Relevant bibliographies by topics / Vasorelaxant activity

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Vasorelaxant activity'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Vasorelaxant activity"

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Allam, Heba Abdelrasheed, Amr A. Kamel, Mahmoud El-Daly, and Riham F. George. "Synthesis and vasodilator activity of some pyridazin-3(2H)-one based compounds." Future Medicinal Chemistry 12, no. 1 (2020): 37–50. http://dx.doi.org/10.4155/fmc-2019-0160.

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Aim: Hypertension is a major health problem worldwide resulting in high death rates due to its consequences and complications. Therefore, searching for new vasorelaxants is a must to find new vasodilators efficient for the treatment of different cardiovascular diseases. Methodology: Different 6-phenyl-3-pyridazinone based derivatives were synthesized and screened for their vasorelaxant activity according to the reported method using hydralazine as a standard. Results: The tested compounds revealed potent to mild activity with EC50 values 0.339–114.300 μM compared with hydralazine EC50 = 18.210
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Jaroš, Filip, Tomáš Straka, Zdenka Dobešová, et al. "Vasorelaxant activity of some oxime derivatives." European Journal of Pharmacology 575, no. 1-3 (2007): 122–26. http://dx.doi.org/10.1016/j.ejphar.2007.07.040.

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Numan, N. A., M. N. Gillespie, and R. J. Altiere. "Pulmonary vasorelaxant activity of atrial peptides." Pulmonary Pharmacology 3, no. 1 (1990): 29–33. http://dx.doi.org/10.1016/0952-0600(90)90006-5.

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Jorge, Vergara-Galicia, Huerta-García Melina, Herrera-Chi Joaquín, et al. "Vasorelaxant Effect of Ethanolic Extracts from M. Vulgare: Mexican Medicinal Plant as Potential Source for Bioactive Molecules Isolation." Indo Global Journal of Pharmaceutical Sciences 03, no. 01 (2013): 01–05. http://dx.doi.org/10.35652/igjps.2013.01.

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To investigate vasorelaxant effect of ethanol extracts from M. vulgare, it is part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects. In this context, all extracts caused concentration-dependent relaxation in -precontracted aortic rings with and without endothelium; the most active extract was EERMv. These results suggest that secondary metabolites responsible for the vasorelaxant activity belong to
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Omonturdiev, S., D. Inomjonov, Abdullaev.A., et al. "STUDYING THE INFLUENCE OF QUERCETIN FLAVONOID ON CONTRACTILITY ACTIVITY OF RAT AORTIC SMOOTH MUSCLE CELLS." Norwegian Journal of development of the International Science, no. 112 (July 12, 2023): 8–13. https://doi.org/10.5281/zenodo.8146983.

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<strong>Abstract</strong> In this work, the vasorelaxant effect of the quercetine in isometric conditions on the smooth muscles of the rat aortic blood vessel has been studied. In experiments, it was obtained that &nbsp;the vasorelaxant effect of quercetine depends on its concentration and with blockade of CaL2+ &nbsp; &nbsp;- channels in the plasma membrane of smooth muscle cells of blood vessels.
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Pourová, Jana, Lenka Applová, Kateřina Macáková, et al. "The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo." Nutrients 11, no. 10 (2019): 2286. http://dx.doi.org/10.3390/nu11102286.

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Silymarin is a traditional drug and food supplement employed for numerous liver disorders. The available studies indicate that its activities may be broader, in particular due to claimed benefits in some cardiovascular diseases, but the contributions of individual silymarin components are unclear. Therefore, we tested silymarin flavonolignans as pure diastereomers as well as their sulfated metabolites for potential vasorelaxant and antiplatelet effects in isolated rat aorta and in human blood, respectively. Eleven compounds from a panel of 17 tested exhibited a vasorelaxant effect, with half m
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Hidalgo, Alam Yair, Nancy Romero-Ceronio, Carlos Ernesto Lobato-García, et al. "Position Matters: Effect of Nitro Group in Chalcones on Biological Activities and Correlation via Molecular Docking." Scientia Pharmaceutica 92, no. 4 (2024): 54. http://dx.doi.org/10.3390/scipharm92040054.

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A series of nine nitro group-containing chalcones were synthesized to investigate their anti-inflammatory and vasorelaxant activities via in vivo, ex vivo, and in silico studies. The anti-inflammatory effects of the compounds were evaluated via a TPA-induced mouse ear edema model, and the vasorelaxant effects were evaluated via an isolated organ model in addition to molecular docking studies. The compounds with the highest anti-inflammatory activity were 2 (71.17 ± 1.66%), 5 (80.77 ± 2.82%), and 9 (61.08 ± 2.06%), where the nitro group is located at the ortho position in both rings, as confirm
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Olmo, Esther del, Bianca Barboza, Ma Inés Ybarra, et al. "Vasorelaxant activity of phthalazinones and related compounds." Bioorganic & Medicinal Chemistry Letters 16, no. 10 (2006): 2786–90. http://dx.doi.org/10.1016/j.bmcl.2006.02.003.

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Vergara-Galicia, Jorge, Francisco Aguirre-Crespo, Patricia Castillo-España, et al. "Micropropagation and vasorelaxant activity ofLaelia autumnalis(Orchidaceae)." Natural Product Research 24, no. 2 (2010): 106–14. http://dx.doi.org/10.1080/14786410802340820.

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El-Ouady, Fadwa, and Mohamed Eddouks. "Asteriscus graveolens exhibits Antihypertensive Activity through Activation of Vascular KATP Channels Activation in Rats." Endocrine, Metabolic & Immune Disorders - Drug Targets 20, no. 5 (2020): 736–44. http://dx.doi.org/10.2174/1871530319666191016100851.

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Objective: The objective of the study was to evaluate the antihypertensive activity of Asteriscus graveolens. Methods: L-NAME hypertensive and normotensive rats have received orally the aqueous extract of Asteriscus graveolens aerial parts (AGAPE) (100 mg/kg) during six hours for the acute experiment and during seven days for the sub-chronic treatment. Thereafter, blood pressure parameters were evaluated. Concerning the in vitro investigation, the vasorelaxant effect of AGAPE was tested in isolated thoracic aortic rings. Results: AGAPE extract significantly decreased the blood pressure paramet
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Dissertations / Theses on the topic "Vasorelaxant activity"

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Brito, Teresinha Silva de. "VasodilataÃÃo causada pelo 1-nitro-2-feniletano em aorta de rato: provÃvel estimulaÃÃo da guanilato ciclase." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8535.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>Previamente, foi demonstrado que o tratamento via intravenosa com 1-nitro-2-feniletano (NFE) induziu hipotensÃo que resulta principalmente de sua aÃÃo vasodilatadora diretamente sobre o mÃsculo liso. Nesse estudo, estudamos o mecanismo subjacente ao efeito miorrelaxante do NFE em tecidos vasculares isolados de ratos. Registros isomÃtricos foram obtidos a partir de anÃis isolados de artÃria aorta e do segundo ramo da mesentÃrica de ratos atravÃs de sistema d
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LeitÃo, CÃntia CamurÃa Fernandes. "Structural and partial characterization of biological Two lectins do Gender Canavalia." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14952.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Lectins are proteins that bind carbohydrates specifically and reversibly. The legume lectins represent the best studied and established group, from the point of view of physical-chemical and biological and structural, where a well-studied group of these proteins involves lectin obtained from members of the subtribe Diocleinae. Lectins Diocleinae have a high degree of structural similarity, but the same was not true regarding biological activities. This variability, as a rule, is in the detail that can be analyzed in structures base
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Costa, Cintia Danieli Ferreira da. "Atividade vasorelaxante e anti-hipertensiva de LQM01, um novo derivado aminoguanidínico, em ratos espontaneamente hipertensos." Universidade Federal de Alagoas, 2017. http://www.repositorio.ufal.br/handle/riufal/1677.

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The literature reports beneficial effects of aminoguanidine and its derivatives on the cardiovascular system. This work utilized strategies of Medicinal Chemistry, such as molecular hybridization and bio-ossification, for the synthesis of 14 aromatic aminoguanidine derivatives (DAGs), in order to investigate effective, safe and less effective adverse therapeutic alternatives for the treatment of hypertension. After pharmacological screening with the 14 DAGs, in order to select the most efficient derivative with respect to its cytotoxic activity and vasorelaxant effect, the work follows with
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Tsai, Mei-Wen, and 蔡美雯. "Synthesis and Vasorelaxant Activity of 3- Substituted Benzopyrans." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/09657629702692207561.

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碩士<br>中國文化大學<br>應用化學研究所<br>88<br>ABSTRACT Ion channels, including sodium, calcium, and potassium channels, are present in all mammalian cells and play a major role in the control of a variety of physiological functions. Sodium channel blockers have been used for many years as local anesthetics (procaine and xylocaine) and antiarrhythmics (procainamide and lidocaine). Subsequently calcium channel blockers underwent a vigorous development and resulted in a number of drugs such as nifedipine and verapamil that are used in cardiovascular diseases. Currently there is an increasing int
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Simões, Daniela Sofia Matias. "Study of the vasorelaxant and antioxidant activity of Cymbopogon citratus." Master's thesis, 2019. http://hdl.handle.net/10316/88234.

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Dissertação de Mestrado em Farmacologia Aplicada apresentada à Faculdade de Farmácia<br>Cymbopogon citratus, Stapf, também conhecido como capim-limão, é uma planta que pertence à família Poaceac-Gramineae. É derivado da Índia, sendo atualmente cultivado em muitos países tropicais e subtropicais. É amplamente utilizado na medicina tradicional, devido aos potenciais efeitos antioxidantes, anti-inflamatórios, antimicrobianos, hipoglicemiantes e anti-hipertensores associados aos compostos bioativos da planta. Neste projeto de estudo pretendeu-se avaliar e comprovar a atividade vascular e antioxida
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Lin, Chung-Yin, and 林聰穎. "Synthesis and Vasorelaxant Activity of Naphthopyrans on Isolated Rat Thoracic Aorta." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/13148980448419198809.

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碩士<br>中國文化大學<br>應用化學研究所<br>88<br>Potassium channel openers, such as cromakalim, are potent smooth muscle relaxants which have been shown to have potential therapeutic application in a variety of cardiovascular and bronchopulmonary diseases, particularly in asthma, hypertension, and urinary incotinence. Cromakalim, the first benzopyran type potassium channel opener, was found as a potent antihypertensive agent in 1986. After that there have been numerous reports on modification of substituents at different positions of benzopyran ring, but few reports on modification of the benzopyran nucleus
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Book chapters on the topic "Vasorelaxant activity"

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Fitzpatrick, David F., Ronald G. Coffey, and Paul T. Jantzen. "Endothelium-Dependent Vasorelaxing Activity of Wine, Grapes, and Other Plant Products." In ACS Symposium Series. American Chemical Society, 1997. http://dx.doi.org/10.1021/bk-1997-0661.ch018.

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Arruda, Ray Ravilly Alves, Ulrich Vasconcelos, Rafael de Almeida Travassos, Tarcísio Tárcio Corrêa Bonifácio, Valdir de Andrade Braga, and Elisângela Afonso de Moura Kretzschmar. "Preparation and characterization of nanocapsules containing 2-nitrate and 1,3-diisobutoxypropane (NDIBP) nanocapsules and NDIBP/cyclodextrin inclusion complexes." In Multidisciplinary Perspectives: Integrating Knowledge. Seven Editora, 2024. http://dx.doi.org/10.56238/sevened2024.007-054.

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2-nitrate-1,3-diisobutoxypropane (NDIBP) is a synthetic organic nitrate derived from glycerin, with low solubility in water. The objective of this work was to prepare and characterize inclusion complexes and nanocapsules with NDIBP. The inclusion complexes were prepared by lyophilization and the nanocapsules by the preformed polymer interfacial deposition method. The solubility isotherms determined for NDIBP showed Al-type profiles (K1:1 = 33.0 M-1). The formation of the inclusion complex provided a 12.5-fold increase in the solubility of NDIBP. The inclusion complexes showed changes in crysta
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Taber, Douglass F. "The Carreira Synthesis of (+)-Daphmanidin E." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0092.

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(+)-Daphmanidin E 3, isolated from the leaves of Daphniphyllum teijsmanni, shows moderate vasorelaxant activity on the rat aorta. Considering the curiously compact structure of 3, Erick M. Carreira of ETH Zürich chose (Angew. Chem. Int. Ed. 2011, 50, 11501) to start the synthesis from the enantiomerically pure bicyclic diketone 2. The mono enolate of 2 was readily prepared, but the steric bulk of the ketal of 4 was needed to direct the subsequent hydroboration. Indeed, the alkene of 5 was so congested that excess BH3 at elevated temperature was required. Under those conditions, the esters were
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Carolina Cardoso-Teixeira, Ana, Klausen Oliveira-Abreu, Levy Gabriel de Freitas Brito, Andrelina Noronha Coelho-de-Souza, and José Henrique Leal-Cardoso. "Effects of Terpenes and Terpenoids of Natural Occurrence in Essential Oils on Vascular Smooth Muscle and on Systemic Blood Pressure: Pharmacological Studies and Perspective of Therapeutic Use." In Terpenes and Terpenoids [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94194.

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Terpenes are a class of chemical compounds with carbon and hydrogen atoms in their structure. They can be classified into several classes according to the quantity of isoprene units present in its structure. Terpenes can have their structure modified by the addition of various chemical radicals. When these molecules are modified by the addition of atoms other than carbon and hydrogen, they become terpenoids. Terpenes and terpenoids come from the secondary metabolism of several plants. They can be found in the leaves, fruits, stem, flowers, and roots. The concentration of terpenes and terpenoid
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