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Journal articles on the topic 'Varicocele, cytokines, sperm DNA damage'

Author: Grafiati

Published: 22 February 2023

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1

Poli, Giulia, Consuelo Fabi, Chiara Sugoni, et al. "The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility." International Journal of Molecular Sciences 23, no. 9 (2022): 5233. http://dx.doi.org/10.3390/ijms23095233.

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Varicocele (VC) is the most common abnormality identified in men evaluated for hypofertility. Increased levels of reactive oxygen species (ROS) and reduced antioxidants concentrations are key contributors in varicocele-mediated hypofertility. Moreover, inflammation and alterations in testicular immunity negatively impact male fertility. In particular, NLRP3 inflammasome activation was hypothesized to lead to seminal inflammation, in which the levels of specific cytokines, such as IL-1β and IL-18, are overexpressed. In this review, we described the role played by oxidative stress (OS), inflamma

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Hewedy, El-Sayed S., Desouky E. Abou Ammo, Tarek E. Amin, et al. "Sperm DNA damage in varicocele patients." Human Andrology 2, no. 3 (2012): 70–74. http://dx.doi.org/10.1097/01.xha.0000417808.08428.f2.

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Peluso, Giuseppina, Alessandro Palmieri, Pietro Paolo Cozza, et al. "The study of spermatic DNA fragmentation and sperm motility in infertile subjects." Archivio Italiano di Urologia e Andrologia 85, no. 1 (2013): 8. http://dx.doi.org/10.4081/aiua.2013.1.8.

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Introduction: Although the pathophysiology of the testicular damage associated with varicocele remains unclear, sperm DNA damage has been identified as a potential explanation for this cause of male infertility. The current study was designed to determine the extent of sperm nuclear DNA damage in patients with varicocele, and to examine its relationship with parameters of seminal motility. Materials and method: Semen samples from 60 patients with clinical varicocele and 90 infertile men without varicocele were examined. Varicocele sperm samples were classified as normal or pathological accordi

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Kadioglu, Teoman Cem, Emin Aliyev, and Murad Celtik. "Microscopic Varicocelectomy Significantly Decreases the Sperm DNA Fragmentation Index in Patients with Infertility." BioMed Research International 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/695713.

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Background. Varicocele is associated with high levels of DNA damage in spermatozoa due to oxidative stress and elevated levels of sperm DNA fragmentation, which has been currently proposed to be an essential additional diagnostic test to be recommended for patients with clinical varicocele. The aim of this study was to evaluate the parameters of semen and the DNA fragmentation index (DFI) in patients with varicocele before and after varicocelectomy.Methods. The details of 92 consecutive patients were retrospectively analyzed from January 2010 to December 2012. The sperm samples were evaluated

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Mongioì, Laura Maria, Angela Alamo, Aldo E. Calogero, et al. "Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele." International Journal of Immunopathology and Pharmacology 34 (January 2020): 205873842092571. http://dx.doi.org/10.1177/2058738420925719.

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Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm analysis was conducted according to the World Health Organization (WHO) 2010 criteria. We evaluated seminal leukocyte subpopulations and bio-functional sperm parameters by flow cytometry. Patients with varicocele had significantly lower sperm concentration and total number than contro

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Mohammed, Essam-Elden M., Eman Mosad, Asmaa M. Zahran, Diaa A. Hameed, Emad A. Taha, and Mohamed A. Mohamed. "Acridine Orange and Flow Cytometry: Which Is Better to Measure the Effect of Varicocele on Sperm DNA Integrity?" Advances in Urology 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/814150.

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We evaluated the effect of varicocelectomy on semen parameters and levels of sperm DNA damage in infertile men. A total of 75 infertile men with varicocele and 40 fertile men (controls) were included in this study. Semen analysis and sperm DNA damage expressed as the DNA fragmentation index using acridine orange staining and chromatin condensation test by flow cytometry were assessed before and 6 months after varicocelectomy. The patients were also followed up for 1 year for pregnancy outcome. Semen parameters were significantly lower in varicocele patients compared to controls (P<0.05). Me

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SULAIMAN ABDULKAREEM, ABDULGHAFOOR, HISHYAR AZO, and AHMED TAHIR RAJAB. "SPERM DNA DAMAGE RATE AMONG INFERTILE PATIENTS WITH VARICOCELE." Duhok Medical Journal 16, no. 2 (2022): 93–103. http://dx.doi.org/10.31386/dmj.2022.16.2.9.

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Bahreinian, Mahsa, Marziyeh Tavalaee, Homayon Abbasi, Abbas Kiani-Esfahani, Abdol Hossein Shiravi, and Mohammad H. Nasr-Esfahani. "DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele." Systems Biology in Reproductive Medicine 61, no. 4 (2015): 179–86. http://dx.doi.org/10.3109/19396368.2015.1020116.

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9

Tang, Li-Xin, Dong-Juan Yuan, Qi-Ling Wang, et al. "Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study." Reproduction, Fertility and Development 28, no. 5 (2016): 648. http://dx.doi.org/10.1071/rd14276.

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Varicocele is commonly associated with male infertility because it impairs normal sperm morphology and activity. Polyunsaturated fatty acids (PUFA) are important determinants of sperm cell structure and function, but their relationship with varicocele remains unclear. The aim of the present study was to investigate the PUFA composition in spermatozoa of infertile men with varicocele and to evaluate the potential relationship between PUFA and varicocele. This case control study recruited 92 infertile men with varicocele, 99 infertile men without varicocele and 95 fertile male control subjects.

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Missassi, Gabriela, Cibele dos Santos Borges, Josiane de Lima Rosa, et al. "Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/2172981.

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Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and spe

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Sadeghi, Niloofar, Naeem Erfani-Majd, Marziyeh Tavalaee, Mohammad R. Tabandeh, Joël R. Drevet, and Mohammad H. Nasr-Esfahani. "Signs of ROS-Associated Autophagy in Testis and Sperm in a Rat Model of Varicocele." Oxidative Medicine and Cellular Longevity 2020 (April 13, 2020): 1–11. http://dx.doi.org/10.1155/2020/5140383.

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Since autophagy was suspected to occur in the pathological situation of varicocele (VCL), we have attempted to confirm it here using a surgical model of varicocele-induced rats. Thirty Wistar rats were divided into three groups (varicocele/sham/control) and analyzed two months after the induction of varicocele. Testicular tissue sections and epididymal mature sperm were then monitored for classic features of varicocele, including disturbance of spermatogenesis, impaired testicular carbohydrate and lipid homeostasis, decreased sperm count, increased sperm nuclear immaturity and DNA damage, oxid

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Mendes, Talita Biude, Camila Cicconi Paccola, Flávia Macedo de Oliveira Neves, et al. "Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty." Reproduction 152, no. 1 (2016): 23–35. http://dx.doi.org/10.1530/rep-16-0025.

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The aim of this study was to investigate the protective action of resveratrol against the reproductive damage caused by left-sided experimental varicocele. There was a reduction of testicular major axis in the varicocele group when compared with the other groups; the testicular volume was reduced in varicocele group in comparison to the sham–control and resveratrol groups. The frequency of morphologically abnormal sperm was higher in varicocele and varicocele treated with resveratrol groups than in sham–control and resveratrol groups. The frequency of sperm with 100% of mitochondrial activity

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Wang, Ying-Jun, Rong-Qiu Zhang, Yan-Jun Lin, Rong-Gui Zhang, and Wei-Li Zhang. "Relationship between varicocele and sperm DNA damage and the effect of varicocele repair: a meta-analysis." Reproductive BioMedicine Online 25, no. 3 (2012): 307–14. http://dx.doi.org/10.1016/j.rbmo.2012.05.002.

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Panner Selvam, Manesh Kumar, Luna Samanta, and Ashok Agarwal. "Functional Analysis of Differentially Expressed Acetylated Spermatozoal Proteins in Infertile Men with Unilateral and Bilateral Varicocele." International Journal of Molecular Sciences 21, no. 9 (2020): 3155. http://dx.doi.org/10.3390/ijms21093155.

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Sperm proteins undergo post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, which in turn play a key role in determining their fertilizing ability. In the current study, we examined the sperm proteome of men with unilateral and bilateral varicocele to identify the key proteins affected by acetylation to gain an insight into the difference in the severity of affected sperm function in the latter. An LTQ-Orbitrap Elite hybrid mass spectrometer system was used to profile the sperm proteome in pooled unilateral and bilateral varicocele patients. Bioinformatic

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Siam, Emad Mustafa, Mohamed Tawfeek, and Momen Hassan. "RETRACTED ARTICLE: Sperm DNA damage due to the oxidative stress associated with varicocele." Journal of Assisted Reproduction and Genetics 36, no. 6 (2011): 1295. http://dx.doi.org/10.1007/s10815-010-9532-2.

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Smith, R., H. Kaune, D. Parodi, et al. "Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress." Human Reproduction 21, no. 4 (2005): 986–93. http://dx.doi.org/10.1093/humrep/dei429.

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17

Rahmani, M., M. Tavalaee, M. Hosseini, et al. "Deferasirox, an Iron-Chelating Agent, Improves Testicular Morphometric and Sperm Functional Parameters in a Rat Model of Varicocele." Oxidative Medicine and Cellular Longevity 2021 (April 8, 2021): 1–17. http://dx.doi.org/10.1155/2021/6698482.

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Varicocele is characterized by testicular dysfunction that originates from hyperthermia and hypoxia, leading to defects in testicular tissue and altered spermatozoa structure and function. The varicocele testis is characterized by the presence of intracellular iron deposits that contribute to the associated oxidative stress. Therefore, we tested the hypothesis that administration of an iron-chelating agent, such as deferasirox (DFX), could potentially mitigate the consequences of varicocele on testicular tissue and spermatozoa. Using a well-established rat model of varicocele (VCL), we show th

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Fraczek, Monika, Angelika Lewandowska, Marta Budzinska, et al. "The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress." International Journal of Environmental Research and Public Health 19, no. 5 (2022): 2713. http://dx.doi.org/10.3390/ijerph19052713.

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Responding to the need for the verification of some experimental animal studies showing the involvement of oxidative stress in germ cell damage in the heat-induced testis, we investigated the possibility of a direct relationship between seminal oxidative stress markers (total antioxidant capacity, catalase activity, superoxide dismutase activity, and malondialdehyde concentration) and ejaculated sperm chromatin/DNA integrity (DNA fragmentation and chromatin condensation abnormalities) in distinct groups of men exposed and not exposed to prolonged scrotal hyperthermia. A statistical increase in

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Basioura, Athina, Georgia D. Brellou, Ioannis Tsakmakidis, Ioannis Vlemmas, Constantin M. Boscos, and Nektarios Giadinis. "Varicocele in an Adult Ram: Histopathological Examination and Sperm Quality Evaluation." Veterinary Sciences 9, no. 2 (2022): 86. http://dx.doi.org/10.3390/vetsci9020086.

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Varicocele is a common pathological condition of testis that is related to male fertility problems. A 3-year age Chios ram had an abnormally enlarged scrotal area, was excluded from reproductive duties, and was euthanized with the owners’ permission. The main pathological finding was the presence of bilateral multinodular spermatic cord enlargement with laminated vascular thrombi. Histopathological examination revealed commonly mineralized thrombi within the lumen of veins of the pampiniform plexus, inflammation and testicular degeneration. The epididymides were transported to the laboratory a

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Öztürk, M. I., O. Koca, M. O. Keles, S. Yilmaz, and M. I. Karaman. "S56 INCREASED SPERM DNA DAMAGE IN EXPERIMENTAL RAT VARICOCELE MODEL AND BENEFICIAL EFFECT OF VARICOCELECTOMY." European Urology Supplements 11, no. 4 (2012): 146. http://dx.doi.org/10.1016/s1569-9056(13)60250-x.

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21

Saleh, Ramadan A., Ashok Agarwal, Anthony J. Thomas, Rakesh K. Sharma, David R. Nelson, and Donald P. Evenson. "Varicocele in infertile men is significantly correlated with increased levels of sperm nuclear DNA damage." Fertility and Sterility 78 (September 2002): S259. http://dx.doi.org/10.1016/s0015-0282(02)04116-x.

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22

Tiseo, BC, E. Bonfá, EF Borba, et al. "Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients." Lupus 28, no. 1 (2018): 59–65. http://dx.doi.org/10.1177/0961203318815764.

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Objective To evaluate sperm DNA fragmentation analysis in non-azoospermic male systemic lupus erythematosus (SLE) patients. Methods Twenty-eight consecutive male SLE patients (American College of Rheumatology criteria) and 34 healthy controls were evaluated for demographic/exposures data, urological evaluation, hormone profile and sperm analysis (including sperm DNA fragmentation). Clinical features, disease activity/damage scores and treatment were also evaluated. Results The median age (33 (20–52) vs. 36.5 (25–54) years, P = 0.329) and frequency of varicocele (25% vs. 32%, P = 0.183) were si

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Cortés-Gutiérrez, Elva I., Martha I. Dávila-Rodríguez, José Luis Fernández, et al. "DNA damage in spermatozoa from infertile men with varicocele evaluated by sperm chromatin dispersion and DBD-FISH." Archives of Gynecology and Obstetrics 293, no. 1 (2015): 189–96. http://dx.doi.org/10.1007/s00404-015-3822-y.

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Aitken, R. J. "001. ORIGINS OF DNA DAMAGE IN SPERMATOZOA." Reproduction, Fertility and Development 22, no. 9 (2010): 1. http://dx.doi.org/10.1071/srb10abs001.

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DNA damage is frequently encountered in the spermatozoa of sub-fertile male mammals and is correlated with a range of adverse clinical outcomes including impaired fertilization, disrupted embryonic development, increased rates of miscarriage and an enhanced risk of disease in the progeny. The etiology of DNA fragmentation in human spermatozoa is closely correlated with the appearance of oxidative base adducts and evidence of impaired chromatin remodelling during spermiogenesis. In light of these associations we propose a two step hypothesis for the origins of DNA damage in spermatozoa. In Step

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Kowalczyk, Alicja. "The Role of the Natural Antioxidant Mechanism in Sperm Cells." Reproductive Sciences 29, no. 5 (2021): 1387–94. http://dx.doi.org/10.1007/s43032-021-00795-w.

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AbstractMolecular studies of the causes of male infertility revealed a significant contribution of oxidative stress. When excessive amounts of reactive oxygen species (ROS) are produced or antioxidant activity fails, the equilibrium between oxidation and reduction is disrupted, causing oxidative stress (OS). High levels of ROS can have an adverse effect on sperm function through the initiation of DNA damage, lipid peroxidation, loss of membrane integrity and increased permeability, inactivation of cellular enzymes, and cell apoptosis. In addition to endogenous factors such as immature sperm, l

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Tvrdá, Eva, Michal Ďuračka, Filip Benko, et al. "Ejaculatory Abstinence Affects the Sperm Quality in Normozoospermic Men—How Does the Seminal Bacteriome Respond?" International Journal of Molecular Sciences 24, no. 4 (2023): 3503. http://dx.doi.org/10.3390/ijms24043503.

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This study was designed to describe bacterial profiles of ejaculates collected following a long and short ejaculatory abstinence set in the context of changes in the conventional, oxidative, and immunological characteristics of semen. Two specimens were collected in succession from normozoospermic men (n = 51) following 2 days and 2 h, respectively. Semen samples were processed and analyzed according to the World Health Organization (WHO) 2021 guidelines. Afterwards, sperm DNA fragmentation, mitochondrial function, levels of reactive oxygen species (ROS), total antioxidant capacity, and oxidat

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Delle Fave, Rocco Francesco, Giordano Polisini, Gianluca Giglioni, Arnaldo Parlavecchio, Lucio Dell'Atti, and Andrea Benedetto Galosi. "COVID-19 and male fertility: Taking stock of one year after the outbreak began." Archivio Italiano di Urologia e Andrologia 93, no. 1 (2021): 115–19. http://dx.doi.org/10.4081/aiua.2021.1.115.

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Objectives: The aim of this review is to summarize, following a timeline, the current knowledge regarding the effects of the Sars-cov2 virus on male fertility, researching the pathological and clinical results of the studies published in the last year. Methods: A systematic research was performed on the major international online databases; Thirty-five articles were selected. Results: A statistically significant reduction in testosterone levels and sperm quality in subjects with COVID-19 has been highlighted in several papers; however, in many cases the tests have been conducted in patients wi

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Sancler-Silva, Y. F. R., G. A. Monteiro, F. S. Ignacio, F. P. Hartwig, and F. O. Papa. "161 PROCESSING OF SEMEN WITH PYOSPERMIA ALLOWS ITS USE IN EQUINE EMBRYO TRANSFER PROGRAMS." Reproduction, Fertility and Development 25, no. 1 (2013): 229. http://dx.doi.org/10.1071/rdv25n1ab161.

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Previous studies in humans and current studies in horses show that the presence of leukocytes in the semen promotes increased reactive oxygen species and proinflammatory cytokines production. These substances cause damage to membrane integrity, mitochondrial function, DNA integrity, and lead to increased expression of apoptosis markers in the spermatic cell. As a result of these effects, decreased quality and longevity of the semen that lead to fertility reduction could be highlighted. A 6-year-old stallion was admitted in the Department of Animal Reproduction and Veterinary Radiology of Veter

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Mohammed Muhsin, Jasim, Sura O. Yousif, Ameer M. Hadi, and Mohammed Haider Hamad. "Male infertility and viral infection: Interference role of the human herpesvirus types (3 – 6) with disturbances effects of some cytokines hypersecretion and seminal oxidative defense system in the infertility etiopathogenesis of some idiopathic infertile Iraqi patients." Biomedical & Pharmacology Journal 12, no. 3 (2019): 1181–92. http://dx.doi.org/10.13005/bpj/1747.

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To study the role of potential relationship of chronic human herpes virus types (3 – 6) infection and their correlation with the up-regulation of some cytokines (IL-2, IL-10 and IFN gamma) and effect of (8-OHdG) and (TAOC) levels onto male infertility. A Case – control study with semen samples which were collected by masturbation during the routine semen analysis of a total ninety age-matched participants as; fertile males 35 (38.9%) with proven fertility as a normal semen quality and infertile males 55 (61.1%) with at least one year of infertility and poor semen quality. All semen biomarkers

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Finelli, Renata, Francesco Pallotti, Francesco Cargnelutti, et al. "Sperm DNA damage and cytokines in varicocele: A case‐control study." Andrologia 53, no. 5 (2021). http://dx.doi.org/10.1111/and.14023.

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Sen Sharma, D. "O-019 Covid 19 and male infertility-how long should fertility treatment be deferred to overcome the postcovid changes in semen parameters and to restore male fertility?" Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac104.019.

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Abstract Study question Male recovered from covid19 showed negative impact on sperm quality- are these changes reversible and are antioxidant therapy beneficial to overcome sperm quality changes? Summary answer Oxidative stress created by the proinflammatory cytokine storm by covid19 virion might interect with spermatozoa to cause changes in spermiogram and antioxidant is the treatment What is known already Covid19 virion might interect with human spermatozoa and disrupt male fertility. Suppression of semen volume, progressive motility, morphology, sperm number and DNA integrity as a result of

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Wood, Guilherme Jacom Abdulmassih, João Paulo Greco Cardoso, Davi Vischi Paluello, Thiago Fagundes Nunes, and Marcello Cocuzza. "Varicocele-Associated Infertility and the Role of Oxidative Stress on Sperm DNA Fragmentation." Frontiers in Reproductive Health 3 (October 29, 2021). http://dx.doi.org/10.3389/frph.2021.695992.

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Varicocele has been extensively described and studied as the most important reversible cause of male infertility. Its impact on semen parameters, pregnancy rates, and assisted reproductive outcomes have been associated with multifactorial aspects, most of them converging to increase of reactive oxygen species (ROS). More recently, sperm DNA fragmentation has gained significant attention and potential clinical use, although the body of evidence still needs further evolution. The associations between sperm DNA damage and a variety of disorders, including varicocele itself, share common pathways

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Finelli, Renata, Sara Darbandi, Peter Natesan Pushparaj, Ralf Henkel, Edmund Ko, and Ashok Agarwal. "In Silico Sperm Proteome Analysis to Investigate DNA Repair Mechanisms in Varicocele Patients." Frontiers in Endocrinology 12 (December 17, 2021). http://dx.doi.org/10.3389/fendo.2021.757592.

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Varicocele, a condition associated with increased oxidative stress, negatively affects sperm DNA integrity and reduces pregnancy rates. However, the molecular mechanisms related to DNA integrity, damage, and repair in varicocele patients remain unclear. This study aimed to determine the role of DNA repair molecular mechanisms in varicocele-related infertility by combining an in silico proteomics approach with wet-laboratory techniques. Proteomics results previously generated from varicocele patients (n=50) and fertile controls (n=10) attending our Andrology Center were reanalyzed using bioinfo

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Ammar, O., and M. Mehdi. "P–086 High level of sperm DNA breaks in infertile men with varicocele: its association with sperm cells death, seminal oxidative stress, and spermatic parameters." Human Reproduction 36, Supplement_1 (2021). http://dx.doi.org/10.1093/humrep/deab130.085.

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Abstract Study question Our objectives were to determine the extent of nuclear sperm injury in varicocele patients with and without altered spermatic parameters and to investigate its relationship with apoptosis and oxidative stress. Summary answer Oxidative stress (OS) in the varicocele patients may play a role in the etiology of nuclear sperm DNA damage associated with apoptosis. What is known already Varicocele is associated with high level of DNA Breaks. Study design, size, duration Ejaculated sperm samples from 51 patients diagnosed with varicocele and 29 fertile men were examined. Accord

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Boussabbeh, M., M. Ben Jmaa, A. Sallem, I. Belghaieb, O. Ammar, and M. Mehdi. "P-058 Risk factors associated with sperm DNA fragmentation in Tunisian subfertile men." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac107.054.

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Abstract Study question The aim of the study was to investigate risk factors for sperm DNA fragmentation to determine which factors influence significantly the sperm DNA fragmentation. Summary answer Obesity seems to lead to higher risk of sperm DNA damage in Tunisian subfertile men. What is known already A positive association between lifestyle conditions, varicocele, advanced age and exposure to toxicants and DNA fragmentation has been documented. Study design, size, duration It’s a retrospective case control study. 61 Patients registered from October 2018 to December 2021 were divided into

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GÖKTEPE, Özge, Fazile CANTÜRK TAN, Figen NARİN, and Birkan YAKAN. "The evaluation of sperm DNA damage in patients with different varicocele grades." Acta Medica Alanya, May 10, 2021. http://dx.doi.org/10.30565/medalanya.849413.

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Zhang, Yuyang, Wei Zhang, Xu Wu, et al. "Effect of varicocele on sperm DNA damage: A systematic review and meta‐analysis." Andrologia 54, no. 1 (2021). http://dx.doi.org/10.1111/and.14275.

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Mehdi Heidari, Mohammad, Amirhossein Danafar, Fahime Moezzi, Mehri Khatami, and Ali Reza Talebi. "The association between TNP2 gene polymorphisms and Iranian infertile men with varicocele: A case-control study." International Journal of Reproductive BioMedicine, September 3, 2019. http://dx.doi.org/10.18502/ijrm.v17i8.4821.

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Background: Numerous researches have provided great evidence that revealed the relationship between varicocele and sperm DNA damage. Objective: Because of the crucial role of nuclear transition proteins (TPs) in sperm DNA condensation and integrity, this case-control study was designed to study TNP2 gene nucleotide variations in Iranian patients with varicocele. Materials and Methods: PCR-SSCP and DNA sequencing were used to search for mutations in exons 1 & 2 of the TNP2 gene in 156 infertile patients with varicocele and 150 fertile men. Results: The results of sequencin

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Napolitano, Luigi, Savio Domenico Pandolfo, Achille Aveta, et al. "The Management of Clinical Varicocele: Robotic Surgery Approach." Frontiers in Reproductive Health 4 (March 22, 2022). http://dx.doi.org/10.3389/frph.2022.791330.

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Varicocele is a pathologic dilation of the testicular veins within the spermatic cord. Varicocele is considered the most common problem in reproductive medicine practice. It is identified in 15% of healthy men and up to 35% of men with primary infertility. The exact pathophysiology of varicoceles is not very well understood, and several theories have been proposed to explain it. Varicocele can impair sperm quality and fertility via various mechanisms: reflux of adrenal metabolites, increased testicular hypoxia, oxidative stress, and increased testicular temperature have been proposed. Several

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Tenori. Lir. Neto, F., M. Roque, and S. Esteves. "P–004 Effect of varicocelectomy on sperm DNA fragmentation rates in infertile men with clinical varicocele: a systematic review and meta-analysis." Human Reproduction 36, Supplement_1 (2021). http://dx.doi.org/10.1093/humrep/deab130.003.

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Abstract Study question Does varicocelectomy improve sperm DNA quality in men with infertility and clinically detected varicoceles? Summary answer Varicocelectomy reduces sperm DNA fragmentation (SDF) rates in infertile men with clinical varicocele. What is known already Varicocele has been linked to male infertility through various non-mutually exclusive mechanisms, including an increase in reactive oxygen species (ROS) production that may lead to sperm DNA damage. Damage to sperm DNA may result in longer time-to-pregnancy, unexplained infertility, recurrent pregnancy loss, and failed intraut

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Bozhedomov, V., A. Shomarufov, G. Bozhedomova, D. Kamalov, N. Sorokin, and A. Kamalov. "P–101 Comparative assessment of laparoscopic, microsurgical varicocelectomy, and antioxidant therapy alone in Infertile men with pathozoospermia." Human Reproduction 36, Supplement_1 (2021). http://dx.doi.org/10.1093/humrep/deab130.100.

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Abstract Study question Which treatment option is better in men with clinical varicocele and pathozoospermia: laparoscopic, microsurgical varicocelectomy, or antioxidant (nutrient) therapy alone? Summary answer Microsurgical varicocelectomy and laparoscopy are more effective in pathozoospermia treatment than observation and nutrient therapy alone. Simultaneously, there are no differences between these surgical methods. What is known already It is known that varicocele may cause testicular dysfunction and infertility due to increased oxidative stress and sperm DNA damage. In recent meta-analyse

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Santonastaso, M., F. Mottola, C. Iovine, N. Colacurci та L. Rocco. "P–033 In vitro protective effect of α -tocopherol and anthocyanin against TiO2-NPs induced genotoxicity on human spermatozoa". Human Reproduction 36, Supplement_1 (2021). http://dx.doi.org/10.1093/humrep/deab130.032.

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Abstract Study question Do α -tocopherol and anthocyanin counteract human sperm DNA damage provoked by titanium dioxide nanoparticles (TiO2-NPs)? Summary answer: ↑-tocopherol and anthocyanin are able to counteract TiO2-NPs genotoxicity on human sperm cells reducing oxidative stress. What is known already The environmental release and the extensive use of TiO2-NPs have been implicated in poor human sperm functionality.TiO2-NPs is genotoxic on human sperm cells causing a loss of sperm DNA integrity, an increase of apoptotic process and a reduction of genomic stability related to an over producti

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Nagendra Chary.M, Lalitha B.R, and T.Anil Kumar. "A Comprehensive Understanding of Shukrala Karma in Male Infertility." AYUSHDHARA, November 15, 2021, 3566–73. http://dx.doi.org/10.47070/ayushdhara.v8i5.817.

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Male reproductive health depends upon the normal structures and functions of Shukrava srotas. Shukra is composed of both sperm and semen and considered one of the important factors for fertilization. It is stated as Phalavat shukra. Preceptors of Ayurveda have described eight types of Shukra dosha and their treatments. Low sperm count, decrease sperm motility, abnormal sperm morphology, ejaculatory problems, sexual dysfunctions, environmental exposures (radiation, pollution, and stress etc), lifestyle habits (smoking, alcohol, recreational drugs etc), varicocele, hormonal imbalances, DNA damag

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Tavalaee, Marziyeh, Mohsen Rahmani, Joël R. Drevet, and Mohammad Hossein Nasr-Esfahani. "The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review." Basic and Clinical Andrology 32, no. 1 (2022). http://dx.doi.org/10.1186/s12610-022-00157-9.

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Abstract Background Infertility related to varicocele, infections, metabolic dysfunctions, oxidative stress and environmental toxicants is also associated with inflammatory processes that ultimately lead to the activation of the inflammasome pathway (IP). IP is classically activated by DAMPs, MAMPs or LAMPs, which stand for Damage-, Microbe- or Lifestyle-Associated Molecular Patterns, respectively. The most important player in IP activation is the NLRP3 (NOD[Nuclear oligomerization domain]-, LRR[Leucine rich repeat]- and pyrin domain-containing protein 3) which functions as an intracellular se

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Mahran, Ali M., Eman Mosad, Mohamed A. Abdel‐Raheem, Eman H. Ahmed, Amira Ali Abdel Motaleb, and Eman R. Hofny. "The correlation between mammalian target of rapamycin (mTOR) gene expression and sperm DNA damage among infertile patients with and without varicocele." Andrologia 51, no. 9 (2019). http://dx.doi.org/10.1111/and.13341.

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Fang, Yiwei, Yufang Su, Jia Xu, et al. "Varicocele-Mediated Male Infertility: From the Perspective of Testicular Immunity and Inflammation." Frontiers in Immunology 12 (August 31, 2021). http://dx.doi.org/10.3389/fimmu.2021.729539.

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BackgroundVaricocele (VC) is present in 35 - 40% of men with infertility. However, current surgical and antioxidant treatments are not completely effective. In addition to oxidative stress, it is likely that other factors such as testicular immune microenvironment disorder contribute to irreversible testicular. Evidence suggests that VC is associated with anti-sperm antibodies (ASAs), spermatogenesis and testosterone secretion abnormalities, and testicular cytokine production. Moreover, inhibition of inflammation can alleviate VC-mediated pathogenesis. The normal function of the testis depends

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Se. Sharma, D. "P–072 Pregnancy rate in male factor infertility with oligoastheneteratozoospermia - evaluation of Letrozole and Coenzyme Q10 supplementation on sperm parameter." Human Reproduction 36, Supplement_1 (2021). http://dx.doi.org/10.1093/humrep/deab130.071.

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Abstract Study question Male infertility due to idiopathic oligoasthenoteratozoospermia- Does combining Letrozole as antiestrogenic with Coenzyme Q10 as antioxidant give better pregnancy rate ? Summary answer Combination of Co enzyme Q10 with Letrozole can significantly improve semen parameters and outcome of clinical pregnancy rate in idiopathic oligoasthenoteratozoospermic patients. What is known already Elevated levels of reactive oxygen species(ROS) are a major cause of idiopathic male factor infertility which results in sperm membrane lipid peroxidation, DNA damage and apoptosis leading t

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Akhigbe, Roland E., Sulagna Dutta, Moses A. Hamed, Ayodeji F. Ajayi, Pallav Sengupta, and Gulfam Ahmad. "Viral Infections and Male Infertility: A Comprehensive Review of the Role of Oxidative Stress." Frontiers in Reproductive Health 4 (February 3, 2022). http://dx.doi.org/10.3389/frph.2022.782915.

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Viral infections have been a part of human existence to date, though viruses have posed a huge threat with various outbreaks lately. These threats are associated with reproductive health challenges, especially male infertility. The prime focus of this review is to highlight the mechanisms associated with viral infection-induced male infertility/subfertility and identify new treatment strategies with the aim to preserve male fertility. The reviewed data showed that viral infections stimulate inflammatory responses, resulting in the release of proinflammatory cytokines, which induces oxidative s

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Amer, Maggie E., Azza I. Othman, Hajer Mohammed Abozaid, and Mohamed A. El-Missiry. "Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties." Biological Research 55, no. 1 (2022). http://dx.doi.org/10.1186/s40659-022-00401-6.

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Abstract Background Ionizing radiations (IR) have widespread useful applications in our daily life; however, they have unfavorable effects on reproductive health. Maintaining testicular health following IR exposure is an important requirement for reproductive potential. The current study explored the role of melatonin (MLT) in mitigating IR-induced injury in young adult rat testis. Methods Rats were given daily MLT (25 mg/kg) for 3 and 14 days after receiving 4 Gy γ-radiation. Results Serum MLT levels and other antioxidants, including glutathione content, and the activity of glutathione peroxi

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