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Relevant bibliographies by topics / Varicocele, cytokines, sperm DNA damage

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Journal articles

Academic literature on the topic 'Varicocele, cytokines, sperm DNA damage'

Author: Grafiati

Published: 22 February 2023

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Journal articles on the topic "Varicocele, cytokines, sperm DNA damage"

1

Poli, Giulia, Consuelo Fabi, Chiara Sugoni, et al. "The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility." International Journal of Molecular Sciences 23, no. 9 (2022): 5233. http://dx.doi.org/10.3390/ijms23095233.

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Varicocele (VC) is the most common abnormality identified in men evaluated for hypofertility. Increased levels of reactive oxygen species (ROS) and reduced antioxidants concentrations are key contributors in varicocele-mediated hypofertility. Moreover, inflammation and alterations in testicular immunity negatively impact male fertility. In particular, NLRP3 inflammasome activation was hypothesized to lead to seminal inflammation, in which the levels of specific cytokines, such as IL-1β and IL-18, are overexpressed. In this review, we described the role played by oxidative stress (OS), inflamma

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2

Hewedy, El-Sayed S., Desouky E. Abou Ammo, Tarek E. Amin, et al. "Sperm DNA damage in varicocele patients." Human Andrology 2, no. 3 (2012): 70–74. http://dx.doi.org/10.1097/01.xha.0000417808.08428.f2.

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3

Peluso, Giuseppina, Alessandro Palmieri, Pietro Paolo Cozza, et al. "The study of spermatic DNA fragmentation and sperm motility in infertile subjects." Archivio Italiano di Urologia e Andrologia 85, no. 1 (2013): 8. http://dx.doi.org/10.4081/aiua.2013.1.8.

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Introduction: Although the pathophysiology of the testicular damage associated with varicocele remains unclear, sperm DNA damage has been identified as a potential explanation for this cause of male infertility. The current study was designed to determine the extent of sperm nuclear DNA damage in patients with varicocele, and to examine its relationship with parameters of seminal motility. Materials and method: Semen samples from 60 patients with clinical varicocele and 90 infertile men without varicocele were examined. Varicocele sperm samples were classified as normal or pathological accordi

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4

Kadioglu, Teoman Cem, Emin Aliyev, and Murad Celtik. "Microscopic Varicocelectomy Significantly Decreases the Sperm DNA Fragmentation Index in Patients with Infertility." BioMed Research International 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/695713.

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Background. Varicocele is associated with high levels of DNA damage in spermatozoa due to oxidative stress and elevated levels of sperm DNA fragmentation, which has been currently proposed to be an essential additional diagnostic test to be recommended for patients with clinical varicocele. The aim of this study was to evaluate the parameters of semen and the DNA fragmentation index (DFI) in patients with varicocele before and after varicocelectomy.Methods. The details of 92 consecutive patients were retrospectively analyzed from January 2010 to December 2012. The sperm samples were evaluated

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5

Mongioì, Laura Maria, Angela Alamo, Aldo E. Calogero, et al. "Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele." International Journal of Immunopathology and Pharmacology 34 (January 2020): 205873842092571. http://dx.doi.org/10.1177/2058738420925719.

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Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm analysis was conducted according to the World Health Organization (WHO) 2010 criteria. We evaluated seminal leukocyte subpopulations and bio-functional sperm parameters by flow cytometry. Patients with varicocele had significantly lower sperm concentration and total number than contro

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6

Mohammed, Essam-Elden M., Eman Mosad, Asmaa M. Zahran, Diaa A. Hameed, Emad A. Taha, and Mohamed A. Mohamed. "Acridine Orange and Flow Cytometry: Which Is Better to Measure the Effect of Varicocele on Sperm DNA Integrity?" Advances in Urology 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/814150.

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We evaluated the effect of varicocelectomy on semen parameters and levels of sperm DNA damage in infertile men. A total of 75 infertile men with varicocele and 40 fertile men (controls) were included in this study. Semen analysis and sperm DNA damage expressed as the DNA fragmentation index using acridine orange staining and chromatin condensation test by flow cytometry were assessed before and 6 months after varicocelectomy. The patients were also followed up for 1 year for pregnancy outcome. Semen parameters were significantly lower in varicocele patients compared to controls (P<0.05). Me

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7

SULAIMAN ABDULKAREEM, ABDULGHAFOOR, HISHYAR AZO, and AHMED TAHIR RAJAB. "SPERM DNA DAMAGE RATE AMONG INFERTILE PATIENTS WITH VARICOCELE." Duhok Medical Journal 16, no. 2 (2022): 93–103. http://dx.doi.org/10.31386/dmj.2022.16.2.9.

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8

Bahreinian, Mahsa, Marziyeh Tavalaee, Homayon Abbasi, Abbas Kiani-Esfahani, Abdol Hossein Shiravi, and Mohammad H. Nasr-Esfahani. "DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele." Systems Biology in Reproductive Medicine 61, no. 4 (2015): 179–86. http://dx.doi.org/10.3109/19396368.2015.1020116.

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9

Tang, Li-Xin, Dong-Juan Yuan, Qi-Ling Wang, et al. "Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study." Reproduction, Fertility and Development 28, no. 5 (2016): 648. http://dx.doi.org/10.1071/rd14276.

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Varicocele is commonly associated with male infertility because it impairs normal sperm morphology and activity. Polyunsaturated fatty acids (PUFA) are important determinants of sperm cell structure and function, but their relationship with varicocele remains unclear. The aim of the present study was to investigate the PUFA composition in spermatozoa of infertile men with varicocele and to evaluate the potential relationship between PUFA and varicocele. This case control study recruited 92 infertile men with varicocele, 99 infertile men without varicocele and 95 fertile male control subjects.

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10

Missassi, Gabriela, Cibele dos Santos Borges, Josiane de Lima Rosa, et al. "Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/2172981.

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Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and spe

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