Relevant bibliographies by topics / Vascular cell adhesion molecule

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Vascular cell adhesion molecule'

Author: Grafiati
Published: 28 May 2022
Last updated: 30 July 2025

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Journal articles on the topic "Vascular cell adhesion molecule"

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Yoshida, Norimasa, Kyoichi Kassai, Hironobu Murase, et al. "Effects ofHelicobacter pyloriWater Extract on Expression of Endothelial Adhesion Molecules." Canadian Journal of Gastroenterology 18, no. 6 (2004): 387–91. http://dx.doi.org/10.1155/2004/158638.

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The present study investigated whetherHelicobacter pyloriwater extract induces the upregulation of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin on human umbilical vein endothelial cells, using an ELISA. The nature of the substances mediating this upregulation was also analyzed.H pyloriwater extract derived from type strain (NCTC 11637) significantly upregulated intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin to the same extent as interleukin-1. Treatments with extracts from clinical strains showed no significant increas
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Fotis, Lampros, Dionysios Giannakopoulos, Lela Stamogiannou, and Maria Xatzipsalti. "Intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in children. Do they play a role in the progression of atherosclerosis?" HORMONES 11, no. 2 (2012): 140–46. http://dx.doi.org/10.14310/horm.2002.1340.

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Raynor, B. Denise, and Sampath Parthasarathy. "Vascular cell adhesion molecule in pregnancy." American Journal of Obstetrics and Gynecology 179, no. 1 (1998): 279. http://dx.doi.org/10.1016/s0002-9378(98)70303-5.

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Wuthrich, R. P. "Intercellular adhesion molecules and vascular cell adhesion molecule-1 and the kidney." Journal of the American Society of Nephrology 3, no. 6 (1992): 1201–11. http://dx.doi.org/10.1681/asn.v361201.

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Adhesion molecules such as intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are expressed in the kidney and are regulated by proinflammatory cytokines. These adhesion molecules play an important role in the binding and activation process of leukocytes and are of importance in inflammatory kidney diseases. This review article describes current knowledge regarding the structure, expression, and functional role of adhesion molecules and their significance in immune-mediated renal diseases.
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Hajialilo, M., P. Tayari, A. Ghorbanihaghjo, A. Khabbazi, A. Malek Mahdavi, and N. Rashtchizadeh. "Relationship between serum vascular cell adhesion molecule-1 and endothelin-1 levels with organ involvement and disease activity in systemic lupus erythematosus patients." Lupus 27, no. 12 (2018): 1918–25. http://dx.doi.org/10.1177/0961203318796285.

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Background Endothelial dysfunction plays an important role in pathogenesis of systemic lupus erythematosus (SLE). Considering the importance of serum soluble vascular cell adhesion molecule-1 as the most abundant of the circulating adhesion molecules increased as a result of endothelial dysfunction and the role of endothelin-1 in pathophysiology of SLE, this study aimed to evaluate serum soluble vascular cell adhesion molecule-1 and endothelin-1 levels in SLE patients compared to healthy subjects. Methods In this cross-sectional study, 60 SLE patients according to the Systemic Lupus Internatio
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Park, Sunyoung, Christine M. Sorenson, and Nader Sheibani. "PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis." Clinical Science 129, no. 3 (2015): 217–34. http://dx.doi.org/10.1042/cs20140714.

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Vascular development and maintenance of proper vascular function through various regulatory mechanisms are critical to our wellbeing. Delineation of the regulatory processes involved in development of the vascular system and its function is one of the most important topics in human physiology and pathophysiology. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), a cell adhesion molecule with proangiogenic and proinflammatory activity, has been the subject of numerous studies. In the present review, we look at the important roles that PECAM-1 and its isoforms play during angiogenesi
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Tong, Ming, Yu Jiang, Da Xia, et al. "Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients." Journal of Infectious Diseases 222, no. 6 (2020): 894–98. http://dx.doi.org/10.1093/infdis/jiaa349.

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Abstract In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase. We conclude the increased expression of endothelial cell adhesion molecules is related t
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Storer, Kingsley P., Jian Tu, Marcus A. Stoodley, and Robert I. Smee. "Expression of Endothelial Adhesion Molecules After Radiosurgery in an Animal Model of Arteriovenous Malformation." Neurosurgery 67, no. 4 (2010): 976–83. http://dx.doi.org/10.1227/neu.0b013e3181ee36bc.

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Abstract BACKGROUND: Endothelial adhesion molecules may be important in the response of brain arteriovenous malformations (AVMs) to radiosurgery. In addition to a putative role in the occlusive process after radiosurgery, they may serve as potential targets for biological strategies to accelerate intravascular thrombosis. OBJECTIVE: To determine the temporal expression of E-selectin and vascular cell adhesion molecule-1 in an animal model of AVMs. METHODS: Forty-one Sprague-Dawley rats underwent surgical creation of a carotid-to-jugular anastomosis. Radiosurgery (25 Gy) was delivered to the mo
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Langley, Robert R., Janice Russell, Michael J. Eppihimer, et al. "Quantification of murine endothelial cell adhesion molecules in solid tumors." American Journal of Physiology-Heart and Circulatory Physiology 277, no. 3 (1999): H1156—H1166. http://dx.doi.org/10.1152/ajpheart.1999.277.3.h1156.

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Coordinated adhesive interactions between lymphocyte receptors and endothelial cell adhesion molecules (CAMs) are a prerequisite for effector cell entry into tumor stroma. Whereas the diminished leukocyte-endothelial cell interactions observed in tumor microvessels have been attributed to a reduced expression of endothelial CAMs, there is no quantitative data bearing on this issue. The dual-radiolabeled monoclonal antibody technique was used to quantify constitutive and tumor necrosis factor (TNF)-α-induced expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecu
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Lee, Tae Hoon. "Lactoferrin inhibits immune cell adhesion via suppression of cell adhesion molecules expression in hypoxia/reoxygenation animal model." Journal of Immunology 200, no. 1_Supplement (2018): 42.10. http://dx.doi.org/10.4049/jimmunol.200.supp.42.10.

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Abstract Lactoferrin (Lf), an 80 kDa iron binding protein, belongs to transferrin family found in secretions such as milk and in plasma secreted from neutrophils granules upon inflammatory stimulation. Lf is a multifunctional protein mainly involved in both the innate and adaptive immune defenses. In this study, we investigated the anti-adherent activity of Lf in hypoxia/reoxygenation (H/R)-stimulated human endothelial cells (HUVECs). Lf dramatically reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by hypoxia-situation HUVECs.
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Dissertations / Theses on the topic "Vascular cell adhesion molecule"

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Brown, Marena Dessette. "Sickle cell-endothelial interactions : modulation of cell adhesion molecule expression." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/11306.

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Cooke, Vesselina G. "Role of Junctional Adhesion Molecule-A in vascular biology." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 147 p, 2008. http://proquest.umi.com/pqdweb?did=1495945061&sid=5&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Alapati, Anuja. "Small Organic Molecule Inhibition of Tumor Necrosis Factor-a Induced Vascular Cell Adhesion Molecule-1 Expression by Endothelial Cells." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1375177527.

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Wu, Tao. "Structure-function analysis of vascular tethering molecules using atomic force microscope." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31844.

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Thesis (Ph.D)--Mechanical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Zhu, Cheng; Committee Member: Barry, Bridgette; Committee Member: Boyan, Barbara; Committee Member: McEver, Rodger; Committee Member: McIntire, Larry. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Ramrakha, Punit Satyavrat. "Strategies to modulate leukocyte adherence to endothelium : inhibition of vascular cell adhesion molecule expression." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402448.

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Koßmann, Eugen Franz Josef [Verfasser]. "Vascular Cell Adhesion Molecule-1 (VCAM-1) modulates plasticity of human melanoma cells / Eugen Franz Josef Koßmann." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1233008927/34.

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Fukiage, Kenichi. "Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells." Kyoto University, 2010. http://hdl.handle.net/2433/120604.

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Mulgrew, Scott. "Fatty acid regulation of adhesion molecule expression in human vascular cells." Thesis, Robert Gordon University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526063.

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Gandhi, Neha Sureshchandra. "Molecular modelling of platelet endothelial cell adhesion molecule 1 and its interaction with glycosaminoglycans." Thesis, Curtin University, 2007. http://hdl.handle.net/20.500.11937/1513.

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The Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) has many functions including its roles in leukocyte extravasation as part of the inflammatory response, and in the maintenance of vascular integrity through its contribution to endothelial cell-cell adhesion. Various heterophilic ligands of PECAM-1 have been proposed. The possible interaction of PECAM-1 with glycosaminoglycans (GAGs) is the focus of this thesis. The three dimensional structure of the extracellular immunoglobulin (Ig)-domains of PECAM-1 was constructed using homology modelling and threading methods. Potential heparin/h
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Amos, Amanda Owings. "Regulation of cytokine-induced adhesion molecule expression and sickle erythrocyte adhesion to microvascular endothelial cells by intracellular adenosine 3',5'-cyclic monophosphate and nitric oxide." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-04052006-104355/.

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Thesis (Ph. D.)--Chemical and Biomolecular Engineering, Georgia Institute of Technology, 2006.<br>Dr. Peter A. Lane, Committee Member ; Dr. Larry V. McIntire, Committee Member ; Dr. Ronald W. Rousseau, Committee Member ; Dr. James R. Eckman, Committee Member ; Dr. Timothy M. Wick, Committee Chair.
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Books on the topic "Vascular cell adhesion molecule"

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D, Pearson Jeremy, ed. Vascular adhesion molecules and inflammation. Birkhäuser, 1999.

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D, Pearson Jeremy, ed. Vascular adhesion molecules and inflammation. Birkhäuser, 1999.

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L, Gordon J., ed. Vascular endothelium: Interactions with circulating cells. Elsevier, 1991.

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Bereta, Joanna. Regulation of expression of vascular cell adhesion molecule-1 and inducible nitric oxide synthase in murine brain microvascular endothelium. Wydawn. Uniwersytetu Jagiellońskiego, 1997.

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Dominique, Bagnard, ed. Neuropilin: From nervous system to vascular and tumor biology. Kluwer Academic/Plenum Pub., 2002.

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Dominique, Bagnard, ed. Neuropilin: From nervous system to vascular and tumor biology. Kluwer Academic/Plenum Pub., 2002.

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Dominique, Bagnard, ed. Neuropilin: From nervous system to vascular and tumor biology. Kluwer Academic/Plenum Pub., 2002.

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Gallagher, Helen Christine. Regulation of neural cell adhesion molecule polysialylation state. University College Dublin, 1998.

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Berezin, V. A. Structure and function of the neural cell adhesion molecule NCAM. Springer, 2010.

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Berezin, Vladimir, ed. Structure and Function of the Neural Cell Adhesion Molecule NCAM. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-1170-4.

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Book chapters on the topic "Vascular cell adhesion molecule"

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Salajegheh, Ali. "Vascular Cell Adhesion Molecule-1 (VCAM-1)." In Angiogenesis in Health, Disease and Malignancy. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28140-7_59.

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Qidwai, Tabish. "Vascular Cell Adhesion Molecule-1 (VCAM-1) Polymorphisms." In Exploration of Host Genetic Factors associated with Malaria. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4761-8_14.

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Clements, J. M., R. Pigott, L. A. Needham, and A. J. H. Gearing. "Adhesion molecules in disease: vascular cell adhesion molecule-1 as a target for therapy." In The Vasculitides. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-2889-4_6.

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Derosa, Giuseppe, and Pamela Maffioli. "Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression in Liver Disease." In Biomarkers in Disease: Methods, Discoveries and Applications. Springer Netherlands, 2017. http://dx.doi.org/10.1007/978-94-007-7675-3_24.

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Derosa, Giuseppe, and Pamela Maffioli. "Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression in Liver Disease." In Biomarkers in Disease: Methods, Discoveries and Applications. Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-007-7742-2_24-1.

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Yoshikawa, Toshikazu, Norimasa Yoshida, Hiroki Manabe, Yoshimitsu Terasawa, Toshiki Takemura, and Motoharu Kondo. "Effect of α-Tocopherol on Expression of Intercellular Adhesion Molecule-1 and Vascular Adhesion Molecule-1 on Human Vascular Endothelial Cells." In Food Factors for Cancer Prevention. Springer Japan, 1997. http://dx.doi.org/10.1007/978-4-431-67017-9_91.

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Blease, Kate, Paul G. Hellewell, and Anne C. Burke-Gaffney. "Expression and Functional Consequences of Cytokine- or Lipopolysaccharide-Induced Adhesion Molecule Expression on Human Lung Microvascular Endothelial Cells." In Vascular Endothelium. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-0133-0_19.

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Khandoga, A., S. Hüttinger, A. G. Khandoga, et al. "The role of Endothelial Cell-Selective Adhesion Molecule (ESAM) for leukocyte migration and vascular permeability during hepatic ischemia-reperfusion." In Deutsche Gesellschaft für Chirurgie. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00625-8_61.

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Sato, Thomas N., and Ying Qin. "A Novel Gene Family May Encode Endothelial Cell Specific Adhesion-Like Molecules: An Extracellular Loop-Repeat-Loop (LRL) Motif and Cytoplasmic Tyrosine Kinase Domains." In Frontiers in Cerebral Vascular Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2920-0_29.

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Holdenrieder, S., and P. Stieber. "Neural Cell Adhesion Molecule." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_2245-1.

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Conference papers on the topic "Vascular cell adhesion molecule"

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Weidert, Eric, Payal Khanna, Francisco Vital-Lopez, and Cheng Dong. "Model Simulations Reveal VCAM-1 Augment PAK Activation Rates to Amplify p38 MAPK and VE-Cadherin Phosphorylation." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80364.

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Metastasis is a complex process mediated by both adhesion molecules and chemokine secretion [1]. One important event during cancer metastasis is tumor cell extravasation through the endothelium [1]. In melanoma cancer, tumor cell extravasation is mediated by very late antigen (VLA)-4 molecule adhesion to vascular cell adhesion molecules (VCAM)-1 on endothelial cells [2]. High expression levels of VLA-4 integrin are associated with a marked increase in melanoma extravasation through endothelial layers [2]. The binding of VLA-4 to VCAM -1 induces the activation of downstream mitogen activated pr
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Rossi, Joanna, Léonie Rouleau, Jean-Claude Tardif, and Richard L. Leask. "Fluid Shear Stress Reduces Simvastatin Induced Adhesion Molecule Expression in Cytokine Activated Endothelial Cells." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206539.

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Although originally designed as inhibitors of cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, are now known to also have non-lipid lowering benefits [1]. Statins have been reported to modulate gene expression in endothelial cells, however, the effect of statins on adhesion molecule expression is contradictory. Some studies report a decrease in adhesion molecule mRNA and/or protein after statin treatment [2], while others have shown that statins potentiate the effect of tumor necrosis factor alpha (TNFα) [3]. To the best of our knowled
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Imai, Yohsuke, Hitoshi Kondo, Young Ho Kang, Takuji Ishikawa, Chwee Teck Lim, and Takami Yamaguchi. "A Numerical Model of Adhesion Property of Malaria Infected Red Blood Cells in Micro Scale Blood Flows." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206456.

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Infection by malaria parasite changes mechanical properties of red blood cells (RBCs). Infected red blood cells (IRBCs) lose the deformability but also develop the ability to cytoadhere and rosetting. These outcomes can lead to microvascular blockage [1]. The stiffness of IRBCs [2] and its effects on the flow in micro channels [3] were studied with recent experimental techniques. The cytoadherence and rosetting properties of IRBCs have also been studied experimentally. The cytoadherence is mediated by the interaction of the parasite protein PfEMP1 with several endothelial adhesion molecules, s
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Al-Mrabt, N., TA Martin, and WG Jiang. "Abstract P1-02-03: JAM-2, Junctional Adhesion Molecule-2 Influences the Adhesion and Migration of Vascular Endothelial Cell." In Abstracts: Thirty-Third Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 8‐12, 2010; San Antonio, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/0008-5472.sabcs10-p1-02-03.

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Kopacz, Adrian M., Brandon J. Tefft, Shu Q. Liu, and Wing K. Liu. "Modeling of Endothelial Cell Adhesion Dynamics Modulated by Molecular Engineering." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13269.

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Vascular thrombosis, intimal hyperplasia, and atherosclerosis are common disorders affecting a very large portion of the human population. A potential reduction in these disorders will elicit a significant impact. It has been shown that endothelial cells play a critical role in protecting blood vessels against the formation of thrombosis and atherosclerosis. Hence, a successful endothelial cell lining of arterial constructs will prevent intimal hyperplasia in reconstructed arteries. However, in practice endothelial cells often detach from reconstructed arteries due to weak adhesion strength, h
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Gimbrone, M. A., M. P. Bevilacqua, and M. E. Wheeler. "ENDOTHELIAL-DEPENDENT MECHANISMS OF LEUKOCYTE ADHESION: ROLE OF MONOKINES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643983.

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Localized adhesion of peripheral blood leukocytes to the vessel wall is an essential component of inflammatory reactions. There is increasing experimental evidence that vascular endothelial cells play an active role in this process. Our laboratory has been especially interested in defining endothelial-dependent mechanisms of leukocyte adhesion, and the role of leukocyte products in their modulation. We have reported1 that purified natural human monocyte-derived interleukin 1 (IL-1) can act directly on cultured human endothelial cells (HEC) to dramatically increase the adhesiveness of their sur
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Graham, Drew A., Danil V. Dobrynin, Alexander Fridman, Gary Friedman, and Alisa Morss Clyne. "A Pin-to-Hole Spark Discharge Plasma Generates Nitric Oxide and Can Be Safely Applied to an Endothelial Cell Monolayer." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206764.

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Endothelial cells line all blood vessels and regulate many homeostatic functions (e.g. platelet aggregation, vascular tone, vascular cell proliferation, leukocyte adhesion) by production of the signaling molecule nitric oxide (NO). NO bioavailability and thus endothelial cell function are compromised in many chronic disease states, including diabetes mellitus and its associated micro- and macrovascular complications (e.g. impaired wound healing and atherosclerosis, respectively) [1]. In the specific case of diabetic wound healing, application of exogenous NO to the diseased tissue may help res
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Henretta, Melissa, Jennifer M. Scalici, Linda Duska, Jill Slack-Davis, and Kristen Atkins. "Abstract 845: Vascular cell adhesion molecule-1 (VCAM-1) expression in patients with ovarian tumors of low malignant potential." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-845.

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Oleszowsky, Mara, Widian Laaraj, Tanja Kottmann, and Matthias Seidel. "AB1330 SOLUBLE VASCULAR CELL ADHESION MOLECULE-1 AS AN INDEPENDENT MARKER FOR ENDOTHELIAL ACTIVATION IS ELEVATED IN ACTIVE RHEUMATIC DISEASES: A MULTIVARIATE ANALYSIS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.3085.

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Sanders, Andrew James, David Guo Jiang, Jianyuan Zeng, et al. "Abstract PS17-48: Potential role of activated leukocyte cell adhesion molecule (ALCAM) in hepatocyte growth factor (HGF) signalling in vascular endothelial cells and implications in breast cancer." In Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.sabcs20-ps17-48.

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Reports on the topic "Vascular cell adhesion molecule"

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Lin, Sue-Hwa. Tumor Specific Regulation of C-CAM Cell Adhesion Molecule in Prostate Cancer Carcinogenesis. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada393974.

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Resnick, Nicole M. The Expression and Regulation of the Cell Adhesion Molecule CD44 in Human Breast Cancer. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada300406.

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Mahanonda, Rangsini, Orawan Charatkulangkun, and Sathit Pichyangkul. The role of IL-17 in periodontitis. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.12.

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Background and objectives: IL-17 is a novel T cell-derived cytokine that promotes inflammatory responses. It is presence in inflamed gingival tissues and gingival crevicular fluid of periodontitis patients. In this study we investigated the effects of IL-17 alone or in combination with IFN-Y on the immune modulation of human gingival fibroblasts (HGFs) which would contribute to pathogenesis of periodontium. Methods and results: Various concentrations of IL-17, IFN-Y or the combination of these two cytokines were added to HGF cultures. The expression of ICAM-1, HLA-DR, and CD40 was assessed by
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