Log in

Relevant bibliographies by topics / Vcasan / Journal articles

To see the other types of publications on this topic, follow the link: Vcasan.

Journal articles on the topic 'Vcasan'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Vcasan.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

WADA, Tomotaka, Shinji NAKAI, Tetsuya MARUOKA, Haokun WANG, and Hiromi OKADA. "Mobile Terminal Substitution of Vehicular Collision Avoidance Support System (VCASS) for Non-VCASS Vehicles: S-VCASS." IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences E94-A, no. 1 (2011): 410–19. http://dx.doi.org/10.1587/transfun.e94.a.410.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Melstrom, Richard T. "A Note on the Petroleum Industry's Participation in Conservation Agreements for the Lesser Prairie Chicken." Agricultural and Resource Economics Review 48, no. 1 (2018): 100–116. http://dx.doi.org/10.1017/age.2018.20.

Full text

Abstract:

This paper examines the petroleum industry's willingness to participate in conservation agreements for the lesser prairie chicken, a candidate for listing under the Endangered Species Act (ESA). Voluntary conservation agreements with assurances (VCAAs) can incentivize habitat conservation and sustain economic development. Using data on oil and natural gas wells in Kansas and Oklahoma, I develop a discrete choice model to examine company preferences for locating wells and participating in VCAAs for the lesser prairie chicken. Participation in VCAAs is low, but I find participating wells are con

APA, Harvard, Vancouver, ISO, and other styles

3

LEE, Dongwoo, Changwoo MIN, and Young IK EOM. "vCanal: Paravirtual Socket Library towards Fast Networking in Virtualized Environment." IEICE Transactions on Information and Systems E99.D, no. 2 (2016): 360–69. http://dx.doi.org/10.1587/transinf.2015edp7224.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Zhang, Qi, Junxiu Wu, Xinpeng Chen, Ming Zhao, Dahong Zhang, and Feng Gao. "Upregulation of Versican Associated with Tumor Progression, Metastasis, and Poor Prognosis in Bladder Carcinoma." BioMed Research International 2021 (February 2, 2021): 1–11. http://dx.doi.org/10.1155/2021/6949864.

Full text

Abstract:

Objective. This work analyzes the role of versican (VCAN) on bladder cancer (BLCA). Versican (VCAN) is a chondroitin sulfate proteoglycan which is important for tumorigenesis and the development of cancer. However, the expression of VCAN on human bladder cancer (BLCA) has been rarely reported. Methods. The clinical significance of VCAN in BLCA has been determined by our bioinformatics tools. Then, we performed immunohistochemical staining (IHC) and analyzed the correlation between VCAN expression and clinicopathological features. Results. The bioinformatics results reveal that a high VCAN mRNA

APA, Harvard, Vancouver, ISO, and other styles

5

Emmerich, Philip B., Tonela Qyli, Katherine A. Johnson, et al. "Stromal Versican Accumulation and Proteolysis Regulate the Infiltration of CD8+ T Cells in Breast Cancer." Cancers 17, no. 9 (2025): 1435. https://doi.org/10.3390/cancers17091435.

Full text

Abstract:

Background/Objectives: Recent clinical trials in breast cancer have demonstrated that some patients benefit from immune checkpoint blockade, though better predictive markers are needed. The accumulation of the immunomodulatory matrix proteoglycan versican (VCAN) can predict the exclusion of CD8+ tumor-infiltrating lymphocytes (TILs) in some settings and, thus, is evaluated in breast cancer here. Methods: A total of 230 breast cancers were analyzed for VCAN accumulation, VCAN proteolysis, and CD8+ TILs. CD8+ TILs were categorized based on their localization in the tumor epithelial or stromal co

APA, Harvard, Vancouver, ISO, and other styles

6

Sun, Zhao, Heli Gao, Junjie Gu, Yuejuan Cheng, Yuanjia Chen, and Chunmei Bai. "The expression of versican and its role in pancreatic neuroendocrine tumors." Journal of Clinical Oncology 36, no. 4_suppl (2018): 254. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.254.

Full text

Abstract:

254 Background: Pancreatic neuroendocrine tumor (pNET) is a group of rare and heterogeneous tumor. Prognostic biomarkers are essential to better predict patients’ prognosis and approve individualized chemotherapy. According to references, Versican(VCAN) expression plays an important role in the development of various tumors.Our previous study found VCAN had a tumor-specific expression in pNET tissues. Therefore, further study is performed to investigate the relationship between VCAN expression in pNET tissues and patients’ prognosis. Methods: Clinicopathological data of pNET patients who under

APA, Harvard, Vancouver, ISO, and other styles

7

Emmerich, Philip, Kristina A. Matkowskyj, Stephanie McGregor, et al. "VCAN accumulation and proteolysis as predictors of T lymphocyte-excluded and permissive tumor microenvironments." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3127. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3127.

Full text

Abstract:

3127 Background: Immune checkpoint inhibitors (ICIs) represent a major advance for treating solid tumors. However, only a minority of patients (pts) benefit from these therapies and markers that predict response have been elusive. Versican (VCAN) is an immunosuppressive proteoglycan in the tumor microenvironment (TME), which releases an immunostimulatory N-terminal fragment versikine (Vkine) when cleaved by ADAMTS proteases. We have demonstrated in colorectal cancers (CRC) that a low VCAN/high Vkine (VCAN proteolytic predominant [VPP]) phenotype correlates with increased tumor-infiltrating CD8

APA, Harvard, Vancouver, ISO, and other styles

8

Kraus, Sean G., Anna Field, Derek Buckalew, Cheri Pasch, and Dustin Deming. "Abstract B34: Versican accumulation and proteolysis differentially predict T cell subset abundance within the colorectal cancer tumor microenvironment." Cancer Immunology Research 10, no. 12_Supplement (2022): B34. http://dx.doi.org/10.1158/2326-6074.tumimm22-b34.

Full text

Abstract:

Abstract Introduction: The purpose of this study is to correlate T cell subset abundance with the accumulation and proteolysis of versican (VCAN) in colorectal cancer (CRC). Background: In CRC, VCAN accumulation is associated with the exclusion of CD8+ tumor infiltrating lymphocytes (TILs) and its proteolysis, into versikine (Vkine), correlates with increased TIL abundance. Here we additionally investigate for changes in CD4+ T cells, T-regulatory cells (Tregs), and T-helper-1 cells (TH1s) in association with the presence of VCAN and Vkine. Methods: VCAN, Vkine, TIL, and T cell abundance were

APA, Harvard, Vancouver, ISO, and other styles

9

Kraus, Sean G., Kristina A. Matkowskyj, Philip B. Emmerich, et al. "Abstract 3842: Versican proteolysis is a predictive biomarker of tumor infiltrating lymphocytes within primary and metastatic colorectal cancer tumors." Cancer Research 82, no. 12_Supplement (2022): 3842. http://dx.doi.org/10.1158/1538-7445.am2022-3842.

Full text

Abstract:

Abstract Background: A major roadblock to immune-therapy response in many solid malignancies is the lack of tumor-infiltrating lymphocytes (TILs) found within their immune micro-environments. These immunologically cold tumors have lower response rates to immune-based therapies and among all colorectal cancers (CRC), only about six percent of patients have an objective response to immune checkpoint blockade (ICB). Versican (VCAN) accumulation has been found to be negatively correlated with TILs and its proteolysis into versikine (Vkine) correlates with higher TILs. In this study we analyze the

APA, Harvard, Vancouver, ISO, and other styles

10

Asimakopoulos, Fotis, Chelsea Hope, Philip Emmerich, et al. "Versican proteolysis is associated with robust CD8+ T-cell infiltration in human mismatch repair-proficient and -deficient colorectal cancers." Journal of Immunology 198, no. 1_Supplement (2017): 76.28. http://dx.doi.org/10.4049/jimmunol.198.supp.76.28.

Full text

Abstract:

Abstract Colorectal cancer (CRC) originates within immunologically complex microenvironments. To date the benefits of immunotherapy have been modest except in neoantigen-laden mismatch repair (MMR)-deficient tumors. Approaches to enhance tumor-infiltrating lymphocytes in the tumor bed may substantially augment clinical immunotherapy responses. We recently reported that proteolysis of the tolerogenic matrix proteoglycan versican (VCAN), in myeloma tumors, generates a bioactive fragment, versikine, with putative immunostimulatory activities. We show that VCAN proteolysis strongly correlated with

APA, Harvard, Vancouver, ISO, and other styles

11

Deming, Dustin A., Chelsea Hope, Philip Emmerich, et al. "Versican proteolysis as a key regulator of CD8+ T-cell infiltration in colorectal cancer." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15082-e15082. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15082.

Full text

Abstract:

e15082 Background: Colorectal cancer (CRC) originates within immunologically complex microenvironments. To date the benefits of immunotherapy have been modest except in neoantigen-laden mismatch repair (MMR)-deficient tumors. Approaches to enhance tumor-infiltrating lymphocytes (TILS) in the tumor bed may substantially augment clinical immunotherapy responses. Proteolysis of the tolerogenic matrix proteoglycan versican (VCAN) generates a bioactive fragment, versikine, with putative immunostimulatory activities. Methods: Matched normal and CRC tissue samples were collected from 122 patients wit

APA, Harvard, Vancouver, ISO, and other styles

12

Luo, Hao-Lun, Yin-Lun Chang, Hui-Ying Liu, et al. "VCAN Hypomethylation and Expression as Predictive Biomarkers of Drug Sensitivity in Upper Urinary Tract Urothelial Carcinoma." International Journal of Molecular Sciences 24, no. 8 (2023): 7486. http://dx.doi.org/10.3390/ijms24087486.

Full text

Abstract:

Versican (VCAN), also known as extracellular matrix proteoglycan 2, has been suggested as a potential biomarker in cancers. Previous research has found that VCAN is highly expressed in bladder cancer. However, its role in predicting outcomes for patients with upper urinary tract urothelial cancer (UTUC) is not well understood. In this study, we collected tissues from 10 patients with UTUC, including 6 with and 4 without lymphovascular invasion (LVI), a pathological feature that plays a significant role in determining metastasis. Results from RNA sequencing revealed that the most differentially

APA, Harvard, Vancouver, ISO, and other styles

13

Kraus, Sean, Philip Emmerich, Mitch Hayes, et al. "Abstract 99: Versican regulates T cell abundance within the colorectal cancer microenvironment." Cancer Research 84, no. 6_Supplement (2024): 99. http://dx.doi.org/10.1158/1538-7445.am2024-99.

Full text

Abstract:

Abstract Background: Clinical benefit from immunotherapy is seen in a minority of patients with metastatic colorectal cancer (CRC). Identifying how the tumor microenvironment (TME) influences immune infiltration and treatment response is an unmet need. Versican (VCAN), a chondroitin sulfate proteoglycan, common in the CRC TME has immunoregulatory properties and can be cleaved releasing an immunostimulatory product, versikine (Vkine). Here we evaluate the impact of the abundance of VCAN and Vkine on CD8+ T cell infiltration in CRC. Methods: Samples include 306 primary colon tumors, an additiona

APA, Harvard, Vancouver, ISO, and other styles

14

Field, Anna, Sean Kraus, Kristina Matkowskyj, Dustin Deming, Cheri A. Pasch, and Wei Zhang. "Abstract 4647: Potential of TIMP3 regulating the versican status in the colorectal cancer tumor microenvironment." Cancer Research 83, no. 7_Supplement (2023): 4647. http://dx.doi.org/10.1158/1538-7445.am2023-4647.

Full text

Abstract:

Abstract Background: In colorectal cancer (CRC), versican (VCAN) accumulation has been found to negatively correlate with CD8+ tumor infiltrating lymphocyte (TIL) abundance and its proteolysis into versikine (Vkine) positively correlates with TIL abundance. TIMP3 has demonstrated the ability to inhibit several ADAMTS proteases able to cleave VCAN to Vkine. Here we investigate the correlation of TIMP3 accumulation in CRCs with the VCAN status and CD8+ T cell infiltration. Methods: Matched primary and metastatic CRC samples from 156 patients who had resected oligometastatic CRC were stained for

APA, Harvard, Vancouver, ISO, and other styles

15

WADA, Tomotaka, Yuki NAKANISHI, Ryohta YAMAGUCHI, Kazushi FUJIMOTO, and Hiromi OKADA. "Pedestrian Oriented Vehicular Collision Avoidance Support System: P-VCASS." IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences E93-A, no. 4 (2010): 679–88. http://dx.doi.org/10.1587/transfun.e93.a.679.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Short, Kelly L., A. Daniel Bird, Bennet K. L. Seow, et al. "Glucocorticoid signalling drives reduced versican levels in the fetal mouse lung." Journal of Molecular Endocrinology 64, no. 3 (2020): 155–64. http://dx.doi.org/10.1530/jme-19-0235.

Full text

Abstract:

Glucocorticoid (GC) signaling via the glucocorticoid receptor (GR) is essential for lung maturation in mammals. Previous studies using global or conditional mouse model knockouts of the GR gene have established that GR-mediated signaling in the interstitial mesenchyme of the fetal lung is critical for normal lung development. Screens for downstream GC-targets in conditional mesenchymal GR deficient mouse lung (GRmesKO) identified Versican (Vcan), an important extracellular matrix component and cell proliferation regulator, as a potential GR-regulated target. We show that, of the five major VCA

APA, Harvard, Vancouver, ISO, and other styles

17

Dhakal, Binod, Muhammad Umair Mushtaq, Ashley Cunningham, et al. "Versican (VCAN) Proteolysis Predicts Survival in Multiple Myeloma (MM) after High Dose Therapy and Autologous Hematopoietic Cell Transplantation (HDT/AHCT)." Blood 134, Supplement_1 (2019): 3088. http://dx.doi.org/10.1182/blood-2019-127565.

Full text

Abstract:

Background: Despite unprecedented response rates associated with "novel agents", HDT/AHCT is a therapeutic mainstay for transplant eligible patients with MM. However, relapse is universal and almost all patients diagnosed with symptomatic myeloma will die of their disease. The immunosuppressive network orchestrated by regulatory myeloid or lymphoid cells and effector dysfunction characterize relapses in MM. We have shown that myeloma-infiltrating myeloid cells produce versican (VCAN), a large matrix proteoglycan that promotes tumor sustaining inflammation and immunosuppression. VCAN proteolysi

APA, Harvard, Vancouver, ISO, and other styles

18

Zhu, Jiang, Guangjie Duan, Lang Lang, et al. "The Bacterial Component Flagellin Induces Anti-Sepsis Protection Through TLR-5, IL-1RN and VCAN During Polymicrobial Sepsis in Mice." Cellular Physiology and Biochemistry 36, no. 2 (2015): 446–56. http://dx.doi.org/10.1159/000430111.

Full text

Abstract:

Background: The present study was designed to observe the effects of the bacterial component flagellin on anti-sepsis protection through TLR-5, VCAN and IL-1RN. Methods: A clinically relevant model of sepsis was induced by cecal ligation and puncture (CLP). An in vitro culture of endothelial cells was analyzed. Results: Flagellin induced anti-sepsis protection through inhibition of inflammation and induction of endothelial proliferation by down-regulating the expression of TLR 3, TLR 4, and IL-1RN and promoting the expression of VCAN in mice 24 h post-CLP. In vitro, flagellin promoted the prol

APA, Harvard, Vancouver, ISO, and other styles

19

Li, Songshan, Mengke Li, Limei Sun, et al. "Identification of Novel Copy Number Variations of VCAN Gene in Three Chinese Families with Wagner Disease." Genes 11, no. 9 (2020): 992. http://dx.doi.org/10.3390/genes11090992.

Full text

Abstract:

The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican). Heterozygous variants targeting exon 8 of VCAN have been shown to cause Wagner disease, a rare autosomal dominant non-syndromic vitreoretinopathy that induces retinal detachment, cataracts and permanent visual loss. In this study, we report on six patients from three unrelated families with Wagner disease in whom we identified three novel copy number variations of VCAN. Quantitative real-time polymerase chain reaction analysis identified deletions, includi

APA, Harvard, Vancouver, ISO, and other styles

20

Field, Elizabeth L., Sean Kraus, Madeleine Buratti, et al. "Abstract 3282: Versican abundance/proteolysis as a biomarker for immunotherapy efficacy in intestinal cancers." Cancer Research 85, no. 8_Supplement_1 (2025): 3282. https://doi.org/10.1158/1538-7445.am2025-3282.

Full text

Abstract:

Abstract Background: The composition of the tumor microenvironment (TME) can regulate T cell infiltration and potentially immunotherapy efficacy. Versican (VCAN), an extracellular matrix proteoglycan, regulates the presence of tumor infiltrating lymphocytes (TILs) and their activation, while its proteolytic byproduct, versikine (Vkine), can stimulate an immune response. Here we aim to validate our prior findings that VCAN status correlates with CD8+ T cell infiltration in intestinal cancers and evaluate the predictive role of VCAN/Vkine for patients undergoing immunotherapy for microsatellite

APA, Harvard, Vancouver, ISO, and other styles

21

Kulathumani, V., R. A. Moparthi, and Y. P. Fallah. "VCAST: Scalable Dissemination of Vehicular Information with Distance-Sensitive Precision." International Journal of Distributed Sensor Networks 9, no. 11 (2013): 586193. http://dx.doi.org/10.1155/2013/586193.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Tang, Yongyu, Ying Chen, Qianqian Guo, et al. "MiR-126-Loaded Immunoliposomes against Vascular Endothelial Inflammation In Vitro and Vivo Evaluation." Pharmaceutics 15, no. 5 (2023): 1379. http://dx.doi.org/10.3390/pharmaceutics15051379.

Full text

Abstract:

Due to the accompaniment of vascular endothelial inflammation during the occurrence and development of cardiovascular diseases (CVD), treatment modalities against vascular endothelial inflammation have been intensively investigated for CVD prevention and/or treatment. Vascular cell adhesion molecule-1 (VCAM-1) is a typical transmembrane inflammatory protein specifically expressed by inflammatory vascular endothelial. By inhibiting VCAM-1 expression through the miR-126 mediated pathway, vascular endothelial inflammation can be efficiently relieved. Inspired by this, we developed a miR-126-loade

APA, Harvard, Vancouver, ISO, and other styles

23

Bérubé, Caterina, Theresa Schachner, Roman Keller, et al. "Voice-Based Conversational Agents for the Prevention and Management of Chronic and Mental Health Conditions: Systematic Literature Review." Journal of Medical Internet Research 23, no. 3 (2021): e25933. http://dx.doi.org/10.2196/25933.

Full text

Abstract:

Background Chronic and mental health conditions are increasingly prevalent worldwide. As devices in our everyday lives offer more and more voice-based self-service, voice-based conversational agents (VCAs) have the potential to support the prevention and management of these conditions in a scalable manner. However, evidence on VCAs dedicated to the prevention and management of chronic and mental health conditions is unclear. Objective This study provides a better understanding of the current methods used in the evaluation of health interventions for the prevention and management of chronic and

APA, Harvard, Vancouver, ISO, and other styles

24

Gauthier, Valentine, Elly Tyler, Ying Liu, Tyson V. Sharp, and Oliver MT Pearce. "Abstract 1339: Targeting specific extracellular matrix proteins to reactivate T cell trafficking in triple-negative breast cancer." Cancer Research 83, no. 7_Supplement (2023): 1339. http://dx.doi.org/10.1158/1538-7445.am2023-1339.

Full text

Abstract:

Abstract It is now widely recognised that the tumour microenvironment (TME) is playing a crucial role in promoting tumour immune evasion by modulating the local immune infiltration. A growing body of evidence highlights the crucial role of the tumour extracellular matrix (ECM) in limiting trafficking of newly activated T cells in solid cancers, thus restricting their access to tumour and preventing the success of cancer immunotherapies. Accordingly, we are investigating whether targeting specific tumour ECM components may enhance T cell infiltration in triple-negative breast cancer (TNBC). Mat

APA, Harvard, Vancouver, ISO, and other styles

25

Guo, Jia, and Yuan Liu. "INHBA promotes the proliferation, migration and invasion of colon cancer cells through the upregulation of VCAN." Journal of International Medical Research 49, no. 6 (2021): 030006052110149. http://dx.doi.org/10.1177/03000605211014998.

Full text

Abstract:

Objective Colon cancer has high morbidity and mortality rates, and proliferation, invasion and migration play an important role in colon cancer progression. Here, the effects of inhibin subunit beta A (INHBA) on cell proliferation, invasion and migration were investigated. Methods The UALCAN database was used to assess INHBA expression in colon cancer tissues and predict the survival of patients with high and low INHBA expression. The relevant proteins were detected by RT-qPCR and western blot. Cell transfection was performed to overexpress or inhibit INHBA and versican (VCAN). The high correl

APA, Harvard, Vancouver, ISO, and other styles

26

Reboita, Michelle Simões, and José Augusto Paixão Veiga. "Análise Sinótica e Energética de um VCAN que Causou Chuva no Deserto do Atacama em Março de 2015." Revista Brasileira de Meteorologia 32, no. 1 (2017): 123–39. http://dx.doi.org/10.1590/0102-778632120160019.

Full text

Abstract:

Resumo Os Vórtices Ciclônicos de Altos Níveis (VCANs) subtropicais são sistemas de baixa pressão em médios e altos níveis da atmosfera, com centro frio e que se encontram segregados para o lado equatorial das correntes de jato. A divergência de massa no setor a jusante dos VCANs pode organizar os movimentos ascendentes na atmosfera e precipitação. Diante da contribuição dos VCANs para alterações no tempo e os poucos estudos desses sistemas na literatura, o presente trabalho descreve a evolução sinótica e energética de um VCAN que causou evento extremo chuvoso no deserto do Atacama, entre os di

APA, Harvard, Vancouver, ISO, and other styles

27

Wada-Katsumata, Ayako, Ludek Zurek, Godfrey Nalyanya, Wendell L. Roelofs, Aijun Zhang, and Coby Schal. "Gut bacteria mediate aggregation in the German cockroach." Proceedings of the National Academy of Sciences 112, no. 51 (2015): 15678–83. http://dx.doi.org/10.1073/pnas.1504031112.

Full text

Abstract:

Aggregation of the German cockroach, Blattella germanica, is regulated by fecal aggregation agents (pheromones), including volatile carboxylic acids (VCAs). We demonstrate that the gut microbial community contributes to production of these semiochemicals. Chemical analysis of the fecal extract of B. germanica revealed 40 VCAs. Feces from axenic cockroaches (no microorganisms in the alimentary tract) lacked 12 major fecal VCAs, and 24 of the remaining compounds were represented at extremely low amounts. Olfactory and aggregation bioassays demonstrated that nymphs strongly preferred the extract

APA, Harvard, Vancouver, ISO, and other styles

28

Deming, Dustin A., Sam Joseph Lubner, Nataliya Volodymyrivna Uboha, et al. "Phase Ib of pembrolizumab (pem) in combination with stereotactic body radiotherapy (SBRT) for resectable liver oligometastatic MMR-proficient (pMMR) colorectal cancer (CRC): Final results." Journal of Clinical Oncology 41, no. 4_suppl (2023): 161. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.161.

Full text

Abstract:

161 Background: SBRT is a standard treatment option for oligometastatic CRC and is associated with an increase in immunogenic antigen release and influx of immune cells. We hypothesized that radiation would enhance the immunogenicity of pMMR CRC and potentiate the effectiveness of PD-1 blockade. This phase Ib study examined the safety and efficacy of the sequential combination of SBRT and Pem in patients (pts) undergoing resection of their disease. Additionally, the accumulation and proteolysis of versican (VCAN), an immunoregulatory tumor matrix proteoglycan was examined as a novel immunother

APA, Harvard, Vancouver, ISO, and other styles

29

Wada, Tomotaka, and Ruka Ohtani. "Performance of P-VCASS using a warning area based on pedestrian behavior." IEICE Communications Express 10, no. 7 (2021): 386–90. http://dx.doi.org/10.1587/comex.2021xbl0058.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Shah, Ruchi, Sean G. Kraus, Somak Chaudhuri, et al. "Abstract 1607: Versican status in the tumor microenvironment heterogeneously impacts immune infiltration and inflammatory pathway expression." Cancer Research 85, no. 8_Supplement_1 (2025): 1607. https://doi.org/10.1158/1538-7445.am2025-1607.

Full text

Abstract:

Background: Versican (VCAN) and its proteolysis product, Versikine (Vkine), have been shown to regulate CD8+ T-cell infiltration in cancers. Here, we evaluate the impact of VCAN proteolysis and accumulation on immune infiltration and immune-related pathway expression across cancer types. Methods: RNA expression (Z-score) signatures of VCANhi/ADAMTS4hi/TIMP3lo and VCANhi/ADAMTS4lo/TIMP3hi were used to identify VCAN proteolytic predominant (VPP) and weak (VPW) cohorts, respectively, from TCGA Pan-cancer Atlas datasets. Gene-set enrichment analysis was performed between VPP and VPW cohorts for ea

APA, Harvard, Vancouver, ISO, and other styles

31

Sureau, Solène, François Lohest, Joris Van Mol, Tom Bauler, and Wouter M. J. Achten. "How Do Chain Governance and Fair Trade Matter? A S-LCA Methodological Proposal Applied to Food Products from Belgian Alternative Chains (Part 2)." Resources 8, no. 3 (2019): 145. http://dx.doi.org/10.3390/resources8030145.

Full text

Abstract:

Alternative food networks (AFNs) have emerged to improve both environmental and socio-economic aspects of food provisioning, including the living and working conditions of farmers. Their objectives are supposed to be mediated through the shortening of chains and/or the implication of alternative value chain actors (VCAs). Through the application of a social life cycle assessment methodological proposal on two products from three Belgian AFNs, we first verify how the AFNs meet sustainability promises. Second, we investigate how such social sustainability of the assessed products is influenced b

APA, Harvard, Vancouver, ISO, and other styles

32

Souza, Maria Carolina, Simone Nunes, Samantha Hellen Santos Figuerêdo, et al. "Versican Proteolysis by ADAMTS: Understanding Versikine Expression in Canine Spontaneous Mammary Carcinomas." Cancers 16, no. 23 (2024): 4057. https://doi.org/10.3390/cancers16234057.

Full text

Abstract:

Background: The present study investigates VKINE, a bioactive proteolytic fragment of the proteoglycan VCAN, as a novel and significant element in the tumor extracellular matrix (ECM). Although VKINE has been recognized for its immunomodulatory potential in certain tumor types, its impact on ECM degradation and prognostic implications remains poorly understood. Objectives: This study aimed to evaluate VCAN proteolysis and its association with ADAMTS enzymes involved in extracellular matrix remodeling in spontaneous canine mammary gland cancer. Methods: The expression levels of VKINE, ADAMTS en

APA, Harvard, Vancouver, ISO, and other styles

33

Chaudhuri, Somak, Yousef Gadalla, Katherine A. Johnson, et al. "Abstract 5116: Alpha-2-macroglobulin in the tumor microenvironment of pancreatic ductal adenocarcinoma to regulate versican proteolysis." Cancer Research 85, no. 8_Supplement_1 (2025): 5116. https://doi.org/10.1158/1538-7445.am2025-5116.

Full text

Abstract:

Abstract Background: Versican (VCAN), a large chondroitin sulfate matrix proteoglycan is upregulated in the pancreatic ductal adenocarcinoma (PDAC) stroma and plays an immunosuppressive role. In contrast, the VCAN V1 isoform can be cleaved by ADAMTS proteases 1, 4, 5, 9, 15 and 20 into the fragment versikine which is known to be immunostimulatory. PDAC displays poor VCAN proteolysis and CD8+ T-cell infiltration, but interestingly overexpresses ADAMTS 1, 4, 5 and 9. Alpha-2-macroglobulin (A2M) has been shown to inhibit ADAMTS 4 and 5 and may be overexpressed in the PDAC tumor microenvironment (

APA, Harvard, Vancouver, ISO, and other styles

34

Hamilton, A. "Vegetation, Climate and Soil: Altitudinal Relationships on the East Usambara Mountains, Tanzania." Journal of East African Natural History 87, no. 1 (1998): 85–89. http://dx.doi.org/10.2982/0012-8317(1998)87[85:vcasar]2.0.co;2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Peterson, Joshua, Pablo Padilla, Kelsey Gray, et al. "109 Vascular Composite Allotransplantation in Burn Reconstruction: Systematic Review and Meta-analysis." Journal of Burn Care & Research 41, Supplement_1 (2020): S72—S73. http://dx.doi.org/10.1093/jbcr/iraa024.112.

Full text

Abstract:

Abstract Introduction The first vascular composite allotransplantation (VCA) was performed in 1998, with the first post-burn VCA in 2003. Since then, 21 burn patients have been recipients of VCAs. Controversy exists regarding safety of VCA in burn patients due to high levels of immunologic sensitization attributed to use of cadaver allograft. We seek to understand unique considerations of VCA in burn reconstruction and its relative safety compared to VCA in non-burn reconstruction. Methods A systematic review of VCA in burn reconstruction was conducted using the PubMed, Media and EBSCO databas

APA, Harvard, Vancouver, ISO, and other styles

36

Brunn, David, Kati Turkowski, Stefan Günther, et al. "Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican." Cancers 13, no. 2 (2021): 208. http://dx.doi.org/10.3390/cancers13020208.

Full text

Abstract:

Transcription factors can serve as links between tumor microenvironment signaling and oncogenesis. Interferon regulatory factor 9 (IRF9) is recruited and expressed upon interferon stimulation and is dependent on cofactors that exert in tumor-suppressing or oncogenic functions via the JAK-STAT pathway. IRF9 is frequently overexpressed in human lung cancer and is associated with decreased patient survival; however, the underlying mechanisms remain to be elucidated. Here, we used stably transduced lung adenocarcinoma cell lines (A549 and A427) to overexpress or knockdown IRF9. Overexpression led

APA, Harvard, Vancouver, ISO, and other styles

37

Brunn, David, Kati Turkowski, Stefan Günther, et al. "Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican." Cancers 13, no. 2 (2021): 208. http://dx.doi.org/10.3390/cancers13020208.

Full text

Abstract:

Transcription factors can serve as links between tumor microenvironment signaling and oncogenesis. Interferon regulatory factor 9 (IRF9) is recruited and expressed upon interferon stimulation and is dependent on cofactors that exert in tumor-suppressing or oncogenic functions via the JAK-STAT pathway. IRF9 is frequently overexpressed in human lung cancer and is associated with decreased patient survival; however, the underlying mechanisms remain to be elucidated. Here, we used stably transduced lung adenocarcinoma cell lines (A549 and A427) to overexpress or knockdown IRF9. Overexpression led

APA, Harvard, Vancouver, ISO, and other styles

38

Chen, Robert, and Wei-hsuan Yu. "Matrix Proteins and Proteinases Network in Human Cardiovascular Diseases Explored By Cytoscape." Research Ideas and Outcomes 2 (June 27, 2016): e9617. https://doi.org/10.3897/rio.2.e9617.

Full text

Abstract:

Matrix proteins and proteinases altered extracellular matrix that involves in various pathogenesis of cardiovascular diseases. Systematic review selected matrix metalloproteinase-7 (MMP7), a disintegrin and metalloproteinase-17 (ADAM17), type I collagen (COL1), syndecan (SDC), and versican (VCAN). Their network was drawn by Cytoscape and Agilent Literature Search. MMP7, ADAM17, and SDC were grouped together. VCAN and COL1 had inadequate evidence to connect their human potential networks that were more evidence in animal models. The findings may provide clues for further laboratory investigatio

APA, Harvard, Vancouver, ISO, and other styles

39

Timms, Katherine Payne, and Sean Bertram Maurice. "Context-dependent bioactivity of versican fragments." Glycobiology 30, no. 6 (2019): 365–73. http://dx.doi.org/10.1093/glycob/cwz090.

Full text

Abstract:

Abstract Versican (VCAN) proteolysis and the accumulation of VCAN fragments occur in many developmental and disease processes, affecting extracellular matrix (ECM) structure and cell phenotype. Little is known about the significance of proteolysis and the roles of fragments, or how this ECM remodeling affects the microenvironment and phenotype of diseased cells. G1-DPEAAE fragments promote aspects of epithelial–mesenchymal transitioning in developing and diseased cells, resulting in cell migration. Enhanced proliferation and invasion of tumor and endothelial cells is directly associated with G

APA, Harvard, Vancouver, ISO, and other styles

40

Pendexter, Casie A., Omar Haque, Mohammadreza Mojoudi, et al. "Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol." PLOS ONE 18, no. 1 (2023): e0266207. http://dx.doi.org/10.1371/journal.pone.0266207.

Full text

Abstract:

Vascularized composite allografts (VCAs) refer to en bloc heterogenous tissue that is transplanted to restore form and function after amputation or tissue loss. Rat limb VCA has emerged as a robust translational model to study the pathophysiology of these transplants. However, these models have predominately focused on hindlimb VCAs which does not translate anatomically to upper extremity transplantation, whereas the majority of clinical VCAs are upper extremity and hand transplants. This work details our optimization of rat forelimb VCA procurement and sub-normothermic machine perfusion (SNMP

APA, Harvard, Vancouver, ISO, and other styles

41

UEKI, J. "Vehicular-Collision Avoidance Support System (VCASS) by Inter-Vehicle Communications for Advanced ITS." IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences E88-A, no. 7 (2005): 1816–23. http://dx.doi.org/10.1093/ietfec/e88-a.7.1816.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Yang, Jerry Huanda, Ariel C. Johnson, Salih Colakoglu, Christene A. Huang, and David Woodbridge Mathes. "Clinical and preclinical tolerance protocols for vascularized composite allograft transplantation." Archives of Plastic Surgery 48, no. 6 (2021): 703–13. http://dx.doi.org/10.5999/aps.2021.00927.

Full text

Abstract:

The field of vascularized composite allografts (VCAs) has undergone significant advancement in recent decades, and VCAs are increasingly common and accepted in the clinical setting, bringing hope of functional recovery to patients with debilitating injuries. A major obstacle facing the widespread application of VCAs is the side effect profile associated with the current immunosuppressive regimen, which can cause a wide array of complications such as infection, malignancy, and even death. Significant concerns remain regarding whether the treatment outweighs the risk. The potential solution to t

APA, Harvard, Vancouver, ISO, and other styles

43

Dupuis, Loren E., Sarah E. Evins, Morgan C. Abell, et al. "Increased Proteoglycanases in Pulmonary Valves after Birth Correlate with Extracellular Matrix Maturation and Valve Sculpting." Journal of Cardiovascular Development and Disease 10, no. 1 (2023): 27. http://dx.doi.org/10.3390/jcdd10010027.

Full text

Abstract:

Increased mechanical forces on developing cardiac valves drive formation of the highly organized extracellular matrix (ECM) providing tissue integrity and promoting cell behavior and signaling. However, the ability to investigate the response of cardiac valve cells to increased mechanical forces is challenging and remains poorly understood. The developmental window from birth (P0) to postnatal day 7 (P7) when biomechanical forces on the pulmonary valve (PV) are altered due to the initiation of blood flow to the lungs was evaluated in this study. Grossly enlarged PV, in mice deficient in the pr

APA, Harvard, Vancouver, ISO, and other styles

44

Lopes, Raquel, Ana C. Queirós, Diana Lourenço, et al. "Characterizing the Multiple Myeloma Bone Marrow Microenvironment at the Single-Cell Level in a Preclinical Model." Blood 144, Supplement 1 (2024): 4664. https://doi.org/10.1182/blood-2024-205433.

Full text

Abstract:

Introduction: Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of plasma cells within the bone marrow (BM), facilitated by a supportive microenvironment that promotes tumor growth and survival. The immune dysregulation spans both myeloid and lymphoid compartments, further complicating treatment. Immunotherapy, which aims to stimulate the immune system to attack tumor cells, has shown promising results but MM remains incurable due to persistent disease relapse. A deeper understanding of the immune cells' heterogeneity at the cellular level and their dynamic

APA, Harvard, Vancouver, ISO, and other styles

45

Papadas, Athanasios, Gauri Deb, Adam Officer, et al. "936 Stromal remodeling regulates dendritic cell abundance in the tumor microenvironment." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A982. http://dx.doi.org/10.1136/jitc-2021-sitc2021.936.

Full text

Abstract:

BackgroundStimulatory dendritic cells (SDC), enriched within the Batf3-DC lineage (also known as conventional type 1 DC, cDC1), engage in productive interactions with CD8+ effectors along tumor-stroma boundaries. This puzzling pattern of T-cell-DC localization has been interpreted as ”tumor-exclusion”, limiting anti-tumor immunity. To understand this paradox, we hypothesized that dynamic matrix remodeling at the invasive margin generates unique activation and cell-fate cues critical for Batf3-DC homeostasis.MethodsWe studied immunocompetent tumor models of lung carcinoma, breast carcinoma, mel

APA, Harvard, Vancouver, ISO, and other styles

46

Buckalew, Derek, Sean Kraus, Katie Johnson, Cheri A. Pasch, and Dustin A. Deming. "Abstract 69: Versican proteolysis signature as a potential immune infiltration biomarker for colorectal cancer." Cancer Research 84, no. 6_Supplement (2024): 69. http://dx.doi.org/10.1158/1538-7445.am2024-69.

Full text

Abstract:

Abstract Background: A subset of patients with mismatch repair proficient colorectal cancers (CRCs) benefit from immunotherapies, though currently no markers predict which cancers are likely to respond. Our group demonstrated that versican (VCAN), an immunoregulatory tumor matrix proteoglycan, when proteolyzed to an immunostimulatory fragment called versikine (Vkine) results in enhanced CD8+ T cell infiltration across multiple cancers. Here we evaluate if a RNA expression signature of VCAN proteolysis can identify CRCs with an immune cell infiltrated phenotype. Methods: The TCGA PanCancer Atla

APA, Harvard, Vancouver, ISO, and other styles

47

Cordeiro, Edwans Silva, Natalia Fedorova, and Vladimir Levit. "Análise sinótica e Termodinâmica dos Eventos com Trovoadas para o Estado de Alagoas no Período de 15 Anos 1998-2012." Revista Brasileira de Meteorologia 33, no. 4 (2018): 685–94. http://dx.doi.org/10.1590/0102-77863340010.

Full text

Abstract:

Resumo Alagoas é afetado pelas trovoadas e buscando mitigar tais transtornos, este trabalho propõe-se a compreender melhor os sistemas sinóticos associados às mesmas. Dados do Departamento do Controle do Espaço Aéreo (DECEA) e do satélite Tropical Rainfall Measuring Mission (TRMM) foram utilizados para estimar a frequência das trovoadas. Também foram aplicados dados de reanálise do National Centers for Environmental Prediction (NCEP). Foram encontrados no Estado cerca de 212 eventos com trovoadas em 15 anos. A maior ocorrência foi observada em 2008 (21 casos) e a menor ocorrência em 2012 (04 c

APA, Harvard, Vancouver, ISO, and other styles

48

Chi, Hengxuan, and Karl R. Englund. "Interfacial properties of magnesium phosphate ceramics and sugar maple (Acer saccharum)." Holzforschung 68, no. 5 (2014): 575–82. http://dx.doi.org/10.1515/hf-2013-0113.

Full text

Abstract:

Abstract The interfacial shear strength (τi) between magnesium phosphate ceramics (MPC) and sugar maple (Acer saccharum) has been evaluated by means of a pullout test method. The binder system monopotassium phosphate (MKP) and magnesium oxide (MgO) resulted in the highest τi at a MKP/MgO ratio of 3:1. The influence of the levels of MPC binder and aggregates on the interfacial properties has been observed based on a mixture design model. The aggregates were Portland cement (PC), wollastonite (WO), and vitrified calcium aluminosilicates (VCAS). The MPC binder level was the primary factor influen

APA, Harvard, Vancouver, ISO, and other styles

49

Huang, Wei-Chao, Jeng-Yee Lin, Christopher Glenn Wallace, Fu-Chan Wei, and Shuen-Kuei Liao. "Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts." Clinical and Developmental Immunology 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/107901.

Full text

Abstract:

Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve

APA, Harvard, Vancouver, ISO, and other styles

50

Chang, Mary Y., Inkyung Kang, Michael Gale, et al. "Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs." American Journal of Physiology-Lung Cellular and Molecular Physiology 313, no. 6 (2017): L1069—L1086. http://dx.doi.org/10.1152/ajplung.00353.2017.

Full text

Abstract:

Growing evidence suggests that versican is important in the innate immune response to lung infection. Our goal was to understand the regulation of macrophage-derived versican and the role it plays in innate immunity. We first defined the signaling events that regulate versican expression, using bone marrow-derived macrophages (BMDMs) from mice lacking specific Toll-like receptors (TLRs), TLR adaptor molecules, or the type I interferon receptor (IFNAR1). We show that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!