, no. 2 (2023): 146. http://dx.doi.org/10.5455/medarh.2023.77.146-149.

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Background: According to WHO, there have been 9205 fatal COVID-19 cases confirmed in Saudi Arabia out of 793,729 cases overall (5). During the development of COVID-19 vaccines, several technologies were used including DNA-based, RNA-based vaccines, non-replicating viral vector vaccines, and inactivated vaccines. Objective: We present a case of varicella zoster virus reactivation post COVID-19 vaccine in a young medically free 16 years old female and review of the literature using the keywords “Herpes Zoster, “varicella zoster”,” shingles”, “post COVID-19 vaccine”, “Post COVID-19 cutaneous mani

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Bricks, Lucia Ferro, Helena Keico Sato, and Gabriel Wolf Oselka. "Varicella vaccines and measles, mumps, rubella, and varicella vaccine." Jornal de Pediatria 82, no. 7 (2006): 101–8. http://dx.doi.org/10.2223/jped.1496.

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Wang, Hong, Sibo Zhang, Wenhui Xue, et al. "Glycoprotein E-Displaying Nanoparticles Induce Robust Neutralizing Antibodies and T-Cell Response against Varicella Zoster Virus." International Journal of Molecular Sciences 25, no. 18 (2024): 9872. http://dx.doi.org/10.3390/ijms25189872.

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The Varicella zoster virus (VZV), responsible for both varicella (chickenpox) and herpes zoster (shingles), presents significant global health challenges. While primary VZV infection primarily affects children, leading to chickenpox, reactivation in later life can result in herpes zoster and associated post-herpetic neuralgia, among other complications. Vaccination remains the most effective strategy for VZV prevention, with current vaccines largely based on the attenuated vOka strains. Although these vaccines are generally effective, they can induce varicella-like rashes and have sparked conc

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Edwin, Dias, Dias Anusha, and Baburaj Abith. "Common Vaccinations in Infants and Children- A Brief Review." International Journal of Health Sciences and Pharmacy 3, no. 2 (2020): 11. https://doi.org/10.5281/zenodo.3613403.

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ABSTRACT  There  is an  increasing worldwide  realization  that  immunization uptake rates  in children and  infants are  less  than required for adequate control of vaccine preventable diseases. Vaccines  consists  of  attenuated,  inactivated  or  killed  organisms  modified  toxins  or  subunits.  Good  vaccines are simple to administer, free of toxic components and induces permanent immunity.  Childhood vaccinations not only protect a child from deadly diseases  like

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Hartley, Christopher, Tina Thomas, Sara Kathryn Smith, and Wikrom Karnsakul. "Live-Attenuated Vaccines in Pediatric Solid Organ Transplant." Vaccines 12, no. 4 (2024): 376. http://dx.doi.org/10.3390/vaccines12040376.

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Measles, mumps, rubella (MMR), and varicella incidence rates have increased due to the delayed vaccination schedules of children secondary to the COVID-19 pandemic. Decreased herd immunity creates a risk for immunocompetent children and immunocompromised individuals in the community. Historically, live-attenuated vaccines (MMR and varicella) were recommended before solid organ transplants. The amount of time before transplant when this is appropriate is often debated, as is the utility of vaccine titers. MMR and varicella vaccines previously were not recommended in immunocompromised patients p

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Marra, Yasmin, and Fawziah Lalji. "Prevention of Herpes Zoster: A Focus on the Effectiveness and Safety of Herpes Zoster Vaccines." Viruses 14, no. 12 (2022): 2667. http://dx.doi.org/10.3390/v14122667.

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Infection with varicella zoster virus typically occurs in children and it can cause primary varicella infection or “chickenpox”, or it can reactivate later in life and cause herpes zoster or “shingles”. Herpes zoster mainly occurs in older adults, causing a reduction in activities of daily living, impacting quality of life, and may lead to serious complications, including chronic pain. Two vaccines are marketed to prevent herpes zoster: the live zoster vaccine and the non-live, recombinant zoster vaccine. The pre-licensure clinical trials show the efficacy of the live zoster vaccine to be betw

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Pickering, Larry K., Carol J. Baker, Gary L. Freed, et al. "Immunization Programs for Infants, Children, Adolescents, and Adults: Clinical Practice Guidelines by the Infectious Diseases Society of America." Clinical Infectious Diseases 49, no. 6 (2009): 817–40. http://dx.doi.org/10.1086/605430.

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Abstract Evidence-based guidelines for immunization of infants, children, adolescents, and adults have been prepared by an Expert Panel of the Infectious Diseases Society of America (IDSA). These updated guidelines replace the previous immunization guidelines published in 2002. These guidelines are prepared for health care professionals who care for either immunocompetent or immunocompromised people of all ages. Since 2002, the capacity to prevent more infectious diseases has increased markedly for several reasons: new vaccines have been licensed (human papillomavirus vaccine; live, attenuated

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D'Ancona, F., V. Alfonsi, M. R. Caporali, A. Ranghiasci, and M. L. Ciofi Degli Atti. "Pneumococcal conjugate, meningococcal C and varicella vaccination in Italy." Eurosurveillance 12, no. 2 (2007): 9–10. http://dx.doi.org/10.2807/esm.12.02.00685-en.

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The 7-valent anti-pneumococcal conjugate vaccine (PCV), anti-meningococcal C-conjugate vaccine (MenC) and varicella vaccine have been recently introduced in EU. In Italy, these vaccines have so far been recommended for use in specific groups. Since the health system is decentralised, the Regional Health Authorities (RHAs) can decide to recommend vaccination for other target populations. We conducted a survey to describe the recommendations on these vaccines currently in place in the 21 Italian regions. In November 2005, a standardised questionnaire was sent to RHAs, including information on th

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HURST, PETER L. "Questions About Varicella Vaccine." Pediatrics 98, no. 6 (1996): 1225–26. http://dx.doi.org/10.1542/peds.98.6.1225b.

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Plotkin's informative commentary entitled "Varicella Vaccine" cites reservations of "many American pediatricians" as reason for the vaccine's low acceptance. From a public health perspective, I question whether use of a vaccine ought to be determined by individual physicians instead of groups of experts like the Committee on Infectious Diseases of the American Academy of Pediatrics. I also wonder whether the reluctance to endorse the vaccine is not related to its cost. An informal survey disclosed a range of $60 to $100 per immunization.

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Shanmuga, Priya C., M. Shalini, M. Sanjay, V. Anil Akshara, B.* Hardha, and Kumar M. Senthil. "REVIEW ON VACCINES VARIOUS PRODUCTION, TRENDS, CHALLENGES AND EFFICACY." World Journal of Pharmaceutical Science and Research 2 (December 1, 2023): 220–38. https://doi.org/10.5281/zenodo.10935668.

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Almost thirty of the infectious diseases that are pathogenic for humans are protected by vaccinations. The majority of vaccines, particularly those used to prevent diseases in children, are quite effective and have a good safety record. Vaccines are produced to protect against a wide range of additional bacteria, viruses, and parasites. To examine the impact of sociodemographic factors and information systems on current treads as well as the viability of meeting the goal of 95% coverage for the paediatric immunization schedule. The vaccination campaign is an ongoing global initiative to immuni

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Gajurel, Kiran, Tue Ngo, Robert T. Fairman, and Lewis H. McCurdy. "Vaccination in Kidney Transplant Candidates." Transplantation Direct 9, no. 10 (2023): e1544. http://dx.doi.org/10.1097/txd.0000000000001544.

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Background: Kidney transplant (KT) candidates have historically low immunization rates against recommended vaccines. A retrospective single-center study of contemporary KT candidates was conducted to assess vaccination rates and vaccine uptake. Methods: All KT candidates ≥18 y evaluated between January 1, 2020, and December 31, 2020, were retrospectively reviewed for history of prior vaccination against tetanus, diphtheria, and pertussis; 13-valent pneumococcal conjugate vaccine; 23-valent pneumococcal polysaccharide vaccine; and recombinant zoster vaccine. Positive hepatitis A IgG total, hepa

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WHITE, C. J. "Varicella Vaccine Reflux." Pediatrics 89, no. 2 (1992): 354. http://dx.doi.org/10.1542/peds.89.2.354.

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In Reply.— Herpes zoster (shingles) is the dermatomal skin eruption resulting from the reactivation of varicella-zoster virus remaining latent in posterior sensory root ganglia following childhood chickenpox (the primary infection with varicella-zoster virus). Since the live attenuated varicella-zoster virus contained in the vaccine replicates in the vaccinee similar to the wild-type virus, establishment of latency is possible for the attenuated strain. Several publications have addressed latency of the attenuated virus following immunization. Two studies have examined the incidence of zoster

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Camara, Aichetou, Anaïs Razurel, Christelle Moreau, et al. "P44 Vaccine in pediatric chronic kidney disease (CKD) and hemodialysis." Archives of Disease in Childhood 105, no. 9 (2020): e29.2-e30. http://dx.doi.org/10.1136/archdischild-2020-nppg.53.

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AimsChronic kidney disease is a major risk factor of vaccine preventable infectious diseases due to the altered immune system and the natural evolution of the disease. There are differences in the prescription of some vaccines for this population. The aim of this study is to elaborate a vaccination protocol for chronic kidney disease and haemodialysis patients for a better immunization coverage, care and prevention against preventable infectious diseases.MethodsThe study was conducted by a multidisciplinary team composed by pharmacists, infectious disease paediatrician and nephrology paediatri

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Zhang, Lingli, Xin Li, Jiali Chen, Xiaoye Wang, and Yuyang Sun. "Public Preference and Priorities for Including Vaccines in China’s National Immunization Program: Discrete Choice Experiment." JMIR Public Health and Surveillance 10 (November 14, 2024): e57798-e57798. http://dx.doi.org/10.2196/57798.

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Abstract Background Several important vaccines, such as the Haemophilus influenzae type b vaccine, rotavirus vaccine, pneumococcal conjugate vaccine, and influenza vaccine, have not been included in China’s National Immunization Program (NIP) due to a prolonged absence of updates and limited resources. Public engagement could identify concerns that require attention and foster trust to ensure continuous support for immunization. Objective This study aimed to identify public preferences for vaccine inclusion in the NIP and to determine the desired vaccine funding priorities in the Chinese popul

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Depledge, Daniel P., Koichi Yamanishi, Yasuyuki Gomi, Anne A. Gershon, and Judith Breuer. "Deep Sequencing of Distinct Preparations of the Live Attenuated Varicella-Zoster Virus Vaccine Reveals a Conserved Core of Attenuating Single-Nucleotide Polymorphisms." Journal of Virology 90, no. 19 (2016): 8698–704. http://dx.doi.org/10.1128/jvi.00998-16.

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ABSTRACTThe continued success of the live attenuated varicella-zoster virus vaccine in preventing varicella-zoster and herpes zoster is well documented, as are many of the mutations that contribute to the attenuation of the vOka virus for replication in skin. At least three different preparations of vOka are marketed. Here, we show using deep sequencing of seven batches of vOka vaccine (including ZostaVax, VariVax, VarilRix, and the Oka/Biken working seed) from three different manufacturers (VariVax, GSK, and Biken) that 137 single-nucleotide polymorphism (SNP) mutations are present in all vac

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Feldman, Amy G., Brenda L. Beaty, Jose A. Ferrolino, et al. "Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients." JAMA Network Open 6, no. 10 (2023): e2337602. http://dx.doi.org/10.1001/jamanetworkopen.2023.37602.

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ImportanceLive vaccines (measles-mumps-rubella [MMR] and varicella-zoster virus [VZV]) have not been recommended after solid organ transplant due to concern for inciting vaccine strain infection in an immunocompromised host. However, the rates of measles, mumps, and varicella are rising nationally and internationally, leaving susceptible immunocompromised children at risk for life-threating conditions.ObjectiveTo determine the safety and immunogenicity of live vaccines in pediatric liver and kidney transplant recipients.Design, Setting, and ParticipantsThis cohort study included select pediatr

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CHAO, D. Y., Y. Z. CHIEN, Y. P. YEH, P. S. HSU, and I. B. LIAN. "The incidence of varicella and herpes zoster in Taiwan during a period of increasing varicella vaccine coverage, 2000–2008." Epidemiology and Infection 140, no. 6 (2011): 1131–40. http://dx.doi.org/10.1017/s0950268811001786.

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SUMMARYThe introduction and the widespread use of the varicella vaccine in Taiwan has led to a 75–80% decrease in the incidence of varicella in children. However the vaccine's long-term impact on the incidence of herpes zoster (HZ) has attracted attention. By controlling gender, underlying diseases, and age effects, a Poisson regression was applied on the 2000–2008 chart records of 240 000 randomly selected residents who enrolled in the Universal National Health Insurance. The results show that, as the vaccine coverage in children increases, the incidence of varicella decreases. However, the i

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Meyer, Christine, Flora Engelmann, Nicole Arnold, et al. "Abortive Intrabronchial Infection of Rhesus Macaques with Varicella-Zoster Virus Provides Partial Protection against Simian Varicella Virus Challenge." Journal of Virology 89, no. 3 (2014): 1781–93. http://dx.doi.org/10.1128/jvi.03124-14.

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ABSTRACTVaricella-zoster virus (VZV) is a human neurotropic alphaherpesvirus and the etiological agent of varicella (chickenpox) and herpes zoster (HZ, shingles). Previously, inoculation of monkeys via the subcutaneous, intratracheal, intravenous, or oral-nasal-conjunctival routes did not recapitulate all the hallmarks of VZV infection, including varicella, immunity, latency, and reactivation. Intrabronchial inoculation of rhesus macaques (RMs) with simian varicella virus (SVV), a homolog of VZV, recapitulates virologic and immunologic hallmarks of VZV infection in humans. Given that VZV is ac

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Ass, Teresa Jackowska, Robert Wasilewski, Elzbieta Górska, Maria Wasik, and Teresa Loch. "Varicella Vaccine (VarilRix) in Children with Acute Lymphoblastic Leukemia." Blood 104, no. 11 (2004): 4436. http://dx.doi.org/10.1182/blood.v104.11.4436.4436.

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Abstract Background: To assess the effectiveness of vaccination against varicella in children with acute lymphoblastic leukemia (ALL). Methods: 105 children without a history of varicella, were qualified for immunization against varicella with VARILRIX (Oka-strain varicella vaccine). 48 children had ALL and 57 were healthy. 25 of the children with ALL were receiving maintenance therapy, 23 children were after chemotherapy. Results: White blood cells (WBC), lymphocytes, and sub-populations of T- and B-lymphocytes were compared in the healthy and leukemic children before and after vaccination. T

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Victoria, Joseph G., Chunlin Wang, Morris S. Jones, et al. "Viral Nucleic Acids in Live-Attenuated Vaccines: Detection of Minority Variants and an Adventitious Virus." Journal of Virology 84, no. 12 (2010): 6033–40. http://dx.doi.org/10.1128/jvi.02690-09.

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ABSTRACT Metagenomics and a panmicrobial microarray were used to examine eight live-attenuated viral vaccines. Viral nucleic acids in trivalent oral poliovirus (OPV), rubella, measles, yellow fever, varicella-zoster, multivalent measles/mumps/rubella, and two rotavirus live vaccines were partially purified, randomly amplified, and pyrosequenced. Over half a million sequence reads were generated covering from 20 to 99% of the attenuated viral genomes at depths reaching up to 8,000 reads per nucleotides. Mutations and minority variants, relative to vaccine strains, not known to affect attenuatio

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Hartley, Christopher, Priscila Villalba Davila, Emma Cole, and Wikrom Karnsakul. "Varicella and Zoster Vaccination Strategies in Immunosuppressed Pediatric Transplant Recipients." Vaccines 13, no. 5 (2025): 534. https://doi.org/10.3390/vaccines13050534.

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The varicella vaccine has prevented varicella in hundreds of thousands of patients since its establishment in 1974. It stimulates both humoral and cell-mediated immunity to produce an immune response that helps protect against the disease (not necessarily the infection). Serious sequala of varicella including pneumonia, hepatitis, and encephalitis can occur, with higher incidence in immunosuppressed individuals than in the general population. Patients who are not immunosuppressed should receive routine varicella vaccinations. For those who have not completed the series or are significantly dis

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Parraga, Tommy J., Jennifer McCorquodale, Sage Greenlee, et al. "1377. Impact of Pre-Transplant Infectious Diseases Wellness Visit on Vaccine Uptake in Solid Organ Transplant Candidates." Open Forum Infectious Diseases 8, Supplement_1 (2021): S774—S775. http://dx.doi.org/10.1093/ofid/ofab466.1569.

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Abstract Background Despite published guidelines, vaccine uptake in solid organ transplant candidates (SOTc) remains suboptimal. We established an Infectious Disease pre-transplant clinic (IDPT) to perform a wellness visit for all SOTc. The visit was conducted by a nurse practitioner (NP) primarily and included pre-transplant assessment and optimization of vaccinations. We report the preliminary results of this pilot project on vaccine uptake in SOTc. Methods Retrospective review was done on all SOTc referred to the IDPT from January 2020 to February 2021 at Henry Ford Transplant Institute in

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Garnett, G. P., and B. T. Grenfell. "The epidemiology of varicella–zoster virus infections: the influence of varicella on the prevalence of herpes zoster." Epidemiology and Infection 108, no. 3 (1992): 513–28. http://dx.doi.org/10.1017/s0950268800050019.

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SUMMARYThis paper uses mathematical models and data analysis to examine the epidemiological implications of possible immunologically mediated links between patterns of varicella and herpes-zoster incidence in human communities. A review of previously published reports does not clarify whether or not there is a relationship between the incidence of varicella and the incidence of zoster. However, new analysis of data collected by the Royal College of General Practitioners provides indirect evidence for the hypothesis that a high intensity of varicella transmission suppresses viral reactivation.

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Arnheim-Dahlström, Lisen, Natalie Zarabi, Karin Hagen, and Goran Bencina. "Parental acceptance and knowledge of varicella vaccination in relation to socioeconomics in Sweden: A cross-sectional study." PLOS ONE 16, no. 10 (2021): e0256642. http://dx.doi.org/10.1371/journal.pone.0256642.

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Varicella infection is a highly contagious disease which, whilst mild in most cases, can cause severe complications. Varicella vaccination is available privately in Sweden and is currently being reviewed for inclusion in the Swedish Public Health Agency’s national immunisation program (NIP). A cross-sectional study of parents of Swedish children aged 1–8 years (n = 2212) was conducted to understand parental acceptance, beliefs and knowledge around varicella infection and vaccination. Respondents generally viewed varicella infection as a mild disease, with only a small proportion aware of poten

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Simon, Susanne, Oana Joean, Tobias Welte, and Jessica Rademacher. "The role of vaccination in COPD: influenza, SARS-CoV-2, pneumococcus, pertussis, RSV and varicella zoster virus." European Respiratory Review 32, no. 169 (2023): 230034. http://dx.doi.org/10.1183/16000617.0034-2023.

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Exacerbations of COPD are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression and death. At least 70% of COPD exacerbations are infectious in origin, with respiratory viruses identified in approximately 30% of cases. Despite long-standing recommendations to vaccinate patients with COPD, vaccination rates remain suboptimal in this population.Streptococcus pneumoniaeis one of the leading morbidity and mortality causes of lower respiratory tract infections. The Food and Drug Administration recently approved pneumococcal conjugate vac

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Tao-Kidoguchi, Chiaki, Takanori Funaki, Kensuke Shoji, et al. "#62: Safety of Live Attenuated Vaccines Administered after Pediatric Liver Transplantation." Journal of the Pediatric Infectious Diseases Society 10, Supplement_1 (2021): S1—S2. http://dx.doi.org/10.1093/jpids/piaa170.003.

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Abstract Background Live attenuated vaccines (LAVs) are currently contraindicated in immunocompromised patients such as solid-organ transplant (SOT) recipients. The guideline published by the Infectious Disease Society of America also cautions that LAVs after SOT are contraindicated. However, several articles have demonstrated that these patients may receive LAVs safely by adhering to a protocol consisting of an evaluation of many immunological parameters. The aim of this study was to evaluate the safety of LAVs, including measles, mumps, rubella, and varicella to liver transplant (LT) recipie

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Kang, Hyun Mi, Gwanglok Kim, and Young June Choe. "Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in Children." Vaccines 11, no. 9 (2023): 1442. http://dx.doi.org/10.3390/vaccines11091442.

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Two live attenuated varicella vaccine (VZV) strains have been mainly used across the globe: MAV/06 and OKA strains. We aimed to explore the safety of interchanging the two VZV strains for primary and booster immunizations. South Korea’s vaccine adverse event reporting system (VAERS) was accessed and searched to find filed reports of all adverse events (AEs) following immunization with the second dose of the varicella vaccine. The electronic medical records were reviewed for all visits to the hospital following the second dose of the varicella vaccine. Of the total 406 study participants, 27.5%

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Rahman, Md Mizanur, and Kanij Fatema. "Risk of Seizures after Immunization with Vaccine in Children." Bangladesh Journal of Child Health 44, no. 1 (2020): 40–47. http://dx.doi.org/10.3329/bjch.v44i1.49697.

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Adverse neurological event particularly seizure after vaccination is not uncommon. The most linked vaccines are Diphtheria, Pertussis and Tetanus toxoid (DPT), Measles, Mumps and Rubella (MMR) and other combination vaccines. It is documented that increased febrile seizure after DPT and MMR vaccine is due to increase febrile episodes precipitating seizure and it is time related. Concomitant administration of vaccines cause seizure due to synergistic effect of those vaccines. When these vaccines are given separately, the risk of seizure is decreased. These type of vaccines are MMR + varicella (M

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Gershon, Anne A., David Brooks, Donald D. Stevenson, William K. Chin, Michael B. A. Oldstone, and Michael D. Gershon. "High Constitutive Interleukin 10 Level Interferes With the Immune Response to Varicella-Zoster Virus in Elderly Recipients of Live Attenuated Zoster Vaccine." Journal of Infectious Diseases 219, no. 8 (2018): 1338–46. http://dx.doi.org/10.1093/infdis/jiy660.

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Abstract Introduction Live attenuated zoster vaccine (Zostavax) was used to test the hypothesis that constitutive level of interleukin 10 (IL-10), which may be high in elderly subjects, impairs vaccine efficacy. If constitutive IL-10 impairs vaccine efficacy, the effectiveness of viral vaccines might be improved by transient inhibition of IL-10 before vaccination. Methods Zostavax was given to 26 patients (age, 60–80 years). IL-10 and immunity to varicella zoster virus (VZV) were measured at baseline and after vaccination. Fluorescent antibody to membrane antigen (FAMA) assays and glycoprotein

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Hull, Brynley, Aditi Dey, Rob Menzies, and Peter McIntyre. "Annual Immunisation Coverage Report, 2010." Communicable Diseases Intelligence 37 (March 1, 2013): 21–39. https://doi.org/10.33321/cdi.2013.37.2.

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Published erratum: Commun Dis Intell 2013;37(2):193–195 Tables 2, 3 and 4 had incorrect state and territory headings for the data. The tables have been corrected in the erratum. This, the fourth annual immunisation coverage report, documents trends during 2010 for a range of standard measures derived from Australian Childhood Immunisation Register (ACIR) data. These include coverage at standard age milestones and for individual vaccines included on the National Immunisation Program (NIP). For the first time, coverage from other sources for adolescents and the elderly are included.The proportio

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Harris, T., CY Seo, E. Shing, K. Wong, J. Fediurek, and SL Deeks. "Un petit souci : Pourquoi les programmes d’immunisation contre la varicelle sont importants." Relevé des maladies transmissibles au Canada 41, no. 10 (2015): 275–84. http://dx.doi.org/10.14745/ccdr.v41i10a04f.

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Duncan, Deborah Louise. "Chickenpox: Presentation, transmission, complications and prevention." British Journal of School Nursing 14, no. 10 (2019): 482–85. http://dx.doi.org/10.12968/bjsn.2019.14.10.482.

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Varicella, commonly known as chickenpox is an acute and highly infectious disease, which is caused by the varicella zoster virus Varicella. The two chickenpox vaccines available in the UK are Varilrix and Varivax but are not included in the routine childhood vaccination scheme unless they are immunocompromised ( Gov.uk, 2018 ; PHE, 2019 ). The varicella vaccination has been associated with a dramatic reduction in chickenpox cases in countries such as the United States, where every child can be vaccinated ( Seward et al, 2002 ). Johnston et al (1997) ; however, suggest that approximately 2–3% o

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Lavin, Arthur. "Varicella Vaccine." Pediatrics 104, no. 1 (1999): 132.2–132. http://dx.doi.org/10.1542/peds.104.1.132-a.

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&NA;. "Varicella vaccine." Reactions Weekly &NA;, no. 386 (1992): 12. http://dx.doi.org/10.2165/00128415-199203860-00060.

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&NA;. "Varicella vaccine." Reactions Weekly &NA;, no. 937 (2003): 15. http://dx.doi.org/10.2165/00128415-200309370-00067.

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PLOTKIN, STANLEY A. "Varicella Vaccine." Pediatrics 97, no. 2 (1996): 251–53. http://dx.doi.org/10.1542/peds.97.2.251.

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The development and licensing of a vaccine for varicella in the United States has taken an incredible length of time. From the first report by Takahashi et al in 1974 until final American licensure in 1995, extensive studies were conducted by many investigators. Despite this long gestation period, which could have produced an elephant, there is some danger that the result will be a mouse, in that use of the vaccine since licensure has been far from universal. Recommendations by the American Academy of Pediatrics' Red Book Commitee and the Advisory Committee on Immunization Practices (statement

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