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Journal articles on the topic 'Vasorelaxant activity'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Allam, Heba Abdelrasheed, Amr A. Kamel, Mahmoud El-Daly, and Riham F. George. "Synthesis and vasodilator activity of some pyridazin-3(2H)-one based compounds." Future Medicinal Chemistry 12, no. 1 (2020): 37–50. http://dx.doi.org/10.4155/fmc-2019-0160.

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Aim: Hypertension is a major health problem worldwide resulting in high death rates due to its consequences and complications. Therefore, searching for new vasorelaxants is a must to find new vasodilators efficient for the treatment of different cardiovascular diseases. Methodology: Different 6-phenyl-3-pyridazinone based derivatives were synthesized and screened for their vasorelaxant activity according to the reported method using hydralazine as a standard. Results: The tested compounds revealed potent to mild activity with EC50 values 0.339–114.300 μM compared with hydralazine EC50 = 18.210

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2

Jaroš, Filip, Tomáš Straka, Zdenka Dobešová, et al. "Vasorelaxant activity of some oxime derivatives." European Journal of Pharmacology 575, no. 1-3 (2007): 122–26. http://dx.doi.org/10.1016/j.ejphar.2007.07.040.

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3

Numan, N. A., M. N. Gillespie, and R. J. Altiere. "Pulmonary vasorelaxant activity of atrial peptides." Pulmonary Pharmacology 3, no. 1 (1990): 29–33. http://dx.doi.org/10.1016/0952-0600(90)90006-5.

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4

Jorge, Vergara-Galicia, Huerta-García Melina, Herrera-Chi Joaquín, et al. "Vasorelaxant Effect of Ethanolic Extracts from M. Vulgare: Mexican Medicinal Plant as Potential Source for Bioactive Molecules Isolation." Indo Global Journal of Pharmaceutical Sciences 03, no. 01 (2013): 01–05. http://dx.doi.org/10.35652/igjps.2013.01.

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To investigate vasorelaxant effect of ethanol extracts from M. vulgare, it is part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects. In this context, all extracts caused concentration-dependent relaxation in -precontracted aortic rings with and without endothelium; the most active extract was EERMv. These results suggest that secondary metabolites responsible for the vasorelaxant activity belong to

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5

Omonturdiev, S., D. Inomjonov, Abdullaev.A., et al. "STUDYING THE INFLUENCE OF QUERCETIN FLAVONOID ON CONTRACTILITY ACTIVITY OF RAT AORTIC SMOOTH MUSCLE CELLS." Norwegian Journal of development of the International Science, no. 112 (July 12, 2023): 8–13. https://doi.org/10.5281/zenodo.8146983.

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<strong>Abstract</strong> In this work, the vasorelaxant effect of the quercetine in isometric conditions on the smooth muscles of the rat aortic blood vessel has been studied. In experiments, it was obtained that  the vasorelaxant effect of quercetine depends on its concentration and with blockade of CaL2+    - channels in the plasma membrane of smooth muscle cells of blood vessels.

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Pourová, Jana, Lenka Applová, Kateřina Macáková, et al. "The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo." Nutrients 11, no. 10 (2019): 2286. http://dx.doi.org/10.3390/nu11102286.

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Silymarin is a traditional drug and food supplement employed for numerous liver disorders. The available studies indicate that its activities may be broader, in particular due to claimed benefits in some cardiovascular diseases, but the contributions of individual silymarin components are unclear. Therefore, we tested silymarin flavonolignans as pure diastereomers as well as their sulfated metabolites for potential vasorelaxant and antiplatelet effects in isolated rat aorta and in human blood, respectively. Eleven compounds from a panel of 17 tested exhibited a vasorelaxant effect, with half m

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Hidalgo, Alam Yair, Nancy Romero-Ceronio, Carlos Ernesto Lobato-García, et al. "Position Matters: Effect of Nitro Group in Chalcones on Biological Activities and Correlation via Molecular Docking." Scientia Pharmaceutica 92, no. 4 (2024): 54. http://dx.doi.org/10.3390/scipharm92040054.

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A series of nine nitro group-containing chalcones were synthesized to investigate their anti-inflammatory and vasorelaxant activities via in vivo, ex vivo, and in silico studies. The anti-inflammatory effects of the compounds were evaluated via a TPA-induced mouse ear edema model, and the vasorelaxant effects were evaluated via an isolated organ model in addition to molecular docking studies. The compounds with the highest anti-inflammatory activity were 2 (71.17 ± 1.66%), 5 (80.77 ± 2.82%), and 9 (61.08 ± 2.06%), where the nitro group is located at the ortho position in both rings, as confirm

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8

Olmo, Esther del, Bianca Barboza, Ma Inés Ybarra, et al. "Vasorelaxant activity of phthalazinones and related compounds." Bioorganic & Medicinal Chemistry Letters 16, no. 10 (2006): 2786–90. http://dx.doi.org/10.1016/j.bmcl.2006.02.003.

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9

Vergara-Galicia, Jorge, Francisco Aguirre-Crespo, Patricia Castillo-España, et al. "Micropropagation and vasorelaxant activity ofLaelia autumnalis(Orchidaceae)." Natural Product Research 24, no. 2 (2010): 106–14. http://dx.doi.org/10.1080/14786410802340820.

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10

El-Ouady, Fadwa, and Mohamed Eddouks. "Asteriscus graveolens exhibits Antihypertensive Activity through Activation of Vascular KATP Channels Activation in Rats." Endocrine, Metabolic & Immune Disorders - Drug Targets 20, no. 5 (2020): 736–44. http://dx.doi.org/10.2174/1871530319666191016100851.

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Objective: The objective of the study was to evaluate the antihypertensive activity of Asteriscus graveolens. Methods: L-NAME hypertensive and normotensive rats have received orally the aqueous extract of Asteriscus graveolens aerial parts (AGAPE) (100 mg/kg) during six hours for the acute experiment and during seven days for the sub-chronic treatment. Thereafter, blood pressure parameters were evaluated. Concerning the in vitro investigation, the vasorelaxant effect of AGAPE was tested in isolated thoracic aortic rings. Results: AGAPE extract significantly decreased the blood pressure paramet

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11

IIZUKA, Toru, Hiroko FUNAYAMA, Genjiro KUSANO, and Masahiro NAGAI. "Vasorelaxant Activity of N-Caffeoylamino Acids." YAKUGAKU ZASSHI 123, no. 11 (2003): 963–71. http://dx.doi.org/10.1248/yakushi.123.963.

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12

Taka, Naoki, Hiroshi Koga, Haruhiko Sato, Takenori Ishizawa, Tadakatsu Takahashi, and Jun-ichi Imagawa. "Vasorelaxant activity of 2-fluoromethylbenzopyran K+ channel openers." Bioorganic & Medicinal Chemistry Letters 4, no. 24 (1994): 2893–98. http://dx.doi.org/10.1016/s0960-894x(01)80835-0.

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13

Zaima, Kazumasa, Ikumi Koga, Nobuhide Iwasawa, et al. "Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma." Journal of Natural Medicines 67, no. 1 (2012): 9–16. http://dx.doi.org/10.1007/s11418-012-0638-y.

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14

Yeh, Jwu-Lai, Tzu-Hsin Yang, Jhy-Chong Liang, et al. "Isoeugenodilol: A vasorelaxant ?/?-adrenoceptor blocker with antioxidant activity." Drug Development Research 51, no. 1 (2000): 29–42. http://dx.doi.org/10.1002/1098-2299(20000901)51:1<29::aid-ddr4>3.0.co;2-2.

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15

Akdad, Mourad, Mohammed Ajebli, Andrea Breuer, Farid Khallouki, Robert W. Owen, and Mohamed Eddouks. "Study of Antihypertensive Activity of Anvillea radiata in L-Name-Induced Hypertensive Rats and HPLC-ESI-MS Analysis." Endocrine, Metabolic & Immune Disorders - Drug Targets 20, no. 7 (2020): 1059–72. http://dx.doi.org/10.2174/1871530319666191115114023.

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Objective: This study aimed to evaluate the effect of the aqueous extract of Anvillea radiate (A. radiata) aerial parts (AEAR) on arterial blood pressure in normotensive and hypertensive rats. Methods: The effect of the acute and sub-chronic administration of AEAR on the following blood pressure parameters: systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP), and heart rate (HR) was evaluated in normotensive and L-NAME induced hypertensive rats. In the second experiment, the vasorelaxant effect of AEAR was assessed in isolated aortic rings from rats with fu

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16

Zaripov, Abdisalim A., Inoyat Z. Zhumaev, Pulat B. Usmanov, et al. "Mechanism of Vasorelaxant Action of Isoquinoline Alkaloid F-19 on Rat Aorta." Biomedical and Pharmacology Journal 18, no. 2 (2025): 1601–10. https://doi.org/10.13005/bpj/3195.

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The development of cardiovascular diseases is primarily associated with impaired activity of ion transport systems that ensure Ca2+ homeostasis in vascular smooth muscle cells. Modulation of the function of Ca2+ ion transport systems in smooth muscle cells with biologically active compounds allows the development of new approaches to the pharmacological regulation of Ca2+-dependent processes in cardiovascular diseases. This article studies the mechanisms of the vasorelaxant effect of the isoquinoline alkaloid 1-(3¢-Bromo-4¢-hydroxyphenyl-5¢-methoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoqui

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17

Woodman, Owen L., William F. Meeker, and Mirna Boujaoude. "Vasorelaxant and Antioxidant Activity of Flavonols and Flavones: Structure-Activity Relationships." Journal of Cardiovascular Pharmacology 46, no. 3 (2005): 302–9. http://dx.doi.org/10.1097/01.fjc.0000175431.62626.07.

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18

Zhao, Hong, John Quilley, David C. Montrose, Swarna Rajagopalan, Qizhi Guan, and Carolyn J. Smith. "Differential effects of phosphodiesterase PDE-3/PDE-4-specific inhibitors on vasoconstriction and cAMP-dependent vasorelaxation following balloon angioplasty." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 6 (2007): H2973—H2981. http://dx.doi.org/10.1152/ajpheart.00419.2006.

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It is known that cAMP and cGMP are important for vasorelaxation, and cyclic nucleotide phosphodiesterases (PDEs) regulate their levels. Balloon angioplasty (BAL) is associated with reduced cAMP and cGMP levels, and inhibition of PDE-3 reduces restenosis. In this study, we found that BAL increased PDE-3 activity, which affected vasoreactivity of rat aortic rings 24-h post-BAL; these were compared with intact (INT) and ex vivo endothelium-denuded rings (RUB) from sham rats. In BAL and RUB rings, vasorelaxant responses to ACh were abolished. The EC50 for phenylephrine (PE) was 1.8-fold less in RU

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19

Yam, Mun Fei, Chu Shan Tan, Mariam Ahmad, and Shibao Ruan. "Vasorelaxant Action of the Chloroform Fraction of Orthosiphon stamineus via NO/cGMP Pathway, Potassium and Calcium Channels." American Journal of Chinese Medicine 44, no. 07 (2016): 1413–39. http://dx.doi.org/10.1142/s0192415x16500798.

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Orthosiphon stamineus Benth. (Lamiaceae) is an important plant in traditional folk medicine that is used to treat hypertension and kidney stones. In humans, this plant has been tested as an addition regiment for antihypertensive treatment. Among the treatments for hypertension, O. stamineus had been to have diuretic and vasorelaxant effects in animal models. There is still very little information regarding the vasorelaxant effect of O. stamineus. Therefore, the present study was designed to investigate the vasorelaxant activity and mechanism of action of the fractions of O. stamineus. The vaso

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20

Kumar, Dinesh, Rosalia Carron, Carmen La Calle, Dharam Jindal, and Ranju Bansal. "Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators." Acta Pharmaceutica 58, no. 4 (2008): 393–405. http://dx.doi.org/10.2478/v1007-008-0021-4.

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Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilatorsThe present study describes the synthesis and pharmacological evaluation of 2-substituted-6-(4-acylaminophenyl)-4,5-dihydropyridazin-3(2H)-ones as potent inodilating agents. The synthesis of target compounds2-4and7-11was achieved by Friedel-Crafts acylation of appropriate anilide derivative with succinic anhydride or methylsuccinic anhydride and subsequent cyclization of intermediary keto acids with various hydrazine derivatives. The newly synthesized pyridazinone derivatives were evaluated

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21

Zhang, Sheng-Yuan, Zi-Wei Li, Jie Xu, Qiu-Ling Chen, Min Song, and Qing-Wen Zhang. "Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities." Molecules 26, no. 23 (2021): 7191. http://dx.doi.org/10.3390/molecules26237191.

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Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and circular dichroism experiments. All the compounds were evaluated for their vasorelaxant and acetylcholinesterase (AChE) inhibitory activities. Compound 1 exhibited potent vasorelaxant activity, with an EC50 value of 8.7 μM, and compounds 2 and 3 showed moderate acetylcholinesterase (AChE) inhibitory a

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22

Davis, Alison J., Jian Shi, Harry AT Pritchard, et al. "Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01." British Journal of Pharmacology 168, no. 3 (2013): 773–84. http://dx.doi.org/10.1111/j.1476-5381.2012.02199.x.

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23

Abouzid, Khaled, Maha Abdel Hakeem, Omnya Khalil, and Yosria Maklad. "Pyridazinone derivatives: Design, synthesis, and in vitro vasorelaxant activity." Bioorganic & Medicinal Chemistry 16, no. 1 (2008): 382–89. http://dx.doi.org/10.1016/j.bmc.2007.09.031.

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24

Yap, Suwan, Karen J Loft, Owen L Woodman, and Spencer J Williams. "Discovery of Water-Soluble Antioxidant Flavonols without Vasorelaxant Activity." ChemMedChem 3, no. 10 (2008): 1572–79. http://dx.doi.org/10.1002/cmdc.200800146.

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25

Lee, Kyungjin, Geunyong Park, Inhye Ham, et al. "Vasorelaxant Effect of Osterici Radix Ethanol Extract on Rat Aortic Rings." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/350964.

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The root ofOstericum koreanumMaximowicz has been used as a traditional medicine called “Kanghwal” in Korea (or “Qianghuo” in China). The purpose of this study was to investigate the vasorelaxant activity and mechanism of action of an ethanol extract of theO. koreanumroot (EOK). We used isolated rat aortic rings to assess the effects of EOK on various vasorelaxant or vasoconstriction factors. EOK induced vasorelaxation in phenylephrine hydrochloride (PE) or KCl precontracted aortic rings in a concentration-dependent manner. However, the vasorelaxant effects of EOK on endothelium-intact aortic r

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26

Wróbel-Biedrawa, Dagmara, Monika Kubacka, Magdalena Kotańska, Marek Bednarski, Karolina Grabowska, and Irma Podolak. "Comparative Evaluation of Vasorelaxant and Antiplatelet Activity of Two Plant-Derived Benzoquinones: Rapanone and Embelin." Molecules 30, no. 4 (2025): 845. https://doi.org/10.3390/molecules30040845.

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Vasorelaxant and antiplatelet agents play an important role in preventing and combating endothelial dysfunction, atherosclerosis and a plethora of associated cardiovascular diseases (CVDs). CVDs are the leading cause of death worldwide and nowadays occur not only in developed but also in developing societies. They include, among others, coronary heart disease, cerebrovascular disease and peripheral artery disease. Due to their high prevalence, it is important to seek efficient preventive measures, such as lifestyle changes and the implementation of appropriate herbal dietary supplementation an

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Pozzetti, Luca, Francesca Ferrara, Ludovica Marotta, et al. "Extra Virgin Olive Oil Extracts of Indigenous Southern Tuscany Cultivar Act as Anti-Inflammatory and Vasorelaxant Nutraceuticals." Antioxidants 11, no. 3 (2022): 437. http://dx.doi.org/10.3390/antiox11030437.

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Extra virgin olive oil (EVOO) is the typical source of fats in the Mediterranean diet. While fatty acids are essential for the EVOO nutraceutical properties, multiple biological activities are also due to the presence of polyphenols. In this work, autochthonous Tuscany EVOOs were chemically characterized and selected EVOO samples were extracted to obtain hydroalcoholic phytocomplexes, which were assayed to establish their anti-inflammatory and vasorelaxant properties. The polar extracts were characterized via 1H-NMR and UHPLC-HRMS to investigate the chemical composition and assayed in CaCo-2 c

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Baccelli, Chiara, Ismael Navarro, Sébastien Block, Antonio Abad, Nicole Morel, and Joëlle Quetin-Leclercq. "Vasorelaxant Activity of Diterpenes fromCrotonzambesicusand Synthetic Trachylobanes and Their Structure−Activity Relationships." Journal of Natural Products 70, no. 6 (2007): 910–17. http://dx.doi.org/10.1021/np0603976.

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Jorge, Vergara-Galicia, Jimenez-Ramirez Luis Ángel, Tun-Suarez Adrián, et al. "Vasorelaxant activity of extracts obtained from Apium graveolens: Possible source for vasorelaxant molecules isolation with potential antihypertensive effect." Asian Pacific Journal of Tropical Biomedicine 3, no. 10 (2013): 776–79. http://dx.doi.org/10.1016/s2221-1691(13)60154-9.

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Nguelefack-Mbuyo, Elvine Pami, Alain Bertrand Dongmo, Télesphore Benoît Nguelefack, Albert Kamanyi, Pierre Kamtchouing, and Théophile Dimo. "Endothelium/Nitric Oxide Mediates the Vasorelaxant and Antihypertensive Effects of the Aqueous Extract from the Stem Bark ofMammea africanaSabine (Guttiferae)." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/961741.

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This study evaluates the vasorelaxant and antihypertensive effects of the aqueous extract from the stem bark ofM. africana(AEMA). AEMA was testedin vitroon intact or endothelium-denuded rats’ aorta rings precontracted with KCl or norepinephrine in absence or in presence of L-NAME or glibenclamide. The effect of a single concentration (300 μg/mL) of AEMA was also examined on the concentration-response curve of KCl.In vivo, the antihypertensive effects of AEMA (200 mg/kg/day) were evaluated in male Wistar rats treated with L-NAME (40 mg/kg/day) for 4 weeks. AEMA relaxed aorta rings precontracted

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Aguilar-Guadarrama, A. Berenice, Guadalupe Yáñez-Ibarra, Martha Edith Cancino-Marentes, et al. "Chromatographic Techniques and Pharmacological Analysis as a Quality Control Strategy for Serjania triquetra a Traditional Medicinal Plant." Pharmaceuticals 15, no. 10 (2022): 1289. http://dx.doi.org/10.3390/ph15101289.

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Serjania triquetra is a medicinal plant widely used in traditional medicine for the treatment of urinary tract diseases, renal affections, and its complications. The population can buy this plant in folk markets as a raw material mixed with several herbal remedies or as a health supplement. On the market, two commercial presentations were found for the vegetal material; one had a bulk appearance and the other was marketed wrapped in cellophane bags (HESt-2, HESt-3). Nevertheless, the plant has not been exhaustively investigated and quality control techniques have not been developed. This resea

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Adhikari, Deepak, Dal-Seong Gong, Se Hee Oh, et al. "Vasorelaxant Effect of Boesenbergia rotunda and Its Active Ingredients on an Isolated Coronary Artery." Plants 9, no. 12 (2020): 1688. http://dx.doi.org/10.3390/plants9121688.

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Cardiovascular diseases are a major cause of death in developed countries. The regulation of vascular tone is a major approach to prevent and ameliorate vascular diseases. As part of our ongoing screening for cardioprotective natural compounds, we investigated the vasorelaxant effect of rhizomes from Boesenbergia rotunda (L.) Mansf. [Boesenbergia pandurata (Roxb.) Schltr.] used as a spice and herbal medicine in Asian countries. The methanol extract of B. rotunda rhizomes (BRE) exhibited significant vasorelaxation effects ex vivo at EC50 values of 13.4 ± 6.1 μg/mL and 40.9 ± 7.9 μg/mL, respecti

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Amssayef, Ayoub, and Mohamed Eddouks. "Aqueous Extract of Matricaria pubescens Exhibits Antihypertensive Activity in L-NAME-induced Hypertensive Rats through its Vasorelaxant Effect." Cardiovascular & Hematological Agents in Medicinal Chemistry 17, no. 2 (2019): 135–43. http://dx.doi.org/10.2174/1871525717666191007151413.

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Background: Matricaria pubescens is a medicinal plant from North Africa. This plant is widely used in alternative medicine as a remedy against rheumatism, inflammation, diabetes and hypertension. Aim: The aim of the study was to evaluate the possible antihypertensive and vasodilator activity of the aqueous extract of Matricaria pubescens (M. pubescens). Material and Methods: In the current study, the aqueous extract of the aerial parts of M. pubescens (AEMP) was prepared and its antihypertensive activity was examined in N(ω)-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Res

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Mobin, Mitra, Sidney G. de Lima, Lorena T. G. Almeida, et al. "Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil fromProtium heptaphyllum(Aubl.) March." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/1928171.

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TheProtium heptaphyllumspecies, also known as Almécega, produces an oily resin, used in folk medicine as an analgesic and anti-inflammatory agent, in healing, and as an expectorant, which is rich in pentacyclic triterpenes and essential oils. In this study, the essential oil obtained by hydrodistillation of Almécega’s resin was analyzed by gas chromatography-triple quadrupole mass spectrometry and evaluated for chemical composition and vasorelaxant activity in rat superior mesenteric artery. The main constituents determined by gas chromatography-triple quadrupole mass spectrometry were limonen

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El Bardai, Sanae, Nicole Morel, Maurice Wibo, et al. "The Vasorelaxant Activity of Marrubenol and Marrubiin from Marrubium vulgare." Planta Medica 69, no. 01 (2003): 75–77. http://dx.doi.org/10.1055/s-2003-37042.

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Zhang, Jian, Zhi-Wen Liu, Yong Li, et al. "Structurally Diverse Indole Alkaloids with Vasorelaxant Activity from Melodinus hemsleyanus." Journal of Natural Products 83, no. 8 (2020): 2313–19. http://dx.doi.org/10.1021/acs.jnatprod.9b00925.

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Takahashi, Tadakatsu, Hiroshi Koga, Haruhiko Sato, Takenori Ishizawa, Naoki Taka, and Jun-ichi Imagawa. "Synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers." Bioorganic & Medicinal Chemistry 6, no. 3 (1998): 323–37. http://dx.doi.org/10.1016/s0968-0896(97)10035-9.

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Campos-Toimil, Manuel, Francisco Orallo, Lourdes Santana, and Eugenio Uriarte. "Synthesis and Vasorelaxant Activity of New Coumarin and Furocoumarin Derivatives." Bioorganic & Medicinal Chemistry Letters 12, no. 5 (2002): 783–86. http://dx.doi.org/10.1016/s0960-894x(02)00015-x.

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Morita, Hiroshi, Toru Iizuka, Chee-Yan Choo, Kit-Lam Chan, Koichi Takeya, and Jun’ichi Kobayashi. "Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa." Bioorganic & Medicinal Chemistry Letters 16, no. 17 (2006): 4609–11. http://dx.doi.org/10.1016/j.bmcl.2006.06.008.

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Penso, Juliana, Kelly C. F. A. Cordeiro, Carla R. M. da Cunha та ін. "Vasorelaxant activity of 7-β-O-glycosides biosynthesized from flavonoids". European Journal of Pharmacology 733 (червень 2014): 75–80. http://dx.doi.org/10.1016/j.ejphar.2014.03.014.

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Barroso-Neto, Ito Liberato, Rafael Conceição Simões, Bruno Anderson Matias Rocha, et al. "Vasorelaxant activity of Canavalia grandiflora seed lectin: A structural analysis." Archives of Biochemistry and Biophysics 543 (February 2014): 31–39. http://dx.doi.org/10.1016/j.abb.2013.12.006.

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Subhan, Zakia, Niaz Ali, Abid Ullah, Wajid Ali, Muhammad Nabi та Syed Wadood Ali Shah. "New Lead Schiff Bases Predominantly Mediate Vasorelaxant Activity Through α1 Receptor Blocking Activity". Biomolecules 15, № 5 (2025): 611. https://doi.org/10.3390/biom15050611.

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Schiff bases synthesized in our laboratory have demonstrated pain-relieving effects through both peripheral and central nervous system pathways. Considering that centrally acting analgesics often affect the muscle tone of the gastrointestinal tract (GIT) and related deep internal organs, this study was conducted to examine potential relaxant effects on blood vessels and GIT smooth muscles. The possible relaxant effects of Schiff bases (SB1 and SB2) on isolated rabbit aortic strips were evaluated. The experiments involved assessing their impact on contractions induced by 80 mM potassium chlorid

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Wu, Dan, Qingxun Hu, Fenfen Ma, and Yi Zhun Zhu. "Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/7075682.

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Endothelium-dependent vasorelaxant injury leads to a lot of cardiovascular diseases. Both hydrogen sulfide (H2S) and nitric oxide (NO) are gasotransmitters, which play a critical role in regulating vascular tone. However, the interaction between H2S and NO in vasorelaxation is still unclear. ZYZ-803 was a novel H2S and NO conjugated donor developed by H2S-releasing moiety (S-propyl-L-cysteine (SPRC)) and NO-releasing moiety (furoxan). ZYZ-803 could time- and dose-dependently relax the sustained contraction induced by PE in rat aortic rings, with potencies of 1.5- to 100-fold greater than that

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Varma, Daya R., Xing-Fei Deng, Sylvain Chemtob, Francois Nantel, and Michel Bouvier. "Characterization of the vasorelaxant activity of tyramine and other phenylethylamines in rat aorta." Canadian Journal of Physiology and Pharmacology 73, no. 6 (1995): 742–46. http://dx.doi.org/10.1139/y95-097.

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We recently reported that tyramine caused concentration-dependent relaxation of rat aorta, which was endothelium independent and was not exerted via α1-adrenoceptors (AR), α2AR, β1AR, β2AR, or receptors for 5-hydroxytryptamine, histamine, and adenosine. The present studies were done on endothelium-denuded strips to determine structure – vasorelaxant activity after blockade of βAR by propranolol plus irreversible blockade of α1AR with benextramine. Vasorelaxation under these conditions was limited to noncatecholamines, and their vasorelaxant potencies were methoxyphenamine > tyramine > p-

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Morita, Hiroshi, Yuichiro Tomizawa, Jun Deguchi, et al. "Synthesis and structure–activity relationships of cassiarin A as potential antimalarials with vasorelaxant activity." Bioorganic & Medicinal Chemistry 17, no. 24 (2009): 8234–40. http://dx.doi.org/10.1016/j.bmc.2009.10.013.

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Munín, Javier, Elías Quezada, Andrea Cuiñas, et al. "Synthesis, biological evaluation and structure–activity relationships of new phthalazinedione derivatives with vasorelaxant activity." European Journal of Medicinal Chemistry 82 (July 2014): 407–17. http://dx.doi.org/10.1016/j.ejmech.2014.05.052.

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Evaristo Rodrigues da Silva, Renata, Andressa de Alencar Silva, Luís Pereira-de-Morais, et al. "Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels." Molecules 25, no. 11 (2020): 2681. http://dx.doi.org/10.3390/molecules25112681.

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Carveol is a monoterpene present in the structure of many plant products. It has a variety of biological activities: antioxidant, anticancer and vasorelaxation. However, studies investigating the effect of monoterpenoids on human vessels have not yet been described. Thus, the present study aimed to characterize the effect of (−)-carveol on human umbilical arteries (HUAs). HUA ring preparations were isolated and subjected to isometric tension recordings of umbilical artery smooth muscle contractions. (−)-Carveol exhibited a significant vasorelaxant effect on KCl and 5-HT-induced contractions, o

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Raoelison, Guy E., Mamy H. Rafamantanana, René Razafindrazaka, et al. "Vasorelaxant Alkaloids from Spirospermum penduliflorum (Menispermaceae), a Plant Used to Treat Hypertension in Malagasy Traditional Medicine." Natural Product Communications 8, no. 5 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800506.

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Spirospermum penduliflorum Thouars (Menispermaceae) is widely used on the eastern coast of Madagascar to treat hypertension. The aim of the present study was to analyse the vasorelaxant properties of different leaf extracts. The activity of the n-hexane, dichloromethane and methanolic extracts was tested on phenylephrine-contracted aorta. The dichloromethane extract was shown to be the most effective. Further fractionation of this extract led to the isolation of an active fraction relaxing phenylephrine-contracted aorta with an IC50 of 0.18 μg/mL {log IC50 (μg/mL) −0.74 ± 0.03} but was much le

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Aguirre Crespo, FranciscoJavier, EliasCerino Pérez, JaniceD G. Valdovinos Estrella, et al. "Vasorelaxant and antioxidant activity of some medicinal plants from Campeche, Mexico." Pharmacognosy Magazine 17, no. 73 (2021): 23. http://dx.doi.org/10.4103/pm.pm_291_20.

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Brimble, Margaret A., Victoria J. Muir, Brian Hopkins, and Sergio Bova. "Synthesis and evaluation of vasoconstrictor and vasorelaxant activity of norbormide isomers." Arkivoc 2004, no. 1 (2004): 1–11. http://dx.doi.org/10.3998/ark.5550190.0005.101.

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