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Dissertations / Theses on the topic 'Vascular tumors of neck'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Bradburn, Jennifer Elizabeth. "Reactive species promotion of head and neck squamous cell carcinoma." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1166555968.

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2

Chan, Chiu-lung Richie, and 陳肖龍. "Mucosal melanoma of the head and neck." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632876.

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3

Tu, Jidong 1964. "The simulation of bidirectional ultrasound hyperthermia treatments of neck tumors." Thesis, The University of Arizona, 1992. http://hdl.handle.net/10150/278165.

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The temperature distributions produced in neck tumors by using either a single, scanned transducer (a unidirectional scan) or two separate transducers whose axis were perpendicular (a bidirectional scan) were simulated. The three dimensional neck model included separate anatomical regions for the normal neck muscle tissue, the tumor, the spinal column and the trachea. The effects of variations in the transducer frequency and f-number, the tumor size and location, and the normal and tumor blood perfusion rates were established. The results indicate that the best temperature distributions will b

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4

Markkola, Antti. "Spin lock and magnetization transfer imaging of head and neck tumors." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/markkola/.

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5

Hunter, Keith David. "Gene expression analysis of head and neck cancer development." Thesis, University of Glasgow, 2005. http://theses.gla.ac.uk/1712/.

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Microarray analysis was performed on 32 head and neck keratinocytes cultures using Affymetrix U133A/B genechips. The panel of cultures included normal cells, mortal and immortal cultures of dysplastic keratinocytes and mortal and immortal cultures from carcinomas, all grown to a standard protocol. The overall GEP revealed that many of the well-established HNSCC molecular markers associated with motility and invasion were up-regulated in the mortal cells, particularly in the mortal carcinomas. Immortal NHSCC cells showed elevated expression of cell-cycle markers and loss of differentiation mark

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6

Modasia, Bhavika. "PTTG, PBF and p53 in head and neck cancer." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7574/.

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Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and poses a significant health burden due to its rising incidence. The proto-oncogene PTTG is overexpressed in HNSCC and correlates with poor patient prognosis. A recent unpublished GEO profile eDNA array analysis has further suggested a potential upregulation of its binding partner PBF in HNSCC. PTTG and PBF cause transformation in vitro and tumour formation in vivo, both effects thought to be partly mediated by their interactions with the tumour suppressor protein p53. Dysregulation of the p53 pathway is fr

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7

MISSALE, FRANCESCO. "Immune contexture monitoring in solid tumors focusing on Head and Neck Cancer." Doctoral thesis, Università degli studi di Brescia, 2023. https://hdl.handle.net/11379/570176.

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Forti evidenze dimostrano una stretta interazione tra il sistema immunitario e lo sviluppo biologico e la progressione clinica dei tumori solidi. L'effetto che il microambiente immunitario del tumore può avere sul comportamento clinico della malattia è indicato come "immunecontexture". Nonostante ciò, l'attuale gestione clinica dei pazienti affetti da cancro non tiene conto di alcuna caratteristica immunologica né per la stadiazione né per le scelte terapeutiche. Il tumore della testa e del collo (HNSCC) rappresenta il 7° tumore più comune al mondo ed è caratterizzato da una prognosi relativam

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8

Moutasim, Karwan A. "Integrin avb6 : expression and function in head and neck cancer." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/374708/.

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9

Marcu, Loredana Gabriela. "Deterministic modelling of kinetics and radiobiology of radiation-cisplatin interaction in the treatment of head and neck cancers." Title page, contents and abstract only, 2004. http://hdl.handle.net/2440/37961.

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One of the main objectives of combining radiation treatment and chemotherapy is to obtain a therapeutic gain by an improved tumour control with less or no enhancement of normal tissue toxicity. The optimal schedule for the combined treatment of cisplatin-radiation is still under investigation. Neither the optimal time interval, nor the most adequate sequence of administration of cisplatin and radiation are known. The results of the trials are also inconclusive. Some trials showed a supra-additive effect from the administration of cisplatin before radiotherapy, others, on contrary, from the inj

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10

Chen, Xiuyun. "Fine needle aspiration cytology in the study of neck mass." Thesis, Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31970928.

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11

McCaul, James A. "Telomere function and the radiosensitivity of squamous carcinoma of the head and neck." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/4117/.

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This thesis considers whether the alteration of telomere function by manipulation of the telomerase enzyme can affect the radiosensitivity of in vivo derived SCCHN cells and hence whether telomere dysfunction inducing strategies are likely to be synergistic with ionising radiation in the management of SCCHN. The role of telomerase in radioprotecting cancer cells is investigated using the ectopic expression of hTERT in cell lines with high and low levels of telomerase. The effect of inhibiting telomerase expression is examined using a dominant negative telomerase gene. This approach had little

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12

Lam, Chi-tat. "Identification of brain-derived neurotrophic factor (BDNF) as a novel angiogenic factor in tumor angiogenesis." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290355.

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13

Berthon, Beatrice. "Optimisation of Positron Emission Tomography based target volume delineation in head and neck radiotherapy." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/69184/.

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Automatic segmentation of tumours using Positron Emission Tomography (PET) was recommended for radiotherapy treatment (RT) planning of head and neck (H&N) cancer patients, and investigated in the scientific literature without reaching a consensus on the optimal process. This project aimed at evaluating the performance of PETCbased automatic segmentation (PETCAS) methods and developing an optimal PETC AS process to be used at Velindre Cancer Centre (VCC). For this purpose, ten algorithms were implemented to represent the most promising PETCAS approaches from a systematic review of the literatur

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14

Dahlgren, Liselotte. "Studies on the presence and influence of human papillomavirus (HPV) in head and neck tumors /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-289-6/.

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15

Aslam, Mohammed Afeef. "An investigation of GRP78 expression and inhibition in squamous cell carcinoma of the head and neck." Thesis, University of Liverpool, 2011. http://livrepository.liverpool.ac.uk/3813/.

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GRP78 is a known cyto-protective gene which is induced in microenvironments typical of tumours with low glucose and hypoxia. Furthermore up-regulation of GRP78 has been linked to chemo- and radioresistance as well as poor survival outcome. This study is the first to confirm that GRP78 is up-regulated in tumours of the oropharynx, larynx and hypopharynx compared with matched histologically normal tissue (p(Χ2)<0.001). Up-regulation of GRP78 may be important for tumour development and therefore we have investigated the consequences of inhibition of GRP78 in cells derived from laryngeal squamous

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16

Lymboussaki, Athina. "Vascular endothelial growth factors and their receptors in embryos, adults and in tumors." Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/lymboussaki/.

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17

Reid, Katherine Jane. "The experience of patients diagnosed and treated for head and neck cancer." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4333/.

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Head and neck cancer (H&NC) and its possible treatment options are diverse and multifaceted. This thesis demonstrates these complexities and describes three studies that have used different methodological approaches to include, rather than overlook these aspects. The first established which aspects of patients’ experiences are overlooked if health care professionals rely upon health related quality of life questionnaires to represent the experience of patients. The second identified that the multi-disciplinary team (MDT) working with the patients use humane judgement, not technical expertise,

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18

Catrina, Sergiu-Bogdan. "Regulators of angiogenesis in diabetes and tumors /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-628-6682-6/.

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19

Van, Tol Markus Lane. "A graph-based method for segmentation of tumors and lymph nodes in volumetric PET images." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/2290.

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For radiation treatment of cancer and image-based quantitative assessment of treatment response, target structures like tumors and lymph nodes need to be segmented. In current clinical practice, this is done manually, which is time consuming and error-prone. To address this issue, a semi-automated graph-based segmentation approach was developed. It was validated with 60 real datasets, segmented by two users manually and with this new algorithm, and 44 scans of a phantom dataset. The results showed a statistically significant improvement in intra- and interoperator consistency of segmentations,

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20

Nutting, Christopher. "Can intensity-modulated radiotherapy (IMRT) be used to reduce toxicity and improve tumour control in patients with head and neck cancer?" Thesis, City University London, 2012. http://openaccess.city.ac.uk/1128/.

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Radiotherapy is commonly used in the treatment of head and neck cancer. For early stage tumours, conventional radiotherapy techniques have a high cure rate and low levels of long-term complications. Patients with more advanced cancers have much lower cure rates and high levels of treatment-related complications. Intensity modulated radiotherapy (IMRT) is a new form of focussed radiation therapy. It has been used to reduce the radiation dose to normal tissue structures and increase the dose delivered to tumour bearing tissues. This potentially allows reduced side effects and increased tumour co

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21

Lam, Chi-tat, and 林知達. "Identification of brain-derived neurotrophic factor (BDNF) as a novel angiogenic factor in tumor angiogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290355.

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22

Cupparo, Ilaria. "Region growing and fuzzy C-means algorithm segmentation for PET images of head-neck tumours." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18020/.

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The aim of this work, performed at Azienda Ospedialiero Universitaria in Modena, is the implementation and validation of autosegmentation methods of head and neck (H&N) tumor PET images. These autosegmentation processes are important mostly to overcome the problems of manual segmentation, performed by radiotherapist physician, regarding the contouring time (that can reach more than two hours) and the intra-observer and inter-observer variability. Fuzzy C-means (FCM) and Region Growing (RG) algorithms were developed in a MATLAB GUI that allows to choice iteratively the different steps necessary

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23

Hautea, Rhea P. "Vitamin D- induced down regulation of RAD51 in head and neck squamous cell carcinoma (HNSCC), In Vitro and In Vivo." Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/786.

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The active form of Vitamin D (VD3) has been shown to induce pro-apoptotic and anti-proliferative effects in several mammalian cancer cell types. The molecular mechanisms of tumor suppression, however, are not clearly understood. Previous research has shown that head and neck squamous cell carcinoma (HNSCC) responds to VD3. This thesis used both in vivo and in vitro models to examine the effect of VD3 in HNSCC. Former work in the Albala laboratory showed that hamsters that received systemic VD3 and topical treatment of 7,12-dimethylbenz(a)anthracene (DMBA) to the buccal pouch showed no or delay

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24

Trindade, Alexandre José Neto. "Análise da função de Delta4 na regulação da angiogénese embrionária e neo-angiogénese tumoral." Doctoral thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2008. http://hdl.handle.net/10400.5/511.

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Tese de Doutoramento em Ciência e Tecnologia Animal<br>O correcto desenvolvimento dos embriões de metazoários segmentados depende do desenvolvimento de um sistema vascular sanguíneo, um processo regulado a vários níveis. Este passo do desenvolvimento embrionário passa por vários eventos morfogenéticos, que resultam na conversão funcional de células progenitoras, responsivas a factores pró-angiogénicos, em redes complexas de vasos sanguíneos, que cobrem todo o organismo e acompanham o crescimento do embrião. O desenvolvimento do sistema vascular é um processo dinâmico, em que as células endotel

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25

Garcia, Emmanuel. "Blood flow responses to mild-intensity exercise in ectopic versus orthotopic prostate tumors: dependence upon host-tissue hemodynamics and vascular reactivity." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/32858.

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Master of Science<br>Department of Kinesiology<br>Bradley J. Behnke<br>Given the critical role of tumor O₂ delivery on patient prognosis and the rise in preclinical exercise-oncology studies, we investigated tumor and host-tissue blood flow at rest and during exercise as well as vascular reactivity using a rat prostate cancer model grown in two transplantation sites. Methods. In male COP/CrCrl rats, blood flow (via radiolabeled microspheres) to prostate tumors (R3327-MatLyLu cells injected in the left flank (ectopic) or ventral prostate (orthotopic)) and host-tissue was measured at rest and du

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26

Baboci, Lorena. "Human papillomavirus - associated head and neck squamous cell carcinomas in North-East Italy." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423688.

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Background: Specific oncogenic types of human papillomaviruses (HPV), most frequently HPV16, are causally associated with a subset of head and neck squamous cell carcinomas (HNSCC). HPV DNA associated tumors appear to be heterogeneous in prevalence over time and geographically, in the oncogenic activity (direct and indirect viral markers) and clinical behavior. However, it remains unclear which biomarkers can reliably determine which HNSCC are truly driven by HPV transformation. Aims: In the present thesis, the first aim was to determine the prevalence of the truly HPV-associated HNSCC tumors

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27

Araujo, Robyn Patrice. "Mathematical modelling of mechanical stresses and vascular collapse in solid tumours." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/37156/6/37156_Digitised_Thesis.pdf.

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28

Neuholz, Alexander [Verfasser], and Joao Carlos [Akademischer Betreuer] Seco. "3D characterization of vascular architectures in experimental tumors based on LSFM microscopy and simulation of the oxygen distributions / Alexander Neuholz ; Betreuer: Joao Carlos Seco." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1239737394/34.

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29

Marshall, Jocelyn R. "A Study of the Impact of Membrane Organization of Glycosphingolipid E-selectin Ligands and Glycoproteins on Head and Neck Cancer Cell Adhesion to Vascular Endothelium." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1313073422.

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30

Guix, Arnau Marta 1974. "Mechanisms of acquired resistance to anti-EGFR therapies in squamous cell carcinoma." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/565440.

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Targeted therapies against the Epidermal Growth Factor Receptor (EGFR) are useful to treat many human cancers such as non-small cell lung cancer, colorectal cancer and head and neck cancer. However, the efficacy of such treatments is always compromised by resistance. This doctoral thesis has focused in the mechanisms of acquired resistance to targeted therapies against the EGFR (such as the small tyrosine kinase inhibitors gefitinib and erlotinib, or the monoclonal antibody cetuximab) in squamous cell carcinomas. In the first part of the thesis, preclinical studies with cellular and xenograft

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31

Burkes, Shona A. "Quantitative Multimodal Skin Imaging in Pediatric Health Care: Infantile Hemangiomas and Hypertrophic Burn Scars." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396532858.

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32

CHITI, LAVINIA ELENA. "GAMMA-PROBE GUIDED SENTINEL LYMPH NODE EXTIRPATION TO ASSESS PATTERNS OF NODAL METASTASIS IN SPONTANEOUS HEAD AND NECK MALIGNANCIES OF THE DOG: A SECOND STEP BASED ON PREVIOUS EXPERIENCES ON MAST-CELL TUMORS." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/916665.

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Canine oncology has recently reported interest in the detection of occult nodal metastases, and efforts have been made to identify the best strategy for accurate nodal staging. In this scenario, the present PhD thesis was aimed to improve knowledge on the current understanding of the feasibility and impact of sentinel lymph node (SLN) mapping with radiopharmaceutical and blue dye in cancer-bearing dogs. Initially, we evaluated the technique in canine mast cell tumors (MCT), given the high prevalence of this tumor type, the propensity for lymphatic spread and recognized prognostic impact of nod

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33

Miniello, Thais Gimenez. "Fatores preditivos, prevalência e tratamento de osteorradionecrose em pacientes irradiados em região de cabeça e pescoço." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-30092016-165829/.

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Introdução: Pacientes com tumores de cabeça e pescoço (CP) podem apresentar algumas complicações orais decorrentes do tratamento radioterápico. A osteorradionecrose (ORN) pode ser um dos efeitos colaterais tardios desse tipo de tratamento. Na literatura, análises retrospectivas em que foram coletados dados sobre a ocorrência da ORN são vistas com maior frequência. Entretanto, ainda não foram realizados estudos que correlacionem dados como o tipo de irradiação, a dose utilizada para tratamento do tumor, as características clínicas e o tratamento da ORN em pacientes que foram irradiados em regiã

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34

Graciolli, Fabiana Giorgeti. "Proteínas ósseas envolvidas na calcificação vascular de ratos urêmicos, paratireoidectomizados, alimentados com dieta rica e pobre em fósforo associada à infusão fixa de paratormônio." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-27042007-140434/.

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Local invasion and lymph nodal spread impact in the outcome of Head and Neck squamous cell carcinoma (HNSCC) patients (pts). We determined CXCR1-5, CCR7 and CX3CR1 mRNA expression by means of RNAse protection assay in 98 HNSCC primary tumors and 91 adjacent mucosa and 26 metastatic lymph nodes, correlating this data with outcome. CXCL12 and CCL19/CCL21, ligands for CXCR4 and CCR7, were determined in 38 tumor fragments, 33 adjacent mucosas and 25 de metastatic lymph nodes, by means of Quantitative Real-Time PCR. Tumors presented higher CXCR1 (P=0.013), CXCR3 (P=0.008) and CXCR4 mRNA (P=0.025) e

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35

Volz, Julia [Verfasser], Bernhard [Gutachter] Nieswandt, Süleyman [Gutachter] Ergün, and Guido [Gutachter] Stoll. "Studies on the influence of platelets on vascular integrity in primary tumors and the role of BIN2 in platelet calcium signaling / Julia Volz ; Gutachter: Bernhard Nieswandt, Süleyman Ergün, Guido Stoll." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1222910594/34.

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36

Puig, Saus Cristina. "Estratègies de millora de la potència antitumoral dels adenovirus oncolítics basades en l’increment de l’alliberament viral i l’extravasació vascular." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/123285.

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La viroteràpia amb adenovirus oncolítics es basa en la lisi selectiva de la cèl•lula tumoral a través de la replicació viral. Les principals limitacions d’aquesta teràpia són: la limitada arribada del virus al tumor després de l’administració sistèmica, la baixa dispersió intratumoral i la resposta immune antiviral. En aquesta tesi hem presentat estratègies per millorar la disseminació intratumoral basades en l’augment de l’alliberament viral i en la millora de l’extravasació i penetració del virus al parènquima tumoral, augmentant en els dos casos l’eficàcia antitumoral. Una de les principa

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37

López, Rossana Verónica Mendoza. "Papilomavírus humano e prognóstico de tumores de cabeça e pescoço." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/6/6132/tde-20012012-145544/.

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Introdução. O Papilomavírus humano (HPV), particularmente o tipo 16, têm sido associado com risco e prognóstico de tumores de cabeça e pescoço. Contudo, o papel do DNA do HPV e resposta sorológica na sobrevida neste grupo de pacientes ainda não está claro. Objetivos. Avaliar o efeito do HPV (resposta sorológica e detecção do DNA no tecido tumoral) na sobrevida de pacientes com carcinoma epidermóide de cabeça e pescoço, considerando-se as distintas localizações anatômicas (cavidade oral, orofaringe, hipofaringe e laringe). Material e métodos. Coorte de 1.475 pacientes com carcinoma epidermóide

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38

Roche, Desgranges Emmanuelle. "Effet d’agonistes de PPARβ sur l’expression du VEGF (Vascular Endothelial Growth Factor) et des cadhérines E et N dans des modèles de cancers épithéliaux". Thesis, Besançon, 2012. http://www.theses.fr/2012BESA3002/document.

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Le potentiel invasif et métastatique d'une tumeur est contrôlé par l'angiogenèse via le VEGF (Vascular Endothelial Growth Factor) et les altérations des systèmes impliqués dans l'adhérence cellulaire via les cadhérines. Dans ce travail, nous montrons que le L-165041, agoniste du récepteur nucléaire PPARβ (Peroxisome Proliferator-Activated Receptor) régule l'expression du VEGF dans des cellules dérivées de cancer du col de l'utérus dont le facteur étiologique est un papillomavirus (HPV). Cependant, cet effet est observé uniquement dans des cellules HPV18 indépendamment de l'oncoprotéïne virale

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Luca, Manoela Dias de. "Necessidades de autocuidado à qualidade de vida de clientes com câncer de cabeça e pescoço: contribuição da enfermagem." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3699.

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Aborda-se a consulta de enfermagem como estratégia de pesquisa, visando identificar necessidades de autocuidado (AC) em clientes com câncer de cabeça e pescoço em tratamento paliativo ambulatorial. Tem-se como objetivos: identificar o perfil sociodemográfico e nosológico dos clientes com câncer de cabeça e pescoço atendidos no ambulatório para cuidados paliativos; identificar a qualidade de vida (QV) dessas pessoas através da consulta de enfermagem; avaliar as mudanças no sistema de autocuidado, considerando a intervenção de enfermagem. O estudo fundamenta-se nos conceitos, protocolos e instr

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40

Bechet, Denise. "Traitement photodynamique interstitiel vasculaire stéréotaxique des tumeurs cérébrales guidé par imagerie : intérêt des nanoparticules multifonctionnelles ciblant neuropiline-1." Thesis, Nancy 1, 2011. http://www.theses.fr/2011NAN10119.

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La thérapie photodynamique (PDT) appliquée aux tumeurs cérébrales est évaluée comme une stratégie complémentaire par rapport aux thérapies conventionnelles. De nombreux travaux mettent en exergue le rôle prépondérant joué par l'effet vasculaire de la PDT dans l'éradication tumorale. Ainsi, une accumulation sélective du photosensibilisateur au niveau des néo-vaisseaux tumoraux favorise cet effet et donc, l'efficacité du traitement photodynamique. La stratégie vasculaire consistant à coupler un photosensibilisateur à un peptide ligand pour cibler le récepteur neuropiline-1 (NRP-1) surexprimé par

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41

Azemar, Nathan. "Μοdélisatiοn des tοxicités οptiques induites par radiοthérapie avec faisceaux de prοtοns". Electronic Thesis or Diss., Normandie, 2024. https://theses.hal.science/tel-04947852.

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La protonthérapie, grâce à sa capacité à délivrer des doses élevées aux tumeurs tout en épargnant les tissus sains, est une option thérapeutique privilégiée pour traiter des localisations proches des structures optiques. Cependant, les rayonnements peuvent endommager les voies visuelles et causer des déficits visuels sévères. Cette thèse vise à modéliser les toxicités optiques induites par la protonthérapie chez les patients traités pour des tumeurs de la tête et du cou. Le travail repose sur l’analyse de données dosimétriques et paracliniques collectées auprès de 223 patients traités par prot

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42

Chicote, Patricia Matos Biselli. "Expressão de isoformas do gene VEGF e de proteínas reguladoras de splicing em carcinoma espinocelular de cabeça e pescoço." Faculdade de Medicina de São José do Rio Preto, 2011. http://bdtd.famerp.br/handle/tede/112.

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Made available in DSpace on 2016-01-26T12:51:32Z (GMT). No. of bitstreams: 1 patriciamatosbisellichicote_tese.pdf: 6274386 bytes, checksum: 571eca1fa48891d23de56db3c1872459 (MD5) Previous issue date: 2011-11-17<br>Tumor growth and progression depend on angiogenesis, a process that involves the formation of new blood vessels from a preexisting vascular endothelium. Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and its overexpression is associated with tumor growth and metastasis. However, the selection of a alternative splicing site at the end of the exon

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Lopes, Rute Belmira Martins Crespo Paula. "Metabolic guided vascular analysis of brain tumors using MR/PET." Master's thesis, 2016. http://hdl.handle.net/10451/27394.

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Tese de mestrado integrado, Engenharia Biomédica e Biofísica (Radiações em Diagnóstico e Terapia)Universidade de Lisboa, Faculdade de Ciências, 2016<br>As técnicas de imagiologia são uma mais-valia para a compreensão do corpo humano, constituindo uma ferramenta relevante para a medicina moderna. Estas técnicas permitem não só o diagnóstico, como também a monitorização de doenças, sendo especialmente importantes na área neuro-oncológica. A ressonância magnética e a tomografia por emissão de positrões (MR e PET acrónimo inglês de Magnetic Ressonance e Positron Emission Tomography, respetivamente

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Wu, Cheng-Han, and 吳承翰. "Concurrent Anti-Vascular, Sonodynamic and Chemo Therapy in Solid Tumors by Superhydrophobic Dox-Loaded Nanoparticles." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/qu8f84.

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He, Yang Ma Teng. "Applications of small intestine submucosa in tumor model and vascular tissue engineering." 2004. http://etd.lib.fsu.edu/theses/available/etd-11122004-102425.

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Thesis (M.S.)--Florida State University, 2004.<br>Advisor: Dr. Teng Ma, Florida State University, College of Engineering, Dept. of Chemical and Biomedical Engineering. Title and description from dissertation home page (viewed Jan 12, 2005). Includes bibliographical references.

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"Endo-vascular Stenting for Abdominal Aortic Aneurysms with ‘Hostile’ Necks: A Computerized Evaluation of Neck Geometry." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292708.

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Siu, Hon Lam Elaine.<br>Thesis M.Phil. Chinese University of Hong Kong 2016.<br>Includes bibliographical references (leaves ).<br>Abstracts also in Chinese.<br>Title from PDF title page (viewed on …).

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"Functional magnetic resonance imaging: diffusion weighted and chemical shift imaging in head and neck." 2010. http://library.cuhk.edu.hk/record=b5894307.

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Fong, Kwan Ying.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves 90-103).<br>Abstracts in English and Chinese.<br>Chapter Chapter 1: --- "Introduction, problems and objectives" --- p.1<br>Chapter 1.1 --- Introduction --- p.1<br>Chapter 1.2 --- Problems --- p.3<br>Chapter 1.3 --- Objectives --- p.3<br>Chapter Chapter 2: --- Background --- p.4<br>Chapter 2.1. --- Head and Neck Cancer --- p.4<br>Chapter 2.2 --- Diagnostic Imaging of Head and Neck Cancer --- p.5<br>Chapter 2.3. --- Magnetic Resonance Imaging- Physics --- p.8<br>Ch

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Gill, Jason H., Paul M. Loadman, Steven D. Shnyder, et al. "Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity Against Solid Tumors and Reduced Potential For Cardiovascular Toxicity." 2014. http://hdl.handle.net/10454/8823.

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No<br>Development of therapeutic strategies for tumor-selective delivery of therapeutics through exploitation of the proteolytic tumor phenotype has significant scope for improvement of cancer treatment. ICT2588 is a peptide-conjugated prodrug of the vascular disrupting agent (VDA) azademethylcolchicine developed to be selectively hydrolyzed by matrix metalloproteinase-14 (MMP-14) within the tumor. In this report, we extend our previous proof-of-concept studies and demonstrate the therapeutic potential of this agent against models of human colorectal, lung, breast, and prostate cancer. In all

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Volz, Julia. "Studies on the influence of platelets on vascular integrity in primary tumors and the role of BIN2 in platelet calcium signaling." Doctoral thesis, 2020. https://doi.org/10.25972/OPUS-21742.

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Maintenance of tumor vasculature integrity is indispensable for tumor growth and thus affects tumor progression. Previous studies have identified platelets as major regulators of tumor vascular integrity, as their depletion selectively renders tumor vessels highly permeable, causing massive intratumoral hemorrhage. While these results establish platelets as potential targets for anti-tumor therapy, depletion is not a treatment option due to the essential role of platelets for hemostasis. This thesis demonstrates for the first time that functional inhibition of glycoprotein (GP) VI on the plate

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Hu, Fang-Yao. "Noninvasive Vascular Characterization with Low-cost, Label-free Optical Spectroscopy and Dark Field Microscopy Enables Head and Neck Cancer Diagnosis and Prognosis." Diss., 2016. http://hdl.handle.net/10161/13397.

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<p>Worldwide, head and neck squamous cell cancers (HNSCC) account for over 375,000 deaths annually. The majority of these cancers arise in the outermost squamous cells which progress through a series of precancerous changes before developing into invasive HNSCC. It is widely accepted that prognosis is strongly correlated to the stage of diagnosis, with early detection more than doubling the patient’s chance of survival. Currently, however, 60% of HNSCCs are diagnosed when they have already progressed to stage 3 or stage 4 disease. The current diagnostic method of visual examination often fails

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